Gene MTMR1-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP023_AA protein Get Run
AqueP023_AA_876-1265 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR1_pd Subfamily MTMR1 880-1261 1.5e-144 474.0 In-house 8-387 (389) alignment 
Range on Protein: 880-1261
Range on HMM: 8-387/389.0
NFFHFNAEMERTGILNAKigntsLWRITTITKTNpDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSerGLQSSKLP
......||.||.|.||.|     |||||...|.. .||..||..|||.....| || . ......||.|...|.||.|..|.|||.....  ||.... .
kvydpeaelerlgllnek.....lWritklnkky.elcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplv..Glsgkrsk

VDEAILQAIRGCNANS-RLFVFTEKSDTSGFQDPNKlTKEAARSYYYHNCHFIYsVNPPTYKSVRHSFNKLQAMLQSNISDDEYMVTLDGTKWLSRVGDL
 ||..||||. .||.| .|......|....... .| .|.......|.|...|. ........||.|..||......|..|......|..||||... ..
edekylqaileanaqsekllildarssvnavankak.gkgyeseeaYknaelif.ldihnihvvReslkklkelvlpnvddkkwlsalestkWlehikli

LDTAHKVVEALTVESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRsraavGGASSKIKEDGPVFLQWIDCVWQI
|..|.|.||....|...|||....|||||.|..|||.||.|.||||..||.|||.||||.|||.|..|...     |...|...|..|||||.||||||.
lagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlgh.....gdknssdaersPvFlqfiDcvwql

TRQCPFAFEFNENLLICFMipDHYHQ-----------------SIYTNTISFWTWvsmVNSSNNIFFNNYYDPDFHKGAIYPKFYQTCLEIWRTHYDRHK
|||.|.||||||..||...  ||...                 .....|.|.|..   ||||.. |.|..|.....| ..|||.....||.|...| |..
trqfptAFefneefLitll..dhlysclfGtflfnsekervkekvkektvslwsy...vnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwn
Myotub-related Myotubularin-like phosphatase domain 880-1207 8.4e-81 264.4 Pfam-A 22-339 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 880-1207 8.4e-81 264.4 In-house 22-339 (353) alignment
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 880-1232 4.5e-70 228.8 In-house 17-367 (404) alignment 
Range on Protein: 880-1232
Range on HMM: 17-367/404.0
NFFHFNAEMERTGILNAKigntsLWRITTITkTNPDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTseRGLQSSKLP
.... . | .| || .        |||..|  .. .||..||. |||   | | .| .     ..||.|. .| ..|..|.. |..  .   ||. |.  
liydaeeEykRlgikses.....eWriskin.sdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqpl..vGltksrse

VDEAILQAIRG-CNANSRLFVFTEKSDTSGFQDPNKLTKEAARSYyYHNCHfIYSVNPPTYKSVRHSFNKLQAMLQSNISD-DEYMVTLDGTKWLSRVGD
 || ....||  ... . |..   .. ..  .  .| ..    |  |.||. | . |    ...|.|..||. . .|.|.. ....  |. ..|| ..  
edEklinsirkaktqletlyildarpkanavansakgagyedisr.yence.ieflnienihelreslkklkkavnsiiekeknwlselessrWldhikl

LLDTAHKVVEALTVESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRsraavgGASSKIKEDGPVFLQWIDCVWQ
|| .....|| .  |.  |||    |||||.|..||.||| ||||||. ||.|||.|||| ||| |..|...        . . .|  |.|||.||||.|
llegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq......ttekssdersPiflqFidcvyq

ITRQCPFAFEFNENLLICFM------------IPDHYHQ---SIYTNTISFWTwvsMVNSSNNIFFNNYY
.|.| |  |||||..||  .               . .     ....|.|.|.   .... .. ..|..|
ltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWa...lleankseylnply
subfamily_MTMR6_pd Subfamily MTMR6 880-1260 4.3e-60 196.1 In-house 20-395 (397) alignment 
Range on Protein: 880-1260
Range on HMM: 20-395/397.0
NFFHFNAEMERTGILNAKigntslWRITTITKtNPDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSerGLQSsKLP
. .. .||..| |. |.|      | .| . | . .|| .||..|.|   .    |.   .    ||.|  ... |.| . . |..   |  |... .  
klldlkaeytrmgvpnek......wtltdlnk.dyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqpls..gfsa.rcl

VDEAILQAIRGCNANSRL-FVFTEKSDTSGFQDpNKLTKEAARSYYYHNCHFIYsVNPPTYKSVRHSFNKLQAML-QSNISDDEYMVTLDGTKWLSRVGD
 ||..|.||| .|.||.| .|   .     . . .   |       |.|..| . |.    . .|.| .||  .  ... |  |.. .|. ..||  .  
edeklleairkanpnsellyvvdtrpklnalan.kaagkGyenednysnikfqf.vgienihvmreslqkllevvelksksvseflsglessgwlkhika

LLDTAHKVVEALTVESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRSraavggaSSKIKEDGPVFLQWIDCVWQ
.||..  . .|.. | | |||    |||||.|..|||.|| ||||||..||.|||.|||| ||| |..|           ... ||  |.|.|...||||
vldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll.......dedskevsPiftqflecvwq

ITRQCPFAFEFNENLLICF------------M---IPDHYHQSIYTNTISFWTWVSmvnSSNNIFFNNYYDPDFHKGAIYPKFYQTCLEIWRTHYDRH
...| | ||||||. |. .            .     |  .. .  .| | |...    .... . | .|... .|... |.   ..|..||. | |.
lleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayll...erkddylnplykaetekevlkpdtapaalklwralynrf
0040695 (Phosphotyrosine protein) phosphatases II 882-1260 1.1e-84 278.3 In-house 11-385 (388) alignment 
Range on Protein: 882-1260
Range on HMM: 11-385/388.0
FHFNAEMERTGIlnakigNTSLWRITTITKTNpDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSerGLQSSKLPVD
...  |..|.|.      ...||||... . . .|||||| .|||  .| | .| |  |... ||.|  ..... ||.|||| . ...  ||. |.   |
ydilrelkrlgl......gldlwrisivNeny.elcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv..glllsrsled

EAILQAIRGCNANSRLFVFTEKSDTSGFQDPNKLTKEAARSYYYHNCHFIYSvNPPTYKSVRHSFNKLQAMLQSNISDDEYMVTLDGTKWLSRVGDLLDT
| .|.||.... |.. ... .  ..  ..    | .      .| |. .|.  | | .. || |..||. .. .. ....... |. ..||. .  .|..
eklleailkllpnlskllivdlrpklnalanralgggvenedaypnaelifl.nipnihvvreslqklldaclnvpdslnllslleesgwldliklilel

AHKVVEALTVESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRsraavGGASSKIKEDGPVFLQWIDCVWQITRQ
|  .|. |. .. .|||. ..|||||.|..||||||.||||||..||||||.||||.|||.|..|...     .  ... ||  ||||...|||||..||
avlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh.....leseidskefsPvFllFLdcvwqLlrq

CPFAFEFNENLLICFMIPDHYHQ---------------SIYTNTISFWTWVSMVNSSnniFFNNYYDPDFHKgAIYPKFYQTCLEIWRTHYDRH
 |.||||||.||. ..   ....               |....|.|.|...   .|    |.| .|||. .   ..| .   .| .|   | |.
fPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkse...flnplYdpssle.vllpslsvldlllWleyylrw
subfamily_MTMR3_pd Subfamily MTMR3 883-996 4.8e-13 41.7 In-house 28-133 (442) alignment 
Range on Protein: 883-996
Range on HMM: 28-133/442.0
HFNAEMERTGILnakigNTSLWRITTITKtNPDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAatTSERGLQSSKLPVDE
....|.|| |        .. |||... . . .||.|||.||.|  .| | || .. .    .|.|.  |  |.||.|| |..    | |. . .   ||
klkeeverlGfd.....lkeawrisdvns.dfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs..qPevgwlgWrnaede

AILQAIRGCNANSR
 .|.||  . |  .
kllkaiakacalda
subfamily_MTMR9_pd Subfamily MTMR9 892-1258 5.6e-64 208.6 In-house 22-390 (393) alignment 
Range on Protein: 892-1258
Range on HMM: 22-390/393.0
GILNAKIGNTSLWRITTITKtNPDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSERglQSSKLPVDEAILQAIRGC
 ...  |  .. |||... | |  .|.||||...|   | | .|    .  |.||||  ....| ...||||..   .    .  .   ||..|... . 
nefaklisasdewRissvNk.nfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgs..sgkrckedekllnlvlkk

NanSRLFVFTEKSDTSGFQDPNKLTKEAARSYYYHNCHFIYSVnpPTYKSVRHSFNKL-QAMLQSNISDDEYMVTLDGTKWLSRVGDLLDTAHKVVEALT
.  .. ...  .| ... .   | .. . .. |..  .   |.    ..|.  |. || .|. . ..| |...  |. ..||| | |||..| .|...|.
l..kkGlivdtrsksaaenarskgggietevkysqwkkasrsl..esvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcld

VESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRSRAAVggasSKIKEDGPVFLQWIDCVWQITRQCPFAFEFNE
 | | |.|  |.| | | |..|||||. ||..||..||. ||..||.  ||||.||.|.. |.      | |..||||| ..|||.|| .| | .|||||
eegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaake....tkkklsgpvfllFLDcvyqilsqfpasFEFne

NLLICFMIPDHY---------------HQSIYTNTISFWTWVsMVNSSNNIFFNNYYDPdfHKGAIYPKFYQTCLEIWRTHYD
.|||..    ..               .. . ..|.|.|..|   ..  . |.|  |..   .  | |    ..||.|.  | 
elLillfehsyssqfgtflcdneaerkelklkkktvslwsyv.nrpeklkqflnplyea..naeviwpsvapqslelWselyl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 899-1259 2.2e-49 160.3 In-house 36-403 (405) alignment 
Range on Protein: 899-1259
Range on HMM: 36-403/405.0
GNT-SLWRITTITKTNpDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAAttSERGLQSSKLPVDEAILQAIRGCNANSRL
 .. . |..|.| |    .| ||.  ||||    | || .   .   || |. .| . |  . . |..      |.. .. | ||    ..        |
nssncywkvtsinkey.kmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsq..plvgierarcpedelycsslalsapsktl

FVFTEKSDTSGFQDPNKLTkEAARSYYYHNCHFIYsVNPPTYKSVRHSFNKLQAMLQSNISDDE--------YMVTLDGTKWLSRVGDLLDTAHKVVEaL
..   .     . .  . .      . | ||.... .| |  . .|.|..|| . ..|   | .        .  ... | |.| .  .|..|    | |
ylidarpklnaiantanga.gfenihnypncklvf.mnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsae.l

TVESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRhsrsraaVGGASSKIKEDGPVFLQWIDCVWQITRQCPFAFEFN
 .    .||    ||||| || ||.|.| ||||||. ||||||.|||| ||| |  |       .|    . .|  |.| |..||..|.  | |. ||| 
ilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslr.......lghlpgneeerspifqqfldccfqllsqfpllfeft

ENLLIcfMIP-----------------DHYHQSIYTNTISFWTWVSMvnsSNNIFFNNYYDPDFHKgAIYPKFYQTCLEIWRTHYDR
 .||.  .|                  |. .. . |.||| |. | .     | |.| ||.|.  . .| ||.|  |||.|.. | |
pslll..fisdnihsckygtflnncekdrvqdqvktktisiwsevnl...nvnkflnpyynpqdiq.sikpklysrclelwkacymr
subfamily_MTMR5_pd Subfamily MTMR5 900-970 5.6e-12 37.2 In-house 27-96 (483) alignment 
Range on Protein: 900-970
Range on HMM: 27-96/483.0
NTSLWRITTITKTNpDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSE
..  .||... |.   .| |||  .||   . |  . | .. ....|.| .||... |...|.|... .|.
krgkfrisevNkky.tvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfesk
subfamily_MTMR10_pd Subfamily MTMR10 905-1209 3e-46 149.9 In-house 25-293 (380) alignment 
Range on Protein: 905-1209
Range on HMM: 25-293/380.0
RITTIT-KTNPDLCPSYPEKLVVLLCIPDVDLLRGGRIYEEGRFPTATWMnKSNGSVLLRAAATTSERGLQSSKLpvdEAILQAIRGCNANSrlfvftek
 |   . .   . ....|...||.  . |.|. |  | |.|.|||  .|  ...|..||| .|.      .  |.   |..|. .| |...         
aivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvws.hakgaallrlsalqeaesadkeke...ekmlelvrkchpan........

sdtsgfqdpnkltkeaarsyyyhNCHF-IYSVNPPTYKSVRHSFNKLQAMLQSN------ISDDEYMVTLDGTKWLSRVGDLLDTAHKVVEALTVESAHV
                       . ..   | . |. . | ....||...   .        ||... .|. |.||  |  .| || ..|.... .   |
.......................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsv

LVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRSRAAVGGASskikedgPVFLQWIDCVWQITRQCPFAFEFNENLLICF
..  ..| |    . |||||..||.|||..||| ||||||   ||||..|  .   . .  |       ||||   |||.| ..| |..|||.| .|| .
ilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses.......pvfllFldcvdqlleqfpseFeFtetfLial

MipDHYHQSIYTN
.  |. | .|. .
w..dsshsgiflt
subfamily_MTMR5_pd Subfamily MTMR5 995-1194 1.3e-49 161.3 In-house 206-392 (483) alignment 
Range on Protein: 995-1194
Range on HMM: 206-392/483.0
SRLFVFTEKSDTSGFqdpnkltkeaaRSYYYHNCHFIySVNPPTYKSVRHSFNKL-QAMLQSNISDDE----YMVTLDGTKWLSRVGDLLDTAHKVVEAL
 .|.|. |||.  ..           .|  .... ||  |. .  . |. ||.|| .| | |. ....    .. ...   ||. .  ||. .  ||. |
aaLYvlgeksqlknv...........ksevdskaefi.pvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdll

TVESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRTMDGFQVLIQKEWLWFGHPFQSRHSRSRAAVGGASSkikedgPVFLQWIDCVWQITRQCPFAFEFN
 .. . |||..|.||| |.|..|||||| ||||||..||.||..|||| ||| |. | ..  .| . ...      |||||..|||.|..|| | |||||
dlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfa......PvFlqFLDcvhqvsrqfPlafefn

ENLLI
.  | 
dfylk
subfamily_MTMR3_pd Subfamily MTMR3 1021-1254 8.1e-54 176.0 In-house 198-436 (442) alignment 
Range on Protein: 1021-1254
Range on HMM: 198-436/442.0
RSYYYHNCHFIYsVNPPTYKSVRHSFNKLQAMLQSNISDDEYMVTLDGTKWLSRVGDLLDTAHKVVEALTVESAHVLVCYEKGWDRTTQIVSLAQLLCDP
 . ||.||. .. .. .   .||.|||.|.|.|..   . ... .|. |||| ..  || .| |||||.  |.  |||    |||||||||.||.|| ||
leeyypncevvf.lglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldp

YYRTMDGFQVLIQKEWLWFGHPFQSRhsrsrAAVGGASSKIKEDGPVFLQWIDCVWQITRQCPFAFEFNENLLICFM------------I---PDHYHQS
||||..||.||...||| ||| |. |     .. |  . . .|  ||||||.|.| |..|| | .|||||  |. ..            .    .  ...
yyrtleGfkvlvereWldfGhkfadr.....cghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek

IYTNTISFWTWVsmvNSSNNIFFNNYYDPDfHKGAIYPKFYQTCLEIWR
....|.| |...   ..... . |  |...  .  ..|..    |..|.
vkertlsvWsll...rakekeyrnllykek.teavllpavsvrelklws
subfamily_pats1_pd Subfamily pats1 1028-1147 3.9e-22 70.4 In-house 336-457 (691) alignment 
Range on Protein: 1028-1147
Range on HMM: 336-457/691.0
CHFIYsVNPPTYKSVRHSFNKLQA-MLQSNISDDEYMVTLdGTKWLSRVGDLLDTAHKVVEALTVESAHVLVCYEKGWDRTTQI---VSLAQLLCDPYYR
.. |. .. || . |.  |..|   .|. . ||||.  .    ||.  |  ||..| ||   |   |. .|    .. . . ..    ||||.| ||.||
sniif.lslPtrekveerffdllqsilsldgsddewkeie.eskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyr

TMDGFQVLIQKEWLWFGHPFQSRH
|.|||.|||.|||| .|.||. . 
tldGfkvliekewlsyGfPfskin
subfamily_pats1_pd Subfamily pats1 1165-1197 1.7e-09 28.6 In-house 553-585 (691) alignment 
Range on Protein: 1165-1197
Range on HMM: 553-585/691.0
GPVFLQWIDCVWQITRQCPFAFEFNENLLICFM
 |.|.|..| |||. .. || ||||| ||. ..
sPifvqfldlvwqlqkefPfhfefneslllllv
PH PH domain 1373-1469 1.5e-14 44.4 Pfam-A 3-100 (104) alignment 
Range on Protein: 1373-1469
Range on HMM: 3-100/104.0
CQGYLTKEGGFMKNWKRRWFVLDYvnNYVAYFESQEHySQRESPKGVIMLDDIkRVSLSTRR----IHLMSNLFQVKTPSR-TYNIKAPSIITMEIWMAC
..|||.| ..  |.||.|.|||    ||. ||.|..   ....|||.| |.|. .|   ..          | |....... .| ..|.|   .. |...
keGyllkksellktwkkryfvLts..nyLlyfksskk.ksykapkgsiplndc.tvkkasstkfgaqkesnnyfeitfknvesyllsaeseeerkrWvqa

LR
|.
lk
PH_11 Pleckstrin homology domain 1374-1468 6e-08 22.8 Pfam-A 2-109 (112) alignment 
Range on Protein: 1374-1468
Range on HMM: 2-109/112.0
QGYLTKEGGF-MKNWKRRWFVLDYvNNYVAYFES-------------QEHYSQRESPKGVIMLDDIKRVSLSTRRIHLMSNLFQVKTPSRTYNIKAPSII
.||| | |   .| ||||||.|   .|   |..|             .| ..  .. . .. |. |. .     . . .|| |......... .|. .  
kGylkkkgskllkgWkrrwfiLrk.dnvleYyksprdksdvalitkesekvilkkdlsisnrlskianikdkkalelshsnefsiaaeekslflkgdnne

TMEIWMACL
..| |.  |
eteeWveal