Gene AquePTP-Un-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP044_AA protein Get Run
AqueP044_AA_405-675 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 396-683 7.8e-50 164.4 In-house 14-250 (392) alignment 
Range on Protein: 396-683
Range on HMM: 14-250/392.0
TELEHCLRYYGSLHDQYMsiPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWE
 .  |.  ... .||     |  .          ..|||| ..||  ..||.| .   |..|||.|| .|...  . |||||.||| . .. ||||||..
eknrhsalffeefhdlpg..pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfq

QRTTVIIMTTGLVERNmakcnqywpdthgygvtetygdiqvtvrkkvnhndytlttflvqhlERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRS
...| |.| | | | .                                                . .| |  . .|.||| .||   ||.. |. | .  
envttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad

RESFTMpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVPRIHGMN
  ..|   | ..|||||.||||| |  |  .   ..|.|.||. .|.|.|. |  |||||.|| |..  . |       ..| .|  .
fGqyth..pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 403-669 3.5e-47 155.6 In-house 12-293 (301) alignment 
Range on Protein: 403-669
Range on HMM: 12-293/301.0
RYYGSLHDQYMSIPANMTSMNEIPSGAQ--EKNRYCDVLPNPNSRVVLFLK--FGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRT
 .  ....|| ..  .    ...    .  . ||. .. . .. |..|  |  . ... .||||..| ||. ..|..||.|||.  |..||||..|....
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekp

TVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQ--------HLERH-------VTREVIHYWYTNWPDMGVPDNPS
. |.| |.| |.  .||.||||...    .|..| ..||. .. .. |...  . |.        ..||.        ...|. .  |.||. ||  .| 
vsivmvtnlkegtkskceqywpnsea..eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

SVVDFLLETrRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 |.  . .    |.     || |||||....|.||..  .||.        .||  ..  .|. . |.|.| .||....... .| 
tvLqviddv.ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 404-669 4.9e-76 250.8 In-house 32-290 (298) alignment 
Range on Protein: 404-669
Range on HMM: 32-290/298.0
YYGSLHDQYMSIPANMTSMNEIPSgAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSkAYIATQGPLPFTIADFWRMVWEQRTTVIIM
 .  |.    .|... ... . |.  ..||||.|...   |||||  . .  .|||||| |. .|.|.. |.||||.||. |..||||||.|.  ..|.|
efqrlnsvsseieeeekevarkpe.nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVm

TTGLVERNMAKCNQYWPDTHgygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRsRESFTMPG
 | |.| .  |...||||..    .||||.|.|....| .. |.. ... |.. ... .||| .  .|.||| ||| | .||.|.| . |.  .. .   
ltnleeldktkyhkywPdeg....ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnk

PAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
| .|.||||.||.| ||  |  .  ... |..||...|  .|..| |.|||..||||....  |. 
pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
0051299 (Phosphotyrosine protein) phosphatases II 406-670 2.6e-91 301.3 In-house 26-287 (288) alignment 
Range on Protein: 406-670
Range on HMM: 26-287/288.0
GSLHDQYMSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTT
   ... .|. ...|    .    .||||| |.||. .|||.|    |. .||||||..|.||. . | .|||||||| |..|||||||||...||.| |
leefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmlt

GLVERNMAKCNQYWPDthgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHL----ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTM
.|||... || ||||.    | ..|||||.|| .. . ..|||..|. |..|      . .|.|.|..||||||.||||.|....||| . |....    
klvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sg

PGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
.|| |||||||.||||.|| .|. .. ||.....|||..|. .|. | ||||| .||.|....|.||.|
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 407-674 6.6e-122 400.9 In-house 6-273 (274) alignment 
Range on Protein: 407-674
Range on HMM: 6-273/274.0
SLHDQYMSIPANMtSMNEIP-SGAQEKNRYCDVLPNPNSRVVLFLKFGIAN-SDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMT
.|.......|.|. ...|.  .|.|.||||...|||.||||.|  . . .. |.|||||.|.||...||||.|||||||.|.||||||.......||.|.
dlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TGLVERNMAKCNQYWPDTHGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMP-G
| | |.|..||..|.||...| ..|.|||....|.|.|..|||.........|||  .|.|.|||||.|||. .||......|..||...|||. ... .
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakla

PAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGY
|.||||||||||||.||...|..|.|.|....|||.||.|.|.||||||||..|| ..|..|..|.||. .
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrlla
subfamily_PTPRA_pd Subfamily PTPRA 408-668 2.3e-77 255.1 In-house 34-294 (330) alignment 
Range on Protein: 408-668
Range on HMM: 34-294/330.0
LHDQYMSIPA-NMTSMNEIPS--GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMT
..... ..|| .. .  |. |    .||||. ..||.  |||.|  | |. .|||||| || ||. . . .||.|||.  |. |||||.|||... |.| 
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk.ekdkfiaaqGPkeetvedfwrmiweqksativml

TGLVERNMAKCNQYWPDThgyGvTETYGDIQVTVRKKVNHNDYTLTTFLVQH----LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFT
| | ||.  ||.|||||    | . |||.|.|.|....  .|||.  ||||.     ... .| |  . .| |||.||| .|  ....| . .. ..  .
telkerkeekcaqywPde...G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa

MpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
   | |||||||.|||| ||  |  .  ..  ...|| ..| ..|. |  ||||. ||.|..|.| ||
g..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 408-669 2.6e-71 235.3 In-house 24-283 (305) alignment 
Range on Protein: 408-669
Range on HMM: 24-283/305.0
LHDQYMSIPANmTSMNE--IPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTT
|  || |.. .  ....    .  ..|||. .. . ...|. |  |    .||||||... ||. ..|.||..||||. |.|||||...| ....|.| |
leaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk.rkkkyivaqgPlkntvadfWrliveekvstivmlt

GLVERNMAKCNQYWPDTHGYgvTETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGP
.||| .  ||.||||.....  .. .|...|... . . .||.   . .    | . .| |..|  |.||| |||. ..|..... . ......     |
klveggkdkCrqYWpeskte..kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvp

AVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 .||||||.|||||||  || .  |.. ...|| ... ..|. | .||||.||||||| .| |. 
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 408-469 8.9e-06 19.3 In-house 24-87 (440) alignment 
Range on Protein: 408-469
Range on HMM: 24-87/440.0
LHDQYMSIPANMTSMNEIPS--GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYR
 .|..  .|. ... ..| |    . |||| ..|   .|||.|    |. .|||||| .| |  
fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
0036941 (Phosphotyrosine protein) phosphatases II 409-677 1.1e-85 282.9 In-house 19-285 (297) alignment 
Range on Protein: 409-677
Range on HMM: 19-285/297.0
HDQYMSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLflkfGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLV
... ... ....    .  . .||||| |.||....||.|    .  .||||||... ||. . | .|||||||| |..|||||||||..|||.| | ||
feellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelv

ERNMAKCNQYWPDThgYGVTETYGDIQVTVRKKVN--HNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAV
|... || ||||..   | . ||||..||...     ..||||.|. |....   .|.| |..||.|||.|||..|.|..||. . |. .. .. .|| .
elgrekcaqywple..egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvl

VHCSAGIGRTGVFIGADIGMRELE---ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVP
||||||.||.|.||.||. .. ||   ... .|.| .|  .|. | |.||| .||.||. .|.|. |.. ...|
VHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 409-668 1.6e-74 245.5 In-house 24-278 (288) alignment 
Range on Protein: 409-668
Range on HMM: 24-278/288.0
HDQYMSIpANMTSMNEI--PSG--AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMT
...| |. |.. . ..    .    ..|||| ..||    || |      |..|||||..| |.... |.||||||||. |. |||..|.|..|. |.| 
seeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivml

TGLVERNMAKCNQYWPDTHgygVTETYGDIQVTVRKKVNHNDYTLTTFLVQhlERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFtmPGP
|.|||..  ||..||||..     . ||...||.... . .|..| ..|..   ..  .|. .| |. |||.|||..   ....|     . ..    ||
telveggktkCeeYWPdad...kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgp

AVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
 .||||||.||||.|| .|  . ..||...|||. .||..|. |  .|||. ||.|....| . 
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_CG42327_pd Subfamily CG42327 409-600 1.7e-52 173.0 In-house 8-198 (319) alignment 
Range on Protein: 409-600
Range on HMM: 8-198/319.0
HDQYMSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLV
 ...  .|  ... .|.| ....|.|. .|.| |..||||  .    .. |..|...|||.     |||.| .|  . .||||.||||.. ||.  | | 
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERNMAKCNQYWPDTHGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYtNWPDMGVPDNPSSVVDFLLETRRSRESFT
|  . .| .|.|   .   |..||||.||....  .. | ..|.|....... .||. |||| .|.. .|| ......  |||.| | .|..
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslksys
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 412-671 1.3e-85 281.7 In-house 1-266 (270) alignment 
Range on Protein: 412-671
Range on HMM: 1-266/270.0
YMSIPANMTSMNEIPSGAQEK--NRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVE
.. .. . || ...|. |..|  ||| |.||.|..||.|       .. |||||..||. |..|.|||..|||| |. .||||.||...| |.|||||.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

RNMAKCNQYWPDTHGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQhlERHVTREVIHYWYTNWPDMGVPDNPS------SVVDFLLETRRSRESFTMPG
..  ||..|||   .  |. ..|.|.|.. ...... | ||   ..  |.  .|...|.||..||| ||| ..       ...  | . |||....   .
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
| .||||||.||||..|  ||..| ||||. .|||.|....|.||  .||. .|| ||.| . |||.|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0047943 (Phosphotyrosine protein) phosphatases II 413-669 1.3e-87 289.0 In-house 22-272 (273) alignment 
Range on Protein: 413-669
Range on HMM: 22-272/273.0
MSIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLflkfGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNM
.|.. ..|    .    ..|||| |.||. .|||.|    |  .||||||....||. . | .|||||||| |..|||||||||...||.| | |||...
lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

AKCNQYWPDTHGYgVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAG
 || ||||.. |  ...|||...||...  ...|||..|. ...|. . .|.|.|..||.|||.|||....|...|. . |. .|..  .|| |||||||
ekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
.||||.|| .|. .. ||.....||| .|. .|. | ||||| .||.||...|.||.
vgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 413-669 7.5e-55 180.8 In-house 18-266 (283) alignment 
Range on Protein: 413-669
Range on HMM: 18-266/283.0
MSIPANMTSMNeIPSGAQEKNRYCDVLPNPNSRVVLFLKFGiansDYINANFIR--GYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVER
.|.|   . ..   .  ..|||. ...|  . || |  .      ||||| ||       |.| ||..|.||  |. |||.||.... | |.| | | | 
lsvpdldadia.sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

NMAKCNQYWPDThGygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHC
.  || ||||   |   .| ||.  ||.|| . .| ..   .|...    . |  . || . .| ..|      |.| | .     .||    || ||||
lrikCsqyWPkr.G...sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkgPivvhC

SAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|.|||||.|||.|   . ..    ..||  .| .||..| ..|||.||| ..|..  | |
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
0050432 (Phosphotyrosine protein) phosphatases II 414-672 1.4e-91 302.3 In-house 53-302 (308) alignment 
Range on Protein: 414-672
Range on HMM: 53-302/308.0
SIPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLflkfGiANSDYINANFIRGYR-GQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNM
|.. ...         ..|||| |.||. .|||.|    .  .||||||....||  ......|||||||| |..|||||||||...||.| | |||...
svkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengr

AKCNQYWPDTHGYgVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftmpGPAVVHCSAG
 || ||||.. |   ...||...||...  ...|||..|. ...|.   .|.| |..||||||.|||..|....||| . |.|...    || |||||||
ekcaqYwplelgg.gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg....gpivVHCsaG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
.||||.|| .|. .. ||.....||. .|. .|. | |||||..||.||...|.||.|..
vGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 415-670 2.3e-75 248.6 In-house 34-284 (319) alignment 
Range on Protein: 415-670
Range on HMM: 34-284/319.0
IPANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAK
.. |.|  .      ..|||| ..|.  ..||||    |. .||||||.|| ||. . ...||||.||  || ||||||||... ...| |.|||.   |
eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvk

CNQYWPDTHgygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHV-TREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGI
...|||...     |.|| . ||. .. . .||    . ....  .| |||| |. ||.||| .||..  |..|.| . |.|||  |  || |||||||.
lkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPivvhCsaGv

GRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||| ||  |. .  ..| ...||  .| ..|  |  |||...|| |....| |...
GRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 416-670 3.9e-85 280.7 In-house 33-281 (318) alignment 
Range on Protein: 416-670
Range on HMM: 33-281/318.0
PANMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
....||.. . .  . |||| ..|.  ..|| |  . |  .|||||||.| ||| ..|||||.|.||| || ||||||||| ..||.| | ..||  ||.
eetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv

NQYWPDTHgygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmPGPAVVHCSAGIGR
..|||.      ...||...|.....|. .||.| .| |.. | . .|.|  | ||.||| |||....|..|.. ....  .. .  || |||||||.||
hryWPskg....srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpivvhCsaGvGr

TGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||||  || .. ... ...||. .| ..|. |  ||||.|||.|....| |. .
tGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 416-670 4.1e-54 178.3 In-house 27-278 (287) alignment 
Range on Protein: 416-670
Range on HMM: 27-278/287.0
PANMTSMNEIPSgaQEKNRYCDVLPNPNSRVVLfLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
.| . . .|. .   .||||.||||  ..||.|  . |   |||||||.. .|. . .|.||.|||.. |. ||||.|.|.|....|. |  ||    ||
tatfkaaeelaa..vkknryadvlPiddtrvll.saegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

NQYWPDTHGYGVTEtyGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRS---RESFTMPGPAVVHCSAG
 .|||. .        |   | . ... . .|.  .. . .|| . .| |  . . .||| ...    ... | |. ..    . . .  || |||...|
ykywPerevPmrvG..GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||.|...   . .. ||..  .|| ..|. .|. | ..||.  |. .| . |  | |
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 416-503 6.6e-10 33.0 In-house 26-115 (347) alignment 
Range on Protein: 416-503
Range on HMM: 26-115/347.0
PANMTSmNEIpSGAQEKNRYCDVLPNPNSRVVLFL---KFGIAN--SDYINANFIRgYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIM
|...|| .|    . .|||  ||  . ..||||     | . |.    ||||  |. .   || || || ||| |. |||.||   . | .. 
pskfts.vew.ekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 417-668 7.1e-37 121.7 In-house 43-288 (305) alignment 
Range on Protein: 417-668
Range on HMM: 43-288/305.0
ANMTSMNEIPSGAQEKNRYCDVlPNPNSRVVLFLKFGiaNSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCN
 ..   |. .  |. |||| || |  .  .|.. |     |||| ||..       | .|..||||  || .|| || ...   |.|    ||    || 
qvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QYWPDTHGYGVTETYGDI--QVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResftmpGPAVVHCSAGIG
|||| ..|  ..   | .  .|.  | .. .     | |        .  | |  .|.||| |||    . ...|   | |.       | |||||||||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk......vpivvhcsagig

RTGVFIGADIGMRELEE-TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
|||  .  .  . .. |  .   .  .|  .|..|   .|.  ||.|.|... .|
rtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 418-670 1.5e-69 229.3 In-house 30-277 (281) alignment 
Range on Protein: 418-670
Range on HMM: 30-277/281.0
NMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQ
. |.        ..|||| ..    ..||..  .    |.|||||||. ||.|. |.|||||||.| ....||.|||||. ..|.| |  .| .  || .
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChr

YWPDTHGygvTETYGDIQVTVRKKVNHNDYTLTTFLVqHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMpGPAVVHCSAGIGRTG
|||| .    . .|||..|.  .. ... |   .| . . |   |||| .  ||.||| |||.... ...|  | .. .|. |   | |.|||||.||||
YWPddns...elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtG

VFIGADIGMRELEE-TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
..|. |  ....|. ....||  .||..|..|  ||||  || |..|.. .. .
tyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 418-672 2.1e-62 205.6 In-house 35-286 (290) alignment 
Range on Protein: 418-672
Range on HMM: 35-286/290.0
NMTSMNEIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIA--NSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
. | . .. |  ...||. ..... . |..|  . |    . .|||| .| ||. . |.|||||||.. |..|||...|....|.|.| |  .| .  ||
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkC

NQYWPDThgyGvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLER-HVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmPGPAVVHCSAGIG
.|||||.   . |..|| ..... .  ..|.|. ... |.. .  . ...|..|  |||.. |   ||....  . |  . .   .  .. |||||...|
qqYWpds...d.tkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvg

RTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
|..||. |....   . .. |||. .. ..|. . |.|||..|| ....|. .| ...
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 419-480 1.9e-07 25.2 In-house 34-95 (95) alignment 
Range on Protein: 419-480
Range on HMM: 34-95/95.0
MTSMNEIPSGAQ----EKNRYCDVLPNPNSRVVLFLKfgiANSDYINANFIRGYRgQSKAYIATQG
|||      |.      |||. ...|   .||||  |    .|||||| |. ||  . ..|||.||
mtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgya.rkncyiaaqg
subfamily_PTPN3_pd Subfamily PTPN3 420-663 2.1e-66 218.7 In-house 33-269 (280) alignment 
Range on Protein: 420-663
Range on HMM: 33-269/280.0
TSMNEIPSGAqEKNRYCDVLPNPNSRVVLFlkfgIANSDYINANFIRGY---RGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCN
.|.   |  . .|||| |.||  . || |      ...||||||..       |... ||||||||. | .|||.|||||....|.| | ||||   || 
isaarkpenl.sknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPDTHGygvTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRT
||||.|.    . .||...|...|. ... | |  ..... | .  |....  |..||| ||||.......|. . |. |..  .  | |||||||||||
qyWPeted...eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrt

GVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
||.|  .. .  .|... . .| || .||. |. .|||..|| |. .
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 420-697 5.1e-63 208.3 In-house 51-318 (319) alignment 
Range on Protein: 420-697
Range on HMM: 51-318/319.0
TSMN--EIPSgAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTglvernMAKCNQ
. ..  ...   ..|||. ..|.  ...| |    |.  |||||| |. ||. . . |||.||||. |.||||||.||.... |.. |        || |
adqtfanldq.nkdknriinilafdknvvklerliGeefsdyinasfvtGyqrk.dkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPDThgygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRT
|||      . ....  .| |    . ..|..  . . .  . .  |..  . .  |||.|||| || .. ..   |  ..    . . |||||||.|||
ywplk....ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYaKRIGYVVPRIHGMNDFEEERYSENDLDD
||.|  |. .  ..| ...|| ..| ..||.|  .||   || |..  | |  . .|.    .  .  . ||. ...|.||
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee.hlfghsdvampdfpayleelsnksdfdd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 420-587 1.8e-09 30.7 In-house 19-163 (169) alignment 
Range on Protein: 420-587
Range on HMM: 19-163/169.0
TSMNEIPsGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINAnfirgyrgqskayiatqgplpftiadfwRMVWEQRTTVIIMTTGLVERnmakcNQYW
  | |.    . ||| .  |   . || |   .    ||||||                            ||.||  ..||..  .  ..     |..|
nfmaelt.cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddk.....nnfw

PDTHGYGV------TETYGDIQVTVRKKVNHNDYT-----LTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVD
|.   | .       | | |       ||. |          ...... ...|| ..  . |. ||. |||..|  |  
pekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvgh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 420-587 2.8e-09 30.0 In-house 18-162 (169) alignment 
Range on Protein: 420-587
Range on HMM: 18-162/169.0
TSMNEIPsGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINAnfirgyrgqskayiatqgplpftiadfwRMVWEQRTTVIIMTTGLVERnmakcNQYW
  | |.    . ||| .  |   . || |   .    ||||||                            ||.||  ..||..  .  ..     |..|
nfmaelt.cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddk.....nnfw

PDTHGYGV------TETYGDIQVTVRKKVNHNDYTLT-----TFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVD
|.   | .       | | |       ||. |   .      ...... ...||...  . |. ||. |||..|  |  
pekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 422-670 2e-39 130.2 In-house 26-260 (267) alignment 
Range on Protein: 422-670
Range on HMM: 26-260/267.0
MNEIPSGAQEKNRYCDVLPNPNSRVVLFLKfgiaNSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMakcNQYWPD
   |..  ||.||. |.||  ..||.|  |    . .|||| .. ||. . .|.|.||.||  ||.||. .. .|. .||.. |   . |.   ...|| 
sqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdni...rlfwPP

THGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQhLERHVTREVIHYWYTNWpDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRTGVFIG
  |   .. | |. |    . . ||| . |. .. ..   ...|  |.| .| .. . ..|     | . ..   |      | ||.||.|.||.| |. 
kmg..qakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw.nintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflv

ADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
.|  .. . . .. |.   . ..|. | |.|.||..|...|..| |||.
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_PTPN14_pd Subfamily PTPN14 423-671 4.2e-59 195.0 In-house 44-298 (300) alignment 
Range on Protein: 423-671
Range on HMM: 44-298/300.0
NEIPSgAQEKNRYCDVLPNPNSRVVLFLKFGIaNSDYINANFIRGY-RGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPD
 . |   .||||. ||||  ..|| |       ...||||  |.    |... ||..||||. |. |||.||||| ...|.| |   |    |. .|.|.
aklpe.naeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

THGYGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFT-------MPGPAVVHCSAGIG
..    | ..|  .|| . . . . .. |.. ..||  .  |.|.|  ||.||| |||..... ...| | .  |. ..       .  | .||||||.|
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
|||| | .|. .  ||  . ||. ...| .|. |  .|||  || |..|.| .| |.
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 423-668 5.6e-43 142.1 In-house 35-276 (307) alignment 
Range on Protein: 423-668
Range on HMM: 35-276/307.0
NEIPSGAQEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDT
 |  |  ..|||| ||    ..|.|.  ||  . |||| ||.. |   . | .|..||||  |. .|| |. ...   .||   ..|    ||.||||  
veafsantdknryqdvkcqdkgrivv..kfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

HGYgvTETYGDIQVT--V----RKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftmpgPAVVHCSAGIGRT
.|   . ..|.   |  |     ||.  ..  .    ..    . .| . |. ..|||| |||.   . ...|  .|  ..      | |||||||.||.
egq..klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn......pvvvhcsaGvGrs

GVFIGADIGM-RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
|  ..  . . . ..     |. ..| ..|..|   .||. ||..||..| ||
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
DSPc_SM00195 424-669 3.9e-82 270.9 In-house 21-262 (263) alignment 
Range on Protein: 424-669
Range on HMM: 21-262/263.0
EIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTH
.. .  ..|||| ..||. ..|| |  . .  .|||||||.|.|.  ..|.||||||||| |..||||||||.....|.|.|  .|..  ||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

gyGVTETYGDIQVTVRKKVNHN-DYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFtmPGPAVVHCSAGIGRTGVFIGA
  | .||.|.|.|..... ... ...|.|. ... ... ||.| .|.|.|||| ||||...||...| . . |...    || |||||||.||||.|. .
..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvti

DIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|| ...|||....|.  || ..|. | |||||..|| |..... ||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 424-669 3.9e-82 270.9 In-house 21-262 (263) alignment 
Range on Protein: 424-669
Range on HMM: 21-262/263.0
EIPSGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTH
.. .  ..|||| ..||. ..|| |  . .  .|||||||.|.|.  ..|.||||||||| |..||||||||.....|.|.|  .|..  ||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

gyGVTETYGDIQVTVRKKVNHN-DYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFtmPGPAVVHCSAGIGRTGVFIGA
  | .||.|.|.|..... ... ...|.|. ... ... ||.| .|.|.|||| ||||...||...| . . |...    || |||||||.||||.|. .
..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvti

DIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|| ...|||....|.  || ..|. | |||||..|| |..... ||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 424-669 2.5e-57 189.1 In-house 42-278 (287) alignment 
Range on Protein: 424-669
Range on HMM: 42-278/287.0
EIPSGAQEKNRYCDVLPNPNSRVVLFlkfgIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTH
.| |  ..|||. ..|.  | ||.|       . ||||| || ||. ..||.|....|.  |. .||....... |.|.| . . | .  .| ||||...
niasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

GygvtETYGDIQVTVRKKVNHNDYTLTTFLVQHLERH-VTREVIHYWYTNWPDMGVPDNPSSVVDFLlETRRSRESFTMPGPAVVHCSAGIGRTGVFIGA
      ..|. .... ..  ...|.  .. |.. ...  ...|  | .|||.. |   .| ...  . | .   .     .. |||||...||...|. |
s....vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.eemyktqrkrgntsivvhCsdtvGrsamfcaa

DIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
...... ..   |||.... ..|. . |.||| .|| |. .|. || 
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_PTPN23_pd Subfamily PTPN23 425-672 3.8e-63 208.0 In-house 39-283 (288) alignment 
Range on Protein: 425-672
Range on HMM: 39-283/288.0
IPSGAQEKNRYCDVLPNPNSRVVLFlkfgIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHG
|     ||||. |.||  ..||.|       . ||||| |...   ..  .||||.||. |..|||.||.||.. ||.| .   |..  |...|||  .|
iaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

ygVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRS--RESFTMPGPAVVHCSAGIGRTGVFIGA
   |...||..||.... . . .   .. ...|. . ...| |  .|.||..|||. |.....|| | . .   .   .  | |||||||.||||||   
..etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DIGMRELEETQ-MIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
   .||||. . ..|....|  .|..|  |||.|.|. |. ..  |.|.|.
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 425-698 1.3e-62 206.9 In-house 22-283 (284) alignment 
Range on Protein: 425-698
Range on HMM: 22-283/284.0
IPSgAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTglvernMAKCNQYWPDThg
..   ..|||. ..|.  ...| |    |.  |||||| || ||. . . ||||||||. |.||||||.||.... |.. |        || ||||    
ldq.nkdknrighilafdknvvklerliGeefsdyinasfitGyqrk.dkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk..

ygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGAD
  . ....  .| |    . ..|..  . . .  . .  |..  . .  |||.|||| || .. ..   |  ..    . . |||||||.|||||.|  |
..ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

IGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYaKRIGYVVPRIHGMNDFEEERYSENDLDDH
. .  ..| ...|| ..| ..||.|  .||   || |..  | |  . .|.    .  .  . ||. .. |.|| 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee.hlfghsdvalpdfpayleelsnksdfddd
0046845 (Phosphotyrosine protein) phosphatases II 427-674 3.5e-90 297.5 In-house 26-279 (284) alignment 
Range on Protein: 427-674
Range on HMM: 26-279/284.0
SGAQEKNRYCDVLPNPNSRVVLFLKFG-IANSDYINANFIRGYR----GQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPD
   ..|||| |.||. .|||.|    | . .||||||....||      ..|..|||||||| |..|||||||||...||.| |.|||... || ||||.
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

ThgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLE-RHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFI
.   | . ||||..||.... ...|||..|. ...|.    .|.|.|..||.|||.|||..|.....|| . |...|..  .|| |||||||.||||.||
e...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

GADIGMRELEETQ---MIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGY
 .|. .. ||...   ..||| .|. .|. | ||||| .||.|....|.||.|.. .
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0045098 (Phosphotyrosine protein) phosphatases II 427-672 6.5e-79 260.5 In-house 31-275 (278) alignment 
Range on Protein: 427-672
Range on HMM: 31-275/278.0
SGAQEKNRYCDVLPNPNSRVVlflkfgiansDYINANFIRGYrgqSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyG
 | ..|||| |.||...|||.          |||||..|.||   .|..|||||||| |.||||||.||...|||.| |.|||... || ||||.    |
lgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe....g

VTETYGDIQVTVRKKVNHNDYTLTTFLVQHL----ERHVTREVIHYWYTNWPDMGVPDNP--SSVVDFLLETRRSRE-----------SFTMPGPAVVHC
 ..||||..||. .  ...||||.|.||..|    |   .|.| |..|..|||.|||..|  .|. ..| . |. ..            .  .|| .|||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGVFIGADIGMRELeEtQMIDVLRIVANMRQDRGG-MVQTKDQYVFLHKILYEYAKRI
|||.||||....|.. .. | | . .|.| .|. .|. |.| .||...||.||.. |.|. .|.
saGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPRG_pd Subfamily PTPRG 427-668 3.9e-74 244.9 In-house 45-286 (563) alignment 
Range on Protein: 427-668
Range on HMM: 45-286/563.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANS-DYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgy
   ..||||.....  .||| |    |. .. ||||||.| ||. .|||.|||||||. |. |||||.|||....|.| | ||||.  ||..|||     
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk....

GVTETYGDIQVTVRKKVNHNDYTLTTFLVQHL--ER----HVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETrrSRESFTMPGPAVVHCSAGIGRTGVF
  .|||| .|||  ..  .  ||  |. ...|  ..    .  ..|..| ||.|||.|||. .  |. |      |.   .  || |||||||.||||..
desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtGty

IGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
|  |  ...... ....|....  .|  |  .|||..||.|||..| | 
ivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Ptp69D_pd Subfamily Ptp69D 427-670 2.4e-68 225.6 In-house 43-287 (307) alignment 
Range on Protein: 427-670
Range on HMM: 43-287/307.0
SG---AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTh
|     . |||| |. .  . ||.|    | ..||||||.||.||. ..| .|| |.|.  || |||||..||  |.|.| . | | | .||..|||.  
sekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.

gygVTETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHV-----TREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRsRESFTmPGPAVVHCSAGIGRTGV
    .  |||| |.. .. .|.||.  .. | . . ..     .|.|. | ||.|.|. ||. . ...... . |   ...   .| ||||||| ||.|.
...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre.lykln.rsPivvhCsaGvgrsgi

FIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|.  |. . .|.. . .|.  .| ..|..|  .||  .|||||.. | .| .
fvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRK_pd Subfamily PTPRK 427-667 6e-66 217.4 In-house 41-275 (314) alignment 
Range on Protein: 427-667
Range on HMM: 41-275/314.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgyg
   .||||. |.|.  .|||.|    | ..||||||..| .|. ...|.|.|||||. |..||||.|...... |.| | |||    || .|||.     
denreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed....

vTETYGDIQVTVRKKVNHNDYTLTTFLVQHLER--HVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRTGVFIGADI
 ||.||||.|.. .   ....   .| |..|.|  . .||| .. ...||| .|| .  ...... .   |.|     |. ||||||| ||||.||  ||
.tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidi

GMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
 .  .|. ...||  .| ..|. .  ||.|..||.|.. .. |
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPRN_pd Subfamily PTPRN 427-665 2.5e-52 172.4 In-house 54-288 (297) alignment 
Range on Protein: 427-665
Range on HMM: 54-288/297.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThGYG
  . .|||. .|||  .||| |  .    .|||||| .|     .. |||||||||. |.||||.||||| ..||.. | | | .. .|..||||. |  
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde.Gse

VTETYgDIQVtVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftMPGPAVVHCSAGIGRTGVFIGADIGM
| . | .... | ...  .|| . .| .. |. . || |  . .  ||..||| .. |...|     .|        | |||||.| |||||.|  |. .
vyhiy.evhl.vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvl

RELE-ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKIL
  |    . ||.   .  .|..| |.|.||||. |  . .
nrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_CG7180_pd Subfamily CG7180 427-668 1.2e-46 153.7 In-house 40-289 (296) alignment 
Range on Protein: 427-668
Range on HMM: 40-289/296.0
SGAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDTHgyg
.  .||||. .|.|  . ||||    | ..|||||| .. ..  . |.|| |..|   |. .|||.|... .  ... |   . .  ....||| .    
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...

vTETYGDIQVTVRKKVNHNDYTLTTFLVQHL----------ERHVTREVIHYWYTNWPD-MGVPDNPSSVVDFLLETRRSRESF---TMPGPAVVHCSAG
  | ||.| | . .. .  . .  || ...           .   || | .. .| |.    ||   .......   |  ||      . || ||..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

IGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
 .|.||....|. .  .|... .|| . |  .|..| ..|.....| ..  .| |.
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0049772 (Phosphotyrosine protein) phosphatases II 427-673 4.7e-46 153.3 In-house 45-284 (314) alignment 
Range on Protein: 427-673
Range on HMM: 45-284/314.0
SGaQEKNRYCDVLPNPnSRVVLfLKFGIANSDYINANFIRGYrgqsKAYIATQGPLPFTIADF----------WRMV--WEQRTTVIIM-----------
 . ..|||| |.|| . .||.|  .... .||||||....|.    ...|||||||. |. ||          ||||  ..... .| |           
ln.rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------TTGLVERNmakcnqywpdthGYGVTETYGDIQvtvrkkvnhndytlttfLVQHLERHVTREVIHYWYTNWPDmGVPDNPSSVVDFLLETR
           ..| ...            .. . ... ...                  ...   ...|..|.|.....|| | .. .. . .||   .
rLdaAlgKtpllildgng............neptaadlellk.................eelydpelferlgikylripvpD.gsaplledfdeflefie

RSresfTMPGPAVVHCSAGIGRTGVFIGADIGMRELeetQMiDVLRIVANMRQDRG-----GMVQTKDQYVFLHKILYEYAKRIG
.       .|| .|||.||.||||.|. |.. |. |   .. ..  ... .|. |      |.... .||.| ...|.|| |.. 
ea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 427-555 3.8e-24 80.1 In-house 43-183 (350) alignment 
Range on Protein: 427-555
Range on HMM: 43-183/350.0
SGAQ--EKNRYCDVLPNPNSRVVLF--------LKFGIANSDYINANFIRGY----RGQSKA-YIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERN
.| .   |||| ..||   ||| |          |  .  .||||||...      . ...  |||||.||| |. ||.... .   .||.. | .|| |
eGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

MAKCNQYWPDThgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQ
. ||..||..    .. .    .. . .. .. || .| .. |.
lekcyrYWqeg...sydditvklaskwenimgindsslysadvk
subfamily_PTPRB_pd Subfamily PTPRB 428-670 1.1e-83 275.7 In-house 50-286 (293) alignment 
Range on Protein: 428-670
Range on HMM: 50-286/293.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHgygV
  ..|||| ..||  .||| |    . ..|||||||.|.||. . . .|||||||| |. ||||||||.....|.| | |||.   ||..|||...    
vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade...e

TETYGDIQVTVRKKVNHNDYTLTTFLVQHleRHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMR
. .||||.||. .. . .|... ......  .. .|.| .| .| ||| |||.......||. . |.. |. .  .| |||||||.||||.||  |  ..
pvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllq

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
..||....|.. |||..|..|  .|||..||.|.|. . .. .
aieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN9_pd Subfamily PTPN9 428-671 8.4e-80 263.0 In-house 41-292 (297) alignment 
Range on Protein: 428-671
Range on HMM: 41-292/297.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygV
.  ||||| |||   ..||||  . .  .||||||||. ||. | ||.|||||||. |. |||||||||.. ||.||| .|||   ||.||||....   
anleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee..s

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRES----------FTMPG-PAVVHCSAGIGRT
.. .||..|.. . ....||. ... ... . . .|.|.|. .. ||| |||.. .|..|.| . |. . .          . . | | |||||||||||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
| ||  || . .|||....||   |  .|. |  ..|| .||.| .. . |||..
Gtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 428-667 7.6e-64 210.6 In-house 48-277 (315) alignment 
Range on Protein: 428-667
Range on HMM: 48-277/315.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgygv
  ..|||| ....  .||| | |     .|||.||||| ||  . . |||.|||.. .. ||||.|.|.  . |.| |.|||..  |...||||      
enkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmpGPAVVHCSAGIGRTGVFIGADIGMR
  .|| | || ...  ...||  |. |   ..   |||. . || |||||||    .....    .. ...    |. |||||||.|||| ||  |  . 
kviyGkitvtrkseevnteytvrtlsvvfgdn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavld

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
..|  ..||| ... ..|| | .|||. .|| |....| |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 428-686 1e-61 203.5 In-house 43-294 (315) alignment 
Range on Protein: 428-686
Range on HMM: 43-294/315.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGV
  ..|||| ..||  ..||.| .   . .|||||| .|...  . |||||.||||. .. ||||||.....| |.| | . | .  ||.||||| ..  |
infkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

teTYGDIQVTVRKKVNHNDYTLTTFLVQHleRHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMpgPAVVHCSAGIGRTGVFIGADIGMR
   .| |.|.. .     | .   . ...   . .| |  . .|.||| ||. . ||.. .. | . .... .   . .||||||.|||||.| .|  . 
..efGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef..sllvhcsaGvGrtGvvisidevva

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVPRIHGMNDFE
....|...||...| |.|..|  .|||...| |.. .. |. .    ... ||  . ..
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 428-664 1.6e-39 130.5 In-house 32-290 (297) alignment 
Range on Protein: 428-664
Range on HMM: 32-290/297.0
GAQEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRG-QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYG
..  |||| |.|   ..|| |  . .|...|||||...      .   || .||||  |. |||..|.||   ||.| . | |    ||  |||.. . .
sslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VTEtyGDIQVTVRKKV--NHNDYTLTTflVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDF----------------LLE-----TRRSRESF----
 .   ||. |    ..  ...   ||   .| . |  .| | |  . .||| ||| .   .| |                |.|          ||.    
lka..gdvvveflsstsdefdrvilte..lqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

TMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKI
  . . .||||||.||.|| . .|. .  |   .. ||  |.  .|. |  .||| .|. .|...
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_egg_pd Subfamily egg 428-673 8.7e-27 88.6 In-house 39-275 (307) alignment 
Range on Protein: 428-673
Range on HMM: 39-275/307.0
GAQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERnmAKCNQYWPDTHGYGV
  .|| |   |  .  ||| | |. |    |.| || ..|       .| .| ||  |  ||||||....   |.| |  .|    .|. ||| ..   .
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVdflletRRSRESFTmpgPAVVHCSAGIGRTGVFIGADIGMR
    | ....  |  .. |  ..   .. .  .     . .|  ..  ..    |  |.      |. |.  .   |.||..  |. ...... ..| . 
vtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl......rklrnlsk...pvvvqdilGvskaatlvaieiall

ELEE--TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY-EYAKRIG
.|    .    ||| |  .|. |   |..  .|.|.....   .   ||
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvig
subfamily_PTPRD_pd Subfamily PTPRD 429-670 1e-95 316.5 In-house 48-282 (564) alignment 
Range on Protein: 429-670
Range on HMM: 48-282/564.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgyGvT
 ..|||| ....  .|||||    |  .||||||.|| ||| ..||||||||||. ||.|||||||||....|.| | |.|..  ||..|||..   | |
NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek...g.t

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMRE
||||...||. .... .||...|| ... ... .||| .. .|.||| |||... |..|.. . |...|  .  || |||||||.||||.||  |. .. 
etygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamler

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
..| ...|.  .|...|..|  ||||..||.|.|....|. .
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0045450 (Phosphotyrosine protein) phosphatases II 429-669 1.1e-82 273.5 In-house 55-304 (307) alignment 
Range on Protein: 429-669
Range on HMM: 55-304/307.0
AQEKNRYCDVLPNPNSRVVLFLKFGI-ANSDYINANFI--------RGYRGqSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYW
 ..|||| |.||....||.|    |   .||||||...         ||.  ....|||||||| |..|||||.|||..|||.| |.|||..  || |||
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PDThgyGVTETYGDIQVTVRKKVNHNDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGV
||.   | . |||...||....  ...||..|. |..| . . .|.|.|..||.|||.|||.......||. | |. .|. . .|| .||||||.||||.
Pde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGt

FIGADIGMRELEETQM---IDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
||.|.. .| ||....   .|.| .|. .|. |.|.||. .||.||...|.|. 
fiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 429-669 2.2e-82 272.0 In-house 45-277 (278) alignment 
Range on Protein: 429-669
Range on HMM: 45-277/278.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPdthgyGVT
 ..|||| |.||...|||.| |  |  .||||||... ||. . | .|||||||| |..||||||||...|.|.| |.|||... || ||||     | .
nkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggs

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMRE
.||||..||..|   ..|||..|. | .|  . .|.| ||.|..|||.|||...|...||| . |. .|  . .|| .||||||.||||.||.... .. 
ltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleq

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|| .. .|.. .|. .|. |.|.||| .||.||...|.|| 
lekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 429-670 7.4e-74 243.1 In-house 9-243 (250) alignment 
Range on Protein: 429-670
Range on HMM: 9-243/250.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAkCNQYWPDTHgygvT
 .||||| |...  .|||||. . |  .|||||| |. ||... ||.|||||||. || ||||||.|. ...|.| | |.| .   ..||||  .    .
nkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek....a

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMRE
|.|||..|.. .| .. ||| ... . . ..   | | .. ...||| |||..  .|...| . ..|..  .  .| .|.||||.||.| ||  |  .  
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavler

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|.. ...|| ...  .|.|| ..|....||||...|. .. .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN12_pd Subfamily PTPN12 429-671 1.3e-71 235.8 In-house 40-279 (290) alignment 
Range on Protein: 429-671
Range on HMM: 40-279/290.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvT
 ..|||| |.||  .|||.|  . .  .|||||||||.|  |. ..|||.||||| |. |||||.||.......|   .|| .  ||..|||....   .
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee..e

ETYGDIQVTVRKKVNH-NDYTLTTFLVQHLerHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMR
 ..|...||. .. .  .|... |. |..   . .|.|  . ||.||| ||| ...|..... . |. .|  .   | |||||||.||||. |  |.  .
lefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvre

ELEETQM---IDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
 |.. ..   .||  .|...|..|  .||||.||....| . |. ..
llkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPN13_pd Subfamily PTPN13 429-669 1.5e-66 219.5 In-house 37-269 (273) alignment 
Range on Protein: 429-669
Range on HMM: 37-269/273.0
AQEKNRYCDVLPNPNSRVVLFlkfgiANSDYINANFIRGYRGQSK-AYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGV
 ..|||| .|||  ..|| |      ... ||||..|.   |. .  |||.||||| |..|||.|||||...||.| |  .|..  ||..|||....  .
nkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

TeTYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftMPGPAVVHCSAGIGRTGVFIGADIGMR
.  .. ..|.. | ........ .. |...|   .||| |  ...||| ||| .. ... |. | || ..     || ||||||||||.|..|  |. . 
k.vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidvvlg

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 .|  . .||  || ..|. | |.|||||||.| .|.. |  
lierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN1_pd Subfamily PTPN1 429-671 2.2e-63 208.7 In-house 32-273 (290) alignment 
Range on Protein: 429-671
Range on HMM: 32-273/290.0
AQEKNRYCDVLPNPNSRVVLflkfGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHG-YGV
 ...||| || |   ||..|      |. |||||...   .   . || |||||| |.. ||.|||||..  ..|   .||... || ||||  .    .
nrnlnryrdvspydhsrikl....eradndyinaslvelee.akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMR
.     ..|.. .. ... ||. .. .. |. . |||..|. || |||.|||. |.. ..|| . |.|    .  ||||.||||||||.| |. .|  . 
lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

ELEETQM---IDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
..|...    .|. . . ..|. | |..||.||  | .  . | || 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 429-669 2.8e-57 189.3 In-house 48-288 (325) alignment 
Range on Protein: 429-669
Range on HMM: 48-288/325.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLvERNMAKCNQYWPDTHGygVT
 ..|||. .|..  .|||||  |   ..||||||...| .... . ..|.| ||. || |.||.| . |..|....  | . .  .| .|||.  |   .
nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemg..ks

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTM----PGPAVVHCSAGIGRTGVFIGADI
 |.| ..| .|   .  ||    . |.  ..  || |  . .  |.||||.  |.... .|       |  |      .| .||||||.|||||||    
ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislys

GMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
 . .. |   .|..  | ..|.||  ||.| |||..... | |. 
alakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 429-667 1.2e-52 173.8 In-house 48-277 (439) alignment 
Range on Protein: 429-667
Range on HMM: 48-277/439.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMakcnqYWPDTHgygvT
 | |||| || .   .||.|    |.  | |||||.|.||  . | |||||||   |  ||||.|.|..|. |.| | |||        |||        
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda....e

ETYGDIQVTVRKKVNHNDYTLTTFLVQHL--ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSrESFTMPGPAVVHCSAGIGRTGVFIGADIGM
  |||| | | ....  .|..  | |       .  | |... |. |||  || . | |.|||     . .     || |||||||.||||  |  || .
vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa.ndkeeygpvvvhcsagvGrtGtiialdial

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
 .|   . .|.  ||  .|..|  |||.  ||||... . |
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 429-671 1.1e-39 130.9 In-house 48-289 (305) alignment 
Range on Protein: 429-671
Range on HMM: 48-289/305.0
AQEKNRYCDVLPNPNSRVVLflkFGIANSDYINANFIRGyRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVT
 ..|||| ||    | || |    |    .|| ||..     ..| .| || ||  | |||| | ....   |.|   |.|.   || .|..  ..  ..
eagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

ETYGDIQVTVRK----KVNHND----YTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResftmpGPAVVHCSAGIGRTGVFI
   .. ...|.     ... ..        | ||     . .| | || . .||| |||    .....| ..| |.      || ||||||||||||  .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvv

GADIGMRELEETQMID-VLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
  .  . .| . |.|.   .|.  .|..|   .|| .||.|.|... .| ..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 429-669 3.5e-38 125.9 In-house 37-269 (281) alignment 
Range on Protein: 429-669
Range on HMM: 37-269/281.0
AQEKNRYCDVLPNPNSRVVLFLKFGIANS-DYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygV
 ..|||| ..     ||| | .|.   || ||| ||.||      . || ||||   | ||||||.|.. || |.|   ..| |  || .|.|      .
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah..c

TETYGDIQVTVRKKvNHNDYTLTTFLVQHLERhVTREVIHYWYTNWPDMGVPDNpSSVVDFLLETRRSRESftmpgPAVVHCSAGIGRTGVFIGADIGMR
   .  . |.       |   .|| |    |   || . |. . .|||  ||.  | |.  .|   |.| .     | |.|||||.||.| ..  .| ..
clqfdklsvsyeds.tvnkslvttrlnlsyeg.etrlithwlwkewpdwqvpes.sevmlkilrkirarst.....ppvihcsagvgrsgtlmaveialq

ELEET-QMIDVLRIVANMRQ-DRGGMVQTKDQYVFLHKILYEYA
 .     . |. .||. .|   |   ||| .||... |.| .. 
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 429-673 9.7e-35 114.9 In-house 35-274 (285) alignment 
Range on Protein: 429-673
Range on HMM: 35-274/285.0
AQEKNRYCDVLPNPNSRVVLflKfgIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVT
  . |||.||    ..||||  |    . ||| |...|    .  .||.|||||| |..|||.|..... . ..|   |.|  . ||  |.|.  |  | 
npdlnryadvrcieetrvvl..k..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

ETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTRE--VIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResfTMPGPAVVHCSAGIGRTGVFIGADIGM
    .| .|  |.       | .. |   |   .    . |     |||   |..   ....    ..         | .||||||.|||  |.| |   
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagvgrtatfvgidyat

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIG
  . |   |..| || .||  |   ||.. |..||. .| ||    |
irimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg
0040438 (Phosphotyrosine protein) phosphatases II 430-677 6.1e-86 283.9 In-house 44-284 (317) alignment 
Range on Protein: 430-677
Range on HMM: 44-284/317.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyGVTE
..|||| |.||...|||.|    |. .||||||... |.. . | .|||||||| |..|||||||||..|||.| | |.|..  || ||||.    | | 
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl....getl

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMREL
||||..||... . ....||.|. |..|.   .|.| |..||.|||.|||..|....||| . |...|    .|| .||||||.||||.||.|.. .. |
tygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleql

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVP
|... .||  .|. .|. |.|.||| .||.||...|.|| || .. .|
ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep
0039614 (Phosphotyrosine protein) phosphatases II 430-672 4.8e-85 280.9 In-house 57-292 (297) alignment 
Range on Protein: 430-672
Range on HMM: 57-292/297.0
QEKNRYCDVLPNPNSRVVLFLKFGI-ANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDTHGygvt
..|||| |.||...|||.|  . |   .||||||... ||.  ....|||||||| |..|||||||||..|||.| | |||... || ||||.. |    
kdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....

eTYGDIQVTVRKKVNHNDYTLTTFLVQHleRHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRE
 ||||..||..|   ...||..|. |..     .|.| |..||.|||.|||...... .|| . |. ...   .|| .||||||.||||.||.|.. .. 
.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
||... .||| .|. .|. |.|.||| .||.||...|.|. ||.
lekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0040439 (Phosphotyrosine protein) phosphatases II 430-669 3.1e-79 261.4 In-house 12-246 (249) alignment 
Range on Protein: 430-669
Range on HMM: 12-246/249.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyGVTE
..|||| |.||...|||.|    |   ||||||..| ||. . . .|||||||| |..|||||.||.. |||.| | |||... || ||||.    | . 
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....ggsl

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMREL
.|||..||...   ..|||..|. ...|.   .|.| |..||.|||.|||.......||. . |  .|.   .|| .||||||.||||.||.|.. .. |
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|... .|.. .|. .|. |.|.||. .||.||...|.|. 
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 430-666 3.2e-79 261.0 Pfam-A 2-234 (235) alignment 
Range on Protein: 430-666
Range on HMM: 2-234/235.0
QEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvTE
..|||| |.||  ..|| |  |    .|||||||...||. ..|..|||||||. ||.|||||||.....||.| | |.|..  ||.||||.. .   ..
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sl

TYGDIQVTVR-KKV-NHNDYTLTTFLVQHLERH-VTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResFTMPGPAVVHCSAGIGRTGVFIGADIGM
|||||.|... |.  ....|||... ... ...  .||| ...|||||| |||..|.|..|.. . ..|.   .  || |||||||.||||.|. .|| .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
..||... .||| || ..|. | ||||. .||.||.|.. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 430-666 3.2e-79 261.0 In-house 2-234 (235) alignment 
Range on Protein: 430-666
Range on HMM: 2-234/235.0
QEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvTE
..|||| |.||  ..|| |  |    .|||||||...||. ..|..|||||||. ||.|||||||.....||.| | |.|..  ||.||||.. .   ..
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sl

TYGDIQVTVR-KKV-NHNDYTLTTFLVQHLERH-VTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResFTMPGPAVVHCSAGIGRTGVFIGADIGM
|||||.|... |.  ....|||... ... ...  .||| ...|||||| |||..|.|..|.. . ..|.   .  || |||||||.||||.|. .|| .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

RELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
..||... .||| || ..|. | ||||. .||.||.|.. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0042113 (Phosphotyrosine protein) phosphatases II 430-669 8.9e-79 259.6 In-house 10-243 (245) alignment 
Range on Protein: 430-669
Range on HMM: 10-243/245.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgyGVTE
..|||| |.||....||.|    |   ||||||... |||   | .|||||||| |..|||||.||.. |.|.| | ..|... || ||||.    | . 
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....gesl

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMREL
||||..||...  ...|||..|. |..|  . .||||||.|..|||.||||......||| . |. ... . .|| .||||||.||||.||.|.. .. |
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleql

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|... ...  .|. .|. |.|.||| .||.||...|.|. 
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 430-671 1.5e-75 249.0 In-house 55-299 (306) alignment 
Range on Protein: 430-671
Range on HMM: 55-299/306.0
QEKNRYCDVLPNPNSRVVLFlKFGIANSDYINANFIR-GYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHgygVT
.|||||  .||  ..||.|  . ....|||||||.|.   .|..|.|||||| |. |..|||||||.. ..||.|||  |||.  || .||||..    .
keknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee...ek

ETYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFT--MPGPAVVHCSAGIGRTGVFIGADIG
|.||.|.||  .. ...||.| ...|..  . . .|||..| ...||| ||| .|. |.||| . .| .|...   .|| |||||||||||| ||  || 
eeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

MRELEETQ---MIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
.. .|..     ||. ..|  .|. | |.|||..|| |..|.. .| ..
lkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0037934 (Phosphotyrosine protein) phosphatases II 430-668 5.2e-72 237.6 In-house 11-241 (243) alignment 
Range on Protein: 430-668
Range on HMM: 11-241/243.0
QEKNRYCDVLPNPNSRVVLflkfgiANSDYINANFIRGYRgqsKaYIATQGPLPFTIAD----FWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPdthgY
..||||.|.||...|||.|       .|||||||.|....   . .|||||||| |..|    ||||.||...|||.| | |||... || ||||     
lsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....g

-GvteTYGDIQVTVRKKVNHNDYTLTTFLVQHLE-RHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRES------FTMPGPAVVHCSAGIGRTG
     ||||..||. .  ...|||..|.|...|.  ..||.||||.|..|||.||||.|....||| |.|   |.          || .||||||.||||
ev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

VFIGADIGMRELeetQmIDVLRIVANMRQDRGG-MVQTKDQYVFLHKILYEY
..| |.. .. |   . .|.. .|. .|. |.| .||| .||.||...|.|.
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 430-666 2e-64 212.1 In-house 4-236 (237) alignment 
Range on Protein: 430-666
Range on HMM: 4-236/237.0
QEKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygvTE
. |||| ..     |||||  |   ..||||||....|. |  | |||.||||  .  |||.|||... .||.| |||.|.|  || .|||.|.     .
kiknrygnivaydhsrvvl..kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq...pa

TYGDIQVTVRKKVNHNDYTLTTFLVQH-LERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRE
.|| . |...|| .  |||. ..|... |. .  | .  | .| ||| |||.. .... |  .     .  .  || ..|||||.||||.|.  |  .|.
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
 .| ...|.   | .. .||  ..||||||||.|. . 
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 430-686 4.8e-62 204.7 In-house 44-293 (515) alignment 
Range on Protein: 430-686
Range on HMM: 44-293/515.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVte
 .|||| ..||  ..|| | .     .|||.|| .|...    |||||.|||.. .. ||||.|.....| |.| | | | .  || .||||  |  |  
fkknryknilPydsvrvklevindnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv..

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTmpGPAVVHCSAGIGRTGVFIGADIGMREL
 .| |.| .       . .  .. | . .   .| |  . .|.||| ||| . ||.. .. | . ... .|   | ..|||||.|||||.| .|  . . 
kfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvaha

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVPRIHGMNDFE
..|.|.||...| |.||.|  .|||..|| |.. .. |. .    ..| ||  . ..
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 430-666 6.8e-61 200.4 In-house 8-237 (239) alignment 
Range on Protein: 430-666
Range on HMM: 8-237/239.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgygvTE
. ||||....    |||||        ||||||...| | |  |||||||| .  .  |||||.|..|  ||.| |||.|    || |||||.     | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....ts

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDflLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMREL
 | ...||.||     || . ||.. .. .   | | .| .| ||| |||.  ..|.   |  . ...|.    | |.|||||.|||| |.  |  .|. 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg..lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILY
.. . .|..  |  .|.||  |||| .||||.|  . 
kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 430-665 7.8e-61 200.3 In-house 9-237 (239) alignment 
Range on Protein: 430-665
Range on HMM: 9-237/239.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDThgygvTE
. ||||....    |||||        ||||||...| | |  |||||||| .  .  |||||.|..|  ||.| |||.|    || |||||.     | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....ts

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDflLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMREL
 | ...||.||     || . ||.. .. .   | | .| .| ||| |||.  ..|.   |  . ...|.    | |.|||||.|||| |.  |  .|. 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg..lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKIL
.. . .|..  |  .|.||  |||| .||||.|  .
kkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 430-668 1.8e-59 196.3 In-house 52-283 (297) alignment 
Range on Protein: 430-668
Range on HMM: 52-283/297.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYRGqskAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDThgyGvTE
 ||.|| ..||   ||| |       .|||.|| |..|..     .|.|| | . |.||||.||.......|.| . . ||.  || .||.|.   | . 
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk...g.vt

TYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPD--NPSSVVDFLLETRRSRESFTMPgPAVVHCSAGIGRTGVFIGADIGMR
|.||. |..    . . .   .. |.. .  ..| |  | ...|||  |.   . ||..... | | . .. .   | .|||.||.|||||..  |  . 
tfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvva

ELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEY
| .... .|.. .|  .||.|  .||||.|| |..... |.
eakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 430-670 8e-39 128.0 In-house 53-291 (310) alignment 
Range on Protein: 430-670
Range on HMM: 53-291/310.0
QEKNRYCDVLPNPNSRVVLFLKFGiANSDYINANFIRGYRGQsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgYGVTE
  ||||.||.   .||| | .       ||| ||...    . ...| .||||  || |||||....|.  |..    .|    ||  |||     ||||
mhknrysdvvcldtsrvklkidks.ryedyihanyvktnylr.stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps...lgvte

TYGDIQVTVRKKVNhNDYTLTTFLVQHLERHVT-------R---EVIHYWYTNWPDMGVPDNPSSVVDFLLETR-RSresftmpGPAVVHCSAGIGRTGV
||| |.||   .   ... .  . |  .   |             |    . ||||.||||.    |   | .. |        || |||||||..|..|
tygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdrlyv

FIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
 .  .. .  |.. . .|.  ........|   .||. ||......   .|.
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_ptpA1_pd Subfamily ptpA1 430-630 3.7e-38 126.4 In-house 48-257 (418) alignment 
Range on Protein: 430-630
Range on HMM: 48-257/418.0
QEKNRYCDVLPNPNSRVVLFLKFGIANSDYINANFIRGYrgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHG-----
  |||| ..||   .|| |        |||||||.| |     | .|.|||||| |||||||||||.|  .|.| .   |    ||..|||.  |     
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

-YGV-TETYGDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDfLLETRRSRESFTMP-----GPAVVHCSAGIGRTG
 ||   | .|   | . . ..  .  . |  ..      ||.. .| |  |||  .||    . . || .   |.   .|      | .||||||.||||
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrq.llhsitnrqnqiipssdrnvpiivhcsagvgrtg

VFIGADIGMRELE
 |  | | |..|.
tfctavimmkkld
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 430-661 3.4e-35 116.2 In-house 51-273 (301) alignment 
Range on Protein: 430-661
Range on HMM: 51-273/301.0
QEKNRYCDVLPNPNSRVVLfLKFGiaNSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVTE
..|.||  |  .|.. | . .. |  .   | ||.|    |... .|||||||. |  ||| |.       |.| .  ||... ||..| | . .  .  
kdkhryptvPckPstavev.ivdG..krvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

TYGDIQVTVRKKVNHNDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftmpgPAVVHCSAGIGRTGVFIGADIGMRE
   .|... .... ... .  |. |.   ..  || |.|| |..|.| |||     . |..   ..|..      | ||||||||||.  |||...  ||
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylare

LEETQMIDVLRIVANMRQDRGGMVQTKDQYVFL
.|  . |.. . ....|..|   |||. |  ..
veadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 430-675 7.4e-20 65.8 In-house 48-285 (303) alignment 
Range on Protein: 430-675
Range on HMM: 48-285/303.0
QEKNRYCDVLPNPNSRVVLflkfgiANSDYINANFIRgYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVTE
 .|||..||.    |.| |      ..| || |...      ||  | || ||. | ||||.|. ||.  ....     | .    .  .|    .   |
mdknrfvdvicldhskvkl......sdssyihasyle.l.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

TYgDIQVTVRKKVNHND-YTLTTFLVQHLERHVTREVIHywYTNWPDMGVPDN-PSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMR
    |.|   |.|.  | ..|    |   . .    | |  | .||   .| .  . .|  . . .     ..   |.|    .| ||.| |   .    
er.sirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

EL-EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYV
 | .|   .|... . |.|. |   ||   |. ... .| |.    |..
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngic
0041856 (Phosphotyrosine protein) phosphatases II 431-675 1.3e-51 170.1 In-house 3-177 (182) alignment 
Range on Protein: 431-675
Range on HMM: 3-177/182.0
EKNRYCDVLPNPNSRvvlflkfgiaNSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTglvernmakCNQYWPdthgygvtet
.|||| |.||...||          ..||||||...|.. ... .|||||||. |.|||.||..|.. |.|.. |         . .|||          
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

ygdiqvtvrkkvnhndytlttflvqhleRHVTREVIHYWYTNWPDMGVPDnPSSVVDFLLETRRsresftMPGPAVVHCSAGIGRTGVFIGADIGMREle
                             ...|..|.|.|..|||.|||| .....||. | ..       .|| .||||||.||||....|.. ..   
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl..

etqMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYV
    ...  .|. .|. | |||.| .||.||. .|.|. ..  ..
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 431-675 6.7e-49 161.1 In-house 58-289 (290) alignment 
Range on Protein: 431-675
Range on HMM: 58-289/290.0
EKNRYCDVLPNPNSRVVLflKFGiANSDYINANFIRGYRgqsKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVteT
.|||| ||  |  .||.|  | |  . ||. ||...| .     .| |||.|  |. |.|||| ......|.|   |.|   |||.||.|...|  .  |
kknrykdvvcndktrvil..kdG.ydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl..t

YGDIQVTVRKKVNHN-DYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRrsresfTMPGPAVVHCSAGIGRTGVFIGADIGMREL
.|.| |.  .. ... .  . |. |.. .      . |.    |||  |.    ...  |   |      ...|| |||||||||||| |.  ..|.. |
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr......kasGpvvvhcsaGiGrtGtfvaievglqil

EETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYV
 . . .|.| .|  .|. | . ||   ||. | .|| .. |  .|.
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 431-663 3.1e-20 66.8 In-house 50-338 (349) alignment 
Range on Protein: 431-663
Range on HMM: 50-338/349.0
EKNRYCDVLPNPNSRVVLFLKF--------------GIANSDYINANFIRGYRG-QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKC
 |||| |.||   |||.|                  .    ||||||...  |    | ||||| ||| |. ||....  ..  ...  .   | .. ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

NQYWPDTHGYGVT-------ETYGDIQ------VTVRKKVNHNDYTLTTFLVQHLERH--VT---R---EVIHYWYTNWPDMGVPDNPSSVVD------F
..|| .    ..|       .   ..|       ||... |.||        .. . .  ..   .   |..   . ||.|...  || |..        
diywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevknd

LLETRRSRESFTM--PGPAVVHCSAGIGRTGVFIGADIGMRELEETQMI-----------DVLRI-VANMRQDRGGMVQTKDQYVFLHK
|...  .|  .      . .|||||| |||||..  |. .  || .|             |.. | | ..|. |  |||   |......
liddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiye
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 431-578 1.3e-12 41.9 In-house 98-235 (244) alignment 
Range on Protein: 431-578
Range on HMM: 98-235/244.0
EKNRYCDVLPNPNSRVVLflKFGIANSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMtTGLVERNmakcNQYWPDTHGYGVTET
 |||    ||   .|| |    |     |||| |. |  |..  || || ||  |  |||.|. |.   |...  | || .    ..||||.      | 
wknregaglpfdfnrvpl..skgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvv.lgsveee....deywpdseplewyee

ygDIQVTVRKKVNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGV
  || ||.  . .  .   . . ..       . .  .  .|||  | 
..ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 433-671 1.2e-28 95.0 In-house 47-273 (288) alignment 
Range on Protein: 433-671
Range on HMM: 47-273/288.0
NRYCDVLPNPNSRVVLFlkfgiA-NSDYINANFIRGYRgQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYgvTETY
.|| ..     .|| |           ||.|| .   .   .  | .| ||  ||  .|.|. |.    |.| . |.|.   | ..|.|   |   .  .
dryenlprcditrvkls.....ddpdfyiaanvvssak.ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe..kari

GDIQVTVRKKVNHNDYTLTTFLVQHLERHVTRE-VIHYWYTNWPDMGVPDNPSSVVDFLLETrrsrESFTMpgPAVVHCSAGIGRTGVFIGADIGMRELE
| .   |.|| .  | ...  |..  .   ..  | .  . .|.| |||.|  | . .|       .|..   | |||.|||.|||| .|   | .. | 
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqk..PivvhssaGvGrtgtlililialeslr

ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
 .  . . ...|..|..|   .||. ||...|....|.   
lddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0044763 (Phosphotyrosine protein) phosphatases II 440-667 2.4e-35 117.2 In-house 1-169 (178) alignment 
Range on Protein: 440-667
Range on HMM: 1-169/178.0
PNPNSRVVLFLKFGIANSDYINANFIRGYrgqskAYIATQGPlpftiADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygvtetygdiqvtvr
| ...||.|.   |.  ||||||..| ..      |.....|     ||......|.  |.|.. |. .|..  ||..|||. .|               
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

kkvnhndytlttflvqhlerhvtrevIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsfTMPGPAVVHCSAGIGRTGVFIGADIGMREleetQMiDVLR
                          |.| ....||.|||| .. . .|.   .. ..  . .|| .||||||.||.|... |.. ..     .. ..  
..........................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.slee

IVANMRQDRGgMVQTKDQYVFLHKILYE
... .|. |  .|.. .|. .|...  .
aielvrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 443-665 1.6e-21 71.7 In-house 32-255 (290) alignment 
Range on Protein: 443-665
Range on HMM: 32-255/290.0
NSRVVLFLKFGIANSDYINANFIRGYRGQskAYIATQGPLPF-------TIADFWRMVWEQRTTVIIMTTGLVERNMA----KCNQYWPDTHGYGVteTY
..||||       |.||| ||..    |.  . |.|| |.         || .|| |. . . . ..|.    |..       |..| |.. |  .  ..
atrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel..kf

GDIQVTVRKKVNHNDYTLTTFLVQHlERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSResfTmpgPAVVHCSAGIGRTGVFIGADIGMRELE-
....|   .|....|    . .|.. . ..   | |... .| .. |.... .... .   . |.   |   |..|||  || |  ..   ..|.  .  
kgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkask...t...pvivHcvdGiSrsAalaaiilgyQkiae

ETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKIL
 .. . .  .. ..|. |  ..... .. |    .
tsgsvkledvlkalrkqralaitsalelafvdagi
0046846 (Phosphotyrosine protein) phosphatases II 455-670 9.8e-45 147.7 In-house 10-174 (176) alignment 
Range on Protein: 455-670
Range on HMM: 10-174/176.0
ANSDYINANFIRGYRgqskaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVtetygdiqvtvrkkvnhndytlttflv
 ..||||||.| |.|     .|||||||| |.|||..|..|.. |.... | .|| .. || .|||. ...|.                           
ldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

qhlerhvtreviHYWYTNWPDMGVPDNpSSVVDFLLETRRSRESFtmpGPAVVHCSAGIGRTGVFIGADigmreLEET-QMIDVLRIVANMRQDRG-GMV
            .|....|||.||||  . . ..| . |. ...    || .|||||||||||... |.     | |. . ..|. ..| .|. |  |.|
............qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgav

QTKDQYVFLHKILYEYAK
|| .|| ||.. .... |
qtpeQyrflyefellllk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 455-578 7.6e-11 36.4 In-house 11-126 (130) alignment 
Range on Protein: 455-578
Range on HMM: 11-126/130.0
ANSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMtTGLVERNmakcNQYWPDTHGYGVTETygDIQVTVRKKVNHNdYTLTTFLV
 . .||||.|. |  |... |. || ||  |  |||.|. |.   |...  | || .    ..||||.  .   |.  || ||. .. . . .  ...| 
qgntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvv.lgsveee....deywpdsePlewyee..diivtltdrdefk.nikasnle

QHL-ERHVTREVIHYWYTNWPDMGV
 .    .  . .  .  .|||  | 
iesdlneshqaltmfqisnwpsdgt
0051429 (Phosphotyrosine protein) phosphatases II 456-671 2.1e-53 177.0 In-house 3-227 (272) alignment 
Range on Protein: 456-671
Range on HMM: 3-227/272.0
NSDYINANFIRGYrGQ---SKAYIATQGPLPFTIADFWRMvWEQRTTVIIMTTGLVERNMAKCNQYWPDT--------HGYGVTETYGDIQVTVRKKVNH
 |.||||... || |.    .......|||| |.|||||. .|.. ..|.. ....||.. || .|||.           .  | .||.. ||. .....
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

NDYTLTTFLVQHL-ERHVTREVIHYWYTNWPDMGVPDNPssVVDFLLETRRsresftmPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMID-------
.||.|...|. .|   . .||| |..||.|||.|||...  ....| . ..       .|| .||||||..|||... ... .. .......|       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
 ....|. .|. | |.||| .||.||...| |....
yleeaveelraqrpgavqteeqylflyeallellrs
0043147 (Phosphotyrosine protein) phosphatases II 456-662 1.1e-43 144.2 In-house 4-154 (172) alignment 
Range on Protein: 456-662
Range on HMM: 4-154/172.0
NSDYINANFIRGYRGQSKaYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLvernmakcnqywpdthgygvtetygdiqvtvrkkvnhndytlttflvQ
.||||||... .|.   . .|||||||..|.||||||..|.  |.|.. |.|                                               .
gsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel...............................................l

HLERHVTREVIHYWYTNWPDMGVPdNPSSVVDFLLETRR--SRESftmPGPAVVHCSAGIGRTGVFIGADIGMreleetQMIDVLRIVANMRQDRGGMVQ
..  ...|..|.|.|..|||.||| ... . .||   ..   ...    || .||||||.||||... |.. .      . .... .|| .|. |.|.||
ydpellerlgiqylylpwpDhgvp.llellleflefidellalsp...ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TKDQYVFLH
...|| ||.
npsqyrfly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 456-674 1.6e-23 77.9 In-house 66-281 (312) alignment 
Range on Protein: 456-674
Range on HMM: 66-281/312.0
NSDYINANFIRGYrGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGV-------TETYGDIQVTVRKKVNHNDYT
.  || |||..    . . ...|||||  |.. ||...    .| ||. .|.||    || .|  |  |.         ||   .|..  . | .     
enfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrv

LtTFLVQHLERhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftmpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDR
|   .|.   .     . || .. ||| |.||   .   .|   .. .       | . |||||.|||| ..  .  .  |   .  .|  .   .|.||
l.kvvvkatgq..esklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdr

GGMVQTKDQYVFLHKILYEYAKRIGY
   |..  |||.  ... |.    | 
arsvrvfpqyvyalrcvleflyskgl
subfamily_eak_pd Subfamily eak 456-580 8e-14 45.8 In-house 77-196 (332) alignment 
Range on Protein: 456-580
Range on HMM: 77-196/332.0
NSDYINANFIrGYRGQSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGyGvTETYGDIQVTVRKKVNHNDYTLTTFLVQ
.  ||||  .  .    . || |  .    .  ||.|| ||..  |..    || .. | ..|.||         .| ..|. .. |..| .    . ..
rlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr.e.elkfGildverkefvkrniletrllels

HleRHVTREVIHYWYTNWPDMGVPD
      | .| || .  | .. .| 
k..GnethrvlhykvfGwtettlpk
0036282 (Phosphotyrosine protein) phosphatases II 457-663 3.2e-46 152.5 In-house 2-164 (174) alignment 
Range on Protein: 457-663
Range on HMM: 2-164/174.0
SDYINANFIRGYRGQSkAYIATQGPLPftiadFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDthgygvtetygdiqvtvrkkvnhndytlttflvqh
||||||... ...  .  .||.||||.     ||.|..|.. |...| . ..|... || .|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

LERHVTREVIHYWYTNWPDMGVPDNPSsVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMRELEeTQMIDVLRIVANMRQDRGGMVQTKD
|  . .|..|.|.|..|||.|||| .  . .|. . .. ...    || .||||||.||||....|.. .| |. . ..|.|..|. .|. |.||||| .
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYVFLHK
|| ||..
Qyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 457-667 6.2e-36 118.6 In-house 3-151 (151) alignment 
Range on Protein: 457-667
Range on HMM: 3-151/151.0
SDYINANFIRGYrgqskaYIATQGPLPftiaDFWRMVWEQRTTVIIMTTGLVERNmaKCNQYWPDTHgygvtetygdiqvtvrkkvnhndytlttflvqh
|||||.... |.      .....|||.    ||.....|.  ..|.. ....||.  .| .|.|..                                  
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

lerhvtREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRsresftM-PGPAVVHCSAGIGRTGVFIGADIGMREleetqmIDVLRIVANMRQDRGGMVQTK
      .||.|.....||| |.|... .|..|| . ..      . .|| .||||||.||||....... ..       ...  ... .|. |.|.||..
......ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpn

DQYVFLHKILYE
.|..|... |.|
qqflfqlfalle
0049260 (Phosphotyrosine protein) phosphatases II 471-663 8.5e-39 128.0 In-house 7-144 (152) alignment 
Range on Protein: 471-663
Range on HMM: 7-144/152.0
QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWpdthgygvtetygdiqvtvrkkvnhndytlttflvqhlerhvtreviHYWY
.....||||||.| |.||||||..|.  |.|.| | |.|..  ||.||.                                               .| .
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylh

TNWPDMGVPDNPSSVVDFLLETRRSreSFTMPGPAVVHCSAGIGRTGVFIGADIGMreleetQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
..|||.||||..  . ..||  ..        || .||||||.||||... |.. .      . .... .|| .|. | |.|....|. ||..
lpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 471-545 1.8e-09 31.4 In-house 234-302 (440) alignment 
Range on Protein: 471-545
Range on HMM: 234-302/440.0
QSKAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLverNMAKCNQYWPDTHgYGVteTYGDIQVTVRKKVNHN
. .|.|||| ||  |. ||||.| . | . |||   |   |   |  |||      |  |.| . |  .   | |
kknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt.rsv..tfgpftvghkgsenmn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 473-663 2.4e-33 110.0 In-house 5-198 (199) alignment 
Range on Protein: 473-663
Range on HMM: 5-198/199.0
KAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH--LERHVTREVIHYWY
. ||||| ||  |.||||.||||  .  |.|       . |    ||| |.    |  || . ||..  . . |||.|....         |||. || .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPDMGVPdNPSSVVDFLLETRRSRESFT--MPGPAVVHCSAGIGRTGVFIGADIGMRELEE--TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
| | .   | | .  | |.. .|     .      | .|||| | | ||||.  |||.|  ||  | ..|.. .   .|| | |.. . ..| |...
tswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 473-663 2.9e-33 109.7 In-house 4-197 (198) alignment 
Range on Protein: 473-663
Range on HMM: 4-197/198.0
KAYIATQGPLPFTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKKVNHNDYTLTTFLVQH--LERHVTREVIHYWY
. ||||| ||  |.||||.||||  .  |.|       . |    ||| |.    |  || . ||..  . . |||.|....         |||. || .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPDMGVPdNPSSVVDFLLETRRSRESFT--MPGPAVVHCSAGIGRTGVFIGADIGMRELEE--TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
| | .   | | .  | |.. .|     .      | .|||| | | ||||.  |||.|  ||  | ..|.. .   .|| | |.. . ..| |...
tswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 476-671 8.4e-20 65.4 In-house 93-287 (302) alignment 
Range on Protein: 476-671
Range on HMM: 93-287/302.0
IATQGPLPF---TIADFWRMVWEQRTTVIIMTTGLVERNMaKCNQYWPDTHGygVTETYGDIQVTVRKkVNHNDYTLTTFLVQHLERHVTREVIH--YWY
| .| |       ...|||||.... . . .  |  | .    ....| . |    ..||.. | .|| |.. . . | . .  |   ..  |.   |  
ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg..dykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvl

TNWPDMGVPDNPSSVVDFLLETrrSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAK
|||..  ||.. ....    .     ..     ..|.    |.|| |.|. . . . .|.. .   .  ||...|..|  .|.. .|||.|. .|  | |
tnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

R
.
k
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 484-660 1e-20 68.9 In-house 39-212 (255) alignment 
Range on Protein: 484-660
Range on HMM: 39-212/255.0
FTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKkvNHNDYTLTTF-LVQHLE-RHVTREVIHYWYTNWPDMGVPDN
.|.. |....  ..|.|..| . . | .. ||..|.|  .       . |..||. |  . .|  | |  .. .|  .  |..| || |. |..   |..
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekd..eklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

PSSVVDFLLETRRSResftmpgPAVVHCSAGIGRTGVFIGADIGMR----ELE--ETQMIDVLRIVANMRQDRGGMVQTKDQYVF
.  .   |   | |.       . |||||.||||.  |. |..  .     |.  ||  .| |... ..|. | . ..|  |  |
areilnilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 484-661 2.8e-19 63.7 In-house 102-280 (302) alignment 
Range on Protein: 484-661
Range on HMM: 102-280/302.0
FTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGYGVT-ETYG----DIQVTVRKKVNHNDYTLTTFLV--QHLERHVTREVIHYWYTNWPDM
 |.  .| .. . ......  ...|| .  || .|. |  |  ..   |     ...  . .  . ....| |  .  .. ...| . |    .. ||| 
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPDNPSSVVDFLletrRSRESFTMpgPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFL
| |... . .| |    .  ||.      .||||||.|||| ..    |.    . .. |.| ||  .|| | | ||...| ..|
Gapkeaytaldil....kfcesykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 484-660 7e-18 59.5 In-house 45-218 (263) alignment 
Range on Protein: 484-660
Range on HMM: 45-218/263.0
FTIADFWRMVWEQRTTVIIMTTGLVERNMAKCNQYWPDTHGygVTETYGDIQVTVRKkVNHNDYTLTTFLVQHLE-RHVTREVIHYWYTNWPDMGVPDNP
 ||. |....  ..|.|..| .   | .. ||..|.|  .       . ...|.. | | ..    |  |.. |. .  |..| || |. |..   | ..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekd..ekqklanvnvcttk.vqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

SSVVDFLLETRRSREsftmpgpAVVHCSAGIGRTGVFIGADIGMR----ELE--ETQMIDVLRIVANMRQDRGGMVQTKDQYVF
 ...  |  .| |..        |||||.||||.  |  |..  .     |.  .|  .| |... ..|. | . ..|  |  |
reilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 486-671 1.5e-07 24.3 In-house 131-311 (346) alignment 
Range on Protein: 486-671
Range on HMM: 131-311/346.0
IADFWRMVWEQR-TTVIIMTTGLVERNMAkCNQYWPDTHGYGVTetyGDIQVTVRKK-V--NHNDYTLTTfLVQHLERHVTREVIHywYTNWPDMGVPDN
. ||| |.....   | .|      .| .    .  .  ||  |   | . .  |.  |  . ..||.   | .     |  .| |  .. |  .  | .
vedfwymiyqeqihlvylmvpddklkntt.tslfndenggyqyt...gkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhh..hapwkhlqqppk

PSSVVDFLlETRRSRESFTMPGPAVVHcSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKR
   .. ..     | . .   |  ||    | ||.  ||||   ...|..    ... |. |..|.| | |..  ||  .. |...|  |
tlpiikmi.hqflsekqvqnagvcvvs.lfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiar
0048076 (Phosphotyrosine protein) phosphatases II 531-667 8.6e-26 85.7 In-house 13-141 (145) alignment 
Range on Protein: 531-667
Range on HMM: 13-141/145.0
YGDIQvTVRKKVNHNDYTLTT-FLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESftmPGPAVVHCSAGIGRTGVFIGADIGMRel
.|..  |...  .  |. .|| . . . .. ..|..|.|.|..|||.|||| .. . .||   .. ...   .|| .||||||.||||....|.. ..  
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll..

eetQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYE
   . ...  ... .|. | |.|.. .|. ||.. ..|
...lgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 538-667 2.5e-22 73.8 In-house 68-192 (440) alignment 
Range on Protein: 538-667
Range on HMM: 68-192/440.0
VRKKVNHNDYTLTTFLVqHLErhvTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQMIDV
  | | ..||  ....   .|   .| . .| |  ||| |||   . |. .. .   |.|  .  || .|||||| ||||| |  |  .|| . .. ||.
evkgvpdsdyinasyin.gie...srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsdqidi

LRIVANMRQDRGGMVQTKDQYVFLHKILYE
. .. .||..|  |||| .||.|.|. . |
fsfinsmrnnrpqmvqtpeqyafvheavle
0048179 (Phosphotyrosine protein) phosphatases II 542-663 1.6e-23 78.4 In-house 26-139 (144) alignment 
Range on Protein: 542-663
Range on HMM: 26-139/144.0
VNHNDYTLTTFLVQHLERHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSREsftMPGPAVVHCSAGIGRTGVFIGADIGMreleeT-QmIDVLRI
 ... .|. ..  ..   ...||.|.|....|||.|||| .. . .||   .. .|    .|| .||||||.||||... |.. .     . . ...  .
kklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleea

VANMRQDRGGMVQTKDQYVFLHK
.| .|. | |.|.. .|. ||..
lalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 546-668 2.4e-15 51.1 In-house 201-343 (350) alignment 
Range on Protein: 546-668
Range on HMM: 201-343/350.0
DYTLTTFLVQHLERHVtreVIHYWYTNWPDMGVPDNPSSVVDFLL------ETRRSRESF--TMPGPAVVHCSAGIGRTGVFIGADIGMRELEETQ----
 ..||   .   . .|   | .  . ||.|...  || |..  |       ..  ... .      | .||||||.||||...  |  . ..|  .    
nnsltaitlaasdPyv...vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk

----------MIDV-LRIVANMRQDRGGMVQTKDQYVFLHKILYEY
          . |.   || ..|. |  |||..||..|... |  |
esrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_CDKN3_pd Subfamily CDKN3 556-664 8.3e-06 19.5 In-house 90-191 (202) alignment 
Range on Protein: 556-664
Range on HMM: 90-191/202.0
HLERHVTREVIHYWYTNWPDMGVPDnPSSVVDFLLETRRSRESFTMpgpAVVHCSAGIGRTGVFIGADIGMreLEetQMIDVLRIVANMRQDRG-GMVQT
.|    ..  .   .   .| .||| ..| ...| | | . ....    ..|||  |.||. . |   . .  |.  ..|.    ....|. .| . .||
rlldlyqqaglivhhypiadglvpd.iasclkileelrinlkayrk...tlvhcygglgrsslviacllly..ld..dtiepkdaidklrdlkgsraiqt

KDQYVFLHKI
  || .|...
vkqynylsef
0038934 (Phosphotyrosine protein) phosphatases II 559-667 9.8e-10 33.9 In-house 73-175 (194) alignment 
Range on Protein: 559-667
Range on HMM: 73-175/194.0
RHVTREVIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESfTMPGPAVVHCSAGIGRTGVFIGADIGMReleetQMIDVLRIVANMRQDRGGMVQTKDQY
.....  |.|    .|| |.. . . . .||    .  .    .|  .||| ||.||||....| . .|     . ...   .| .|. |.|.... |..
eefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyl

VFLHKILYE
  |.|   |
eallkryke
subfamily_PTPDC1_pd Subfamily PTPDC1 559-663 1.8e-07 25.8 In-house 77-170 (182) alignment 
Range on Protein: 559-663
Range on HMM: 77-170/182.0
RHVTREVIHYWYtNWPDMGVPdnpssVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMreleeTQMIDVLRIVANMRQDRGGMVQTKDQY
  . .....| .  |.| ||.      .. .|.  .  ..    |   ||| || ||||| | . .       .. ..  . .  .|. |   .||..| 
almeqgiyvynf.gwkDygva.....sleriLdivkvvafalqegkvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqv

VFLHK
 ....
elvke
PTPc_DSPc_SM00012 565-666 4.4e-33 109.0 In-house 2-104 (105) alignment 
Range on Protein: 565-666
Range on HMM: 2-104/105.0
VIHYWYTNWPDMGVPDNPSSVVDFLLETRRSRESFTMPGPAVVHCSAGIGRTGVFIGADIGMRELEET-QMIDVLRIVANMRQDRGGMVQTKDQYVFLHK
| ||.||.|||.|||....|....| .......  .  .| |||||||.||||.|. .|| .. ||.. . .|...||  .|. | |||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ILY
.| 
all
subfamily_CDC14_pd Subfamily CDC14 602-659 2.7e-06 21.4 In-house 263-315 (328) alignment 
Range on Protein: 602-659
Range on HMM: 263-315/328.0
PGPAVVHCSAGIGRTGVFIGADIgMRELEetqmIDVLRIVANMRQDRGGMVQTKDQYV
 | ..||| ||.|||| .|.. . |.. .    .    ..| .|  | |.| .. |  
eGaiavhCkaGLGrtGtLiacyl.mkhyr....ftaaeaiawlricrPGsvigpqqkf
subfamily_CG42327_pd Subfamily CG42327 603-672 3.3e-23 76.8 In-house 248-318 (319) alignment 
Range on Protein: 603-672
Range on HMM: 248-318/319.0
GPAVVHCSAGIGRTGVFIGADIGMRELEET-QMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRI
|| ||||| |.||||. | .|| .|.|||. . .|. ..|  .|.||.  |.||.|| |..|.|.|||| .
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 606-669 6.1e-13 43.0 In-house 2-65 (69) alignment 
Range on Protein: 606-669
Range on HMM: 2-65/69.0
VVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|||||.| |||| ||   . |  .   ...|..  |  ||. |  ||  . .|.|.|  | |  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 606-669 1.2e-12 42.0 In-house 1-64 (69) alignment 
Range on Protein: 606-669
Range on HMM: 1-64/69.0
VVHCSAGIGRTGVFIGADIGMRELEETQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYA
|||||.| |||| ||   . |  .   ...|..  |  ||. |  ||  ...|.|.|  | |  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal