Gene AquePTP-Un-4 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP046_AA protein Get Run
AqueP046_AA_115-332 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 106-332 2.2e-60 200.3 In-house 2-242 (307) alignment
Range on Protein: 106-332
Range on HMM: 2-242/307.0
EPEVKEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAP-----TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS---GSDYINANYI--------N
.......|.. .. ..| ... .  ... .|| .. . . .     .  . ..||..||. .| .|||.||.| . ..   .||||||.|.        .
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

GYDEkSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMI-GSNEKKT
|||  .  .||||.|| .| ..|| |.||.   ||||||.|||...|||.|||| .    . .| .  |  |||.|.. ..||.|.| ...  |..|  |
gydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde....geeltygnftvtllseehldgytvrtlevtdldgtgesrt

VDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA--PYDGPMVVHCR
| ..|.|.||.||.|.|  .||.|...|.. ..  | .||..|||.
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 106-331 9.1e-42 138.2 In-house 3-224 (297) alignment
Range on Protein: 106-331
Range on HMM: 3-224/297.0
EPEVKEPIPVIDFAKHVETmhNNQDYLFTEEFFRIePDH--APTRRATKN-NKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEksgSYIA
 |  ..|||. |||  |..  | .  .|.|||  . |     |.  | |. | |..|.  |  || ||| |.   .   |||.|| ...|. .    .|.
spkerrpiplsdfatlvqk..nrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlit

TQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSAIEGenvlkFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNH
|| |  .| ..|| ||..... .||||... |.|| || .||.....       | .  ..||  |  | .  |.|...   .  .. |.||.|..||..
tqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdk

GTPS--SSGPLLEFMDIVQQKYAPYDG-PMVVHC
  .   |   ||.... |....      |..|||
averkdsassllklisevrkdfsqnaegPllvhc

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 108-331 7e-55 181.4 In-house 4-230 (298) alignment
Range on Protein: 108-331
Range on HMM: 4-230/298.0
EVKEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHA-----PTRR-ATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDEKSgSYI
|.....  . . | .. .....   ...|| |..          ..   ...||..||. .| |.|.||||||.      |||||| ....|.... ..|
eieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afi

ATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenvlKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPN
|||||| .| ..|| ||.|... .|||||||.| || |.|.|||..  |     .. .....||.. .   ...||| ..   ......| | ||||||.
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.....tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpd

HGTPSSSGPLLEFMDIVQQkYAPYDG--PMVVHC
.|.|. .  .|.... |.. .    |  |..|.|
kgvpenatsvldllrkvra.sqqqagnkpvivqC

0050432 (Phosphotyrosine protein) phosphatases II 109-331 3.4e-68 225.6 In-house 22-239 (308) alignment
Range on Protein: 109-331
Range on HMM: 22-239/308.0
VKEPIPVIDFAKHVETmhNNQDYLFTEEFFRIEPDHA---PTRRATKNNKERNRFLSIAAYDHSRVVLehhPSGSDYINANYINGYD-EKSGSYIATQAP
......|.|..|..|    .. .|. |||...         .  . ..||..||. .| .||||||.|   ..|||||||.|..||.  ..  .||||.|
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgP

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAieGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPS
| .| . || |||| . .||||||.||||..|||.|||| .   |...|..  | .|||.| |...||.|.| ....|..| .|| ..|.|.||.||.|.
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel..gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

SSGPLLEFMDIVQQKYapYDGPMVVHC
|  .||.|...|....   .||.||||
speilldflelvrksl..pggpivVHC

subfamily_PTPRD_pd Subfamily PTPRD 110-331 4.5e-81 268.2 In-house 2-221 (564) alignment
Range on Protein: 110-331
Range on HMM: 2-221/564.0
KEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRAT--KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDeKSGSYIATQAPL
..|||| ....||. .. |.|. |.||. .||. .  | .|   . ||..||.  | |||||||||.. .  .|||||||..|.||. |. .|||||.||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

ASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiEgenVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSS
|.| ..|| ||||..  .|||||.|.|..|.|||.|||..  .     .. ... || ||   ..|.||....|.  |.|...| |.||||||.|| | |
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g...tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

SGPLLEFMDIVQQKYAPYDGPMVVHC
  .||.... |..   |  ||.||||
atslLdlirkvralnepdagPivVhC

subfamily_PTPRB_pd Subfamily PTPRB 110-331 2.5e-65 215.4 In-house 4-225 (293) alignment
Range on Protein: 110-331
Range on HMM: 4-225/293.0
KEPIPVIDFAKHVETMHNNQDYLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVL--EHHPSGSDYINANYINGYDEKSgSYIATQAP
..|| . .|..||..|....|. |.||. ..   . |.| .   .. |...||.  | .|||||| |   .. |||||||||||.||  .   .|||| |
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGP

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPS
| .| ..|| |||||.. .|||||.|||. |.||..|||.     |.   . . ..||..|.. |...||.|.|.   ..|...| ||||||||.|| |.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPe

SSGPLLEFMDIVQQKY--APYDGPMVVHC
.. .||.|.  |...   .  ..|.||||
ktktlldfvrtvreaiektaskrPivvhC

subfamily_PTPRA_pd Subfamily PTPRA 110-331 4.7e-55 181.8 In-house 11-235 (330) alignment
Range on Protein: 110-331
Range on HMM: 11-235/330.0
KEPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPD--HAPTRRATK-NNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAP
  |.|| .. . ..    ..  || |||  .     .|    |.| .|||.||.. |  ||.|||.| .      |||||| .|.|| ||  ..||.| |
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd.kfiaaqGP

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIG----SNEKKTVDQYHFTSWPNH
.. | ..|| |.||...  |||||.| | ..|||.||||.     | .. .    ... .| | ..||.||. .. ..     .... | |.||||||. 
keetvedfwrmiweqksativmltelkerkeekcaqywPd.....eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv

GTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
| |. .  .|...  |...   . ||.||||
GvPfepiGmlkllkkvkklnqqsagpivvhc

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 110-194 1.7e-11 38.2 In-house 3-89 (440) alignment
Range on Protein: 110-194
Range on HMM: 3-89/440.0
KEPIPVIDFAKHVETmhNNQDYLFTEEFFRIEP-DHAPTRRAT-KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEK
. || | ||| .|.   | .   | .|.  .      |. .|.  ||| .||. .| |||||||.||.      |||||| |||| . .
qrpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 111-331 2.2e-58 192.8 In-house 3-223 (319) alignment
Range on Protein: 111-331
Range on HMM: 3-223/319.0
EPIPVIDFAKHVETMHNNQDYLFTEEFFRIE-PDHAPTRRAT-KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAPLA
..|.| ............ . |. .||  .. ..   .. |. ..||..||.  | |||..|||| . .   |||||||..|.||.|..  .|||||||.
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPle

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSN-EKKTVDQYHFTSWPNHGTPSS
 | ..|| ||||.|. ..||||.|||. | |...|||.     ||. ..  . .||.||   |.| ||||...   |. | ..| ....|.||.|. | .
ntiedfWrmvWeeessivvmltklveklkvklkkywpe.....enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek

SGPLLEFMDIVQQKY-APYDGPMVVHC
.  ||...  ...    . .||.||||
atslldllkrirksrektqsgPivvhC

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 111-331 2.1e-38 126.7 In-house 2-176 (392) alignment
Range on Protein: 111-331
Range on HMM: 2-176/392.0
EPIPVIDFAKHVEtmHNNQDYLFTEEFFRI-EPDHAPTRRATK-NNKERNRFLSIAAYDHSRVVLE--HHPSGSDYINANYINGYDEKSgSYIATQAPLA
.|||| .|   ||  .| .  ||.|||. . .||  |.. | |  |...||.  |  || .||.||     . |||.|| ||...| .  .|||.|.| |
qpipvaqfpafve..knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek.ayiasqgpna

STANEFWCMVWEKEAPVIVMLTNLVENDkekchqywpksaiegenvlkfssfeltlleesvnehytirklsikmiGSNEKKTVDQYHFTSWPNHGTPSSS
.. ..|| ||.....  |.|.|.| | |                                                 ....|| |.||| ||... |  .
aslddfwrmvfqenvttiamvtklkegd...............................................kgddartvaqfhftewPdkdvpkht

GPLLEFMDIVQQKYAPYDGPMVVHC
  ||.|.  |. ..  |  |...||
ssllkfikevkadfGqythpliihc

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 111-202 1.3e-15 51.3 In-house 3-94 (95) alignment
Range on Protein: 111-202
Range on HMM: 3-94/95.0
EPIPVIDFAKHVETMHNNQDYLFTEEFFRIEPD--HAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHpSGSDYINANYINGYDEKSgSYIATQ
 || |  |  ||  || | |  | .||  |      . |  ... |  .|||| |  || .||||  .   |||||| ...||  |   |||.|
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk.rdsdyinacfvdgyarkn.cyiaaq

0051299 (Phosphotyrosine protein) phosphatases II 112-332 1.1e-68 227.2 In-house 4-227 (288) alignment
Range on Protein: 112-332
Range on HMM: 4-227/288.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAP---TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSGsYIATQAPLA
.|.| ...|.|.... |. ... ||| .. .  ..   .  . ..|.|.||. .| .||||||.| . ..  |||||||.||.||. |   .||||.|| 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlp

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMI----GSNEKKTVDQYHFTSWPNHGT
.| ..|| ||||.. .||||||.|||...|||.||||      ...|..  .  |||.| |...||.|.| .. .    |..|..|| ..|.|.||.||.
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
|.|  .||.|. .|....|. .||.||||.
pdspellldflrlvrkalasgggpvvVHCs

0043336 (Phosphotyrosine protein) phosphatases II 112-331 5.2e-63 208.4 In-house 1-217 (278) alignment
Range on Protein: 112-331
Range on HMM: 1-217/278.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRAT--KNNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEKSGsYIATQAPLAS
||.| |..|...... |  .|. .||...   . .|.. .  ..||..||. .| .||||||.|.. ..   ||||||.|..||. . . .||||.|| .
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpe

TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSG
| . || ||||   ..|||||.|||....||.||||      ...|..  |  |||.| ....||.|.| ... |..|..|| .||...|| ||.|.|  
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp......ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpesls

PLLEFMDIVQQKYAPYDGPMVVHC
.||.|. .|...... .||..|||
llldflkavrealedsngpvlVHC

0039614 (Phosphotyrosine protein) phosphatases II 112-331 8.9e-60 198.0 In-house 15-229 (297) alignment
Range on Protein: 112-331
Range on HMM: 15-229/297.0
PIPVIDFAKHVetMHNNQDYLFTEEFFRIE---PDhaPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPS---GSDYINANYINGYDEKSGSYIATQAPL
|. |.|.....  .. |. .|. .||...    ||   .  . ..||..||. .| .||||||.| . ..   .||||||.|..|||  .  .||||.||
plsvldlllll..ekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

ASTANEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSAIegenvlKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPSS
 .| . || ||||   .||||||.|||... ||.|||| .        ..  |  |||.. ....||.|.|....  ..| .|| ....|.|| ||.|.|
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvpps

SGPLLEFMDIVQQKYA--PYDGPMVVHC
.  ||||...|.. .|  | .||..|||
lellleflelvrealaelpkggpvlVHC

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 112-331 4.1e-57 188.7 In-house 3-223 (305) alignment
Range on Protein: 112-331
Range on HMM: 3-223/305.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTR-RATKNNKERNRFLSIAAYDHSRVVLEHHPSGS--DYINANYINGYDEKSgSYIATQAPLAST
.| . |.|.... .. ..|  . ...  .  .. ..    ...||..||. .|  .|..|. | ...|    |||||.|..||..|  .||..|.|| .|
iialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk.kyivaqgPlknt

ANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenVLKFSSFELTLLEESVNEHYTIRKLSIKM-IGSNEKKTVDQYHFTSWPNHGTPSSSG
 ..|| ...|    .|||||.|||..|.||.||||.|  |   . .| .|...| .|.  . |..|||.| .  ...|..|| ||..|.||.|| | ...
vadfWrliveekvstivmltklveggkdkCrqYWpeskte...kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PLLEFMDIVQQKYAPYDG-PMVVHC
 ||.... ||...    | |..|||
sllslikrvqkdqkkdkgvpllVhC

subfamily_Ptp69D_pd Subfamily Ptp69D 112-332 3.9e-54 178.9 In-house 3-227 (307) alignment
Range on Protein: 112-332
Range on HMM: 3-227/307.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPT---RRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAPLA
.|...| .. ... ... |.....|. ..|  . .      . |.|. .||.  | |.|. ||.|.. .    ||||||..|.||.||  ..|| |.|. 
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPve

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegeNVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-----SNEKKTVDQYHFTSWPNHG
.|...|| |..|.|  .||||.|| | ...||..|||.      .  .. .   .| .|.  ..|.||.|.. ...      .... | |||.|.|..  
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDsk

TPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
 | ..  ||.... |.. |    .|.||||.
vPevargllklieqvrelyklnrsPivvhCs

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 112-331 1.3e-51 170.3 In-house 2-217 (315) alignment
Range on Protein: 112-331
Range on HMM: 2-217/315.0
PIPVIDFAKHVEtmHNNQDYLFTEEFFRI-EPDHAPTRRA-TKNNKERNRFLSIAAYDHSRVVL---EHHPsGSDYINANYINGYDEKSgSYIATQAPLA
|||| .|   |.  .| .  ||.|||. . .||  ..| | ...| ..||.  |  .|..||.|   . .|  |||||| ||...|.   .|||.|.|| 
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsP.dsdyinasyiksvdddk.ayiasqgPlk

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiEGeNVLKFSSFELTLLEESVNEHYTIRKLsiKMIGSNEKKTVDQYHFTSWPNHGTPSSS
.. ..|| ||.....  |||.|.. |.|| || ||||.   .. .  .| |....||. . .   ..|||   .  |.|..|| |..|| ||..|..  .
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr..ka.dsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqt

GPLLEFMDIVQQKYAPYDGPMVVHC
. ||...  |. .  ... ...|||
ssllklikevkadngkkefsllvhc

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 112-332 1.8e-50 166.7 In-house 5-220 (315) alignment
Range on Protein: 112-332
Range on HMM: 5-220/315.0
PIPVIDFAKHVETMHNNQDYLFTEEFFRIEPDH-APTRRATK-NNKERNRFLSIAAYDHSRVVL--EHHPSGSDYINANYINGYDEKSgSYIATQAPLAS
|||. ..  .|   . .    | ...  |   .  | . | | .||..||.  | |||.||| |      ..|||.|||.|.||. |   |||.|.|...
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr.ryiaaqgpnva

TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegenVLKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPSSSG
. ..|| .|.|..   |||||||||..|.|. .|||         . .  . .|. .| ||..||.| ||. .   .. ..| |.|.||||. | | .. 
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk......kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkyti

PLLEFMDIVQQKYAPYDGPMVVHCR
||....  |.|      |..||||.
plmnlirtvkqhhtnsvgaivvhcs

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 112-331 3.6e-47 155.6 In-house 1-216 (515) alignment
Range on Protein: 112-331
Range on HMM: 1-216/515.0
PIPVIDFAKHVEtmHNNQDYLFTEEFFR-IEPDHAPTRRATK-NNKERNRFLSIAAYDHSRVVLE---HHPsGSDYINANYINGYDEKSgSYIATQAPLA
|.|. .|   |.  .|..  ||.|||     |.  |   | .  | ..||.  |  || .|| ||     |  |||.|| ||...|    .|||.|.|. 
plplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnP.hsdyfnasyipsfdndk.ayiasqgPnk

STANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAieGeNVLKFSSFELTLLEESVNEHYTIRKLsiKMIGSNEKKTVDQYHFTSWPNHGTPSSS
.. ..|| .|....   |.|.|.| |.|| || .|||.    | . .|| |... |.  .     ..|||  ... ... .|| |.||| ||..|.|  .
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp..g.dsvkfGsikvelvsleactggikrkl..tvlkgddsrtvtqfhfteWPdkGvpkht

GPLLEFMDIVQQKYAPYDGPMVVHC
  || ..  |. .   |  |...||
ssllklikevkadhgqythpliihc

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 113-331 1.6e-65 216.3 In-house 2-220 (318) alignment
Range on Protein: 113-331
Range on HMM: 2-220/318.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAP--TR-RATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDeKSGSYIATQAPLAS
|.| |...||. .... . |..||. |......   .    .. || .||.  | ||||.|| |..     ||||||||||.||  .. .|||.||||. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegeNVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSG
| ..|| ||||... ||||||...|. |.|.|.|||..     .  .. .   .| ||   ..|..|.....  ...|...| |||.||||..|.|.|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.....gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesga

PLLEFMDIVQQKY-APYDGPMVVHC
 ||...  |..    .  ||.||||
slldlvrqvskaqqksgagpivvhC

subfamily_PTPRG_pd Subfamily PTPRG 113-332 7.3e-65 214.2 In-house 1-228 (563) alignment
Range on Protein: 113-332
Range on HMM: 1-228/563.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPT----R-RATKNNKERNRFLSIAAYDHSRVVLEHHPS--GS-DYINANYINGYDeKSGSYIATQAP
.|| .|||||  .| ..|  |.|||  ..  ....         ..||..|| |.| |||.||| |.  |   .. ||||||||.||  ||  .|||| |
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

LASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGS------NEKKTVDQYHFTSWP
|..|.. || |.||... .|||.|||||. ..||..||||     ...... ....|| || |   ||.|.|.|| .        ...|.| |||.|.||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP

NHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
.||.|..| | | |.   ..      ||.||||.
dhgvPehslpvLifvkkssaankaeaGPivvHcs

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 113-331 5.4e-57 187.9 In-house 2-223 (290) alignment
Range on Protein: 113-331
Range on HMM: 2-223/290.0
IPVIDFAKHVETMHNNQDYLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSGSD----YINANYINGYDEKSgSYIATQAPL
||| .|...|.. | ...  | ..| ..   | .|. |.  |..||..|||  |  ||  |..| . ..  |    |||| ||.|| ||  .|||||.|.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekk.qyiatqgpv

ASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenVlkFSSFELTLLEESVNEHYTIRKLSIKMIGS-NEKKTVDQYHFTSWPNHG-TP
 .|. .|| ..|... ..|||||| .|..|.||.||||.|  .      .  |...||.|.. ..|..|||..|   | ..|..| ||..|.|...|  .
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtk...a..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvt

SSSGPLLEFMDIVQQKYAPYDGPMVVHC
  .. || .  ...... . ....||||
npqtillvieemyktqrkrgntsivvHC

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 113-331 1.7e-55 183.1 In-house 2-218 (287) alignment
Range on Protein: 113-331
Range on HMM: 2-218/287.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEP----DHAPTRRATKNNKERNRFLSIAAYDHSRVVLEhhPSGSDYINANYINGYDEKSgSYIATQAPLAST
|||  |.. |.. |.. .  |.. |  .|     ..  |   ...||..||.  |  .|  ||.|.      ||||| .|.|| ||   .|....|...|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekk.afiiaesPmfnt

ANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegeNvLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHG-TPSSS
| .||....... ..||||... |||.|.|.||||...    . . .  ....||.| ||..|..||| .|  . ...|..| ||..|.|...|  ..  
arnfWkliddrnvtaivmlcqekendeevcyqyWpeek....s.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq

GPLLEFMDIVQQKYAPYDGPMVVHC
  || . . ..... . ....||||
tillvieemyktqrkrgntsivvhC

subfamily_PTPRK_pd Subfamily PTPRK 113-331 2.5e-52 172.6 In-house 4-217 (314) alignment
Range on Protein: 113-331
Range on HMM: 4-217/314.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRatKNNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDeKSGSYIATQAPLASTAN
| | |  ... ... .. | | ||.  .      ...  ..|.|.||.  | |||.|||.|        ||||||..|..|  ..  .|.|| || .| .
irvadllqsiallkraegygfkeeyeslfegwdaakk..denreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvk

EFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEgenvlkFSSFELTLLEESVNEHYTIRKLSIKM--IGSNEKKTVDQYHFTSWPNHGTPSSSGP
.|| .|.....  |||||.|||. . || .|||. .        .  ....|.| .... . .| ....    | .|...| |..|..||.|..| |   
dfWrlvydencasivmltelvevgrvkClkyWPedtev......ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

LLEFMDIVQQKYAPYDGPMVVHC
||...  |... .. .|..||||
llklvrrvkksqeeeaGrivvhC

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 113-331 2.3e-42 140.3 In-house 5-228 (325) alignment
Range on Protein: 113-331
Range on HMM: 5-228/325.0
IPVIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTRRA--TKNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKsGSYIATQAPLAST
| |... .|||  . ...  |. ||  . .| . ....    .||..|||  . |.|.||||||     . ||||||.|.. . .|   ..|.||||..|
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltat

ANEFWCMVWEKEAPVIVMlTNLVENDKEKCHQYWPKSAieGeNVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGT---PSS
 |..| .| . ...|.|. .| ....|..| .||||    | .  .| ..|. |        |  |.| .| .   | ..| |... ||.. |.   |..
indlWrlvldWrcsvvvv.lneldlgkdrcavywpkem..g.ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpat

SGPLLEFMDIVQQKYAP---YDGPMVVHC
  ..|. .. |...        .|..|||
lisilqlvkavservtantkastpilvhc

0040438 (Phosphotyrosine protein) phosphatases II 115-331 1.6e-64 213.6 In-house 2-216 (317) alignment
Range on Protein: 115-331
Range on HMM: 2-216/317.0
VIDFAKHVETMHNNQDYLFTEEFFRIEPDHAPTR--RATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSGsYIATQAPLASTAN
| |. .......... ... |||...   . .|.   . ..||..||. .|  ||||||.| . ..  .||||||.|..|...|   .||||.|| .| .
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntve

EFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLL
 || ||||    ||||||.|.|...|||.||||      ...|..  |  |||.| .....|.|.| ..  |..|. || ..|.|.|| ||.|.|  .||
dFwrmvweqgvtvivmLteleelgrekcaqYwpl.....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdlll

EFMDIVQQKYAPYDGPMVVHC
.|...|...... .||..|||
dfleavrealedpggpvlVHC

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 117-331 4.2e-40 132.3 In-house 4-233 (301) alignment
Range on Protein: 117-331
Range on HMM: 4-233/301.0
DFAKHVETMHNNQdylFTEEFFRIEPDHAP--TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS----GSDYINANYINGYDEKSgSYIATQAPLASTAN
|  .|| ..|.|.   | |.. ...  .    |   ...||. ||| .|. ||. |..|...|.      .||||.||.|| ||   .||.|.|. .|  
dlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk.kfiaaqgpmkktlv

EFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEGENvlkFSSFELTLLEESVNEHYTIRKLSIKMI-GSN--------------EKKTVDQYHFT
.||...|..    |||.||| |. |.||.||||.|  | |.   |  |. || .| |   ..||.|..|.  |||              . ..| |.. |
dfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee...fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvt

SWPNHGT-PSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.||..|  .     |    |.....  .  ||.||||
dWpqdGvvreprtvLqviddvihrqqkigggpvvVHC

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 117-331 3.4e-38 126.2 In-house 6-219 (439) alignment
Range on Protein: 117-331
Range on HMM: 6-219/439.0
DFAKHVETMHNNQDYLFTEEFFRIE---PDHA--PTRRATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSgSYIATQAPLASTA
.| .||| ...|.. .|.|.|  |.   ||.|   .  | . .. .||. ...|.||.||.|.  |    | |||||||.|| ..   |||||.|   |.
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddk.lyiatqgpkkett

NEFWCMVWEKEAPVIVMLTNLVENDKekchqYWPKSAiegeNvLKFSSFELTLLEESVNEHYTIRKLSI--KMIGSNEKKTVDQYHFTSWPNHGTPSSSG
..|| .|.|| .  |||||||||  |     ||| .|    .   .    .    .    .|.|| . .  .   .. ..|| |.|...||..  |. . 
ddfwrlviekktvtivmltnlvesyk.....ywpsda....e.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas

PLLEFMDIVQQK-YAPYDGPMVVHC
 .|.|.  ..        ||.||||
hvldflrainsandkeeygpvvvhc

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 119-331 4.6e-57 188.3 In-house 3-215 (281) alignment
Range on Protein: 119-331
Range on HMM: 3-215/281.0
AKHVETMHNNQDYLFTEEFFRIEP-DHAPTRRATK--NNKERNRFLSIAAYDHSRVVL--EHHPSGSDYINANYINGYDEKSgSYIATQAPLASTANEFW
 ||......|..  |.||.  ..  .   | .|.|  .|...||.  | |||..||..  ... . .||||||...||...   |||||.|. .. ..||
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek.eyiatqgPvPaslvafW

CMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegeNVLKFSSFELTLLEESVNEHYTIRKLSIkMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFM
 ||||... .|||.|. .|..| |||.|||  .    . ||.. . .. ..|. ...|  ||...    |.|...| | ..|.||.|| |...  |||| 
qmvweqkvsaivmvtreieagklkChrYWPddn....selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefr

DIVQQKYAPY-DGPMVVHC
. |..   .  . |.|.||
kevlkltekktkaplvihC

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 119-331 8.4e-55 180.8 In-house 9-219 (288) alignment
Range on Protein: 119-331
Range on HMM: 9-219/288.0
AKHVETMHNNQDYLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDEKsGSYIATQAPLASTANEFW
 ..|  .. ..   |.||.  .   | ... |     .|...||.  | .||. || |..  . .|.|||||.||.|...|   |||||.|||.| |.||
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfW

CMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKmiGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFM
 .|.|...  |||||.|||..|.||..|||..    ..  .. |...||.|.   |... ||| ..   .... .. ||....||.|| | |. ||||..
elvyenktstivmltelveggktkCeeYWPda....dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllell

DIVQQKYAPYDGPMVVHC
..|..      ||..|||
rqvkvanqadtgpiivhC

subfamily_ptpA1_pd Subfamily ptpA1 120-317 2e-29 97.6 In-house 15-216 (418) alignment
Range on Protein: 120-317
Range on HMM: 15-216/418.0
KHVETMHNnqdylFTEEFFRIEPDHAPTR---RATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDEKsgSYIATQAPLASTANEFWC
.|.. .|.       |||  .|    |.       | |  .||.  |   .|.|| |..     ||||||||||.|   |   .|.|| ||  |  .|| 
nhikcihk.....ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwr

MVWEKEAPVIVMLTNLVENDKEKCHQYWPKS------AIEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGP
||||. . .||||.   || . || .|||.       .| |.    | .. . |.|   .    |    |..    | . . ||..  ||.|  |  . |
mvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqp

LLEFMDIVQ
. ...  . 
frqllhsit

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 125-312 1.2e-35 117.8 In-house 9-189 (297) alignment
Range on Protein: 125-312
Range on HMM: 9-189/297.0
MHNNQDYLFTEEffrIEPDHAPTRRATKnnKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDEKSG-SYIATQAPLASTANEFWCMVWEKEAPV
.....| |. |       . . ..| .     .||.  | |.| .|| |   ....|||||.|.   ||..   || .| || .| ..|| .|.|..  |
leaekdllldea...rgesfssakrnss..lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrv

IVMLTNLVENDKEKCHQYWPKSAIEGenvLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEF
|||...| |. ..||  |||..  |.   || ... .  | .  .|. ..    ...|  .|.. |    | |||.|| ||    |  |
ivmvaklqedGrdkcapywpsvvqer...lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 126-331 5.5e-39 128.8 In-house 4-206 (283) alignment
Range on Protein: 126-331
Range on HMM: 4-206/283.0
HNNQDYLFTEEFFRIE-PDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSgsDYINANYIN--GYDEKSGSYIATQAPLASTANEFWCMVWEKEAP
..|.  || | . |.  ||   .  ....||. ||.  | ..|  || |. ..   ||||| .|     ....  ||..|.||  |  .|| ||..... 
rvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

VIVMLTNLVENDKEKCHQYWPKsaiEGenVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKK-TVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA
 |||||.| |. ..|| |||||   .|    ..  | .|| .|  .. ..|..| ... .| ...  .  | .  | . |  .    |. |  .. ..  
aivmltklqedlrikCsqyWPk...rG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqte

PYDGPMVVHC
  .||.||||
skkgPivvhC

subfamily_PTPN14_pd Subfamily PTPN14 130-318 6.3e-39 128.8 In-house 23-214 (300) alignment
Range on Protein: 130-318
Range on HMM: 23-214/300.0
DYLFTeEFFRIEPDHAPT--R-RATKNNKERNRFLSIAAYDHSRVVLEH-HPSGSDYINANYING-YDEKSGSYIATQAPLASTANEFWCMVWEKEAPVI
  .|| |. || . .. .     . ..|.|.|||  .  |...|| |   . . ..||||  |.     |. |||..|.||  | ..|| ||||..  .|
gkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli

VMLTNLVENDKEKCHQYWPKSAIeGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQ
||||.  |. |||...|.||.    .. ..|  |..|    .  . .. ..| .| . |.|..||    .| ||.|| |.   . |.... || 
vmlteeeedgkeksfkyfPkles.kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

0036941 (Phosphotyrosine protein) phosphatases II 131-332 8.4e-64 211.0 In-house 13-215 (297) alignment
Range on Protein: 131-332
Range on HMM: 13-215/297.0
YLFTEEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLehHPSGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVML
.|. .|| ..    ..   .  . ..|.|.||. .| .|||.||.|  ...|||||||.|..||| |   .||||.|| .| ..|| ||||   .|||||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvml

TNLVENDKEKCHQYWPksaIEGENVLKFSSFELTLLEESV--NEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQ--KYAPY
|.|||...|||.||||    | ...|..  | .|||...|  ...||.|.| ....|..|..|| ..|.|.|| ||.|.|  .||.|.. |..  |..| 
telvelgrekcaqywp...leegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

DGPMVVHCR
.||..|||.
ggpvlVHCs

subfamily_PTPN6_pd Subfamily PTPN6 133-331 3.4e-57 188.8 In-house 28-234 (306) alignment
Range on Protein: 133-331
Range on HMM: 28-234/306.0
FTEEFFRI---EPDHAPTRRA--TKNNKERNRFLSIAAYDHSRVVL-EHHPSGSDYINANYIN-GYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIV
|.||| ..   |  .  .|.    ..|||.||. .|  .||.||.| |.. .||||||||||.    ... ||||||  | .| ..|| |||.... |||
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrviv

MLTNLVENDKEKCHQYWPKSAIEGEnvlkFSSFELTLLEESVNEHYTIRKLSIK-MIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYD
|.|. ||  |||| .|||..  . |    . . ..| ..|. ...|..|.||.. .  ..|...| ||||.|||.||.|.. | .|.|.. |..|.    
mttkevErgkekCarYWPdeeekee....yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

----GPMVVHC
    ||.||||
eaeagpivvhC

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 133-331 2.4e-52 172.7 In-house 7-208 (274) alignment
Range on Protein: 133-331
Range on HMM: 7-208/274.0
FTEEFFRIEPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSGS---DYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTN
...||. .  .. .       ....||. .|   ..|||.||.. | .   .||||||| ||||.|  |.||| ||..| ..|| |....|..||||||.
lekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LVENDKEKCHQYWPKSaIEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSneKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKY---APYDGP
| |....||..|.|.. .. |   ..  .|..  .   ...|..|||..|   .  ...|  | .|.||.| .| .  .||.... |...    .   .|
lkeaneqkCavyfPda.edyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklap

MVVHC
.||||
vvvhC

subfamily_PTPN3_pd Subfamily PTPN3 134-331 6.2e-53 174.5 In-house 21-215 (280) alignment
Range on Protein: 134-331
Range on HMM: 21-215/280.0
TEEFFRIEPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSgsDYINANYINGYDEK---SGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNL
 |...| .|. | .     .| ..||.  |..||. || |.. ..  |||||||.|   .    .  ||||| |||.||..|| ||||... .|||||.|
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VENDKEKCHQYWPKsaieGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVH
||. . |||||||.     |. |....|.... .|. .. | .|.| .|   ..|.... |  ...||.|| |..|  .|||.. |... .  . |.|||
verGrvkChqyWPe....tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

C
|
C

0047943 (Phosphotyrosine protein) phosphatases II 135-332 6e-63 208.2 In-house 16-213 (273) alignment
Range on Protein: 135-332
Range on HMM: 16-213/273.0
EEFFRI---EPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLehHPSGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLV
||| ..    |..  .  . ..||..||. .| .||||||.|  ...|||||||.|..||. |   .||||.|| .| ..|| ||||. ..||||||.||
eefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelv

ENDKEKCHQYWPKSaiEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP--YDGPMVV
|...|||.|||| .  .||..|..  |  |||.| ....||.|.| ....|..|..|| ..|.|.||.||.|.|  .||||...|.....    .||.||
elgrekcaqYwple..ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV

HCR
||.
HCs

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 138-331 5.5e-22 73.0 In-house 16-199 (267) alignment
Range on Protein: 138-331
Range on HMM: 16-199/267.0
FRIEPDHAP-TRRATKNNKERNRFLSIAAYDHSRVVLEHhpSGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDke
 .| ....  .   ...|.||||.     ||..||.|    .  .|||| |..||  |   .|.|| ||  |  .|. .. ... ||||.||.  ...  
kkisdtsstisqsiaeknqernrlddnlpyddtrvilrt..keeeyinasyvegyktkn.afivtqdplkntitdfltvihdqkvpvivlltkvftdn..

kCHQYWPKSAIEGEnvlKFSSFELTLLEESVNEHYTIRKLSIKMIgSNEKKTVDQYHFTSWPNHG-TPSSSGPLLEFmdIVQQKYAPYDGPMVVHC
  ...||    . .   |.  . .    |  .. | |  | .|.   .  . |  |..  |           ||.    . ...    . |.||.|
.irlfwPPkmgqak...kyqdltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgi..laknqlengnrPlvvac

subfamily_eak_pd Subfamily eak 139-305 7e-17 55.8 In-house 37-197 (332) alignment
Range on Protein: 139-305
Range on HMM: 37-197/332.0
RIEPDHAPTRRATKNNKERNrFLSIAAYDHSRVVLEHHPS-GSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEK
. ..  . .  |  .. .||  . |  ||.  | |         ||||  .  . |    || | ..  .    || || |. .| ||.| . ||.. ||
dyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

CHQYWPKsaiEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMigSNEKKTVDQYHFTSWPNHGTPSS
  .|.|.   .. ..|||  ....  |   .. .  |.| ...   || . |  |..  | .  .|  
sdkyfpd...ktreelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpky

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 139-302 2.5e-15 50.7 In-house 80-235 (244) alignment
Range on Protein: 139-302
Range on HMM: 80-235/244.0
RIEPDHAPTRRAT-KNNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKek
 | || .  . |   ||  .||  .   .| .|| | .   |  |||| .. |   ..  || || ||| |. .|| |. |.   |.|.|  . |.|.  
iirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede..

chqYWPKSaiegeNVLKFSSFELTLLEESVNEHYTIR--KLSIKMIGSNEKKTVDQYHFTSWPNHGT
   ||| |     . |..   ..|.     .|   |.  .| |.    . ....  .  . ||  ||
...ywpds.....eplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

subfamily_PTPN13_pd Subfamily PTPN13 140-331 5.4e-46 152.1 In-house 23-209 (273) alignment
Range on Protein: 140-331
Range on HMM: 23-209/273.0
IEPDHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSgsdYINANYING-YDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKC
. |    .   .|.||..||.  .  ||..|| |. . .   ||||..|.   ...  .|||.| ||  |...|| ||||..| ||.|.|. .|..| ||
lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

HQYWPKSAieGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApYDGPMVVHC
|.|||.|.  ....   . .|..||.    . ...|.| .| . |.| . | . .|..||.||.|||. .||.|.  |..      ||.||||
hrywPesk..nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhc

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 140-331 2.8e-21 70.8 In-house 27-211 (288) alignment
Range on Protein: 140-331
Range on HMM: 27-211/288.0
IEPDHAPTRRATK--NNKERNRFLSIAAYDHSRVVLEHHPsgSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEK
  |..|. . ...  .|  |.|.  .   | .|| |.  |    ||.|| .     |    | .|||| .| .|.| |. |..   ||||..|.|  |||
dspneasidiidsfianptrdryenlprcditrvklsddp..dfyiaanvvssakyk.rrlicaqaPlngtieelWkmllesdveyivmlcellekGkek

CHQYWPKSAIEGENVLKFssfeLTLLE---ESVNEHYTIRKLSIKMIGSNeKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVqqkyAPYDGPMVVHC
  .|.|    |   . ..     |      . ..   ..  | |.  | . |. | . |.  |...| | .  . | .....      .. |.|||.
saeyfPsklGekarigrl....ctvvkkkradidklvkvsllriskegee.kvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhs

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 141-331 7.2e-30 99.0 In-house 29-216 (307) alignment
Range on Protein: 141-331
Range on HMM: 29-216/307.0
EPDHAPTrRATKNNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQ
.|.  ..  | . | ..||.  . . |..|.|.. .   |||| |||. |   |   .|..| || .|  .||.|. ...   ..|| ...|  | ||.|
tpegvtv.eafsantdknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceq

YWPKSAI----EGENVLKFSSFELTLLEESvNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
|||         ||.    |  .|   . .  ..  |   ..|.  ... .|.... .. ||..|.|      ..... |. .      |.||||
ywpleegqklvfgeapntisvanlgakkla.pdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhc

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 143-331 5.7e-18 59.5 In-house 41-230 (310) alignment
Range on Protein: 143-331
Range on HMM: 41-230/310.0
DHAPTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSG-SDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQY
| . |  | |..  .||.  .   | ||| |.   |   ||| |||..    .| ..| .| ||  |  .|| |.... |  |..| . .|. . ||  |
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPKSAIEGenvlKFSSFELTLLEESVNEhYTIRKLSIKMIGSNE----------KKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
||   .       .    .| | || .| . | .|.. ..  |           .  |.  ..  ||. | |      .    . | .     || ||||
wpslgvte....tygcirvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr....hgpcvvhc





subfamily_egg_pd Subfamily egg 144-291 1.1e-23 78.4 In-house 29-176 (307) alignment
Range on Protein: 144-291
Range on HMM: 29-176/307.0
HAP-TRRATKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENdkEKCHQ
. . |. |..||.|. |   .   | ||| || .      |.| ||...|       .| .||||  | ..|| ||...| . |||||  .|.  |.|. 
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPKSAIEGENVlKFSSFELTLLE--ESVNEHYTIRKLSIkmIGSNEKK-TVDQ
||||.  .   .    |.... |.  .  .  ... || .  .|.....  .. 
ywpkaesdslvt.vpGslrienlkvdskadplfrvtklkl..vGgddeerfleh

DSPc_SM00195 145-331 1.2e-58 193.9 In-house 17-202 (263) alignment
Range on Protein: 145-331
Range on HMM: 17-202/263.0
APTRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYW
  |  . |.||..||.  |  |||.|| |.. .  .||||||||||.|. .|. .|||||.|| || ..|| ||||.. ..|||||. .||.||||..||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PKSAiegENVLKFSSFELTLLEESVNE-HYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
|...   ..  .| .....| |.   . ....|.|.... | .|...| ||....||.||.|.|  ..||..  |....   .||.||||
pees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

PTPc_SM00194 145-331 1.2e-58 193.9 In-house 17-202 (263) alignment
Range on Protein: 145-331
Range on HMM: 17-202/263.0
APTRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYW
  |  . |.||..||.  |  |||.|| |.. .  .||||||||||.|. .|. .|||||.|| || ..|| ||||.. ..|||||. .||.||||..||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PKSAiegENVLKFSSFELTLLEESVNE-HYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
|...   ..  .| .....| |.   . ....|.|.... | .|...| ||....||.||.|.|  ..||..  |....   .||.||||
pees...ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

subfamily_PTPRN_pd Subfamily PTPRN 145-331 1.3e-46 153.7 In-house 48-231 (297) alignment
Range on Protein: 145-331
Range on HMM: 48-231/297.0
APTRRAtKNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYW
. . .| ..| ..||  .. .|||||| |...   . ||||||  |   | .. .|||||.|||||  .|| ||||. . |||.||.| |.. ..|..||
kevaka.eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PKsaiEGENVlkFSSFELTLLEESV-NEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
|.   ||..|  .  .|. |. | .  . | .| . .| . ..| .|| |.|| |||..|.|.|. .||||   |.. |     |.||||
pd...eGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc

0046845 (Phosphotyrosine protein) phosphatases II 146-332 2.8e-64 212.6 In-house 20-212 (284) alignment
Range on Protein: 146-332
Range on HMM: 20-212/284.0
PTRRATKNNKERNRFLSIAAYDHSRVVLEHHPSG---SDYINANYINGYD----EKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKC
 .  . ..|...||. .| .||||||.| . ...   ||||||.|..|||     ..  .||||.|| .| ..|| ||||....||||||.||||..|||
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

HQYWPKSaiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA--PYDGPMVVHCR
.|||| .    ..||..  |  |||.| |...||.|.|.....| ..| .|| ..|.||||.||.|.|. .||||...|.. .   |..||.||||.
aqYwple....gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

0045098 (Phosphotyrosine protein) phosphatases II 146-332 6e-56 185.2 In-house 25-214 (278) alignment
Range on Protein: 146-332
Range on HMM: 25-214/278.0
PTRRATKNNKERNRFLSIAAYDHSRVVlehhpsgsDYINANYINGYdekSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKs
 |     .|...||. .| .||||||.        |||||.||.||   .  .||||.|| ||.. || |.||   .||||||.|||...|||.||||  
itpalylgnldknRykdilpydhsrVk........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

aiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMI----GSNEKKTVDQYHFTSWPNHGTPSSS--GPLLEFMDIVQQKYA-------------PYDGP
    ...| .  |..|||.|.|...||.|.| .  .     ..|. .| ..|...|| ||.||..   ..||... ... ..             . .||
....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

MVVHCR
..|||.
vlVHCs

subfamily_PTPN12_pd Subfamily PTPN12 146-331 1e-53 177.1 In-house 32-214 (290) alignment
Range on Protein: 146-331
Range on HMM: 32-214/290.0
PTRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWP
 .   ...|...||.  |  ||.|||.|...    ||||||||.|.| ..|  .|||.|.||. | ..|| |.|||.  ..||. ..||..| ||..|||
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

KsaiEGENVLKFSSFELTLLEE-SVNEHYTIRKLSIKMIgsNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.   |||. |.|..||.|| ||  |.. ..|| | ...   .|...| |.|.|.||.||.|||  .|||... |..     | |.||||
e...egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC

subfamily_PTPN1_pd Subfamily PTPN1 146-331 8.8e-50 164.0 In-house 23-208 (290) alignment
Range on Protein: 146-331
Range on HMM: 23-208/290.0
PTRRA-TKNNKERNRFLSIAAYDHSRVVLEHHPSgsDYINANYINgYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPK
||| | ...|...||.  .  |||||..||..    |||||. ..  .|   ||| || ||..|.. || ||||...  .||| ..||... ||.||||.
ptreaklpenrnlnryrdvspydhsrikleradn..dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

SAIEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQK--YAPYDGPMVVHC
   | | .|. ......|..| ....||.|.| .. . ..| ... ..|.|.||. | |.| . .|.|.  |..    ..  || |.||
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc

subfamily_PTPN9_pd Subfamily PTPN9 147-321 1.8e-51 169.9 In-house 35-207 (297) alignment
Range on Protein: 147-321
Range on HMM: 35-207/297.0
TRRATKNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPK
..  .. | |.||.  .  ||..||||.. .  . |||||||...|| .|  ..|||| ||  | ..|| ||||.|. |||| | .||. . || ||||.
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkk.afiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

saiEGENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA
   | |.. .|...... .|  ..|.|..|.| || .  .|...|  . |.|||..|.|||.  ||.... |..| |
...eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 147-331 4.1e-32 106.0 In-house 47-223 (290) alignment
Range on Protein: 147-331
Range on HMM: 47-223/290.0
TRRATKNNK--ERNRFLSIAAYDHSRVVLEHHPSGsDYINANYINGYDeksGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPK
 |.   .|   ..||.  ..  | .||.|.    | ||. |||..| .     .| || .|..|. ..| || .... .|||| .|.|. | ||.||.|.
erkifdkntefkknrykdvvcndktrvilkdGydG.dyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

SAieGEnVLKFSSFELTLLEESVN-EHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
 .  || || | .. ..  ||. . ..   . ||..   |  .. .  ..  |||..  . |.  ||  . |...      ||.||||
ke..Ge.vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhc

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 147-331 2e-23 77.7 In-house 28-210 (285) alignment
Range on Protein: 147-331
Range on HMM: 28-210/285.0
TRRATKNNKERNRFLSIAAYDHSRVVLEHHpsGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSA
|  | . | . ||.  . . . .||||. |    ||| |...    .   .||.|| ||  | ..|| |.....   ..||  |.|   |||  |.|.  
tytayeanpdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

ieGEnVLKFSSFELTLLEESVNEHYTIRKLSIKMIG----SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQqKYAPYDGPMVVHC
  || |.||  .|.|| |   .        .. .|     |.|   ... .   ||.. .|  . |..|.   |. |  | . |..|||
..ge.vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhc

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 149-309 8.2e-15 49.2 In-house 42-193 (303) alignment
Range on Protein: 149-309
Range on HMM: 42-193/303.0
RATKNNKERNRFLSIAAYDHSRVVLehhpSGSDYINANYINGYDEKsgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaie
.   .| ..|||  .   |||.| |    | | || |.|..   .|    | || ||. || .|| |. |.   ....|    | ||   .  .|.    
nqfvknmdknrfvdvicldhskvkl....sdssyihasyleldssk..kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn...

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPL
 .. |||    . . |    |     .| .  .   . |  .  .|. .||    || . | 
.qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspk

subfamily_PTPN23_pd Subfamily PTPN23 150-331 1.5e-50 166.7 In-house 39-219 (288) alignment
Range on Protein: 150-331
Range on HMM: 39-219/288.0
ATKNNKERNRFLSIAAYDHSRVVLEhhPSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAieg
. | . |.||.  |  |||.||.|.   |  ||||| ....    . ..|||||||.||.|.|| ||.|. ..|||||..  | .|.|...|||..    
iaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk...

ENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA----PYDGPMVVHC
..  ||  ...|| ..   |..  |.|.... .....|.|   ..||||..| |.| . ||.|.| |...|     . . |.||||
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

subfamily_CG7180_pd Subfamily CG7180 150-331 3.7e-34 112.7 In-house 38-230 (296) alignment
Range on Protein: 150-331
Range on HMM: 38-230/296.0
ATKNNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSAi
  |.|.|.||   .  ||. |||||.    . |||||| |....  |   || |.||  .| .||| .|...|.  .|.||.  .  | ....|||. . 
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

egenVLKFSSFELTLLEESVNEHYTIRKLSIKMI----------GSNEKKTVDQYHFTSWPN-HGTPSSSGPLLEFMDIVQQ---KY--APYDGPMVVHC
      ..  ... ..||    . .||.. ..             . |...| ....| |.  .  |.|.  |.|..  |..   |    |  ||.||..
....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs





0049772 (Phosphotyrosine protein) phosphatases II 150-332 3e-25 85.0 In-house 42-220 (314) alignment
Range on Protein: 150-332
Range on HMM: 42-220/314.0
ATKNNKERNRFLSIAAYDhSRVVLEHHP-SGSDYINANYINGYdeksGSYIATQAPLASTANEF----------WCMV--WEKEAPVIVM----------
    |...||.| |  .| .||.|   | ||||||||.|..|.     ..||||.||  | . |          | ||  ..    .|||          
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LTNLVENDkekchQ-----YWPKSAiegenvlkfssfeltlleesvnehytirklSIKMIGSNEKKTVDQYHFTSWPNHGTPsSSGPLL
           |..| .|            ...                                 ..   ..  .... .|. . .| ...| ..  ..
srLdaAlgKtpllildgng.....neptaadlellk..............................eelydpelferlgikylripvpDgsap.lledfd

EFMDIVQQKyaPYDGPMVVHCR
||......   . .|| .|||.
eflefieea..dkggpvlvHCk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 150-246 2.9e-08 27.5 In-house 47-142 (302) alignment
Range on Protein: 150-246
Range on HMM: 47-142/302.0
ATKNNKERNRFLSIAAYDHSRVVLEHHPsgSDYINANYINGYDEKsGSYIATQAPLASTA---NEFWCMVWEKEAPVIVMLTNLVENDKeKCHQYWPKSA
| |.| ..|.   . ..|. .| ||..|   .|.||  ..  . .  | | .| |  ...   .||| ||....   .|.|    | .|   ....|| .
afkknlkknqsedvpildsnlvkleaep..dsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks





0042113 (Phosphotyrosine protein) phosphatases II 151-332 5.7e-56 185.0 In-house 6-184 (245) alignment
Range on Protein: 151-332
Range on HMM: 6-184/245.0
TKNNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaie
 ..||..||. .| .|||.||.| ....   ||||||.|..||. . . .||||.||..| . || |.||    .|||||...|....||.||||     
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA-PYDGPMVVHCR
 ...|..  |  |||.| ....||.|.|.....|..|...| .||...|| ||.|...  ||.|...|.. .| . .||..|||.
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

0040439 (Phosphotyrosine protein) phosphatases II 151-331 1.1e-54 181.0 In-house 8-186 (249) alignment
Range on Protein: 151-331
Range on HMM: 8-186/249.0
TKNNKERNRFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaie
 ..||..||. .| .||||||.|.. |.  .||||||.||.||. |   .||||.|| .| . || |.||    ||||||.|||...|||.||||     
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYA--PYDGPMVVHC
 ...|..  |  |||.. |...||.|.| ..... .|. || ....|.|| ||.|.|  .||.|...|.. ..  | .||..|||
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHC

0037934 (Phosphotyrosine protein) phosphatases II 151-332 3.8e-54 179.1 In-house 7-186 (243) alignment
Range on Protein: 151-332
Range on HMM: 7-186/243.0
TKNNKERNRFLSIAAYDHSRVVLehhpSGSDYINANYINGYDeksgSYIATQAPLASTANE----FWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksa
 ..|...||. .| .||||||.|    .||||||||.|....     .||||.|| .| ..    || |.||    ||||||.|||...|||.||||   
lpenlsknrysdilpydhsrvkl....egsdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

iegENVlKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQK--------YAPYDGPMVVHCR
   ..|  .  |. |||.|.. ..||.|.|...... ......| .||...|| ||.|.|  .||.|.|.|..         ... .||..|||.
...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 151-331 2.3e-44 147.0 In-house 58-231 (319) alignment
Range on Protein: 151-331
Range on HMM: 58-231/319.0
TKNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTnlvendKEKCHQYWPKSAIE
 ..||..||.  | |.|...| ||.     .|||||| ...||  |   |||.| ||  | ..|| |.|| ..  ||.||      |.|| ||||. . .
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

GENVLKfssFELTLLEESVNehYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP--YDGPMVVHC
 |.  |    .....||. .  |..|.. .   |  .... . |.||  ||..| | .. .|. ... |.          ..||||
keerfk...vkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 151-331 4.4e-24 79.7 In-house 52-228 (305) alignment
Range on Protein: 151-331
Range on HMM: 52-228/305.0
TKNNKERNRFLSIAAYDHSRVVLEhHPSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIEGE
.. .. .||.  . . |.| | |. .|| |||| |||.         .|..| ||  | .||| || ..    |||| . ||  | || |||| .  |  
adiaitknryqdvpcqdqsavkld.kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

NVLKFSSFELTLLEESVNEHYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApydgPMVVHC
..      |       ..    |.   ...    ..| .| . ..| ||. | |      ||..  ..        |.||||
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhc

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 152-331 4.4e-51 168.5 In-house 7-182 (250) alignment
Range on Protein: 152-331
Range on HMM: 7-182/250.0
KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEkCHQYWPKsaieg
 .|||.||.  | |.|.||||||..     |||||| ...||||.  ..||||.|| .| ..|| ||.|... .|||||||.|..|. .|||||      
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.....

ENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP-YDGPMVVHC
|.  |. .  ..||.. .   ||.||| .     .....| |.||..||. | |      ||... ||..     ..|..|.|
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 152-331 2.2e-44 146.4 In-house 6-181 (239) alignment
Range on Protein: 152-331
Range on HMM: 6-181/239.0
KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIeg
. || .||.  | .|||||||||.      ||||||.|.  ||    .|||||  .. .. .|| |.|..   |||||| |.|  |.||||||| |.   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

envlKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
    |.  . .|| .  |   | || . .  .|  |.. | ||||| ||..| |  .  .| .   . .   |   | |.||
....kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 152-331 2.4e-44 146.3 In-house 5-180 (239) alignment
Range on Protein: 152-331
Range on HMM: 5-180/239.0
KNNKERNRFLSIAAYDHSRVVLEHHP--SGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIeg
. || .||.  | .|||||||||.      ||||||.|.  ||    .|||||  .. .. .|| |.|..   |||||| |.|  |.||||||| |.   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

envlKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
    |.  . .|| .  |   | || . .  .|  |.. | ||||| ||..| |  .  .| .   . .   |   | |.||
....kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 152-331 6.9e-44 145.4 In-house 23-195 (284) alignment
Range on Protein: 152-331
Range on HMM: 23-195/284.0
KNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSgSYIATQAPLASTANEFWCMVWEKEAPVIVMLTnlvendKEKCHQYWPKSAIEG
..||..||.  | |.|...| ||.     .|||||| .|.||  |   ||||| ||  | ..|| |.|| ..  ||.||      |.|| ||||. . . 
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

ENVLKfssFELTLLEESVNehYTIRKLSIKMIG-SNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAP--YDGPMVVHC
|.  |    .....||| .  |..|.. .   |  ...... |.||  ||..| | .. .|. ... |.          ..||||
eerfk...vkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 152-331 2.9e-42 139.5 In-house 18-204 (270) alignment
Range on Protein: 152-331
Range on HMM: 18-204/270.0
KNNKERNRFLSIAAYDHSRVVLEHH--PSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsAIEG
 ..|. ||.  |    ..||.||.    | . ||||||..|.|... .|||...||..| ..|| |.||.... |||.|.|.|. ..|| .|||.   . 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa.epke

ENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNeKKTVdQYHFTSWPNHGTPSSSG------PLLEFMDIVQQKYAPY--DGPMVVHC
.  |..   . . |.|. .| | ...| ..  |.. .. |  .....||.|| |....       ||. .  |..        .|..|||
kvkledgkikvlalseekeegyiltrlrleekgee.rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 152-331 7.6e-27 88.7 In-house 35-207 (281) alignment
Range on Protein: 152-331
Range on HMM: 35-207/281.0
KNNKERNRFLSIAAYDHSRVVLEH---HPSGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAie
  |...||.| | . | ||| |.        .||| ||||     | | || || |   |  .|| |.|....  |||| ...| ..||| .|.|. |  
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg.yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..

gENVLKFSSFELTLLEESVNEHYTIRKLSIKMIGsnEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
   .|.|  . ..  . .||.     .| .   |  | . . .. .  ||.   | ||  .|. .  .. .      | |.||
.hcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkirar....stppvihc

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 152-241 1.9e-13 44.6 In-house 32-121 (332) alignment
Range on Protein: 152-241
Range on HMM: 32-121/332.0
KNNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDEKSgSYIATQAPLAS-TANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQY
 || . ||   . ..||||| |  .    |. ||....|| .|| .|| .|||.   |   || || |..  .|... .. |..| |.   
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskks.ayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 153-331 7.9e-48 157.7 In-house 2-179 (237) alignment
Range on Protein: 153-331
Range on HMM: 2-179/237.0
NNKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegENV
.|| .||. .| |||||||||.   ||||||||.|..|.|    .|||.| || |. ..|| |||..   |||||| |.|....|||.|||..    .. 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst....dqp

LKFSSFELTLLEESVNEHYTIRKLSIKMI-GSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMD-IVQ-QKYAPYDGPMVVHC
  .  . ..|  .     ||.| | . .    .| . . ||.|||||..| |  .  || |   |..  .. .  || ..||
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 153-331 8.5e-40 131.3 In-house 37-217 (287) alignment
Range on Protein: 153-331
Range on HMM: 37-217/287.0
NNKERNRFLSIAAYDHSRVVLEHHP-SGSDYINANYINGYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSaiegEN
 . ..||.  .  .|..||.| ...  |||||||||. .| ..  ..||.|.|.|.| ..||..|.|... .....|  ||. . ||..|||.     | 
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer....ev

VLKFSSFELTLLEESVNE-HYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIV-----QQKYAPYDGPMVVHC
 ..   . ..||. .. | .|..| | .  . ..| . | |... |||... . ..  |. |.  |      .. |   ||.|||.
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

subfamily_CG42327_pd Subfamily CG42327 153-314 3.4e-35 116.2 In-house 27-188 (319) alignment
Range on Protein: 153-314
Range on HMM: 27-188/319.0
NNKERNRFLSIAAYDHSRVVLEHHPSG--SDYINANYINGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiEGE
  |...|.. .    ..||||.. ..   . |..|.|. |||.   ||||.|..| ... .|| .|||. . ||| ||.| |.  ..| .|.| ..  ..
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke.tld

NVLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKTVDQYHFtSWPNHGTPSSSGPLLEFMD
|   .  . .|| .  |...| |  | .| .  .| . .  | .  |.. . |..  .|.  . 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 153-331 7.7e-27 88.8 In-house 47-226 (305) alignment
Range on Protein: 153-331
Range on HMM: 47-226/305.0
NNKERNRFLSIAAYDHSRVVLeHHPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSA---IE-
.....||.  .   |. || | . |   .|| |||.     ..  .| |||||  |  .|| | ...    | || ||.|   .||..|..      .| 
qeagknrykdvgcldnnrvkl.egpwpheyihanyvstpt.npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

---GEN-VLKFSSFELTLLEESVNEHYTIRKLSIKMIGSNEKKtVDQYHFTSWPNHGTPSSSGPLLEFMdivqQKYAPYDGPMVVHC
   |.  ..|| | .   .... . . |  .| |.  |.. .| | .||.  ||. | |..   .||..    .|  |  ||.||||
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekark.vthyhwidwpdrgvpaadlailell....ekarpskgpivvhc

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 153-331 1.7e-16 54.8 In-house 42-216 (312) alignment
Range on Protein: 153-331
Range on HMM: 42-216/312.0
NNKERNRFLSIAAYDHSRVVLEHHpsGSDYINANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKS----AIE
. |. ||.  |  .|  |  |        || ||...    |   ...||.|| .|.  || ..    .  |..|. .||.  ||| .|         .|
kfkdlnrypniqcwdrgrftlagd..enfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

GENVLKFSSFELTLLEESVnEHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApydgPMVVHC
   |   .  |. .   |  .. | | | . .  . ..  ...| ..|||.|| | |    | ..  |..       |.. ||
dhrvyteycteieiggksk.dkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahc

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 153-226 1.7e-07 25.1 In-house 36-115 (347) alignment
Range on Protein: 153-226
Range on HMM: 36-115/347.0
NNKERNRFLSIAAYDHSRVVLEHHP-------SGSDYINANYINgYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVM
.. ..||       | .||||               |||| .|. .|. |  || || || .|  .|| ||       .| 
kslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 153-244 2.6e-06 20.5 In-house 26-86 (169) alignment
Range on Protein: 153-244
Range on HMM: 26-86/169.0
NNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINAnyingydeksgsyiatqaplastanefwCMVWEKEAPVIVMLTNlvENDKEkchQYWPK
 |. .||  .  |  | || |..  .  |||||||                             |.|| .| |||.| .   .||.   ..||.
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgd..tddkn...nfwpe

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 153-244 3.4e-06 20.0 In-house 25-85 (169) alignment
Range on Protein: 153-244
Range on HMM: 25-85/169.0
NNKERNRFLSIAAYDHSRVVLEH--HPSGSDYINAnyingydeksgsyiatqaplastanefwCMVWEKEAPVIVMLTNlvENDKEkchQYWPK
 |. .||  .  |  | || |..     |||||||                             |.|| .| |||.| .   .||.   ..||.
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGd..tddkn...nfwpe

Y_phosphatase Protein-tyrosine phosphatase 154-331 3.3e-58 192.3 Pfam-A 1-177 (235) alignment
Range on Protein: 154-331
Range on HMM: 1-177/235.0
NKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVL
||..||. .| .||..|| |..... ||||||||..||. .. ..||||.|| || ..|| |||...  ||||||.|.|...|||.||||..    |. |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee...eesl

KFSSFELTLL-EES-VNEHYTIRKLSIKMIGSN-EKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.. .....|  .|.  ...||.|||..|  ... ||..| |.|.|.||.||.|.|. .||.... |... .. .||.||||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC

Y_phosphatase Protein-tyrosine phosphatase 154-331 3.3e-58 192.3 In-house 1-177 (235) alignment
Range on Protein: 154-331
Range on HMM: 1-177/235.0
NKERNRFLSIAAYDHSRVVLEHHPSGSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVL
||..||. .| .||..|| |..... ||||||||..||. .. ..||||.|| || ..|| |||...  ||||||.|.|...|||.||||..    |. |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee...eesl

KFSSFELTLL-EES-VNEHYTIRKLSIKMIGSN-EKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHC
.. .....|  .|.  ...||.|||..|  ... ||..| |.|.|.||.||.|.|. .||.... |... .. .||.||||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC

0041856 (Phosphotyrosine protein) phosphatases II 154-332 1.7e-29 98.1 In-house 1-117 (182) alignment
Range on Protein: 154-332
Range on HMM: 1-117/182.0
NKERNRFLSIAAYDHSRvvlehhpsGSDYINANYINGYDEKSGsYIATQAPLASTANEFWCMVWEKEAPVIVMLTnlvendkekCHQYWPksaiegenvl
|...||.  |  |||||        ..||||||.. |.   .  .||||.|| || ..|. |..|    .||.||         ...|||          
nldknrysdilpydhsr........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

kfssfeltlleesvnehytirklsikmigSNEKKTVDQYHFTSWPNHGTPSsSGPLLEFMDIVQQkyapYDGPMVVHCR
                             ....... ||....|| ||.|.    ||.|...|..     .|| .|||.
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCs

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 156-254 6.4e-28 92.5 In-house 49-162 (350) alignment
Range on Protein: 156-254
Range on HMM: 49-162/350.0
ERNRFLSIAAYDHSRVVLE----------HHPSGSDYINANYINGY----DEKSGS-YIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQ
 .||.  |  |.|||| |.          |  |..|||||||..      . ...  |||||||| || ..|. .. . . .||..||..||.. |||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPKSAIEGENVLK
||.. .... .|  
YWqegsydditvkl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 156-252 4.4e-15 49.8 In-house 50-163 (349) alignment
Range on Protein: 156-252
Range on HMM: 50-163/349.0
ERNRFLSIAAYDHSRVVLEHHPSG----------------SDYINANYINGYD-EKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKC
 .||.  |  |.||||.|.. .                   |||||||..    .    |||||||| || ..|. ..  .. .... |..  |.. |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPKSAIEGENV
..|| . . .. .|
diywqelsysnitv

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 159-331 5e-16 53.7 In-house 23-198 (290) alignment
Range on Protein: 159-331
Range on HMM: 23-198/290.0
RFLSIAAYDHSRVVLEHHPS--GSDYINANYINGYDEKsgSYIATQAPLA-------STANEFWCMVWEKEAPVIVMLTNLVENDKE----KCHQYWPKS
. |...   ..||||. . .   .||| ||..   .      |.||.|..       || ..|| |. . ..  .||| .  |....     | .| |.|
qRlevpLveatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

AiegENVLKFSSFELTLLEESVNEHYTIRKLSIKMiGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApydgPMVVHC
.   .. |||  ...   .   ..   .|.| .|  . .|. ||. . . .| .  .. ..  ||. .. |... .    |..|||
v...geelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHc

0044763 (Phosphotyrosine protein) phosphatases II 166-332 3.7e-20 67.8 In-house 2-118 (178) alignment
Range on Protein: 166-332
Range on HMM: 2-118/178.0
YDHSRVVLEHHPS--GSDYINANYINGYdeksgSYIATQAPlastaNEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIegenvlkfssfeltll
.|..||.|.. .   .||||||..| ..      |.... |      ... ...|    .||.||. .|. ..||..|||..|                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eesvnehytirklsikmigsnekktvDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
                           ||... .| ||.|...  .|||...... ... .|| .|||.
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 166-302 3.1e-12 40.9 In-house 5-126 (130) alignment
Range on Protein: 166-302
Range on HMM: 5-126/130.0
YDHSRVVlehhpsGSDYINANYInGYDEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKekchqYWPKSA-IE-GENVLKFSsfeLTLL
.. ||.       | .||||... |  ...  |. ||.||| |. .|| |. |.   |.|.|  . |.|.     ||| |  .|  |. .  .   ||  
fevsrlq......gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivt...ltdr

EESVNEHYTIRKLSIKMIGSNekKTVDQYHFTSWPNHGT
.|. | . .  . . ... |   ...  .. . ||  ||
defknikasnleiesdlnesh..qaltmfqisnwpsdgt

0046846 (Phosphotyrosine protein) phosphatases II 171-332 4.4e-26 87.1 In-house 3-117 (176) alignment
Range on Protein: 171-332
Range on HMM: 3-117/176.0
VVLEHHPSGSDYINANYINGYDeksgsYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaIEGENVlkfssfeltlleesvneh
..| ... ..||||||.| |.      .||||.|| .|  .|. |..|    ..|.||..|| .. ||..|||   .|....                  
lrllgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..................

ytirklsikmigsnekktvdQYHFTSWPNHGTPSSsGPLLEFMDIVQQKYAPYdGPMVVHCR
                    ||... || ||.|..   |||....... .    || .|||.
....................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCs

0051429 (Phosphotyrosine protein) phosphatases II 179-332 1.5e-30 102.1 In-house 3-158 (272) alignment
Range on Protein: 179-332
Range on HMM: 3-158/272.0
GSDYINANYINGYdeksG------SYIATQAPLASTANEFWCMvWEKEAPVIVMLTNLVENDKEKCHQYWPKSAI-------EGENVLKFSSFELTLLEE
 |.||||....||    |       ......||  ||..|| . .|    .||.|....| ...||..|||   .       ...    .  . .|||.|
lsgyiNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

SVNEHYTIRKLSIKMI-GSNEKKTVDQYHFTSWPNHGTPSSSgpLLEFMDIVQQkyapyDGPMVVHCR
.. ..|..|.| .... . .|  .| ..|.|.|| ||.|...  |||.......     .||..|||.
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCs

0036282 (Phosphotyrosine protein) phosphatases II 179-332 1.2e-27 92.1 In-house 1-112 (174) alignment
Range on Protein: 179-332
Range on HMM: 1-112/174.0
GSDYINANYINGYDEKSgSYIATQAPLAstaneFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKsaiegenvlkfssfeltlleesvnehytirklsi
|||||||......   .  .||.|.|||     || |..|    ..|||....|....||..|||                                   
gsdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

kmIGSNEKKTVDQYHFTSWPNHGTPSSSGpLLEFMDIVQQKYAP-YDGPMVVHCR
    . ..... ||... || ||.|..|  ||||...|.. ..   .||..|||.
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

0043147 (Phosphotyrosine protein) phosphatases II 179-332 8.4e-24 79.6 In-house 4-108 (172) alignment
Range on Protein: 179-332
Range on HMM: 4-108/172.0
GSDYINANYINGYDeKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLvendkekchqywpksaiegenvlkfssfeltlleesvnehytirklsi
|||||||.|...|  .  ..||||.|| .| ..|| |..|.   .||.||.|                                                
gsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel................................................

KMIGSNEKKTVDQYHFTSWPNHGTPsSSGPLLEFMDIVQQ-KYAPYDGPMVVHCR
  ......... ||....|| ||.| ..  ||||......      .||..|||.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs

0051082 (Phosphotyrosine protein) phosphatases II 180-332 2.5e-19 64.8 In-house 3-100 (151) alignment
Range on Protein: 180-332
Range on HMM: 3-100/151.0
SDYINANYINGYdeksgsYIATQAPLAstanEFWCMVWEKEAPVIVMLTNLVENDkeKCHQYWPKSAiegenvlkfssfeltlleesvnehytirklsik
|||||..|. |.      ......|||    .|. ...|    .||.|....|..  .|..|.|.                                   
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

migsnekKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQkyaPYDGPMVVHCR
        .| ......||..|.| |   .|||......   . .||..|||.
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCs

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 183-331 3.9e-25 83.2 In-house 78-221 (301) alignment
Range on Protein: 183-331
Range on HMM: 78-221/301.0
INANYINGYdEKSGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAIegeNVLKFSSFELTLLEE--SVNEHYTIRKLSIKM
| ||.|.    ..  .||||.|| .|...|| |.   .   ||||.. ||. .|||..| | .     . |.   |.... ..   .|.. . |.| .. 
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis...ekldigrfkikiknkelilnkkiskrtleved

-IGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKyapyDGPMVVHC
  |  . .||  | ...|...|.| |   | ..|..|..     . |.||||
stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhc

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-244 1.4e-08 28.6 In-house 231-281 (440) alignment
Range on Protein: 190-244
Range on HMM: 231-281/440.0
GYDEKsGSYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLveNDKeKCHQYWPK
||  |  ..|||| || ||  .|| .| . .   |.|| .|  |||  |  ||| 
gyskk.nafiatqmpldstvldfwrlvhdyristiimlnql..ndk.tcsiywpv

0049260 (Phosphotyrosine protein) phosphatases II 197-332 2.6e-22 74.6 In-house 10-97 (152) alignment
Range on Protein: 197-332
Range on HMM: 10-97/152.0
SYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWpksaiegenvlkfssfeltlleesvnehytirklsikmigsnekktvdQYHFTS
 .||||.|.  |...|| |..|  . .|||||.|.|..|.||.||.                                                ||... 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylhlp

WPNHGTPSSSGPLLEFMDIVQQKYAPYDGPMVVHCR
|| ||.|..|  ||........ .   .|| .|||.
wpDhgvpdlsqlllflllfieklaldkggpvlVHCs

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 197-331 7.3e-15 49.7 In-house 5-141 (198) alignment
Range on Protein: 197-331
Range on HMM: 5-141/198.0
SYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVLKFSSFELTLLEESVNEHYTIRKLSIKM--IGSNEKKTVDQYHF
 ||||| ||  |  .|| ||||  .  |||. .   | .     ||| .      . |..|. .|    ...  |||  | .          . . .| |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptte...sgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPNHGTPSSSGpLLEFM---DIVQQKYA-PYDGPMVVHC
||| .. ||  .  .. |.     | .||    | |..|||
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhc

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 197-331 7.4e-15 49.6 In-house 6-142 (199) alignment
Range on Protein: 197-331
Range on HMM: 6-142/199.0
SYIATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVLKFSSFELTLLEESVNEHYTIRKLSIKM--IGSNEKKTVDQYHF
 ||||| ||  |  .|| ||||  .  |||. .   | .     ||| .      . |..|. .|    ...  |||  | .          . . .| |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptte...sgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPNHGTPSSSGpLLEFM---DIVQQKYA-PYDGPMVVHC
||| .. ||  .  .. |.     | .||    | |..|||
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhc

subfamily_hpo-7_pd Subfamily hpo-7 198-319 1.3e-11 38.9 In-house 40-154 (263) alignment
Range on Protein: 198-319
Range on HMM: 40-154/263.0
YIAtqapLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksaIEGENVLKFSSFELTLLeeSVNEHYTIRKLSIKMIGS--NEKKTVDQYHFT
|.     |  | ..|. ..  ... |.|||..  |...||| .|.|   .| .. .|.   ...     | .   .. | .  . .   . .|| .| ..
ysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfP...lekdekqklanvnvctt..kvqsdvllktlellstlgeKkkthtvkhysyk

SWPNHGTPSSSGPLLEFMDIVQQK
 |...  |  .   |. ...... 
gWiekndpelareilnilkvarns

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 200-331 5e-14 46.4 In-house 95-228 (302) alignment
Range on Protein: 200-331
Range on HMM: 95-228/302.0
ATQAPLASTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPKSAiegENVLKFSSFELTLL--EESVNEH--------YTIRKLSIKMiGSNEKKTV
    |  || . .|... . .  ..| |...||....|| .|. .     ...|||  . .. .  .. ..|         ||.     |.  .. ||||
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv...ggelkfgrytvktvsvktdleeftdkksfklytveiknekk.kkkvkktv

DQYHFTSWPNHGTPSSSGPLLEFMDIVQQkyapYDGPMVVHC
|  .|..||.||.|  . . |. .   .     |   ..|||
dilafsawpdhGapkeaytaldilkfces....ykknvlvhc

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 200-331 4.1e-13 44.0 In-house 39-155 (255) alignment
Range on Protein: 200-331
Range on HMM: 39-155/255.0
AtqaplasTANEFWCMVWEKEAPVIVMLTNLVENDKEKCHQYWPksaIEGENVLKFSSFELTLLEESVNehYTIRKLSIKMIGS--NEKKTVDQYHFTSW
        | ..|. ..  ... |.|||... |...|||..|.|   .| .. ||..  ..|  . | .    .| | |    .   . .||  |... |
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp...lekdeklkladvnvtttkssad..vvlrtleitstlgekkkthtvkhysykGW

PNHGTPSSSGPLLEFMDIVQQKyapydGPMVVHC
... .|  .  .|. . .|..       ..||||
ieknaPelareilnilkvvrds.....ksvvvhC

0048076 (Phosphotyrosine protein) phosphatases II 264-332 1.1e-09 33.6 In-house 21-89 (145) alignment
Range on Protein: 264-332
Range on HMM: 21-89/145.0
EESVNEHYTIRK-LSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPyDGPMVVHCR
.    ... |.  |.. .  ....... ||....|| ||.|...  ||||...... ..  .||..|||.
dlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCs

0048179 (Phosphotyrosine protein) phosphatases II 269-332 7.7e-09 30.9 In-house 29-91 (144) alignment
Range on Protein: 269-332
Range on HMM: 29-91/144.0
EHYTIRKLSIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYApYDGPMVVHCR
 ..|.  |. .     ..... ||....||.||.|...  ||||...... ..  .||..|||.
gittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCs

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 277-331 4.4e-07 23.6 In-house 79-134 (440) alignment
Range on Protein: 277-331
Range on HMM: 79-134/440.0
SIKMIGSNEKKTVDQYHFTSWPNHGTPSSSGPLLEFMDIV-QQKYAPYDGPMVVHC
   .| . | .|. |||. .||..| |  .||.|.... | . .    .||..|||
nasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhc

PTPc_DSPc_SM00012 288-331 9.5e-10 34.0 In-house 1-46 (105) alignment
Range on Protein: 288-331
Range on HMM: 1-46/105.0
TVDQYHFTSWPNHGTPSSSGPLLEFMDIVQQKYAPYD--GPMVVHC
|| .||.|.||.||.|..| ..||... |....   .  .|.||||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhC