Gene PTPN1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP048_AA protein Get Run
AqueP048_AA_26-164 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 24-68 2.3e-08 28.0 In-house 72-116 (303) alignment 
Range on Protein: 24-68
Range on HMM: 72-116/303.0
WHPLFQVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNK
 |  .   . ..  |||| ||.||.  ||||. ||. | .|.|  
ihasyleldsskkailtqlplshtaadfwqmiieqkvkcvllllt
subfamily_PTPN1_pd Subfamily PTPN1 27-118 5.6e-43 141.7 In-house 63-156 (290) alignment 
Range on Protein: 27-118
Range on HMM: 63-156/290.0
LFQVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEVMFG--RYRIELISIEDYSFFRLSHLQLENV
|...||.||||||||||||.|.||||||||||..|...||||..|....||. |||||..| |...   .....||| |..|......|.|||.
lveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 27-112 1.2e-18 62.0 In-house 68-154 (297) alignment 
Range on Protein: 27-112
Range on HMM: 68-154/297.0
LFQVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIE--DYSFFRLSH
 |  || .  |||.||||  | | ||..|.||. . | |. |  | | .||.||||. ..|     | . .| .|    ..    |. 
vfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe.rlkagdvvveflsstsdefdrvilte
0051082 (Phosphotyrosine protein) phosphatases II 27-159 4.2e-11 38.2 In-house 5-149 (151) alignment 
Range on Protein: 27-159
Range on HMM: 5-149/151.0
LFQVEEVKRSYILTQGPLPhtcdHFWQMVWEQNCKGILMLNKCIERGmnKCYPYWPQ-GqdepevmfgryrielisiedysfF-------------RLSH
..    |   .....|||.    .|.....|...| |..|..  |||  .|. |.|. |                       .              |..
yinfsyvtgglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.......................ievlhipildwpdpglpl

LQ---LENVEIEDTD-DY-----------------------NSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAI
..   || .|. . . ..                         | ..|.|  .|..| |..|...| .| . |.
sfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 28-115 4.1e-22 73.6 In-house 83-168 (288) alignment 
Range on Protein: 28-115
Range on HMM: 83-168/288.0
FQVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDepEVMFGRYRIELISIEDYSFFRLSHLQL
...|. |. || |||||..| ..||..|.|.. . |.||.. .|.| .||  |||....  .. .|   ..|.. ..   | | .| |
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk..pknyGsvtvtlveskeledfvlrklll
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 28-85 6.7e-10 33.5 In-house 75-132 (288) alignment 
Range on Protein: 28-85
Range on HMM: 75-132/288.0
FQVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQ
.  .. ||  | .| ||  | . .|.|. |.. . |.||.. .|.| .|   |.|  .
vssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl
0047943 (Phosphotyrosine protein) phosphatases II 29-161 3.6e-35 117.2 In-house 71-270 (273) alignment 
Range on Protein: 29-161
Range on HMM: 71-270/273.0
QVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEVMFGRYRIELISIEDYSFFRLSHLQLENVEIED------
.. ..|| .|.||||||.|...||.||||||.. | ||....|.|..||..|||. ..| ....|.....|.|.| .. . . .|.|.|.. ..      
dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvth

--------T--D---------------------------------------------------DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQ
                                                                .. | . |..  .|.|| | .|||.|.|| | |.| 
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 29-163 1.2e-32 109.4 In-house 101-304 (307) alignment 
Range on Protein: 29-163
Range on HMM: 101-304/307.0
QVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENV----------
..  .|| .|.||||||.|...||.|.|||... |.||....|.| .||..|||.   . |...|.....|.|.| .. . . .| ...           
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvt

-----EIEDTDDYNS--------------------------------------------------------VEIQEVLLNMRKQRLGLIQTPDQLRFSYV
     .  |..   |                                                        | ..|..  .|.|| | .|.|.|.|| | 
hfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

AILQRI
|.|. .
allell
subfamily_PTPN13_pd Subfamily PTPN13 29-121 6.9e-24 79.6 In-house 71-163 (273) alignment 
Range on Protein: 29-121
Range on HMM: 71-163/273.0
QVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEVMFGRYRIELISIEDYSFFRLSHLQLENVEIE
.|.. . .||..|||||.|.. ||||||||... | |. .  |.|  ||  |||. .... .. .|...||. ..... | ...|.....| .
pvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesg
subfamily_eak_pd Subfamily eak 29-101 9.2e-11 35.7 In-house 87-158 (332) alignment 
Range on Protein: 29-101
Range on HMM: 87-158/332.0
QVEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELIS
.  || | ||||  .       ||||| ||.   |..| . .| ...|   |.|.   | |. || . .|  .
efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre.elkfGildverke
0036941 (Phosphotyrosine protein) phosphatases II 30-167 7e-36 119.4 In-house 73-281 (297) alignment 
Range on Protein: 30-167
Range on HMM: 73-281/297.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEVmFGRYRIELISIED--YSFFRLSHLQLEN----------
. ..|| .|.||||||.|...||.||||||.. |.||....|.|..||..|||  ..|. . .|.....|.|.|   .. . | .|....          
gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslt.ygdftvtllsvevvllddytlrtlevtdtgngesrtvt

----VEIEDTD--------------------------------------------------------DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYV
      . | .                                                         .. | | |... .|.|| | .||..|.|| | 
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye

AILQRIWKRM
|.|. ..|..
allellkkkl
0040439 (Phosphotyrosine protein) phosphatases II 30-163 6.8e-29 96.6 In-house 49-246 (249) alignment 
Range on Protein: 30-163
Range on HMM: 49-246/249.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENVEIED-------
.  .|| .|.||||||.|...||.|.||.... |.||... |.|..||..|||.   . .. .|.....|.|.| .. . . .|.|.|..  .       
gyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

-------TD-----------------------------------------------------DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQR
       ..                                                      .. | ..|..  .|.|| | .|.|.|.|| | |.|. 
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

I
.
l
subfamily_PTPN6_pd Subfamily PTPN6 30-121 2.7e-23 77.4 In-house 93-182 (306) alignment 
Range on Protein: 30-121
Range on HMM: 93-182/306.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEvmFGRYRIELISIEDYSFFRLSHLQLENVEIE
|.. ..||| ||| |..|   ||.|||..|.. |.|. | .||| .||..|||. ....|  .|..... .| .. . . | .|...... .
vkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkk
subfamily_PTPN14_pd Subfamily PTPN14 30-106 2.1e-21 71.2 In-house 88-165 (300) alignment 
Range on Protein: 30-106
Range on HMM: 88-165/300.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQG-QDEPEVMFGRYRIELISIEDYS
|   .|||| .||||..|.  ||||||||. . |.|| . .| | .|.. |.|.  . . .| ||....     || .
vggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 30-99 9.2e-15 49.3 In-house 70-136 (283) alignment 
Range on Protein: 30-99
Range on HMM: 70-136/283.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqdEPEVMFGRYRIEL
 .. .. || .|.|| .|   ||.||....   |.|| |  |    ||  |||.   .  . .| . . |
sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk...rGsedyGeftvtl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 30-98 6.8e-13 42.9 In-house 89-156 (290) alignment 
Range on Protein: 30-98
Range on HMM: 89-156/290.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIE
|. .|  .|||||.|  |   .|.|| ...   | || . || |  || .|.|. . |  . || . . 
vkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe.vltfGeitvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 30-120 1.3e-06 22.1 In-house 86-177 (302) alignment 
Range on Protein: 30-120
Range on HMM: 86-177/302.0
VEEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIEDY--SFFRLSHLQLENVEI
 |...        |   |.. .| .. . |   .  | . .| . .|| .|. .  .. |. |||| .. .|...    |    ...| .|||
tekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgg.elkfgrytvktvsvktdleeftdkksfklytvei
0042113 (Phosphotyrosine protein) phosphatases II 31-161 2.2e-28 94.7 In-house 48-241 (245) alignment 
Range on Protein: 31-161
Range on HMM: 48-241/245.0
EEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENV------------
 .... .|.||||||.|...||.|.||.... |.||... |.|..||..|||.   . .. .|.....|.|.| .. . . .|...|.            
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

--EIEDTD----------------------------------------------------DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQ
   ..| .                                                     .  | ..|..  .|.|| | .|||.|.|| | |.|.
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
DSPc_SM00195 31-119 6.1e-25 83.4 In-house 65-153 (263) alignment 
Range on Protein: 31-119
Range on HMM: 65-153/263.0
EEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQdEPEVMFGRYRIELISIEDYS-FFRLSHLQLENVE
.. |..||.||||||.|...||.||||...| |.||... |.| .||. |||. . . .  ||.....|.. | ..  . | .|.|.. .
ankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkeg
PTPc_SM00194 31-119 6.1e-25 83.4 In-house 65-153 (263) alignment 
Range on Protein: 31-119
Range on HMM: 65-153/263.0
EEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQdEPEVMFGRYRIELISIEDYS-FFRLSHLQLENVE
.. |..||.||||||.|...||.||||...| |.||... |.| .||. |||. . . .  ||.....|.. | ..  . | .|.|.. .
ankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkeg
subfamily_PTPN12_pd Subfamily PTPN12 31-105 1.2e-18 62.1 In-house 79-152 (290) alignment 
Range on Protein: 31-105
Range on HMM: 79-152/290.0
EEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIEDY
 | | .|| .|||||.| | ||.|.||.| . ..|. . .| | .||  |||. ..| |..|| ....|.. .  
vegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee.elefgefevtleeekav
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 31-109 3.9e-13 44.2 In-house 88-162 (297) alignment 
Range on Protein: 31-109
Range on HMM: 88-162/297.0
EEVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMnKCYPYWPqgqDEPEVMFGRYRIELISIEDYSFFR
. .|  .| || | . | . ||.||.... . |.|||.  ||   ||  ||.   |.  . ||   ..| |... . | 
kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs...dkgvttfGdvsvvllsvsereGfi
0050432 (Phosphotyrosine protein) phosphatases II 32-167 1.8e-37 124.7 In-house 105-303 (308) alignment 
Range on Protein: 32-167
Range on HMM: 105-303/308.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEVMFGRYRIELISIEDYSFFRLSHLQLENVEI-----------
 ..| .|.||||||.|...||.||||||.. | ||.|..|.|..||..|||  ...  ...|.....|.|.| .. . . .|.|.|..            
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

----------------------------------------------------EDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQRIWKRM
                                                    |  .  . | ..|..  .|.|| | .|||.|..| | |.|  .....
tnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 32-163 7.3e-36 119.5 In-house 89-286 (288) alignment 
Range on Protein: 32-163
Range on HMM: 89-286/288.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENVEIED---------
. || .|.||||||.|...||.||||||.. | ||.|..|.|..||..|||.   .  ...|.....|.|.| .. . . .|...|... |         
nlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvt

------------T------------------------------------------------DDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQR
                                                             .  . |.. |..  .|.|| |..|||.|.|| | |.|  
hfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

I
.
l
0046845 (Phosphotyrosine protein) phosphatases II 32-167 2.1e-35 117.9 In-house 74-278 (284) alignment 
Range on Protein: 32-167
Range on HMM: 74-278/284.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENVE------------
 .|. .|.||||||.|...||.||||||.. | ||....|.|..||..|||.   .  ...|.....|.|.| .. . . .|.|.|..            
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

-----------------------------------------------------------IEDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAIL
                                                           .| ....  | ..|..  .|.|| | .||..|.|| | |.|
ytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeall

QRIWKRM
  .....
eylklkl
0040438 (Phosphotyrosine protein) phosphatases II 32-169 5e-35 116.7 In-house 83-282 (317) alignment 
Range on Protein: 32-169
Range on HMM: 83-282/317.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENV-------------
. || .|.||||||.|...||.|||||... |.||... |.| .||..|||.   . .. .|.....|.|.| .. . | .|..|.              
nlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhy

---EIEDTD-------------------------------------------------DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQRIWKR
      ..                                                   .. | ..|..  .|.|| | .|||.|.|| | |.|. . ..
tgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

MAD
. .
ltl
0043336 (Phosphotyrosine protein) phosphatases II 32-160 2e-31 104.9 In-house 85-274 (278) alignment 
Range on Protein: 32-160
Range on HMM: 85-274/278.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPqgqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENVEIEDT--------
.|.| .|.||||||.|...||.||||.... |.||... |.|..||..|||    .  . .|.....|...| .. . . .| ..|     .        
nvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy

----------D-----------------------------------------------DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAIL
          .                                               ..  | ..|..  .|.|| | .|||.|.|| | |.|
lgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPRB_pd Subfamily PTPRB 32-117 1.6e-25 84.7 In-house 91-174 (293) alignment 
Range on Protein: 32-117
Range on HMM: 91-174/293.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqDEPEVMFGRYRIELISIEDYSFFRLSHLQLEN
. .| .| ||||||.| |.||.||||.... |.|| ...|.|  ||  |||.  || .|..|  ...|.. |... . . .|..|.
nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa..deepvlyGdikvtlvaeeeledwvirelkiek
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 32-116 4.4e-19 63.6 In-house 70-155 (274) alignment 
Range on Protein: 32-116
Range on HMM: 70-155/274.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDE-PEVMFGRYRIELISIEDYSFFRLSHLQLE
|... |. ||||||.| . ||.|....... |.|| |  |. ..||  |.|. .|   .  .|   |.  .| .   ... .| |.
eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 32-117 1.8e-18 61.5 In-house 61-147 (270) alignment 
Range on Protein: 32-117
Range on HMM: 61-147/270.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDE-PEVMFGRYRIELISIEDYSFFRLSHLQLEN
. |..|| ..|||| |  .||.|.||.. . |.|. .  |.| .||  |||. ..|  ....|  ..  .| |  ....| .|.||.
gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrlee
0036282 (Phosphotyrosine protein) phosphatases II 32-154 1.1e-16 56.4 In-house 14-161 (174) alignment 
Range on Protein: 32-154
Range on HMM: 14-161/174.0
EVKRSYILTQGPLPhtcdhFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpeVMFGRYRIELISIEDYSFFRLSHLQLENVEIEDTDDY-----
.. . .|..||||.     ||.|..|.... ..||....|.|. ||. |||  ..        ...  . ..|.. . || |.    ..|.         
yitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelred..lerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

---------------------------NSVEIQEVLLNMRKQRLGLIQTPDQLRF
                           . |.. ...  .|.|| | .|||.|.||
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 32-117 3.2e-16 54.3 In-house 49-130 (250) alignment 
Range on Protein: 32-117
Range on HMM: 49-130/250.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNkCYPYWPQgqDEPEvMFGRYRIELISIEDYSFFRLSHLQLEN
. ....| |||||..|  .||.||.|.. . |.||..  | . . .  |||   ...|  .|  ...| | | .. .   .|.| .
derkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..ekae.kyGdvtvsllskeefadytkrklklsk
subfamily_CG42327_pd Subfamily CG42327 32-122 1.6e-13 45.0 In-house 69-160 (319) alignment 
Range on Protein: 32-122
Range on HMM: 69-160/319.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPE-VMFGRYRIELISIEDYSFFRLSHLQLENVEIED
. . ||| .| .|  .   ||..||||. . |. | .  | |...|  |.|  .  ..  ..| ... |   |    . .| | | .|. | 
dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkee
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 32-89 1.4e-06 22.6 In-house 32-82 (255) alignment 
Range on Protein: 32-89
Range on HMM: 32-82/255.0
EVKRSYILtqgplphTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPE
. | .|.|       | |.|.|..  .. . . ||    | |..||  |.|  .||  
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 32-98 3.6e-06 20.6 In-house 233-294 (440) alignment 
Range on Protein: 32-98
Range on HMM: 233-294/440.0
EVKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERgmnKCYPYWPQGQdePEVMFGRYRIE
  | ..| || ||  |   ||..| . .   |.|||.  ..    |  |||       | || . . 
skknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt..rsvtfgpftvg
subfamily_hpo-7_pd Subfamily hpo-7 32-89 6.8e-06 20.2 In-house 35-88 (263) alignment 
Range on Protein: 32-89
Range on HMM: 35-88/263.0
EVKRSYILtqgpLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPE
. | .|.|    |  | | |.|..  .. . . ||    | |..||  |.|  .||  
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq
0039614 (Phosphotyrosine protein) phosphatases II 33-163 7.2e-31 103.2 In-house 81-289 (297) alignment 
Range on Protein: 33-163
Range on HMM: 81-289/297.0
V------------------KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMnKCYPYWPQGQDepevMFGRYRIELISIEDYSFFRLSHLQ
|                  .| .|.||||||.|...||.|||||... |.||.|..|.|. ||..|||. ..    ..|.....|...| .. . . .| 
vdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtle

LENveiEDTD--------------------------------------------------------------------DYNSVEIQEVLLNMRKQRLGLI
..|   ..                                                                       .  | ..|..  .|.|| | .
vtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgav

QTPDQLRFSYVAILQRI
|||.|.|| | |.|. .
qtpsqyrflydallell
0037934 (Phosphotyrosine protein) phosphatases II 33-161 6.4e-27 90.1 In-house 43-240 (243) alignment 
Range on Protein: 33-161
Range on HMM: 43-240/243.0
VKRsYILTQGPLPHTCDH----FWQMVWEQNCKGILMLNKCIERGMNKCYPYWPqgqdE-PevMFGRYRIELISIEDYSFFRLSHLQLENVE--------
..| .|.||||||.|...    ||.|.||.... |.||....|.|..||..|||    .    ..|.....|.|.| .. . . .|.|||..        
tpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gev..tygdftvtllseehlddytvrtlllenldlddltrlv

-------IED----T---------DDYN------------------------------------------SVEIQEVLLNMRKQRLG-LIQTPDQLRFSY
       . |    .         |. .                                          .| ..|..  .|.|| |  .|||.|.|| |
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

VAILQ
 |.|.
ealle
Y_phosphatase Protein-tyrosine phosphatase 33-120 1.7e-25 85.2 Pfam-A 40-128 (235) alignment 
Range on Protein: 33-120
Range on HMM: 40-128/235.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELI-SIE-DYSFFRLSHLQLENVEI
 |...|.|||||..|...||.|||....| | ||... |.| .|| .|||. ..| ....|....||  ... | . . |..|.|.. . 
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygdikvelkekekedekeytlrklelkkkke
Y_phosphatase Protein-tyrosine phosphatase 33-120 1.7e-25 85.2 In-house 40-128 (235) alignment 
Range on Protein: 33-120
Range on HMM: 40-128/235.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELI-SIE-DYSFFRLSHLQLENVEI
 |...|.|||||..|...||.|||....| | ||... |.| .|| .|||. ..| ....|....||  ... | . . |..|.|.. . 
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygdikvelkekekedekeytlrklelkkkke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 33-122 1.4e-22 75.2 In-house 87-173 (318) alignment 
Range on Protein: 33-122
Range on HMM: 87-173/318.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQdepEVMFGRYRIELISIEDYSFFRLSHLQLENVEIED
 |..|| .|.|||.|.. ||.||||||.. |.|| .. ||| .|.  |||. .      .|. ..|| .  ..| . | ...... | |.
rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg...srsygklvvelkeevelsdyvlrefkvtrteeee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 33-119 2.1e-21 71.2 In-house 82-166 (281) alignment 
Range on Protein: 33-119
Range on HMM: 82-166/281.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDepEVMFGRYRIELISIEDYSFFRLSHLQLENVE
 .. || ||||.|.....||||||||. . | |. . || |  ||. |||...   |. .| .... .. |. . .   ...||. .
gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns..elkygdvtvkstaeeekatyierkfkleres
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 33-113 2.5e-19 64.4 In-house 43-121 (237) alignment 
Range on Protein: 33-113
Range on HMM: 43-121/237.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqDEPEvMFGRYRIELISIEDYSFFRLSHL
  ..|| .||||  .|| ||||||...|  |.||   ||.   ||. |||.  |.|.  .| . . |   |..| . .  |
tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpa.aygvltvslkkkeefsdytvrsl
0041856 (Phosphotyrosine protein) phosphatases II 33-163 7.3e-18 60.2 In-house 32-171 (182) alignment 
Range on Protein: 33-163
Range on HMM: 32-171/182.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNkciergmnkCYPYWPqgqdepevmfgryrielisiedySFFRLSHLQLENVEIEDTDD-------
  . .|.|||||..|. .|..|..|.... |..|.         ...|||                       ...    .|. .. ..| .        
patrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......................ellerlgiqylylpwpDhgvpdldell

----------------------------------YNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQRI
                                  ...| ..|..  .|..| | ..||.|..| . |.|...
dfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 33-106 1.7e-16 55.0 In-house 90-159 (315) alignment 
Range on Protein: 33-106
Range on HMM: 90-159/315.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqdepEVMFGRYRIELISIEDYS
 || || .|||.. . . ||..|.|...  |.||.. .|.  .|.  |||      .|..|.. . ..| | ..
kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....kviyGkitvtrkseevnt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 33-119 1.9e-14 48.5 In-house 89-173 (325) alignment 
Range on Protein: 33-119
Range on HMM: 89-173/325.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKcIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIEDYSFFRLSHLQLENVE
 |  .. .| ||..| . .|..| . .|  ...||. .. | ..|  |||.   .  . ||  ...|..||..| .    |.. .|.
kkdvflaaqaPltatindlWrlvldWrcsvvvvlne.ldlgkdrcavywpkemgk.sktfGglevklrtieeisdyvhrvldvkqvk
0043147 (Phosphotyrosine protein) phosphatases II 33-156 1.4e-13 46.4 In-house 18-154 (172) alignment 
Range on Protein: 33-156
Range on HMM: 18-154/172.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCiergmnkcypywpqGQDEPEVMFGRYRIELISIEDYSFFrLSHLQLENVEIEDT---------
. ...| |||||..|...||.|..|.... |..|...                | . ..   ...  ....|.. . |. | || .|. |.         
ipdrfiatqgplrntladfwrmlkelgithivnltel..............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

---------------------DdyNSVEIQEVLLNMRKQRLGLIQTPDQLRFSY
                         .. ..|..  .|..| | .|.|.|.|| |
vlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 33-84 5.3e-12 40.0 In-house 79-130 (281) alignment 
Range on Protein: 33-84
Range on HMM: 79-130/281.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQG
.|| |||||||   |   ||.|.|..|   |.|| . .|   .||  |.|. 
lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 33-83 5.7e-12 39.8 In-house 92-142 (310) alignment 
Range on Protein: 33-83
Range on HMM: 92-142/310.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQ
.. ..| .|||| ||   ||.|.... .. ||.| |  | |  ||  ||| 
lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 33-165 1.4e-10 35.2 In-house 86-238 (392) alignment 
Range on Protein: 33-165
Range on HMM: 86-238/392.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIE--RG--MNKCYPY----WPQGQ------------DEPEVMFGRYRIELISIEDYSFFRLSH
 ...|| .||| . . | ||.||...|   | |..|  |  .|  .. .  .    ||. .             | .. ||.|   ||        |   
nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgv

LQLENVEIEDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQRIWK
.   .  .  .     |.. ... |.|..|  ..|| .|  | | |.|. .  
visidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 33-85 2.9e-10 34.0 In-house 105-157 (349) alignment 
Range on Protein: 33-85
Range on HMM: 105-157/349.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQ
|.. || || ||| | | |....  .. | .| ||.  | ...||. || ...
vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
0044763 (Phosphotyrosine protein) phosphatases II 33-154 3.4e-10 35.3 In-house 26-162 (178) alignment 
Range on Protein: 33-154
Range on HMM: 26-162/178.0
VKRSYILTQGPLphtcDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDepevmfgrYRIELISIEDYSFFRLSHLQLENVEIEDTDD-------
.   ..|.. |      .......|.... |..|.. .|.| .||.||||.. .        ..   | |.|.. . |.   || ||. ..         
ilpglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag........iqylhipipDhgvpdllehflefvefieealdekggpv

---------------------YNSVEIQEVLLNMRKQRLgLIQTPDQLRF
                     .... ..|..  .|..|   ...|.|||.
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 33-85 2.9e-09 31.5 In-house 49-101 (239) alignment 
Range on Protein: 33-85
Range on HMM: 49-101/239.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQ
  ..|| ||| .  ..  ||.|.|..    |.||   ||   .||. |||.  
spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 33-84 3.3e-09 31.3 In-house 50-101 (239) alignment 
Range on Protein: 33-84
Range on HMM: 50-101/239.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQG
  ..|| ||| .  ..  ||.|.|..    |.||   ||   .||. |||. 
spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 33-84 2.6e-08 28.2 In-house 70-120 (267) alignment 
Range on Protein: 33-84
Range on HMM: 70-120/267.0
VKRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPywPQ-G
 |. .|.||.||  |  .|.... .|..  | .| |  .  ... .|  |. |
tknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwP..Pkmg
0045098 (Phosphotyrosine protein) phosphatases II 34-163 1.2e-28 95.7 In-house 63-272 (278) alignment 
Range on Protein: 34-163
Range on HMM: 63-272/278.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqdEPEVMFGRYRIELISIEDYSFFRLSHLQLENV---------------
.. .|.||||||.|...||.|.||.... |.||....|.|..||..|||    .  . .|.....|.|.| .. . | .| ..|.               
pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthl

-----EIEDTDDYN--------------------------------------------------------------SVEIQEVLLNMRKQRLG-LIQTPD
     .  .. ...                                                               | ..|..  .|.|| |  .|...
hylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnle

QLRFSYVAILQRI
|.|| | ..|. .
qyrflyefllell
subfamily_PTPRD_pd Subfamily PTPRD 34-119 3e-24 80.6 In-house 90-172 (564) alignment 
Range on Protein: 34-119
Range on HMM: 90-172/564.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqDepEVMFGRYRIELISIEDYSFFRLSHLQLENVE
...|| |||||..|.. ||.||||||.. | ||.|. |.| .||  |||.  .  .  .|.. ..| . |... . . ...|.. .
rkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g..tetygeltVtleeeeeladyeirtfklkkkk
subfamily_PTPN3_pd Subfamily PTPN3 34-119 4.6e-24 79.8 In-house 83-166 (280) alignment 
Range on Protein: 34-119
Range on HMM: 83-166/280.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDepEVMFGRYRIELISIEDYSFFRLSHLQLENVE
   || |||||..|. .||||||||... |.||   .|||  ||. |||. .|  |. .|...... . .  . . | .| |.. |
vnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPeted..eleygefsvkcekedetksyvlrelvlkdke
subfamily_PTPN9_pd Subfamily PTPN9 34-121 3.1e-23 77.3 In-house 84-170 (297) alignment 
Range on Protein: 34-121
Range on HMM: 84-170/297.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIEDYSFFRLSHLQLENVEIE
|...| |||||..|.. ||.|||||..  |.|  ...|||  ||  |||.....    || .... ...| .. .. . |...||. |
kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees.saefgdlsvsnveveeeedykvrvleiknvkte
0051429 (Phosphotyrosine protein) phosphatases II 34-165 7.1e-19 64.0 In-house 21-227 (272) alignment 
Range on Protein: 34-165
Range on HMM: 21-227/272.0
KRSYILTQGPLPHTCDHFWQMvWEQNCKGILMLNKCIERGMNKCYPYWP---------QGQDEPEVMFGRYRIELISIEDYSFFRLSHLQLENV------
.. .....||||.|...||.. .|...| |..| .. |||..||..|||          . ..|.. .|..|. |.|.| .... | .|.|...      
pgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

-----------------------------------------------------EIEDTDDYNSVE--------IQEVLLNMRKQRLGLIQTPDQLRFSYV
                                                      ... ..   |.        ..|..  .|.|| | .||..|..| | 
revmhlhytdwpdhgvpqeallellellldggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

AILQRIWK
|.|. . .
allellrs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 34-119 9.9e-19 62.3 In-house 90-172 (290) alignment 
Range on Protein: 34-119
Range on HMM: 90-172/290.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqDEPEvmFGRYRIELISIEDYSFFRLSHLQLENVE
|..||.||||...|  .||...|....  |.|| . || | .||. |||.  |  .  .| ..|.|.. | .. ..  .|...| .
kkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka..ygefsikllneetlneyierklevknkn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 34-117 2e-18 61.6 In-house 88-170 (305) alignment 
Range on Protein: 34-117
Range on HMM: 88-170/305.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEvMFGRYRIELISIEDYSFFRLSHLQLEN
| .||..||||..| . ||....|   . |.|| | .| | .||. |||. . |..  ||.. .|| | . .| .   .|.. .
kkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekk.efgefsvelksektasdyieRklkisi
subfamily_PTPRA_pd Subfamily PTPRA 34-101 7.4e-18 59.5 In-house 100-164 (330) alignment 
Range on Protein: 34-101
Range on HMM: 100-164/330.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPqgqDEPEVMFGRYRIELIS
| ..| .|||. .| . ||.|.|||.   |.|| .  ||  .||. |||   ||  | .|  |.|.  
kdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP...deGlvtyGnirveved
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 34-118 1.9e-17 58.2 In-house 85-166 (287) alignment 
Range on Protein: 34-118
Range on HMM: 85-166/287.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDepeVMFGRYRIELISIEDYSFFRLSHLQLENV
|. .|....|. .|   ||......| . |.|| .  |   ..|| |||...    |..| |.|||.. | .. .   .|...| 
kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvlGeyniellneevnagyierklevknk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 34-118 2.9e-17 57.9 In-house 98-179 (298) alignment 
Range on Protein: 34-118
Range on HMM: 98-179/298.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpevMFGRYRIELISIEDYSFFRLSHLQLENV
. ..|.||.||..|   ||.||.|.. . | ||..  | .  |.  |||. . |    .|. ...| | |... .   .|.... 
rnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke...tygeitvsllskeefadlivrklkvskk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 34-104 3.7e-17 56.6 In-house 85-154 (515) alignment 
Range on Protein: 34-104
Range on HMM: 85-154/515.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIED
 ..|| .|||.. . | ||..|...|   | |..|  |    ||  |||.   .  | || ...||.|.| 
dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd.svkfGsikvelvslea
subfamily_PTPRN_pd Subfamily PTPRN 34-103 9.6e-17 55.6 In-house 99-165 (297) alignment 
Range on Protein: 34-103
Range on HMM: 99-165/297.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPqgqDEPEVMFGRYRIELISIE
. .|| |||||..|  .|||||||| .  |..| .  | |...|. |||   || . ... | ..|.|  
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp...deGsevyhiyevhlvseh
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 34-104 1.7e-16 55.0 In-house 86-155 (315) alignment 
Range on Protein: 34-104
Range on HMM: 86-155/315.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgQDEPEVMFGRYRIELISIED
 ..|| .||||. . | ||.||....   | |..|  |    ||  |||. ..   | || ...||.|.| 
dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd.rkadsvefGsikvellslea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 34-117 2.7e-15 51.5 In-house 103-177 (319) alignment 
Range on Protein: 34-117
Range on HMM: 103-177/319.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNkciergMNKCYPYWPQGQDEpevMFGRYRIELISIEDYSFFRLSHLQLEN
|  || .||||. | . ||.|.||.||  |..|        .||  |||.  ..     .|. ... |.|. . . . ...| .
kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi...keerfkvkvdsveetaeyvvrdielse
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 34-117 3.1e-15 51.4 In-house 67-141 (284) alignment 
Range on Protein: 34-117
Range on HMM: 67-141/284.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNkciergMNKCYPYWPQGQDEpevMFGRYRIELISIEDYSFFRLSHLQLEN
|  || |||||. | . ||.|.||.||  |..|        .||  |||.  ..     .|..... |.|. . . . ...| .
kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi...keerfkvkvdsveeseeyvvrdielse
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 34-117 5e-15 50.4 In-house 90-170 (319) alignment 
Range on Protein: 34-117
Range on HMM: 90-170/319.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQdepEVMFGRYRIELISIEDYSFFRLSHLQLEN
.. .| ||.|| .| . ||.||||...  ..||.|  |..  |.  |||. .    . .||. ..| . |  . .  ..|.|..
rekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen...feeyGrlivtleeeeeledyiirklklnk
subfamily_Ptp69D_pd Subfamily Ptp69D 34-121 7.8e-15 49.8 In-house 90-174 (307) alignment 
Range on Protein: 34-121
Range on HMM: 90-174/307.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqdePEVMFGRYRIELISIEDYSFFRLSHLQLENVEIE
|...|  |.|.  | . ||.|..||. . | || .  |   .||  |||.     || .|   ..|.| |  | .   .|.. ... |
kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkee
subfamily_CG7180_pd Subfamily CG7180 34-115 1.1e-14 48.7 In-house 84-161 (296) alignment 
Range on Protein: 34-115
Range on HMM: 84-161/296.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMnKCYPYWPQGQdepEVMFGRYRIELISIEDYSFFRLSHLQL
|. || |..|  .| | ||..|...... . .| |  .    ..  |||. .   .  .|   .|... . |. ..   ..|
kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...keqygeifveiveekqyanlkirtfkl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 34-124 7.1e-13 42.9 In-house 84-170 (301) alignment 
Range on Protein: 34-124
Range on HMM: 84-170/301.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEvMFGRYRIELISIEDYSFFRLSHLqleNVEIEDTD
|. .| .|||. .|   ||...|..    |.|. .  |.  .||. |||... | |  ||   ..|..   |  | . .|   || |.|. 
kkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaese.efgpftvtlvneqvyPdfvirql...nvkiqdgs
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 34-85 3.9e-08 27.7 In-house 4-55 (199) alignment 
Range on Protein: 34-85
Range on HMM: 4-55/199.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGmNKCYP-YWPQGQ
.| || || || .|   |||||||     |.|.|       .  || |||  .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknk.eadypfywptte
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 34-85 4.5e-08 27.5 In-house 3-54 (198) alignment 
Range on Protein: 34-85
Range on HMM: 3-54/198.0
KRSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMnKCYP-YWPQGQ
.| || || || .|   |||||||     |.|.|          || |||  .
qrryiatqhplretladfwqmvwetgsghivmvnddqknke.adypfywptte
subfamily_PTPRG_pd Subfamily PTPRG 35-126 6e-22 72.6 In-house 91-179 (563) alignment 
Range on Protein: 35-126
Range on HMM: 91-179/563.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgqDEPEvMFGRYRIELISIEDYSFFRLSHLQLENVEIEDTDDY
. .| |||||..|.| ||.|.|||| . | |. .  ||| .||  |||.  ||.|  .|  .. ||. |  .     .|...|........ 
kafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..dese.tygalqvtlieeevlalytvrtlviknlklkkkkqc
0049260 (Phosphotyrosine protein) phosphatases II 35-156 2e-18 62.0 In-house 9-143 (152) alignment 
Range on Protein: 35-156
Range on HMM: 9-143/152.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWpqgqdepevmfgryRIELISIEDYSFFRLSHLQLENVEIEDT-----------
. .| ||||.|.|...||.|..|.... |.||... |.|  ||. |.              ..  . ..|..   || | |. ... .            
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlV

------------------DdyNSVEIQEVLLNMRKQRLGLIQTPDQLRFSY
                     . |...|..  .|..| | ...|.|||| |
HCsaGvgRtgtlvaaylml..lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPRK_pd Subfamily PTPRK 35-103 2.6e-17 57.6 In-house 86-150 (314) alignment 
Range on Protein: 35-103
Range on HMM: 86-150/314.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPqgqDEPEVmFGRYRIELISIE
. .| |||||..|   ||..|...||  |.||.. .| |  ||. |||   .. || .|  ..||.. |
aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...edtev.ygdikvelvete
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 35-103 6e-16 53.1 In-house 80-146 (287) alignment 
Range on Protein: 35-103
Range on HMM: 80-146/287.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGqDEPeVMFGRYRIELISIE
 ..| .|||.. |   ||..|.|..   .... . .| . .||| |||.  . | .. | | . |.. .
eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evP.mrvGGysvvlldyd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 35-100 7.3e-14 46.1 In-house 96-161 (305) alignment 
Range on Protein: 35-100
Range on HMM: 96-161/305.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEVMFGRYRIELI
. .| .|||| .| |.|| || ... . |.|| | .| |  ||  |||  | |   . .   .| .
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 35-105 2.8e-13 44.5 In-house 75-144 (285) alignment 
Range on Protein: 35-105
Range on HMM: 75-144/285.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIEDY
 .|| |||||| |   ||.|.....   .|||   .| |..||  |.|.   |  | ||.| | |   .. 
styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge.vvkfgkyeitlteckee
subfamily_ptpA1_pd Subfamily ptpA1 35-84 3.1e-13 44.3 In-house 89-138 (418) alignment 
Range on Protein: 35-84
Range on HMM: 89-138/418.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQG
. .| |||||| |   ||.||||. |. |.||..  |    ||  |||. 
kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 35-103 8.6e-13 42.7 In-house 90-157 (301) alignment 
Range on Protein: 35-103
Range on HMM: 90-157/301.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEpEVMFGRYRIELISIE
. .| |||||. |.. || |.   . . | || . .|. ..||  | |.   | ..  ||..|.. . |
hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise.kldigrfkikiknke
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 35-90 5.2e-12 40.4 In-house 82-137 (307) alignment 
Range on Protein: 35-90
Range on HMM: 82-137/307.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEV
. .| .||||  |  .|| |. ... . ..|| |.|| .  ||  |||  . .  |
kkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 35-92 5.2e-11 36.8 In-house 88-144 (305) alignment 
Range on Protein: 35-92
Range on HMM: 88-144/305.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQgQDEPEVMF
. .| || || .||  || | .... . |.|| . .|.| .||. |..  .|.... |
krfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfas.kdkdvlef
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 35-86 4.9e-10 33.4 In-house 91-137 (439) alignment 
Range on Protein: 35-86
Range on HMM: 91-137/439.0
RSYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMnkcypYWPQGQD
. || ||||  .|.|.||..|.|...  |.|| . .|        |||  ..
klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae
0049772 (Phosphotyrosine protein) phosphatases II 35-163 8.2e-10 34.4 In-house 84-280 (314) alignment 
Range on Protein: 35-163
Range on HMM: 84-280/314.0
RSYILTQGPLPHTCDHF----------WQMV--WEQNCKGILM---------------------LNKCIERGmnkcypywpqgQ-----DEPEVMfgryr
...| |||||..|.. |          |.||  ...|.  | |                     |... ..|                 | ..       
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk.....

ielisiEDY---SFFRLSHLQLENVEIEDtDDYN---------------------------------------------SVEIQEVLLNMRKQRL-----
      | .   ..|   .... .. ..| .. .                                              | ..|.|  .|..|      
......eelydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnp

GLIQTPDQLRFSYVAILQRI
|.|....|. | . |.|...
gfieqleqyefilealleyl
subfamily_PTPN23_pd Subfamily PTPN23 36-118 2.9e-16 54.1 In-house 84-165 (288) alignment 
Range on Protein: 36-118
Range on HMM: 84-165/288.0
SYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEvMFGRYRIELISIEDYSFFRLSHLQLENV
..| ||.||. |   ||.||.||  . | || .  |.| .|.  |||. ..|..  || ... | | .. . .   .|.||  
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv.kfgdlsvtlksvretethvervlkletl
subfamily_egg_pd Subfamily egg 36-118 3e-16 54.0 In-house 84-165 (307) alignment 
Range on Protein: 36-118
Range on HMM: 84-165/307.0
SYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERgmNKCYPYWPQGQDEPEVM-FGRYRIELISIEDY--SFFRLSHLQLenV
 .||.| ||  | | ||.||...... |.||.   |   ..|  |||. .... |.  | .||| . ...    .||...|.|  |
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl..v
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 36-122 8.6e-16 52.6 In-house 105-191 (350) alignment 
Range on Protein: 36-122
Range on HMM: 105-191/350.0
SYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEP-EVMFGRYRIELISIEDYSFFRlSHLQLENVEIED
 || ||.||| | | |.... . . | ||.|.. .| ...||| ||..|. .   | .   . . ..|.| | .  .... | .. ..
kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslys.advkkeasdndn
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 36-80 1.8e-07 25.2 In-house 83-127 (312) alignment 
Range on Protein: 36-80
Range on HMM: 83-127/312.0
SYILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPY
 .. |||||  || ||||..    .  |..|   .| | .||  |
rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcaky
0046846 (Phosphotyrosine protein) phosphatases II 37-160 4.4e-18 61.1 In-house 25-170 (176) alignment 
Range on Protein: 37-160
Range on HMM: 25-170/176.0
YILTQGPLPHTCDHFWQMVWEQNCKGILMLNKCIERGMNKCYPYWPQGQDEPEvmfgryRIELISIEDYSFFRLSHLQLENVEIEDTDDYN---------
.| ||||||.|. .|..|..|.... ...|....| |. ||. |||. ...        ..  . ..|..   |..|.    .|..  . .         
piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsa

------------------SVEIQEVLLNMRKQRL-GLIQTPDQLRFSYVAIL
                   . ..|.|  .|.||  | .|||.|.|| | ..|
GigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_PTPN1_pd Subfamily PTPN1 118-171 2e-19 64.4 In-house 226-279 (290) alignment 
Range on Protein: 118-171
Range on HMM: 226-279/290.0
VEIEDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQRIWKRMADAD
|.||..||..||.|..|||..||.|||||||.|||||||.|||. . . . |. 
vliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
subfamily_PTPN9_pd Subfamily PTPN9 120-161 1.7e-06 22.3 In-house 247-288 (297) alignment 
Range on Protein: 120-161
Range on HMM: 247-288/297.0
IEDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQ
..  .. . |...|..  .|.||   ||||.|  | |.|.|.
lsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
DSPc_SM00195 121-161 3.7e-07 25.1 In-house 220-260 (263) alignment 
Range on Protein: 121-161
Range on HMM: 220-260/263.0
EDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQ
.  .... |.|.|.. ..|||| |..|| .|..| | |||.
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 121-161 3.7e-07 25.1 In-house 220-260 (263) alignment 
Range on Protein: 121-161
Range on HMM: 220-260/263.0
EDTDDYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQ
.  .... |.|.|.. ..|||| |..|| .|..| | |||.
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_DSPc_SM00012 123-160 4.4e-06 22.2 In-house 70-104 (105) alignment 
Range on Protein: 123-160
Range on HMM: 70-104/105.0
TddyNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAIL
|   ..|.|....  .|||| |..|| .|  | | |.|
t...kevdifqivkelrkqRpgmvqteeqylflyrall
Y_phosphatase Protein-tyrosine phosphatase 125-160 9.7e-06 20.5 Pfam-A 199-234 (235) alignment 
Range on Protein: 125-160
Range on HMM: 199-234/235.0
DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAIL
. ..|.. ... ..|||| |..|. .|. | | |||
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 125-160 9.7e-06 20.5 In-house 199-234 (235) alignment 
Range on Protein: 125-160
Range on HMM: 199-234/235.0
DYNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAIL
. ..|.. ... ..|||| |..|. .|. | | |||
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN12_pd Subfamily PTPN12 126-172 4.9e-07 23.9 In-house 240-286 (290) alignment 
Range on Protein: 126-172
Range on HMM: 240-286/290.0
YNSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQRIWKRMADADD
 ..... ...|..||||  |.|| .| .. | |... . |...  ..
peeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
subfamily_PTPN13_pd Subfamily PTPN13 127-161 4.4e-06 21.2 In-house 233-267 (273) alignment 
Range on Protein: 127-161
Range on HMM: 233-267/273.0
NSVEIQEVLLNMRKQRLGLIQTPDQLRFSYVAILQ
......|.. ..|.|| |..|| ||  | | |||.
kefdvkeivrklreqrqgvvqtkdqyifvykaile