Gene OCA-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP036_AA protein Get Run
AqueP036_AA_1-141 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0046845 (Phosphotyrosine protein) phosphatases II 2-68 2.2e-07 26.0 In-house 172-241 (284) alignment 
Range on Protein: 2-68
Range on HMM: 172-241/284.0
FTSSQDYTVNLSFVIKPAFCGMLKLLLSH-EENLPVLIHCVYGKDRTGVLVALILDCIGVERETI--AMD
.||  |. |  |. .  .|. ... ||.. . . |...||  |. |||...|| | .  .|.| .   .|
ytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd
0036941 (Phosphotyrosine protein) phosphatases II 3-62 2.3e-07 25.9 In-house 176-236 (297) alignment 
Range on Protein: 3-62
Range on HMM: 176-236/297.0
TSSQDYTVNLSFVIKPAFCGMLKLLLSHE-ENLPVLIHCVYGKDRTGVLVALILDCIGVER
|.  |. |  |. .  .|. ...  |..  .. |||.||. |. |.|...|. | .  .|.
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqled
0051299 (Phosphotyrosine protein) phosphatases II 3-67 2.4e-07 26.0 In-house 190-252 (288) alignment 
Range on Protein: 3-67
Range on HMM: 190-252/288.0
TSSQDYTVNLSFVIKPAFCGMLKLLLShEENLPVLIHCVYGKDRTGVLVALILDCIGVEREtIAM
|.  |. |  |.    .|. ...  |.   . ||..||  |..|||...|| | .  .|.|   .
tnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqleke.ggv
0043147 (Phosphotyrosine protein) phosphatases II 4-59 1.2e-09 33.6 In-house 72-126 (172) alignment 
Range on Protein: 4-59
Range on HMM: 72-126/172.0
SSQDYTVNlSFVIKPAFCGMLKLLLSHEENLPVLIHCVYGKDRTGVLVALILDCIG
.  |..|  .. . . |.  .. ||  ... |||.||..|..|||.|||. | . |
pwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllg
0045450 (Phosphotyrosine protein) phosphatases II 5-80 1e-09 34.1 In-house 205-283 (307) alignment 
Range on Protein: 5-80
Range on HMM: 205-283/307.0
SQDYTVNLSFVIKPAFCGMLKLLLSHE-ENLPVLIHCVYGKDRTGVLVALILDCIGVERETIA--MDYASSEDGLVSMR
  |..|  || .  .|. ...  |..  .. |||.||  |..|||...|. | . ..|.| .   .|. .  . | ..|
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR
0040439 (Phosphotyrosine protein) phosphatases II 6-63 3e-09 32.3 In-house 151-215 (249) alignment 
Range on Protein: 6-63
Range on HMM: 151-215/249.0
QDYTVNLSFVIKPAFCGMLKLLLSHE-ENLPVLIHCVYGKDRTGVLVALILD------CIGVERE
 |. |  || .  .|. ...  |..  .. |||.||  |..|||...|. |         ||  |
pdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdle
0040438 (Phosphotyrosine protein) phosphatases II 6-61 1.9e-08 29.4 In-house 183-237 (317) alignment 
Range on Protein: 6-61
Range on HMM: 183-237/317.0
QDYTVNLSFVIKPAFCGMLKLLLShEENLPVLIHCVYGKDRTGVLVALILDCIGVE
 |..|  |. .  .|. ...  |. ... |||.||. |..|||...|. | .  .|
pdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqle
0039614 (Phosphotyrosine protein) phosphatases II 7-57 8.1e-09 30.8 In-house 195-246 (297) alignment 
Range on Protein: 7-57
Range on HMM: 195-246/297.0
DYTVNLSFVIKPAFCGMLKLLLSHE-ENLPVLIHCVYGKDRTGVLVALILDC
|..|  |. .   |. ...  |..  .. |||.||. |..|||...|. | .
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylml
0047943 (Phosphotyrosine protein) phosphatases II 7-63 5.7e-07 24.7 In-house 178-235 (273) alignment 
Range on Protein: 7-63
Range on HMM: 178-235/273.0
DYTVNLSFVIKPAFCGMLKLLLSHE-ENLPVLIHCVYGKDRTGVLVALILDCIGVERE
|. |  |. .   |. ...  |..  .| ||..||. |. |||...|| | .  .|.|
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke
subfamily_OCA_pd Subfamily OCA 9-142 2.1e-51 164.9 In-house 151-278 (282) alignment 
Range on Protein: 9-142
Range on HMM: 151-278/282.0
TVNLSFVIKPAFCGMLKLLLSHEENLPVLIhcvygkDRTGVLVALILDCIGVERETIAmDY-ASSEDGLVSMRNEMYDDLIVNWGMA-EHSCQAKADTML
..  .. .||...|.|.|||..|||||.||      ||.|...|||||...||||||| |. ||||..|||.|||...||..|...| |.|||||.||.|
slveeykdkpvisgllrlllpeeenlpfLi......drlglktaliLdaeeveretia.dflasseiklvslrnevlkdlldndnyavelscqaktdtvl

KVLKEiDKRYGSTSQYLESIGFTLEDQESLKSILLH
|||.. ||.|||||.|||.||||||||||||||||.
kvLrk.dkkygstsiyleyigFtledqeslksilli
0042113 (Phosphotyrosine protein) phosphatases II 9-70 4.7e-10 34.8 In-house 152-219 (245) alignment 
Range on Protein: 9-70
Range on HMM: 152-219/245.0
TVNLSFVIKPAFCGMLKLLLSHEENLPVLIHCVYGKDRTGVLVALIL------DCIGVERETIAMDYA
.|  .  .   |. ...  |.  .| |||.||  |..|||...|. |         ||  | .  .. 
gvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelr
0038934 (Phosphotyrosine protein) phosphatases II 12-55 3.5e-08 28.8 In-house 94-137 (194) alignment 
Range on Protein: 12-55
Range on HMM: 94-137/194.0
LSFVIKPAFCGMLKLLLSHEENLPVLIHCVYGKDRTGVLVALIL
 |. |   |. ...  |.  ..  |..||..|. |||.|||  |
PsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL
0043336 (Phosphotyrosine protein) phosphatases II 13-66 1e-08 30.5 In-house 191-249 (278) alignment 
Range on Protein: 13-66
Range on HMM: 191-249/278.0
SFVIKPAFCGMLKLLLShEENLPVLIHCVYGKDRTGVLVALILD------CIGVERETIA
|. .   |. ...  |.  .| |||.||. |..|||...|| |         ||  | . 
slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeav
0051429 (Phosphotyrosine protein) phosphatases II 16-141 3.2e-27 91.3 In-house 136-272 (272) alignment 
Range on Protein: 16-141
Range on HMM: 136-272/272.0
IKPAFCGMLKLLLSheeNLPVLIHCVYGKDRTGVLVALILDCIGVERETIAMDYASSEDGLVSMRNEMYDDLI--------------VNWGMAEHSCQAK
 . |.. .|.|||.   . |||.||  ||||||..|||.|   ||..|||. ||. .. .|   ..|. .                 . . ...   ...
pqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvr

ADTMLKVLKEIDKRYGSTSQYLESIGFTLEDQESLKSILL
|...| .|..||..|||. .||...|.. |..| |...||
aeyllaaldaideeyGsvegYLrdlglseeelerLrellL
Y_phosphatase3 Tyrosine phosphatase family 17-72 1.2e-17 59.4 Pfam-A 110-163 (164) alignment 
Range on Protein: 17-72
Range on HMM: 110-163/164.0
KPAFCGMLKLLLSHEeNlPVLIHCVYGKDRTGVLVALILDCIGVERETIAMDYASS
|.|.  .|..|...| . |||.||  |||||||..||.|. .||..|||| ||. .
kkayrkvlealaeee.g.pvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt
0044763 (Phosphotyrosine protein) phosphatases II 17-55 4.1e-08 28.6 In-house 95-132 (178) alignment 
Range on Protein: 17-55
Range on HMM: 95-132/178.0
KPAFCGMLKLLLShEENLPVLIHCVYGKDRTGVLVALIL
 ..|. ... .|. |.. |||.|| .|..|.|.|||. |
flefvefieeald.ekggpvlVHCsaGvgRsgtlvaayl
0051082 (Phosphotyrosine protein) phosphatases II 18-84 6.9e-13 43.9 In-house 78-143 (151) alignment 
Range on Protein: 18-84
Range on HMM: 78-143/151.0
PAFCGMLKLLLShEENLPVLIHCVYGKDRTGVLVALILDCIGVERETIAMDYASSEDGLVSMRNEMY
.|.  .|.|||.  .| |||.||  ||.|||.||||.| . ||  |..  .| ..  |.|   ....
davleflellld.kkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqfl
0049772 (Phosphotyrosine protein) phosphatases II 18-72 3.5e-11 38.9 In-house 197-253 (314) alignment 
Range on Protein: 18-72
Range on HMM: 197-253/314.0
PAFCGMLKLLLSHEENLPVLIHCVYGKDRTG--VLVALILDCIGVERETIAMDYASS
  |  .|......... |||.||  ||.|||  |..|... . ||  |..  |. . 
edfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlk
0036282 (Phosphotyrosine protein) phosphatases II 18-60 2.1e-09 32.8 In-house 89-131 (174) alignment 
Range on Protein: 18-60
Range on HMM: 89-131/174.0
PAFCGMLKLLLSHEENLPVLIHCVYGKDRTGVLVALILDCIGV
  |.  ..  ||. .. |||.||  |..|||.|||. | . | 
lefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgl
0049260 (Phosphotyrosine protein) phosphatases II 20-59 1.6e-08 29.9 In-house 77-115 (152) alignment 
Range on Protein: 20-59
Range on HMM: 77-115/152.0
FCGMLKLLlSHEENLPVLIHCVYGKDRTGVLVALILDCIG
.. ... |  .... |||.||..|..|||.|||. | . |
lllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylmllg
0050432 (Phosphotyrosine protein) phosphatases II 20-70 3e-07 25.5 In-house 219-268 (308) alignment 
Range on Protein: 20-70
Range on HMM: 219-268/308.0
FCGMLKLLLSHEENLPVLIHCVYGKDRTGVLVALILDCIGVEREtIAMDYA
.  .|.|. .. .. |...||  |  |||...|| | .  .|.|   .|. 
lldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvf
0041856 (Phosphotyrosine protein) phosphatases II 22-55 7.9e-08 27.6 In-house 100-131 (182) alignment 
Range on Protein: 22-55
Range on HMM: 100-131/182.0
GMLKLLLSheENLPVLIHCVYGKDRTGVLVALIL
 ...  |.  |. |||.|| .|..|||.|||. |
dfieevle..eggpvlVHCsaGvgRtgtlvaayl
0048179 (Phosphotyrosine protein) phosphatases II 23-55 3.7e-08 28.7 In-house 72-105 (144) alignment 
Range on Protein: 23-55
Range on HMM: 72-105/144.0
MLKLLLSH-EENLPVLIHCVYGKDRTGVLVALIL
.|... .. ||. |||.|| .|..|||.|||. |
flefieealeeggpvlVHCsaGvgRtgtlvaayl
0045098 (Phosphotyrosine protein) phosphatases II 23-60 3.8e-08 28.5 In-house 184-233 (278) alignment 
Range on Protein: 23-60
Range on HMM: 184-233/278.0
MLKLLLS------------HEENLPVLIHCVYGKDRTGVLVALILDCIGV
...  |.            .... |||.|| .|..|||.|||. | .  .
firealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell
0046846 (Phosphotyrosine protein) phosphatases II 23-58 1.7e-07 26.7 In-house 101-134 (176) alignment 
Range on Protein: 23-58
Range on HMM: 101-134/176.0
MLKLLLSheENLPVLIHCVYGKDRTGVLVALILDCI
...  |.  |. |||.||. |. |||.|||. | . 
firealk..eggpvlVHCsaGigRtgtlvaayllel
Y_phosphatase2 Tyrosine phosphatase family 23-54 2.2e-07 22.8 Pfam-A 82-112 (165) alignment 
Range on Protein: 23-54
Range on HMM: 82-112/165.0
MLKLLLShEENLPVLIHCVYGKDRTGVLVALI
.|||||  .|| |||.||  || |||.... .
alkllln.kenypvllhckrGkhrtglvigcl
0048076 (Phosphotyrosine protein) phosphatases II 24-55 2.7e-08 29.2 In-house 71-103 (145) alignment 
Range on Protein: 24-55
Range on HMM: 71-103/145.0
LKLLLS-HEENLPVLIHCVYGKDRTGVLVALIL
|... . ..|. |||.||  |..|||.|||. |
lefieealkeggpvlVHCsaGvgRtgtlvaayl
0037934 (Phosphotyrosine protein) phosphatases II 24-59 5.3e-08 28.2 In-house 162-206 (243) alignment 
Range on Protein: 24-59
Range on HMM: 162-206/243.0
LKLLLSH-------EENLPVLIHCVYGKDRTGVLVALILDCI--G
..  ..         .. |||.||. |..|||.|.|. | .   |
vrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg
PTPc_DSPc_SM00012 27-83 9e-08 27.6 In-house 32-89 (105) alignment 
Range on Protein: 27-83
Range on HMM: 32-89/105.0
LLSHEE-NLPVLIHCVYGKDRTGVLVALILDCIGVERETIAMDYASSEDGLVSMRNEM
  ...| . ||..||  | .|||..||| . .  .|.||  .|       | ..|. |
nknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgm
IpgD Enterobacterial virulence protein IpgD 29-114 5.1e-06 11.2 Pfam-A 449-532 (559) alignment 
Range on Protein: 29-114
Range on HMM: 449-532/559.0
SHEENLPVLIHCVYGKDRTGVLVALILDCIGVERETIAMDYASSEdgLVSMRNEMYDDLIVNWGMAEHSCQAKADTMLKVLKEIDK
..| .      |  ||||||.  | |   |    ||  .   .|   | |  . ... ...| |  | |      .  ||.|..  
ayeidavpawncksGkdrtGmqdaeikreiiskhetgqlsalnsk..ldseekklfskvllnsGnmeisemntGvaGnkvmkklsl
Y_phosphatase3C Tyrosine phosphatase family C-terminal region 100-141 5.6e-12 35.1 Pfam-A 26-68 (68) alignment 
Range on Protein: 100-141
Range on HMM: 26-68/68.0
AKADTMLKVLKEIDKRYGSTSQYL-ESIGFTLEDQESLKSILL
......  .|..||.||||  .|| | .|.. ||.| |.. ||
vreeyleaaldtideryGsvegYLeeaLGlseedierLRerlL