Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
uDENN | uDENN domain | 39-100 | 5.8e-11 | 31.7 | Pfam-A | 1-64 (65) | alignment | ||
Range on Protein: 39-100
Range on HMM: 1-64/65.0
KPRVCQRFPTENR-ASGSLPAGIELFCRSQGWCLTSHP-PPPSFNNFILTSELGSHFYCCSLNF
||.. ..|| .. || |..|| .|. ... ..|.| |.||.| || .|...|.|
kpkildqfPekdeeedeplpkaipmFCfPeglnfvtsreqkpeffsfvLTdedgsriyGfClrf
|
|||||||||
DENN | DENN (AEX-3) domain | 186-383 | 9.5e-28 | 86.6 | Pfam-A | 3-184 (185) | alignment | ||
Range on Protein: 186-383
Range on HMM: 3-184/185.0
PLSLCLVAKYPIYDALQVLLKSIYIHHVMGDTldkfsssqlpvsphsTTMEELISELLIDLRFPLPGKPLVKRSFGPLKELTLVPLNiMETIPYTSDNTY
| .||.. ..|...... .|| .. .. ... ..|..|..|| . .| |||.|. | . ....| . ...| .. . .
pkalcilsrlpffelfkkiLkalekrlksssk...............lplesfianlllevplPapgktlklkslsvkekillqrps.sselPledvdle
RLLKAIGVHGLLQLFSLILVDGKLLFISSSITAITSAIISVVSLMYPIGIDHFSCLLIPSGFVEYLHCITPFLMGLHRSLLVELDEEPLDVTLVDLDS
|....... .||||...|.. .....|.... .||.. ..|.|.||. | ..|. ....|.. |||..|...||| ..... ||.|||||.
elfrcLsienvlqlfeavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslleleekpledvvlvDldt
|
|||||||||
dDENN | dDENN domain | 437-496 | 3.2e-08 | 22.8 | Pfam-A | 2-58 (68) | alignment | ||
Range on Protein: 437-496
Range on HMM: 2-58/68.0
DKAVRSVFINVFLYLLGTYQHHVTVVRFHPEpkFHFDKESYIAQfCSGDDSDVWKAFINT
|..|| .| ..| |||.|..... | .|| .|.||... . | ... ..|..|
dqqvreaFlrffasllggYrnflrkerkspe..vsFqkeaFlks.rskshrsFlsqflet
|
|||||||||
SBF2 | Myotubularin protein | 604-757 | 1.3e-35 | 112.0 | Pfam-A | 11-171 (225) | alignment | ||
Range on Protein: 604-757
Range on HMM: 11-171/225.0
STHRRVSNSLMRDVELLHKFLDALFSSRILEARKYFPSVTMSLRQRVTTPIFIPELVNKLMRNGAYLSPDQFEVMVRLVNCALVDE------KIAMQILP
... . .. | .| |.. . .| ..||||.| .| | .|... . ... || .. .| | | .||...|||.|.|| |. .| ..||
ektkstvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakdeygvaaallp
LTSVFYQEIQPGVNQYLYSCIQSHRLWQSTRFWCHSLYSAIQAELVRLYADvpfkkekP--------K
|.|.|. . .||.|. |.|.| | .|....|| .. |. .|... || . |
lssafcRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelyle.......kkseskkkkk
|
|||||||||
GRAM | GRAM domain | 978-1041 | 1.1e-08 | 25.9 | Pfam-A | 15-66 (69) | alignment | ||
Range on Protein: 978-1041
Range on HMM: 15-66/69.0
IIEGIRSFLLRDgrdtggrLVPAHGHVYLTSYRIVFLGSPWDPEVdpnvlVTRSMPISSIYRMK
... .. | .. ..|. |..|||.||..| ... |... |....|...| |..
llddyaCylsts.......kgpvqGrlYlTnyrliFrSdklddsk.....vvvvipladikrve
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 1156-1246 | 1.3e-21 | 69.7 | Pfam-A | 21-103 (353) | alignment | ||
Range on Protein: 1156-1246
Range on HMM: 21-103/353.0
LSQSPYCIEYDRLGLGSLNFsvsksrgqWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASF
|... .. || |||| | . ||.|..|....|||.||| ..|| . ||| .... ....|.|.... |....| |.||.
lkiedlekeykrlglssska........wriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyrhkengavlvRssqp
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 1156-1246 | 1.3e-21 | 69.7 | In-house | 21-103 (353) | alignment | ||
Range on Protein: 1156-1246
Range on HMM: 21-103/353.0
LSQSPYCIEYDRLGLGSLNFsvsksrgqWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASF
|... .. || |||| | . ||.|..|....|||.||| ..|| . ||| .... ....|.|.... |....| |.||.
lkiedlekeykrlglssska........wriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyrhkengavlvRssqp
|
|||||||||
subfamily_MTMR5_pd | Subfamily MTMR5 | 1157-1261 | 8e-39 | 125.7 | In-house | 6-108 (483) | alignment | ||
Range on Protein: 1157-1261
Range on HMM: 6-108/483.0
SQSPYCIEYDRLGLGSLNFSvsKSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSR
. |...|.|||||.||.. ..||..|.|..||..|.|..|||..|||...||.||.|. ..|.|.|.|.|||.|.|.||.|.||..|.. |. .
aerayvqdykRlGlgalnga..skrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgllk
RVILT
. .
santq
|
|||||||||
0040695 | (Phosphotyrosine protein) phosphatases II | 1158-1257 | 3.4e-22 | 72.7 | In-house | 10-100 (388) | alignment | ||
Range on Protein: 1158-1257
Range on HMM: 10-100/388.0
QSPYCIEYDRLGLGSlnfsvsksrGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSRR
.. |. ||||| ||.|..|. ..||..|||..||| ||| . |.. ....||.|.....||...| ||||. . .... ..|
lydilrelkrlglgl.........dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsle
|
|||||||||
subfamily_MTMR3_pd | Subfamily MTMR3 | 1162-1244 | 5.7e-15 | 48.0 | In-house | 30-104 (442) | alignment | ||
Range on Protein: 1162-1244
Range on HMM: 30-104/442.0
CIEYDRLGLGslnfsvskSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSA
.|..|||. ...||.|..|..| ||..|| .|| . .|..... .. .|.| | |.| ...|.| |..
keeverlGfd........lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
|
|||||||||
subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 1164-1245 | 1e-18 | 59.7 | In-house | 24-97 (404) | alignment | ||
Range on Protein: 1164-1245
Range on HMM: 24-97/404.0
EYDRLGLGSLNfsvsksrgQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSAS
|| |||. | .||.|.||. ..|||||| . ||| . ||| .... . ..||.|...|.|. ... . ||.
EykRlgikses........eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssq
|
|||||||||
subfamily_MTMR1_pd | Subfamily MTMR1 | 1164-1252 | 1.4e-17 | 56.1 | In-house | 15-95 (389) | alignment | ||
Range on Protein: 1164-1252
Range on HMM: 15-95/389.0
EYDRLGLGSLNfsvsksrgQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQ
|..|||| . . .|| ...||...||.|||||.||| ||| . .. ..||.|...| .....|..||.. .|.
elerlgllnek........lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsg
|
|||||||||
subfamily_MTMR10_pd | Subfamily MTMR10 | 1178-1267 | 1.2e-13 | 42.6 | In-house | 20-109 (380) | alignment | ||
Range on Protein: 1178-1267
Range on HMM: 20-109/380.0
SKSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSRRVILTKHGSSE
... ... .. |. |. ..|.| |||.. ||. . |.. |....| |. .|.|....| |. ||. .. . .. ...| . ...
ktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelvrkch
|
|||||||||
subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 1179-1243 | 1.2e-10 | 32.7 | In-house | 37-101 (405) | alignment | ||
Range on Protein: 1179-1243
Range on HMM: 37-101/405.0
KSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRS
.| |....||| . .| .|.. || .| | . .|. .||.| ..|| | ..| . |
ssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrc
|
|||||||||
subfamily_MTMR9_pd | Subfamily MTMR9 | 1180-1245 | 2e-16 | 52.1 | In-house | 30-95 (393) | alignment | ||
Range on Protein: 1180-1245
Range on HMM: 30-95/393.0
SRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSAS
. .||.|..|| |..|..||. .||.. .||.. . . ..||.|. .. | .||| ||||.
asdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssq
|
|||||||||
subfamily_MTMR6_pd | Subfamily MTMR6 | 1182-1245 | 3.3e-08 | 25.2 | In-house | 36-99 (397) | alignment | ||
Range on Protein: 1182-1245
Range on HMM: 36-99/397.0
GQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSAS
.| |. .||...||.||| .|| . . | . .||.|.... | ...| . |..
ekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsq
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 1183-1283 | 1.4e-08 | 25.6 | In-house | 25-123 (691) | alignment | ||
Range on Protein: 1183-1283
Range on HMM: 25-123/691.0
QWRLSTINKSfTLCETYPAVWVVPDKFSDESITRILpHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSRRVILTKHGSSEKISDSDLLGIQSADI
.|| .. .. |.| || .||. ||| . . .. ..|...| .. |. |.| . ...|. . |. | | . .. .|. |
dwrvveflsr.dlseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnnksslfricvynqpfnnkfnsggtlaynnnstiinnnsviitrsssi
E
|
e
|
|||||||||
subfamily_MTMR5_pd | Subfamily MTMR5 | 1539-1723 | 3.4e-83 | 272.1 | In-house | 194-378 (483) | alignment | ||
Range on Protein: 1539-1723
Range on HMM: 194-378/483.0
DALQEEIKDWKLLGLYVIGEKSSLVNVPTDIYPNCTLLPVEISSHVDIGNSFTKLMRACCPSGASSSTTHQSkFYSLVEDSDWINQLSSLLQLSGAVADL
.| ... . .. |||.|||| | || .... .. ..|||. .. .||.||.|||.|| |......|| |...||||.|..|.||||||||||.||
nakeskklrarkaaLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqs.FlksvedseWlqqissllqlsgavvdl
MDAQGSSVLVGLEDGWDATAQVVSLAQLLMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSSG-AISPVFLQFLDCVHQEML
.|.|||||||.||||||.||||.||||||.||||||..||..|.||||||.|| ||.||.|..|... ...|||||||||||| .
ldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsr
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 1558-1722 | 2.6e-54 | 177.3 | Pfam-A | 149-313 (353) | alignment | ||
Range on Protein: 1558-1722
Range on HMM: 149-313/353.0
EKSSLVNVP-TDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgASSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDA
.|. | .. |....|....|.. . .|..||..|| .......|||.| .|.|.|....||||. | .|..|.. ..||||| ..||||
nkakgggveseenysqaelvflgienihvvreslkklreac....keaneeseskflsslesskWLkhisslLkasalvvklveseessVlvhcsdGwDr
TAQVVSLAQLLMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQI---QSSSGAISPVFLQFLDCVHQEM
|||||||||||.||||||..|| .|.|||||. ||.|..|... ..|| . |||||||||||.| .
taqvvslaqllldpyyRtieGfqvLvekeWlsfGhkFaeRvghlkenkksskesspvFlqFlDcvyqll
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 1558-1722 | 2.6e-54 | 177.3 | In-house | 149-313 (353) | alignment | ||
Range on Protein: 1558-1722
Range on HMM: 149-313/353.0
EKSSLVNVP-TDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgASSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDA
.|. | .. |....|....|.. . .|..||..|| .......|||.| .|.|.|....||||. | .|..|.. ..||||| ..||||
nkakgggveseenysqaelvflgienihvvreslkklreac....keaneeseskflsslesskWLkhisslLkasalvvklveseessVlvhcsdGwDr
TAQVVSLAQLLMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQI---QSSSGAISPVFLQFLDCVHQEM
|||||||||||.||||||..|| .|.|||||. ||.|..|... ..|| . |||||||||||.| .
taqvvslaqllldpyyRtieGfqvLvekeWlsfGhkFaeRvghlkenkksskesspvFlqFlDcvyqll
|
|||||||||
0040695 | (Phosphotyrosine protein) phosphatases II | 1566-1720 | 1e-50 | 166.6 | In-house | 141-291 (388) | alignment | ||
Range on Protein: 1566-1720
Range on HMM: 141-291/388.0
PTDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgasSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQ
..| |||..|....| . . .|. ||..|| .. ....||.|.|.|.......|.|. ...|.| ..||||| .|||| |.|..||||
nedaypnaeliflnipnihvvreslqklldac......lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaq
LLMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQS--SSGAISPVFLQFLDCVHQ
||.||||||..||. |||||||..||.| ||. . | .| .|||||.|||||.|
llldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwq
|
|||||||||
subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 1567-1727 | 2e-43 | 141.1 | In-house | 151-308 (404) | alignment | ||
Range on Protein: 1567-1727
Range on HMM: 151-308/404.0
TDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgaSSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQL
.. | ||.. |. .. .|. || |. .|.........| .|.| |......||. | ...|.. ..||||| ||||.|.|..||.||
isryenceieflnienihelreslkklkkav.....nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsql
LMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQ-IQSSSGAISPVFLQFLDCVHQEMLR-PHS
|.||||||..|| ||||||| .|| |..|. | . || ||.||||.|||.| . . |.|
lldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfpts
|
|||||||||
subfamily_MTMR3_pd | Subfamily MTMR3 | 1567-1720 | 1.4e-42 | 139.0 | In-house | 199-348 (442) | alignment | ||
Range on Protein: 1567-1720
Range on HMM: 199-348/442.0
TDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgasSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQL
.. |||| . .... . .|| .| . |.....|...| .| |...|| ||. . |.. .| .| .||| |||| |.|.|.||.|
eeyypncevvflglanihavrksfnslrall......sqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakl
LMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQS--SSGAISPVFLQFLDCVHQ
|.||||||..|| .|.|.|||..|| |.||. . . .. .|||||.||.|||
lldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhq
|
|||||||||
subfamily_MTMR1_pd | Subfamily MTMR1 | 1568-1741 | 4.5e-46 | 149.9 | In-house | 143-313 (389) | alignment | ||
Range on Protein: 1568-1741
Range on HMM: 143-313/389.0
DIYPNCTLLPVEISSHVDIGNSFTKLMRACCPSgassstTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLL
. | |..|. ..|.. . .|. || .. |. ....|..| .|.. |.......|. . .... .. . .|||| .|||| |||..|||.||
eaYknaelifldihnihvvReslkklkelvlpn......vddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamll
MDPYYRTMKGFCALIEKEWLALGHPFTDRSCQ--IQSSSGAISPVFLQFLDCVHQEML-RPHSYQANLDIWVFYTED
.|.||||..|| |||||||. ||.|..| . .|| |||||||.|||.| . |. .. | .. .. .
lDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldh
|
|||||||||
subfamily_MTMR6_pd | Subfamily MTMR6 | 1568-1731 | 1.7e-42 | 138.1 | In-house | 153-312 (397) | alignment | ||
Range on Protein: 1568-1731
Range on HMM: 153-312/397.0
DIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgaSSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLL
| | |. . |.| . .| .||. .. ... .|.|.| .|.|.|. . ..|. | .| . .| |||| |||| ||||.|||.||
dnysnikfqfvgienihvmreslqkllevv.....elksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasll
MDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSSGAISPVFLQFLDCVHQEML-RPHSYQAN
.||||||.||| |||||||..|| |..|. .....| .||.|.|||.|| | . .|.... |
ldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefn
|
|||||||||
subfamily_MTMR9_pd | Subfamily MTMR9 | 1569-1722 | 5.6e-39 | 126.3 | In-house | 148-299 (393) | alignment | ||
Range on Protein: 1569-1722
Range on HMM: 148-299/393.0
IYPNCTLLPVEISSHVDIGNSFTKLMRACCPSGASsstthQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLLM
|.. . ...|. | .|..||. || | | ..||.| .| | |..|. ||... ||...| .|..|.| |.| ||| ||.|||||..
kysqwkkasrslesvasiqdslaklleacsdagls.....tdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlil
DPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSS---GAISPVFLQFLDCVHQEM
||..||..||.||||.||. ||||. | .. .. .|||| |||||.| .
dpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqil
|
|||||||||
subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 1569-1721 | 7.3e-35 | 112.5 | In-house | 158-311 (405) | alignment | ||
Range on Protein: 1569-1721
Range on HMM: 158-311/405.0
IYPNCTLLPVEISSHVDIGNSFTKLMRACCPSGASSSTTH--QSKFYSLVEDSDWINQLSSLLQLSGAVADLMdAQGSSVLVGLEDGWDATAQVVSLAQL
|||| |. ..| | .|. ||. | | | . .|. .|.. || .. |.|. . |.|. .| |.|| |||| | |. ||.|.
nypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltqi
LMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSSGAISPVFLQFLDCVHQE
|.||||||..|| |||||||..|| |. | .. ||.| |||||. |
lldpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspifqqfldccfql
|
|||||||||
subfamily_MTMR10_pd | Subfamily MTMR10 | 1580-1722 | 3.6e-38 | 123.3 | In-house | 123-265 (380) | alignment | ||
Range on Protein: 1580-1722
Range on HMM: 123-265/380.0
ISSHVDIGNSFTKLMRACCPSGASSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLLMDPYYRTMKGFC
. | |..... ||.. | .. | . |..|. | . |.. . .|... ..... .. ||.. ..| | | |||||..||.|||..||.
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq
ALIEKEWLALGHPFTDRSCQIQSSSGAISPVFLQFLDCVHQEM
||.||| |.||||.|| .|..|... ||||| |||||.|..
sliqkewvaaghpfldrlghikpseksespvfllFldcvdqll
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 1612-1697 | 2.3e-19 | 61.2 | In-house | 369-457 (691) | alignment | ||
Range on Protein: 1612-1697
Range on HMM: 369-457/691.0
FYSLVEDSDWINQLSSLLQLSGAVADLMDaQGSSVLVG-LEDGWDATAQV---VSLAQLLMDPYYRTMKGFCALIEKEWLALGHPFTDRS
.. .|.| |.. . ||. . |. |.| .|||||. |. . . .. ||||.|.||.|||. || ||||||| |.||....
ewkeieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskin
|
|||||||||
C1_1 | Phorbol esters/diacylglycerol binding domain (C1 domain) | 1907-1956 | 4.3e-07 | 19.6 | Pfam-A | 1-51 (53) | alignment | ||
Range on Protein: 1907-1956
Range on HMM: 1-51/53.0
HSFQSFKVGSTQYeCSYCHHII--RDKDAFKCKNCSGTCHNYCKRHMPSNCG
| .. .. .... |..| .. | ..||..|. ..|. | ...|..||
Hhwvhrnfkqptf.CkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecg
|
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PH | PH domain | 2002-2106 | 3e-11 | 33.8 | Pfam-A | 2-102 (104) | alignment | ||
Range on Protein: 2002-2106
Range on HMM: 2-102/104.0
ELEGFLFKKGGVVKNWKERYFVLNLekGNLAYYESDKR--GAKLCGTIALEAIsKVEECDPIVVpstiLKSGQVGYFFKLTTNRR-VFTLMTFRTSTRSQ
..||.| ||.. |.||.|||||. ..| |..|.|. ... |.| |. . .|.... ... . . |..|.. . ..| . |..
ikeGyllkksellktwkkryfvLts..nyLlyfksskkksykapkgsiplndc.tvkkasstkf....gaqkesnnyfeitfknvesyllsaeseeerkr
WIRKLTDS
|...| ..
Wvqalknl
|
|||||||||
PH_11 | Pleckstrin homology domain | 2004-2052 | 1.9e-06 | 17.9 | Pfam-A | 2-52 (112) | alignment | ||
Range on Protein: 2004-2052
Range on HMM: 2-52/112.0
EGFLFKKGGV-VKNWKERYFVLNLeKGNLAYYES--DKRGAKLCGTIALEAI
.|.| ||| .| ||.|.|.| . | ||.| || . .| . ..|
kGylkkkgskllkgWkrrwfiLrk.dnvleYyksprdksdvalitkesekvi
|
|||||||||
PH_8 | Pleckstrin homology domain | 2013-2053 | 2.4e-07 | 20.5 | Pfam-A | 10-51 (89) | alignment | ||
Range on Protein: 2013-2053
Range on HMM: 10-51/89.0
VVKNWKERYFVLNLEKGNLAYYESDKRGaKLCGTIALE--AIS
.... |.|||.|....| ||..|. . .| | |.|. .||
klqgyakRfFvLdlksstlsYyrddnss.alrgkiplslaiis
|