Gene MTMR1-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP024_AA protein Get Run
AqueP024_AA_375-738 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
C2 C2 domain 10-62 1.2e-16 48.4 Pfam-A 1-56 (85) alignment 
Range on Protein: 10-62
Range on HMM: 1-56/85.0
LRVEVLKARDLAPADTNGKSDPYCIVSLGQ---KVVQTSVQPQTLFPEWMQSMAFF
|.|.|..|..| . | ||.||||. ||||.   |  .|.| ..|| | |.... | 
LkvkvieAknLpnkdkngtsdpyvkvslggakskkkrTrvikntlnPvWnekftfe
Myotub-related Myotubularin-like phosphatase domain 365-682 7e-99 323.9 Pfam-A 8-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 365-682 7e-99 323.9 In-house 8-352 (353) alignment
subfamily_MTMR6_pd Subfamily MTMR6 369-735 3.7e-94 308.2 In-house 11-396 (397) alignment 
Range on Protein: 369-735
Range on HMM: 11-396/397.0
TELKLKTDWNVeAQLHTDMARMM--SDNWKESPLNCLYTLCPTYPPVVYIPKVV-------------RGRVPSLVWMDKVNGTFLLRSAQPLPGLSDkHS
.. . .. |.   .|.....||   ...|... ||  |.|| |||  .|.|| .             .||.| | .. | | . . |..||| |.|   .
dkeekvsGwkl.ldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.rc

TEDETLLKYAITCYE-GEGLMIFDARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYEGLKQLA--LSTSSTRWYSSLESTQWIEYISLI
.|||.||.   ..    | |.. |.|    |  |.. ||| |. . |  .|.  ..| ||| .||| . | . .   |.| . ..|.|||..|. .|  .
ledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikav

LKGSYLIARLIKIHSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGHP-LNPNERSPIFLQFLDCVHQLMNQYPHA
|. | .||. .. .  | |.||||||||||| .||.....|.|||||.||| || |||||.||||.|| |.   .. | ||||.|||.|| ||..|.|.|
ldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpka

FQFNLSFLLTIAEHLNTGWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNYRETKE--IIMPTWTIRRLRLWEEYFLAWD
|.|| .|||.. .|. .  ||||| ||.|.| .. .   |  . |.. . .| |.|  |....|  ...|  .  .|.||   .  .|
fefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwralynrfd
subfamily_MTMR3_pd Subfamily MTMR3 373-463 2.8e-10 32.6 In-house 19-125 (442) alignment 
Range on Protein: 373-463
Range on HMM: 19-125/442.0
LKTDWNVEAQLHTDMARM---MSDNWKESPLNCLYTLCPTYPPVVYIPKVVR-------------GRVPSLVWMDKVNGTFLLRSAQPLPGLSDKHSTED
|...  .| .|.....|.   ....|. | .|  . ||..||  . .||..              .|.|..||  | ||. | |..||  |.    ..||
lraasvaeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaed

ETLLKYA
|.||| .
ekllkai
subfamily_MTMR1_pd Subfamily MTMR1 374-736 2.1e-153 503.2 In-house 3-388 (389) alignment 
Range on Protein: 374-736
Range on HMM: 3-388/389.0
KTD-WNV-EAQLHTDMARMMSD-NWKESPLNCLYTLCPTYPPVVYIPKVV-------------RGRVPSLVWMDKVNGTFLLRSAQPLPGLSDKHSTEDE
|.| |.| ... .......... .|... ||. |.||.|||.|...||||             .||.|.|.|..| |....||..||| |||.|.|.|||
kedGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskede

TLLKYAITCY-EGEGLMIFDARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYEGLKQLAL-STSSTRWYSSLESTQWIEYISLILKGSY
..|....... . | |.|.|||||..|..|...|||.|. ..|....|..|||.|||.||||.. ||.|.| ......|.|.||||.|.|.|.|||.|..
kylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagav

LIARLIKIHSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGH---PLNPNERSPIFLQFLDCVHQLMNQYPHAFQF
 |.. ..... |.|.|||||||||||||||.....|||||||.|| .||.|||||.||||||||||   . ...||||.||||.|||.||..|.|.||.|
kivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFef

NLSFLLTIAEHLNTGWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNYRET--KEIIMPTWTIRRLRLWEEYFLAWDG
| .||.|...||....|||||||..|||....|  .||......|.... ..| .|.|.  |....|....|||.||.||.|.|..
neefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwnp
0040695 (Phosphotyrosine protein) phosphatases II 376-735 1e-114 377.1 In-house 6-386 (388) alignment 
Range on Protein: 376-735
Range on HMM: 6-386/388.0
DWNVEAQLHTDMARMMS--DNWKESPLNCLYTLCPTYPPVVYIPKVV-------------RGRVPSLVWMDKVNGTFLLRSAQPLPGLSDKHSTEDETLL
. ...     .. |.    | |. | .|. |.|||.||.....|| .             .||.| |... . ||  ||||.|||.||. . | ||| ||
egwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekll

KYAITCY-EGEGLMIFDARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYEGLKQLALST-SSTRWYSSLESTQWIEYISLILKGSYLIA
.. .... . . |.|.|.|.   |. ||..|.|.|  ..|. ..| .|.||||| ||||.  | .. |.. .|....|.||...|...|.|||....||.
eailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslleesgwldliklilelavliv

RLIKIHSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGH---PLNPNERSPIFLQFLDCVHQLMNQYPHAFQFNLS
.|..  . | |.|||||||||.||.||.|...|.||||..||..||.|||||.|||| .||||     ...|.||.||.|||||.||..|.|.||.||  
klldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFner

FLLTIAEHLNTGWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNYRETKE-IIMPTWTIRRLRLWEEYFLAWD
.||..|.|| ...|||||||..|||.|..|. .|...  ... ......|..|  ... ...| . .. |.|| ||.| |.
lLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllpslsvldlllWleyylrwl
subfamily_MTMR9_pd Subfamily MTMR9 384-734 3.2e-75 245.6 In-house 21-392 (393) alignment 
Range on Protein: 384-734
Range on HMM: 21-392/393.0
HTDMARM--MSDNWKESPLNCLYTLCPTYPPVVYIPKVV-------------RGRVPSLVWMDKVNGTFLLRSAQPLPGLSDKHSTEDETLLKYAITCYe
. ..|..   ||.|. |  |  ...|..||. | .|| .              ||.| | ...| ... ||||.||| | | |.  |||.||. ...   
enefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkkl.

GEGlMIFDARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYEGL--KQLALSTSSTRWYSSLESTQWIEYISLILKGSYLIARLIKIHSG
  | .|.| ||.|||. .|  | | |  ..|.  | .. .. ... . .|.  |  .  ....|. ...| ||...|.. .  .|. .  .| ... .  
kkG.livdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeega

SALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGHPLNP----NERSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAE
. ..| ..| | | |.|||.|.|.|...||..||  || .||.  || |..|  .        ....|.|| |||||.|...|.| .| || ..| .. |
pvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfe

HLNTGWFGTFLFNCHKERIENDVFVSTVPITAHFNA--MRDVYINLNYRETKEIIMPTWTIRRLRLWEEYFLAW
|  .  ||||| ....|| |...   || . .. |.   .. ..|. | ...|.|.|      |.||.| .| |
hsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyeanaeviwpsvapqslelWselylrw
subfamily_MTMR10_pd Subfamily MTMR10 390-703 2.8e-50 163.2 In-house 21-325 (380) alignment 
Range on Protein: 390-703
Range on HMM: 21-325/380.0
MMSDNWKESPLNCLYTLCPTYPPVVYIPKVVR-------------GRVPSLVWMdKVNGTFLLRSAQPLPGlSDKHSTEDETLLKYAITCYEGEglmifd
  ||... .  | | . ..|.|. ...|. .              .| | .||  . .|. ||| ..  .  ....  . |. |  .  |  ..      
tvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvws.hakgaallrlsalqea.esadkekeekmlelvrkchpan......

arsssaatgnrimgkgtedvsryyRCKL--THLDIPNIHAVRESYEGLKQLALSTSST-------RWYSSLESTQWIEYISLILKGSYLIARLIKIHSGS
                          ||  .. ..|.|. | ..|. |..| .  .|.       .|.||||.|.|..|..|.|. .. .....  .  |
........................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrs

ALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGHPLN-PNERSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHLNT
 ..  |.| |    . ||.|...|..||||.|| .|| ||| . ||.| .||||  . ....||.|| |||||.||..|.|..|.|. .||...  . ..
vilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshs

GWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVY
| |.|||||. ..| .. |  | ..|. ..    |..
gifltflfnseeqrlkavvsssplliakselkendll
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 391-734 2.9e-104 341.4 In-house 31-402 (404) alignment 
Range on Protein: 391-734
Range on HMM: 31-402/404.0
MSD-NWKESPLNCLYTLCPTYPPVVYIPKVV-------------RGRVPSLVWMDKVNGTFLLRSAQPLPGLSDKHSTEDETLLKY-AITCYEGEGLMIF
.|. .|. | .|  |.||.||| .. .|. .             .||.| |.|  . ... . ||.||| ||. ..|.|||.|..   ... ..| |.| 
kseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirkaktqletlyil

DARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYEGLKQLALSTSST--RWYSSLESTQWIEYISLILKGSYLIARLIKIHSGSALIHCS
|||..  |. |. .|.| ||.|||. |..  | | ||| .|||.. ||... |. .    |.| |||..|.. |.|.|.||  |..||. .. | |.|||
darpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcs

DGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGH--PLNPNERSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHLNTGWFGT
||||||.||.||.|...|.||||| ||  || |||||.||||..| |.    . .|||||||||.|||.||..|.|. |.|| .||..| ..|. . |||
dgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgt

FLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNY----RE-TKEIIMPT----WTIRRLRLWEEYFLAW
||....||| .|..   || . |  .| .. |.| .|    .| ...| . .      |....||.||.| |
FLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessssadikliklWseyylrw
subfamily_MTMR5_pd Subfamily MTMR5 392-444 7.8e-07 20.2 In-house 28-93 (483) alignment 
Range on Protein: 392-444
Range on HMM: 28-93/483.0
SDNWKESPLNCLYTLCPTYPPVVYIPKVVR-------------GRVPSLVWMDKVNGTFLLRSAQP
..... |  |  ||.| .|| .. .|. |              .|.|  .|... |.. |.||...
rgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 421-732 3.4e-77 251.9 In-house 81-402 (405) alignment 
Range on Protein: 421-732
Range on HMM: 81-402/405.0
RGRVPSLVWMDKVNGTFLLRSAQPLPGLSDKHSTEDETLLKYAITCYEGEGLMIFDARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYE
.||.||| | |    . . | .||| |.   .  |||              | . |||    |  |   | | |..  |  |||  ..||||| .| | |
kgripslswkdpssnasisrcsqplvgierarcpedelycsslalsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksle

GLKQLALS-------TSS--TRWYSSLESTQWIEYISLILKGSYLIARLIkIHSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSY
 |     |       | |   |..  .| | || .|  ||. . . | || ..  | |.||||||||| |.||||||..| ||||| ||  || |||||.
klvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsf

GHKFKERLGH-PLNPNERSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHLNTGWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNYRE
||||  |||| | | .|||||| |||||. ||..|.|  |.|  |.|| |.. . .  .|||| || |.|....| . |. | .  |   . ..|  |  
ghkfslrlghlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynp

T-KEIIMPTWTIRRLRLWEEYFL
   . | |    | | ||   ..
qdiqsikpklysrclelwkacym
subfamily_MTMR3_pd Subfamily MTMR3 469-732 2.8e-90 296.2 In-house 172-440 (442) alignment 
Range on Protein: 469-732
Range on HMM: 172-440/442.0
GEGLMIFDARSSSAATGNRIMGKGTEDVSRYYRCKLTHLDIPNIHAVRESYEGLKQLAL-STSSTRWYSSLESTQWIEYISLILKGSYLIARLIKIHSGS
 . |.| |||| .|| .||  | | |    |  |....|...||||||.|.. |..|   |. ...|.|.||.|.|.. .| .|| .  ..  .. .. .
kkkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrp

ALIHCSDGWDRTAQLTSLTQIIIDSYYRTIDGFLTLIAKEWLSYGHKFKERLGHPLN---PNERSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHL
 |.|||||||||.|...|.....| ||||..||  |. .|||..||||..| ||  |    |||.|.|||.||.|||| .|.| .|.|| .||. ...| 
vlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqht

NTGWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNYRE-TKEIIMPTWTIRRLRLWEEYFL
 .. |||||.|..||| |. |   |. . . ..|  . | || |.| |. ...|. ..| |.||.| .|
ysclfGtflansekereeekvkertlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyl
subfamily_pats1_pd Subfamily pats1 497-621 4.9e-25 80.0 In-house 331-459 (691) alignment 
Range on Protein: 497-621
Range on HMM: 331-459/691.0
SRYYRCKLTHLDIPNIHAVRESYEGLKQ--LALSTSSTRWySSLESTQWIEYISLILKGSYLIARLIKIHSGSALIHCSDGWDRTAQL---TSLTQIIID
..   ...  |..|  . |.| .  | |  | |  |   | ...|  .|.. . |.|...  .. |.   |   |   .|. . . .|   .||.|.. |
fkmissniiflslPtrekveerffdllqsilsldgsddew.keieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsd

SYYRTIDGFLTLIAKEWLSYGHKFKERLGH
 .|||.|||. || |||||||. |...  |
PfyrtldGfkvliekewlsyGfPfskinyh
subfamily_MTMR5_pd Subfamily MTMR5 499-689 7.5e-56 181.9 In-house 225-423 (483) alignment 
Range on Protein: 499-689
Range on HMM: 225-423/483.0
YYRCKLTHLDIPNIHAVRESYEGLKQLALSTSS------TRWYSSLESTQWIEYISLILKGSYLIARLIKIHSGSALIHCSDGWDRTAQLTSLTQIIIDS
. .. .  .....| .|. |.. | .  |.  .      . ...|.|  .|.. || .|. |  .. |. ..  | |.   |||| |||..||.|...|.
dskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldp

YYRTIDGFLTLIAKEWLSYGHKFKERLGHPLNPNE--RSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHLNTGWFGTFLFNCHKERIENDVFVST
||||..|| .|. ||||..||.|..|  . |. ..   .|.||||||||||...|.| || ||  .| ..| |  .  | |||... .||.|...... 
yYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyee
subfamily_MTMR14_pd Subfamily MTMR14 554-620 3.2e-07 21.5 In-house 254-329 (357) alignment 
Range on Protein: 554-620
Range on HMM: 254-329/357.0
SYLIARLIKIHS---GSALIHCSDGWDRTAQLTSLTQIII------DSYYRTID-GFLTlIAKEWLSYGHKFKERLG
 || . |  ...   .  |.||  |||||   .|| .. .          ....  .|| .| .|. .||....|| 
nylklllkyvkededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellylt.vaydWflfghqlpdrlk
PTPc_DSPc_SM00012 559-663 8.9e-11 37.3 In-house 38-103 (105) alignment 
Range on Protein: 559-663
Range on HMM: 38-103/105.0
RlikihSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRTidgfltliakewlsyghkfkerlghplnpnerspIFLQFLDCVHQLMNQYPHAFQFNLSFLL
.     |.. ..|||.|..||.... |  .. . ...|                                   .......|..|..| |...|..  .| 
s.....skpvvVhCsaGvgRtgtfvaldillqqleket..................................kevdifqivkelrkqRpgmvqteeqylf

TIAEH
 .. .
lyral
subfamily_pats1_pd Subfamily pats1 629-711 2.3e-19 61.2 In-house 553-635 (691) alignment 
Range on Protein: 629-711
Range on HMM: 553-635/691.0
SPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHLNTGWFGTFLFNCHKERIENDVFVSTVPITAHFNAMRDVYINLNYRET
||||.|||| | ||  ..|  |.|| |.||.. ..  .. ||.||..  |.. |..|. ..  | .  |  .  .||| |...
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhs