Gene AquePTP-Un-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP044_AA protein Get Run
AqueP044_AA_405-675 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 396-683 7.8e-50 164.4 In-house 14-250 (392) alignment
Range on Protein: 396-683
Range on HMM: 14-250/392.0
TELEHCLRYYGSLHDQYMsiPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWE
 .  |.  ... .||     |  .          ..|||| ..||  ..||.| .   |..|||.|| .|...  . |||||.||| . .. ||||||..
eknrhsalffeefhdlpg..pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfq

QRTTVIIMTTGLVERNmakcnqywpdthgygvtetygdiqvtvrkkvnhndytlttflvqhlERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRS
...| |.| | | | .                                                . .| |  . .|.||| .||   ||.. |. | .  
envttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad

RESFTMpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVPRIHGMN
  ..|   | ..|||||.||||| |  |  .   ..|.|.||. .|.|.|. |  |||||.|| |..  . |       ..| .|  .
fGqyth..pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftd

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 403-669 3.5e-47 155.6 In-house 12-293 (301) alignment
Range on Protein: 403-669
Range on HMM: 12-293/301.0
RYYGSLHDQYMSIPANMTSMNEIPSGAQ--EKNRYCDVLPNPNSRVVLFLK--FGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRT
 .  ....|| ..  .    ...    .  . ||. .. . .. |..|  |  . ... .||||..| ||. ..|..||.|||.  |..||||..|....
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekp

TVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQ--------HLERH-------VTREVIHYWYTNWPDMGVPDNPS
. |.| |.| |.  .||.||||...    .|..| ..||. .. .. |...  . |.        ..||.        ...|. .  |.||. ||  .| 
vsivmvtnlkegtkskceqywpnsea..eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

SVVDFLLETrRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 |.  . .    |.     || |||||....|.||..  .||.        .||  ..  .|. . |.|.| .||....... .| 
tvLqviddv.ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 404-669 4.9e-76 250.8 In-house 32-290 (298) alignment
Range on Protein: 404-669
Range on HMM: 32-290/298.0
YYGSLHDQYMSIPANMTSMNEIPSgAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSkAYIATQGPLPFTIADFWRMVWEQRTTVIIM
 .  |.    .|... ... . |.  ..||||.|...   |||||  . .  .|||||| |. .|.|.. |.||||.||. |..||||||.|.  ..|.|
efqrlnsvsseieeeekevarkpe.nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVm

TTGLVERNMAKCNQYWPDTHgygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRsRESFTMPG
 | |.| .  |...||||..    .||||.|.|....| .. |.. ... |.. ... .||| .  .|.||| ||| | .||.|.| . |.  .. .   
ltnleeldktkyhkywPdeg....ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnk

PAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
| .|.||||.||.| ||  |  .  ... |..||...|  .|..| |.|||..||||....  |. 
pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

0051299 (Phosphotyrosine protein) phosphatases II 406-670 2.6e-91 301.3 In-house 26-287 (288) alignment
Range on Protein: 406-670
Range on HMM: 26-287/288.0
GSLHDQYMSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTT
   ... .|. ...|    .    .||||| |.||. .|||.|    |. .||||||..|.||. . | .|||||||| |..|||||||||...||.| |
leefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmlt

GLVERNMAKCNQYWPDthgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHL----ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTM
.|||... || ||||.    | ..|||||.|| .. . ..|||..|. |..|      . .|.|.|..||||||.||||.|....||| . |....    
klvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sg

PGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
.|| |||||||.||||.|| .|. .. ||.....|||..|. .|. | ||||| .||.|....|.||.|
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 407-674 6.6e-122 400.9 In-house 6-273 (274) alignment
Range on Protein: 407-674
Range on HMM: 6-273/274.0
SLHDQYMSIPANMtSMNEIP-SGAQEKNRYCDVLPNPNSRVVLFLKFGIAN-SDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMT
.|.......|.|. ...|.  .|.|.||||...|||.||||.|  . . .. |.|||||.|.||...||||.|||||||.|.||||||.......||.|.
dlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TGLVERNMAKCNQYWPDTHGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMP-G
| | |.|..||..|.||...| ..|.|||....|.|.|..|||.........|||  .|.|.|||||.|||. .||......|..||...|||. ... .
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakla

PAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGY
|.||||||||||||.||...|..|.|.|....|||.||.|.|.||||||||..|| ..|..|..|.||. .
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrlla

subfamily_PTPRA_pd Subfamily PTPRA 408-668 2.3e-77 255.1 In-house 34-294 (330) alignment
Range on Protein: 408-668
Range on HMM: 34-294/330.0
LHDQYMSIPA-NMTSMNEIPS--GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMT
..... ..|| .. .  |. |    .||||. ..||.  |||.|  | |. .|||||| || ||. . . .||.|||.  |. |||||.|||... |.| 
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk.ekdkfiaaqGPkeetvedfwrmiweqksativml

TGLVERNMAKCNQYWPDThgyGvTETYGDIQVTVRKKVNHNDYTLTTFLVQH----LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFT
| | ||.  ||.|||||    | . |||.|.|.|....  .|||.  ||||.     ... .| |  . .| |||.||| .|  ....| . .. ..  .
telkerkeekcaqywPde...G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa

MpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
   | |||||||.|||| ||  |  .  ..  ...|| ..| ..|. |  ||||. ||.|..|.| ||
g..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 408-669 2.6e-71 235.3 In-house 24-283 (305) alignment
Range on Protein: 408-669
Range on HMM: 24-283/305.0
LHDQYMSIPANmTSMNE--IPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTT
|  || |.. .  ....    .  ..|||. .. . ...|. |  |    .||||||... ||. ..|.||..||||. |.|||||...| ....|.| |
leaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk.rkkkyivaqgPlkntvadfWrliveekvstivmlt

GLVERNMAKCNQYWPDTHGYgvTETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGP
.||| .  ||.||||.....  .. .|...|... . . .||.   . .    | . .| |..|  |.||| |||. ..|..... . ......     |
klveggkdkCrqYWpeskte..kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvp

AVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 .||||||.|||||||  || .  |.. ...|| ... ..|. | .||||.||||||| .| |. 
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 408-469 8.9e-06 19.3 In-house 24-87 (440) alignment
Range on Protein: 408-469
Range on HMM: 24-87/440.0
LHDQYMSIPANMTSMNEIPS--GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYR
 .|..  .|. ... ..| |    . |||| ..|   .|||.|    |. .|||||| .| |  
fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

0036941 (Phosphotyrosine protein) phosphatases II 409-677 1.1e-85 282.9 In-house 19-285 (297) alignment
Range on Protein: 409-677
Range on HMM: 19-285/297.0
HDQYMSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLflkfGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLV
... ... ....    .  . .||||| |.||....||.|    .  .||||||... ||. . | .|||||||| |..|||||||||..|||.| | ||
feellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelv

ERNMAKCNQYWPDThgYGVTETYGDIQVTVRKKVN--HNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAV
|... || ||||..   | . ||||..||...     ..||||.|. |....   .|.| |..||.|||.|||..|.|..||. . |. .. .. .|| .
elgrekcaqywple..egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvl

VHCSAGIGRTGVFIGADIGMRELE---ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVP
||||||.||.|.||.||. .. ||   ... .|.| .|  .|. | |.||| .||.||. .|.|. |.. ...|
VHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 409-668 1.6e-74 245.5 In-house 24-278 (288) alignment
Range on Protein: 409-668
Range on HMM: 24-278/288.0
HDQYMSIpANMTSMNEI--PSG--AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMT
...| |. |.. . ..    .    ..|||| ..||    || |      |..|||||..| |.... |.||||||||. |. |||..|.|..|. |.| 
seeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivml

TGLVERNMAKCNQYWPDTHgygVTETYGDIQVTVRKKVNHNDYTLTTFLVQhlERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFtmPGP
|.|||..  ||..||||..     . ||...||.... . .|..| ..|..   ..  .|. .| |. |||.|||..   ....|     . ..    ||
telveggktkCeeYWPdad...kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgp

AVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
 .||||||.||||.|| .|  . ..||...|||. .||..|. |  .|||. ||.|....| . 
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_CG42327_pd Subfamily CG42327 409-600 1.7e-52 173.0 In-house 8-198 (319) alignment
Range on Protein: 409-600
Range on HMM: 8-198/319.0
HDQYMSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLV
 ...  .|  ... .|.| ....|.|. .|.| |..||||  .    .. |..|...|||.     |||.| .|  . .||||.||||.. ||.  | | 
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERNMAKCNQYWPDTHGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYtNWPDMGVPDNPSSVVDFLLETRRSRESFT
|  . .| .|.|   .   |..||||.||....  .. | ..|.|....... .||. |||| .|.. .|| ......  |||.| | .|..
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslksys

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 412-671 1.3e-85 281.7 In-house 1-266 (270) alignment
Range on Protein: 412-671
Range on HMM: 1-266/270.0
YMSIPANMTSMNEIPSGAQEK--NRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVE
.. .. . || ...|. |..|  ||| |.||.|..||.|       .. |||||..||. |..|.|||..|||| |. .||||.||...| |.|||||.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

RNMAKCNQYWPDTHGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQhlERHVTREVIHYWYTNWPDMGVPDNPS------SVVDFLLETRRSRESFTMPG
..  ||..|||   .  |. ..|.|.|.. ...... | ||   ..  |.  .|...|.||..||| ||| ..       ...  | . |||....   .
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
| .||||||.||||..|  ||..| ||||. .|||.|....|.||  .||. .|| ||.| . |||.|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

0047943 (Phosphotyrosine protein) phosphatases II 413-669 1.3e-87 289.0 In-house 22-272 (273) alignment
Range on Protein: 413-669
Range on HMM: 22-272/273.0
MSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLflkfGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNM
.|.. ..|    .    ..|||| |.||. .|||.|    |  .||||||....||. . | .|||||||| |..|||||||||...||.| | |||...
lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

AKCNQYWPDTHGYgVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAG
 || ||||.. |  ...|||...||...  ...|||..|. ...|. . .|.|.|..||.|||.|||....|...|. . |. .|..  .|| |||||||
ekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
.||||.|| .|. .. ||.....||| .|. .|. | ||||| .||.||...|.||.
vgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 413-669 7.5e-55 180.8 In-house 18-266 (283) alignment
Range on Protein: 413-669
Range on HMM: 18-266/283.0
MSIPANMTSMNeIPSGAQEKNRYCDVLPNPNSRVVLFLKFGiansDYINANFIR--GYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVER
.|.|   . ..   .  ..|||. ...|  . || |  .      ||||| ||       |.| ||..|.||  |. |||.||.... | |.| | | | 
lsvpdldadia.sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

NMAKCNQYWPDThGygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHC
.  || ||||   |   .| ||.  ||.|| . .| ..   .|...    . |  . || . .| ..|      |.| | .     .||    || ||||
lrikCsqyWPkr.G...sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkgPivvhC

SAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|.|||||.|||.|   . ..    ..||  .| .||..| ..|||.||| ..|..  | |
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa

0050432 (Phosphotyrosine protein) phosphatases II 414-672 1.4e-91 302.3 In-house 53-302 (308) alignment
Range on Protein: 414-672
Range on HMM: 53-302/308.0
SIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLflkfGiANSDYINANFIRGYR-GQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNM
|.. ...         ..|||| |.||. .|||.|    .  .||||||....||  ......|||||||| |..|||||||||...||.| | |||...
svkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengr

AKCNQYWPDTHGYgVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftmpGPAVVHCSAG
 || ||||.. |   ...||...||...  ...|||..|. ...|.   .|.| |..||||||.|||..|....||| . |.|...    || |||||||
ekcaqYwplelgg.gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg....gpivVHCsaG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
.||||.|| .|. .. ||.....||. .|. .|. | |||||..||.||...|.||.|..
vGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 415-670 2.3e-75 248.6 In-house 34-284 (319) alignment
Range on Protein: 415-670
Range on HMM: 34-284/319.0
IPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAK
.. |.|  .      ..|||| ..|.  ..||||    |. .||||||.|| ||. . ...||||.||  || ||||||||... ...| |.|||.   |
eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvk

CNQYWPDTHgygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHV-TREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGI
...|||...     |.|| . ||. .. . .||    . ....  .| |||| |. ||.||| .||..  |..|.| . |.|||  |  || |||||||.
lkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPivvhCsaGv

GRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||| ||  |. .  ..| ...||  .| ..|  |  |||...|| |....| |...
GRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 416-670 3.9e-85 280.7 In-house 33-281 (318) alignment
Range on Protein: 416-670
Range on HMM: 33-281/318.0
PANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
....||.. . .  . |||| ..|.  ..|| |  . |  .|||||||.| ||| ..|||||.|.||| || ||||||||| ..||.| | ..||  ||.
eetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv

NQYWPDTHgygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmPGPAVVHCSAGIGR
..|||.      ...||...|.....|. .||.| .| |.. | . .|.|  | ||.||| |||....|..|.. ....  .. .  || |||||||.||
hryWPskg....srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpivvhCsaGvGr

TGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||||  || .. ... ...||. .| ..|. |  ||||.|||.|....| |. .
tGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 416-670 4.1e-54 178.3 In-house 27-278 (287) alignment
Range on Protein: 416-670
Range on HMM: 27-278/287.0
PANMTSMNEIPSgaQEKNRYCDVLPNPNSRVVLfLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
.| . . .|. .   .||||.||||  ..||.|  . |   |||||||.. .|. . .|.||.|||.. |. ||||.|.|.|....|. |  ||    ||
tatfkaaeelaa..vkknryadvlPiddtrvll.saegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

NQYWPDTHGYGVTEtyGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRS---RESFTMPGPAVVHCSAG
 .|||. .        |   | . ... . .|.  .. . .|| . .| |  . . .||| ...    ... | |. ..    . . .  || |||...|
ykywPerevPmrvG..GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||.|...   . .. ||..  .|| ..|. .|. | ..||.  |. .| . |  | |
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 416-503 6.6e-10 33.0 In-house 26-115 (347) alignment
Range on Protein: 416-503
Range on HMM: 26-115/347.0
PANMTSmNEIpSGAQEKNRYCDVLPNPNSRVVLFL---KFGIAN--SDYINANFIRgYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIM
|...|| .|    . .|||  ||  . ..||||     | . |.    ||||  |. .   || || || ||| |. |||.||   . | .. 
pskfts.vew.ekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 417-668 7.1e-37 121.7 In-house 43-288 (305) alignment
Range on Protein: 417-668
Range on HMM: 43-288/305.0
ANMTSMNEIPSGAQEKNRYCDVlPNPNSRVVLFLKFGiaNSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCN
 ..   |. .  |. |||| || |  .  .|.. |     |||| ||..       | .|..||||  || .|| || ...   |.|    ||    || 
qvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QYWPDTHGYGVTETYGDI--QVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResftmpGPAVVHCSAGIG
|||| ..|  ..   | .  .|.  | .. .     | |        .  | |  .|.||| |||    . ...|   | |.       | |||||||||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk......vpivvhcsagig

RTGVFIGADIGMRELEE-TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
|||  .  .  . .. |  .   .  .|  .|..|   .|.  ||.|.|... .|
rtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 418-670 1.5e-69 229.3 In-house 30-277 (281) alignment
Range on Protein: 418-670
Range on HMM: 30-277/281.0
NMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQ
. |.        ..|||| ..    ..||..  .    |.|||||||. ||.|. |.|||||||.| ....||.|||||. ..|.| |  .| .  || .
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChr

YWPDTHGygvTETYGDIQVTVRKKVNHNDYTLTTFLVqHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMpGPAVVHCSAGIGRTG
|||| .    . .|||..|.  .. ... |   .| . . |   |||| .  ||.||| |||.... ...|  | .. .|. |   | |.|||||.||||
YWPddns...elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtG

VFIGADIGMRELEE-TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
..|. |  ....|. ....||  .||..|..|  ||||  || |..|.. .. .
tyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 418-672 2.1e-62 205.6 In-house 35-286 (290) alignment
Range on Protein: 418-672
Range on HMM: 35-286/290.0
NMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIA--NSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
. | . .. |  ...||. ..... . |..|  . |    . .|||| .| ||. . |.|||||||.. |..|||...|....|.|.| |  .| .  ||
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkC

NQYWPDThgyGvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLER-HVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmPGPAVVHCSAGIG
.|||||.   . |..|| ..... .  ..|.|. ... |.. .  . ...|..|  |||.. |   ||....  . |  . .   .  .. |||||...|
qqYWpds...d.tkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvg

RTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
|..||. |....   . .. |||. .. ..|. . |.|||..|| ....|. .| ...
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 419-480 1.9e-07 25.2 In-house 34-95 (95) alignment
Range on Protein: 419-480
Range on HMM: 34-95/95.0
MTSMNEIPSGAQ----EKNRYCDVLPNPNSRVVLFLKfgiANSDYINANFIRGYRgQSKAYIATQG
|||      |.      |||. ...|   .||||  |    .|||||| |. ||  . ..|||.||
mtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgya.rkncyiaaqg

subfamily_PTPN3_pd Subfamily PTPN3 420-663 2.1e-66 218.7 In-house 33-269 (280) alignment
Range on Protein: 420-663
Range on HMM: 33-269/280.0
TSMNEIPSGAqEKNRYCDVLPNPNSRVVLFlkfgIANSDYINANFIRGY---RGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCN
.|.   |  . .|||| |.||  . || |      ...||||||..       |... ||||||||. | .|||.|||||....|.| | ||||   || 
isaarkpenl.sknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPDTHGygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRT
||||.|.    . .||...|...|. ... | |  ..... | .  |....  |..||| ||||.......|. . |. |..  .  | |||||||||||
qyWPeted...eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrt

GVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
||.|  .. .  .|... . .| || .||. |. .|||..|| |. .
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 420-697 5.1e-63 208.3 In-house 51-318 (319) alignment
Range on Protein: 420-697
Range on HMM: 51-318/319.0
TSMN--EIPSgAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTglvernMAKCNQ
. ..  ...   ..|||. ..|.  ...| |    |.  |||||| |. ||. . . |||.||||. |.||||||.||.... |.. |        || |
adqtfanldq.nkdknriinilafdknvvklerliGeefsdyinasfvtGyqrk.dkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPDThgygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRT
|||      . ....  .| |    . ..|..  . . .  . .  |..  . .  |||.|||| || .. ..   |  ..    . . |||||||.|||
ywplk....ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYaKRIGYVVPRIHGMNDFEEERYSENDLDD
||.|  |. .  ..| ...|| ..| ..||.|  .||   || |..  | |  . .|.    .  .  . ||. ...|.||
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee.hlfghsdvampdfpayleelsnksdfdd

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 420-587 1.8e-09 30.7 In-house 19-163 (169) alignment
Range on Protein: 420-587
Range on HMM: 19-163/169.0
TSMNEIPsGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINAnfirgyrgqskayiatqgplpftiadfwRMVWEQRTTVIIMTTGLVERnmakcNQYW
  | |.    . ||| .  |   . || |   .    ||||||                            ||.||  ..||..  .  ..     |..|
nfmaelt.cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddk.....nnfw

PDTHGYGV------TETYGDIQVTVRKKVNHNDYT-----LTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVD
|.   | .       | | |       ||. |          ...... ...|| ..  . |. ||. |||..|  |  
pekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvgh

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 420-587 2.8e-09 30.0 In-house 18-162 (169) alignment
Range on Protein: 420-587
Range on HMM: 18-162/169.0
TSMNEIPsGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINAnfirgyrgqskayiatqgplpftiadfwRMVWEQRTTVIIMTTGLVERnmakcNQYW
  | |.    . ||| .  |   . || |   .    ||||||                            ||.||  ..||..  .  ..     |..|
nfmaelt.cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddk.....nnfw

PDTHGYGV------TETYGDIQVTVRKKVNHNDYTLT-----TFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVD
|.   | .       | | |       ||. |   .      ...... ...||...  . |. ||. |||..|  |  
pekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 422-670 2e-39 130.2 In-house 26-260 (267) alignment
Range on Protein: 422-670
Range on HMM: 26-260/267.0
MNEIPSGAQEKNRYCDVLPNPNSRVVLFLKfgiaNSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMakcNQYWPD
   |..  ||.||. |.||  ..||.|  |    . .|||| .. ||. . .|.|.||.||  ||.||. .. .|. .||.. |   . |.   ...|| 
sqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdni...rlfwPP

THGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQhLERHVTREVIHYWYTNWpDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRTGVFIG
  |   .. | |. |    . . ||| . |. .. ..   ...|  |.| .| .. . ..|     | . ..   |      | ||.||.|.||.| |. 
kmg..qakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw.nintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflv

ADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
.|  .. . . .. |.   . ..|. | |.|.||..|...|..| |||.
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

subfamily_PTPN14_pd Subfamily PTPN14 423-671 4.2e-59 195.0 In-house 44-298 (300) alignment
Range on Protein: 423-671
Range on HMM: 44-298/300.0
NEIPSgAQEKNRYCDVLPNPNSRVVLFLKFGIaNSDYINANFIRGY-RGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPD
 . |   .||||. ||||  ..|| |       ...||||  |.    |... ||..||||. |. |||.||||| ...|.| |   |    |. .|.|.
aklpe.naeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

THGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFT-------MPGPAVVHCSAGIG
..    | ..|  .|| . . . . .. |.. ..||  .  |.|.|  ||.||| |||..... ...| | .  |. ..       .  | .||||||.|
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
|||| | .|. .  ||  . ||. ...| .|. |  .|||  || |..|.| .| |.
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 423-668 5.6e-43 142.1 In-house 35-276 (307) alignment
Range on Protein: 423-668
Range on HMM: 35-276/307.0
NEIPSGAQEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDT
 |  |  ..|||| ||    ..|.|.  ||  . |||| ||.. |   . | .|..||||  |. .|| |. ...   .||   ..|    ||.||||  
veafsantdknryqdvkcqdkgrivv..kfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

HGYgvTETYGDIQVT--V----RKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftmpgPAVVHCSAGIGRT
.|   . ..|.   |  |     ||.  ..  .    ..    . .| . |. ..|||| |||.   . ...|  .|  ..      | |||||||.||.
egq..klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn......pvvvhcsaGvGrs

GVFIGADIGM-RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
|  ..  . . . ..     |. ..| ..|..|   .||. ||..||..| ||
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

DSPc_SM00195 424-669 3.9e-82 270.9 In-house 21-262 (263) alignment
Range on Protein: 424-669
Range on HMM: 21-262/263.0
EIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTH
.. .  ..|||| ..||. ..|| |  . .  .|||||||.|.|.  ..|.||||||||| |..||||||||.....|.|.|  .|..  ||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

gyGVTETYGDIQVTVRKKVNHN-DYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFtmPGPAVVHCSAGIGRTGVFIGA
  | .||.|.|.|..... ... ...|.|. ... ... ||.| .|.|.|||| ||||...||...| . . |...    || |||||||.||||.|. .
..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvti

DIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|| ...|||....|.  || ..|. | |||||..|| |..... ||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 424-669 3.9e-82 270.9 In-house 21-262 (263) alignment
Range on Protein: 424-669
Range on HMM: 21-262/263.0
EIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTH
.. .  ..|||| ..||. ..|| |  . .  .|||||||.|.|.  ..|.||||||||| |..||||||||.....|.|.|  .|..  ||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

gyGVTETYGDIQVTVRKKVNHN-DYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFtmPGPAVVHCSAGIGRTGVFIGA
  | .||.|.|.|..... ... ...|.|. ... ... ||.| .|.|.|||| ||||...||...| . . |...    || |||||||.||||.|. .
..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvti

DIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|| ...|||....|.  || ..|. | |||||..|| |..... ||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 424-669 2.5e-57 189.1 In-house 42-278 (287) alignment
Range on Protein: 424-669
Range on HMM: 42-278/287.0
EIPSGAQEKNRYCDVLPNPNSRVVLFlkfgIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTH
.| |  ..|||. ..|.  | ||.|       . ||||| || ||. ..||.|....|.  |. .||....... |.|.| . . | .  .| ||||...
niasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

GygvtETYGDIQVTVRKKVNHNDYTLTTFLVQHLERH-VTREVIHYWYTNWPDMGVPDNPSSVVDFLlETRRSRESFTMPGPAVVHCSAGIGRTGVFIGA
      ..|. .... ..  ...|.  .. |.. ...  ...|  | .|||.. |   .| ...  . | .   .     .. |||||...||...|. |
s....vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.eemyktqrkrgntsivvhCsdtvGrsamfcaa

DIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
...... ..   |||.... ..|. . |.||| .|| |. .|. || 
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_PTPN23_pd Subfamily PTPN23 425-672 3.8e-63 208.0 In-house 39-283 (288) alignment
Range on Protein: 425-672
Range on HMM: 39-283/288.0
IPSGAQEKNRYCDVLPNPNSRVVLFlkfgIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHG
|     ||||. |.||  ..||.|       . ||||| |...   ..  .||||.||. |..|||.||.||.. ||.| .   |..  |...|||  .|
iaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

ygVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRS--RESFTMPGPAVVHCSAGIGRTGVFIGA
   |...||..||.... . . .   .. ...|. . ...| |  .|.||..|||. |.....|| | . .   .   .  | |||||||.||||||   
..etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DIGMRELEETQ-MIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
   .||||. . ..|....|  .|..|  |||.|.|. |. ..  |.|.|.
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 425-698 1.3e-62 206.9 In-house 22-283 (284) alignment
Range on Protein: 425-698
Range on HMM: 22-283/284.0
IPSgAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTglvernMAKCNQYWPDThg
..   ..|||. ..|.  ...| |    |.  |||||| || ||. . . ||||||||. |.||||||.||.... |.. |        || ||||    
ldq.nkdknrighilafdknvvklerliGeefsdyinasfitGyqrk.dkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk..

ygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGAD
  . ....  .| |    . ..|..  . . .  . .  |..  . .  |||.|||| || .. ..   |  ..    . . |||||||.|||||.|  |
..ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

IGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYaKRIGYVVPRIHGMNDFEEERYSENDLDDH
. .  ..| ...|| ..| ..||.|  .||   || |..  | |  . .|.    .  .  . ||. .. |.|| 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee.hlfghsdvalpdfpayleelsnksdfddd

0046845 (Phosphotyrosine protein) phosphatases II 427-674 3.5e-90 297.5 In-house 26-279 (284) alignment
Range on Protein: 427-674
Range on HMM: 26-279/284.0
SGAQEKNRYCDVLPNPNSRVVLFLKFG-IANSDYINANFIRGYR----GQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPD
   ..|||| |.||. .|||.|    | . .||||||....||      ..|..|||||||| |..|||||||||...||.| |.|||... || ||||.
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

ThgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLE-RHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFI
.   | . ||||..||.... ...|||..|. ...|.    .|.|.|..||.|||.|||..|.....|| . |...|..  .|| |||||||.||||.||
e...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

GADIGMRELEETQ---MIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGY
 .|. .. ||...   ..||| .|. .|. | ||||| .||.|....|.||.|.. .
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0045098 (Phosphotyrosine protein) phosphatases II 427-672 6.5e-79 260.5 In-house 31-275 (278) alignment
Range on Protein: 427-672
Range on HMM: 31-275/278.0
SGAQEKNRYCDVLPNPNSRVVlflkfgiansDYINANFIRGYrgqSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyG
 | ..|||| |.||...|||.          |||||..|.||   .|..|||||||| |.||||||.||...|||.| |.|||... || ||||.    |
lgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe....g

VTETYGDIQVTVRKKVNHNDYTLTTFLVQHL----ERHVTREVIHYWYTNWPDMGVPDNP--SSVVDFLLETRRSRE-----------SFTMPGPAVVHC
 ..||||..||. .  ...||||.|.||..|    |   .|.| |..|..|||.|||..|  .|. ..| . |. ..            .  .|| .|||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGVFIGADIGMRELeEtQMIDVLRIVANMRQDRGG-MVQTKDQYVFLHKILYEYAKRI
|||.||||....|.. .. | | . .|.| .|. .|. |.| .||...||.||.. |.|. .|.
saGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_PTPRG_pd Subfamily PTPRG 427-668 3.9e-74 244.9 In-house 45-286 (563) alignment
Range on Protein: 427-668
Range on HMM: 45-286/563.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANS-DYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgy
   ..||||.....  .||| |    |. .. ||||||.| ||. .|||.|||||||. |. |||||.|||....|.| | ||||.  ||..|||     
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk....

GVTETYGDIQVTVRKKVNHNDYTLTTFLVQHL--ER----HVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETrrSRESFTMPGPAVVHCSAGIGRTGVF
  .|||| .|||  ..  .  ||  |. ...|  ..    .  ..|..| ||.|||.|||. .  |. |      |.   .  || |||||||.||||..
desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtGty

IGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
|  |  ...... ....|....  .|  |  .|||..||.|||..| | 
ivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea

subfamily_Ptp69D_pd Subfamily Ptp69D 427-670 2.4e-68 225.6 In-house 43-287 (307) alignment
Range on Protein: 427-670
Range on HMM: 43-287/307.0
SG---AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTh
|     . |||| |. .  . ||.|    | ..||||||.||.||. ..| .|| |.|.  || |||||..||  |.|.| . | | | .||..|||.  
sekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.

gygVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHV-----TREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRsRESFTmPGPAVVHCSAGIGRTGV
    .  |||| |.. .. .|.||.  .. | . . ..     .|.|. | ||.|.|. ||. . ...... . |   ...   .| ||||||| ||.|.
...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre.lykln.rsPivvhCsaGvgrsgi

FIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|.  |. . .|.. . .|.  .| ..|..|  .||  .|||||.. | .| .
fvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPRK_pd Subfamily PTPRK 427-667 6e-66 217.4 In-house 41-275 (314) alignment
Range on Protein: 427-667
Range on HMM: 41-275/314.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgyg
   .||||. |.|.  .|||.|    | ..||||||..| .|. ...|.|.|||||. |..||||.|...... |.| | |||    || .|||.     
denreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed....

vTETYGDIQVTVRKKVNHNDYTLTTFLVQHLER--HVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRTGVFIGADI
 ||.||||.|.. .   ....   .| |..|.|  . .||| .. ...||| .|| .  ...... .   |.|     |. ||||||| ||||.||  ||
.tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidi

GMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
 .  .|. ...||  .| ..|. .  ||.|..||.|.. .. |
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_PTPRN_pd Subfamily PTPRN 427-665 2.5e-52 172.4 In-house 54-288 (297) alignment
Range on Protein: 427-665
Range on HMM: 54-288/297.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThGYG
  . .|||. .|||  .||| |  .    .|||||| .|     .. |||||||||. |.||||.||||| ..||.. | | | .. .|..||||. |  
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde.Gse

VTETYgDIQVtVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRTGVFIGADIGM
| . | .... | ...  .|| . .| .. |. . || |  . .  ||..||| .. |...|     .|        | |||||.| |||||.|  |. .
vyhiy.evhl.vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvl

RELE-ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKIL
  |    . ||.   .  .|..| |.|.||||. |  . .
nrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_CG7180_pd Subfamily CG7180 427-668 1.2e-46 153.7 In-house 40-289 (296) alignment
Range on Protein: 427-668
Range on HMM: 40-289/296.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDTHgyg
.  .||||. .|.|  . ||||    | ..|||||| .. ..  . |.|| |..|   |. .|||.|... .  ... |   . .  ....||| .    
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...

vTETYGDIQVTVRKKVNHNDYTLTTFLVQHL----------ERHVTREVIHYWYTNWPD-MGVPDNPSSVVDFLLETRRSRESF---TMPGPAVVHCSAG
  | ||.| | . .. .  . .  || ...           .   || | .. .| |.    ||   .......   |  ||      . || ||..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
 .|.||....|. .  .|... .|| . |  .|..| ..|.....| ..  .| |.
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

0049772 (Phosphotyrosine protein) phosphatases II 427-673 4.7e-46 153.3 In-house 45-284 (314) alignment
Range on Protein: 427-673
Range on HMM: 45-284/314.0
SGaQEKNRYCDVLPNPnSRVVLfLKFGIANSDYINANFIRGYrgqsKAYIATQGPLPFTIADF----------WRMV--WEQRTTVIIM-----------
 . ..|||| |.|| . .||.|  .... .||||||....|.    ...|||||||. |. ||          ||||  ..... .| |           
ln.rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------TTGLVERNmakcnqywpdthGYGVTETYGDIQvtvrkkvnhndytlttfLVQHLERHVTREVIHYWYTNWPDmGVPDNPSSVVDFLLETR
           ..| ...            .. . ... ...                  ...   ...|..|.|.....|| | .. .. . .||   .
rLdaAlgKtpllildgng............neptaadlellk.................eelydpelferlgikylripvpD.gsaplledfdeflefie

RSresfTMPGPAVVHCSAGIGRTGVFIGADIGMRELeetQMiDVLRIVANMRQDRG-----GMVQTKDQYVFLHKILYEYAKRIG
.       .|| .|||.||.||||.|. |.. |. |   .. ..  ... .|. |      |.... .||.| ...|.|| |.. 
ea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 427-555 3.8e-24 80.1 In-house 43-183 (350) alignment
Range on Protein: 427-555
Range on HMM: 43-183/350.0
SGAQ--EKNRYCDVLPNPNSRVVLF--------LKFGIANSDYINANFIRGY----RGQSKA-YIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERN
.| .   |||| ..||   ||| |          |  .  .||||||...      . ...  |||||.||| |. ||.... .   .||.. | .|| |
eGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

MAKCNQYWPDThgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQ
. ||..||..    .. .    .. . .. .. || .| .. |.
lekcyrYWqeg...sydditvklaskwenimgindsslysadvk

subfamily_PTPRB_pd Subfamily PTPRB 428-670 1.1e-83 275.7 In-house 50-286 (293) alignment
Range on Protein: 428-670
Range on HMM: 50-286/293.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHgygV
  ..|||| ..||  .||| |    . ..|||||||.|.||. . . .|||||||| |. ||||||||.....|.| | |||.   ||..|||...    
vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade...e

TETYGDIQVTVRKKVNHNDYTLTTFLVQHleRHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMR
. .||||.||. .. . .|... ......  .. .|.| .| .| ||| |||.......||. . |.. |. .  .| |||||||.||||.||  |  ..
pvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllq

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
..||....|.. |||..|..|  .|||..||.|.|. . .. .
aieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPN9_pd Subfamily PTPN9 428-671 8.4e-80 263.0 In-house 41-292 (297) alignment
Range on Protein: 428-671
Range on HMM: 41-292/297.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygV
.  ||||| |||   ..||||  . .  .||||||||. ||. | ||.|||||||. |. |||||||||.. ||.||| .|||   ||.||||....   
anleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee..s

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRES----------FTMPG-PAVVHCSAGIGRT
.. .||..|.. . ....||. ... ... . . .|.|.|. .. ||| |||.. .|..|.| . |. . .          . . | | |||||||||||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
| ||  || . .|||....||   |  .|. |  ..|| .||.| .. . |||..
Gtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 428-667 7.6e-64 210.6 In-house 48-277 (315) alignment
Range on Protein: 428-667
Range on HMM: 48-277/315.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgygv
  ..|||| ....  .||| | |     .|||.||||| ||  . . |||.|||.. .. ||||.|.|.  . |.| |.|||..  |...||||      
enkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmpGPAVVHCSAGIGRTGVFIGADIGMR
  .|| | || ...  ...||  |. |   ..   |||. . || |||||||    .....    .. ...    |. |||||||.|||| ||  |  . 
kviyGkitvtrkseevnteytvrtlsvvfgdn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavld

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
..|  ..||| ... ..|| | .|||. .|| |....| |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 428-686 1e-61 203.5 In-house 43-294 (315) alignment
Range on Protein: 428-686
Range on HMM: 43-294/315.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGV
  ..|||| ..||  ..||.| .   . .|||||| .|...  . |||||.||||. .. ||||||.....| |.| | . | .  ||.||||| ..  |
infkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

teTYGDIQVTVRKKVNHNDYTLTTFLVQHleRHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMpgPAVVHCSAGIGRTGVFIGADIGMR
   .| |.|.. .     | .   . ...   . .| |  . .|.||| ||. . ||.. .. | . .... .   . .||||||.|||||.| .|  . 
..efGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef..sllvhcsaGvGrtGvvisidevva

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVPRIHGMNDFE
....|...||...| |.|..|  .|||...| |.. .. |. .    ... ||  . ..
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 428-664 1.6e-39 130.5 In-house 32-290 (297) alignment
Range on Protein: 428-664
Range on HMM: 32-290/297.0
GAQEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRG-QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYG
..  |||| |.|   ..|| |  . .|...|||||...      .   || .||||  |. |||..|.||   ||.| . | |    ||  |||.. . .
sslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VTEtyGDIQVTVRKKV--NHNDYTLTTflVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDF----------------LLE-----TRRSRESF----
 .   ||. |    ..  ...   ||   .| . |  .| | |  . .||| ||| .   .| |                |.|          ||.    
lka..gdvvveflsstsdefdrvilte..lqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

TMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKI
  . . .||||||.||.|| . .|. .  |   .. ||  |.  .|. |  .||| .|. .|...
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

subfamily_egg_pd Subfamily egg 428-673 8.7e-27 88.6 In-house 39-275 (307) alignment
Range on Protein: 428-673
Range on HMM: 39-275/307.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERnmAKCNQYWPDTHGYGV
  .|| |   |  .  ||| | |. |    |.| || ..|       .| .| ||  |  ||||||....   |.| |  .|    .|. ||| ..   .
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVdflletRRSRESFTmpgPAVVHCSAGIGRTGVFIGADIGMR
    | ....  |  .. |  ..   .. .  .     . .|  ..  ..    |  |.      |. |.  .   |.||..  |. ...... ..| . 
vtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl......rklrnlsk...pvvvqdilGvskaatlvaieiall

ELEE--TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY-EYAKRIG
.|    .    ||| |  .|. |   |..  .|.|.....   .   ||
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvig

subfamily_PTPRD_pd Subfamily PTPRD 429-670 1e-95 316.5 In-house 48-282 (564) alignment
Range on Protein: 429-670
Range on HMM: 48-282/564.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgyGvT
 ..|||| ....  .|||||    |  .||||||.|| ||| ..||||||||||. ||.|||||||||....|.| | |.|..  ||..|||..   | |
NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek...g.t

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMRE
||||...||. .... .||...|| ... ... .||| .. .|.||| |||... |..|.. . |...|  .  || |||||||.||||.||  |. .. 
etygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamler

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
..| ...|.  .|...|..|  ||||..||.|.|....|. .
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

0045450 (Phosphotyrosine protein) phosphatases II 429-669 1.1e-82 273.5 In-house 55-304 (307) alignment
Range on Protein: 429-669
Range on HMM: 55-304/307.0
AQEKNRYCDVLPNPNSRVVLFLKFGI-ANSDYINANFI--------RGYRGqSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYW
 ..|||| |.||....||.|    |   .||||||...         ||.  ....|||||||| |..|||||.|||..|||.| |.|||..  || |||
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PDThgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGV
||.   | . |||...||....  ...||..|. |..| . . .|.|.|..||.|||.|||.......||. | |. .|. . .|| .||||||.||||.
Pde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGt

FIGADIGMRELEETQM---IDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
||.|.. .| ||....   .|.| .|. .|. |.|.||. .||.||...|.|. 
fiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0043336 (Phosphotyrosine protein) phosphatases II 429-669 2.2e-82 272.0 In-house 45-277 (278) alignment
Range on Protein: 429-669
Range on HMM: 45-277/278.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPdthgyGVT
 ..|||| |.||...|||.| |  |  .||||||... ||. . | .|||||||| |..||||||||...|.|.| |.|||... || ||||     | .
nkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggs

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMRE
.||||..||..|   ..|||..|. | .|  . .|.| ||.|..|||.|||...|...||| . |. .|  . .|| .||||||.||||.||.... .. 
ltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleq

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|| .. .|.. .|. .|. |.|.||| .||.||...|.|| 
lekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 429-670 7.4e-74 243.1 In-house 9-243 (250) alignment
Range on Protein: 429-670
Range on HMM: 9-243/250.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAkCNQYWPDTHgygvT
 .||||| |...  .|||||. . |  .|||||| |. ||... ||.|||||||. || ||||||.|. ...|.| | |.| .   ..||||  .    .
nkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek....a

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMRE
|.|||..|.. .| .. ||| ... . . ..   | | .. ...||| |||..  .|...| . ..|..  .  .| .|.||||.||.| ||  |  .  
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavler

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|.. ...|| ...  .|.|| ..|....||||...|. .. .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPN12_pd Subfamily PTPN12 429-671 1.3e-71 235.8 In-house 40-279 (290) alignment
Range on Protein: 429-671
Range on HMM: 40-279/290.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvT
 ..|||| |.||  .|||.|  . .  .|||||||||.|  |. ..|||.||||| |. |||||.||.......|   .|| .  ||..|||....   .
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee..e

ETYGDIQVTVRKKVNH-NDYTLTTFLVQHLerHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMR
 ..|...||. .. .  .|... |. |..   . .|.|  . ||.||| ||| ...|..... . |. .|  .   | |||||||.||||. |  |.  .
lefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvre

ELEETQM---IDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
 |.. ..   .||  .|...|..|  .||||.||....| . |. ..
llkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_PTPN13_pd Subfamily PTPN13 429-669 1.5e-66 219.5 In-house 37-269 (273) alignment
Range on Protein: 429-669
Range on HMM: 37-269/273.0
AQEKNRYCDVLPNPNSRVVLFlkfgiANSDYINANFIRGYRGQSK-AYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGV
 ..|||| .|||  ..|| |      ... ||||..|.   |. .  |||.||||| |..|||.|||||...||.| |  .|..  ||..|||....  .
nkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

TeTYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftMPGPAVVHCSAGIGRTGVFIGADIGMR
.  .. ..|.. | ........ .. |...|   .||| |  ...||| ||| .. ... |. | || ..     || ||||||||||.|..|  |. . 
k.vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidvvlg

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 .|  . .||  || ..|. | |.|||||||.| .|.. |  
lierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPN1_pd Subfamily PTPN1 429-671 2.2e-63 208.7 In-house 32-273 (290) alignment
Range on Protein: 429-671
Range on HMM: 32-273/290.0
AQEKNRYCDVLPNPNSRVVLflkfGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHG-YGV
 ...||| || |   ||..|      |. |||||...   .   . || |||||| |.. ||.|||||..  ..|   .||... || ||||  .    .
nrnlnryrdvspydhsrikl....eradndyinaslvelee.akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMR
.     ..|.. .. ... ||. .. .. |. . |||..|. || |||.|||. |.. ..|| . |.|    .  ||||.||||||||.| |. .|  . 
lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

ELEETQM---IDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
..|...    .|. . . ..|. | |..||.||  | .  . | || 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 429-669 2.8e-57 189.3 In-house 48-288 (325) alignment
Range on Protein: 429-669
Range on HMM: 48-288/325.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLvERNMAKCNQYWPDTHGygVT
 ..|||. .|..  .|||||  |   ..||||||...| .... . ..|.| ||. || |.||.| . |..|....  | . .  .| .|||.  |   .
nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemg..ks

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTM----PGPAVVHCSAGIGRTGVFIGADI
 |.| ..| .|   .  ||    . |.  ..  || |  . .  |.||||.  |.... .|       |  |      .| .||||||.|||||||    
ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislys

GMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 . .. |   .|..  | ..|.||  ||.| |||..... | |. 
alakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 429-667 1.2e-52 173.8 In-house 48-277 (439) alignment
Range on Protein: 429-667
Range on HMM: 48-277/439.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMakcnqYWPDTHgygvT
 | |||| || .   .||.|    |.  | |||||.|.||  . | |||||||   |  ||||.|.|..|. |.| | |||        |||        
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda....e

ETYGDIQVTVRKKVNHNDYTLTTFLVQHL--ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSrESFTMPGPAVVHCSAGIGRTGVFIGADIGM
  |||| | | ....  .|..  | |       .  | |... |. |||  || . | |.|||     . .     || |||||||.||||  |  || .
vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa.ndkeeygpvvvhcsagvGrtGtiialdial

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
 .|   . .|.  ||  .|..|  |||.  ||||... . |
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 429-671 1.1e-39 130.9 In-house 48-289 (305) alignment
Range on Protein: 429-671
Range on HMM: 48-289/305.0
AQEKNRYCDVLPNPNSRVVLflkFGIANSDYINANFIRGyRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVT
 ..|||| ||    | || |    |    .|| ||..     ..| .| || ||  | |||| | ....   |.|   |.|.   || .|..  ..  ..
eagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

ETYGDIQVTVRK----KVNHND----YTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResftmpGPAVVHCSAGIGRTGVFI
   .. ...|.     ... ..        | ||     . .| | || . .||| |||    .....| ..| |.      || ||||||||||||  .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvv

GADIGMRELEETQMID-VLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
  .  . .| . |.|.   .|.  .|..|   .|| .||.|.|... .| ..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 429-669 3.5e-38 125.9 In-house 37-269 (281) alignment
Range on Protein: 429-669
Range on HMM: 37-269/281.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANS-DYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygV
 ..|||| ..     ||| | .|.   || ||| ||.||      . || ||||   | ||||||.|.. || |.|   ..| |  || .|.|      .
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah..c

TETYGDIQVTVRKKvNHNDYTLTTFLVQHLERhVTREVIHYWYTNWPDMGVPDNpSSVVDFLLETRRSRESftmpgPAVVHCSAGIGRTGVFIGADIGMR
   .  . |.       |   .|| |    |   || . |. . .|||  ||.  | |.  .|   |.| .     | |.|||||.||.| ..  .| ..
clqfdklsvsyeds.tvnkslvttrlnlsyeg.etrlithwlwkewpdwqvpes.sevmlkilrkirarst.....ppvihcsagvgrsgtlmaveialq

ELEET-QMIDVLRIVANMRQ-DRGGMVQTKDQYVFLHKILYEYA
 .     . |. .||. .|   |   ||| .||... |.| .. 
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 429-673 9.7e-35 114.9 In-house 35-274 (285) alignment
Range on Protein: 429-673
Range on HMM: 35-274/285.0
AQEKNRYCDVLPNPNSRVVLflKfgIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVT
  . |||.||    ..||||  |    . ||| |...|    .  .||.|||||| |..|||.|..... . ..|   |.|  . ||  |.|.  |  | 
npdlnryadvrcieetrvvl..k..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTRE--VIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResfTMPGPAVVHCSAGIGRTGVFIGADIGM
    .| .|  |.       | .. |   |   .    . |     |||   |..   ....    ..         | .||||||.|||  |.| |   
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagvgrtatfvgidyat

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIG
  . |   |..| || .||  |   ||.. |..||. .| ||    |
irimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg

0040438 (Phosphotyrosine protein) phosphatases II 430-677 6.1e-86 283.9 In-house 44-284 (317) alignment
Range on Protein: 430-677
Range on HMM: 44-284/317.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyGVTE
..|||| |.||...|||.|    |. .||||||... |.. . | .|||||||| |..|||||||||..|||.| | |.|..  || ||||.    | | 
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl....getl

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMREL
||||..||... . ....||.|. |..|.   .|.| |..||.|||.|||..|....||| . |...|    .|| .||||||.||||.||.|.. .. |
tygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleql

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVP
|... .||  .|. .|. |.|.||| .||.||...|.|| || .. .|
ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep

0039614 (Phosphotyrosine protein) phosphatases II 430-672 4.8e-85 280.9 In-house 57-292 (297) alignment
Range on Protein: 430-672
Range on HMM: 57-292/297.0
QEKNRYCDVLPNPNSRVVLFLKFGI-ANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDTHGygvt
..|||| |.||...|||.|  . |   .||||||... ||.  ....|||||||| |..|||||||||..|||.| | |||... || ||||.. |    
kdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....

eTYGDIQVTVRKKVNHNDYTLTTFLVQHleRHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRE
 ||||..||..|   ...||..|. |..     .|.| |..||.|||.|||...... .|| . |. ...   .|| .||||||.||||.||.|.. .. 
.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
||... .||| .|. .|. |.|.||| .||.||...|.|. ||.
lekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0040439 (Phosphotyrosine protein) phosphatases II 430-669 3.1e-79 261.4 In-house 12-246 (249) alignment
Range on Protein: 430-669
Range on HMM: 12-246/249.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyGVTE
..|||| |.||...|||.|    |   ||||||..| ||. . . .|||||||| |..|||||.||.. |||.| | |||... || ||||.    | . 
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....ggsl

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMREL
.|||..||...   ..|||..|. ...|.   .|.| |..||.|||.|||.......||. . |  .|.   .|| .||||||.||||.||.|.. .. |
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|... .|.. .|. .|. |.|.||. .||.||...|.|. 
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

Y_phosphatase Protein-tyrosine phosphatase 430-666 3.2e-79 261.0 Pfam-A 2-234 (235) alignment
Range on Protein: 430-666
Range on HMM: 2-234/235.0
QEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvTE
..|||| |.||  ..|| |  |    .|||||||...||. ..|..|||||||. ||.|||||||.....||.| | |.|..  ||.||||.. .   ..
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sl

TYGDIQVTVR-KKV-NHNDYTLTTFLVQHLERH-VTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResFTMPGPAVVHCSAGIGRTGVFIGADIGM
|||||.|... |.  ....|||... ... ...  .||| ...|||||| |||..|.|..|.. . ..|.   .  || |||||||.||||.|. .|| .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
..||... .||| || ..|. | ||||. .||.||.|.. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 430-666 3.2e-79 261.0 In-house 2-234 (235) alignment
Range on Protein: 430-666
Range on HMM: 2-234/235.0
QEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvTE
..|||| |.||  ..|| |  |    .|||||||...||. ..|..|||||||. ||.|||||||.....||.| | |.|..  ||.||||.. .   ..
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sl

TYGDIQVTVR-KKV-NHNDYTLTTFLVQHLERH-VTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResFTMPGPAVVHCSAGIGRTGVFIGADIGM
|||||.|... |.  ....|||... ... ...  .||| ...|||||| |||..|.|..|.. . ..|.   .  || |||||||.||||.|. .|| .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
..||... .||| || ..|. | ||||. .||.||.|.. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0042113 (Phosphotyrosine protein) phosphatases II 430-669 8.9e-79 259.6 In-house 10-243 (245) alignment
Range on Protein: 430-669
Range on HMM: 10-243/245.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyGVTE
..|||| |.||....||.|    |   ||||||... |||   | .|||||||| |..|||||.||.. |.|.| | ..|... || ||||.    | . 
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....gesl

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMREL
||||..||...  ...|||..|. |..|  . .||||||.|..|||.||||......||| . |. ... . .|| .||||||.||||.||.|.. .. |
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleql

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|... ...  .|. .|. |.|.||| .||.||...|.|. 
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPN6_pd Subfamily PTPN6 430-671 1.5e-75 249.0 In-house 55-299 (306) alignment
Range on Protein: 430-671
Range on HMM: 55-299/306.0
QEKNRYCDVLPNPNSRVVLFlKFGIANSDYINANFIR-GYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHgygVT
.|||||  .||  ..||.|  . ....|||||||.|.   .|..|.|||||| |. |..|||||||.. ..||.|||  |||.  || .||||..    .
keknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee...ek

ETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFT--MPGPAVVHCSAGIGRTGVFIGADIG
|.||.|.||  .. ...||.| ...|..  . . .|||..| ...||| ||| .|. |.||| . .| .|...   .|| |||||||||||| ||  || 
eeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

MRELEETQ---MIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
.. .|..     ||. ..|  .|. | |.|||..|| |..|.. .| ..
lkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

0037934 (Phosphotyrosine protein) phosphatases II 430-668 5.2e-72 237.6 In-house 11-241 (243) alignment
Range on Protein: 430-668
Range on HMM: 11-241/243.0
QEKNRYCDVLPNPNSRVVLflkfgiANSDYINANFIRGYRgqsKaYIATQGPLPFTIAD----FWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPdthgY
..||||.|.||...|||.|       .|||||||.|....   . .|||||||| |..|    ||||.||...|||.| | |||... || ||||     
lsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....g

-GvteTYGDIQVTVRKKVNHNDYTLTTFLVQHLE-RHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRES------FTMPGPAVVHCSAGIGRTG
     ||||..||. .  ...|||..|.|...|.  ..||.||||.|..|||.||||.|....||| |.|   |.          || .||||||.||||
ev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

VFIGADIGMRELeetQmIDVLRIVANMRQDRGG-MVQTKDQYVFLHKILYEY
..| |.. .. |   . .|.. .|. .|. |.| .||| .||.||...|.|.
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 430-666 2e-64 212.1 In-house 4-236 (237) alignment
Range on Protein: 430-666
Range on HMM: 4-236/237.0
QEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygvTE
. |||| ..     |||||  |   ..||||||....|. |  | |||.||||  .  |||.|||... .||.| |||.|.|  || .|||.|.     .
kiknrygnivaydhsrvvl..kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq...pa

TYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRE
.|| . |...|| .  |||. ..|... |. .  | .  | .| ||| |||.. .... |  .     .  .  || ..|||||.||||.|.  |  .|.
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
 .| ...|.   | .. .||  ..||||||||.|. . 
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 430-686 4.8e-62 204.7 In-house 44-293 (515) alignment
Range on Protein: 430-686
Range on HMM: 44-293/515.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVte
 .|||| ..||  ..|| | .     .|||.|| .|...    |||||.|||.. .. ||||.|.....| |.| | | | .  || .||||  |  |  
fkknryknilPydsvrvklevindnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv..

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmpGPAVVHCSAGIGRTGVFIGADIGMREL
 .| |.| .       . .  .. | . .   .| |  . .|.||| ||| . ||.. .. | . ... .|   | ..|||||.|||||.| .|  . . 
kfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvaha

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVPRIHGMNDFE
..|.|.||...| |.||.|  .|||..|| |.. .. |. .    ..| ||  . ..
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 430-666 6.8e-61 200.4 In-house 8-237 (239) alignment
Range on Protein: 430-666
Range on HMM: 8-237/239.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgygvTE
. ||||....    |||||        ||||||...| | |  |||||||| .  .  |||||.|..|  ||.| |||.|    || |||||.     | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....ts

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDflLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMREL
 | ...||.||     || . ||.. .. .   | | .| .| ||| |||.  ..|.   |  . ...|.    | |.|||||.|||| |.  |  .|. 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg..lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
.. . .|..  |  .|.||  |||| .||||.|  . 
kkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 430-665 7.8e-61 200.3 In-house 9-237 (239) alignment
Range on Protein: 430-665
Range on HMM: 9-237/239.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgygvTE
. ||||....    |||||        ||||||...| | |  |||||||| .  .  |||||.|..|  ||.| |||.|    || |||||.     | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....ts

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDflLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMREL
 | ...||.||     || . ||.. .. .   | | .| .| ||| |||.  ..|.   |  . ...|.    | |.|||||.|||| |.  |  .|. 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg..lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKIL
.. . .|..  |  .|.||  |||| .||||.|  .
kkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 430-668 1.8e-59 196.3 In-house 52-283 (297) alignment
Range on Protein: 430-668
Range on HMM: 52-283/297.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGqskAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDThgyGvTE
 ||.|| ..||   ||| |       .|||.|| |..|..     .|.|| | . |.||||.||.......|.| . . ||.  || .||.|.   | . 
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk...g.vt

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPD--NPSSVVDFLLETRRSRESFTMPgPAVVHCSAGIGRTGVFIGADIGMR
|.||. |..    . . .   .. |.. .  ..| |  | ...|||  |.   . ||..... | | . .. .   | .|||.||.|||||..  |  . 
tfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvva

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
| .... .|.. .|  .||.|  .||||.|| |..... |.
eakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 430-670 8e-39 128.0 In-house 53-291 (310) alignment
Range on Protein: 430-670
Range on HMM: 53-291/310.0
QEKNRYCDVLPNPNSRVVLFLKFGiANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgYGVTE
  ||||.||.   .||| | .       ||| ||...    . ...| .||||  || |||||....|.  |..    .|    ||  |||     ||||
mhknrysdvvcldtsrvklkidks.ryedyihanyvktnylr.stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps...lgvte

TYGDIQVTVRKKVNhNDYTLTTFLVQHLERHVT-------R---EVIHYWYTNWPDMGVPDNPSSVVDFLLETR-RSresftmpGPAVVHCSAGIGRTGV
||| |.||   .   ... .  . |  .   |             |    . ||||.||||.    |   | .. |        || |||||||..|..|
tygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdrlyv

FIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
 .  .. .  |.. . .|.  ........|   .||. ||......   .|.
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar

subfamily_ptpA1_pd Subfamily ptpA1 430-630 3.7e-38 126.4 In-house 48-257 (418) alignment
Range on Protein: 430-630
Range on HMM: 48-257/418.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHG-----
  |||| ..||   .|| |        |||||||.| |     | .|.|||||| |||||||||||.|  .|.| .   |    ||..|||.  |     
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

-YGV-TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDfLLETRRSRESFTMP-----GPAVVHCSAGIGRTG
 ||   | .|   | . . ..  .  . |  ..      ||.. .| |  |||  .||    . . || .   |.   .|      | .||||||.||||
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrq.llhsitnrqnqiipssdrnvpiivhcsagvgrtg

VFIGADIGMRELE
 |  | | |..|.
tfctavimmkkld

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 430-661 3.4e-35 116.2 In-house 51-273 (301) alignment
Range on Protein: 430-661
Range on HMM: 51-273/301.0
QEKNRYCDVLPNPNSRVVLfLKFGiaNSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVTE
..|.||  |  .|.. | . .. |  .   | ||.|    |... .|||||||. |  ||| |.       |.| .  ||... ||..| | . .  .  
kdkhryptvPckPstavev.ivdG..krvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

TYGDIQVTVRKKVNHNDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftmpgPAVVHCSAGIGRTGVFIGADIGMRE
   .|... .... ... .  |. |.   ..  || |.|| |..|.| |||     . |..   ..|..      | ||||||||||.  |||...  ||
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylare

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFL
.|  . |.. . ....|..|   |||. |  ..
veadptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 430-675 7.4e-20 65.8 In-house 48-285 (303) alignment
Range on Protein: 430-675
Range on HMM: 48-285/303.0
QEKNRYCDVLPNPNSRVVLflkfgiANSDYINANFIRgYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVTE
 .|||..||.    |.| |      ..| || |...      ||  | || ||. | ||||.|. ||.  ....     | .    .  .|    .   |
mdknrfvdvicldhskvkl......sdssyihasyle.l.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

TYgDIQVTVRKKVNHND-YTLTTFLVQHLERHVTREVIHywYTNWPDMGVPDN-PSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMR
    |.|   |.|.  | ..|    |   . .    | |  | .||   .| .  . .|  . . .     ..   |.|    .| ||.| |   .    
er.sirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

EL-EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYV
 | .|   .|... . |.|. |   ||   |. ... .| |.    |..
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngic

0041856 (Phosphotyrosine protein) phosphatases II 431-675 1.3e-51 170.1 In-house 3-177 (182) alignment
Range on Protein: 431-675
Range on HMM: 3-177/182.0
EKNRYCDVLPNPNSRvvlflkfgiaNSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTglvernmakCNQYWPdthgygvtet
.|||| |.||...||          ..||||||...|.. ... .|||||||. |.|||.||..|.. |.|.. |         . .|||          
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

ygdiqvtvrkkvnhndytlttflvqhleRHVTREVIHYWYTNWPDMGVPDnPSSVVDFLLETRRsresftMPGPAVVHCSAGIGRTGVFIGADIGMREle
                             ...|..|.|.|..|||.|||| .....||. | ..       .|| .||||||.||||....|.. ..   
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl..

etqMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYV
    ...  .|. .|. | |||.| .||.||. .|.|. ..  ..
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 431-675 6.7e-49 161.1 In-house 58-289 (290) alignment
Range on Protein: 431-675
Range on HMM: 58-289/290.0
EKNRYCDVLPNPNSRVVLflKFGiANSDYINANFIRGYRgqsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVteT
.|||| ||  |  .||.|  | |  . ||. ||...| .     .| |||.|  |. |.|||| ......|.|   |.|   |||.||.|...|  .  |
kknrykdvvcndktrvil..kdG.ydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl..t

YGDIQVTVRKKVNHN-DYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRrsresfTMPGPAVVHCSAGIGRTGVFIGADIGMREL
.|.| |.  .. ... .  . |. |.. .      . |.    |||  |.    ...  |   |      ...|| |||||||||||| |.  ..|.. |
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr......kasGpvvvhcsaGiGrtGtfvaievglqil

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYV
 . . .|.| .|  .|. | . ||   ||. | .|| .. |  .|.
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyi

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 431-663 3.1e-20 66.8 In-house 50-338 (349) alignment
Range on Protein: 431-663
Range on HMM: 50-338/349.0
EKNRYCDVLPNPNSRVVLFLKF--------------GIANSDYINANFIRGYRG-QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
 |||| |.||   |||.|                  .    ||||||...  |    | ||||| ||| |. ||....  ..  ...  .   | .. ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

NQYWPDTHGYGVT-------ETYGDIQ------VTVRKKVNHNDYTLTTFLVQHLERH--VT---R---EVIHYWYTNWPDMGVPDNPSSVVD------F
..|| .    ..|       .   ..|       ||... |.||        .. . .  ..   .   |..   . ||.|...  || |..        
diywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevknd

LLETRRSRESFTM--PGPAVVHCSAGIGRTGVFIGADIGMRELEETQMI-----------DVLRI-VANMRQDRGGMVQTKDQYVFLHK
|...  .|  .      . .|||||| |||||..  |. .  || .|             |.. | | ..|. |  |||   |......
liddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiye

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 431-578 1.3e-12 41.9 In-house 98-235 (244) alignment
Range on Protein: 431-578
Range on HMM: 98-235/244.0
EKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMtTGLVERNmakcNQYWPDTHGYGVTET
 |||    ||   .|| |    |     |||| |. |  |..  || || ||  |  |||.|. |.   |...  | || .    ..||||.      | 
wknregaglpfdfnrvpl..skgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvv.lgsveee....deywpdseplewyee

ygDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGV
  || ||.  . .  .   . . ..       . .  .  .|||  | 
..ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 433-671 1.2e-28 95.0 In-house 47-273 (288) alignment
Range on Protein: 433-671
Range on HMM: 47-273/288.0
NRYCDVLPNPNSRVVLFlkfgiA-NSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvTETY
.|| ..     .|| |           ||.|| .   .   .  | .| ||  ||  .|.|. |.    |.| . |.|.   | ..|.|   |   .  .
dryenlprcditrvkls.....ddpdfyiaanvvssak.ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe..kari

GDIQVTVRKKVNHNDYTLTTFLVQHLERHVTRE-VIHYWYTNWPDMGVPDNPSSVVDFLLETrrsrESFTMpgPAVVHCSAGIGRTGVFIGADIGMRELE
| .   |.|| .  | ...  |..  .   ..  | .  . .|.| |||.|  | . .|       .|..   | |||.|||.|||| .|   | .. | 
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqk..PivvhssaGvGrtgtlililialeslr

ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
 .  . . ...|..|..|   .||. ||...|....|.   
lddflgirsllaklreerfkaiqtemqylyvhrcvleelll

0044763 (Phosphotyrosine protein) phosphatases II 440-667 2.4e-35 117.2 In-house 1-169 (178) alignment
Range on Protein: 440-667
Range on HMM: 1-169/178.0
PNPNSRVVLFLKFGIANSDYINANFIRGYrgqskAYIATQGPlpftiADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygvtetygdiqvtvr
| ...||.|.   |.  ||||||..| ..      |.....|     ||......|.  |.|.. |. .|..  ||..|||. .|               
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

kkvnhndytlttflvqhlerhvtrevIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMREleetQMiDVLR
                          |.| ....||.|||| .. . .|.   .. ..  . .|| .||||||.||.|... |.. ..     .. ..  
..........................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.slee

IVANMRQDRGgMVQTKDQYVFLHKILYE
... .|. |  .|.. .|. .|...  .
aielvrerRp.ivpnpgqlrqLyefelr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 443-665 1.6e-21 71.7 In-house 32-255 (290) alignment
Range on Protein: 443-665
Range on HMM: 32-255/290.0
NSRVVLFLKFGIANSDYINANFIRGYRGQskAYIATQGPLPF-------TIADFWRMVWEQRTTVIIMTTGLVERNMA----KCNQYWPDTHGYGVteTY
..||||       |.||| ||..    |.  . |.|| |.         || .|| |. . . . ..|.    |..       |..| |.. |  .  ..
atrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel..kf

GDIQVTVRKKVNHNDYTLTTFLVQHlERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResfTmpgPAVVHCSAGIGRTGVFIGADIGMRELE-
....|   .|....|    . .|.. . ..   | |... .| .. |.... .... .   . |.   |   |..|||  || |  ..   ..|.  .  
kgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkask...t...pvivHcvdGiSrsAalaaiilgyQkiae

ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKIL
 .. . .  .. ..|. |  ..... .. |    .
tsgsvkledvlkalrkqralaitsalelafvdagi

0046846 (Phosphotyrosine protein) phosphatases II 455-670 9.8e-45 147.7 In-house 10-174 (176) alignment
Range on Protein: 455-670
Range on HMM: 10-174/176.0
ANSDYINANFIRGYRgqskaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVtetygdiqvtvrkkvnhndytlttflv
 ..||||||.| |.|     .|||||||| |.|||..|..|.. |.... | .|| .. || .|||. ...|.                           
ldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

qhlerhvtreviHYWYTNWPDMGVPDNpSSVVDFLLETRRSRESFtmpGPAVVHCSAGIGRTGVFIGADigmreLEET-QMIDVLRIVANMRQDRG-GMV
            .|....|||.||||  . . ..| . |. ...    || .|||||||||||... |.     | |. . ..|. ..| .|. |  |.|
............qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgav

QTKDQYVFLHKILYEYAK
|| .|| ||.. .... |
qtpeQyrflyefellllk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 455-578 7.6e-11 36.4 In-house 11-126 (130) alignment
Range on Protein: 455-578
Range on HMM: 11-126/130.0
ANSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMtTGLVERNmakcNQYWPDTHGYGVTETygDIQVTVRKKVNHNdYTLTTFLV
 . .||||.|. |  |... |. || ||  |  |||.|. |.   |...  | || .    ..||||.  .   |.  || ||. .. . . .  ...| 
qgntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvv.lgsveee....deywpdsePlewyee..diivtltdrdefk.nikasnle

QHL-ERHVTREVIHYWYTNWPDMGV
 .    .  . .  .  .|||  | 
iesdlneshqaltmfqisnwpsdgt

0051429 (Phosphotyrosine protein) phosphatases II 456-671 2.1e-53 177.0 In-house 3-227 (272) alignment
Range on Protein: 456-671
Range on HMM: 3-227/272.0
NSDYINANFIRGYrGQ---SKAYIATQGPLPFTIADFWRMvWEQRTTVIIMTTGLVERNMAKCNQYWPDT--------HGYGVTETYGDIQVTVRKKVNH
 |.||||... || |.    .......|||| |.|||||. .|.. ..|.. ....||.. || .|||.           .  | .||.. ||. .....
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

NDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPssVVDFLLETRRsresftmPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMID-------
.||.|...|. .|   . .||| |..||.|||.|||...  ....| . ..       .|| .||||||..|||... ... .. .......|       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
 ....|. .|. | |.||| .||.||...| |....
yleeaveelraqrpgavqteeqylflyeallellrs

0043147 (Phosphotyrosine protein) phosphatases II 456-662 1.1e-43 144.2 In-house 4-154 (172) alignment
Range on Protein: 456-662
Range on HMM: 4-154/172.0
NSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLvernmakcnqywpdthgygvtetygdiqvtvrkkvnhndytlttflvQ
.||||||... .|.   . .|||||||..|.||||||..|.  |.|.. |.|                                               .
gsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel...............................................l

HLERHVTREVIHYWYTNWPDMGVPdNPSSVVDFLLETRR--SRESftmPGPAVVHCSAGIGRTGVFIGADIGMreleetQMIDVLRIVANMRQDRGGMVQ
..  ...|..|.|.|..|||.||| ... . .||   ..   ...    || .||||||.||||... |.. .      . .... .|| .|. |.|.||
ydpellerlgiqylylpwpDhgvp.llellleflefidellalsp...ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TKDQYVFLH
...|| ||.
npsqyrfly

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 456-674 1.6e-23 77.9 In-house 66-281 (312) alignment
Range on Protein: 456-674
Range on HMM: 66-281/312.0
NSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGV-------TETYGDIQVTVRKKVNHNDYT
.  || |||..    . . ...|||||  |.. ||...    .| ||. .|.||    || .|  |  |.         ||   .|..  . | .     
enfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrv

LtTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftmpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDR
|   .|.   .     . || .. ||| |.||   .   .|   .. .       | . |||||.|||| ..  .  .  |   .  .|  .   .|.||
l.kvvvkatgq..esklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdr

GGMVQTKDQYVFLHKILYEYAKRIGY
   |..  |||.  ... |.    | 
arsvrvfpqyvyalrcvleflyskgl

subfamily_eak_pd Subfamily eak 456-580 8e-14 45.8 In-house 77-196 (332) alignment
Range on Protein: 456-580
Range on HMM: 77-196/332.0
NSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGyGvTETYGDIQVTVRKKVNHNDYTLTTFLVQ
.  ||||  .  .    . || |  .    .  ||.|| ||..  |..    || .. | ..|.||         .| ..|. .. |..| .    . ..
rlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr.e.elkfGildverkefvkrniletrllels

HleRHVTREVIHYWYTNWPDMGVPD
      | .| || .  | .. .| 
k..GnethrvlhykvfGwtettlpk

0036282 (Phosphotyrosine protein) phosphatases II 457-663 3.2e-46 152.5 In-house 2-164 (174) alignment
Range on Protein: 457-663
Range on HMM: 2-164/174.0
SDYINANFIRGYRGQSkAYIATQGPLPftiadFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgygvtetygdiqvtvrkkvnhndytlttflvqh
||||||... ...  .  .||.||||.     ||.|..|.. |...| . ..|... || .|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

LERHVTREVIHYWYTNWPDMGVPDNPSsVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMRELEeTQMIDVLRIVANMRQDRGGMVQTKD
|  . .|..|.|.|..|||.|||| .  . .|. . .. ...    || .||||||.||||....|.. .| |. . ..|.|..|. .|. |.||||| .
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYVFLHK
|| ||..
Qyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 457-667 6.2e-36 118.6 In-house 3-151 (151) alignment
Range on Protein: 457-667
Range on HMM: 3-151/151.0
SDYINANFIRGYrgqskaYIATQGPLPftiaDFWRMVWEQRTTVIIMTTGLVERNmaKCNQYWPDTHgygvtetygdiqvtvrkkvnhndytlttflvqh
|||||.... |.      .....|||.    ||.....|.  ..|.. ....||.  .| .|.|..                                  
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

lerhvtREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRsresftM-PGPAVVHCSAGIGRTGVFIGADIGMREleetqmIDVLRIVANMRQDRGGMVQTK
      .||.|.....||| |.|... .|..|| . ..      . .|| .||||||.||||....... ..       ...  ... .|. |.|.||..
......ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpn

DQYVFLHKILYE
.|..|... |.|
qqflfqlfalle

0049260 (Phosphotyrosine protein) phosphatases II 471-663 8.5e-39 128.0 In-house 7-144 (152) alignment
Range on Protein: 471-663
Range on HMM: 7-144/152.0
QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWpdthgygvtetygdiqvtvrkkvnhndytlttflvqhlerhvtreviHYWY
.....||||||.| |.||||||..|.  |.|.| | |.|..  ||.||.                                               .| .
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylh

TNWPDMGVPDNPSSVVDFLLETRRSreSFTMPGPAVVHCSAGIGRTGVFIGADIGMreleetQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
..|||.||||..  . ..||  ..        || .||||||.||||... |.. .      . .... .|| .|. | |.|....|. ||..
lpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 471-545 1.8e-09 31.4 In-house 234-302 (440) alignment
Range on Protein: 471-545
Range on HMM: 234-302/440.0
QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLverNMAKCNQYWPDTHgYGVteTYGDIQVTVRKKVNHN
. .|.|||| ||  |. ||||.| . | . |||   |   |   |  |||      |  |.| . |  .   | |
kknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt.rsv..tfgpftvghkgsenmn

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 473-663 2.4e-33 110.0 In-house 5-198 (199) alignment
Range on Protein: 473-663
Range on HMM: 5-198/199.0
KAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH--LERHVTREVIHYWY
. ||||| ||  |.||||.||||  .  |.|       . |    ||| |.    |  || . ||..  . . |||.|....         |||. || .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPDMGVPdNPSSVVDFLLETRRSRESFT--MPGPAVVHCSAGIGRTGVFIGADIGMRELEE--TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
| | .   | | .  | |.. .|     .      | .|||| | | ||||.  |||.|  ||  | ..|.. .   .|| | |.. . ..| |...
tswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 473-663 2.9e-33 109.7 In-house 4-197 (198) alignment
Range on Protein: 473-663
Range on HMM: 4-197/198.0
KAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH--LERHVTREVIHYWY
. ||||| ||  |.||||.||||  .  |.|       . |    ||| |.    |  || . ||..  . . |||.|....         |||. || .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPDMGVPdNPSSVVDFLLETRRSRESFT--MPGPAVVHCSAGIGRTGVFIGADIGMRELEE--TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
| | .   | | .  | |.. .|     .      | .|||| | | ||||.  |||.|  ||  | ..|.. .   .|| | |.. . ..| |...
tswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 476-671 8.4e-20 65.4 In-house 93-287 (302) alignment
Range on Protein: 476-671
Range on HMM: 93-287/302.0
IATQGPLPF---TIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDTHGygVTETYGDIQVTVRKkVNHNDYTLTTFLVQHLERHVTREVIH--YWY
| .| |       ...|||||.... . . .  |  | .    ....| . |    ..||.. | .|| |.. . . | . .  |   ..  |.   |  
ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg..dykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvl

TNWPDMGVPDNPSSVVDFLLETrrSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||..  ||.. ....    .     ..     ..|.    |.|| |.|. . . . .|.. .   .  ||...|..|  .|.. .|||.|. .|  | |
tnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

R
.
k

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 484-660 1e-20 68.9 In-house 39-212 (255) alignment
Range on Protein: 484-660
Range on HMM: 39-212/255.0
FTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKkvNHNDYTLTTF-LVQHLE-RHVTREVIHYWYTNWPDMGVPDN
.|.. |....  ..|.|..| . . | .. ||..|.|  .       . |..||. |  . .|  | |  .. .|  .  |..| || |. |..   |..
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekd..eklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

PSSVVDFLLETRRSResftmpgPAVVHCSAGIGRTGVFIGADIGMR----ELE--ETQMIDVLRIVANMRQDRGGMVQTKDQYVF
.  .   |   | |.       . |||||.||||.  |. |..  .     |.  ||  .| |... ..|. | . ..|  |  |
areilnilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 484-661 2.8e-19 63.7 In-house 102-280 (302) alignment
Range on Protein: 484-661
Range on HMM: 102-280/302.0
FTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVT-ETYG----DIQVTVRKKVNHNDYTLTTFLV--QHLERHVTREVIHYWYTNWPDM
 |.  .| .. . ......  ...|| .  || .|. |  |  ..   |     ...  . .  . ....| |  .  .. ...| . |    .. ||| 
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPDNPSSVVDFLletrRSRESFTMpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFL
| |... . .| |    .  ||.      .||||||.|||| ..    |.    . .. |.| ||  .|| | | ||...| ..|
Gapkeaytaldil....kfcesykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_hpo-7_pd Subfamily hpo-7 484-660 7e-18 59.5 In-house 45-218 (263) alignment
Range on Protein: 484-660
Range on HMM: 45-218/263.0
FTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKkVNHNDYTLTTFLVQHLE-RHVTREVIHYWYTNWPDMGVPDNP
 ||. |....  ..|.|..| .   | .. ||..|.|  .       . ...|.. | | ..    |  |.. |. .  |..| || |. |..   | ..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekd..ekqklanvnvcttk.vqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

SSVVDFLLETRRSREsftmpgpAVVHCSAGIGRTGVFIGADIGMR----ELE--ETQMIDVLRIVANMRQDRGGMVQTKDQYVF
 ...  |  .| |..        |||||.||||.  |  |..  .     |.  .|  .| |... ..|. | . ..|  |  |
reilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 486-671 1.5e-07 24.3 In-house 131-311 (346) alignment
Range on Protein: 486-671
Range on HMM: 131-311/346.0
IADFWRMVWEQR-TTVIIMTTGLVERNMAkCNQYWPDTHGYGVTetyGDIQVTVRKK-V--NHNDYTLTTfLVQHLERHVTREVIHywYTNWPDMGVPDN
. ||| |.....   | .|      .| .    .  .  ||  |   | . .  |.  |  . ..||.   | .     |  .| |  .. |  .  | .
vedfwymiyqeqihlvylmvpddklkntt.tslfndenggyqyt...gkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhh..hapwkhlqqppk

PSSVVDFLlETRRSRESFTMPGPAVVHcSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
   .. ..     | . .   |  ||    | ||.  ||||   ...|..    ... |. |..|.| | |..  ||  .. |...|  |
tlpiikmi.hqflsekqvqnagvcvvs.lfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiar

0048076 (Phosphotyrosine protein) phosphatases II 531-667 8.6e-26 85.7 In-house 13-141 (145) alignment
Range on Protein: 531-667
Range on HMM: 13-141/145.0
YGDIQvTVRKKVNHNDYTLTT-FLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftmPGPAVVHCSAGIGRTGVFIGADIGMRel
.|..  |...  .  |. .|| . . . .. ..|..|.|.|..|||.|||| .. . .||   .. ...   .|| .||||||.||||....|.. ..  
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll..

eetQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
   . ...  ... .|. | |.|.. .|. ||.. ..|
...lgvsleealelvrsqrpgavpnpgqlrflyefele

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 538-667 2.5e-22 73.8 In-house 68-192 (440) alignment
Range on Protein: 538-667
Range on HMM: 68-192/440.0
VRKKVNHNDYTLTTFLVqHLErhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDV
  | | ..||  ....   .|   .| . .| |  ||| |||   . |. .. .   |.|  .  || .|||||| ||||| |  |  .|| . .. ||.
evkgvpdsdyinasyin.gie...srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsdqidi

LRIVANMRQDRGGMVQTKDQYVFLHKILYE
. .. .||..|  |||| .||.|.|. . |
fsfinsmrnnrpqmvqtpeqyafvheavle

0048179 (Phosphotyrosine protein) phosphatases II 542-663 1.6e-23 78.4 In-house 26-139 (144) alignment
Range on Protein: 542-663
Range on HMM: 26-139/144.0
VNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftMPGPAVVHCSAGIGRTGVFIGADIGMreleeT-QmIDVLRI
 ... .|. ..  ..   ...||.|.|....|||.|||| .. . .||   .. .|    .|| .||||||.||||... |.. .     . . ...  .
kklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleea

VANMRQDRGGMVQTKDQYVFLHK
.| .|. | |.|.. .|. ||..
lalvrsrrpgavpnpgqlrfLle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 546-668 2.4e-15 51.1 In-house 201-343 (350) alignment
Range on Protein: 546-668
Range on HMM: 201-343/350.0
DYTLTTFLVQHLERHVtreVIHYWYTNWPDMGVPDNPSSVVDFLL------ETRRSRESF--TMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQ----
 ..||   .   . .|   | .  . ||.|...  || |..  |       ..  ... .      | .||||||.||||...  |  . ..|  .    
nnsltaitlaasdPyv...vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk

----------MIDV-LRIVANMRQDRGGMVQTKDQYVFLHKILYEY
          . |.   || ..|. |  |||..||..|... |  |
esrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy

subfamily_CDKN3_pd Subfamily CDKN3 556-664 8.3e-06 19.5 In-house 90-191 (202) alignment
Range on Protein: 556-664
Range on HMM: 90-191/202.0
HLERHVTREVIHYWYTNWPDMGVPDnPSSVVDFLLETRRSRESFTMpgpAVVHCSAGIGRTGVFIGADIGMreLEetQMIDVLRIVANMRQDRG-GMVQT
.|    ..  .   .   .| .||| ..| ...| | | . ....    ..|||  |.||. . |   . .  |.  ..|.    ....|. .| . .||
rlldlyqqaglivhhypiadglvpd.iasclkileelrinlkayrk...tlvhcygglgrsslviacllly..ld..dtiepkdaidklrdlkgsraiqt

KDQYVFLHKI
  || .|...
vkqynylsef

0038934 (Phosphotyrosine protein) phosphatases II 559-667 9.8e-10 33.9 In-house 73-175 (194) alignment
Range on Protein: 559-667
Range on HMM: 73-175/194.0
RHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMReleetQMIDVLRIVANMRQDRGGMVQTKDQY
.....  |.|    .|| |.. . . . .||    .  .    .|  .||| ||.||||....| . .|     . ...   .| .|. |.|.... |..
eefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyl

VFLHKILYE
  |.|   |
eallkryke

subfamily_PTPDC1_pd Subfamily PTPDC1 559-663 1.8e-07 25.8 In-house 77-170 (182) alignment
Range on Protein: 559-663
Range on HMM: 77-170/182.0
RHVTREVIHYWYtNWPDMGVPdnpssVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMreleeTQMIDVLRIVANMRQDRGGMVQTKDQY
  . .....| .  |.| ||.      .. .|.  .  ..    |   ||| || ||||| | . .       .. ..  . .  .|. |   .||..| 
almeqgiyvynf.gwkDygva.....sleriLdivkvvafalqegkvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqv

VFLHK
 ....
elvke

PTPc_DSPc_SM00012 565-666 4.4e-33 109.0 In-house 2-104 (105) alignment
Range on Protein: 565-666
Range on HMM: 2-104/105.0
VIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRELEET-QMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
| ||.||.|||.|||....|....| .......  .  .| |||||||.||||.|. .|| .. ||.. . .|...||  .|. | |||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ILY
.| 
all

subfamily_CDC14_pd Subfamily CDC14 602-659 2.7e-06 21.4 In-house 263-315 (328) alignment
Range on Protein: 602-659
Range on HMM: 263-315/328.0
PGPAVVHCSAGIGRTGVFIGADIgMRELEetqmIDVLRIVANMRQDRGGMVQTKDQYV
 | ..||| ||.|||| .|.. . |.. .    .    ..| .|  | |.| .. |  
eGaiavhCkaGLGrtGtLiacyl.mkhyr....ftaaeaiawlricrPGsvigpqqkf

subfamily_CG42327_pd Subfamily CG42327 603-672 3.3e-23 76.8 In-house 248-318 (319) alignment
Range on Protein: 603-672
Range on HMM: 248-318/319.0
GPAVVHCSAGIGRTGVFIGADIGMRELEET-QMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
|| ||||| |.||||. | .|| .|.|||. . .|. ..|  .|.||.  |.||.|| |..|.|.|||| .
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 606-669 6.1e-13 43.0 In-house 2-65 (69) alignment
Range on Protein: 606-669
Range on HMM: 2-65/69.0
VVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|||||.| |||| ||   . |  .   ...|..  |  ||. |  ||  . .|.|.|  | |  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 606-669 1.2e-12 42.0 In-house 1-64 (69) alignment
Range on Protein: 606-669
Range on HMM: 1-64/69.0
VVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|||||.| |||| ||   . |  .   ...|..  |  ||. |  ||  ...|.|.|  | |  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal