Gene AquePTP-Un-5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP047_AA protein Get Run
AqueP047_AA_281-485 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 269-484 5.4e-44 145.5 In-house 7-223 (319) alignment
Range on Protein: 269-484
Range on HMM: 7-223/319.0
LQELVRNFESFHLednAKESIIGKEYKDIPMLLQD--MSIWPPDTYSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGYNGmEKAYICAQAPIYD
.||| .... ..    . |  . ||.|.. .  .|   |   ..  .||||.|...  .| |.||   ..    ||||.|||||.  ....| .|||. .
vqeLkerlkalas...tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe.rekfiatqaPlen

TIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEA-ERDVMLFIFQGWPDFGVPEQAGP
|| |||||.|| .. .||||... | .| |. ||||   ... | || ..|  . || |  | .  |.. ..|.|   |.|. | .. ||| .|||.|  
tiedfWrmvWeeessivvmltklveklkvklkkywp...eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

ILEFQEAVTINHTG---GPLLVHC
.|.. . .   . .   ||. |||
lldllkrirksrektqsgPivvhC

subfamily_PTPRB_pd Subfamily PTPRB 275-484 3.9e-47 155.7 In-house 11-225 (293) alignment
Range on Protein: 275-484
Range on HMM: 11-225/293.0
NFESFHLEDNA-KESIIGKEYKDIPMLLQDMSIWP---PDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPD
.||..  . .|  .  . .||...  . .|...     .   .||||.|..|  .. | |    ..  . |||||.|.||| ... .| .| |. .|. |
kfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvdd

FWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDTEYYGPFTVRNNYEEVLPFYKVVYLsvSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQ
||||.|| .....|||  ..|.|| || .|||  ..... .||  .|  . ||.|  . .  |  .|. ...||.|. . |. |||.||||.. ..|.| 
fWrmvwekkssiivmltqlvekgkvkCeeYWP..adeepvlyGdikvtlvaeeeledwvirel..kiekekeerkvrqyhftsWpdhgvPektktlldfv

EAVTIN----HTGGPLLVHC
..|  .    .. .|..|||
rtvreaiektaskrPivvhC

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 278-485 9.2e-26 85.1 In-house 11-177 (392) alignment
Range on Protein: 278-485
Range on HMM: 11-177/392.0
SFhLEDNAKESIIGKEYKDIP--MLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMI
.| .|.| . ... .|..|.|   . .. .   ..   ||||.|..| ... | |    ..  . |.|| .|....  |||||..|.|   .. |||||.
af.veknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmv

WECNVNTVVMLCGIFEGGknkcakywpppdtndteyygpftvrnnyeevlpfykvvylsvsinSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI
.. || |..|.  . ||                                                .  | |  | |  ||| .||...  .|.| . | .
fqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

NHTG--GPLLVHCR
..     ||..|| 
dfGqythpliihcs

subfamily_PTPN14_pd Subfamily PTPN14 280-472 5.4e-34 112.5 In-house 15-213 (300) alignment
Range on Protein: 280-472
Range on HMM: 15-213/300.0
HLEDNAKESIIGKEYKDIPMLLQDMSI---WPPDTYSKNRYRNVIPNKNTAVTLSGE-SIADRYINANFIDGY-NGMEKAYICAQAPIYDTIPDFWRMIW
.|| . .|. . .||  ||   .|  .     |.  .|||...|.| ... | ||      . ||||  |     | |. || ||.|.  |. |||.|.|
ilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvW

ECNVNTVVMLCGIFEGGKNKCAKYWPPP-DTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT
| .|. .|||  . |.||.|. ||.|   . ..|  .| | | ... |  . .    | .     . ||.|. . .. ||| ||||   . |.. | | 
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 281-485 2.2e-34 113.7 In-house 12-218 (315) alignment
Range on Protein: 281-485
Range on HMM: 12-218/315.0
LEDNAKESIIGKEYKDIP--MLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWEC
.. | . ... .|..|.|     .  .   .. ..||||.|..| ... | |    .|  . |||| .| ...  .||||..|.|   .. |||||... 
vnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqe

NVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEyYGPFTVRNNyeEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT
.| |.||.    || | ||..|||  ... .| .| . |     .. .    |   . .   |. | |  | |..||| ||..|.. .|..  .|  .. 
kvttivmvtkkqegdkikcrqywPdrkadsve.fGsikvell..sleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadng

--GGPLLVHCR
    .||||| 
kkefsllvhcs

0050432 (Phosphotyrosine protein) phosphatases II 282-485 1.6e-58 193.8 In-house 36-240 (308) alignment
Range on Protein: 282-485
Range on HMM: 36-240/308.0
EDNAKESIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLsgeSIADRYINANFIDGYN-GMEKAYICAQAPIYDTIPDFWRMIWECN
|.    ... .|.......  ...    . |.  .||||....|. .. | |   .  . ||||...|||. . ....|..|.| ..|. |||||.|| |
ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

VNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG
|...|||. ..| |..|||.|||.   .....||.|||..  ||||. |.| .| .. ..|. .| |. | . .|||.|||... ..|.| |.|   . |
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg

GPLLVHCR
|| .|||.
gpivVHCs

0047943 (Phosphotyrosine protein) phosphatases II 284-485 4.1e-55 182.5 In-house 8-213 (273) alignment
Range on Protein: 284-485
Range on HMM: 8-213/273.0
NAKESIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLsgESIADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNT
    ... .|..... |  ...      |.  .||||....|. .. | |  ..  . ||||...||||   | .|..|.| ..|. |||||.|| ||..
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrv

VVMLCGIFEGGKNKCAKYWPPPDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----T
.|||. ..| |..|||.|||.   . ...||.|||..  ||. . |.|  | .. .... .| |. | . ||||.|||..  ..||| |.|   .     
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

GGPLLVHCR
.|| .|||.
ngpvvVHCs

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 284-485 1.2e-33 110.9 In-house 14-217 (515) alignment
Range on Protein: 284-485
Range on HMM: 14-217/515.0
NAKESIIGKEYKDIP--MLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVN
| . ... .|..|.|   .  .        ..||||.|..| ... | |    ..    |.|| .| ...  .||||..|.|   .. ||||.... || 
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvt

TVVMLCGIFEGGKNKCAKYWPPPDtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDeaERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT--G
|..|.    || | ||.||||     |.  .| . |     |         | |  ..|   | |  | |..||| |||...  .| .  .|  .|    
tiamvtklkegdkikcgkyWPdkp.gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt

GPLLVHCR
 ||..|| 
hpliihcs

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 285-462 4.3e-06 20.4 In-house 23-201 (302) alignment
Range on Protein: 285-462
Range on HMM: 23-201/302.0
AKESIIGKEYKDIPMLLQDM---SIWPpDTYSKNRYRNVIPNKNTAVTLsgESIADRYINANFIDGYNgMEKAYICAQAPIYDTI---PDFWRMIWECNV
 ... . ||.| |  .  |.   ...  .  .||.  .|    .. | |  |  .| |.||  ..  . ...  | || |. |.     .||||... ..
ldtaevkkefkkidtmkvdlekCkafk.knlkknqsedvpildsnlvkl..eaepdsyvnaskvevPe.ltrsiilaQlpkvdsedsveeFWrmvfqeki

NTVVMLCGIFEGGKnKCAKYWPpPDTNDTEYYGPFTVRNNYEEVLPFYKvVYLSVSINSDEAERDVM--LFIFQGWPDFGVPEQAG
 .||.| |  |  |    ...|   ..| ..|| . | |   |     |   ... .  ..    |.  . ... |..  ||.. .
vsvvilvgeeelkk.tlselfp.kksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

0051299 (Phosphotyrosine protein) phosphatases II 288-485 3.5e-56 186.1 In-house 23-227 (288) alignment
Range on Protein: 288-485
Range on HMM: 23-227/288.0
SIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVV
... .|..... || |..      |  ..||||....|. .. | || ..    . ||||..|||||   | .|..|.|  .|. |||||.|| ||...|
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIv

MLCGIFEGGKNKCAKYWPPpdtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSIN----SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HT
||....| |..|||.|||.   .....||..||..  ||||. |.| .| |. .     |. .| |. | . .|||.|||. . ..|.| ..|     ..
mltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasg

GGPLLVHCR
||| .|||.
ggpvvVHCs

0036941 (Phosphotyrosine protein) phosphatases II 288-485 1.3e-53 177.6 In-house 13-215 (297) alignment
Range on Protein: 288-485
Range on HMM: 13-215/297.0
SIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLsgESIADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVML
... ||..... || ..|      |.. .||||....|. .| | |  ..  . ||||...||| . ....|..|.|  .|. |||||.|| ||...|||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

CGIFEGGKNKCAKYWPPPdTNDTEYYGPFTVRNNYEEV--LPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----TGG
.  .| |..|||.|||.  .... .||.|||..  .||  |. |.. .| |. . .. .| |. | . ||||.|||| . ..|.| |.|   .     ||
telvelgrekcaqywple.egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PLLVHCR
| ||||.
pvlVHCs

subfamily_CG42327_pd Subfamily CG42327 288-466 3.6e-34 112.9 In-house 5-185 (319) alignment
Range on Protein: 288-466
Range on HMM: 5-185/319.0
SIIGKEYKDIPMLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTLS--GESIADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLC
. . .|..|.| |.      |. .  |.|. ||.|  .| |.|   |.   | |..|... ||.  .  ||.||..  |.  ||||..|| .  ..| |.
edvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

GIFEGGKNKCAKYWPPPDTND-TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFqGWPDFGVPEQAGPILE
 ..| | ..||.|.|. .| | |. || . |     ||   | .  | .    .|  |..  . .  |.. .|| .  ... 
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaalia

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 288-484 2.9e-20 67.4 In-house 6-199 (267) alignment
Range on Protein: 288-484
Range on HMM: 6-199/267.0
SIIGKEYKDIPMLLQDMSI----WPPDTYSKNRYRNVIPNKNTAVTLSGESIAdrYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVM
  | ||.. |  . .. |     .. .   .||. ...| ..| | |. .     |||| ...||.  ..|.|  | |.  || ||. .| . .| ..|.
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee..yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivl

LCGIFEGgknKCAKYWPPpDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSdEAERDVMLFIFQGWPDFG-VPEQAGPILEFQEAVTINHTGGPLLV
|  .|..   .  ..|||    ... |  .||  . |.    |... | . ..  |. ..| |. .. |           |..       ..  . ||.|
ltkvftd...nirlfwPP.kmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

HC
.|
ac

0039614 (Phosphotyrosine protein) phosphatases II 289-485 1.1e-51 171.4 In-house 33-230 (297) alignment
Range on Protein: 289-485
Range on HMM: 33-230/297.0
IIGKEYKDIPMLLQDMSI-WPPDTYSKNRYRNVIPNKNTAVTLSGES---IADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVML
.. .|..... |  |.||   |   .||||....|. .. | |..|      . ||||...|||. . ...|..|.|  .|. |||||.|| .|...|||
llllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmL

CGIFEGGKnKCAKYWPPPDTndteYYGPFTVRNNYEEVLPFYKVVYLSVSInsDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----TGGPL
.  .| |. |||.|||.  .    .||.|||..  .|.|. |.| .|.|.   .. .| |. | . ||||.|||. .  .||| |.|   .     ||| 
tklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

LVHCR
|||| 
lVHCs

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 289-485 3.3e-47 156.1 In-house 23-224 (305) alignment
Range on Protein: 289-485
Range on HMM: 23-224/305.0
IIGKEYKDIPMLLQDMSIWPPD-TYSKNRYRNVIPNKNTAVTLSGESIAD--RYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLC
 . ..|| .... . . .   .   .|||...... ..  . |. ..  |   ||||...|||.. .|.|| ||.|. .|. ||||.|.|. |.|.|||.
gleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr.kkkyivaqgPlkntvadfWrliveekvstivmlt

GIFEGGKNKCAKYWPPPDTNDTEYyGPFTVRNNYEEVLPFYKVVYLSVSI-NSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGG---PLL
.. ||||.|| .|||   |...|. |.|.|  . |.  . |    |..|| ..|. .| |. . .  ||| |||..|. .|.. . |. ..  .   |||
klveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCR
||| 
VhCs

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 290-484 7.8e-43 141.5 In-house 7-208 (274) alignment
Range on Protein: 290-484
Range on HMM: 7-208/274.0
IGKEYKDIPMLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTLSGESIADR---YINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCG
. ||. ..|.  .   .  . . .||||....||.|. |.|. ||  |    |||||.| ||.. .|||. .| |.  |. ||||||.. .|. .|||  
lekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

IFEGGKNKCAKYWPPPD-TNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDeaERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT-----INHTGGPL
. |  ..|||.|.|    .. .| || . ....       |.|  |...  ..  ||.|. . .  |||  .|..| ..|.. . |       |.  .| 
lkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv

LVHC
.|||
vvhC

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 290-501 2.3e-24 80.9 In-house 21-230 (288) alignment
Range on Protein: 290-501
Range on HMM: 21-230/288.0
IGKEYKDIPMLLQDMSIWP-PDTYSKNRYRNVIPNKNTAVTLSgeSIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIF
. |||.| |   .  .|    .. ...||.|.     | | ||    .| ||.|| .   .  ..  ||||||.  ||  .|.|. | .|. .|||| . 
lkkeyrdspneasidiidsfianptrdryenlprcditrvkls..ddpdfyiaanvvssak.ykrrlicaqaPlngtieelWkmllesdveyivmlcell

EGGKNKCAKYWPPPDTNDTEYYGPFTV-RNNYeevLPFYKVVYLSVSINSDEAERDV-ML-FIFQGWPDFGVPEQAGPILEFQEAVtiNHTGGPLLVHCR
| ||.| |.|.|    . . .    || ....       |.| .|.  .| | |  | .    .. |.| ||||.  . | . | .  . .  |..||..
ekGkeksaeyfPsklGekarigrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhss

F--TRLLSLMFHMLLLKD
    |   |.. .. |. 
aGvGrtgtlililiales

subfamily_PTPRD_pd Subfamily PTPRD 291-484 7.8e-52 171.7 In-house 26-221 (564) alignment
Range on Protein: 291-484
Range on HMM: 26-221/564.0
GKEYKDIPMLlQDMSIW---PPDTYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLC
 .|||.| .  | ...     |   .|||| |...  .. | ||         ||||.|||||.  .|||| .|.|. .|| |||||.|| |..|.||| 
eeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmlt

GIFEGGKNKCAKYWPPPdtNdTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVH
 . | ||.||.||||    . || || .||  . || |  | .  .... ....  | |  | |  ||| ||||.| ..|.. . |.    .. ||..||
kleEkgkvkchkYWPek..g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVh

C
|
C

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 291-484 2.6e-14 47.6 In-house 22-216 (312) alignment
Range on Protein: 291-484
Range on HMM: 22-216/312.0
GKEYKDIPMLLQDMSIWPPDTY-SKNRYRNVIPNKNTAVTLSGESiaDRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFE
 |||| .  ...|        .   ||| |.        ||.|.   . || |||.      |. ..|.|.|. .|.  ||..       ....|||. |
tkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagde..nfyihanfvkictkper.fvctqgplentcthfwqlalslgstsiillcgfve

GGKNKCAKYWPPP----DTNDTEYYGPF----TVRNNYEEVLPfYKVvyLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHtgGPLL
 | .|||||        | .|   |  .     .  .  . .  ..|  | | ...   |  .  . .  ||| |.|.     | .  ||  ..   |..
dgsekcakyisdivgfvdledhrvyteycteieiggkskdkit.hrv..lkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk..kpvi

VHC
 ||
ahc

0046845 (Phosphotyrosine protein) phosphatases II 293-485 2.2e-56 186.7 In-house 5-212 (284) alignment
Range on Protein: 293-485
Range on HMM: 5-212/284.0
EYKDIPMLLQDM-----SIWPPDTYSKNRYRNVIPNKNTAVTLSGESIA---DRYINANFIDGYN----GMEKAYICAQAPIYDTIPDFWRMIWECNVNT
|.. ...|  ..         |  .|||||....|. .. | |. ..     . ||||...|||.      .|..|..|.|  .|. |||||.|| ||..
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VVMLCGIFEGGKNKCAKYWPPPdtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT---
.|||....| |..|||.|||.   ... .||.|||..  ||| . |.|  |... .. .. .| |. | . .|||.|||... ..||| ..|   ..   
IVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

-GGPLLVHCR
 ||| .|||.
gggpivVHCs

DSPc_SM00195 302-485 1.6e-47 157.4 In-house 27-203 (263) alignment
Range on Protein: 302-485
Range on HMM: 27-203/263.0
QdmsiwppdtySKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYW
.          |||||.|..|...| | |. |     . |||||.|.|.   .|.||..|.|  .|. |||||.|| .|...|||.  .| ||.||..||
k..........sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDtNDTEYYGPFTVRNNYEEVLP-FYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT--GGPLLVHCR
|    ...| .| ..| .  .|  .  ...  |... . .| .|.|  . ...||| |||... ..||. .||.  .    ||..||| 
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

PTPc_SM00194 302-485 1.6e-47 157.4 In-house 27-203 (263) alignment
Range on Protein: 302-485
Range on HMM: 27-203/263.0
QdmsiwppdtySKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYW
.          |||||.|..|...| | |. |     . |||||.|.|.   .|.||..|.|  .|. |||||.|| .|...|||.  .| ||.||..||
k..........sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDtNDTEYYGPFTVRNNYEEVLP-FYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT--GGPLLVHCR
|    ...| .| ..| .  .|  .  ...  |... . .| .|.|  . ...||| |||... ..||. .||.  .    ||..||| 
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 302-485 4.1e-27 89.6 In-house 46-224 (290) alignment
Range on Protein: 302-485
Range on HMM: 46-224/290.0
QDMSIWPPDT-YSKNRYRNVIPNKNTAVTLSGESIADrYINANFIDGYNGMekaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWP
 . .|.  .| . ||||..|. |  | | |.     | |. ||...| . |   .| .| .. ||. |.|||. . .| ..|||| ..| || ||..|.|
lerkifdkntefkknrykdvvcndktrvilkdGydGd.yvhanyvkGlkam...filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp

PPDtNDTEYYGPFTVRNNYEEVlPFYKVV--YLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEavTINHTGGPLLVHCR
  .  ..  .| .||    |.  .  ...   |||    .  |  .  .  . |||  |.  .  .|      .. .. ||. ||| 
eke.GevltfGeitvlcseedd.kdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlr..ilrkasGpvvvhcs

0045450 (Phosphotyrosine protein) phosphatases II 307-485 3e-51 170.4 In-house 51-242 (307) alignment
Range on Protein: 307-485
Range on HMM: 51-242/307.0
WPPDTYSKNRYRNVIPNKNTAVTLSGESIA---DRYINANFI--------DGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKC
  |   .||||....|. .| | || ..     . ||||...        |||.   ...|..|.|  .|. |||||.|| .|...|||.. .| |..||
llpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekc

AKYWPPPdtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI----NHTGGPLLVHCR
|.|||    ... .||.|||..  ||.|. |.| .| |. .  .. .| |. |.. ||||.|||.   ..|.| |.|      .  ||| ||||.
aqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

0043336 (Phosphotyrosine protein) phosphatases II 307-485 3.3e-51 169.8 In-house 41-218 (278) alignment
Range on Protein: 307-485
Range on HMM: 41-218/278.0
WPPDTYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdt
. |. ..||||....|. .. | || ..    . ||||...||||  .| .|..|.|  .|. |||||.|| .|.|.|||.. .| |..|||.|||    
llpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp....

NDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
.....||.|||..  ||.|. |.|  | |. . |  .| |. . . ||||.||||.  ..|.| .||     . .||.||||.
ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCs

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 307-456 9.4e-16 52.2 In-house 92-234 (244) alignment
Range on Protein: 307-456
Range on HMM: 92-234/244.0
WPPDTYSKNRYRNVIPNKNTAVTLSGESIADRYINANFIdGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGgknkcAKYWPppDTND
. |.   |||    .|     | ||  |... |||| |. |  |    || .| |. ||  |||.|. |  || .|.|  . |       .|||  |.. 
fnpnnswknregaglpfdfnrvplskgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp..dsep

TEYYG-PFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFG
 |.|    ||     . .   |   | .  . .|. . . .|    ||  |
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

0040438 (Phosphotyrosine protein) phosphatases II 309-485 1.1e-52 174.7 In-house 41-217 (317) alignment
Range on Protein: 309-485
Range on HMM: 41-217/317.0
PDTYSKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtND
|.  .||||....|. .. | || ..    . ||||...||.|   | .|..|.|  .|. |||||.|| .|...|||.  .| |..|||.|||    ..
penkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...ge

TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
| .||.|||..  ||.|. ...  | |. . |. .| |. | . ||||.|||.   ..|.| |||  .  . |||.|||| 
tltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCs

0037934 (Phosphotyrosine protein) phosphatases II 309-485 1.3e-46 154.5 In-house 8-186 (243) alignment
Range on Protein: 309-485
Range on HMM: 8-186/243.0
PDTYSKNRYRNVIPNKNTAVTLSGesiaDRYINANFIDGYNgmeKaYICAQAPIYDTIPD----FWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdt
|   |||||....|.... | |.|    . |||||.|....   . .|. |.|  .|. |    ||||.|| .....|||.  .| |..|||.|||    
penlsknrysdilpydhsrvkleg....sdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

nD-TeYYGPFTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT----------INHTGGPLLVHCR
 . . .||.|||..  ||.|. |.| .|...  . |. .| |. . . .|||.|||.   ..|.| ..|.           ...|||.||||.
.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 309-484 2.8e-45 149.6 In-house 45-219 (288) alignment
Range on Protein: 309-484
Range on HMM: 45-219/288.0
PDTYSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTND
.   .||||||..|   ..| | .  |     ||||..|||... .|.||..|.|. ||. |||....| ...|.||| .. ||||.|| .|||  |...
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP..dadk

TEYYGPFTVRNNYEEVLpfYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG--GPLLVHC
 . || .||    .. |   ..|  .. .. .. |...  . ...||| ||||.. |.||. . | ....   ||..|||
pknyGsvtvtlveskel..edfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC

subfamily_PTPN6_pd Subfamily PTPN6 309-484 3.8e-44 145.9 In-house 52-234 (306) alignment
Range on Protein: 309-484
Range on HMM: 52-234/306.0
PDTYSKNRYRNVIPNKNTAVTLSGESIAD-RYINANFID-GYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTND
|.  .||||.|..|  .| |.|. .|...  |||||.|.   .| .|.|| .|  . .|..|||||.|. | . .||.    | ||.|||.|||  |...
penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP..deee

TEYYGPFTVRNNYEEVLPFYKVVYLSVS-INSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--H----TGGPLLVHC
.| ||  .|.|  |. |  |..  |||| ..... ||.|. . |. ||| |||.. | .|.| | |. .  .    . ||..|||
keeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC

subfamily_PTPN12_pd Subfamily PTPN12 309-484 1.1e-42 141.0 In-house 38-214 (290) alignment
Range on Protein: 309-484
Range on HMM: 38-214/290.0
PDTYSKNRYRNVIPNKNTAVTLSGESIAD--RYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdTND
. .. ||||....|  .. |.|| ..  .   ||||||| | .| ...|| ||.|. .|. ||||||||.||. |||.| ..| ||.||..|||   ...
eenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee.gee

TEYYGPFTVRNNYEEVLP-FYKVVYLSVSINsdEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHC
.  .|.|.| .. |. .   . .  | |  .  ...| |  | .. ||| |||..| ..||. |.|     .   ||.|||
elefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC

subfamily_PTPRG_pd Subfamily PTPRG 309-485 2.5e-42 139.8 In-house 45-228 (563) alignment
Range on Protein: 309-485
Range on HMM: 45-228/563.0
PDTYSKNRYRNVIPNKNTAVTLSGESIADR---YINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtN
|.   |||| |...  .. |.||. .  ..   |||||.||||.  .||.| .| |. ||. |||||||| ||...||.  . | |..||  |||    .
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...d

DTEYYGPFTVRNNYEEVLPFYKVVYLSVSI-----NSD-EAERDVMLFIFQGWPDFGVPEQAGPILEF--QEAVTINHTGGPLLVHCR
..| || ..|.   ||||  | |  |..       ... . |. |. . .  ||| ||||.. | | |  ... . ... ||..|||.
esetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcs

subfamily_PTPN3_pd Subfamily PTPN3 309-484 1.4e-38 127.4 In-house 39-215 (280) alignment
Range on Protein: 309-484
Range on HMM: 39-215/280.0
PDTYSKNRYRNVIPNKNTAVTLSGESIadRYINANFIDG-YNG--MEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdTN
|.  ||||||...|  .| |.|. ..    |||||...   ..  . . || .| |. .|  |||.|.|| .....|||  . | |. || .|||   |.
penlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe..te

DTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH--TGGPLLVHC
|.  || |.|. . |.    | .  | .. .. . || .. . .  ||| |||...  .||| | |   .  .  |..|||
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 309-479 6.6e-30 99.0 In-house 31-201 (297) alignment
Range on Protein: 309-479
Range on HMM: 31-201/297.0
PDTYSKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNG-MEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNdT
. .  |||||...  ..| | | .      ||||...   .   .  ||.|| |. .|. |||....| .|...||.. . |.|..||| |||  . .  
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe.r

EYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGGP
   | . |    .    | .|.   . .   . .| |    | .||| ||| .   .  ||  |.      |
lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavp

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 309-485 2.7e-29 97.3 In-house 46-229 (325) alignment
Range on Protein: 309-485
Range on HMM: 46-229/325.0
PDTYSKNRYRNVIPNKNTAVTLS--GESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMI--WECnvnTVVMLCGIFEGGKNKCAKYWPPpDT
|.  .|||..||.. ... | |   ...    ||||...  . .  . .. ||||  .|| |.||..  |.|   .||..  ....||..||.|||  . 
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWrc...svvvvlneldlgkdrcavywpk.em

NDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEF-------QEAVTI-NHTGGPLLVHCR
 ..  .|.. |.    | .  |    | |   ..   | |  | .|.|.|.||...   .. .       .| ||   .. .|.|||| 
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

0045098 (Phosphotyrosine protein) phosphatases II 310-485 7.9e-50 165.2 In-house 32-214 (278) alignment
Range on Protein: 310-485
Range on HMM: 32-214/278.0
DTYSKNRYRNVIPNKNTAVTlsgesiaDrYINANFIDGYngmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtNDTEY
. ..||||....|. .. |        | ||||..||||    |..|..|.|  .|. |||||.|| .....|||.. .|.|..|||.|||.   .....
gnldknRykdilpydhsrVk.......d.YINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggslt

YGPFTVRNNYEEVLPFYKVVYLSVSIN----SDEAERDVMLFIFQGWPDFGVPEQA--GPILEFQEAVTIN---------------HTGGPLLVHCR
||.|||..  ||||. | .. | |       .|  .| |  . . .|||.|||..    ..||. | .                    ||| ||||.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCs

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 310-484 1.9e-41 137.1 In-house 40-215 (281) alignment
Range on Protein: 310-484
Range on HMM: 40-215/281.0
DTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDT
.   ||||.|..   .| |..  . |.    ||||||..||.| ||.|| .|.|. ... .||.|.|| .|...||.    |.|| || .|||  | | .
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP..ddnse

EYYGPFTVRNNYEEVLPFYKVVYLSVsINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAV---TINHTGGPLLVHC
  || .||... ||  . |    ...  ...  .|.|  . .. ||| |||...  .|||...|   | ..|  ||..||
lkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 310-484 2.8e-40 133.4 In-house 55-230 (298) alignment
Range on Protein: 310-484
Range on HMM: 55-230/298.0
DTYSKNRYRNVIPNKNTAVTLSG---ESIADrYINANFIDGYNGMEkAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTND
.  .|||| ..|.   . | |.    . ..| |||| |...|.| . |.| .|||.  |. |||||..| ...|.|||  . | .| |. ||||   .. 
enkkkNRyadiialdssRvvLekedadeesd.YiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP...deg

TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH-TGG--PLLVHC
.| || .||.   .|.   . |. | || .. | || |  . |  ||| ||||.|  .|.. . |  ..   |  |..|.|
ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqC

subfamily_PTPRN_pd Subfamily PTPRN 310-485 3.8e-28 93.0 In-house 55-232 (297) alignment
Range on Protein: 310-485
Range on HMM: 55-232/297.0
DTYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDtNDT
.. .|||...|.|  .. |.|. |. |  . |||| .|   .  . ||| .|.|. .|. |||.|.||  |  .|.|. . | | ..|..|||  | . .
knvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp..d.eGs

EYYGPFTVRNNYEEVLP-FYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG--GPLLVHCR
| |. . |.   | .    | |  . .     .  | |  | |  ||. ||| .| ..|||.  |   . |   |..||| 
evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcs

0040439 (Phosphotyrosine protein) phosphatases II 311-485 8.1e-48 158.5 In-house 11-187 (249) alignment
Range on Protein: 311-485
Range on HMM: 11-187/249.0
TYSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtNDTE
  .||||....|. .. | ||   .   . ||||..||||.   . .|..|.|  .|..|||||.|| .....|||.  .| |..|||.|||.   ... 
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsl

YYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----TGGPLLVHCR
.|| |||..  .||.. |.| .| .. . |  .| |. . . .|||.|||.   ..|.| |||   .    .|||.|||| 
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 311-484 2.8e-44 146.5 In-house 46-220 (318) alignment
Range on Protein: 311-484
Range on HMM: 46-220/318.0
TYSKNRYRNVIPNKNTAVTLSGE--SIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTE
   |||| |...  .| | |.    .    |||||.||||.  .|||| ||||. .||.|||||.|| |  ..|||  . | ||.|...|||    ....
nkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP...skgsr

YYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN---HTGGPLLVHC
 ||  .|  . |  |  | .  ..|. .  |..|.|  . .  ||| ||||... .|..   |.     .. ||..|||
sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

subfamily_PTPN9_pd Subfamily PTPN9 311-472 1.6e-41 137.2 In-house 42-203 (297) alignment
Range on Protein: 311-472
Range on HMM: 42-203/297.0
TYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTE
  .|||| .|.   .| |.|. ..      ||||||.|||.  .||.| .| |.  |. |||||.|| .| ..||   . | |. ||..|||. ......
nleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl.eeessa

YYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT
 .| ..|.|   |.   |||  | ..   .| .| |. | | .|||.|||..|  .|.. |.| 
efgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 311-484 1.3e-39 130.9 In-house 9-182 (250) alignment
Range on Protein: 311-484
Range on HMM: 9-182/250.0
TYSKNRYRNVIPNKNTAVTLSGES---IADrYINANFIDGYNGMeKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNkCAKYWPppdTNDT
   |||| ..|. ... | |  |.   ..| |||| |..||..  ||.| .|.|. .|| |||||..| ...|.|||  . | .|. . .|||   .. .
nkeknryadiialdssrvvLekekgdkesd.yinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP...veka

EYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG---GPLLVHC
| ||  ||    .|.   |..  | .| .. . || |  . |  ||| ||||.|  .||... |  ..     .|..|.|
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC

subfamily_PTPN13_pd Subfamily PTPN13 311-484 1.2e-37 124.7 In-house 37-209 (273) alignment
Range on Protein: 311-484
Range on HMM: 37-209/273.0
TYSKNRYRNVIPNKNTAVTLSGESIadrYINANFIDGYNGMEK-AYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEY
  .|||||||.|  .| |.|..|.    ||||..|    | ..  || .| |. .|. |||.|.|| ... ..|.    |.|| || .|||    . .  
nkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

YGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT-GGPLLVHC
.. ..|..   . |  ..|  | |. .  .. |.|. . |  ||| ||| .| ..|.|   |   .|  ||..|||
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhc

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 311-488 2.4e-35 116.8 In-house 46-227 (290) alignment
Range on Protein: 311-488
Range on HMM: 46-227/290.0
TYSKNRYRNVIPNKNTAVTLSGE----SIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTnD
   .||..|.... .  .||         .. |||| .|.||.  .|.|| .|.|. .|. |||..||. .|  .|||. | | ||.|| .|||  |. |
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp..ds.d

TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSD-EAERDVMLFIFQGWPDFG-VPEQAGPILEFQEAVTI--NHTGGPLLVHCRFTR
|. ||.|... . ||.|  |    |.|  ..  .|.. |. . .. |.. | |..... .| ..| . .   .. ....|||  | 
tkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtv

subfamily_PTPRK_pd Subfamily PTPRK 311-485 4.6e-35 115.9 In-house 43-218 (314) alignment
Range on Protein: 311-485
Range on HMM: 43-218/314.0
TYSKNRYRNVIPNKNTAVTLS---GESiADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdtNDT
  .|||. ....  .. |.|    |..    ||||..||.|.   .|.| .| |. .|. ||||.... |  ..|||  . | |. || ||||    .||
nreknrsgdilaydrsrvflitidgdp.ssdyinaalidsykr.paafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP....edt

EYYGPFTVRNNYEEVLPFYKVVYLSVSI--NSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
| ||.. |     |.|  . |  ..|.    . |. | |  | | ||||..|| .|  .|..   |     .. |...||| 
evygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCs

subfamily_PTPN1_pd Subfamily PTPN1 311-485 6e-35 115.3 In-house 32-209 (290) alignment
Range on Protein: 311-485
Range on HMM: 32-209/290.0
TYSKNRYRNVIPNKNTAVTLSGESIadRYINANFIDgYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYY
  ..||||.| | . . ..|  ..   .||||....  . ... || .| |. .|.  ||.|.|| .  .||||  . | ...|||.|||  . ...  .
nrnlnryrdvspydhsrikleradn..dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

G--PFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQ----EAVTINHTGGPLLVHCR
    ..|.   ||.  .|.|  | .   . .  |... | .  ||||||||  .  |.|     |. ....  || ..|| 
edtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 311-485 8.9e-31 101.8 In-house 33-207 (283) alignment
Range on Protein: 311-485
Range on HMM: 33-207/283.0
TYSKNRYRNVIPNKNTAVTLSGESIadRYINANFID--GYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTE
   |||.....|  .  | |  ||    |||| ||     .  .| || ||.|. .|. |||.|... .. ..|||  . |. . ||..|||    . .|
nkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP...krGse

YYGPFTVRNNYEEVLPFYKVVYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI--NHTGGPLLVHCR
 ||.|||  . |     . .  | .  | | ...  .  . ...| ..|       .. |   ..   ..  ||..||| 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCs

0049772 (Phosphotyrosine protein) phosphatases II 311-485 4.1e-23 78.0 In-house 46-220 (314) alignment
Range on Protein: 311-485
Range on HMM: 46-220/314.0
TYSKNRYRNVIPNKnTAVTLSGESIAD-RYINANFIDGYngmeKAYICAQAPIYDTIPDF----------WRMI--WECNVNTVVM--------------
  .|||| ...|   . | |.|... .  ||||...||.    ...|..|.|   |. ||          |||.  .. || ..||              
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCGIFEGGknkcakywpppdtndteyygP----------FtvrnnyeevlpfykvvylSVSINSDEAERDVMLFIFQGWPDFGVPeQAGPILE
       |... ..|                    .                             ..  . .  || .. ..   .||...|     ..|
aAlgKtpllildgng....................neptaadlellk..................eelydpelferlgikylripvpDgsap.lledfde

FQEAVTINHTGGPLLVHCR
| |..  ...|||.||||.
flefieeadkggpvlvHCk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 311-485 3.2e-21 70.2 In-house 37-208 (281) alignment
Range on Protein: 311-485
Range on HMM: 37-208/281.0
TYSKNRYRNVIPNKNTAVTLSG---ESIADRYINANFIDGyNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDT
   |||| |.     . | |     .  .  || ||.|     ... || .| |  .|  |||||||. |  ..|||| . |  ..|||.|.|  ..   
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr.nahcc

EYYGPFTVrnNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTggPLLVHCR
  .  ..|  .||.      .|   . .  .   | .  .... |||. ||| .  .|.    .    |  | ..|| 
lqfdklsv..syedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst..ppvihcs

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 311-406 2.1e-15 51.3 In-house 47-157 (350) alignment
Range on Protein: 311-406
Range on HMM: 47-157/350.0
TYSKNRYRNVIPNKNTAVTLS-----------GESIADrYINANFIDGY---NGMEKA--YICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNK
...||||.|..|   . | |              |  | |||||..        ..    || .|||.  |. ||...| . .|. ...|   .| . .|
lfaknrYknilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPPPDTND
| .||.  . .|
cyrYWqegsydd

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 311-359 3.8e-07 24.2 In-house 48-94 (95) alignment
Range on Protein: 311-359
Range on HMM: 48-94/95.0
TYSKNRYRNVIPNKNTAVTLSGESIADrYINANFIDGYNgMEKAYICAQ
   |||. |..|   | |.|.    .| |||| |.|||    ..||.||
nipknrflnifpydatrvvlttkrdsd.yinacfvdgya.rkncyiaaq

0042113 (Phosphotyrosine protein) phosphatases II 312-485 9e-48 158.2 In-house 10-184 (245) alignment
Range on Protein: 312-485
Range on HMM: 10-184/245.0
YSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtNDTEY
 .||||....|. .| | || ..    . ||||...|||.  .| .|..|.|  .|..|||||.|| ...|.|||.  .| |..|||.|||.   ... .
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...geslt

YGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI---NHTGGPLLVHCR
|| |||..  ||.|. |.| .|.|. . |  .| |. . . .|||.|||.    .|.| |.|     .. .||.||||.
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

subfamily_Ptp69D_pd Subfamily Ptp69D 312-486 2.2e-42 140.3 In-house 49-228 (307) alignment
Range on Protein: 312-486
Range on HMM: 49-228/307.0
YSKNRYRNVIPNKNTAVTLSGESIAD--RYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdtnDTEY
  |||| ....  .| | |.     .   ||||.|| ||.  .| .|.||.|.  || ||||||.| .|...|||  . |  ..|||||||     |.  
alknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devq

YGPFTVRNNYEEVLPFYKVVYLSVSINSD-----EAERDVMLFIFQGWPDFGVPEQAGPILEFQEAV--TINHTGGPLLVHCRF
||   |.   ||  . |    |.|| . .     |..| |. . ..||.|. |||.|  .|.. | |    ..  .|..|||. 
ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsa

subfamily_PTPRA_pd Subfamily PTPRA 312-484 4.4e-39 129.3 In-house 59-235 (330) alignment
Range on Protein: 312-484
Range on HMM: 59-235/330.0
YSKNRYRNVIPNKNTAVTLS---GESIADrYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTE
  |||. |..|.. . | ||   |.  .| |||| |||||.  .| .| || |  .|. |||||||| .  |.|||  . |  ..|||.|||   .. . 
keknrvvnilPydfsrvilsvkeGveesd.yinasfidGykekdk.fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP...deGlv

YYGPFTVRNNYEEVLPFYKVVYLSVS----INSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI--NHTGGPLLVHC
 ||  .|  . |.||  | |  . |        ....| |  | |..|||.||| ..  .|.. ..|    . ..||. |||
tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 312-485 5.4e-36 119.0 In-house 4-180 (237) alignment
Range on Protein: 312-485
Range on HMM: 4-180/237.0
YSKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDTEYYG
  |||| |..    . | | |   .  ||||....|..|  | ||.|| |.  .  |||.|.|. .   .||| |. || . || ||||  .|.. . ||
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp..stdqpaayg

PFTVRNNYEEVLPFYKVVYLSVSINSDEAE-RDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI--NH--TGGPLLVHCR
 .||    .| .  | |  | .| .    | | .  . |  ||| |||.|.  .| |.  .    .|    || ..|| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcs

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 312-484 4.5e-33 109.9 In-house 62-231 (319) alignment
Range on Protein: 312-484
Range on HMM: 62-231/319.0
YSKNRYRNVIPNKNTAVTL---SGESIADrYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifeggKNKCAKYWPppdTNDTE
  |||. |...  .. | |    ||  .| |||| |..||   .| || || |  .|. |||||||| |. |.|.|       |.||..|||    .  .
kdknriinilafdknvvklerliGeefsd.yinasfvtGyqrkdk.yiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp...lkivi

YYGPFTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI----NHTGGPLLVHC
 .. | |. .  |    | |  . .| ..  .  |..  | |.|||| |||... ... . . |.     ..   ...|||
keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 312-490 2.7e-31 103.4 In-house 39-223 (287) alignment
Range on Protein: 312-490
Range on HMM: 39-223/287.0
YSKNRYRNVIPNKNTAVTLSGES-IADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdtNDTEYY
 .|||| .|.|  .| | || |.     |||||.. .|.  ..|.|.||.||  |. ||||...| .. .|...    | ...|| |||| .  .     
vkknryadvlPiddtrvllsaegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrv

GPFT-VRNNYEEVLPFYKVVYLSVsINSDEAE-RDVMLFIFQGWPDFGVPEQAGPILEFQEAV-------TINHTGGPLLVHCRFTRLL
| .. |  .|.   | | |  | . |. .  | | |  . .  ||| ...  |  .. |   |             |||.||.     .
GGysvvlldydikePeygvralrl.idletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 312-485 1.4e-27 91.6 In-house 52-225 (297) alignment
Range on Protein: 312-485
Range on HMM: 52-225/297.0
YSKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYNGmekAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKnKCAKYWPppDTNDTEy
..|.||.|..| .   |.|          |.|| |. |..     .|. | |  .|. |||.|... .|.|.|||    |. | |||.||.  |.  |. 
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvtt.

YGPFTVRNN-YEEVLPFYKvVYLSVSINSDEAERDVMLFIFQGWPDFGVPE--QAGPILEFQEAVTINHTG---GPLLVHCR
.|  .|  .  .|   | |   |.|. ..  |.| |  . |  |||  |..  .|  .|.. . |  .. .   ||||||| 
fGdvsvvllsvsereGfik.relevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl

subfamily_ptpA1_pd Subfamily ptpA1 312-472 5.8e-25 82.9 In-house 48-216 (418) alignment
Range on Protein: 312-472
Range on HMM: 48-216/418.0
YSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGynGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPD------
 ||||| |..| . | | |    .     |||||.|||     | .||.| |. .|| |||||.||  .  .|||    |  . || .|||         
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

--TNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT
   |  | .| ..|        |  ...   . .  .   ||.  . ..||||. .|... |. ..  ..|
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 312-485 6.2e-25 82.5 In-house 56-229 (305) alignment
Range on Protein: 312-485
Range on HMM: 56-229/305.0
YSKNRYRNVIPNKNTAVTLSGESiADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYYG
 .||||..|  . ..|| |.  |    || ||..      || .|||| |. .|| .|| |. . .|. .||||   | || |||.|||    .  |  .
itknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

PFTVRNNY----EEVLPFYKVVYLSVSINSDEaERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTinHTGGPLLVHCR
   | |       |  .  ..  | .. . |. .  |  . .  ||| |||      ||.  |.    .  |..||| 
givvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslellsair..gskvpivvhcs

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 312-485 1.5e-24 81.1 In-house 53-231 (310) alignment
Range on Protein: 312-485
Range on HMM: 53-231/310.0
YSKNRYRNVIPNKNTAVTLSG-ESIADRYINANFIDGyNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDTEYY
  |||| .|.   .. | |    |  . || ||..   | . ...||.| |.  || ||||||..   .....|| . | |. ||  |||      || |
mhknrysdvvcldtsrvklkidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp..slgvtety

GPFTVRNNYEEvLPFYKVVYLSVSINSD-----EA-----ERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHtgGPLLVHCR
|   | |  |     .... |.|..  |     |      |  | |  .  ||| |||..    .  .    . |  || .||| 
gcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcs

subfamily_CG7180_pd Subfamily CG7180 312-471 2.6e-23 77.1 In-house 43-210 (296) alignment
Range on Protein: 312-471
Range on HMM: 43-210/296.0
YSKNRYRNVIPNKNTAVT---LSGESIADrYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKnKCAKYWPPPDtndTE
  |||. .|.|  .. |    | ||.  | |||| ..|..   .|.||  .||  .|. .|||.... ....||.|.  |.  | .. .|||.      |
reknrdvkvvPyDynRvvLekldGeeksd.Yinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...ke

YYGPFTVRNNYEEVLPFYKVVYLSVSIN----------SDEAERDVMLFIFQGWPD-FGVPEQAGPILEFQEAV
 ||.. |    |. ..  |   . .  .           .  .| |.|| .. |.    ||  .  ..|. . |
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 312-485 5.8e-22 72.8 In-house 49-227 (305) alignment
Range on Protein: 312-485
Range on HMM: 49-227/305.0
YSKNRYRNVIPNKNTAVTLSGeSIADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYY-
  ||||..|    |  | | | .    || ||..       | .||.|||. .|  ||| | .. .|... ||| . | | .||..|..  | .  |.  
agknrykdvgcldnnrvkleg.pwpheyihanyvstp.tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

--GPFTVRNNYEEVLPFYKV-----VYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTinHTGGPLLVHCR
     .|. .  . | | |          . |. . |  | |  . .  ||| |||     |||. |      . ||. ||| 
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar..pskgpivvhcs

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 312-393 1.4e-09 31.9 In-house 38-122 (347) alignment
Range on Protein: 312-393
Range on HMM: 38-122/347.0
YSKNRYRNVIPNKNTAVTLSGESI-------ADRYINANFIDgYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMlcgIFEGGKN
 |||| ..|  . .| | || |         .. ||||  |  ..  .| || .| |. ||. |||.|.   .|  ||    |||  |.
lsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt...ifepikd

Y_phosphatase Protein-tyrosine phosphatase 313-485 3.6e-47 156.1 Pfam-A 3-178 (235) alignment
Range on Protein: 313-485
Range on HMM: 3-178/235.0
SKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGP
.||||....|  .| | |.|.. .  |||||...||.  .|..|..|.|. .|| |||||.|. .|...|||.   | |..|||.|||  .......|| 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.eeeeesltygd

FTVRNN-YEE-VLPFYKVVYLSVSINSDE-AERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH--TGGPLLVHCR
..|..   |.     | .  |... . .| ..| |. . ...||| ||||.. ..|.. ..|  ..  . ||..||| 
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

Y_phosphatase Protein-tyrosine phosphatase 313-485 3.6e-47 156.1 In-house 3-178 (235) alignment
Range on Protein: 313-485
Range on HMM: 3-178/235.0
SKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGP
.||||....|  .| | |.|.. .  |||||...||.  .|..|..|.|. .|| |||||.|. .|...|||.   | |..|||.|||  .......|| 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.eeeeesltygd

FTVRNN-YEE-VLPFYKVVYLSVSINSDE-AERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH--TGGPLLVHCR
..|..   |.     | .  |... . .| ..| |. . ...||| ||||.. ..|.. ..|  ..  . ||..||| 
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 313-484 2.7e-41 136.4 In-house 22-204 (270) alignment
Range on Protein: 313-484
Range on HMM: 22-204/270.0
SKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTND-TEY
  |||....|. .| |.|. ..   |  |||||.. |..| .|.||.|..|   |. .||||||| .|...||. |. | |..||..|||.   .  .  
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

YGPFTVRNNYEEVLPFYKVVYLSVSiNSDEaERDVMLFIFQGWPDFGVPEQAG------PILEFQEAV---TINH-TGGPLLVHC
.|  .|..  ||   .| .  | .  .. | || .. | .. ||| |||....       .|.  .||   . ..  ..||||||
dgkikvlalseekeegyiltrlrle.ekge.errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 313-485 7.1e-40 131.9 In-house 51-220 (315) alignment
Range on Protein: 313-485
Range on HMM: 51-220/315.0
SKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTndTEYY
 |||| |.|.  .. | |          |.|||||||||  .. ||.||.|   .. ||||...| .. ..||| .. || |.|. ||||  |      |
qknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dk..kviy

GPFTVRNNYEEVLPFYKVVYLsvSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG--GPLLVHCR
|..||    |||   | |  |  |. ...  |.|. . .  ||| |||. . |....   |   ||   |...|||.
Gkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcs

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 313-489 5.9e-36 118.9 In-house 49-223 (287) alignment
Range on Protein: 313-489
Range on HMM: 49-223/287.0
SKNRYRNVIPNKNTAVTLSGESiaDRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTEYYGP
 |||......  |  | | ||   . |||| |||||.  .||.| |..|. .|. .||..|.. ||...||||   |  ...| .|||   .... ..|.
dknRltqilvpdnyrvllkgeh..pdyinavfidgyke.kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp...eeksvvlGe

FTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFG-VPEQAGPILEFQEAVTI--NHTGGPLLVHCRFTRL
....   |||   | .  | |  .. ..... |. . .  |.. | |.|..  .| ..| .     .. ....|||  |  
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvG

subfamily_PTPN23_pd Subfamily PTPN23 313-484 2.4e-35 116.7 In-house 45-219 (288) alignment
Range on Protein: 313-484
Range on HMM: 45-219/288.0
SKNRYRNVIPNKNTAVTLSgeSIADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGP
.|||.|...|  .. |.|   .  | |||| |. .   .   .|..|||.  |. |||.|..|  ....|||    | ||.|...|||  |...|. .|.
eknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP.edkgetvkfgd

FTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI------NHTGGPLLVHC
..|  . .. .. .    |...... .| ..|..  .. ||..|||.  . .|.| ..|        ...  ||.|||
lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 313-484 9e-33 109.0 In-house 27-195 (284) alignment
Range on Protein: 313-484
Range on HMM: 27-195/284.0
SKNRYRNVIPNKNTAVTL---SGESIADrYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifeggKNKCAKYWPppdTNDTEY
 |||. ....  .. | |    ||  .| |||| || ||   .| || .| |  .|. |||||||| |. |.|.|       |.||..|||    .  . 
dknrighilafdknvvklerliGeefsd.yinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstivllt......kdkcsqywp...lkivik

YGPFTVRNNYEEVLPFYKVVYLSVSINSD-EAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI----NHTGGPLLVHC
.. | |. .  |    | |  . .| ..  .  |..  | |.|||| |||... ... . . |.     ..   ...|||
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 313-485 6.8e-31 102.2 In-house 50-220 (439) alignment
Range on Protein: 313-485
Range on HMM: 50-220/439.0
SKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKnkcakYWPppdTNDTEYY
.||||..| .   | |||          |||||.|.||   .| || .|.|  .|  ||||...| .. |.|||. ..|  |     |||   ...  .|
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyd.dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywp...sdaevcy

GPFTVRNNYEEVLPFYKVVYLSVSINSD--EAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI---NHTGGPLLVHCR
|  .|| . .  || | .  . |  . |  | || |. | .  |||  || ||  .|.|  |.     ..  ||..||| 
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcs

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 313-485 3e-28 93.6 In-house 10-182 (239) alignment
Range on Protein: 313-485
Range on HMM: 10-182/239.0
SKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdtNDTEYY
.|||| |..    . | |   |      ||||...  |.|  ||||..|  .  .  |||||.|.     .||| |. || |.|| .|||    . |  |
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp....dstsky

GPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGG--PLLVHCR
  . |     ||.  | .  . .|   .  || |  . |  ||| |||. |  .| ..  .| .   |  | ..|| 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 313-485 3e-28 93.6 In-house 9-181 (239) alignment
Range on Protein: 313-485
Range on HMM: 9-181/239.0
SKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdtNDTEYY
.|||| |..    . | |   |      ||||...  |.|  ||||..|  .  .  |||||.|.     .||| |. || |.|| .|||    . |  |
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp....dstsky

GPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGG--PLLVHCR
  . |     ||.  | .  . .|   .  || |  . |  ||| |||. |  .| ..  .| .   |  | ..|| 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

0041856 (Phosphotyrosine protein) phosphatases II 313-485 1.8e-27 91.5 In-house 3-117 (182) alignment
Range on Protein: 313-485
Range on HMM: 3-117/182.0
SKNRYRNVIPNKNTAvtlsgesiADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifeggknkCAKYWPppdtndteyygp
.||||....|. ..            |||||...|.    . .|..|.| ..|..||.||..| ...|.|.|.         .  |||            
dknrysdilpydhsr........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp............

ftvrnnyeevlpfykvvylsvsinsDEAERDVMLFIFQGWPDFGVPEqAGPILEFQEAVTInhTGGPLLVHCR
                         .. || .. ... .|||.|||.    .|.| |.|     ||| ||||.
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCs

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 313-484 1.1e-24 82.0 In-house 43-216 (307) alignment
Range on Protein: 313-484
Range on HMM: 43-216/307.0
SKNRYRNVIPNKNTAVTLSGESIADRYINANFIdGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYYG-
 ||||..|   ... . .  . .|  || ||.. |     | .|||| |  .|. .|| |. . .|..|.||| . | .| || .|||  . .   .   
dknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgea

PF--TVRNN-YEEVLPFYKVVYL-SVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHtgGPLLVHC
|   .| |   ... |  ... . .. ..  .  | .  . .. ||| |||.     ... |||  ..   |..|||
pntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt..npvvvhc

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 313-485 1.2e-19 65.2 In-house 52-222 (301) alignment
Range on Protein: 313-485
Range on HMM: 52-222/301.0
SKNRYRNVIPNKNTAVTLSGESiADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEyYGP
 |.|| .|  . .||| .  .      | ||.|.   |  . .|..|.|. .|  ||| |.   .|...|||.   |  ..||..| |   ... .  | 
dkhryptvPckPstavevivdG.krvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld.igr

FTVRNNYEEVLPFYKVVYLSVSIN--S-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVtiNHTGGPLLVHCR
|... . .|..   |..  .. ..  . . | | |. . .. |.| |||.    . .. | |   ..  |..||| 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelv..kksekPivvhcs

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 313-386 8e-08 26.2 In-house 49-116 (303) alignment
Range on Protein: 313-386
Range on HMM: 49-116/303.0
SKNRYRNVIPNKNTAVTLSGESiadrYINANFIDgYNGMEKAyICAQAPIYDTIPDFWRMIWECNVNTVVMLCG
 |||. .||    . | ||  |    || |....  .   || | .| |.  |  |||.|| | .|. |..|  
dknrfvdvicldhskvklsdss....yihasyle.ldsskka.iltqlplshtaadfwqmiieqkvkcvllllt

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 314-485 2.1e-28 93.9 In-house 43-234 (301) alignment
Range on Protein: 314-485
Range on HMM: 43-234/301.0
KNRYRNVIPNKNTAVTLSGE----SIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDtNDTEY
 ||..|. . ..  ..|. .    .   .||||..||||.  .|..| ||.|.  |. ||||.||.  . ..||...  || |.|| .|||  . ...|.
lnrfknitvyddnriilkpkpnldlcqreyinasyidgyse.kkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse.aesee

YGPFTVRNNYEEVLPFYKVVYLSVSI---------------NSDEAERDVMLFIFQGWPDFGV-PEQAGPILEFQEAVTI--NHTGGPLLVHCR
.|||||  . | |.| . .  |.| |               .|| . .||. .    ||. || .|..  .   .. .       |||..||| 
fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCS

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 314-485 3.8e-20 67.0 In-house 38-211 (285) alignment
Range on Protein: 314-485
Range on HMM: 38-211/285.0
KNRYRNVIPNKNTAVTLSGEsiADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdTNDTEYYGPF
 ||| .|   ..| | |        || |...      . .|| .| |. .|. |||.||.. ..  |.||| .|||| .||| |.|     .   .| .
lnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek.lgevvkfgky

--TVRNNYEEVLPFYKVVYLSVsINSDEAERDV-MLFI--FQGWPDFGVPEQAGPILEFQEAV-TINHTGGPLLVHCR
  |. .  || .    .  |.| ||...|  .   .       |||   ||.| |..|. . |  .|    |. ||| 
eitlteckeeaiagtilnaltv.intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcs

subfamily_eak_pd Subfamily eak 318-489 5.3e-13 43.1 In-house 58-223 (332) alignment
Range on Protein: 318-489
Range on HMM: 58-223/332.0
RNVIPNKNTAVTLSGE-SIADRYINANFIDgYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGPFTVR
 ...|..   | |.      . ||||  .. .. . . || . ..  | .. ||.|. | .  ..|.|    | . .|  ||.|  .| .   .| . | 
vkivpydrylvrltssqlnrlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp.dktreelkfGildve

N-NYeEVLPFYKVVYLSVSinSDEAERDVMLFIFQGWPDFGVPEQAgPILEFQEavTINHTGGPLLVHCRFTRL
  ..      ...  | .|    .    |. . . || .. .|      | ...  .. ..| .||.  . . |
rkef.vkrniletrllels..kGnethrvlhykvfGwtettlpkye.dflalrk..vmkevGvlllivmksall

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 320-395 1.6e-07 25.1 In-house 43-118 (332) alignment
Range on Protein: 320-395
Range on HMM: 43-118/332.0
VIPNKNTAVTLSGESIADRYINANFIDGYNgMEKAYICAQAPIYDTI-PDFWRMIWECNVNTVVMLCGIFEGGKNKC
.     . | |. .   | . ||...|||.  . ||| ||||. |     ||||. | . . ....  | |  | |.
lycfdhsrvelapqdgkddfynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 324-485 4.5e-10 34.1 In-house 33-199 (290) alignment
Range on Protein: 324-485
Range on HMM: 33-199/290.0
KNTAVTLSGESIADRYINANFIDGYNGMekAYICAQAPIYDT-------IPDFWRMIWECNVNTVVMLCGIFEGGKN----KCAKYWPPPDTNDTEyYGP
   .    |. ..| || ||..   ||.  . |  |.|  ..       | .|| |. . .|. |||||   |  .|     |||| |    ..   .. 
trvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk.fkg

FTVRNNYEEVLPFYKVVYLSVSINsDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTinHTGGPLLVHCR
.||.    |     ..  | |  . || |  |    ..|| .  |.|.   .|.  . |     . | .||| 
ltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcv

subfamily_egg_pd Subfamily egg 328-444 1.1e-17 58.6 In-house 57-174 (307) alignment
Range on Protein: 328-444
Range on HMM: 57-174/307.0
VT--LSGESIADRYINANFIDGYNGMeKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGgkNKCAKYWPPPDTNDTEY-YGPFTVRN--NYEEV
|.  |     .| .| || ..|   .   .|.||||. .|  |||||... .|. .|||    |   ..|  |||  ...   .  | . . |   ... 
vklelrrGqylddfihanrvkGkpll.nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdska

LPFYKVVYLSVsINSDEAERDV
 |...|  | . . .|. || .
dplfrvtklkl.vGgddeerfl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 328-400 2.3e-11 37.7 In-house 81-154 (349) alignment
Range on Protein: 328-400
Range on HMM: 81-154/349.0
VTLSGESIADRYINANFIDGY-NGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWP
 . |  .. | |||||..      .|| ||. |||.  |. ||...|   .|. |. |   .| . .|| .|| 
tsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq

0051429 (Phosphotyrosine protein) phosphatases II 337-485 1e-31 106.0 In-house 4-158 (272) alignment
Range on Protein: 337-485
Range on HMM: 4-158/272.0
DRYINANFIDGYnGM---EKAYICAQAPIYDTIPDFWRMiWECNVNTVVMLCGIFEGGKNKCAKYWP---------PPDTNDTEYYGPFTVRNNYEEVLP
. ||||....|| |    .........|   |. ||||. .| ...|.|.|.. .| |..|| .|||         ..|.  |  || ..|.. .||.|.
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

FYKVVYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAgpILEFQEAVTInhtGGPLLVHCR
.| . .| ...  | .. | ||.. ...|||.|||..|  .||. |..     |||.||||.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCs

0036282 (Phosphotyrosine protein) phosphatases II 337-485 4.5e-23 77.2 In-house 2-112 (174) alignment
Range on Protein: 337-485
Range on HMM: 2-112/174.0
DRYINANFIDGYNGMEkAYICAQAPIYdtipdFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtndteyygpftvrnnyeevlpfykvvylsvsiN
..||||...|..   .  .|. |.|       ||.|..| ...|||||.  .| |. ||  |||                                   .
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

SDEAERDVMLFIFQGWPDFGVPEQAGpILEFQEAVTIN---HTGGPLLVHCR
..  || .. ... .|||.|||. .  .||| ..|      . |||.||||.
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

0046846 (Phosphotyrosine protein) phosphatases II 337-485 6.6e-23 76.8 In-house 12-117 (176) alignment
Range on Protein: 337-485
Range on HMM: 12-117/176.0
DRYINANFIDGYngmekAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTeyygpftvrnnyeevlpfykvvylsvsin
  |||||.|.|.     ..|. |.|...|..||..|..| ....||.|.  .| |. ||. |||   ...                              
ldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

sdeaerdvmLFIFQGWPDFGVPEQaGPILEFQEAVTINH-TGGPLLVHCR
          ... .|||.|||.    .||. |..      ||| ||||.
.........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCs

0051082 (Phosphotyrosine protein) phosphatases II 337-485 7.2e-19 63.3 In-house 3-100 (151) alignment
Range on Protein: 337-485
Range on HMM: 3-100/151.0
DRYINANFIDGYngmekaYICAQAPiydtIPDFWRMIWECNVNTVVMLCGIFEGGknKCAKYWPPPDtndteyygpftvrnnyeevlpfykvvylsvsin
. |||.....|.      ... ..|     .||.....| ...|.|.|.. .| |  .|..|.|  .                                 
sdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

sdeaeRDVMLFIFQGWPDFGVPEQAGPILEFQEAVTiNHTGGPLLVHCR
     ..|. . . .|||.|.|.    .||| |..  .. .||.||||.
.....ievlhipildwpdpglplsfdavleflelll.dkkngpvlvHCs

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 337-456 1.1e-10 35.9 In-house 13-125 (130) alignment
Range on Protein: 337-456
Range on HMM: 13-125/130.0
DRYINANFIdGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEggknkCAKYWPppDTNDTEYY-GPFTVRNNYEEVLPFYKVVYLSVSI
. ||||.|. |  |  . |. .|.|. ||  |||.|. |  || .|.|  . |       .|||  |..  |.|    .|     .   . |  .| .. 
ntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywp..dsePlewyeediivtltdrdefknikasnleies

NSDEAERDVMLFIFQGWPDFG
.  |. . . .|    ||  |
dlneshqaltmfqisnwpsdg

0043147 (Phosphotyrosine protein) phosphatases II 338-485 2.8e-21 71.4 In-house 6-108 (172) alignment
Range on Protein: 338-485
Range on HMM: 6-108/172.0
RYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIfeggknkcakywpppdtndteyygpftvrnnyeevlpfykvvylsvSINS
 ||||...|.|  . . .|. |.|   |..|||||..| .....|.|..                                                 . 
dyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..............................................lydp

DEAERDVMLFIFQGWPDFGVPeQAGPILEFQEAVTI---NHTGGPLLVHCR
.  || .. ... .|||.|||  .  .||| | .     .  ||| ||||.
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs

0044763 (Phosphotyrosine protein) phosphatases II 338-485 5.1e-18 60.8 In-house 19-118 (178) alignment
Range on Protein: 338-485
Range on HMM: 19-118/178.0
RYINANFIDGYngmekAYICAQAPiydtiPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTndteyygpftvrnnyeevlpfykvvylsvsins
.||||..|...      |.... |     .|......| .....|.|.. .|.|..|| .|||                                     
dyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................................

deaerdvMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
       . ... ..||.|||.    .||| |..       ||| ||||.
.......iqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 345-484 5.9e-12 39.6 In-house 83-228 (302) alignment
Range on Protein: 345-484
Range on HMM: 83-228/302.0
IDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTEYYGPFTVR-----NNYEEVL-----PFYKVVYLSVS
.|| . .||       |  .|.  .| .| . ||  || ||.. |....|||.|.   . ...  .| .||.     .. ||        .|.| .    
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd.kvggelkfgrytvktvsvktdleeftdkksfklytveiknek

INSdEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGgpLLVHC
 .. . .. | .. | .||| | |..| . |.         .   .||||
kkk.kvkktvdilafsawpdhGapkeaytaldilkfcesykkn..vlvhc

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 347-428 9.2e-10 32.4 In-house 231-306 (440) alignment
Range on Protein: 347-428
Range on HMM: 231-306/440.0
GYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEggkNKCAKYWPPpDTNDtEYYGPFTVRNNYEEVLPFYKV
||    .|.|..| |.  |. ||||.. . .. |..||  . .   . |. |||  .|     .|||||  .  | .   ||
gys.kknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpv.ntrs.vtfgpftvghkgsenmnrvkv

0049260 (Phosphotyrosine protein) phosphatases II 350-485 5.7e-21 70.2 In-house 6-97 (152) alignment
Range on Protein: 350-485
Range on HMM: 6-97/152.0
GMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWpppdtndteyygpftvrnnyeevlpfykvvylsvsinsdeaerdvmLFIF
.| ...|..|.|   |..|||||..| ...|.|||.  .| || ||..|.                                               ...
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylh

QGWPDFGVPEQAGPILEFQEAVTI--NHTGGPLLVHCR
  |||.|||. .  .|.. ... .   . ||| ||||.
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCs

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 353-459 8e-10 33.2 In-house 5-112 (199) alignment
Range on Protein: 353-459
Range on HMM: 5-112/199.0
KAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifEGGKNKC---AKYWPPPDtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINS--DEAERDVMLF
. ||..| |. .|. |||.|.||     .||.    .  |||    . |||  . . |  || ..|  .   . | | .. | .. |.    . |..  .
rryiatqhplretmadfwqmvwetgsghivmvn...ddqknkeadypfywptte.sgtgkygslsvttktittkpdytitaliltnnttappstreishy

IFQGWPDFGVPE
 |  | .   |.
qftswkekttpn

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 353-459 8.5e-10 33.1 In-house 4-111 (198) alignment
Range on Protein: 353-459
Range on HMM: 4-111/198.0
KAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifEGGKNKC---AKYWPPPDtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINS--DEAERDVMLF
. ||..| |. .|. |||.|.||     .||.    .  |||    . |||  . . |  || ..|  .   . | | .. | .. |.    . |..  .
rryiatqhplretladfwqmvwetgsghivmvn...ddqknkeadypfywptte.sgtgkygslsvttktittkpdytitaliltnnttappstreishy

IFQGWPDFGVPE
 |  | .   |.
qftswkekttpn

subfamily_hpo-7_pd Subfamily hpo-7 362-484 2.2e-08 28.3 In-house 43-161 (263) alignment
Range on Protein: 362-484
Range on HMM: 43-161/263.0
IYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQA
. .||. |...|   . ..|||||   | |..|| .|.|  . ..   .   .|        .  |   |   ..     ..|  . ..||..   ||.|
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl.ekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

GPILEFqeaVTINHTGGPLLVHC
  ||.    . ..    .| |||
reilni...lkvarnskslvvhc

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 365-485 7.9e-11 36.5 In-house 40-156 (255) alignment
Range on Protein: 365-485
Range on HMM: 40-156/255.0
TIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPI
|.  |...|   . ..|||||   | |..|| .|.|  . ..   .   .|        .  . . .   .      ..|  . ..||..   ||.|  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl.ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LEFQEAVTINhtgGPLLVHCR
|.   .|.      ...||| 
lnilkvvrds...ksvvvhCs

0048076 (Phosphotyrosine protein) phosphatases II 405-485 1e-08 30.5 In-house 8-89 (145) alignment
Range on Protein: 405-485
Range on HMM: 8-89/145.0
NDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI-NHTGGPLLVHCR
 .  |.|.... ...|.   .     |... . .  || .. ... .|||.|||. .  .||| |..      ||| ||||.
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCs

0048179 (Phosphotyrosine protein) phosphatases II 406-485 7.3e-08 27.8 In-house 9-91 (144) alignment
Range on Protein: 406-485
Range on HMM: 9-91/144.0
DTEYYGPFTVRNNYEEVL--PFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN-HTGGPLLVHCR
.  |.|.. . ...|.     .. |. |. .   .. || .. ... .|||.|||. .  .||| |..      ||| ||||.
pglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCs

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 420-485 2e-06 21.4 In-house 67-135 (440) alignment
Range on Protein: 420-485
Range on HMM: 67-135/440.0
EEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN---HTGGPLLVHCR
|||    .  |.  |  .    | .  . .||||| |||. |||.|.. . |  .      ||||||| 
eevkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcs

PTPc_DSPc_SM00012 444-485 9.8e-07 24.3 In-house 2-47 (105) alignment
Range on Protein: 444-485
Range on HMM: 2-47/105.0
VMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT----GGPLLVHCR
|. . . ||||.||||.. .|||. .||  |..    ..|..|||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCs