Gene AquePTP-Un-4 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP046_AA protein Get Run
AqueP046_AA_115-332 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 106-332 2.2e-60 200.3 In-house 2-242 (307) alignment 
Range on Protein: 106-332
Range on HMM: 2-242/307.0
EPEVKEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAP-----TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS---GSDYINANYI--------N
.......|.. .. ..| ... .  ... .|| .. . . .     .  . ..||..||. .| .|||.||.| . ..   .||||||.|.        .
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

GYDEkSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMI-GSNEKKT
|||  .  .||||.|| .| ..|| |.||.   ||||||.|||...|||.|||| .    . .| .  |  |||.|.. ..||.|.| ...  |..|  |
gydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde....geeltygnftvtllseehldgytvrtlevtdldgtgesrt

VDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA--PYDGPMVVHCR
| ..|.|.||.||.|.|  .||.|...|.. ..  | .||..|||.
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 106-331 9.1e-42 138.2 In-house 3-224 (297) alignment 
Range on Protein: 106-331
Range on HMM: 3-224/297.0
EPEVKEPIPVIDFAKHVETmhNNQDYLFTEEFFRIePDH--APTRRATKN-NKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEksgSYIA
 |  ..|||. |||  |..  | .  .|.|||  . |     |.  | |. | |..|.  |  || ||| |.   .   |||.|| ...|. .    .|.
spkerrpiplsdfatlvqk..nrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlit

TQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSAIEGenvlkFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNH
|| |  .| ..|| ||..... .||||... |.|| || .||.....       | .  ..||  |  | .  |.|...   .  .. |.||.|..||..
tqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdk

GTPS--SSGPLLEFMDIVQQKYAPYDG-PMVVHC
  .   |   ||.... |....      |..|||
averkdsassllklisevrkdfsqnaegPllvhc
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 108-331 7e-55 181.4 In-house 4-230 (298) alignment 
Range on Protein: 108-331
Range on HMM: 4-230/298.0
EVKEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHA-----PTRR-ATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDEKSgSYI
|.....  . . | .. .....   ...|| |..          ..   ...||..||. .| |.|.||||||.      |||||| ....|.... ..|
eieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afi

ATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenvlKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPN
|||||| .| ..|| ||.|... .|||||||.| || |.|.|||..  |     .. .....||.. .   ...||| ..   ......| | ||||||.
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.....tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpd

HGTPSSSGPLLEFMDIVQQkYAPYDG--PMVVHC
.|.|. .  .|.... |.. .    |  |..|.|
kgvpenatsvldllrkvra.sqqqagnkpvivqC
0050432 (Phosphotyrosine protein) phosphatases II 109-331 3.4e-68 225.6 In-house 22-239 (308) alignment 
Range on Protein: 109-331
Range on HMM: 22-239/308.0
VKEPIPVIDFAKHVETmhNNQDYLFTEEFFRIEPDHA---PTRRATKNNKERNRFLSIAAYDHSRVVLehhPSGSDYINANYINGYD-EKSGSYIATQAP
......|.|..|..|    .. .|. |||...         .  . ..||..||. .| .||||||.|   ..|||||||.|..||.  ..  .||||.|
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgP

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAieGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPS
| .| . || |||| . .||||||.||||..|||.|||| .   |...|..  | .|||.| |...||.|.| ....|..| .|| ..|.|.||.||.|.
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel..gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

SSGPLLEFMDIVQQKYapYDGPMVVHC
|  .||.|...|....   .||.||||
speilldflelvrksl..pggpivVHC
subfamily_PTPRD_pd Subfamily PTPRD 110-331 4.5e-81 268.2 In-house 2-221 (564) alignment 
Range on Protein: 110-331
Range on HMM: 2-221/564.0
KEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRAT--KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDeKSGSYIATQAPL
..|||| ....||. .. |.|. |.||. .||. .  | .|   . ||..||.  | |||||||||.. .  .|||||||..|.||. |. .|||||.||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

ASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiEgenVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSS
|.| ..|| ||||..  .|||||.|.|..|.|||.|||..  .     .. ... || ||   ..|.||....|.  |.|...| |.||||||.|| | |
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g...tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

SGPLLEFMDIVQQKYAPYDGPMVVHC
  .||.... |..   |  ||.||||
atslLdlirkvralnepdagPivVhC
subfamily_PTPRB_pd Subfamily PTPRB 110-331 2.5e-65 215.4 In-house 4-225 (293) alignment 
Range on Protein: 110-331
Range on HMM: 4-225/293.0
KEPIPVIDFAKHVETMHNNQDYLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVL--EHHPSGSDYINANYINGYDEKSgSYIATQAP
..|| . .|..||..|....|. |.||. ..   . |.| .   .. |...||.  | .|||||| |   .. |||||||||||.||  .   .|||| |
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGP

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPS
| .| ..|| |||||.. .|||||.|||. |.||..|||.     |.   . . ..||..|.. |...||.|.|.   ..|...| ||||||||.|| |.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPe

SSGPLLEFMDIVQQKY--APYDGPMVVHC
.. .||.|.  |...   .  ..|.||||
ktktlldfvrtvreaiektaskrPivvhC
subfamily_PTPRA_pd Subfamily PTPRA 110-331 4.7e-55 181.8 In-house 11-235 (330) alignment 
Range on Protein: 110-331
Range on HMM: 11-235/330.0
KEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPD--HAPTRRATK-NNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAP
  |.|| .. . ..    ..  || |||  .     .|    |.| .|||.||.. |  ||.|||.| .      |||||| .|.|| ||  ..||.| |
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd.kfiaaqGP

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIG----SNEKKTVDQYHFTSWPNH
.. | ..|| |.||...  |||||.| | ..|||.||||.     | .. .    ... .| | ..||.||. .. ..     .... | |.||||||. 
keetvedfwrmiweqksativmltelkerkeekcaqywPd.....eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv

GTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
| |. .  .|...  |...   . ||.||||
GvPfepiGmlkllkkvkklnqqsagpivvhc
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 110-194 1.7e-11 38.2 In-house 3-89 (440) alignment 
Range on Protein: 110-194
Range on HMM: 3-89/440.0
KEPIPVIDFAKHVETmhNNQDYLFTEEFFRIEP-DHAPTRRAT-KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEK
. || | ||| .|.   | .   | .|.  .      |. .|.  ||| .||. .| |||||||.||.      |||||| |||| . .
qrpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 111-331 2.2e-58 192.8 In-house 3-223 (319) alignment 
Range on Protein: 111-331
Range on HMM: 3-223/319.0
EPIPVIDFAKHVETMHNNQDYLFTEEFFRIE-PDHAPTRRAT-KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAPLA
..|.| ............ . |. .||  .. ..   .. |. ..||..||.  | |||..|||| . .   |||||||..|.||.|..  .|||||||.
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPle

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSN-EKKTVDQYHFTSWPNHGTPSS
 | ..|| ||||.|. ..||||.|||. | |...|||.     ||. ..  . .||.||   |.| ||||...   |. | ..| ....|.||.|. | .
ntiedfWrmvWeeessivvmltklveklkvklkkywpe.....enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek

SGPLLEFMDIVQQKY-APYDGPMVVHC
.  ||...  ...    . .||.||||
atslldllkrirksrektqsgPivvhC
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 111-331 2.1e-38 126.7 In-house 2-176 (392) alignment 
Range on Protein: 111-331
Range on HMM: 2-176/392.0
EPIPVIDFAKHVEtmHNNQDYLFTEEFFRI-EPDHAPTRRATK-NNKERNRFLSIAAYDHSRVVLE--HHPSGSDYINANYINGYDEKSgSYIATQAPLA
.|||| .|   ||  .| .  ||.|||. . .||  |.. | |  |...||.  |  || .||.||     . |||.|| ||...| .  .|||.|.| |
qpipvaqfpafve..knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek.ayiasqgpna

STANEFWCMVWEKEAPVIVMLTNLVENDkekchqywpksaiegenvlkfssfeltlleesvnehytirklsikmiGSNEKKTVDQYHFTSWPNHGTPSSS
.. ..|| ||.....  |.|.|.| | |                                                 ....|| |.||| ||... |  .
aslddfwrmvfqenvttiamvtklkegd...............................................kgddartvaqfhftewPdkdvpkht

GPLLEFMDIVQQKYAPYDGPMVVHC
  ||.|.  |. ..  |  |...||
ssllkfikevkadfGqythpliihc
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 111-202 1.3e-15 51.3 In-house 3-94 (95) alignment 
Range on Protein: 111-202
Range on HMM: 3-94/95.0
EPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPD--HAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHpSGSDYINANYINGYDEKSgSYIATQ
 || |  |  ||  || | |  | .||  |      . |  ... |  .|||| |  || .||||  .   |||||| ...||  |   |||.|
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk.rdsdyinacfvdgyarkn.cyiaaq
0051299 (Phosphotyrosine protein) phosphatases II 112-332 1.1e-68 227.2 In-house 4-227 (288) alignment 
Range on Protein: 112-332
Range on HMM: 4-227/288.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAP---TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSGsYIATQAPLA
.|.| ...|.|.... |. ... ||| .. .  ..   .  . ..|.|.||. .| .||||||.| . ..  |||||||.||.||. |   .||||.|| 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlp

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMI----GSNEKKTVDQYHFTSWPNHGT
.| ..|| ||||.. .||||||.|||...|||.||||      ...|..  .  |||.| |...||.|.| .. .    |..|..|| ..|.|.||.||.
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
|.|  .||.|. .|....|. .||.||||.
pdspellldflrlvrkalasgggpvvVHCs
0043336 (Phosphotyrosine protein) phosphatases II 112-331 5.2e-63 208.4 In-house 1-217 (278) alignment 
Range on Protein: 112-331
Range on HMM: 1-217/278.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRAT--KNNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEKSGsYIATQAPLAS
||.| |..|...... |  .|. .||...   . .|.. .  ..||..||. .| .||||||.|.. ..   ||||||.|..||. . . .||||.|| .
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpe

TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSG
| . || ||||   ..|||||.|||....||.||||      ...|..  |  |||.| ....||.|.| ... |..|..|| .||...|| ||.|.|  
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp......ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpesls

PLLEFMDIVQQKYAPYDGPMVVHC
.||.|. .|...... .||..|||
llldflkavrealedsngpvlVHC
0039614 (Phosphotyrosine protein) phosphatases II 112-331 8.9e-60 198.0 In-house 15-229 (297) alignment 
Range on Protein: 112-331
Range on HMM: 15-229/297.0
PIPVIDFAKHVetMHNNQDYLFTEEFFRIE---PDhaPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPS---GSDYINANYINGYDEKSGSYIATQAPL
|. |.|.....  .. |. .|. .||...    ||   .  . ..||..||. .| .||||||.| . ..   .||||||.|..|||  .  .||||.||
plsvldlllll..ekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

ASTANEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSAIegenvlKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPSS
 .| . || ||||   .||||||.|||... ||.|||| .        ..  |  |||.. ....||.|.|....  ..| .|| ....|.|| ||.|.|
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvpps

SGPLLEFMDIVQQKYA--PYDGPMVVHC
.  ||||...|.. .|  | .||..|||
lellleflelvrealaelpkggpvlVHC
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 112-331 4.1e-57 188.7 In-house 3-223 (305) alignment 
Range on Protein: 112-331
Range on HMM: 3-223/305.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTR-RATKNNKERNRFLSIAAYDHSRVVLEHHPSGS--DYINANYINGYDEKSgSYIATQAPLAST
.| . |.|.... .. ..|  . ...  .  .. ..    ...||..||. .|  .|..|. | ...|    |||||.|..||..|  .||..|.|| .|
iialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk.kyivaqgPlknt

ANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenVLKFSSFELTLLEESVNEHYTIRKLSIKM-IGSNEKKTVDQYHFTSWPNHGTPSSSG
 ..|| ...|    .|||||.|||..|.||.||||.|  |   . .| .|...| .|.  . |..|||.| .  ...|..|| ||..|.||.|| | ...
vadfWrliveekvstivmltklveggkdkCrqYWpeskte...kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PLLEFMDIVQQKYAPYDG-PMVVHC
 ||.... ||...    | |..|||
sllslikrvqkdqkkdkgvpllVhC
subfamily_Ptp69D_pd Subfamily Ptp69D 112-332 3.9e-54 178.9 In-house 3-227 (307) alignment 
Range on Protein: 112-332
Range on HMM: 3-227/307.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPT---RRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAPLA
.|...| .. ... ... |.....|. ..|  . .      . |.|. .||.  | |.|. ||.|.. .    ||||||..|.||.||  ..|| |.|. 
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPve

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegeNVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-----SNEKKTVDQYHFTSWPNHG
.|...|| |..|.|  .||||.|| | ...||..|||.      .  .. .   .| .|.  ..|.||.|.. ...      .... | |||.|.|..  
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDsk

TPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
 | ..  ||.... |.. |    .|.||||.
vPevargllklieqvrelyklnrsPivvhCs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 112-331 1.3e-51 170.3 In-house 2-217 (315) alignment 
Range on Protein: 112-331
Range on HMM: 2-217/315.0
PIPVIDFAKHVEtmHNNQDYLFTEEFFRI-EPDHAPTRRA-TKNNKERNRFLSIAAYDHSRVVL---EHHPsGSDYINANYINGYDEKSgSYIATQAPLA
|||| .|   |.  .| .  ||.|||. . .||  ..| | ...| ..||.  |  .|..||.|   . .|  |||||| ||...|.   .|||.|.|| 
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsP.dsdyinasyiksvdddk.ayiasqgPlk

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiEGeNVLKFSSFELTLLEESVNEHYTIRKLsiKMIGSNEKKTVDQYHFTSWPNHGTPSSS
.. ..|| ||.....  |||.|.. |.|| || ||||.   .. .  .| |....||. . .   ..|||   .  |.|..|| |..|| ||..|..  .
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr..ka.dsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqt

GPLLEFMDIVQQKYAPYDGPMVVHC
. ||...  |. .  ... ...|||
ssllklikevkadngkkefsllvhc
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 112-332 1.8e-50 166.7 In-house 5-220 (315) alignment 
Range on Protein: 112-332
Range on HMM: 5-220/315.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDH-APTRRATK-NNKERNRFLSIAAYDHSRVVL--EHHPSGSDYINANYINGYDEKSgSYIATQAPLAS
|||. ..  .|   . .    | ...  |   .  | . | | .||..||.  | |||.||| |      ..|||.|||.|.||. |   |||.|.|...
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr.ryiaaqgpnva

TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegenVLKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPSSSG
. ..|| .|.|..   |||||||||..|.|. .|||         . .  . .|. .| ||..||.| ||. .   .. ..| |.|.||||. | | .. 
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk......kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkyti

PLLEFMDIVQQKYAPYDGPMVVHCR
||....  |.|      |..||||.
plmnlirtvkqhhtnsvgaivvhcs
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 112-331 3.6e-47 155.6 In-house 1-216 (515) alignment 
Range on Protein: 112-331
Range on HMM: 1-216/515.0
PIPVIDFAKHVEtmHNNQDYLFTEEFFR-IEPDHAPTRRATK-NNKERNRFLSIAAYDHSRVVLE---HHPsGSDYINANYINGYDEKSgSYIATQAPLA
|.|. .|   |.  .|..  ||.|||     |.  |   | .  | ..||.  |  || .|| ||     |  |||.|| ||...|    .|||.|.|. 
plplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnP.hsdyfnasyipsfdndk.ayiasqgPnk

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAieGeNVLKFSSFELTLLEESVNEHYTIRKLsiKMIGSNEKKTVDQYHFTSWPNHGTPSSS
.. ..|| .|....   |.|.|.| |.|| || .|||.    | . .|| |... |.  .     ..|||  ... ... .|| |.||| ||..|.|  .
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp..g.dsvkfGsikvelvsleactggikrkl..tvlkgddsrtvtqfhfteWPdkGvpkht

GPLLEFMDIVQQKYAPYDGPMVVHC
  || ..  |. .   |  |...||
ssllklikevkadhgqythpliihc
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 113-331 1.6e-65 216.3 In-house 2-220 (318) alignment 
Range on Protein: 113-331
Range on HMM: 2-220/318.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAP--TR-RATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDeKSGSYIATQAPLAS
|.| |...||. .... . |..||. |......   .    .. || .||.  | ||||.|| |..     ||||||||||.||  .. .|||.||||. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegeNVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSG
| ..|| ||||... ||||||...|. |.|.|.|||..     .  .. .   .| ||   ..|..|.....  ...|...| |||.||||..|.|.|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.....gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesga

PLLEFMDIVQQKY-APYDGPMVVHC
 ||...  |..    .  ||.||||
slldlvrqvskaqqksgagpivvhC
subfamily_PTPRG_pd Subfamily PTPRG 113-332 7.3e-65 214.2 In-house 1-228 (563) alignment 
Range on Protein: 113-332
Range on HMM: 1-228/563.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPT----R-RATKNNKERNRFLSIAAYDHSRVVLEHHPS--GS-DYINANYINGYDeKSGSYIATQAP
.|| .|||||  .| ..|  |.|||  ..  ....         ..||..|| |.| |||.||| |.  |   .. ||||||||.||  ||  .|||| |
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGS------NEKKTVDQYHFTSWP
|..|.. || |.||... .|||.|||||. ..||..||||     ...... ....|| || |   ||.|.|.|| .        ...|.| |||.|.||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP

NHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
.||.|..| | | |.   ..      ||.||||.
dhgvPehslpvLifvkkssaankaeaGPivvHcs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 113-331 5.4e-57 187.9 In-house 2-223 (290) alignment 
Range on Protein: 113-331
Range on HMM: 2-223/290.0
IPVIDFAKHVETMHNNQDYLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSGSD----YINANYINGYDEKSgSYIATQAPL
||| .|...|.. | ...  | ..| ..   | .|. |.  |..||..|||  |  ||  |..| . ..  |    |||| ||.|| ||  .|||||.|.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekk.qyiatqgpv

ASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenVlkFSSFELTLLEESVNEHYTIRKLSIKMIGS-NEKKTVDQYHFTSWPNHG-TP
 .|. .|| ..|... ..|||||| .|..|.||.||||.|  .      .  |...||.|.. ..|..|||..|   | ..|..| ||..|.|...|  .
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtk...a..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvt

SSSGPLLEFMDIVQQKYAPYDGPMVVHC
  .. || .  ...... . ....||||
npqtillvieemyktqrkrgntsivvHC
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 113-331 1.7e-55 183.1 In-house 2-218 (287) alignment 
Range on Protein: 113-331
Range on HMM: 2-218/287.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEP----DHAPTRRATKNNKERNRFLSIAAYDHSRVVLEhhPSGSDYINANYINGYDEKSgSYIATQAPLAST
|||  |.. |.. |.. .  |.. |  .|     ..  |   ...||..||.  |  .|  ||.|.      ||||| .|.|| ||   .|....|...|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekk.afiiaesPmfnt

ANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegeNvLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHG-TPSSS
| .||....... ..||||... |||.|.|.||||...    . . .  ....||.| ||..|..||| .|  . ...|..| ||..|.|...|  ..  
arnfWkliddrnvtaivmlcqekendeevcyqyWpeek....s.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq

GPLLEFMDIVQQKYAPYDGPMVVHC
  || . . ..... . ....||||
tillvieemyktqrkrgntsivvhC
subfamily_PTPRK_pd Subfamily PTPRK 113-331 2.5e-52 172.6 In-house 4-217 (314) alignment 
Range on Protein: 113-331
Range on HMM: 4-217/314.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRatKNNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDeKSGSYIATQAPLASTAN
| | |  ... ... .. | | ||.  .      ...  ..|.|.||.  | |||.|||.|        ||||||..|..|  ..  .|.|| || .| .
irvadllqsiallkraegygfkeeyeslfegwdaakk..denreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvk

EFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenvlkFSSFELTLLEESVNEHYTIRKLSIKM--IGSNEKKTVDQYHFTSWPNHGTPSSSGP
.|| .|.....  |||||.|||. . || .|||. .        .  ....|.| .... . .| ....    | .|...| |..|..||.|..| |   
dfWrlvydencasivmltelvevgrvkClkyWPedtev......ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

LLEFMDIVQQKYAPYDGPMVVHC
||...  |... .. .|..||||
llklvrrvkksqeeeaGrivvhC
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 113-331 2.3e-42 140.3 In-house 5-228 (325) alignment 
Range on Protein: 113-331
Range on HMM: 5-228/325.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRA--TKNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKsGSYIATQAPLAST
| |... .|||  . ...  |. ||  . .| . ....    .||..|||  . |.|.||||||     . ||||||.|.. . .|   ..|.||||..|
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltat

ANEFWCMVWEKEAPVIVMlTNLVENDKEKCHQYWPKSAieGeNVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGT---PSS
 |..| .| . ...|.|. .| ....|..| .||||    | .  .| ..|. |        |  |.| .| .   | ..| |... ||.. |.   |..
indlWrlvldWrcsvvvv.lneldlgkdrcavywpkem..g.ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpat

SGPLLEFMDIVQQKYAP---YDGPMVVHC
  ..|. .. |...        .|..|||
lisilqlvkavservtantkastpilvhc
0040438 (Phosphotyrosine protein) phosphatases II 115-331 1.6e-64 213.6 In-house 2-216 (317) alignment 
Range on Protein: 115-331
Range on HMM: 2-216/317.0
VIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTR--RATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSGsYIATQAPLASTAN
| |. .......... ... |||...   . .|.   . ..||..||. .|  ||||||.| . ..  .||||||.|..|...|   .||||.|| .| .
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntve

EFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLL
 || ||||    ||||||.|.|...|||.||||      ...|..  |  |||.| .....|.|.| ..  |..|. || ..|.|.|| ||.|.|  .||
dFwrmvweqgvtvivmLteleelgrekcaqYwpl.....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdlll

EFMDIVQQKYAPYDGPMVVHC
.|...|...... .||..|||
dfleavrealedpggpvlVHC
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 117-331 4.2e-40 132.3 In-house 4-233 (301) alignment 
Range on Protein: 117-331
Range on HMM: 4-233/301.0
DFAKHVETMHNNQdylFTEEFFRIEPDHAP--TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS----GSDYINANYINGYDEKSgSYIATQAPLASTAN
|  .|| ..|.|.   | |.. ...  .    |   ...||. ||| .|. ||. |..|...|.      .||||.||.|| ||   .||.|.|. .|  
dlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk.kfiaaqgpmkktlv

EFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEGENvlkFSSFELTLLEESVNEHYTIRKLSIKMI-GSN--------------EKKTVDQYHFT
.||...|..    |||.||| |. |.||.||||.|  | |.   |  |. || .| |   ..||.|..|.  |||              . ..| |.. |
dfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee...fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvt

SWPNHGT-PSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.||..|  .     |    |.....  .  ||.||||
dWpqdGvvreprtvLqviddvihrqqkigggpvvVHC
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 117-331 3.4e-38 126.2 In-house 6-219 (439) alignment 
Range on Protein: 117-331
Range on HMM: 6-219/439.0
DFAKHVETMHNNQDYLFTEEFFRIE---PDHA--PTRRATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSgSYIATQAPLASTA
.| .||| ...|.. .|.|.|  |.   ||.|   .  | . .. .||. ...|.||.||.|.  |    | |||||||.|| ..   |||||.|   |.
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddk.lyiatqgpkkett

NEFWCMVWEKEAPVIVMLTNLVENDKekchqYWPKSAiegeNvLKFSSFELTLLEESVNEHYTIRKLSI--KMIGSNEKKTVDQYHFTSWPNHGTPSSSG
..|| .|.|| .  |||||||||  |     ||| .|    .   .    .    .    .|.|| . .  .   .. ..|| |.|...||..  |. . 
ddfwrlviekktvtivmltnlvesyk.....ywpsda....e.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas

PLLEFMDIVQQK-YAPYDGPMVVHC
 .|.|.  ..        ||.||||
hvldflrainsandkeeygpvvvhc
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 119-331 4.6e-57 188.3 In-house 3-215 (281) alignment 
Range on Protein: 119-331
Range on HMM: 3-215/281.0
AKHVETMHNNQDYLFTEEFFRIEP-DHAPTRRATK--NNKERNRFLSIAAYDHSRVVL--EHHPSGSDYINANYINGYDEKSgSYIATQAPLASTANEFW
 ||......|..  |.||.  ..  .   | .|.|  .|...||.  | |||..||..  ... . .||||||...||...   |||||.|. .. ..||
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek.eyiatqgPvPaslvafW

CMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegeNVLKFSSFELTLLEESVNEHYTIRKLSIkMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFM
 ||||... .|||.|. .|..| |||.|||  .    . ||.. . .. ..|. ...|  ||...    |.|...| | ..|.||.|| |...  |||| 
qmvweqkvsaivmvtreieagklkChrYWPddn....selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefr

DIVQQKYAPY-DGPMVVHC
. |..   .  . |.|.||
kevlkltekktkaplvihC
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 119-331 8.4e-55 180.8 In-house 9-219 (288) alignment 
Range on Protein: 119-331
Range on HMM: 9-219/288.0
AKHVETMHNNQDYLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDEKsGSYIATQAPLASTANEFW
 ..|  .. ..   |.||.  .   | ... |     .|...||.  | .||. || |..  . .|.|||||.||.|...|   |||||.|||.| |.||
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfW

CMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKmiGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFM
 .|.|...  |||||.|||..|.||..|||..    ..  .. |...||.|.   |... ||| ..   .... .. ||....||.|| | |. ||||..
elvyenktstivmltelveggktkCeeYWPda....dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllell

DIVQQKYAPYDGPMVVHC
..|..      ||..|||
rqvkvanqadtgpiivhC
subfamily_ptpA1_pd Subfamily ptpA1 120-317 2e-29 97.6 In-house 15-216 (418) alignment 
Range on Protein: 120-317
Range on HMM: 15-216/418.0
KHVETMHNnqdylFTEEFFRIEPDHAPTR---RATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDEKsgSYIATQAPLASTANEFWC
.|.. .|.       |||  .|    |.       | |  .||.  |   .|.|| |..     ||||||||||.|   |   .|.|| ||  |  .|| 
nhikcihk.....ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwr

MVWEKEAPVIVMLTNLVENDKEKCHQYWPKS------AIEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGP
||||. . .||||.   || . || .|||.       .| |.    | .. . |.|   .    |    |..    | . . ||..  ||.|  |  . |
mvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqp

LLEFMDIVQ
. ...  . 
frqllhsit
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 125-312 1.2e-35 117.8 In-house 9-189 (297) alignment 
Range on Protein: 125-312
Range on HMM: 9-189/297.0
MHNNQDYLFTEEffrIEPDHAPTRRATKnnKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDEKSG-SYIATQAPLASTANEFWCMVWEKEAPV
.....| |. |       . . ..| .     .||.  | |.| .|| |   ....|||||.|.   ||..   || .| || .| ..|| .|.|..  |
leaekdllldea...rgesfssakrnss..lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrv

IVMLTNLVENDKEKCHQYWPKSAIEGenvLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEF
|||...| |. ..||  |||..  |.   || ... .  | .  .|. ..    ...|  .|.. |    | |||.|| ||    |  |
ivmvaklqedGrdkcapywpsvvqer...lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 126-331 5.5e-39 128.8 In-house 4-206 (283) alignment 
Range on Protein: 126-331
Range on HMM: 4-206/283.0
HNNQDYLFTEEFFRIE-PDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSgsDYINANYIN--GYDEKSGSYIATQAPLASTANEFWCMVWEKEAP
..|.  || | . |.  ||   .  ....||. ||.  | ..|  || |. ..   ||||| .|     ....  ||..|.||  |  .|| ||..... 
rvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

VIVMLTNLVENDKEKCHQYWPKsaiEGenVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKK-TVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA
 |||||.| |. ..|| |||||   .|    ..  | .|| .|  .. ..|..| ... .| ...  .  | .  | . |  .    |. |  .. ..  
aivmltklqedlrikCsqyWPk...rG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqte

PYDGPMVVHC
  .||.||||
skkgPivvhC
subfamily_PTPN14_pd Subfamily PTPN14 130-318 6.3e-39 128.8 In-house 23-214 (300) alignment 
Range on Protein: 130-318
Range on HMM: 23-214/300.0
DYLFTeEFFRIEPDHAPT--R-RATKNNKERNRFLSIAAYDHSRVVLEH-HPSGSDYINANYING-YDEKSGSYIATQAPLASTANEFWCMVWEKEAPVI
  .|| |. || . .. .     . ..|.|.|||  .  |...|| |   . . ..||||  |.     |. |||..|.||  | ..|| ||||..  .|
gkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli

VMLTNLVENDKEKCHQYWPKSAIeGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQ
||||.  |. |||...|.||.    .. ..|  |..|    .  . .. ..| .| . |.|..||    .| ||.|| |.   . |.... || 
vmlteeeedgkeksfkyfPkles.kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs
0036941 (Phosphotyrosine protein) phosphatases II 131-332 8.4e-64 211.0 In-house 13-215 (297) alignment 
Range on Protein: 131-332
Range on HMM: 13-215/297.0
YLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLehHPSGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVML
.|. .|| ..    ..   .  . ..|.|.||. .| .|||.||.|  ...|||||||.|..||| |   .||||.|| .| ..|| ||||   .|||||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvml

TNLVENDKEKCHQYWPksaIEGENVLKFSSFELTLLEESV--NEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQ--KYAPY
|.|||...|||.||||    | ...|..  | .|||...|  ...||.|.| ....|..|..|| ..|.|.|| ||.|.|  .||.|.. |..  |..| 
telvelgrekcaqywp...leegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

DGPMVVHCR
.||..|||.
ggpvlVHCs
subfamily_PTPN6_pd Subfamily PTPN6 133-331 3.4e-57 188.8 In-house 28-234 (306) alignment 
Range on Protein: 133-331
Range on HMM: 28-234/306.0
FTEEFFRI---EPDHAPTRRA--TKNNKERNRFLSIAAYDHSRVVL-EHHPSGSDYINANYIN-GYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIV
|.||| ..   |  .  .|.    ..|||.||. .|  .||.||.| |.. .||||||||||.    ... ||||||  | .| ..|| |||.... |||
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrviv

MLTNLVENDKEKCHQYWPKSAIEGEnvlkFSSFELTLLEESVNEHYTIRKLSIK-MIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYD
|.|. ||  |||| .|||..  . |    . . ..| ..|. ...|..|.||.. .  ..|...| ||||.|||.||.|.. | .|.|.. |..|.    
mttkevErgkekCarYWPdeeekee....yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

----GPMVVHC
    ||.||||
eaeagpivvhC
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 133-331 2.4e-52 172.7 In-house 7-208 (274) alignment 
Range on Protein: 133-331
Range on HMM: 7-208/274.0
FTEEFFRIEPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSGS---DYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTN
...||. .  .. .       ....||. .|   ..|||.||.. | .   .||||||| ||||.|  |.||| ||..| ..|| |....|..||||||.
lekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LVENDKEKCHQYWPKSaIEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSneKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKY---APYDGP
| |....||..|.|.. .. |   ..  .|..  .   ...|..|||..|   .  ...|  | .|.||.| .| .  .||.... |...    .   .|
lkeaneqkCavyfPda.edyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklap

MVVHC
.||||
vvvhC
subfamily_PTPN3_pd Subfamily PTPN3 134-331 6.2e-53 174.5 In-house 21-215 (280) alignment 
Range on Protein: 134-331
Range on HMM: 21-215/280.0
TEEFFRIEPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSgsDYINANYINGYDEK---SGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNL
 |...| .|. | .     .| ..||.  |..||. || |.. ..  |||||||.|   .    .  ||||| |||.||..|| ||||... .|||||.|
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VENDKEKCHQYWPKsaieGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVH
||. . |||||||.     |. |....|.... .|. .. | .|.| .|   ..|.... |  ...||.|| |..|  .|||.. |... .  . |.|||
verGrvkChqyWPe....tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

C
|
C
0047943 (Phosphotyrosine protein) phosphatases II 135-332 6e-63 208.2 In-house 16-213 (273) alignment 
Range on Protein: 135-332
Range on HMM: 16-213/273.0
EEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLehHPSGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLV
||| ..    |..  .  . ..||..||. .| .||||||.|  ...|||||||.|..||. |   .||||.|| .| ..|| ||||. ..||||||.||
eefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelv

ENDKEKCHQYWPKSaiEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP--YDGPMVV
|...|||.|||| .  .||..|..  |  |||.| ....||.|.| ....|..|..|| ..|.|.||.||.|.|  .||||...|.....    .||.||
elgrekcaqYwple..ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV

HCR
||.
HCs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 138-331 5.5e-22 73.0 In-house 16-199 (267) alignment 
Range on Protein: 138-331
Range on HMM: 16-199/267.0
FRIEPDHAP-TRRATKNNKERNRFLSIAAYDHSRVVLEHhpSGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDke
 .| ....  .   ...|.||||.     ||..||.|    .  .|||| |..||  |   .|.|| ||  |  .|. .. ... ||||.||.  ...  
kkisdtsstisqsiaeknqernrlddnlpyddtrvilrt..keeeyinasyvegyktkn.afivtqdplkntitdfltvihdqkvpvivlltkvftdn..

kCHQYWPKSAIEGEnvlKFSSFELTLLEESVNEHYTIRKLSIKMIgSNEKKTVDQYHFTSWPNHG-TPSSSGPLLEFmdIVQQKYAPYDGPMVVHC
  ...||    . .   |.  . .    |  .. | |  | .|.   .  . |  |..  |           ||.    . ...    . |.||.|
.irlfwPPkmgqak...kyqdltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgi..laknqlengnrPlvvac
subfamily_eak_pd Subfamily eak 139-305 7e-17 55.8 In-house 37-197 (332) alignment 
Range on Protein: 139-305
Range on HMM: 37-197/332.0
RIEPDHAPTRRATKNNKERNrFLSIAAYDHSRVVLEHHPS-GSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEK
. ..  . .  |  .. .||  . |  ||.  | |         ||||  .  . |    || | ..  .    || || |. .| ||.| . ||.. ||
dyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

CHQYWPKsaiEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPSS
  .|.|.   .. ..|||  ....  |   .. .  |.| ...   || . |  |..  | .  .|  
sdkyfpd...ktreelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpky
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 139-302 2.5e-15 50.7 In-house 80-235 (244) alignment 
Range on Protein: 139-302
Range on HMM: 80-235/244.0
RIEPDHAPTRRAT-KNNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKek
 | || .  . |   ||  .||  .   .| .|| | .   |  |||| .. |   ..  || || ||| |. .|| |. |.   |.|.|  . |.|.  
iirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede..

chqYWPKSaiegeNVLKFSSFELTLLEESVNEHYTIR--KLSIKMIGSNEKKTVDQYHFTSWPNHGT
   ||| |     . |..   ..|.     .|   |.  .| |.    . ....  .  . ||  ||
...ywpds.....eplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_PTPN13_pd Subfamily PTPN13 140-331 5.4e-46 152.1 In-house 23-209 (273) alignment 
Range on Protein: 140-331
Range on HMM: 23-209/273.0
IEPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSgsdYINANYING-YDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKC
. |    .   .|.||..||.  .  ||..|| |. . .   ||||..|.   ...  .|||.| ||  |...|| ||||..| ||.|.|. .|..| ||
lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

HQYWPKSAieGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApYDGPMVVHC
|.|||.|.  ....   . .|..||.    . ...|.| .| . |.| . | . .|..||.||.|||. .||.|.  |..      ||.||||
hrywPesk..nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhc
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 140-331 2.8e-21 70.8 In-house 27-211 (288) alignment 
Range on Protein: 140-331
Range on HMM: 27-211/288.0
IEPDHAPTRRATK--NNKERNRFLSIAAYDHSRVVLEHHPsgSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEK
  |..|. . ...  .|  |.|.  .   | .|| |.  |    ||.|| .     |    | .|||| .| .|.| |. |..   ||||..|.|  |||
dspneasidiidsfianptrdryenlprcditrvklsddp..dfyiaanvvssakyk.rrlicaqaPlngtieelWkmllesdveyivmlcellekGkek

CHQYWPKSAIEGENVLKFssfeLTLLE---ESVNEHYTIRKLSIKMIGSNeKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVqqkyAPYDGPMVVHC
  .|.|    |   . ..     |      . ..   ..  | |.  | . |. | . |.  |...| | .  . | .....      .. |.|||.
saeyfPsklGekarigrl....ctvvkkkradidklvkvsllriskegee.kvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhs
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 141-331 7.2e-30 99.0 In-house 29-216 (307) alignment 
Range on Protein: 141-331
Range on HMM: 29-216/307.0
EPDHAPTrRATKNNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQ
.|.  ..  | . | ..||.  . . |..|.|.. .   |||| |||. |   |   .|..| || .|  .||.|. ...   ..|| ...|  | ||.|
tpegvtv.eafsantdknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceq

YWPKSAI----EGENVLKFSSFELTLLEESvNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
|||         ||.    |  .|   . .  ..  |   ..|.  ... .|.... .. ||..|.|      ..... |. .      |.||||
ywpleegqklvfgeapntisvanlgakkla.pdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhc
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 143-331 5.7e-18 59.5 In-house 41-230 (310) alignment 
Range on Protein: 143-331
Range on HMM: 41-230/310.0
DHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSG-SDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQY
| . |  | |..  .||.  .   | ||| |.   |   ||| |||..    .| ..| .| ||  |  .|| |.... |  |..| . .|. . ||  |
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPKSAIEGenvlKFSSFELTLLEESVNEhYTIRKLSIKMIGSNE----------KKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
||   .       .    .| | || .| . | .|.. ..  |           .  |.  ..  ||. | |      .    . | .     || ||||
wpslgvte....tygcirvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr....hgpcvvhc
subfamily_egg_pd Subfamily egg 144-291 1.1e-23 78.4 In-house 29-176 (307) alignment 
Range on Protein: 144-291
Range on HMM: 29-176/307.0
HAP-TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENdkEKCHQ
. . |. |..||.|. |   .   | ||| || .      |.| ||...|       .| .||||  | ..|| ||...| . |||||  .|.  |.|. 
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPKSAIEGENVlKFSSFELTLLE--ESVNEHYTIRKLSIkmIGSNEKK-TVDQ
||||.  .   .    |.... |.  .  .  ... || .  .|.....  .. 
ywpkaesdslvt.vpGslrienlkvdskadplfrvtklkl..vGgddeerfleh
DSPc_SM00195 145-331 1.2e-58 193.9 In-house 17-202 (263) alignment 
Range on Protein: 145-331
Range on HMM: 17-202/263.0
APTRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYW
  |  . |.||..||.  |  |||.|| |.. .  .||||||||||.|. .|. .|||||.|| || ..|| ||||.. ..|||||. .||.||||..||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PKSAiegENVLKFSSFELTLLEESVNE-HYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
|...   ..  .| .....| |.   . ....|.|.... | .|...| ||....||.||.|.|  ..||..  |....   .||.||||
pees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC
PTPc_SM00194 145-331 1.2e-58 193.9 In-house 17-202 (263) alignment 
Range on Protein: 145-331
Range on HMM: 17-202/263.0
APTRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYW
  |  . |.||..||.  |  |||.|| |.. .  .||||||||||.|. .|. .|||||.|| || ..|| ||||.. ..|||||. .||.||||..||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PKSAiegENVLKFSSFELTLLEESVNE-HYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
|...   ..  .| .....| |.   . ....|.|.... | .|...| ||....||.||.|.|  ..||..  |....   .||.||||
pees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC
subfamily_PTPRN_pd Subfamily PTPRN 145-331 1.3e-46 153.7 In-house 48-231 (297) alignment 
Range on Protein: 145-331
Range on HMM: 48-231/297.0
APTRRAtKNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYW
. . .| ..| ..||  .. .|||||| |...   . ||||||  |   | .. .|||||.|||||  .|| ||||. . |||.||.| |.. ..|..||
kevaka.eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PKsaiEGENVlkFSSFELTLLEESV-NEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
|.   ||..|  .  .|. |. | .  . | .| . .| . ..| .|| |.|| |||..|.|.|. .||||   |.. |     |.||||
pd...eGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc
0046845 (Phosphotyrosine protein) phosphatases II 146-332 2.8e-64 212.6 In-house 20-212 (284) alignment 
Range on Protein: 146-332
Range on HMM: 20-212/284.0
PTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSG---SDYINANYINGYD----EKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKC
 .  . ..|...||. .| .||||||.| . ...   ||||||.|..|||     ..  .||||.|| .| ..|| ||||....||||||.||||..|||
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

HQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA--PYDGPMVVHCR
.|||| .    ..||..  |  |||.| |...||.|.|.....| ..| .|| ..|.||||.||.|.|. .||||...|.. .   |..||.||||.
aqYwple....gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs
0045098 (Phosphotyrosine protein) phosphatases II 146-332 6e-56 185.2 In-house 25-214 (278) alignment 
Range on Protein: 146-332
Range on HMM: 25-214/278.0
PTRRATKNNKERNRFLSIAAYDHSRVVlehhpsgsDYINANYINGYdekSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKs
 |     .|...||. .| .||||||.        |||||.||.||   .  .||||.|| ||.. || |.||   .||||||.|||...|||.||||  
itpalylgnldknRykdilpydhsrVk........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

aiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMI----GSNEKKTVDQYHFTSWPNHGTPSSS--GPLLEFMDIVQQKYA-------------PYDGP
    ...| .  |..|||.|.|...||.|.| .  .     ..|. .| ..|...|| ||.||..   ..||... ... ..             . .||
....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

MVVHCR
..|||.
vlVHCs
subfamily_PTPN12_pd Subfamily PTPN12 146-331 1e-53 177.1 In-house 32-214 (290) alignment 
Range on Protein: 146-331
Range on HMM: 32-214/290.0
PTRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWP
 .   ...|...||.  |  ||.|||.|...    ||||||||.|.| ..|  .|||.|.||. | ..|| |.|||.  ..||. ..||..| ||..|||
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

KsaiEGENVLKFSSFELTLLEE-SVNEHYTIRKLSIKMIgsNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.   |||. |.|..||.|| ||  |.. ..|| | ...   .|...| |.|.|.||.||.|||  .|||... |..     | |.||||
e...egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC
subfamily_PTPN1_pd Subfamily PTPN1 146-331 8.8e-50 164.0 In-house 23-208 (290) alignment 
Range on Protein: 146-331
Range on HMM: 23-208/290.0
PTRRA-TKNNKERNRFLSIAAYDHSRVVLEHHPSgsDYINANYINgYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPK
||| | ...|...||.  .  |||||..||..    |||||. ..  .|   ||| || ||..|.. || ||||...  .||| ..||... ||.||||.
ptreaklpenrnlnryrdvspydhsrikleradn..dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

SAIEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQK--YAPYDGPMVVHC
   | | .|. ......|..| ....||.|.| .. . ..| ... ..|.|.||. | |.| . .|.|.  |..    ..  || |.||
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc
subfamily_PTPN9_pd Subfamily PTPN9 147-321 1.8e-51 169.9 In-house 35-207 (297) alignment 
Range on Protein: 147-321
Range on HMM: 35-207/297.0
TRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPK
..  .. | |.||.  .  ||..||||.. .  . |||||||...|| .|  ..|||| ||  | ..|| ||||.|. |||| | .||. . || ||||.
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkk.afiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

saiEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA
   | |.. .|...... .|  ..|.|..|.| || .  .|...|  . |.|||..|.|||.  ||.... |..| |
...eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 147-331 4.1e-32 106.0 In-house 47-223 (290) alignment 
Range on Protein: 147-331
Range on HMM: 47-223/290.0
TRRATKNNK--ERNRFLSIAAYDHSRVVLEHHPSGsDYINANYINGYDeksGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPK
 |.   .|   ..||.  ..  | .||.|.    | ||. |||..| .     .| || .|..|. ..| || .... .|||| .|.|. | ||.||.|.
erkifdkntefkknrykdvvcndktrvilkdGydG.dyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

SAieGEnVLKFSSFELTLLEESVN-EHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
 .  || || | .. ..  ||. . ..   . ||..   |  .. .  ..  |||..  . |.  ||  . |...      ||.||||
ke..Ge.vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 147-331 2e-23 77.7 In-house 28-210 (285) alignment 
Range on Protein: 147-331
Range on HMM: 28-210/285.0
TRRATKNNKERNRFLSIAAYDHSRVVLEHHpsGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSA
|  | . | . ||.  . . . .||||. |    ||| |...    .   .||.|| ||  | ..|| |.....   ..||  |.|   |||  |.|.  
tytayeanpdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

ieGEnVLKFSSFELTLLEESVNEHYTIRKLSIKMIG----SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQqKYAPYDGPMVVHC
  || |.||  .|.|| |   .        .. .|     |.|   ... .   ||.. .|  . |..|.   |. |  | . |..|||
..ge.vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhc
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 149-309 8.2e-15 49.2 In-house 42-193 (303) alignment 
Range on Protein: 149-309
Range on HMM: 42-193/303.0
RATKNNKERNRFLSIAAYDHSRVVLehhpSGSDYINANYINGYDEKsgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaie
.   .| ..|||  .   |||.| |    | | || |.|..   .|    | || ||. || .|| |. |.   ....|    | ||   .  .|.    
nqfvknmdknrfvdvicldhskvkl....sdssyihasyleldssk..kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn...

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPL
 .. |||    . . |    |     .| .  .   . |  .  .|. .||    || . | 
.qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspk
subfamily_PTPN23_pd Subfamily PTPN23 150-331 1.5e-50 166.7 In-house 39-219 (288) alignment 
Range on Protein: 150-331
Range on HMM: 39-219/288.0
ATKNNKERNRFLSIAAYDHSRVVLEhhPSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAieg
. | . |.||.  |  |||.||.|.   |  ||||| ....    . ..|||||||.||.|.|| ||.|. ..|||||..  | .|.|...|||..    
iaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk...

ENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA----PYDGPMVVHC
..  ||  ...|| ..   |..  |.|.... .....|.|   ..||||..| |.| . ||.|.| |...|     . . |.||||
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC
subfamily_CG7180_pd Subfamily CG7180 150-331 3.7e-34 112.7 In-house 38-230 (296) alignment 
Range on Protein: 150-331
Range on HMM: 38-230/296.0
ATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSAi
  |.|.|.||   .  ||. |||||.    . |||||| |....  |   || |.||  .| .||| .|...|.  .|.||.  .  | ....|||. . 
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

egenVLKFSSFELTLLEESVNEHYTIRKLSIKMI----------GSNEKKTVDQYHFTSWPN-HGTPSSSGPLLEFMDIVQQ---KY--APYDGPMVVHC
      ..  ... ..||    . .||.. ..             . |...| ....| |.  .  |.|.  |.|..  |..   |    |  ||.||..
....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs
0049772 (Phosphotyrosine protein) phosphatases II 150-332 3e-25 85.0 In-house 42-220 (314) alignment 
Range on Protein: 150-332
Range on HMM: 42-220/314.0
ATKNNKERNRFLSIAAYDhSRVVLEHHP-SGSDYINANYINGYdeksGSYIATQAPLASTANEF----------WCMV--WEKEAPVIVM----------
    |...||.| |  .| .||.|   | ||||||||.|..|.     ..||||.||  | . |          | ||  ..    .|||          
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LTNLVENDkekchQ-----YWPKSAiegenvlkfssfeltlleesvnehytirklSIKMIGSNEKKTVDQYHFTSWPNHGTPsSSGPLL
           |..| .|            ...                                 ..   ..  .... .|. . .| ...| ..  ..
srLdaAlgKtpllildgng.....neptaadlellk..............................eelydpelferlgikylripvpDgsap.lledfd

EFMDIVQQKyaPYDGPMVVHCR
||......   . .|| .|||.
eflefieea..dkggpvlvHCk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 150-246 2.9e-08 27.5 In-house 47-142 (302) alignment 
Range on Protein: 150-246
Range on HMM: 47-142/302.0
ATKNNKERNRFLSIAAYDHSRVVLEHHPsgSDYINANYINGYDEKsGSYIATQAPLASTA---NEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSA
| |.| ..|.   . ..|. .| ||..|   .|.||  ..  . .  | | .| |  ...   .||| ||....   .|.|    | .|   ....|| .
afkknlkknqsedvpildsnlvkleaep..dsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks
0042113 (Phosphotyrosine protein) phosphatases II 151-332 5.7e-56 185.0 In-house 6-184 (245) alignment 
Range on Protein: 151-332
Range on HMM: 6-184/245.0
TKNNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaie
 ..||..||. .| .|||.||.| ....   ||||||.|..||. . . .||||.||..| . || |.||    .|||||...|....||.||||     
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA-PYDGPMVVHCR
 ...|..  |  |||.| ....||.|.|.....|..|...| .||...|| ||.|...  ||.|...|.. .| . .||..|||.
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs
0040439 (Phosphotyrosine protein) phosphatases II 151-331 1.1e-54 181.0 In-house 8-186 (249) alignment 
Range on Protein: 151-331
Range on HMM: 8-186/249.0
TKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaie
 ..||..||. .| .||||||.|.. |.  .||||||.||.||. |   .||||.|| .| . || |.||    ||||||.|||...|||.||||     
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA--PYDGPMVVHC
 ...|..  |  |||.. |...||.|.| ..... .|. || ....|.|| ||.|.|  .||.|...|.. ..  | .||..|||
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHC
0037934 (Phosphotyrosine protein) phosphatases II 151-332 3.8e-54 179.1 In-house 7-186 (243) alignment 
Range on Protein: 151-332
Range on HMM: 7-186/243.0
TKNNKERNRFLSIAAYDHSRVVLehhpSGSDYINANYINGYDeksgSYIATQAPLASTANE----FWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksa
 ..|...||. .| .||||||.|    .||||||||.|....     .||||.|| .| ..    || |.||    ||||||.|||...|||.||||   
lpenlsknrysdilpydhsrvkl....egsdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

iegENVlKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQK--------YAPYDGPMVVHCR
   ..|  .  |. |||.|.. ..||.|.|...... ......| .||...|| ||.|.|  .||.|.|.|..         ... .||..|||.
...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 151-331 2.3e-44 147.0 In-house 58-231 (319) alignment 
Range on Protein: 151-331
Range on HMM: 58-231/319.0
TKNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTnlvendKEKCHQYWPKSAIE
 ..||..||.  | |.|...| ||.     .|||||| ...||  |   |||.| ||  | ..|| |.|| ..  ||.||      |.|| ||||. . .
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

GENVLKfssFELTLLEESVNehYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP--YDGPMVVHC
 |.  |    .....||. .  |..|.. .   |  .... . |.||  ||..| | .. .|. ... |.          ..||||
keerfk...vkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 151-331 4.4e-24 79.7 In-house 52-228 (305) alignment 
Range on Protein: 151-331
Range on HMM: 52-228/305.0
TKNNKERNRFLSIAAYDHSRVVLEhHPSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEGE
.. .. .||.  . . |.| | |. .|| |||| |||.         .|..| ||  | .||| || ..    |||| . ||  | || |||| .  |  
adiaitknryqdvpcqdqsavkld.kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

NVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApydgPMVVHC
..      |       ..    |.   ...    ..| .| . ..| ||. | |      ||..  ..        |.||||
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhc
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 152-331 4.4e-51 168.5 In-house 7-182 (250) alignment 
Range on Protein: 152-331
Range on HMM: 7-182/250.0
KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEkCHQYWPKsaieg
 .|||.||.  | |.|.||||||..     |||||| ...||||.  ..||||.|| .| ..|| ||.|... .|||||||.|..|. .|||||      
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.....

ENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP-YDGPMVVHC
|.  |. .  ..||.. .   ||.||| .     .....| |.||..||. | |      ||... ||..     ..|..|.|
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 152-331 2.2e-44 146.4 In-house 6-181 (239) alignment 
Range on Protein: 152-331
Range on HMM: 6-181/239.0
KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIeg
. || .||.  | .|||||||||.      ||||||.|.  ||    .|||||  .. .. .|| |.|..   |||||| |.|  |.||||||| |.   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

envlKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
    |.  . .|| .  |   | || . .  .|  |.. | ||||| ||..| |  .  .| .   . .   |   | |.||
....kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 152-331 2.4e-44 146.3 In-house 5-180 (239) alignment 
Range on Protein: 152-331
Range on HMM: 5-180/239.0
KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIeg
. || .||.  | .|||||||||.      ||||||.|.  ||    .|||||  .. .. .|| |.|..   |||||| |.|  |.||||||| |.   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

envlKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
    |.  . .|| .  |   | || . .  .|  |.. | ||||| ||..| |  .  .| .   . .   |   | |.||
....kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 152-331 6.9e-44 145.4 In-house 23-195 (284) alignment 
Range on Protein: 152-331
Range on HMM: 23-195/284.0
KNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTnlvendKEKCHQYWPKSAIEG
..||..||.  | |.|...| ||.     .|||||| .|.||  |   ||||| ||  | ..|| |.|| ..  ||.||      |.|| ||||. . . 
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

ENVLKfssFELTLLEESVNehYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP--YDGPMVVHC
|.  |    .....||| .  |..|.. .   |  ...... |.||  ||..| | .. .|. ... |.          ..||||
eerfk...vkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 152-331 2.9e-42 139.5 In-house 18-204 (270) alignment 
Range on Protein: 152-331
Range on HMM: 18-204/270.0
KNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsAIEG
 ..|. ||.  |    ..||.||.    | . ||||||..|.|... .|||...||..| ..|| |.||.... |||.|.|.|. ..|| .|||.   . 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa.epke

ENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNeKKTVdQYHFTSWPNHGTPSSSG------PLLEFMDIVQQKYAPY--DGPMVVHC
.  |..   . . |.|. .| | ...| ..  |.. .. |  .....||.|| |....       ||. .  |..        .|..|||
kvkledgkikvlalseekeegyiltrlrleekgee.rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 152-331 7.6e-27 88.7 In-house 35-207 (281) alignment 
Range on Protein: 152-331
Range on HMM: 35-207/281.0
KNNKERNRFLSIAAYDHSRVVLEH---HPSGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAie
  |...||.| | . | ||| |.        .||| ||||     | | || || |   |  .|| |.|....  |||| ...| ..||| .|.|. |  
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg.yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGsnEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
   .|.|  . ..  . .||.     .| .   |  | . . .. .  ||.   | ||  .|. .  .. .      | |.||
.hcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkirar....stppvihc
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 152-241 1.9e-13 44.6 In-house 32-121 (332) alignment 
Range on Protein: 152-241
Range on HMM: 32-121/332.0
KNNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDEKSgSYIATQAPLAS-TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQY
 || . ||   . ..||||| |  .    |. ||....|| .|| .|| .|||.   |   || || |..  .|... .. |..| |.   
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskks.ayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 153-331 7.9e-48 157.7 In-house 2-179 (237) alignment 
Range on Protein: 153-331
Range on HMM: 2-179/237.0
NNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENV
.|| .||. .| |||||||||.   ||||||||.|..|.|    .|||.| || |. ..|| |||..   |||||| |.|....|||.|||..    .. 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst....dqp

LKFSSFELTLLEESVNEHYTIRKLSIKMI-GSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMD-IVQ-QKYAPYDGPMVVHC
  .  . ..|  .     ||.| | . .    .| . . ||.|||||..| |  .  || |   |..  .. .  || ..||
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 153-331 8.5e-40 131.3 In-house 37-217 (287) alignment 
Range on Protein: 153-331
Range on HMM: 37-217/287.0
NNKERNRFLSIAAYDHSRVVLEHHP-SGSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegEN
 . ..||.  .  .|..||.| ...  |||||||||. .| ..  ..||.|.|.|.| ..||..|.|... .....|  ||. . ||..|||.     | 
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer....ev

VLKFSSFELTLLEESVNE-HYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIV-----QQKYAPYDGPMVVHC
 ..   . ..||. .. | .|..| | .  . ..| . | |... |||... . ..  |. |.  |      .. |   ||.|||.
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd
subfamily_CG42327_pd Subfamily CG42327 153-314 3.4e-35 116.2 In-house 27-188 (319) alignment 
Range on Protein: 153-314
Range on HMM: 27-188/319.0
NNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiEGE
  |...|.. .    ..||||.. ..   . |..|.|. |||.   ||||.|..| ... .|| .|||. . ||| ||.| |.  ..| .|.| ..  ..
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke.tld

NVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFtSWPNHGTPSSSGPLLEFMD
|   .  . .|| .  |...| |  | .| .  .| . .  | .  |.. . |..  .|.  . 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 153-331 7.7e-27 88.8 In-house 47-226 (305) alignment 
Range on Protein: 153-331
Range on HMM: 47-226/305.0
NNKERNRFLSIAAYDHSRVVLeHHPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSA---IE-
.....||.  .   |. || | . |   .|| |||.     ..  .| |||||  |  .|| | ...    | || ||.|   .||..|..      .| 
qeagknrykdvgcldnnrvkl.egpwpheyihanyvstpt.npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

---GEN-VLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKtVDQYHFTSWPNHGTPSSSGPLLEFMdivqQKYAPYDGPMVVHC
   |.  ..|| | .   .... . . |  .| |.  |.. .| | .||.  ||. | |..   .||..    .|  |  ||.||||
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekark.vthyhwidwpdrgvpaadlailell....ekarpskgpivvhc
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 153-331 1.7e-16 54.8 In-house 42-216 (312) alignment 
Range on Protein: 153-331
Range on HMM: 42-216/312.0
NNKERNRFLSIAAYDHSRVVLEHHpsGSDYINANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKS----AIE
. |. ||.  |  .|  |  |        || ||...    |   ...||.|| .|.  || ..    .  |..|. .||.  ||| .|         .|
kfkdlnrypniqcwdrgrftlagd..enfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

GENVLKFSSFELTLLEESVnEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApydgPMVVHC
   |   .  |. .   |  .. | | | . .  . ..  ...| ..|||.|| | |    | ..  |..       |.. ||
dhrvyteycteieiggksk.dkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahc
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 153-226 1.7e-07 25.1 In-house 36-115 (347) alignment 
Range on Protein: 153-226
Range on HMM: 36-115/347.0
NNKERNRFLSIAAYDHSRVVLEHHP-------SGSDYINANYINgYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVM
.. ..||       | .||||               |||| .|. .|. |  || || || .|  .|| ||       .| 
kslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 153-244 2.6e-06 20.5 In-house 26-86 (169) alignment 
Range on Protein: 153-244
Range on HMM: 26-86/169.0
NNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINAnyingydeksgsyiatqaplastanefwCMVWEKEAPVIVMLTNlvENDKEkchQYWPK
 |. .||  .  |  | || |..  .  |||||||                             |.|| .| |||.| .   .||.   ..||.
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgd..tddkn...nfwpe
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 153-244 3.4e-06 20.0 In-house 25-85 (169) alignment 
Range on Protein: 153-244
Range on HMM: 25-85/169.0
NNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINAnyingydeksgsyiatqaplastanefwCMVWEKEAPVIVMLTNlvENDKEkchQYWPK
 |. .||  .  |  | || |..     |||||||                             |.|| .| |||.| .   .||.   ..||.
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGd..tddkn...nfwpe
Y_phosphatase Protein-tyrosine phosphatase 154-331 3.3e-58 192.3 Pfam-A 1-177 (235) alignment 
Range on Protein: 154-331
Range on HMM: 1-177/235.0
NKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVL
||..||. .| .||..|| |..... ||||||||..||. .. ..||||.|| || ..|| |||...  ||||||.|.|...|||.||||..    |. |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee...eesl

KFSSFELTLL-EES-VNEHYTIRKLSIKMIGSN-EKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.. .....|  .|.  ...||.|||..|  ... ||..| |.|.|.||.||.|.|. .||.... |... .. .||.||||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC
Y_phosphatase Protein-tyrosine phosphatase 154-331 3.3e-58 192.3 In-house 1-177 (235) alignment 
Range on Protein: 154-331
Range on HMM: 1-177/235.0
NKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVL
||..||. .| .||..|| |..... ||||||||..||. .. ..||||.|| || ..|| |||...  ||||||.|.|...|||.||||..    |. |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee...eesl

KFSSFELTLL-EES-VNEHYTIRKLSIKMIGSN-EKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.. .....|  .|.  ...||.|||..|  ... ||..| |.|.|.||.||.|.|. .||.... |... .. .||.||||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC
0041856 (Phosphotyrosine protein) phosphatases II 154-332 1.7e-29 98.1 In-house 1-117 (182) alignment 
Range on Protein: 154-332
Range on HMM: 1-117/182.0
NKERNRFLSIAAYDHSRvvlehhpsGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTnlvendkekCHQYWPksaiegenvl
|...||.  |  |||||        ..||||||.. |.   .  .||||.|| || ..|. |..|    .||.||         ...|||          
nldknrysdilpydhsr........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

kfssfeltlleesvnehytirklsikmigSNEKKTVDQYHFTSWPNHGTPSsSGPLLEFMDIVQQkyapYDGPMVVHCR
                             ....... ||....|| ||.|.    ||.|...|..     .|| .|||.
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 156-254 6.4e-28 92.5 In-house 49-162 (350) alignment 
Range on Protein: 156-254
Range on HMM: 49-162/350.0
ERNRFLSIAAYDHSRVVLE----------HHPSGSDYINANYINGY----DEKSGS-YIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQ
 .||.  |  |.|||| |.          |  |..|||||||..      . ...  |||||||| || ..|. .. . . .||..||..||.. |||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPKSAIEGENVLK
||.. .... .|  
YWqegsydditvkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 156-252 4.4e-15 49.8 In-house 50-163 (349) alignment 
Range on Protein: 156-252
Range on HMM: 50-163/349.0
ERNRFLSIAAYDHSRVVLEHHPSG----------------SDYINANYINGYD-EKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKC
 .||.  |  |.||||.|.. .                   |||||||..    .    |||||||| || ..|. ..  .. .... |..  |.. |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPKSAIEGENV
..|| . . .. .|
diywqelsysnitv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 159-331 5e-16 53.7 In-house 23-198 (290) alignment 
Range on Protein: 159-331
Range on HMM: 23-198/290.0
RFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKsgSYIATQAPLA-------STANEFWCMVWEKEAPVIVMLTNLVENDKE----KCHQYWPKS
. |...   ..||||. . .   .||| ||..   .      |.||.|..       || ..|| |. . ..  .||| .  |....     | .| |.|
qRlevpLveatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

AiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMiGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApydgPMVVHC
.   .. |||  ...   .   ..   .|.| .|  . .|. ||. . . .| .  .. ..  ||. .. |... .    |..|||
v...geelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHc
0044763 (Phosphotyrosine protein) phosphatases II 166-332 3.7e-20 67.8 In-house 2-118 (178) alignment 
Range on Protein: 166-332
Range on HMM: 2-118/178.0
YDHSRVVLEHHPS--GSDYINANYINGYdeksgSYIATQAPlastaNEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIegenvlkfssfeltll
.|..||.|.. .   .||||||..| ..      |.... |      ... ...|    .||.||. .|. ..||..|||..|                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eesvnehytirklsikmigsnekktvDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
                           ||... .| ||.|...  .|||...... ... .|| .|||.
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 166-302 3.1e-12 40.9 In-house 5-126 (130) alignment 
Range on Protein: 166-302
Range on HMM: 5-126/130.0
YDHSRVVlehhpsGSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKekchqYWPKSA-IE-GENVLKFSsfeLTLL
.. ||.       | .||||... |  ...  |. ||.||| |. .|| |. |.   |.|.|  . |.|.     ||| |  .|  |. .  .   ||  
fevsrlq......gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivt...ltdr

EESVNEHYTIRKLSIKMIGSNekKTVDQYHFTSWPNHGT
.|. | . .  . . ... |   ...  .. . ||  ||
defknikasnleiesdlnesh..qaltmfqisnwpsdgt
0046846 (Phosphotyrosine protein) phosphatases II 171-332 4.4e-26 87.1 In-house 3-117 (176) alignment 
Range on Protein: 171-332
Range on HMM: 3-117/176.0
VVLEHHPSGSDYINANYINGYDeksgsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaIEGENVlkfssfeltlleesvneh
..| ... ..||||||.| |.      .||||.|| .|  .|. |..|    ..|.||..|| .. ||..|||   .|....                  
lrllgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..................

ytirklsikmigsnekktvdQYHFTSWPNHGTPSSsGPLLEFMDIVQQKYAPYdGPMVVHCR
                    ||... || ||.|..   |||....... .    || .|||.
....................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCs
0051429 (Phosphotyrosine protein) phosphatases II 179-332 1.5e-30 102.1 In-house 3-158 (272) alignment 
Range on Protein: 179-332
Range on HMM: 3-158/272.0
GSDYINANYINGYdeksG------SYIATQAPLASTANEFWCMvWEKEAPVIVMLTNLVENDKEKCHQYWPKSAI-------EGENVLKFSSFELTLLEE
 |.||||....||    |       ......||  ||..|| . .|    .||.|....| ...||..|||   .       ...    .  . .|||.|
lsgyiNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

SVNEHYTIRKLSIKMI-GSNEKKTVDQYHFTSWPNHGTPSSSgpLLEFMDIVQQkyapyDGPMVVHCR
.. ..|..|.| .... . .|  .| ..|.|.|| ||.|...  |||.......     .||..|||.
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCs
0036282 (Phosphotyrosine protein) phosphatases II 179-332 1.2e-27 92.1 In-house 1-112 (174) alignment 
Range on Protein: 179-332
Range on HMM: 1-112/174.0
GSDYINANYINGYDEKSgSYIATQAPLAstaneFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegenvlkfssfeltlleesvnehytirklsi
|||||||......   .  .||.|.|||     || |..|    ..|||....|....||..|||                                   
gsdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

kmIGSNEKKTVDQYHFTSWPNHGTPSSSGpLLEFMDIVQQKYAP-YDGPMVVHCR
    . ..... ||... || ||.|..|  ||||...|.. ..   .||..|||.
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs
0043147 (Phosphotyrosine protein) phosphatases II 179-332 8.4e-24 79.6 In-house 4-108 (172) alignment 
Range on Protein: 179-332
Range on HMM: 4-108/172.0
GSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLvendkekchqywpksaiegenvlkfssfeltlleesvnehytirklsi
|||||||.|...|  .  ..||||.|| .| ..|| |..|.   .||.||.|                                                
gsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel................................................

KMIGSNEKKTVDQYHFTSWPNHGTPsSSGPLLEFMDIVQQ-KYAPYDGPMVVHCR
  ......... ||....|| ||.| ..  ||||......      .||..|||.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs
0051082 (Phosphotyrosine protein) phosphatases II 180-332 2.5e-19 64.8 In-house 3-100 (151) alignment 
Range on Protein: 180-332
Range on HMM: 3-100/151.0
SDYINANYINGYdeksgsYIATQAPLAstanEFWCMVWEKEAPVIVMLTNLVENDkeKCHQYWPKSAiegenvlkfssfeltlleesvnehytirklsik
|||||..|. |.      ......|||    .|. ...|    .||.|....|..  .|..|.|.                                   
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

migsnekKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQkyaPYDGPMVVHCR
        .| ......||..|.| |   .|||......   . .||..|||.
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 183-331 3.9e-25 83.2 In-house 78-221 (301) alignment 
Range on Protein: 183-331
Range on HMM: 78-221/301.0
INANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIegeNVLKFSSFELTLLEE--SVNEHYTIRKLSIKM
| ||.|.    ..  .||||.|| .|...|| |.   .   ||||.. ||. .|||..| | .     . |.   |.... ..   .|.. . |.| .. 
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis...ekldigrfkikiknkelilnkkiskrtleved

-IGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
  |  . .||  | ...|...|.| |   | ..|..|..     . |.||||
stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhc
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-244 1.4e-08 28.6 In-house 231-281 (440) alignment 
Range on Protein: 190-244
Range on HMM: 231-281/440.0
GYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLveNDKeKCHQYWPK
||  |  ..|||| || ||  .|| .| . .   |.|| .|  |||  |  ||| 
gyskk.nafiatqmpldstvldfwrlvhdyristiimlnql..ndk.tcsiywpv
0049260 (Phosphotyrosine protein) phosphatases II 197-332 2.6e-22 74.6 In-house 10-97 (152) alignment 
Range on Protein: 197-332
Range on HMM: 10-97/152.0
SYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWpksaiegenvlkfssfeltlleesvnehytirklsikmigsnekktvdQYHFTS
 .||||.|.  |...|| |..|  . .|||||.|.|..|.||.||.                                                ||... 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylhlp

WPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
|| ||.|..|  ||........ .   .|| .|||.
wpDhgvpdlsqlllflllfieklaldkggpvlVHCs
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 197-331 7.3e-15 49.7 In-house 5-141 (198) alignment 
Range on Protein: 197-331
Range on HMM: 5-141/198.0
SYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVLKFSSFELTLLEESVNEHYTIRKLSIKM--IGSNEKKTVDQYHF
 ||||| ||  |  .|| ||||  .  |||. .   | .     ||| .      . |..|. .|    ...  |||  | .          . . .| |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptte...sgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPNHGTPSSSGpLLEFM---DIVQQKYA-PYDGPMVVHC
||| .. ||  .  .. |.     | .||    | |..|||
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhc
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 197-331 7.4e-15 49.6 In-house 6-142 (199) alignment 
Range on Protein: 197-331
Range on HMM: 6-142/199.0
SYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVLKFSSFELTLLEESVNEHYTIRKLSIKM--IGSNEKKTVDQYHF
 ||||| ||  |  .|| ||||  .  |||. .   | .     ||| .      . |..|. .|    ...  |||  | .          . . .| |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptte...sgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPNHGTPSSSGpLLEFM---DIVQQKYA-PYDGPMVVHC
||| .. ||  .  .. |.     | .||    | |..|||
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhc
subfamily_hpo-7_pd Subfamily hpo-7 198-319 1.3e-11 38.9 In-house 40-154 (263) alignment 
Range on Protein: 198-319
Range on HMM: 40-154/263.0
YIAtqapLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksaIEGENVLKFSSFELTLLeeSVNEHYTIRKLSIKMIGS--NEKKTVDQYHFT
|.     |  | ..|. ..  ... |.|||..  |...||| .|.|   .| .. .|.   ...     | .   .. | .  . .   . .|| .| ..
ysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfP...lekdekqklanvnvctt..kvqsdvllktlellstlgeKkkthtvkhysyk

SWPNHGTPSSSGPLLEFMDIVQQK
 |...  |  .   |. ...... 
gWiekndpelareilnilkvarns
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 200-331 5e-14 46.4 In-house 95-228 (302) alignment 
Range on Protein: 200-331
Range on HMM: 95-228/302.0
ATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVLKFSSFELTLL--EESVNEH--------YTIRKLSIKMiGSNEKKTV
    |  || . .|... . .  ..| |...||....|| .|. .     ...|||  . .. .  .. ..|         ||.     |.  .. ||||
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv...ggelkfgrytvktvsvktdleeftdkksfklytveiknekk.kkkvkktv

DQYHFTSWPNHGTPSSSGPLLEFMDIVQQkyapYDGPMVVHC
|  .|..||.||.|  . . |. .   .     |   ..|||
dilafsawpdhGapkeaytaldilkfces....ykknvlvhc
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 200-331 4.1e-13 44.0 In-house 39-155 (255) alignment 
Range on Protein: 200-331
Range on HMM: 39-155/255.0
AtqaplasTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksaIEGENVLKFSSFELTLLEESVNehYTIRKLSIKMIGS--NEKKTVDQYHFTSW
        | ..|. ..  ... |.|||... |...|||..|.|   .| .. ||..  ..|  . | .    .| | |    .   . .||  |... |
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp...lekdeklkladvnvtttkssad..vvlrtleitstlgekkkthtvkhysykGW

PNHGTPSSSGPLLEFMDIVQQKyapydGPMVVHC
... .|  .  .|. . .|..       ..||||
ieknaPelareilnilkvvrds.....ksvvvhC
0048076 (Phosphotyrosine protein) phosphatases II 264-332 1.1e-09 33.6 In-house 21-89 (145) alignment 
Range on Protein: 264-332
Range on HMM: 21-89/145.0
EESVNEHYTIRK-LSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPyDGPMVVHCR
.    ... |.  |.. .  ....... ||....|| ||.|...  ||||...... ..  .||..|||.
dlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCs
0048179 (Phosphotyrosine protein) phosphatases II 269-332 7.7e-09 30.9 In-house 29-91 (144) alignment 
Range on Protein: 269-332
Range on HMM: 29-91/144.0
EHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApYDGPMVVHCR
 ..|.  |. .     ..... ||....||.||.|...  ||||...... ..  .||..|||.
gittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 277-331 4.4e-07 23.6 In-house 79-134 (440) alignment 
Range on Protein: 277-331
Range on HMM: 79-134/440.0
SIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIV-QQKYAPYDGPMVVHC
   .| . | .|. |||. .||..| |  .||.|.... | . .    .||..|||
nasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhc
PTPc_DSPc_SM00012 288-331 9.5e-10 34.0 In-house 1-46 (105) alignment 
Range on Protein: 288-331
Range on HMM: 1-46/105.0
TVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYD--GPMVVHC
|| .||.|.||.||.|..| ..||... |....   .  .|.||||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhC