Gene PTEN in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP041_AA protein Get Run
AqueP041_AA_5-190 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_VSP_pd Subfamily VSP 5-189 1.3e-63 208.7 In-house 15-205 (212) alignment 
Range on Protein: 5-189
Range on HMM: 15-205/212.0
KFRHLVSKRKRRFIADGFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFH-KVTVYPFDDHNPPPFELIQP
  |.|||. |||.  ||||||.|..   |.|| |||   . .||| .|.| |..|| ..|||||.|||||| ||.| |. .|.    |||| | .| .  
aarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellv

FCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNA-----KGVTIPSQRRYVQYYGHLIRNNLQYS
|...|  ||..|..|| .|||| |||||| ..|..||.  .|.| |..|...|| ||...     .||  |||.|||.|. ...    .  
ftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrkl
subfamily_PTEN_pd Subfamily PTEN 6-185 3.6e-85 279.6 In-house 2-182 (184) alignment 
Range on Protein: 6-185
Range on HMM: 2-182/184.0
FRHLVSKRKRRFIADGFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFH-KVTVYPFDDHNPPPFELIQPF
.|..|||.|.||  ||.|||...|..||.|||.|.||||..|||...||.........||||.|||.||| || |||. .|.|||||||||||.||....
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNAKGVTIPSQRRYVQYYGHLIRNN
.||.. ||.||..||.|.|||||||||||.|..|||. .|... ..||... ||||.|.||||||||||||.|| .|....
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
0039614 (Phosphotyrosine protein) phosphatases II 6-179 1.1e-30 102.6 In-house 51-285 (297) alignment 
Range on Protein: 6-179
Range on HMM: 51-285/297.0
FRHLVSKRKRRFI--------------ADGFDLDMTFI-----------KPNIVAMGFPSEKL-----EGVYRNKMSDVQ--------------------
... ..| |.|..               ||.|||...|           .....|...|...      . |.... . .                     
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeg

--------RYFDTHYTDHYKVYNLCSERfYDPKKFHKVTVY-PFDDHNPP-PFELIQPFCEDVDGWLKED-NRNVAVIHCKAGKGRTGVMICSYLLH---
        .. .... |.|.|..|. .. ... .....  | .. ||..|  .||.. |.| |. .|.|. . .. ..||.||.||||..|. ||..   
gtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql

-DRLFDTVKDALQFYGEARtqnAKGVTIPSQRRYVQYYG
  .   .|..|.... |.|    ..|..||| |..... 
ekeggvdvleavkelreqR...pgavqtpsqyrflydal
0037934 (Phosphotyrosine protein) phosphatases II 6-179 7.1e-30 99.8 In-house 5-238 (243) alignment 
Range on Protein: 6-179
Range on HMM: 5-238/243.0
FRHLVSKRKRRFI--------------ADGFDLDMTFIKPNIVAMGFPSEK---------LEGVYRNKMSDVQ---------------------------
....... |.|.                | ...... . |.. |...| ..         .. ..... . .                            
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-RYFDTHYTDHYKVYNLCSER---FYDPKKFHKVTVYPFDDHNPPP-FELIQPFCEDVDGWLKE-------DNRNVAVIHCKAGKGRTGVMICSYLLHDR
 .. .....|.|.|..|. |.    . ..  ...  .|. ||..|. .| .. |...|  ...|       |. .. ..||.||.||||..|. ||....
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

LFDTVKDALQFYGEARTQnaKGVTIPSQRRYVQYYG
|  .. .|.... | | .  |.|..|||.|..... 
lgvdleeavkllreqRpg..kavqtpsqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 6-178 5.8e-29 97.2 In-house 50-299 (307) alignment 
Range on Protein: 6-178
Range on HMM: 50-299/307.0
FRHLVSKRKRRFIA-------------------------------------DGFDLDMTFI----------------------------------KPNIV
......| |.|.                                       ||.||...||                                  . .. 
allpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekc

AMGFPSEKLEGVYRNkmsDVQRYFDTHYTDHYKVYNLCSERFYDPKKFHKVTVYPF---DDHNPPP-FELIQPFCEDVDGWLKED-NRNVAVIHCKAGKG
|. .|.|. | .|.|   .. .. .... |.|.|..|. ..    .. ..||....    ||. || || .  |.| |. .|.|. . .. ..||.||.|
aqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGVMICSYLLHDRLF-------DTVKDALQFYGEARtqnAKGVTIPSQRRYVQYY
|||..|. ||. ..|         .. .|.... | |    ..|. |.| |.....
RtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 6-178 1e-27 92.5 In-house 4-238 (245) alignment 
Range on Protein: 6-178
Range on HMM: 4-238/245.0
FRHLVSKRKRRF-------------IADGFDLDMTFI----------KPNIVAMGFPSEKLEG-----VYRNKMSDVQ----------------------
......| |.|.               ||.||| ..|          .|.. |...|...  .     ..... . .                       
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

--------RYFDTHYTDHYKVYNLCSERFYDP--KKFHKVTVYPFDDHNPPP-FELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLH---
        .. .... |.|.|..|. .. .|.  .. . .  .|..||..|.  ||.. |.| |. .|.||. .. ..||.||.||||..|. ||..   
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

-DRLFDTVKDALQFYGEARtqnAKGVTIPSQRRYVQYY
  .|  .. .|.... . |    . |..||| |.....
ekelgvsleeavkelrsqR...pgavqtpsqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 7-178 3.9e-25 84.2 In-house 39-271 (317) alignment 
Range on Protein: 7-178
Range on HMM: 39-271/317.0
RHLVSKRKRRF-------------IADGFDLDMTFI----------KPNIVAMGFPSEK-----LEGVYRNKMSDVQ-----------------------
.....| |.|.               .|.||| ..|          |....|...| ..     .. |.... . .                        
elpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetl

-------RYFDTHYTDHYKVYNLCSERF-YDPKKFHKVTVYPF-DDHNPPP-FELIQPFCEDVDGWLKeDNRNVAVIHCKAGKGRTGVMICSYLLH----
       .. .... .......|. |    ... . ..  |.. .||..|| ..|.. |.| |. .|. |. .. ..||.||.||||..|. ||..    
tygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqle

DRLFDTVKDALQFYGEARtqnAKGVTIPSQRRYVQYY
 . . .|..|.... |.|   ...|. |.| |.. ..
keggvdveeavkelreqR...pgavqtpeqyrflyda
0040439 (Phosphotyrosine protein) phosphatases II 8-178 7.2e-26 86.7 In-house 8-241 (249) alignment 
Range on Protein: 8-178
Range on HMM: 8-241/249.0
HLVSKRKRRFI---------------ADGFD--------LDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQ-----------------------------
....| |.|.                 ..|.        .|.. ||....|...| ..  . ... . . .                             
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

------RYFDTHYTDHYKVYNLCSERFYDPKKfHKVTVYPF---DDHNPP-PFELIQPFCEDVDGWLKED-NRNVAVIHCKAGKGRTGVMICSYLLHDRL
      ....... |.|.|..|. .. ||... ..|.....    ||. |  || .  |.| |. .|.|. . .. ..||.||.||||..|. ||....|
ygdftvtllsvevkddytvrtleltnlydges.rtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

-FDTVKDALQFYGEARTQNAKGVTIPSQRRYVQYY
      |... . . |.|  ..|. |.| |.....
ekelgvdleeavkllrsqRpgavqnpeqyrflyea
0044763 (Phosphotyrosine protein) phosphatases II 9-185 2.7e-23 78.0 In-house 6-173 (178) alignment 
Range on Protein: 9-185
Range on HMM: 6-173/178.0
LVSKRKRRFIADGFDLDMTFIKPNIVAMGFPSeklegvyrnkMSDVQRYFDTHYTdHykVYNLCSE--------RFYDPKKF-HKVTVYPFDDHNPPP-F
.|.  ... .  .. .....| |.. ....|.           .|.. . . . | |  . ||..|          |.|...  ..  .|..||..|. .
rvllsnleglersdyinaseilpglylgslpp..........addlellkelgit.h..ivnlteelelgflkcdpywpeeagiqylhipipDhgvpdll

ELIQPFCEDVDGWLKEDNRNVAViHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEARtqnAkGVTIPSQRRYVQYYGHLIRNN
| .. |.| .. .|.|....|.| ||.||.||.|.... ||.. . . .. .|.... |.|     .|. |.|.|.....   ....
ehflefvefieealdekggpvlV.HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelrllke
0043336 (Phosphotyrosine protein) phosphatases II 10-178 1.6e-27 92.1 In-house 44-272 (278) alignment 
Range on Protein: 10-178
Range on HMM: 44-272/278.0
VSKRKRRF-------------IADGFDLDMTFI----------KPNIVAMGFPSEKLEGVYRNKMSDVQ-------------------------------
 .| |.|.               .|.|||...|          .....|...|... .. ... . . .                               
enkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygd

---RYFDTHYTDHYKVYNLCSERFYDPKKFHK--VTVYPFDDHNPP-PFELIQPFCEDVDGWLKeDNRNVAVIHCKAGKGRTGVMICSYLLH----DRLF
   .. .... |.|.|..|. .. .|.....   .  ... ||. | ...|.. |...|. .|. |. .. ..||.||.||||..|. |||.    ....
ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekegg

DTVKDALQFYGEARtqnAKGVTIPSQRRYVQYY
 .. .|.... | |   .. |. ||| |.. ..
vdleeavkelreqR...pgavqtpsqyrflyea
PTEN_1 11-182 2.6e-46 152.9 In-house 7-192 (196) alignment 
Range on Protein: 11-182
Range on HMM: 7-192/196.0
SKRKRRFIADGFDLDMTFIKPNIVAMG-FPSEK-----LEGVYRNKMSDVQRYFDTHYTDH-YKVYNLCSERF-----YDPKK--FHKVT--VYPFDDHN
. .|.. . ....||.|.| . |.||| .||..      ||.||. ..||....|. . |. . |.||..|.      ||...   ..|.   .|..||.
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

PPPFELIQPFCEDVDGWLKEDN-RNVAVIHCKAGKGRTGVMICSYLLHDRLfDTVKDALQFYGEARTQNAKGvtIPSQRRYVQYYGHLI
.|... .. .|.... ||..|. .||...|||||.||.|.....||.. .  .|...||... |.|...|.   .|||.|...|.  | 
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaell
0041856 (Phosphotyrosine protein) phosphatases II 13-181 1.8e-31 104.6 In-house 6-169 (182) alignment 
Range on Protein: 13-181
Range on HMM: 6-169/182.0
RKRRFIADGFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYK-VYNLCsERFYDPKKFH----KVTVYPFDDHNPPPFELIQPFCED
| . ..   ...|...| .|......|. . .  ... .|.| ..... .  ... . ||. |. |.|....    ..  .|..||..|... .  |.|.
rysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfiee

VDGwlkedNRNVAVIHCKAGKGRTGVMICSYLLHDRlFDTVKDALQFYGEARtqnAKGVTIPSQRRYVQYYGHL
|       . .. ..||.||.||||.... ||.. .   .. .|.... ..|    ..|..|.| ...|.. ..
vle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR...pgmvitpnqyfflqlalle
subfamily_Tensin_pd Subfamily Tensin 15-198 4.3e-41 133.5 In-house 2-187 (189) alignment 
Range on Protein: 15-198
Range on HMM: 2-187/189.0
RRFIADGFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLcSERFYDPKKFH-KVTVYPFDDHNPPPFELIQPFCEDVDGWLK
 |.. . .|||.|.|   |.|. ||.| ||  ||... || . ..... |.| |.|| ||. || .|.. ||. . . |.  |..| .   |...| |||
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

EDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNA--KGVTIPSQRRYVQYYGHLIRNNLQYSPRTILLHAI
.| .||.|.||| ||||.||.. .|. . ..  . . ||. .   |  ..  .|.| |||||||.|.  |. .... . . ..|| .
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyv
0046846 (Phosphotyrosine protein) phosphatases II 16-184 7.3e-33 109.2 In-house 2-174 (176) alignment 
Range on Protein: 16-184
Range on HMM: 2-174/176.0
RFIADGFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDThytDHYKVYNLCSER-------FYDPKK----FHKVTVYPFDDHNPPPFELIQPF
|.  .|.|||...| .|......|  . ....|. .........    ... | ||..|.       .....      ... ..|..||..|..||.. .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CEDVDGWLKEDnrNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQnaKGVTIPSQRRYVQYYGHLIRN
.| .. .|||.  .. ..||.||.||||.... |||. . . .| .||... | |    . |. |.|.|..... .|...
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 19-183 6.7e-32 106.0 In-house 8-161 (172) alignment 
Range on Protein: 19-183
Range on HMM: 8-161/172.0
ADGFDLDMTFIKPNIVAMGFPseklegvYRNKMSDVQRYFDTHYTDHykVYNLCsERFYDPKKFH----KVTVYPFDDHNPPPFELIQPFCEDVDGWLKE
 . ..||...| ....|. .|       .|| ..|. |.. ..  .|  ..||. |..|||....    ..  .|..||..|..||.. |.| .| .| .
inasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellal

DNRNVAVIHCKAGKGRTGVMICSYLLHdrLFDTVKDALQFYGEARtqnAKGVTIPSQRRYVQYYGHLIR
.. .. ..||.||.||||.... ||..  |  .. .|.... |.|    ..|..|||.|...|. .|..
spggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfeklll
0046845 (Phosphotyrosine protein) phosphatases II 19-177 4.6e-26 87.3 In-house 65-268 (284) alignment 
Range on Protein: 19-177
Range on HMM: 65-268/284.0
ADGFDLDMTFIKPNIVAMGFPSEK-----------------------------LEGVYRNKMSDVQRY-------FDTHYTDHYKVYNLCSERFYDPKKF
 ||.|||.| ||....|. .| ..                                 |.. ...|..|        .... |.|.|..|. ..   ... 
vdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytges

HKVTVYPF---DDHNPPP-FELIQPFCEDVDGWLKE-DNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDT----VKDALQFYGEARTQNAKGVTIPSQRR
..||.. .    ||. || .| .. |...|. .|.. .. .. |.||.||.||||..|. .||...|  .    . |.|. .   |.|    |. ..| |
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr

YVQY
.| .
fvye
0036282 (Phosphotyrosine protein) phosphatases II 21-185 4.2e-42 139.1 In-house 7-172 (174) alignment 
Range on Protein: 21-185
Range on HMM: 7-172/174.0
GFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKF-HKVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNV
 ..||.. | |...|...| . .| ..... ..| .. . .. ..||..|...|. .|.... ...  .|..||..|... .. |.. |. .|.||. ..
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

AVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNAKGVTIPSQRRYVQYYGHLIRNN
 ..||.||.||||.... ||.. .|. .. |||... |.|.|. ..|..|||.|...|.. |....
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsgs
0045098 (Phosphotyrosine protein) phosphatases II 21-183 1.2e-27 92.4 In-house 4-272 (278) alignment 
Range on Protein: 21-183
Range on HMM: 4-272/278.0
GFDLDMTFIKPNIVAMGFPSEKLEGVYRNKMS--------------------------------------------------------------------
...||.. .  .....|.||| ....|.. ..                                                                    
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------DVQRYfDTHYTDHYKVYNLCSERFYDPKKFHKVTVY-PFDDHNPPPFE---LIQPFCEDVDGWLK------------
                       ..... |. .. ...|.||..|| .... . ..  | |..||..|...    .. ..| .. .||            
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

EDNRNVAVIHCKAGKGRTGVMICSYLLHDRLfDTVKDALQFYGEARTQNAK-GVTIPSQRRYVQYYGHLIR
.|. .. ..||.||.||||.... ||. ..| . . |.|. . | |.|     |....| |.. ..  ...
ldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllell
0036941 (Phosphotyrosine protein) phosphatases II 21-178 2.4e-19 65.2 In-house 73-272 (297) alignment 
Range on Protein: 21-178
Range on HMM: 73-272/297.0
GFDLDMTFIK---------------------PNIVAMG-------------FPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFyDPKKFHKVT
|.||...||                      . || .              .|.|. | .. ....   . ..... |.|....|. .   . .. ..||
gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvt

VYPF---DDHNPPP-FELIQPFCEDVDGWLKED-NRNVAVIHCKAGKGRTGVMICSYLLHDRLF----DTVKDALQFYGEARTQNAKGVTIPSQRRYVQY
.. .   .||..|. .. .  |.| |. .||.  . .. ..||.||.||.|..|. .|....|         | |... . |.| .  |. ..| |.. .
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye

Y
.
a
subfamily_Auxilin_pd Subfamily Auxilin 23-184 6.6e-40 129.5 In-house 8-166 (166) alignment 
Range on Protein: 23-184
Range on HMM: 8-166/166.0
DLDMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLcSERFYDPKKFH-KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAV
|||...|   |. | ||.|..|  |.|.. ||. . .......|.|||| |.| |...|.. .|. . .  .. |. | .   | ... |||.|..|| |
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNAkgvTIPSQRRYVQYYGHLIRN
.||| |.  ..|.....|.. ||. ....|....   |.        ||..||..| ..|...
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladllae
0051082 (Phosphotyrosine protein) phosphatases II 24-178 2.9e-25 84.0 In-house 6-147 (151) alignment 
Range on Protein: 24-178
Range on HMM: 6-147/151.0
LDMTFIKPNIVAMGFPSEklegvyrnkmsDVQRYFdtHYTDHYKVYNLCS--ERFYDPKKFHK----VTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNR
...... ... ..|.|..           |. ...  .  ... ..||.|  || |.|. ...    |. .|..|. .|...|..... ..  .| ... 
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAVIHCKAGKGRTGVMICSYLLHdrLFDTVKDALQFYGEARTqnakGVTIPSQRRYVQYY
.. ..||.|||||||.... ||..  |  .. .||..| . |.    ||..|.| ...|..
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp....gvvqpnqqflfqlf
subfamily_CDC14_pd Subfamily CDC14 25-145 2.8e-09 31.3 In-house 171-291 (328) alignment 
Range on Protein: 25-145
Range on HMM: 171-291/328.0
DMTFIKPN-IVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFHKVTVY----PFDDHNPPPFELIQPFCEDVDGWlkednRNV
|...| |. ..|.  | .| .   . ..   .....   . . .      .. || ||| .  .      | |   |. .... | | ..       .  
DfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa

AVIHCKAGKGRTGVMICSYLLHDRLF
...||||| |||| .| .||...  |
iavhCkaGLGrtGtLiacylmkhyrf
0038934 (Phosphotyrosine protein) phosphatases II 28-178 8.3e-40 131.9 In-house 15-166 (194) alignment 
Range on Protein: 28-178
Range on HMM: 15-166/194.0
FIKPNIVAMGFPSEK-----LEGVYRNKMSDVQRYFDTHYTDHYKVYNLC-SERFYDPKKFHKV----TVYPFDD-HNPPPFELIQPFCEDVDGWLKEDN
.|.....|...|...     .|..||. ..|. ||..... ....|..|. .||.|||..|.|.      .|| | ...|..|... |.. || .|.||.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

RNVAVIHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEARtqnakgvtiPSQRRYVQYY
 .| ..|||||.||||.....||.. . . ....|.... |.|         |.. ....|.
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdyl
0049260 (Phosphotyrosine protein) phosphatases II 34-182 1.9e-30 100.9 In-house 5-149 (152) alignment 
Range on Protein: 34-182
Range on HMM: 5-149/152.0
VAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKK-FHKVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTG
.||.|.    .|...| ..|. |.. ..  ... ... ..|. ..  .   ..  .|..||..|... . .|. ... .|..|. .. ..||.||.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

VMICSYLLHdrlfdTVKDALQFYGEARTQNAKGVTIPSQRRYVQYYGHLI
.... ||..        ......   |... ..|. |.|.|.....  |.
tlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekll
0048179 (Phosphotyrosine protein) phosphatases II 38-180 1.3e-25 85.2 In-house 3-142 (144) alignment 
Range on Protein: 38-180
Range on HMM: 3-142/144.0
FPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFH--KVTVYPFDDHNPPPF-ELIQPFCEDVDGWLKEDnrNVAVIHCKAGKGRTGVM
.||| |.|.|.. . .....   .  ... |.||..|. ..  ...  ..  .|..||..|.. ||.. |.| .. .|.|.  .. ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ICSYLLHdRLFDTVKDALQFYgeaRTQNAKGVTIPSQRRYVQYYGH
.. ||.. .|  ....||...   |...  .|. |.|.|....|..
vaaylmk.klglsleealalv...rsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 38-180 1.6e-25 84.9 In-house 3-140 (145) alignment 
Range on Protein: 38-180
Range on HMM: 3-140/145.0
FPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFHKVTVYPFDDHNPPPF-ELIQPFCEDVDGWLKEDnrNVAVIHCKAGKGRTGVMIC
.||| |.|.|.. . .....   .  ... |.||.||. .  ..  ..  .|..||..|.. ||.. |.| .. .|||.  .. ..||.||.||||....
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

SYLLHDRLfDTVKDALQFYGEARtqnAKGVTIPSQRRYVQYYGH
 ||.. .   .. .||... ..|    ..|. |.|.|..... .
aylmlllg.vsleealelvrsqr...pgavpnpgqlrflyefel
0049772 (Phosphotyrosine protein) phosphatases II 39-179 4e-25 84.6 In-house 155-274 (314) alignment 
Range on Protein: 39-179
Range on HMM: 155-274/314.0
PseklegvyrnkmsdvqRYFDTHYTDHYKvynlcsERFYDPKKFHKV-TVY---PFDDHNPPPFELIQPFCEDVDGWlkeDNRNVAVIHCKAGKGRTGV-
.                 . . .. ...|      |. |||..| .    |   |..|...|..| .. |.| .. .   |. .. ..||||||||||. 
g................neptaadlellk......eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtf

MICSYLLHDRLFdTVKDALQFYGEARTQNAKGVTIPSQRRYVQYYG
... ||.. . . ....||... ..|. | . ..|.....|.... 
vvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefile
0051429 (Phosphotyrosine protein) phosphatases II 39-190 7.4e-12 41.0 In-house 76-232 (272) alignment 
Range on Protein: 39-190
Range on HMM: 76-232/272.0
PSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFHKVTVYPFDDHNPPPF--ELIQPFCEDVDGwlkednRNVAVIHCKAGKGRTGVMIC
| .  .    . .  . ... ......| ...|. .. ..... ..|... . |    .   | .  . | .         .  ..||.|||.|||....
pilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvva

SYLLHDRLF-DTVKD--------ALQFYGEARTQNAKGVTIPSQRRYVQYYGHLIRNNLQYSP
 .||  ..  .|. |        ..... | | | .. |  . |..... .   . ..|. ..
llllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvr
subfamily_RNGTT_pd Subfamily RNGTT 54-161 3.7e-11 37.0 In-house 44-156 (189) alignment 
Range on Protein: 54-161
Range on HMM: 44-156/189.0
VQRYFDTHYTDHYKVYNLCS-ERFYDPKKFHK-----VTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDt
.  |..|. .    | .|   .|.|| ....|     | .      . |  | .. | . |. . |.  ..|  .||. |  ||| .|.|||.. . .. 
llsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws.

VKDALQFYGEARTQ
|..|.. . .|| .
veaavalFakaRpp
0050432 (Phosphotyrosine protein) phosphatases II 56-177 1.4e-17 59.4 In-house 152-293 (308) alignment 
Range on Protein: 56-177
Range on HMM: 152-293/308.0
RYF-------------------DTHYTDHYKVYNLCSERFYDPkKFHKVTVYPF---DDHNPPP-FELIQPFCEDVDGWLkedNRNVAVIHCKAGKGRTG
.|.                   ...  |.|.|..|. .   |. . ..||.. .    ||. || .| .  |.| |. .|   . .. |.||.|| ||||
qYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtG

VMICSYLLHDRL-FDTVKDALQFYGEARTQNAKGVTIPSQRRYVQY
..|. .||...|  .   |... .   |.| .  |. |.| ... .
tfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 57-161 4.8e-07 24.1 In-house 138-246 (274) alignment 
Range on Protein: 57-161
Range on HMM: 138-246/274.0
YFDTHYTDHYKVYNLCSERFYDPKKFHKVTVYPF-DDHNPPPFELIQPFCEDVDGWLKEDNRN--VAVIHCKAGKGRTGVMICSYLLHDRLF-DTVKDAL
  ..  ...|.| .|  .   .... .      . | . |   . .  ....|.   .|.| .   .|.|| || ||||. |   .   .|  ..| | |
vekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

QFYGEARTQ
.   . | .
kivcnlrld
0051299 (Phosphotyrosine protein) phosphatases II 58-177 2.8e-22 75.0 In-house 154-280 (288) alignment 
Range on Protein: 58-177
Range on HMM: 154-280/288.0
FDTHYTDHYKVYNLCSERFY---DPKKFHKVTVYPFD---DHNPPP-FELIQPFCEDVDGWLKeDNRNVAVIHCKAGKGRTGVMICSYLLHDRL-FDTVK
 ...  |.|.|..|. ..      ... ..||.. .    ||. |. .||.  |...|. .|. .. .. |.||.||.||||..|. .||...| .  . 
lseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggv

DALQFYGEARTQNAKGVTIPSQRRYVQY
|.|...   |.|    |. |.| |.| .
dvleavkrlreqRpgmvqtpeqyrfvye
0047943 (Phosphotyrosine protein) phosphatases II 58-177 3.4e-21 71.3 In-house 142-266 (273) alignment 
Range on Protein: 58-177
Range on HMM: 142-266/273.0
FDTHYTDHYKVYNLCSERFYDPKkFHKVTVYPFD---DHNPP-PFELIQPFCEDVDGWLKED-NRNVAVIHCKAGKGRTGVMICSYLLHDRL-FDTVKDA
 .... |.|.|..|. ..  ...  ..||.. .    ||. |  .| .  |.|.|. .|... . .. |.||.||.||||..|. .||.|.|      |.
lseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

LQFYGEARTQNAKGVTIPSQRRYVQY
|. .   |.|   .|. |.|.|.. .
leavkllrsqRpgmvqtpeqyrflye
Y_phosphatase Protein-tyrosine phosphatase 60-171 1.6e-07 26.4 Pfam-A 115-225 (235) alignment 
Range on Protein: 60-171
Range on HMM: 115-225/235.0
THYTDHYKVYNLCSERfyDPKKFHKVTVYPFDDHNPP-PFELIQPFCEDVDGWLkEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFD-TVKDALQFYGE
   . .... . ..|.  ...... . .    ||. |   . .  ....|  .  |....  |.||.|| ||||....  .| ..| .    | ||.  |
eytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivke

ARTQNAKGVTIPSQ
 |.| .. |.  .|
lRkqRpgmvqsleq
Y_phosphatase Protein-tyrosine phosphatase 60-171 1.6e-07 26.4 In-house 115-225 (235) alignment 
Range on Protein: 60-171
Range on HMM: 115-225/235.0
THYTDHYKVYNLCSERfyDPKKFHKVTVYPFDDHNPP-PFELIQPFCEDVDGWLkEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFD-TVKDALQFYGE
   . .... . ..|.  ...... . .    ||. |   . .  ....|  .  |....  |.||.|| ||||....  .| ..| .    | ||.  |
eytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivke

ARTQNAKGVTIPSQ
 |.| .. |.  .|
lRkqRpgmvqsleq
subfamily_PRL_pd Subfamily PRL 71-160 1.2e-09 32.4 In-house 40-131 (151) alignment 
Range on Protein: 71-160
Range on HMM: 40-131/151.0
LCSERFYDPKKFH----KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLfdTVKDALQFYGEART
 . |  || .|..    .|. ..||| ..|| |... . | .    ||.. ..  .|| || ||. |...  |. . .  . .||..|  | | 
rvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kyedavefirekrr
DSPc Dual specificity phosphatase, catalytic domain 72-162 3.7e-09 31.6 Pfam-A 29-117 (133) alignment 
Range on Protein: 72-162
Range on HMM: 29-117/133.0
CSE-RFYDPKKFHKVTVYPFDDHNPPPFELIQPFCEDVDgWLKEDNRNVAViHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEARTQN
... ... ....... .   |...    . ..   | ..  .......|.| ||.||  |.. .|. ||.  . . ....|..|  | | . 
vpnnnaikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlV.HCqaGisRSatliiaYlmktknl.slneAyefvkerrski
DSPc Dual specificity phosphatase, catalytic domain 72-162 3.7e-09 31.6 In-house 29-117 (133) alignment 
Range on Protein: 72-162
Range on HMM: 29-117/133.0
CSE-RFYDPKKFHKVTVYPFDDHNPPPFELIQPFCEDVDgWLKEDNRNVAViHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEARTQN
... ... ....... .   |...    . ..   | ..  .......|.| ||.||  |.. .|. ||.  . . ....|..|  | | . 
vpnnnaikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlV.HCqaGisRSatliiaYlmktknl.slneAyefvkerrski
subfamily_DSP11_pd Subfamily DSP11 73-160 3e-11 37.5 In-house 66-158 (178) alignment 
Range on Protein: 73-160
Range on HMM: 66-158/178.0
SERFYDPKKFHKVTVY----PFDDHNPPPFELIQPFCEDVDGWL--KEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTvKDALQFYGEART
 .|.|..|.... .|         |. |  ||.. |.| |. .|  ..|| ..  .||  |  ||| .|| ||..   ... .||.. . ||| 
tdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyep.edaieafeearG
0048567 (Phosphotyrosine protein) phosphatases II 75-178 2.4e-09 31.8 In-house 26-134 (157) alignment 
Range on Protein: 75-178
Range on HMM: 26-134/157.0
RFYDPKKFHK----VTVYPFDDHNPPPFELIQPFCEDVDGWLK--EDNRNVAVIHCKAGK---GRTGVMICSYLLHDRLFdtvkDALQFYGEARTQNAKG
..|... |.     | . .| |. |..  ..  |.  .. .||  | .... ..|||||    |||...|..||.    |    .. ....  |  . . 
slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf....tpeeaiaplrivrpgs

VTIPSQRRYVQYY
|  . .  .. .|
vpfrdasyllsly
PTPc_motif_SM00404 79-161 4.9e-07 24.7 In-house 44-123 (140) alignment 
Range on Protein: 79-161
Range on HMM: 44-123/140.0
PKKFHKVTVYpFDD-HNPPPFELIQPFCEDVDGWlkEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDtVKDALQFYGEARTQ
 ..|. . .   || .. . .. ..   . ..    |...   ..||.||  |.. .|. ||.. | .. ...|..|. | | .
nsgfqilqip.lddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqls.laeayefvkerRpi
subfamily_DSP19_pd Subfamily DSP19 79-159 3.1e-06 21.6 In-house 53-130 (152) alignment 
Range on Protein: 79-159
Range on HMM: 53-130/152.0
PKKFHKVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDnrNVAVIHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEAR
||.|. ...  .|. .    . ..   . ..  ...|  .. ..||.||  |.  .. .||....   ....||.   |||
pkdftylsieilDlpetdllsylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeel.sleealelvrear
subfamily_PTPMT1_pd Subfamily PTPMT1 80-162 4.8e-07 24.4 In-house 72-151 (171) alignment 
Range on Protein: 80-162
Range on HMM: 72-151/171.0
KKFHKVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRnVaVIHCKAGKGRTGVMICSYLLHDRLFDtVKDALQFYGEARTQN
   . ...   |  . | .| ..   | ..   .. .| |  .|||||.||.. .. .||.. . ..  ..||..  . | . 
lgveqlqlatvDfteapdleklekgvefiekvaskgkr.v.YvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkRkii
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 85-174 9.5e-07 23.2 In-house 182-271 (318) alignment 
Range on Protein: 85-174
Range on HMM: 182-271/318.0
VTVYPFDDHNPPPFELIQpFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRL-FDTVKDALQFYGEARTQNAKGVTIPSQRRY
.| .|  .    . .|.. .  .|. . .. .... |.|| || ||||| |    | .|.  ... | .|.  . |.|    | . .|  .
ytsWpdegvpesgaslld.lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyef
subfamily_PTPDC1_pd Subfamily PTPDC1 86-174 2e-09 32.2 In-house 86-167 (182) alignment 
Range on Protein: 86-174
Range on HMM: 86-167/182.0
TVYPFDDHNPPPFELIQPFCEDVDGWLKEDnrNVAViHCKAGKGRTGVMICSYLLHDRLFDTvKDALQFYgeaRTQNAKGVTIPSQRRY
  ....|.. .. | |      |.  |.|.  .||| || ||.|||||.|..||.. . ... ..|...    | . .| .   .| . 
ynfgwkDygvasleriLdivkvvafalqeg..kvav.hChaGlGrtGvliacylvyakrlta.ekaiklv...rskrpksiqtreqvel
PTPc_DSPc_SM00012 90-171 1.5e-11 39.8 In-house 10-95 (105) alignment 
Range on Protein: 90-171
Range on HMM: 10-95/105.0
FDDHN-PPPFELIQPFCEDVDGWLKEDN-RNVAVIHCKAGKGRTGVMICSYLLHDRLFDT--VKDALQFYGEARTQNAKGVTIPSQ
  ||. | . . |  ....|. . .. . ..  |.||.|| ||||.... ..|...| ..    | .|.  | |.| .. |.   |
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq
subfamily_DSP23_pd Subfamily DSP23 90-177 3.6e-08 28.2 In-house 59-140 (148) alignment 
Range on Protein: 90-177
Range on HMM: 59-140/148.0
FDDHNPPPFELIQPFCEDVDGwLKEDNRNVAvIHCKAGKGRTGVMICSYLLHDRLFDTvKDALqfyGEARTQNAKGVTIPSQRRYVQY
 ||. ||  | .. | . |.   .| |  |. .||  |.|||| |.  ||.. | . .  .|.    | | .    |    | . |. 
iddyhppaleqvvefvrvvee.aeekneavs.vhcllgrgrtgtmlacylvkerklaa.aeai...aevrrlrpgsvetveqeklvrd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 104-177 9.7e-06 19.8 In-house 203-277 (319) alignment 
Range on Protein: 104-177
Range on HMM: 203-277/319.0
FCEDVDG-WLKEDNRNVaVIHCKAGKGRTGVMICSYLLHDRL-FDTVKDALQFYGEARTQNAKGVTIPSQRRYVQY
. ...   . |.... . |.|| || ||||  |      .|.  ..| |  ..  . |||    |  |.| ... .
llkrirksrektqsgPi.vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiye
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 188-346 2.4e-33 106.2 Pfam-A 1-133 (134) alignment 
Range on Protein: 188-346
Range on HMM: 1-133/134.0
YSPRTILLHAIRLEGIPNF-SGGTCAPFFIVRKHKVVL-YTSKVYESIRRT-DAFAELMLTKPIPLCDDIKVEFYHNPrfgSKASYTEKMFLFWFNTFFV
| |... |..|.||||||| ..|.| |.. | ..|... .... |.. ... .  . . . ...|...|..|||.|.    || .. ||.| .||||.|.
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkd...sklpkkekifrvwFNTsFi

DWhvmqqeaqnamatnslsvswlytasHFRVVILPKNEIDKANKDKkHKQYPCNFKVHMVLS
.                             |..|||||.|||.||| .|... ||||..|..
ek.........................nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe