Gene Auxilin-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP040_AA protein Get Run
AqueP040_AA_392-557 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Pkinase_Tyr Protein tyrosine kinase 41-310 1e-33 106.4 Pfam-A 1-259 (259) alignment
Range on Protein: 41-310
Range on HMM: 1-259/259.0
LKVKKVIAEGGYGFVFVAQDT----STGIDYALKRQ--IVASENIKAIKQEITFLTQLsGHPHIINFIGAASSKDPaggsaeFLIVTELITGGELVDIVN
|...| ..|| .| |. .. .    .. .. |.|       .|. ... .|......|  |..|....|. ....|      .|||||...||.| . ..
lelgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvctkeep......llivteyvegGdLlkfLr

TR---PLSPRQVLRVFYETCQAIAHMHSQTppIIHRDIKvgVENLLLTDKGSVKLCDFGSATTQrltpdhswsaTQRGLTEDEIQANTTPMYRAPEMIDL
..   .|. ...|.. .. ........|..  ..|||.     | ||.... ||..||| | .           ...  .... .|..   . |||... 
kkekekltledllsfalqiAkGmeyLeskk..lvHrdLa..arNvLleenkvvkisDfGLardi..........ekddyykkkekaklpvkWmapEslke

YSnypINEKGDIWALGCLLYKLCF-QEHPFEDSAKLR---ILNANYHIPPGDNVYKEFHNIIRSCLVVDPTKRPSVDSIVAQL
 .   ...| |.|. | ||. ..   |.|...  . .    |.......  .|. .|.......|.  .|.|||. ...| .|
kk...ftsksDvWsfGvllwEiftlgespypglsneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelvekl

Pkinase Protein kinase domain 42-309 1.4e-49 158.6 Pfam-A 2-257 (260) alignment
Range on Protein: 42-309
Range on HMM: 2-257/260.0
KVKKVIAEGGYGFVFVAQDTSTGIDYALKRQIVASENIKAIKQ---EITFLTQLsGHPHIINFIGAASSkdpaggSAEFLIVTELITGGELVDIVN-TRP
.... . .|..| |. |.. .||  .|.|.    .|. |. |.   |.  |..|  ||.|......  .      . |...|.|.. ||.| |...  ..
elleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee......kdelylvleyveggdlfdllkkkgk

LSPRQVLRVFYETCQAIAHMHSQtpPIIHRDIKVgvENLLLTDKGSVKLCDFGSATTQrltpdhswsatqRGLTEDEIQANTTPMYRAPEMIDlySNYPI
|| ... .............||.   |||||.|   ||.||..||..|..|||.| .                 |.  .   |. |.|||..   ..  .
lseeeikkialqilegleylHsn..giiHrDLKp..eNiLldekgelkiaDFGlakkl............eksseklttlvgtreYmAPEvll..kakey

NEKGDIWALGCLLYKLCFQEHPFEDS---AKLRILNANYHIPPGDNVY------KEFHNIIRSCLVVDPTKRPSVDSIVAQ
 .| |.|.||..||.|.... ||...    .|...... . .   . .      .|. ..|...|  ||.||.....|. .
tkkvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeeilkh

subfamily_Auxilin_pd Subfamily Auxilin 396-558 4.2e-71 231.0 In-house 5-163 (166) alignment
Range on Protein: 396-558
Range on HMM: 5-163/166.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNV
 ....||.|.||||.|||.|.|. .....|....|...||..||..|||.|||...|.|..||..||...||.|..|.||||||.||.|.|||..|.|||
akndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknv

LVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGqgmdISPSDRRYLNYMMAL
.|.|||||...|..||...|.|.|.|..|.||.|||...|||.|    .|||..|||.|...|
vvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig....lspsekryleyladl

0049772 (Phosphotyrosine protein) phosphatases II 396-536 1.6e-12 43.3 In-house 49-255 (314) alignment
Range on Protein: 396-536
Range on HMM: 49-255/314.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLS-----------------------------------------------
|. ..||  . .|  . ..|..  .    . .. . ...   .|... |....                                               
knryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

-------------------GEQYDTDQLSGQVVDY---EWPNRAMPPLESLVELCRQLDSWlraDFKNVLVIHCKDGVHPSGI-LVVSYLLFLRALpSPS
                   .|.|| . ...... |    .|    |.|| . |... ....   | ......|||.|.. .|  .|. ||. |. . |. 
lildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sle

SALRLFTARRL
 ||. . ..| 
ealedvrlkRp

subfamily_Tensin_pd Subfamily Tensin 397-558 2.2e-41 134.4 In-house 8-170 (189) alignment
Range on Protein: 397-558
Range on HMM: 8-170/189.0
QKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVL
.   |.||.|.||...|.| |       . ||.|.. |.  | ..|||||||  .|| ..|. .|.|. ||.   |.|| |  .|..|||||.|| .||.
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQG-MDISPSDRRYLNYMMAL
|.||| |    |..| .|. . .   | ..||  |. .|. . .   .. || |||..|. .|
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsgl

PTEN_1 397-555 1.5e-24 81.9 In-house 17-188 (196) alignment
Range on Protein: 397-555
Range on HMM: 17-188/196.0
QKSTDITYVTSRILVMSYPFEEG------GVGRPNVLKEVSAYLEGTHPSQ-YLVFNLSGEQ------YDTDQ---LSGQVVDYEWPNRAMPPLESLVEL
 . .|.||.||||..|.... ..      .    . ||.|.|.|.  ...  .||.||| |       || ..      .. .....    |.|..| . 
telldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdi

CRQLDSWLRADF-KNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRLPEGQGmdiSPSDRRYLNYM
|.....||..|  .|| ..||| |.  || .| .||....   ..  ||.|. ..| | .     ||| .|.|.| 
cksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn...spsqerlleyf

0041856 (Phosphotyrosine protein) phosphatases II 398-557 8.7e-16 53.5 In-house 15-168 (182) alignment
Range on Protein: 398-557
Range on HMM: 15-168/182.0
KSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQY-LVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSwlradFK
 | |..|.. .....|.|. .  .   . |..| ..|.  .  .. .. ||..|.|. . |     |.... ||    |.|..|......  .      .
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eg

NVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRlpegQGMDISPSDRRYLNYMMA
.. ..||. ||. .| ||. ||.  .   |. .|..|.  ||     || |.|.  ..| ... 
gpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR....pgmvitpnqyfflqlall

0044763 (Phosphotyrosine protein) phosphatases II 398-554 2e-12 42.6 In-house 19-165 (178) alignment
Range on Protein: 398-554
Range on HMM: 19-165/178.0
KSTDITYVTSRILVMSYPFeeggvgrpnvlKEVSAYLEGTHPSqyLVFNLSG---------EQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSW
  ....... .....|.|             .  ..|   . .  .. ||..          .|. .. . |.. . .|    |. || . |... ....
dyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieea

LR-ADfKNVLViHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARRlpegQgMDISPSDRRYLNY
|   . ..||| ||. ||. || ||. ||.  . | |. .|..|. .||      . ..|...|.| .
ldekg.gpvlV.HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR....p.ivpnpgqlrqLye

subfamily_PTEN_pd Subfamily PTEN 399-558 7.7e-37 122.0 In-house 19-178 (184) alignment
Range on Protein: 399-558
Range on HMM: 19-178/184.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNL-SGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
  |..|.|..|..|.|| |.      | |..|  .|| .|  .| ..|| |...||.....|.|  |.  .   |||| | |.......|| .| ||| |
dLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvv

IHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDIsPSDRRYLNYMMAL
.||| |   .|.|.|.|||  . |.....||.||.. |  ...|. | || |||..|. .|
vHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvti.PsqrRYveYyekl

0046846 (Phosphotyrosine protein) phosphatases II 399-556 2.7e-14 48.8 In-house 9-169 (176) alignment
Range on Protein: 399-556
Range on HMM: 9-169/176.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGthpSQYLVFNLSGEQ-----------YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSW
  |..|.. .....|.|    |  . .. . .  ..|      ..|.||  |.            .  .|. |.  . ||    |.|| | ||.......
dldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirea

LRADfkNVLVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPegqGMDISPSDRRYLNYMM
|...  .. ..||. |.  .| ||. ||| |.   |.  ||.|. ..| .   |.  .|. .|.| ...
lkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl...gavqtpeQyrflyefe

subfamily_VSP_pd Subfamily VSP 400-557 2.1e-27 90.5 In-house 34-196 (212) alignment
Range on Protein: 400-557
Range on HMM: 34-196/212.0
TDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGE-QYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVI
 |.|||| ||. ||.|         | ..||. .|.  |. .| |.||  | .||   .  .|.     .  .| || |. .....  || .| ||||.|
ldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlai

HCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDI----SPSDRRYLNYMMA
||| |   .| .| ..||   .. .   .|  |. ||  ...|       .||..||..|.  
hckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq

0039614 (Phosphotyrosine protein) phosphatases II 400-556 8.6e-14 47.1 In-house 83-285 (297) alignment
Range on Protein: 400-556
Range on HMM: 83-285/297.0
TDITYV-----------TSRILVMSYPFEEggvgrpnvlkevS---------------------------------------------AYLEGTHPSQYL
 | .|.           | .......| .|            .                                              .|. .| . | 
ldsdYinAsyvdgydlltrkfIatqgPlpe............tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgyt

VFNLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARRlp
|..|. . ..      ..  . ||    || ||.| |........|...  ... ..||..||. .| ... ||..     .  ... .|.. .  .|  
vrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR..

egQGMDISPSDRRYLNYMM
   |.  .||  |.| ...
..pgavqtpsqyrflydal

0051082 (Phosphotyrosine protein) phosphatases II 400-542 3.6e-12 41.6 In-house 6-134 (151) alignment
Range on Protein: 400-542
Range on HMM: 6-134/151.0
TDITYVTSRILVMSYPFEeggvgrpnvlkEVSAYLegTHPSQYLVFNLSGEQ---YDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFK
....|||........| .           .. ..|   .   . ..|| .|.   |... |     .|... ...   |.|. . . .... ..|... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVLVIHCKDGVHPSGILVVSYLLFLRalPSPSSALRLFTARRLpegqgM
.....||. |.. .|.||. ||. |.   |. .||. . ..|      .
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.....g

0036282 (Phosphotyrosine protein) phosphatases II 401-554 9.1e-22 73.0 In-house 11-164 (174) alignment
Range on Protein: 401-554
Range on HMM: 11-164/174.0
DITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIH
|..|.|.|......|..     . . .. |  .||  ..  |...|.  |  .|  .|  |.... || . .|.|. | |........|  | ......|
dlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPeGQGMDISPSDRRYLNY
|. ||. .|.||. ||.  . |.|.  ||.|. ..||    || ..|| .|.| |
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq.rpgmvqtpsQyrflyy

0043147 (Phosphotyrosine protein) phosphatases II 401-553 2.8e-14 48.7 In-house 14-154 (172) alignment
Range on Protein: 401-553
Range on HMM: 14-154/172.0
DITYVTSRILVMSYPfeeggvgRPNVLKEVSAYLEGTHPSQylVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
|..|.. |.... .|        .| | .. ..|   . .   ..|| ...||...|.    |.  . ||    |.|| | |.....|..|  . ... .
dlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvl

IHCKDGVHPSGILVVSYLLFlRALpSPSSALRLFTARRlpegQGMDISPSDRRYLN
.||. ||  .| ||. ||.  . | |.  |..|. ..|     |.  .|| .|.| 
VHCsaGvgRtgtlvaaylml.lgl.sleeavalvrekR....pgavqnpsqyrfly

0037934 (Phosphotyrosine protein) phosphatases II 401-556 3.1e-13 45.3 In-house 38-238 (243) alignment
Range on Protein: 401-556
Range on HMM: 38-238/243.0
DITYVTSRILVMSYPFEEGGVG----RPNVLKEVS---------------------------------AYLEGTHPSQYLVFNLSGEQYD---TDQLSGQ
. .||| |. ....| .|          . |.|                                    .|. .| ..| |..|. | .|     .|  .
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

VVDYEWPNRAMPP-LESLVELCRQLDSWLRA-------DFKNVLVIHCKDGVHPSGILVVSYLLFLR-AlPSPSSALRLFTARRLPegqGMDISPSDRRY
.  . ||   .|.  |.|....... .....       | ......||. ||. .| |.. ||. |.    .. .|..|. ..|      .  .|| .|.
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpg...kavqtpsqyrf

LNYMM
| ...
lyeal

0038934 (Phosphotyrosine protein) phosphatases II 404-546 1.6e-17 59.2 In-house 15-157 (194) alignment
Range on Protein: 404-546
Range on HMM: 15-157/194.0
YVTSRILVMSYPFEEGGVGRP-----NVLKEVSAYLEGTHPSQYLVFNLS--GEQYDTDQLSG---QVVDYEWPNR-AMPPLESLVELCRQLDSWLRADF
..| |......| ..    .      . .. .  ||.  .   .|| .|.  .  ||.. . .   ..... .|.. . |.|| | . .. .| .|..| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVLVIHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARRlpegqgmdisP
..| ..||| |.  .|.||..||.  . . |.  |..||. .|          |
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR..........p

0043336 (Phosphotyrosine protein) phosphatases II 404-556 1e-11 40.3 In-house 75-273 (278) alignment
Range on Protein: 404-556
Range on HMM: 75-273/278.0
YV----------TSRILVMSYPFEEggvgrpnvlkevS----------------------------------------------AYLEGTHPSQYLVFNL
|.          . .......| .|            .                                               .|. .| . | |..|
YinAsyvdgynvprkfiatqgPlpe............tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtl

SGE--QYDTDQLSGQVVDYEWPNRAMP-PLESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARRlpegQ
  .  ...  .   ..  . ||    | .|..|..........|. | ......||..||. .| ... |||.     .  ... .|.. .  .|     
evtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR....p

GMDISPSDRRYLNYMM
|.  .||  |.| ...
gavqtpsqyrflyeal

0046845 (Phosphotyrosine protein) phosphatases II 406-556 1.5e-10 36.4 In-house 76-270 (284) alignment
Range on Protein: 406-556
Range on HMM: 76-270/284.0
TSRILVMSYPFEE-------------------------GG-----VGRPNVlKEVSAY-------LEGTHPSQYLVFNLSGEQYDTDQLSGQVVDY---E
. .......| ..                          |       .|.  .||  |       |. .. . | |..|. . ..... | .|  .   .
kkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyts

WPNRAMPP-LESLVELCRQLDSWLRA-DFKNVLVIHCKDGVHPSGILVVSYLLFLRA-------LPSPSSALRLFTARRlpegQGMDISPSDRRYLNYMM
||..  || .|.|.|..|.....|.. . ... |.||..||  .| ... .||. .         ... .|.. .  .|     ||  ...  |.. ...
wpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR....pgmvqtleqyrfvyeal





0042113 (Phosphotyrosine protein) phosphatases II 433-556 6e-13 44.2 In-house 113-239 (245) alignment
Range on Protein: 433-556
Range on HMM: 113-239/245.0
YLEGTHPSQYLVFNLSGE--QYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPS
.|. .| . | |..|. .  ..|  .   ..  . ||   .|. ||.|..... ....|..| ......||..||. .| ... ||..     .   |. 
llseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsle

SALRLFTARRlpegQGMDISPSDRRYLNYMM
.|.. .  .|     |.  .||  |.| ...
eavkelrsqR....pgavqtpsqyrflyeal

0045450 (Phosphotyrosine protein) phosphatases II 433-555 6.8e-11 37.9 In-house 169-299 (307) alignment
Range on Protein: 433-555
Range on HMM: 169-299/307.0
YLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEW---PNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL------
.|. .| . | |..|  . .| .. | .|  . .   |.   || .|.|..........|...  ... ..||..||  .| ... ||.  .        
llseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtll

-PSPSSALRLFTARRlpegQGMDISPSDRRYLNYM
 ... .|..|. ..|     |.  .|.  |.| ..
dvdlleavkllreqR....pgavqnpeqyrflyea

0045098 (Phosphotyrosine protein) phosphatases II 435-535 3.9e-11 38.3 In-house 132-250 (278) alignment
Range on Protein: 435-535
Range on HMM: 132-250/278.0
EGTHPSQYLVFNLSGEQYDTDQLSGQVVDY-EWPNRAMPPLE---SLVELCRQLDSWLR------------ADFKNVLVIHCKDGVHPSGILVVSYLLFL
.  .   .|| ||. |..|  ..  ....|  ||    |.|.   |. ||.......|.             | ... ..||. ||. .| ||. ||.  
ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle

R--ALPSPSSALRLFTARR
.     .. .|.. .  .|
lleggvdlleavkelrsqR

0040439 (Phosphotyrosine protein) phosphatases II 437-553 6.8e-10 34.4 In-house 119-239 (249) alignment
Range on Protein: 437-553
Range on HMM: 119-239/249.0
THPSQYLVFNLSGEQ-YDTDQLSGQVVDY-EWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSAL
.. . | |..|  .  || . .  ... |  ||    |  .|.|..........|...  ......||..||. .|.... ||..     .   .. .|.
evkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeav

RLFTARRlpegQGMDISPSDRRYLN
.|.  .|     |.  .|.  |.| 
kllrsqR....pgavqnpeqyrfly

0049260 (Phosphotyrosine protein) phosphatases II 438-553 4.9e-11 38.0 In-house 33-143 (152) alignment
Range on Protein: 438-553
Range on HMM: 33-143/152.0
HPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLFlrALPSPSSALRLFTARRl
. . ... .   |  ..      |.  . ||    |.|. |.. . ... .|. | ... ..||. ||  .| ||. ||.      |.  |..|. ..| 
gittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvsleeavalvrekR.

pegQGMDISPSDRRYLN
    |. ..|. .|.| 
...pgavpnpgqlrfly

0051299 (Phosphotyrosine protein) phosphatases II 439-531 6.8e-09 31.1 In-house 159-261 (288) alignment
Range on Protein: 439-531
Range on HMM: 159-261/288.0
PSQYLVFNLSGE------QYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLFL----RALPSPSSA
 . | |..|  .      . .. .   .   . ||.  .|. .|.|....|.....|. . ... |.||..||  .| ... .||.     .  ... .|
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

LRLF
.. .
vkrl

0047943 (Phosphotyrosine protein) phosphatases II 441-556 2.2e-09 32.6 In-house 149-268 (273) alignment
Range on Protein: 441-556
Range on HMM: 149-268/273.0
QYLVFNLSGE--QYDTDQLSGQVVDYEWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFT
 | |..|  .  ...      ..  ..||.   |  ||||.|........|.|.  ... |.||..||  .| ... .||.     .  ... .|..|. 
dytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

ARRlpegQGMDISPSDRRYLNYMM
 .|     || ..|. .|.| ...
sqR....pgmvqtpeqyrflyeal

0048076 (Phosphotyrosine protein) phosphatases II 442-554 1.8e-12 42.6 In-house 31-137 (145) alignment
Range on Protein: 442-554
Range on HMM: 31-137/145.0
YLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRlpegQ
..|.||. |...  .|  |.. . || .  |.| | | |........|...  .. ..||. ||. .| ||. ||..|.   |. .||.|. ..|     
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllg.vsleealelvrsqr....p

GMDISPSDRRYLNY
|. ..|. .|.| .
gavpnpgqlrflye

0048179 (Phosphotyrosine protein) phosphatases II 442-549 1.1e-11 40.2 In-house 31-134 (144) alignment
Range on Protein: 442-549
Range on HMM: 31-134/144.0
YLVFNLSGEQYDTDQLSG--QVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRLpe
..|.||. | . ..      |.. . ||..  |.| | | |... ....|. .  .. ..||. ||. .| ||. ||....   |. .||.|. .||   
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklg.lsleealalvrsrrp..

gqGMDISPSDR
  |. ..|. .
..gavpnpgql

0040438 (Phosphotyrosine protein) phosphatases II 443-556 1.3e-09 33.3 In-house 159-272 (317) alignment
Range on Protein: 443-556
Range on HMM: 159-272/317.0
LVFNLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLL-----FLRaLPSPSSALRLFTARRl
... ... . ..     .     ||    || ...|..........|. | ......||..||. .| ... ||.       .  ... .|.. . ..| 
rtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.

pegQGMDISPSDRRYLNYMM
    |.  .|.  |.| ...
...pgavqtpeqyrflydal

0036941 (Phosphotyrosine protein) phosphatases II 460-552 9.1e-08 27.2 In-house 172-269 (297) alignment
Range on Protein: 460-552
Range on HMM: 172-269/297.0
QVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL-------PSPSSALRLFTARRlpegQGMDISPSDRR
.     ||   .|.  .||..........|..   ... ..||..||. || ... .|.. .         ... .|.. .  .|     |.  ...  |
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqR....pgavqtleqyr

YL
.|
fl

PTPc_DSPc_SM00012 464-519 2.4e-06 23.1 In-house 8-65 (105) alignment
Range on Protein: 464-519
Range on HMM: 8-65/105.0
YEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLR
..||.  .|   .|..||.|..... ..   .. .|.||..||  .|..|. ..|  .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq

0050432 (Phosphotyrosine protein) phosphatases II 464-517 2.4e-06 22.6 In-house 205-256 (308) alignment
Range on Protein: 464-517
Range on HMM: 205-256/308.0
YEWPNRAMPP-LESLVELCRQLDSWLradFKNVLVIHCKDGVHPSGILVVSYLLF
  ||.   || .|.|..........|    ... |.||..||  .| ... .||.
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 567-709 4.1e-19 60.1 Pfam-A 2-133 (134) alignment
Range on Protein: 567-709
Range on HMM: 2-133/134.0
HPHSFKLTGLNLTSVPIYnEARNGCKPFVEVFVDGERVHtsCNKENMDKLKEYTTKDGQISIPLNTTVYGNLLIIVHHIKSVpltkraemGMSAVKMFKF
.| ...|... | ..| . . |.||||.|.|.   . |    ....  . .|. .|.  . .| . .|.|  |. ..| .|          ... |.|..
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvf..kelasykdsterraktfivkepnrlpveGDvlveflhkdsk........lpkkekifrv

QIHTGFLSTKMTSLTLEKNELDGSAVKKTDRFPSSFKVLLNFS
...| |.... . |||.|||||.   .| ..|.. ||| | |.
wFNTsFieknqnvltlpkneLDkalkdkdkkfsknfkvelvfe

DnaJ DnaJ domain 1234-1281 1.6e-08 23.4 Pfam-A 13-59 (64) alignment
Range on Protein: 1234-1281
Range on HMM: 13-59/64.0
EADQVSKYFRKACLSVHPDKVDESNaNLARAIFDELNDAYELFEQSGA
 .... | .|| .| .|||| ....   |   | |.|.|||  ...  
sdeeIkkaYrklalkyHPDknkdde.eeaeekfkeineAyevLsdpek