Gene PTPN12 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP049_AA protein Get Run
AqueP049_AA_15-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051299 (Phosphotyrosine protein) phosphatases II 9-299 1.8e-91 301.9 In-house 4-286 (288) alignment 
Range on Protein: 9-299
Range on HMM: 4-286/288.0
TLKLNEFLDHFMSLAednEENDATFNKEFQALKMESQRykdqntFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEY
 ....|.|.... |      . ... .||..|            ..  ... | |..|||..||||....||.|. ..||||||||||.||.|.. . ..
eisveellklvlkll...angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

IAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQvGESAMYGAIQVTTDHEENvSNDFIIRQLTAE------CQGEKQVIRQFHYTAW
||.|||||.||.|||||.| .......| ...||. . ||  |||. |.| .|| |.||. .||   .|...|.|. .      ..||.. ...||||.|
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnw

PDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
|||| |.|...........|.... .. | ..|||||.|||||.||.| .  .| |.    ..||...|...|.||| ||| ..||.|||.|..|..
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 10-302 2.6e-90 297.4 In-house 7-288 (293) alignment 
Range on Protein: 10-302
Range on HMM: 7-288/293.0
LKLNEFLDHFMSLAEDneeNDATFNKEFQALKMESqryKDQNTfpaESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYI
.||..| .|......|   .|. |..|.. ||      |||..   .. ...||..|||...|||....||.|..... .||||||||||.|   . |.|
iklekfeehvkkmkad...sdlrfseeyeelkavg...kdqav...kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefi

AAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEENvSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPE
|.|||||.||.|||||.| .. .|..|  . ||  | ||. |||.  |. .|| |.||  .||.  .|..||.|. | . |.. .||.|.|.||||| ||
atqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiekekeerkvrqyhftsWpdhgvPe

SATPIIRMIEMFREHR--KRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKktiPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
............||.   . .. |  .||||| ||||| ||.|     . .    | .|.|.||...|..|  .||. .||.|.. ....|....
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 10-306 7.5e-82 269.9 In-house 5-292 (319) alignment 
Range on Protein: 10-306
Range on HMM: 5-292/319.0
LKLNEFLDHFMSLAEdneENDATFNKEFQALKMESQRykdqntfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYI
....|. .... ||.     . ...|||. ||. ..          .| ... ||||||...||... |||.| ...||||||||||..|.| . ....|
ievqeLkerlkalas...tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfi

AAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQvGESAMYGAIQVTTDHEENvSNDFIIRQLTAECQGE---KQVIRQFHYTAWPDHG
|.|.|| .|..|||||.| ... ||.| .. ||  | |.. |||.  .   || . || ..||.  .|.|||.|. . . .      . .|.||.||||.
atqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpe.enfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhd

RPESATPIIRMIEMFREHRKR-HDIPFAIHCSAGCGRTGTIIAIDFartMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTN
 ||.|| .. ...  |. |.. .. |  .||||| ||||| |..|    || .      |||||.|...| ||. |||  .|| |.| |..| |.   |.
vPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivlda...mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte

--V
  |
iev
subfamily_PTPRG_pd Subfamily PTPRG 11-306 4.1e-78 258.0 In-house 2-294 (563) alignment 
Range on Protein: 11-306
Range on HMM: 2-294/563.0
KLNEFLDHFMSLAEDneeNDATFNKEFQALKMESQrykdQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGS-DYINANYIQGPDGNVEYI
...||  | .||  |   .|  |..||.||..|..    .....||. |.| ||.|||  .|.... .||.|... |.... ||||||||.|   . ..|
pvkefakhvaslhad...gdigfseefealqseti....skdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafi

AAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQvGESAMYGAIQVTTDHEENVS----NDFIIRQLTAECQG---EKQVIRQFHYTAW
|.||||..|..||||||| .. .|..|    ||  . ||. |||.  ||  |||.|||  .|| ..    . ..|..|  . .    .....||.||| |
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkW

PDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
|||| ||...| . ...     .|..  |  .||||| ||||| |..|     . ..   .. .|| .....| ||. .||  .||.|.. |..|...  
PdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalleaiask

LTNV
 |..
etel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 13-305 7e-87 286.4 In-house 5-286 (318) alignment 
Range on Protein: 13-305
Range on HMM: 5-286/318.0
NEFLDHFMSLAEdneENDATFNKEFQALKmesqRYKDQNTfPAESgQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQ
... .|   | |   . . ....|...|.    | ... |   .|  .||||.|||. .||... |||.|...||.|||||||||||.|   . .|||||
edleshvrrlre...sGelllseeyerls....rseetvt.slks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaq

GPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGeSAMYGAIQVTTDHEENVSnDFIIRQLTAECQGE--KQVIRQFHYTAWPDHGRPES
.|||.|..|||||.|  .  ...|  .|.| .| |.. |||. | |  ||...|. ..| ..| |...|... . ..|  ....||.|||.|||.| |||
aPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevels.dyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

ATPIIRMIEMFREHR-KRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTN
.. .. ..   ..   |    | ..||||| ||||. ||.|   ..| .      .||| .|.|.|.||..|||. |||.|.| ...| ..   |.
gaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd...illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 13-301 4.3e-64 211.2 In-house 5-285 (290) alignment 
Range on Protein: 13-301
Range on HMM: 5-285/290.0
NEFLDHFMslaEDNEENDATFNKEFQALKMESQrykdqnTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEG--SDYINANYIQGPDGNVEYIA
..| .. .   ... ... .|...|..|.  ..       . .. |  . ||..|||..|.. .  |. |..| | .    .|||| ||.|   . .|||
dkfgefva...nghakgnegfrnqfkmldsges......ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyia

AQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVgESAMYGAIQVTTDHEENVSnDFIIRQLTAECQ---GEKQVIRQFHYTAWPDHG-
.|||...|. |||..|| ... |..| . ..|. | ||| |||.  ....|| ....  .||... ..|.|.|  . .   |.|| . |.. |.|...| 
tqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgk

RPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
 .. .| .. . || . .||| . .  .|||.. ||... .|..   | . |  .    |||......| |.| .||. .|| ...  ... ...
vtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaa...ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 13-299 2.2e-56 186.2 In-house 5-279 (439) alignment 
Range on Protein: 13-299
Range on HMM: 5-279/439.0
NEFLDHFMSLAEDNEEndaTFNKEFQALKMESQRYKDQNTFPAESgqnpVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQ
.|| .|   |  ...|    |...|. ..  |  |. . .. |..     .. |||.||. .|..||| |..| ||  | |||||||.|   .  |||.|
defqehvekldknkqe...ifkeifekinstspdyaciaslaaqe....ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatq

GPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKpkcqcYWPQVGEsAMYGAIQVTTDHEENVSNdFIIRQLTA---ECQGEK-QVIRQFHYTAWPDHGRP
||  .|..||||... ..   ..| .  ||  |     |||  .| ..|| | | .|.. .. | ..|| .       ..|| . . ||||.||||.  |
gpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpn.yvirgfkvfnerdttekertvlqfhyiawpdknvp

ESATPIIRMIEMFREHR-KRHDIPFAIHCSAGCGRTGTIIAIDFARTMLikkTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
  |. .. ..        |.   |  .||||| ||||||||.| |   |    . .|.|.  ||. .||||  ||||| ||||.| |..| .
aqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql...klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0050432 (Phosphotyrosine protein) phosphatases II 16-301 5.5e-89 293.8 In-house 32-301 (308) alignment 
Range on Protein: 16-301
Range on HMM: 32-301/308.0
LDHFMSlaednEENDATFNKEFQALKMESQrykdqnTFPAESGQNPVNKKKNRFKDILPFEYTRVQLhkieGvEGSDYINANYIQGP--DGNVEYIAAQG
| ....       .   ...||..| .          .. .... | ||.|||.|||||....|| |    . ||||||||.|..|.  . . ..||.||
lkllek.....aldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqg

PLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQV--GESAMYGAIQVTTDHEENvSNDFIIRQLTAEC--QGEKQVIRQFHYTAWPDHGRPE
|||.||.|||||.| .......| ...||. ..||  |||    |.| .|| ..||. .||.  .|...|.|. ..   ||  ....||||.||||| |.
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

SATPIIRMIEMFREHRkrHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
|........|. |...   . | ..|||||.|||||.||.| .  .| |.    ..|||..|...|.||| ||| ..||.|.|.|..|... 
speilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_PTPRN_pd Subfamily PTPRN 20-301 7.2e-55 180.8 In-house 18-294 (297) alignment 
Range on Protein: 20-301
Range on HMM: 18-294/297.0
MSLAEDNEENDATFNKEFQALKmesqRYKDQNTfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDG-NVEYIAAQGPLPHT
.|  ||  .|   ..||..||.    .|. ...  .| .... | |||| |..||.. .||.|..    | ||||||  |   |  .  |||.||||..|
lsyledhlknkdrlekewealc....ayeaeps.tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplast

VNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGeSAMYGAIQVTTDHEENVSNDFIIRQLTA--ECQGEKQVIRQFHYTAWPDHGRPESATPIIR
| |||.|.| . . .... .|  |    .|. |||. | |..|.. .|    |   ..|...| .      . | . . |||. .||..| | || ... 
vadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasakslle

MIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
.        .    |  .|||.|.||||. |.||.  . |.|     ..|. . .. .| ||| .|.. ||. |...|..| |..
frrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfefaltavaeevna
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 21-310 1.2e-71 236.6 In-house 24-304 (319) alignment 
Range on Protein: 21-310
Range on HMM: 24-304/319.0
SLAEDNEENDATFNKEFQALKMESQRYKDQNTfpaesGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVN
|  .| ...   .. ||...   .    ||.         . || |||. .||.|. ..|.|....|.|.|||||| ...|   .  ||||||||. |..
snksdfdddltklevefrracklgvnladqtf.....anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntla

DFWRMIWYHQIEIVIMACrevemaKPKCQCYWPQVGESaMYGAIQVTTDHEENvSNDFIIRQLTAECQ---GEKQVIRQFHYTAWPDHGRPESATPIIRM
||||||| ...  ...        | ||  |||. ..   ..  .|  |  |. ......|..    .    ... |.|||.  |||.| |.......|.
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsvee.taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl

IEMFR--EHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLikkTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE--LVQQSLTNVPQLP
..  |  .....|  .  .|||||.||||. |..|    ..      ...||. .|...|.||. .|| | || |.|.|..|  |. .|   .|..|
vkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm...keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfp
subfamily_Ptp69D_pd Subfamily Ptp69D 22-302 1.7e-75 249.0 In-house 13-289 (307) alignment 
Range on Protein: 22-302
Range on HMM: 13-289/307.0
LAEDNEENDATFNKEFQALKMEsqrYKDQNTfpaESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVND
|   ... |  . ||.. |. .     |..|   . ...  |. |||..|| .|. |||.|.||.| | ||||||..|.| . . ..||||.|.  |..|
lksrkrdtdfglakeyekLear...eidkst...kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigD

FWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVgESAMYGAIQVTTDHEENvSNDFIIRQLTAECQG-------EKQVIRQFHYTAWPDHGRPESATPI
|||||.  ......|   . |. . ||. |||.  .   || | |.. .||.  .|.|||.|    ..       ... . |.|||.|.|   ||.|. .
fWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

IRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
...||. ||. | .  |  .||||| ||.|...|.|    .| .    ||.|.| .|...|.||. .|| |.||||.| |...  . .
lklieqvrelyklnrsPivvhCsaGvgrsgifvald...sllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 23-306 1.1e-71 236.5 In-house 14-290 (305) alignment 
Range on Protein: 23-306
Range on HMM: 14-290/305.0
AEDNEENDATFNKEFQALKMEsQRykdqntfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDF
 |.. ..| ........| .| .        . . |.. .||.|||.|.| ...  |..| . | .. ||||||.|..| ... .||.|||||..||.||
kearvysdkgleaqykslyee.ee.......sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf

WRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDHEENvSNDFIIRQLTAEC---QGEKQVIRQFHYTAWPDHGRPESATPIIRMI
||.|.  ... ..| .. ||  | ||. |||. ..|.  .| ..|.   |..  .|.|.|.|..     . |.... |.. | ||||| |..|| ....|
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsli

EMFREHRKRH-DIPFAIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNV
.  ....|.  . |  .||||| ||||. ||.| |   | |    . .||| ...|.|..|. ||| ||||||.. |. ||..   |..
krvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkE...evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 23-302 2.2e-62 205.6 In-house 12-281 (287) alignment 
Range on Protein: 23-302
Range on HMM: 12-281/287.0
AEDNEENDATFNKEFQALKMESQRyKDQNTFPAesgqNPVNKKKNRFKDILPFEYTRVQLHkiegVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDF
|.......  |.. |. |.  .|| .|. |        . ||.|||...||. .  || |.     |  ||||| .|.|   . ..|.|..|. .|. .|
akghakgnegfknqftvleqvtqr.edevthni....asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVgESAMYGAIQVTTDHEEnVSNDFIIRQLTAEC---QGEKQVIRQFHYTAWPDHG-RPESATPIIRMI
|..|. .......| |.| |  . .|  |||.  .| ..|  ...  .|| |....|.|.|  .    .|.|| ..|...|.|...|  .| .| .. . 
WkliddrnvtaivmlcqekendeevcyqyWpee.ksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

EMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
||....||| . .  .|||.. ||... .|..   | . |      .|||......| |.| .||. .|| |.. ...| ..  
emyktqrkrgntsivvhCsdtvGrsamfcaaa...ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_PTPN6_pd Subfamily PTPN6 24-301 9.1e-79 259.6 In-house 19-299 (306) alignment 
Range on Protein: 24-301
Range on HMM: 19-299/306.0
EDNEENDATFNKEFQALKMESqrykDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHkIEGVEGSDYINANYIQ--GPDGNVEYIAAQGPLPHTVND
|... . | |..||..|. |      ....  . |. | ||.|||.| ||||. ||| |.  ..| ||||||||||.   .. . .|||.|| |..||.|
eeeslekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEeNVSNDFIIRQLTAE---CQGEKQVIRQFHYTAWPDHGRPESATPIIRMI
||||.|  . ....|. .||| .| ||  |||.. |. .|| |.||. .| .  .|.|.|.|. .    ..|.. ..|.|...||||| |..   .. ..
FWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EMFREHRKRHD----IPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
|  ......       |  .||||| |||||.| ||    .. || .  ..|. ..|...|.||  .||  .|| |||.|| . ...
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 24-301 1.1e-75 249.7 In-house 20-292 (298) alignment 
Range on Protein: 24-301
Range on HMM: 20-292/298.0
EDNEENDATFNKEFQALKMESQRYKDQNtfpAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFW
 ..... .....||| |.  |.. ....    | ...| ||||||. ||......|| |.|... | |||||| .... .|.  .||.|.||..||.|||
vkkkkkltgyalefqrlnsvsseieeee...kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFW

RMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGeSAMYGAIQVTTDHEEnVSNDFIIRQLTA--ECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMF
||.. ..|. ..|    .|. | |.. |||..| .. || |.|.  ..| .  |.|.|.|.   . . ... .||.|.| |||.| || || .. ...  
rmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvsllske.efadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

REHRKRHD-IPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
| ....    |  ..|||| ||.|| ||||   ..| .  .  ..||| .|. .||.||..||. .||||.|.|. | .. 
rasqqqagnkpvivqCsaGvgRsGtfiaid...svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 24-303 2.3e-73 241.7 In-house 8-280 (281) alignment 
Range on Protein: 24-303
Range on HMM: 8-280/281.0
EDNEENDATFNKEFQALKMEsqrykdQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFW
. .....| | .|...|.        ..  .|.. ... |..|||...|  .. |||.... |  . .||||||...| .|. ||||.|||.|.....||
qlsqndnaGfieeyeklaai......gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEENvSNDFIIRQLTA-ECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMF-
.|.| .......|  ||.|  | ||  |||.  ..  || ..|.. .||. .. .| |...  ...||.. ..|..|||||||| |.... ..   .   
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevl

REHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSL
. ..|....|. |||||| ||||| ||.| .   . ...   .|||  .|...||.|  |||.. || ||| |... ... |
kltekktkaplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 24-113 4.1e-10 33.7 In-house 16-95 (95) alignment 
Range on Protein: 24-113
Range on HMM: 16-95/95.0
EDNEENDATFNKEFQALKMESQRykdqntfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKiegVEGSDYINANYIQGPDGNVEYIAAQG
|   . |  |..||... | |         |   |    |  |||| .|.|.. ||| |        |||||| ...|   .  ||||||
emhsnsdqefdnefksismtsga.......pytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_PTPN12_pd Subfamily PTPN12 25-309 6.9e-141 463.2 In-house 2-287 (290) alignment 
Range on Protein: 25-309
Range on HMM: 2-287/290.0
DNEENDATFNKEFQALKMESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWR
...|....|.||||.||..|..||.......|.|....|.||||.|||||....||.|.|||..|||||||||.|.|..|..||||||||||.|..||||
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWr

MIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAM-YGAIQVTTDHEENVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFRE
|||....|||.|||||||..| ||..|||. ||... .|...||...|..|..||.||.|..|.|.|.....|||||||||||.|.||......||..||
miweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvre

HRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNVPQL
.....|.|...|||||.||||||||||..|..| ...||..||||..|...||||.|.||. .||..||.|..||||..|..... 
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieek
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 25-305 1.3e-82 272.1 In-house 15-286 (288) alignment 
Range on Protein: 25-305
Range on HMM: 15-286/288.0
DNEENDATFNKEFQAL-KMESQRYKdqntfpaESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFW
 . .| . |..|...| ..|... .       . |...||.||||...|||....||.|.| | ..|.|||||.||.| ... .|||.||||..||||||
ksarnrtgfseeynsLaalektksv.......tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEENvSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFRE
.... .... ..|    ||  | ||. |||. ..   || ..||  ....  .||. |.|  | ....  | |..|.|||||| |||..|.. ....   
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveske.ledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkv

HRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKktiPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV-QQSLTN
  .    |. .||||| ||||| ||.| .  .. .    |..||...|...||||. .|| | ||.|.| ....|. ......
anqadtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgvae
subfamily_PTPN23_pd Subfamily PTPN23 25-303 1.6e-58 192.8 In-house 9-284 (288) alignment 
Range on Protein: 25-303
Range on HMM: 9-284/288.0
DNEENDATFNKEFQALKMESQRYKDQNTFPAesgqNPVNKKKNRFKDILPFEYTRVQLHkiegVEGSDYINANYIQGP-DGNVEYIAAQGPLPHTVNDFW
   .. ....|.|. |... ..   ...  .      .. .|||..||||.. .||.|.     .  ||||| ....   |  ..||.|.||. |.||||
kmldgktaldkkfkeleqkqdkearkrsiai....aklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDHEENvSNDFIIRQLTAECQGEK--QVIRQFHYTAWPDHGRPESATPIIRMIEM
.|..  . ....|   . |. |||.. |||.  ||.  .|...||  .... .. .. |.|. | ....  . ..  ..|.||..| |.|   ...... 
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

FRE----HRKRHDIPFAIHCSAGCGRTGTIiAIDFARTMLIkKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSL
 ..    .... ..|  .||||| ||||.. |. .|    . .. .  ||.  .|...|.||  |||  .|. |.| |..| ... |
vesayeavqrksktPlvvhCsaGvgRtgvf.alvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 26-303 8.7e-34 111.7 In-house 1-263 (267) alignment 
Range on Protein: 26-303
Range on HMM: 1-263/267.0
NEENDATFNKEFQALKMESQrykDQNTFPAESGQNpvNKKKNRFKDILPFEYTRVQLHKIEgvegSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRM
||...  ..|||. .|  |.   ...|     ...  |...||. | ||.. ||| | . |     .|||| |..|   .  .|. |.||  |. ||. .
nedeeceiekefelikkisd...tsstisqsiaek..nqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltv

IWYHQIEIVIMACREVEMAKPkcQCYWPQVGESAMYGAIQVTTDHEeNVSNDFIIRQLTAECQGEK-QVIRQFHYTAWPDHGRPE-SATPIIRMieMFRE
|  ... ....  .  .   .  . . |..|..  |  . |    | .  ||. |  |  . . |  . .  ..|  |      .    |.. .  . ..
ihdqkvpvivlltkvftdnir..lfwPPkmgqakkyqdltvehsle.keendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgi..lakn

HRKRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSL
. .  . |. ..||.| ||.|| . ||   ..| .    . .|.|  ....|.||...|.....|....  ..|  .  |
qlengnrPlvvacsdGvGrsGtflvid...sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
subfamily_PTPRD_pd Subfamily PTPRD 28-307 2.1e-97 322.1 In-house 20-289 (564) alignment 
Range on Protein: 28-307
Range on HMM: 20-289/564.0
ENDATFNKEFQALKMEsqrykdqNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIW
..|..|..|.. ....       ..|. |. ..|.||.|||...|.... .|| |.|.||.||||||||..|.| . . .|||.||||..|..|||||.|
nsdlkfeeeykkieeg.......qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvw

YHQIEIVIMACREVEMAKPKCQCYWPQVGeSAMYGAIQVTTDHEENVsNDFIIRQLTA--ECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHR
 .......|  . .|. | ||..|||. | .. || ..||  .||.. .|..||...   . . |.. .||||.|.||||| |||||.....|.  |...
eqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln

KRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNVP
...  |  .||||| ||||| |.||    || . .  ...|....|...||||.||||  .||.|.. ||.| ..   |.|.
epdagPivVhCSaGVGRTGtfivid...amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 28-298 4.4e-55 181.5 In-house 7-276 (287) alignment 
Range on Protein: 28-298
Range on HMM: 7-276/287.0
ENDATFNKEFQALKMESqrykDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHkIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIW
.     .||..||| .|    .  |.   . ..  . ||||. |.||.. ||| |   ||  |||||||||. .   . ..||||||.. ||.||||...
rvkddvdkevdalkeds....esstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravl

YHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEENVSNDFIIRQLT-AECQGEK-QVIRQFHYTAWPDHGRPESATPIIRMIEMFREH-
 ..   ||.  |||| |. ||  |||.     . |   |.    .. . .. .| |  .. .... .|..|... .|||.. . .|  .||..   ..| 
etrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhi

---RKRHD-IPFAIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
   |.  .  |  .|...| ||.|...|.     .| .     ..||  .| ..|..| |.|||  |. ..| |.|  
elardasevGPlvvhddvGiGrsGillatlvlvsrledl...Grvdvaavvirlreyraalvqavvqlrllyealvty
0045450 (Phosphotyrosine protein) phosphatases II 29-299 5.9e-85 281.0 In-house 25-304 (307) alignment 
Range on Protein: 29-299
Range on HMM: 25-304/307.0
NDATFNKEFQalkmESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGV-EGSDYINANYI--------QGPDGNVEYIAAQGPLPHTV
. . . |||.    . ......  .. .... |.||.|||.|||||...|||.|. ..|  |.||||||.|.        .|.| . ..||.|||||.||
fltgllkefe....kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

NDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEENvSNDFIIRQLTAE---CQGEKQVIRQFHYTAWPDHGRPESATPIIR
.|||||.| .......| ...||....||  |||. ||. .|| ..||.  ||   .....|.|. .     ||   ...||||.||||| |.|  ....
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

MIEMFREHRKR--HDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
.||. |.....   . | ..|||||.|||||.||.. . ..| |  .   .|....|...|.||| .|| ..||.|.|.|. ||.
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 29-298 8.7e-85 279.8 In-house 10-271 (273) alignment 
Range on Protein: 29-298
Range on HMM: 10-271/273.0
NDATFNKEFQALKMESQrykdqnTFPAESGQNPVNKKKNRFKDILPFEYTRVQLhkieGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWY
. ... .||..|.           .. . .. | ||.|||.|||||....|| |    | .|||||||.|..|.. . ..||.|||||.||.|||||.| 
gltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

HQIEIVIMACREVEMAKPKCQCYWPQVGE--SAMYGAIQVTTDHEENvSNDFIIRQLTAEC--QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREH
.......| ...||. ..||  |||. |.  | .|| ..||.  ||.  .|...|.|. .    ||. ....|||| ||||| |.| ......||. |..
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

RKR--HDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
..   .. | ..|||||.|||||.||.| .  .|.|.    ..||...|...|.||| ||| ..||.|.|.|..|.
lealpsngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 29-305 5.5e-26 85.7 In-house 15-291 (302) alignment 
Range on Protein: 29-305
Range on HMM: 15-291/302.0
NDATFNKEFQALKMESQrYKDQNTFPAESGQNPV---NKKKNRFKDILPFEYTRVQLHKiegvEGSDYINANYIQGPDGNVEYIAAQGPLPHTV---NDF
.  ...|.... ..... .|  .|. ..  . ..   | |||. .|.   . ..|.|..    |  .|.||  .. |. . . | || |   ..   ..|
eakklvksldtaevkke.fkkidtmkvdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeF

WRMIWYHQIEIVIMACREVEMAKpKCQCYWP-QVGESAMYGAIQVTTDHE---ENVSNDFIIRQLTAECQgEKQVIRQFHYTAWPDHGRPESATPIIRMI
|||.. ..|  | .. .| |. |   . ..| . |.   ||.. | .      |.  . ..|  |  .|  .  ..   . | |...  |.. . .|. .
Wrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcs.nsvlanvyvltnWkqkkvpvkyaelikta

EMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPdklDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTN
.   ..    | . .|    |.|| |....   | . | |.  |    .  ||...|.|||..|..|.|||..|.|.. .... .|.
akvfakkikadentvivSknGaGRagafltlavaveklqkgkep...nikeivksiRsqRpravdslkQyvslyialllyikkkvtk
subfamily_PTPRA_pd Subfamily PTPRA 31-298 5.8e-73 240.6 In-house 32-294 (330) alignment 
Range on Protein: 31-298
Range on HMM: 32-294/330.0
ATFNKEFQALKMEsqryKDQNTFpaESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQ
  | .||.||       . |.|.  |  ..  ||.|||. .|||....|| | ..|||| |||||| .|.|     ..||||||. .||.||||||| ..
klfreefnalPag....piqatl..elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqk

IEIVIMACREVEMAKPKCQCYWPQVGeSAMYGAIQVTTDHEENVS----NDFIIRQLTAECQ-GEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHR
   ..|     |  . ||. |||. | .  || |.|. ..|. .      .|...||. ...  .....||||.|.||| | |  .  ......  .. .
sativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln

KRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
...  |  .||||| ||||| |..|   ..| .     |.||| .|...|.||| |||.. ||.|.| .. | 
qqsagpivvhcsaGvGrtGtfivld...avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 31-305 5.5e-51 168.2 In-house 20-242 (392) alignment 
Range on Protein: 31-305
Range on HMM: 20-242/392.0
ATFNKEFQALkmesqryKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQ
| | .||. |        . . .|  ..|...|.||||.|.|||.. .||.|  |. .  |||.|| ||.. | .  |||.||| . ...|||||.. ..
alffeefhdl.......pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqen

IEIVIMACREVEMAkpkcqcywpqvgesamygaiqvttdheenvsndfiirqltaecQG-EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHD
.  ..|  .  |                                             .| ... . |||.| |||.. |. .. ....|.  . .  .. 
vttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt

IPFAIHCSAGCGRTGTIIAIDFARTmLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTN
 |. |||||| |||| .|.||   .   |||    .||| .| ..|..|| |||. .|| |.| |..| .    | 
hpliihcsagvgrtgvvisidsvva.hakkt..rmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 32-297 9.1e-42 138.1 In-house 10-275 (307) alignment 
Range on Protein: 32-297
Range on HMM: 10-275/307.0
TFNKEFQALKMESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLhKIEGVeGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQI
|..|  |||. | .   ...           | .|||..|.   . .|. . |..|.  |||| |||.        .|.|||||  |. .|| |.  ...
tldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekv

EIVIMACREVEMAKPKCQCYWPQV-GESAMYGA----IQVTTDHEENVSN--DFI-IRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFRE
| ||| |. .|.|| ||. ||| . |.  ..|     | |.    ....   |.| . .|  .  .. . |... .. |||.| |.     | ..|  | 
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry

HRKrhdiPFAIHCSAGCGRTGTIIAIDFARTMLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
..     |  .||||| ||.|||.|| . .  .|.    .  |.  .|...|.||.  .|.  ||....  ..|
dtn....pvvvhcsaGvGrsGtivaislvqdkmiaGi..nckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 32-300 2.8e-37 123.1 In-house 16-288 (305) alignment 
Range on Protein: 32-300
Range on HMM: 16-288/305.0
TFNKEFQALKMESQRYKDQNTFP-AESGQNPVNKKKNRFKDILPFEYTRVQLhkiEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQ
|..|  . |. | .  |  | |   .. ..  ...|||.||.  ..  ||.|   ||    .|| |||.  |     .| .| || .|  ||| | . ..
tlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdk

IEIVIMACREVEMAKPKCQCYWPQVGESAMY---GAIQVTTDHEENV--------SNDFIIRQLTAECQGEK-QVIRQFHYTAWPDHGRPESATPIIRMI
.| ..| |  .|    ||. |..   .  .    .  ...   |  |        . .    .|. |  ||| . . ..|.  ||| | | . . |. ..
veaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell

EMFREHRkrhdIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDvfSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
|  |  .     | ..||||| ||||... ...    |.   | .. |   |.|..|.||   .|. .||.||.  |.. ..
ekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtd..kilqkireqrnnsiqtdaqylfvhqvilnyfr
0036941 (Phosphotyrosine protein) phosphatases II 33-305 1e-86 286.3 In-house 15-283 (297) alignment 
Range on Protein: 33-305
Range on HMM: 15-283/297.0
FNKEFQALkmesqrYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLhkieGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIE
. |||. |      .. .. .. . ...| |..|||.|||||...|||.|    . ||||||||.|..|.| . ..||.|||||.||.|||||.| ....
llkefeel......lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

IVIMACREVEMAKPKCQCYWPQV-GESAMYGAIQVTTDHEENV-SNDFIIRQLTAEC--QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKR-
...| ...||. ..||. |||   |||  || ..||. ..| | ..|...|.|. ..   ||. ....|||| ||||| |||.......||..|...|  
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-HDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTN
  . |  .|||||.||.||.||.| .  .| .|..  ..|....|...|.||| .|| |.||.|.|.|. ||..  || 
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
DSPc_SM00195 33-299 6.7e-86 283.2 In-house 2-262 (263) alignment 
Range on Protein: 33-299
Range on HMM: 2-262/263.0
FNKEFQALKMESQRYkdqntfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIE
...||. |... .        . .... . ||.|||.|.|||.. |||.|.|.|. |||||||||||.|.. . .|||.|||||.||.|||||.| ....
lkeefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

IVIMACREVEMAKPKCQCYWPQV-GESAMYGAIQVTTDHEENVSNDFIIRQLTAECQG--EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHD
|..| ..|.|  | ||. |||.  |..  .| |.|.. ..|......|.|.|. . .|  |.. ..|..|..||||| |.|................. .
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

IPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
 |  .|||||.|||||...||..   | ...    .|.|.||...||||| ||| |.|| |.|.||.|..
gpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 33-299 6.7e-86 283.2 In-house 2-262 (263) alignment 
Range on Protein: 33-299
Range on HMM: 2-262/263.0
FNKEFQALKMESQRYkdqntfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIE
...||. |... .        . .... . ||.|||.|.|||.. |||.|.|.|. |||||||||||.|.. . .|||.|||||.||.|||||.| ....
lkeefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

IVIMACREVEMAKPKCQCYWPQV-GESAMYGAIQVTTDHEENVSNDFIIRQLTAECQG--EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHD
|..| ..|.|  | ||. |||.  |..  .| |.|.. ..|......|.|.|. . .|  |.. ..|..|..||||| |.|................. .
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

IPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
 |  .|||||.|||||...||..   | ...    .|.|.||...||||| ||| |.|| |.|.||.|..
gpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 34-302 4.9e-89 293.7 In-house 3-277 (284) alignment 
Range on Protein: 34-302
Range on HMM: 3-277/284.0
NKEFQALKMESQRykdqNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGV-EGSDYINANYIQGP-----DGNVEYIAAQGPLPHTVNDFWRMIW
 .||..| .         ... . .. | |..|||.|||||....|| |. ..|  |.||||||.|..|.     . . ..||.|||||.||.|||||.|
eeefeellsltvk....lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvw

YHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEENvSNDFIIRQLTAEC---QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREH
 .......| ...||. . ||  |||. ||. .|| ..||. .||.  .|...| |. ..    ||   ...||||.||||| |.|.......... ||.
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrel

RK--RHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
..    . | ..|||||.|||||.||.| . ..|.|. .. ..||...|...|.||| ||| |.||.|||.|..|...  
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0043336 (Phosphotyrosine protein) phosphatases II 34-298 8.5e-85 279.8 In-house 16-276 (278) alignment 
Range on Protein: 34-298
Range on HMM: 16-276/278.0
NKEFQALKMESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEI
 .....|. | ... ...... . .. | ||.|||.|||||....||.|. ..|...||||||.|. |.. . ..||.|||||.||.|||||.| .....
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VIMACREVEMAKPKCQCYWPqvGESAMYGAIQVTTDHEENvSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIP
..| ...||. ..||. |||  |.|  || ..||.  ||   .|...|.|. .    ||.. ....||..||||| ||| ..........||...  . |
ivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

FAIHCSAGCGRTGTIIAIDFARTMLIKKTipdKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
 ..|||||.|||||.||.. . ..| |     ..|....|...|.||| .|| ..||.|.|.|. |.
vlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 34-296 6.1e-39 128.5 In-house 27-286 (305) alignment 
Range on Protein: 34-296
Range on HMM: 27-286/305.0
NKEFQALKMESQRYKDQNTFPAESGQNpVNKKKNRFKDILPFEYTRVQLHKIEgveGSDYINANYIQGPD-GNVEYIAAQGPLPHTVNDFWRMIWYHQIE
 .||. |   ..    |..| |.   . ... |||..|.   . . |.|.|      |||| |||.  |   .  .|.||||| .|...|| |.  ...|
reefrglakytrpdmtqvafnanqsad.iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve

IVIMACREVEMAKPKCQCYWPQ-VGESA-MYGAIQV---TTDHEENVSNDFIIRQLTAECQG-EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRk
 ..| |. ||. | ||  |||   ||   . . | |   .  .  .  ..  |  |     | .|  .|....| ||| | |      . ..   |  . 
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.

rhdIPFAIHCSAGCGRTGTIIAIDFARTMLI-KKTIPDkldVFSIVQQMRKQRPAMVQALDQYVFVYMAIV
   .|  .||||| ||||||.||..    .  .|  |    .  .|. .| ||   .|.  ||.|..  ..
...vpivvhcsagigrtgtivaieyilekiaenkpcpp...mpelvkalrdqrafsiqndvqylfihrvml
0040438 (Phosphotyrosine protein) phosphatases II 35-311 3e-90 298.0 In-house 15-288 (317) alignment 
Range on Protein: 35-311
Range on HMM: 15-288/317.0
KEFQALKMESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIV
. |.||. | ... ...  . . .. |.||.|||..||||....||.|. ..|...||||||.|..||. . ..||.|||||.||.|||||.| ......
sdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

IMACREVEMAKPKCQCYWPQvGESAMYGAIQVTTDHEENvSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPF
.| ....|. ..||. |||. ||.  || ..||.  ||   .....|.|. |    .|.  ...||||.||||| |.| .......|. ||...... | 
vmLteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

AIHCSAGCGRTGTIIAIDFARTMLIKKTipdKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNVPQLPP
..|||||.|||||.||.. .  .| |.    ..||...|...|.||| .|| ..||.|.|.|. |...  || .|  ..
lVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
subfamily_PTPN1_pd Subfamily PTPN1 35-299 4.1e-58 191.4 In-house 6-271 (290) alignment 
Range on Protein: 35-299
Range on HMM: 6-271/290.0
KEFQALKMESQryKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGvegsDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIV
. .... .. .  |. . ||... ..| |...||..|. |....|..|.. .     |||||. .. .. . .|| .|||||.||. ||.|.| ..   |
rlykeiyldir..keasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

IMACREVEMAKPKCQCYWPQVGE--SAMYG--AIQVTTdHEENVSNDFIIRQLTAEC--QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHR--K
.|  . ||  . ||. ||||  |  . ..    ..|.   .|.... ...|.|  |     | ..| .||||.||| | ||| .  ....   ||    .
vmlnkvvekeqikcaqywPqgeeekellledtklkvkl.iseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls

RHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
..  |  |||||| ||.||.. .|     . ||   . .|.   . ..||.|  ..|. ||  | |.||.| .
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
0039614 (Phosphotyrosine protein) phosphatases II 37-303 4.7e-84 277.6 In-house 31-293 (297) alignment 
Range on Protein: 37-303
Range on HMM: 31-293/297.0
FQALKMESQRYKDQNTfPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGV-EGSDYINANYIQGPDG-NVEYIAAQGPLPHTVNDFWRMIWYHQIEIV
.. |..| .......  . . .. |.||.|||.|||||....||.|. ..|| ..||||||.|..|.|  . ..||.|||||.||.|||||.| ......
ktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

IMACREVEMAKpKCQCYWPQVGEsaMYGAIQVTTDHEENvSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKR--HDIPF
.| ...||. . ||. |||. |.  .|| ..||.  .|   .....|.|. .  ||   ...|.|| ||||| |.|.. .....|. ||....   . | 
vmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

AIHCSAGCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSL
..|||||.|||||.||.. . ..| |.    ..||...|...|.||| .|| ..||.|.|.|..||... |
lVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 38-302 1.6e-60 199.7 In-house 26-287 (297) alignment 
Range on Protein: 38-302
Range on HMM: 26-287/297.0
QALKMESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGnvEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMA
.  . | .     |..|.   .. || .|.|.|.|||..  ||.|. ..    |||.|| ...|     ..|. | | . ||.|||.|.. .|. ...| 
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

CREVEMAKpKCQCYWPQVGESAmYGAIQVTTDHEENVsNDFIIRQLTAECQG--EKQVIRQFHYTAWPDHGRPE--SATPIIRMIEMF-REHRKRHDIPF
  . |  | ||. ||.. | .. .| . |..   ..  . || |.|. . .    ..|..|.... |||.  ..  ||. .. .|.    .. .. . | 
nddnerdk.kcaryWsdkgvtt.fGdvsvvllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

AIHCSAGCGRTGTIIAIDFARTMlIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
 .||.|| |||| ...||   .  .|..  ...|.| .|...|..|| .||. .|| ||| |..| .   
lvhclaGvGrtgvlltidsvvae.akre..kevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_eak_pd Subfamily eak 39-216 1.7e-11 38.1 In-house 28-198 (332) alignment 
Range on Protein: 39-216
Range on HMM: 28-198/332.0
ALKMESQRYKDQNTFPAESGQNPVNKKKNrFKDILPFEYTRVQLHKIEgVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMAC
 ... ..  . |.    . ..   . ..|   .|.|...  |.|      .   ||||  .. ..   .|| .  .    |  ||.|.   .   ...  
rinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqll

REVEMAKPKCQCYWPQVG-ESAMYGAIQVTTDHEeNVSNDFIIRQLTAECQGEKQVIRQFHYtawpdHGRPESATPIIR
 .||.   | . |.|. . |   .| ..|.. .     | .  |.|  .   |   .  ...     .|  | ..|...
edvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykv.....fGwtettlpkye
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 40-300 7e-45 148.0 In-house 17-294 (301) alignment 
Range on Protein: 40-300
Range on HMM: 17-294/301.0
LKMESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEG--VEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMA
.. . .. |...  ... | .  ||. ||||.| ...  |. |.. .   .   .||||.||.|   . ..||||||. .|. ||||.|| ..   ..| 
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

CREVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDhEENVSNDFIIRQLTAECQG-----------------EKQVIRQFHYTAWPDHGR-PESATPIIRMI
. . | .| ||. |||.   ||  .| ..||   .|.|  ||.||||.   |                  . . . |.. | ||..|  .| .| .  . 
tnlkegtkskceqywpnseaeseefgpftvtlv.neqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvid

EMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
..    .|    |  .|||.. .|.|. .... .       ..    ||| ... .|...| .|. |.||...| .| . .|
dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 42-306 1e-66 220.1 In-house 19-283 (515) alignment 
Range on Protein: 42-306
Range on HMM: 19-283/515.0
MESQRYKD---QNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMAC
. |. ..|    | .|    |. .| ||||.|.|||.. .||.|  |.    |||.|| ||.. | .  |||.|||.. .|.||||... ...  ..|  
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

REVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDHEENvSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCS
.  |  | ||  |||.  |.|  .| |.| .   |    . |.|.||   . . . . |||.| |||.| |. .. ....|   .  . .   |. ||||
klkegdkikcgkyWPdkpgdsvkfGsikvelvslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcs

AGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNV
|| |||| .|.||    .. .    . .||| .|...|..|| .||. .|| |.| |. | .    | .
aGvGrtGvvisid...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntli
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 43-300 3.2e-65 215.0 In-house 24-278 (315) alignment 
Range on Protein: 43-300
Range on HMM: 24-278/315.0
ESQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVE
| .   | ....  ......| ||||.|.|||.. .||.|  |.    |||||| ||.. | .  |||.||||. .|.|||||.. ...  ..|     |
efhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqe

MAKPKCQCYWPQ-VGESAMYGAIQVTTDHEENvSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCG
  | ||. |||.  ..|. .|.|.|..   |    | ..|.|.     |.. . ||..| |||.| .. .. ....|   .  ..... .. .||||| |
gdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvG

RTGTIIAIDFARTmLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
||| .|.||      ||.|  . .||| .|...|..|| .||. ..| |.| |. | ..
rtGvvisidevva.qikrt..rsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN3_pd Subfamily PTPN3 44-301 1.1e-67 222.9 In-house 22-277 (280) alignment 
Range on Protein: 44-301
Range on HMM: 22-277/280.0
SQRYKDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEgvEgsDYINANYIQG--PD--GNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACR
 | |. ..    .  . | | .|||..||||.. |||.|.. |     |||||||..   |     . |||.||||..|..|||.|.| .......|   
eqlyrkkpglaisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

EVEMAKPKCQCYWPQVGESAMYGAIQVTTDHEeNVSNDFIIRQLTAECQG--EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCS
 ||  . ||  |||. ...  || ..|.  .| . .. ...|.|. . .   |.. | |. |.|||||| |.... .....|  |. |. .. |  .|||
lverGrvkChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCs

AGCGRTGTIIAIDFARTmLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
|| |||| .|... | . || ..  ... .  ||..|| || ..||. .|| ||  ||... ..
aGigrtGvlilletala.lieaa..epvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 46-298 1.5e-46 153.6 In-house 19-265 (283) alignment 
Range on Protein: 46-298
Range on HMM: 19-265/283.0
RYKDQNTFPAESGQnpvNKKKNRFKDILPFEYTRVQLHKIEGvegsDYINANYIQ---GPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVE
   |...  | . .   ||.|||...|.| .  ||.|.        ||||| .|      . . .||.||.|| .|| |||.|.. ..|  ..|  .  |
svpdldadiasade...nkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

MAKPKCQCYWPQVGeSAMYGAIQVTTdHEENVSNDFIIRQLTAECQ---GEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAG
  . ||  |||. | |  ||   ||  ..|  || |||..|.   .    .. ..  . .  | . |       ....  .    .. .. |  .|||.|
dlrikCsqyWPkrG.sedyGeftvtl.rkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstg

CGRTGTIIAIDFARTMLIKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
 |||.. ||.  .   .  ...   .|||..|. ||.||. .||.|||| .|. ...| 
iGrtavfiaasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 47-212 2.7e-06 20.4 In-house 14-159 (169) alignment 
Range on Protein: 47-212
Range on HMM: 14-159/169.0
YKDQNTFPAESGqnpVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINAnyiqgpdgnveyiaaqgplphtvndfwRMIWYHQIEIVIMAC--REVEMA
  . | | ||     .|. |||    |   .|||.|...    |||||||                           ||||  .  ....     . .  
tieynnfmaelt...cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnf

KPKCQCY--WPQVGESAMY-GAIQVTTDHEENVSND----FIIRQLTAECQGEKQ-VIRQFHYTAWPDHGRPESAT
 |. . |   | |     |  .. | ||. .  ..     | .  .  . . .    .. .||..||. | |.|  
wpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 48-212 2.7e-06 20.3 In-house 14-158 (169) alignment 
Range on Protein: 48-212
Range on HMM: 14-158/169.0
KDQNTFPAESGqnpVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINAnyiqgpdgnveyiaaqgplphtvndfwRMIWYHQIEIVIMAC--REVEMAK
 . | | ||     .|. |||    |   .|||.|...    |||||||                           ||||  .  ....     . .   
ieynnfmaelt...cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfw

PKCQCY--WPQVGESAMY-GAIQVTTDHEE-NVS---NDFIIRQLTAECQGEKQV-IRQFHYTAWPDHGRPESAT
|. . |   | |     |  .. | ||. . |.|     | .  .  . . .  . .. .||..||. | |.|  
pekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 48-135 2.9e-06 21.0 In-house 19-105 (332) alignment 
Range on Protein: 48-135
Range on HMM: 19-105/332.0
KDQNTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEgsDYINANYIQGPDGNVEYIAAQGPLP-HTVNDFWRMIWYHQIEIVI
    |.|    .   |   ||   .  |...||.|   .| .  |. ||....|   .  || || |.  ||   ||||.  ..  ...
tsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmil
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 51-300 2.8e-63 208.8 In-house 37-280 (315) alignment 
Range on Protein: 51-300
Range on HMM: 37-280/315.0
NTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQC
. .| .  ..  ||.|||. .|.... .||||  .|  ..|||.|||.|.| . .  |||||||.. .|.||||... ..|  ..|    ||  | |.. 
qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek

YWPQVgeSAMYGAIQVTTDHEEnVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAID
|||      .|| | ||   || | ... .| |.   . . . . |.|||.||| | |....|.. .|   . |..    .  .||||| ||||| |..|
ywpdk..kviyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld

farTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
   ..| .  . . .||. .....|..|  |||...|| |.| |..| . 
...avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 51-301 8.1e-38 125.1 In-house 30-274 (288) alignment 
Range on Protein: 51-301
Range on HMM: 30-274/288.0
NTFPAESGQNPV-NKKKNRFKDILPFEYTRVQLHkiegVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQ
|  . .. .. . |  ..|....   ..|||.|.     .   ||.|| .     .   | || ||  |.. .|.|.   ..| ..| |. .|  |.| .
neasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksa

CYWP-QVGESAMYGAI-QVTTDHEENVSNDFIIRQLTAECQGEKQV-IRQFHYTAWPDHGRPESATPIIRMIEMFREHRKrhdiPFAIHCSAGCGRTGTI
 |.| ..||.| .| . .|. .. ...     .  |  . .||..| ... |.  |.|.| ||.  . .|..|......|    |  .|.||| |||||.
eyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtl

IAIDFARTMLikkTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIV-ELVQQ
| | .| ..|    ..| | . |.....|..|   .|.  ||..|.  .  ||...
ililialesl...rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-102 2.6e-09 30.9 In-house 35-86 (440) alignment 
Range on Protein: 51-102
Range on HMM: 35-86/440.0
NTFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGP
 . |..    | || |||...|| ....|| |....||  |||||| ||.| 
lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_egg_pd Subfamily egg 52-301 3.1e-31 103.2 In-house 29-272 (307) alignment 
Range on Protein: 52-301
Range on HMM: 29-272/307.0
TFPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMakPKCQCY
  . .   .  |..| | | .   ...||.|.  .|    |.| ||...|     |.| || ||  ||.|||||..  ... ..|    .|    .|. |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPQV-GESAMY--GAIQVTTDHEEN-VSNDFIIRQLTAecQGEKqvIRQFHYTAWpdHGRPESATPIIRMIEMFREHRKRhDIPFAIHCSAGCGRTGTII
||.   .|...  |...... . ..     | . .|     | .    . .   |   |  . .. .   ....|  |.    |  ...  |. ...|..
wpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgd..deerflehw..qgdvnnssdvysplrvlrklrnl.skpvvvqdilGvskaatlv

AIDFARTMLIKKTIpDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
||. |   |..  |  |  |   |. .|..|.  |..  .|.|||  .. ....
aieiallsllrGpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 53-307 5.2e-64 211.4 In-house 38-296 (325) alignment 
Range on Protein: 53-307
Range on HMM: 38-296/325.0
FPAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQiEIVIMACREVEMAKPKCQCYW
   .    | ||.|||||...... .|| |   .    ||||||.|..   .   ..||| ||..|.||.||..   .   |..   |..  | .|  ||
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavyw

PQV-GESAMYGAIQVTTDHEENVsNDFIIRQLTA--ECQGEKQVIRQFHYTAWPDHGRP---ESATPIIRMIEMFREHRK---RHDIPFAIHCSAGCGRT
|.  |.|  .|...|     |..  |.. |.|      .|| . ..||.. .|.| | .    .  .|.....   |  .   .   |. .||||| |||
pkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

GTIIAIDFARTMLIKKTipdKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNVP
|. |..  |   .|...   ..|.|  |...||.||.||.. |||...| |.|| .  . |.||
Gvfislysalakviees...rvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvp
subfamily_PTPN13_pd Subfamily PTPN13 54-300 7.9e-69 226.9 In-house 28-270 (273) alignment 
Range on Protein: 54-300
Range on HMM: 28-270/273.0
PAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGvegsdYINANYIQGPDG--NVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCY
 .|.|..  ||.|||....||.. |||.| .  |     ||||..|. | |  . ||||.|||||.||.|||.|.|  . |...|   |.|  | ||. |
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPQVGESAM--YGAIQVTTDHEENVSnDFIIRQLTAEC--QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKrHDIPFAIHCSAGCGRTGTII
||.  .. .  .. ..|.  . .. . .| .|.|. .    || . . ......||||| | ||.......   |. .. .  | ..||||| ||.||.|
wPesknkklkvsnrlevellkvqkld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtli

AIDFARTMLIKKTipdKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
.|| .  .. ...   ..||  ||...|.|| ..||. |||.||| ||.|...
tidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 54-302 5.1e-54 178.3 In-house 40-299 (300) alignment 
Range on Protein: 54-302
Range on HMM: 40-299/300.0
PAESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVeGSDYINANYIQGPDG--NVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCY
  .....|.|..||||||.||.| .||.|   .    ..||||  |. . |  . .||.|||||..||.|||.|.| .......|  .| |  | |.  |
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPQVG---ESAMYGAIQVTTDHEENvSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRH---------DIPFAIHCS
.|. .   ... .|  .|||   |. |. .| ..|. .    .|.. .  . || ||||| ||  .. .  .|...  |..          . |  .|||
fPkleskkktvefgkfkvttkfsed.sdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGCGRTGTIIAIDFartMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
|| |||| .|  |.   ..      ...|. ......|.||  .||.| || ||| .... ...|
aGvGrtGvlilsdl...liatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_ptpA1_pd Subfamily ptpA1 54-248 2.6e-42 140.0 In-house 36-248 (418) alignment 
Range on Protein: 54-248
Range on HMM: 36-248/418.0
PAE--SGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGnVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCY
|.|   |..  |  |||. .||| ..|||||.||.  |||||||||||.|     ..|..||||| |. |||||.|  .  |..|  || | .. ||. |
psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WP-QVGE--SAMYGAIQ-V-TTDHE------ENVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRK------RHDIPFAI
|| |.|    ..||  . |  |         ..   . | |..    .|| . | |..|  ||||  |. . |. ...    ....       ...|  .
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGCGRTGTIIA
||||| |||||. .
hcsagvgrtgtfct
subfamily_PTPRK_pd Subfamily PTPRK 55-312 3e-66 218.4 In-house 35-290 (314) alignment 
Range on Protein: 55-312
Range on HMM: 35-290/314.0
AESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ
 .. ..  |..|||..|||... .||.|. |.|   ||||||..| .     ..|..||||..||.||||... ..   ..|    || .. ||  |||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

VGESamYGAIQVTTDhEENVSNDFIIRQLTAEC----QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAID
 .|   || |.|.   | .. .....| .. |     | |....|||....||||. | ||| .....    .... .. .  .|||||.||||| ||||
dtev..ygdikvelv.etellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

FARTMLIKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNVPQLPPR
    |. .. .   .||| .|...|.... ||.. .||.|.| .|.| .    | .|    .
ivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefk
subfamily_PTPN9_pd Subfamily PTPN9 55-301 3e-65 215.2 In-house 34-292 (297) alignment 
Range on Protein: 55-301
Range on HMM: 34-292/297.0
AESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWP-
..  . ..| .|||..|.| .. |||.| |... | |||||||...|   .  .||.||||..||.|||||.| ... ...|. | ||. . ||. ||| 
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

QVGESAMYGAIQVTTdHEENVSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHR-------------KRHDIPFAIHCSA
. ..|| .| ..|..  | ....|. .|.|...   ..|.. .  | ...|||.| |.||. .. ..|. ||..             . .. |  .||||
eeessaefgdlsvsn.veveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GCGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
| ||||| |..|.. . | ..   ...||.  |...|.||  ..|  .||.| |.|..|  ..
GiGrtGtfitldiclsrleev...gtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
0045098 (Phosphotyrosine protein) phosphatases II 56-300 3e-76 251.7 In-house 26-273 (278) alignment 
Range on Protein: 56-300
Range on HMM: 26-273/278.0
ESGQNPVNKKKNRFKDILPFEYTRVQlhkiegvegsDYINANYIQGPdgNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQv
. .. . |..|||.|||||....||           |||||.||.|.  . ..||.|||||.||.|||||.| ..|....|....||... ||  |||  
tpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

GESAMYGAIQVTTDHEENVsNDFIIRQLTAE------CQGEKQVIRQFHYTAWPDHGRPESA--TPIIRMIEMFREHRKR-------------HDIPFAI
|.|  || ..||.  ||.. .|...| |. .        .|.  ....||. ||||| |..   .......|. ||..|.             .. | ..
ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCSAGCGRTGTIIAIDFARTMLikktiPDKLDVFSIVQQMRKQRPA-MVQALDQYVFVYMAIVELVQ
|||||.|||||..|..  ...|     ....|....|...|.|||  .|| |.||.|.|....||..
HCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 56-301 4e-67 221.2 In-house 21-270 (274) alignment 
Range on Protein: 56-301
Range on HMM: 21-270/274.0
ESGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVE-GSDYINANYIQGPDGNVE-YIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWP
|  . . ...|||.|.||| | .|| |.. .. .  |.|||||||.|.|.. . |.|.|||||.||.||||||.........|  .  |. . ||. |.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

QVGES---AMYGAIQVTTDHEeNVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDI---PFAIHCSAGCGRTGTII
.  .      || .......  .  ||. .|.|. . . ... .  . ||.||||  |..|........  .| |....    |  .||||| ||||  |
daedyeiserygdveikveki.verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

AIDFARTMLIKKTipdKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
||. |   | ...   ..||..|| ..| .|  |||. .|| ... |... ...
aisiavrqlreei...vvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0040439 (Phosphotyrosine protein) phosphatases II 57-299 1.3e-78 259.4 In-house 5-246 (249) alignment 
Range on Protein: 57-299
Range on HMM: 5-246/249.0
SGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQvG
 .. |.||.|||..||||....||.|. ..|...||||||.|| |.. . ..||.|||||.||.|||||.| ..|....|....||. . ||. |||. |
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

ESAMYGAIQVTTDHEENvSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKR--HDIPFAIHCSAGCGRTGTIIAIDFA
.|  || ..||. ..|  ..|...|.|. .    ||.  .....|| ||||| |.|  .....||. |.....   . | ..|||||.|||||.||.. .
gsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

RTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
 ..| |.    ..|....|...|.||| .|| ..||.|.|.|. ||.
leqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 57-299 1.1e-75 249.5 In-house 3-243 (245) alignment 
Range on Protein: 57-299
Range on HMM: 3-243/245.0
SGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQvG
... |.||.|||..||||...|||.|  ..| ..||||||.|. |.. .  .||.|||||.||.|||||.| ..|....| ..|.|. ..||. |||. |
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

ESAMYGAIQVTTDHEENvSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRK-RHDIPFAIHCSAGCGRTGTIIAIDFAR
||  || ..||.  ||.  .|...|.|. .    .|.. ....||. ||||| |..   .....|. |....   . | ..|||||.|||||.||.. . 
esltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

TMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
..| |     .......|...|.||| .|| ..||.|.|.|. ||.
eqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_CG7180_pd Subfamily CG7180 57-299 1.4e-49 163.3 In-house 36-290 (296) alignment 
Range on Protein: 57-299
Range on HMM: 36-290/296.0
SGQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKpKCQCYWPQVG
 | .  |..|||  ...|..|.|| |.|..| | |||||| |...   . |||  ..|  .||..|||... ..|. |.. ... ..|| ... |||. .
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

eSAMYGAIQVTTDHEENVSN----DFIIRQL-------TAECQGEKQVIRQFHYTAWPD-HGRPESATPIIRMIEMFREHRKRH-----DIPFAIHCSAG
  . || | | . .|.. .|     | . .        ... . |. ....|..| |.  .  | |.. .| .... |  |..        |  ...| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

CGRTGTIIAIDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
 .|.|  .||| .  ...|.   ...|||  |...|..|| .|.  ..| ..|  . | |
asRsGvylaidanlelveke...eevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0037934 (Phosphotyrosine protein) phosphatases II 58-298 1.5e-73 242.6 In-house 5-241 (243) alignment 
Range on Protein: 58-298
Range on HMM: 5-241/243.0
GQNPVNKKKNRFKDILPFEYTRVQLhkiegvEGSDYINANYIQGPDGnveYIAAQGPLPHTVND----FWRMIWYHQIEIVIMACREVEMAKPKCQCYWP
.. |.|..|||..||||....|| |      |||||||||.|.....   .|| |||||.||.|    ||||.| ..|....| ...||. . ||  |||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

qvgESAMYGAIQVTTDHEENVsNDFIIRQLTAEC---QGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREH--------RKRHDIPFAIHCSAGCGR
   .. .|| ..||. .||.  .|...| |. |.   ..... ....||..||||| |.| ......... ||.           .. | ..|||||.||
...gevtygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTIIAIDFARTMLikktipdKLDVFSIVQQMRKQRPA-MVQALDQYVFVYMAIVEL
|||.||..   ..|       ..|....|...|.|||  .|| ..||.|.|.|. ||
tGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 58-300 7.2e-68 223.5 In-house 4-243 (250) alignment 
Range on Protein: 58-300
Range on HMM: 4-243/250.0
GQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPkCQCYWPqVGE
...| ||.|||. ||.... .|| |.| .| . |||||| ...| |..  .||.||||..|..|||||.. .... ..|    .|. |  .. ||| | .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vek

SAMYGAIQVTTdHEENVSNDFIIRQLT--AECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKR-HDIPFAIHCSAGCGRTGTIIAIDfarT
.  || ..|.  .....  |...|.|    . . .....||.|...||| | || || .. ...  .  ... .. |  ..|||| ||.|. ||||   .
aekyGdvtvsl.lskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid...a

MLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
.| .  .  ..||| .....||.|| .|..|.||||||..| . ..
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 58-297 3.6e-51 168.6 In-house 3-239 (239) alignment 
Range on Protein: 58-297
Range on HMM: 3-239/239.0
GQNPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNV-EYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVg
 .. ||| |||. .|. ....|| | |.     ||||||.|..  ||.   |||.|| .  .  |||||.|  .  ...|    .|  | ||. |||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

eSAMYGAIQVTTDHEEnVSNDFIIRQLTA--ECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDfarT
 .. |  ..||  . | |  |.||| .      | |.. . |.|.| |||.| |. || .. .     .       |. |||||| ||||... ||   .
.tskycnlrvtlrkte.vfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid...a

MLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
|| .      .|.|  |. .|..|| |||. .||||...|..|
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0049772 (Phosphotyrosine protein) phosphatases II 58-300 3.1e-44 147.3 In-house 41-281 (314) alignment 
Range on Protein: 58-300
Range on HMM: 41-281/314.0
GQNPVNKKKNRFKDILPFEyTRVQLhKIEGVEGSDYINANYIQGPdgnVEYIAAQGPLPHTVNDF----------WRMI--WYHQIEIVIM---------
.. ..|..|||..||||.. .||.| . ..|.|||||||.|. |.     .||.||||..||.||          |||.  . ... .. |         
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------ACREVEMAkpkcqCYWPQVGESAMYgaiqvttdheE-------NvsndfiirqltaecqgeKQVIRQFHYTAWPDHGRPeSATPIIRM
             ..  .       ....      .           |                         .. . ..... .||.. | .   . ..
lsrLdaAlgKtpllildgng.....neptaadlellk..........eelydpelf.................erlgikylripvpDgsap.lledfdef

IEMFREHrkRHDIPFAIHCSAGCGRTGTIIAIDFARTMLikktipdKLDVFSIVQQMRKQRP-----AMVQALDQYVFVYMAIVELVQ
.|...|.  . . |...||.||.||||| .....    |       ....  .....|..||      ... |.||.|...|. |...
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 58-216 1.2e-34 114.5 In-house 28-188 (297) alignment 
Range on Protein: 58-216
Range on HMM: 28-188/297.0
GQNPVNKKKNRFKDILPFEYTRVQLHKieGVEGSDYINANYIQGPDG--NVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQV
 . .   .|||..||| .. |||.| .  .. ..|||||.|.  ||   .. || |||||  ||.|||.... ... ...| ..  |  . ||  |||.|
akrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

GESAMyGAIQVTTDHEENVSNDF---IIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIR
 .  .  | .|  ..  ..|..|   |. .|.   . |..|.|   . .||||| |     . |
vqerl.kagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvr
subfamily_CG42327_pd Subfamily CG42327 58-223 2.4e-27 90.4 In-house 22-192 (319) alignment 
Range on Protein: 58-223
Range on HMM: 22-192/319.0
GQNPV-NKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPD-GNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQV
 . ||  |.|.|. ...|.  ||| |..|   . . |..|.|..|.|  .  ||||| .|  .  ||||..|  |  ... ..   |    .|  |.|  
devPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

---GESAMYGAIQVTTDHEENVSNDFIIRQLTAECQGEKQ-VIRQFHYtAWPDHGRPESATPIIRMIEMFRE
    .  .|| |.||  . |   . .|   |  . ..|.   .  . |  |.. . | . ...| |.   |.
etldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 59-297 1.2e-42 140.5 In-house 33-267 (281) alignment 
Range on Protein: 59-297
Range on HMM: 33-267/281.0
QNPVNKKKNRFKDILPFEYTRVQLHK-IEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGE
..|||.||||. .|  .. .||||.  .   . .||| ||||. |  .  || .|||   |  |||||||  .   ..| |. .|  . ||  |.|.   
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

SAMYGAIQVTTDHEENVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPiirMIEMFREHRKRHdIPFAIHCSAGCGRTGTIIAIDFARTM-L
 ..       .  .  | . ..  .|    .|| ..| .. .  |||   |||.     |....|. | |   |  |||||| ||.||..|.. |     
cclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev...mlkilrkirars.tppvihcsagvgrsgtlmaveialqsih

IKKTIPDkldVFSIVQQMR-KQRPAMVQALDQYVFVYMAIVE
 . |.||   .  || ..|   | | ||.|.||....  ...
shftlpd...ikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 59-206 1e-13 45.5 In-house 92-234 (244) alignment 
Range on Protein: 59-206
Range on HMM: 92-234/244.0
QNPVNKKKNRFKDILPFEYTRVQLHKieGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACrEVEMAkpkcQCYWPQVGES
 || |  |||    |||.. || | |  |  |  |||| ..       ||| .| ||  |  |||.|.    ......    ||      . |||.    
fnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg.sveee....deywpdsepl

AMYG-AIQVT-TDHEENVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHG
  |   | || || .|         .. .. .  .| .  |  . ||  |
ewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 60-297 4.2e-51 168.4 In-house 4-238 (239) alignment 
Range on Protein: 60-297
Range on HMM: 4-238/239.0
NPVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNV-EYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVgeS
. ||| |||. .|. ....|| | |.     ||||||.|..  ||.   |||.|| .  .  |||||.|  .  ...|    .|  | ||. |||.   .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..t

AMYGAIQVTTDHEEnVSNDFIIRQLTA--ECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDfarTML
. |  ..||  . | |  |.||| .      | |.. . |.|.| |||.| |. || .. .     .       |. |||||| ||||... ||   .||
skycnlrvtlrkte.vfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid...aml

IKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
 .      .|.|  |. .|..|| |||. .||||...|..|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 61-302 1.4e-69 229.1 In-house 18-267 (270) alignment 
Range on Protein: 61-302
Range on HMM: 18-267/270.0
PVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGN-VEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGES-
  .|| ||..||||   |||.|...|  . . ||||||..| ||.  .||||.|||| |...|||||| .. . ..|.   .|  . ||..|||.  .. 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

--AMYGAIQVTTDHEENvSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESAT------PIIRMIEMFREHRKRHDI--PFAIHCSAGCGRTGTIIA
   ..| |.|.. .||. .. .|...|. | .||.. .  |.|..||||| |...        ...|..  |...|..|   |. .||||| |||||.||
vkledgkikvlalseek.eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDFARTMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
.|.|  .| ..    |.|| .|....||.|.|.||  .|| |.| |.|| ... 
lDiavrlLeet...kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 61-310 1.6e-69 229.5 In-house 23-268 (284) alignment 
Range on Protein: 61-310
Range on HMM: 23-268/284.0
PVNKKKNRFKDILPFEYTRVQLHKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACrevemaKPKCQCYWPQVGESaM
. || |||. .||.|. ..|.|... |.|.|||||| .|.|   .  |||.||||. |..||||||| ...  ...        | ||  |||. ..   
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.k

YGAIQVTTDHEENvSNDFIIRQLTAECQ---GEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFR--EHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTM
..  .|  |  |. |.....|..    .    ... |||||.  |||.|.|.......|...  |  .....|  .  .|||||.||||. |..|    .
eerfkvkvdsvee.seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE--LVQQSLTNVPQLP
. ..   ...||. .|...|.||. .|| | || |.|.|..|  |. .|   .|..|
mkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 61-102 1.2e-08 28.9 In-house 37-77 (244) alignment 
Range on Protein: 61-102
Range on HMM: 37-77/244.0
PVNKKKNRFKDILPFEYTRVQLHKIeGVEGSDYINANYIQGP
 .|  |||. .||||. ||| |      ||||||||||||| 
sanatknryinilpfdetrvilsss.kkegsdyinanyiqgs
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 62-298 6.9e-37 121.9 In-house 34-269 (285) alignment 
Range on Protein: 62-298
Range on HMM: 34-269/285.0
VNKKKNRFKDILPFEYTRVQLHKIEgvegSDYINANYIQGPDG-NVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESA
 |   ||. |.   | ||| |.. .     ||| |.... |   .  ||..||||| |..|||.||.  .|  |.| |  .|    ||  |.|. .||  
anpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

MYGAIQVT-TDHEENVSNDFIIRQLT----AECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHrKRHDIPFAIHCSAGCGRTGTIIAIDFART
 .|  ..| |. .|.     |.  ||     ..  |   . . .   |||.  || | |.| . .  ..  . .. | ..||||| ||| |.. ||.|  
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidyati

MLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
 ....    ..... ||..||  |   ||.  |..|.|. ..| 
rimen...pniemldivremramrfqavqshmqflflyvvlmey
Y_phosphatase Protein-tyrosine phosphatase 63-297 1.8e-80 265.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 63-297
Range on HMM: 1-235/235.0
NKKKNRFKDILPFEYTRVQLhkiEGVEG-SDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWP-QVGESAM
||||||.|||||.. |||.|   .| || ||||||||..| . . ..||.||||..|..|||||.| .......| ....|. . ||. ||| . .|| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGAIQVTTD-HEENVSNDFIIRQLTAECQGEK---QVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTML
|| |.|..  .|.. ......|.|. . ..|.   . ..|.|||.||||| |||.......|........ .. |  .|||||.|||||..|.|..  .|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

IKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
 ..     .||..||...||||| ||| |.||.|.|.||.|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 63-297 1.8e-80 265.1 In-house 1-235 (235) alignment 
Range on Protein: 63-297
Range on HMM: 1-235/235.0
NKKKNRFKDILPFEYTRVQLhkiEGVEG-SDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWP-QVGESAM
||||||.|||||.. |||.|   .| || ||||||||..| . . ..||.||||..|..|||||.| .......| ....|. . ||. ||| . .|| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGAIQVTTD-HEENVSNDFIIRQLTAECQGEK---QVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTML
|| |.|..  .|.. ......|.|. . ..|.   . ..|.|||.||||| |||.......|........ .. |  .|||||.|||||..|.|..  .|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

IKKTIpdkLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
 ..     .||..||...||||| ||| |.||.|.|.||.|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 63-297 3.3e-52 172.1 In-house 3-237 (237) alignment 
Range on Protein: 63-297
Range on HMM: 3-237/237.0
NKKKNRFKDILPFEYTRVQLHKIEGveGSDYINANYIQGPDGNV-EYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMY
|| |||. .|  ....|| |.   .  |||||||.|..| ||   .||||||||  . .|||.|.|  .  ...|    .|  . ||  |||.  . | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GAIQVTTDHEENVSnDFIIRQLTAECQGEKQ---VIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKR--HDIPFAIHCSAGCGRTGTIIAIDfarTML
| . |.  ..|. | |. .| |.   .....   .| |...|.|||.| |. .. ..|.     .. .   .  |. |||||| |||| .. ||   .||
gvltvslkkkeefs.dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid...aml

IKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
 .      .|..  |. . ..|| ..|. |||||.. .|.|
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 63-306 2.7e-51 169.0 In-house 1-178 (182) alignment 
Range on Protein: 63-306
Range on HMM: 1-178/182.0
NKKKNRFKDILPFEYTRvqlhkiegveGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACrevemakpkCQCYWPqvgesamyg
|..|||..||||....|          ..||||||.. |.  . ..||.||||..||.||.||.. ..| ......         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

aiqvttdheenvsndfiirqltaecQGEKQVIRQFHYTAWPDHGRPEsATPIIRMIEMFREhrkrHDIPFAIHCSAGCGRTGTIIAIDFARTMlikktip
                         . ... . |..|. ||||| |.    ....||. .|    .. | ..|||||.|||||..|... ...       
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

dKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTNV
 .......|...|..|| ||. ..||.|...|. ||.... |..
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 63-298 6.9e-45 147.9 In-house 56-282 (290) alignment 
Range on Protein: 63-298
Range on HMM: 56-282/290.0
NKKKNRFKDILPFEYTRVQLHkiEGVEGsDYINANYIQGPdgNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMY
. ||||.||.   . ||| |.  .| .| ||. |||..|   .  .| .||.|  || |.|||.  ...  ..| |  .|  |.||. |.|.  ||   .
efkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GAIQVTTDHEENVSNDFIIRQLTAE--CQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHrkrhDIPFAIHCSAGCGRTGTIIAIDFARTMLIKK
|.| |.   |..  .. | . |.     .| . ... ..  .|||.  . |.  ..|.. . |.       | ..||||| |||||..||. .  .|.. 
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldG

tipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
    .||.  .|. .|. | . ||   ||. .  ....|
...keldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 63-296 3.7e-35 116.0 In-house 52-287 (310) alignment 
Range on Protein: 63-296
Range on HMM: 52-287/310.0
NKKKNRFKDILPFEYTRVQLhKIEGVEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYG
. .|||. |..  . .||.| ||.     ||| |||..       .| .|||| ||. ||||||.  . | ... |. .|  .|||  ||| .| .  ||
ymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

AIQVTTDHEE-------NVSNDFIIRQLTAECQG---EKQVIRQFHYTAWPDHGRPESATPIIRMIEMfreHRKRHDiPFAIHCSAGCGRTGTIIAIDFA
 |.||   |        |..  |.  ..  . |    ..  .   ..  ||| | |.     .    .    . ||  |  .||||| .|.....|....
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrll...aqvrhg.pcvvhcsagkdrlyvvvalklk

RTmliKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIV
     |    .|.|.  .. ...|.|   .|.  ||... .  .
id...kldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 63-293 2.6e-30 100.2 In-house 50-275 (301) alignment 
Range on Protein: 63-293
Range on HMM: 50-275/301.0
NKKKNRFKDIlPF-EYTRVQLHkIEGVegSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQV-GESAM
.|.|.|.. . |    | |..   .|      | ||.|. .     .||.||||. | .||| |. ....| ..| ...||  . ||. | |.  .|.  
pkdkhryptv.PckPstavevi.vdGk..rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGAIQVTTDHEENVSNDFII-RQLTAECQG---EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKrhdiPFAIHCSAGCGRTGTIIAIDF-ARTM
 |  .... ..| . |. |. |.|  |      . . .  . |. |.|.| |.| . .  ..|. .. .|    |  .||||| ||. . |. .. || .
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylarev

LIKKTIpdklDVFSIVQQMRKQRPAMVQALDQYVFVYM
. ..||    ..   ....|..|   ||   |  .. .
eadpti....eltealkhlrehrwngvqtnsqlywmtl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 63-300 4.8e-24 79.5 In-house 47-280 (303) alignment 
Range on Protein: 63-300
Range on HMM: 47-280/303.0
NKKKNRFKDILPFEYTRVQLHKiegvegSDYINANYIQGpDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYG
| .|||| |.. .....|.|        | || |.|..  | .   | .| ||.||  |||.||   ..  |..   . |. |   .  .|.  .   . 
nmdknrfvdvicldhskvklsd......ssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

--AIQVTTDHEENVSNDFIIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATP-IIRMI-EMFREHRKRHDIPFAI-HCSAGCGRTGTIIAIDFARTMLI
  .|.|   .. .... . .. |.      |  .   || |||    |  ..| ... | ..    ||  |   ..    .||||.||.  .. |   | 
ersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslh

KKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
..     ||.   ....|. |   || | |. .||  . | | 
seq..asldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 63-135 1.1e-09 32.2 In-house 37-114 (347) alignment 
Range on Protein: 63-135
Range on HMM: 37-114/347.0
NKKKNRFKDILPFEYTRVQLHKIEG-----VEGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVI
. .||| ||    . ||| |   .       .   |||| .|.  . . ||| .| |||.|| |||.|.   ..  |.
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 64-167 4.2e-25 83.2 In-house 48-165 (350) alignment 
Range on Protein: 64-167
Range on HMM: 48-165/350.0
KKKNRFKDILPFEYTRVQLH--------KIEGVEGSDYINANYIQGP------DGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQ
  |||.|.|||.| .||.|.        |   ....|||||||.. .      . .  |||.|.||| ||.||...|   .......   .||.   ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

CYWPQVGESAMYGAIQVT
 ||.. . . .   .. .
rYWqegsydditvklask
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 64-300 8.2e-24 78.8 In-house 44-277 (312) alignment 
Range on Protein: 64-300
Range on HMM: 44-277/312.0
KKKNRFKDILPFEYTRVQLHkieGVEgSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGA
|  ||. .|  ..  |  |    | |   || ||...       ....||||  |.  ||..        .|. |  || .  ||  |  ..        
kdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

IQVTTDHEEN-----VSNDFIIR---QLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKrhdiPFAIHCSAGCGRTGTIIAIDfarTM
 .| |..  .      |.| |     ..   . |..  . .. ...||||| |.|     |..   .  .|    |   ||||| |||||.. |.   .|
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlalie...sm

LIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQ
.     | | .|  .   .||.|   |... |||..  ...|.. 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 64-169 2.3e-17 57.4 In-house 49-170 (349) alignment 
Range on Protein: 64-169
Range on HMM: 49-170/349.0
KKKNRFKDILPFEYTRVQLHKI--------------EGVEGSDYINANYIQGPDGNVE--YIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPK
  |||.|||||.|..||.|.|               ..    |||||||.. .  .||  ||| | ||| ||.||...|   ....|.    . | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CQCYWPQVGESAMYGAIQVTTD
|. || .   | .   .| .  
cdiywqelsysnitvklqnssl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 73-206 1.3e-09 32.4 In-house 3-125 (130) alignment 
Range on Protein: 73-206
Range on HMM: 3-125/130.0
LPFEYTRVQlhkiegveGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACrEVEMAkpkcQCYWPQVGESAMYG-AIQVTTDHE
|.||..|.|        | .||||...   .   ||. .| ||  |  |||.|.    ......    ||      . |||.      |   | ||. . 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpdsePlewyeediivtltdr

ENvSNDFIIRQL--TAECQGEKQVIRQFHYTAWPDHG
.. ..     .|    . .  .| .  |. . ||  |
de.fknikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 74-300 1.2e-35 118.1 In-house 1-172 (178) alignment 
Range on Protein: 74-300
Range on HMM: 1-172/178.0
PFEYTRVQLHKIEGVEGSDYINANYIQGPdgnvEYIAAQGPlphtvNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGEsamygaiqvttdheen
|.. ||| |...||.|.||||||..| .      |.....|      |...... . |  ... . |.|. ..||  |||.  .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vsndfiirqltaecqgekqviRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMlikktipdKLDVFSIVQQ
                      |.... .|||| |..   . ...|. .|...... | ..||||| ||.||..|..  ...        .|........
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRKQRPaMVQALDQYVFVYMAIVELVQ
.|..|| .|.  .|. ..|.   .| .
vrerRp.ivpnpgqlrqLyefelrllk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 75-305 1.5e-21 71.8 In-house 30-265 (290) alignment 
Range on Protein: 75-305
Range on HMM: 30-265/290.0
FEYTRVQLHKIEGVEGSDYINANYIQGPDGnVEYIAAQGPLPHT-------VNDFWRMIWYHQIEIVIMACREVEMAKP----KCQCYWPQ-VGESAMYG
.| ||| |.       .||| ||... |.| .. |. | |. ..       ...|| |.   ... |.| |   |  .      |. | |. |||.  ..
veatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

AIQVTTdHEENVSNDFIIRQLTAECQGEKQV-IRQFHYTAWPDHGRPESATPIIRMIEMFRehrkRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTi
 ..|    .    .|...|.|. . ..|..  .    .  | .   .|.   .. .|.. .     .. |  .||  |  |  .. ||. .  ...... 
gltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaets.

pDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQSLTN
 ... . ......||||  ...   .. ||  .|| |... | .
.gsvkledvlkalrkqralaitsalelafvdagivllaievldq
0046846 (Phosphotyrosine protein) phosphatases II 85-299 7.9e-43 141.5 In-house 6-173 (176) alignment 
Range on Protein: 85-299
Range on HMM: 6-173/176.0
IEGVEGSDYINANYIQGPdgnvEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMygaiqvttdheenvsndfiirqlt
.   ...||||||.| |.     .|| |||||.|. ||..|.. ..|..|.. . |||... ||  |||.. .  .                        
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

aecqgekqvirQFHYTAWPDHGRPESaTPIIRMIEMFREHRKRHdIPFAIHCSAGCGRTGTIIAIDfartmLIKKtiPDKLDVFSIVQQMRKQRP-AMVQ
           |.... ||||| |.. . .....|. ||..|..  | ..|||||.|||||..|..     |...     |.|. .....|.|||  .||
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay.....llel..ekglsveealalvreqRplgavq

ALDQYVFVYMAIVELV
  .|| |.|... .| 
tpeQyrflyefellll
0051429 (Phosphotyrosine protein) phosphatases II 89-299 3.3e-47 156.7 In-house 2-225 (272) alignment 
Range on Protein: 89-299
Range on HMM: 2-225/272.0
EGSDYINANYIQGPdgnVE------YIAAQGPLPHTVNDFWRMiWYHQIEIVIMACREVEMAKPKCQCYWP-----------QVGESAMYGAIQVTTDHE
. |.||||... |.           .....||||.|..||||. . ..|  ... ..|.|... || .|||            . ..  |||. ||. .|
plsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

EnVSNDFIIRQLTAE---CQGEKQVIRQFHYTAWPDHGRPESAtpIIRMIEMFREhrkrhDIPFAIHCSAGCGRTGTIIAIDFARtmlIKKTIPDKLD--
| . .|.|.| |...     ||   ....|||.||||| |..|  .....|....     . |. .|||||..||||..|..         .  . .|  
e.llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddY

------VFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
      .. .|...|.|||..||  .||.|.|.|..||.
lltnlyleeaveelraqrpgavqteeqylflyeallell
0043147 (Phosphotyrosine protein) phosphatases II 89-292 1.3e-42 140.7 In-house 3-154 (172) alignment 
Range on Protein: 89-292
Range on HMM: 3-154/172.0
EGSDYINANYIQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREvemakpkcqcywpqvgesamygaiqvttdheenvsndfiirqlTAECQ
||||||||.|. ..    ..|| ||||..|..|||||.. ..| ........                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GEKQVIRQFHYTAWPDHGRPeSATPIIRMIEMFRE-HRKRHDIPFAIHCSAGCGRTGTIIAIDFARtmlikktipDKLDVFSIVQQMRKQRPAMVQALDQ
.... . |..|. ||||| | ..  .....|  .| . .. . | ..|||||.|||||..|..  .          .|... .|...|..|| .||  .|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YVFVY
| |.|
yrfly
0036282 (Phosphotyrosine protein) phosphatases II 90-292 6.5e-42 138.5 In-house 1-163 (174) alignment 
Range on Protein: 90-292
Range on HMM: 1-163/174.0
GSDYINANYIQGPDGNVEYIAAQGPLPhtvndFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQvgesamygaiqvttdheenvsndfiirqltaECQG
|||||||... .   . ..|| ||||.     ||.|.. ..|..|.| ..|.|. . ||  |||                                  . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKQVIRQFHYTAWPDHGRPESATpIIRMIEMFREHRKR-HDIPFAIHCSAGCGRTGTIIAIDFARTMLIkktiPDKLDVFSIVQQMRKQRPAMVQALDQY
... . |..|. ||||| |.... ......  .|.... .. | ..|||||.|||||..|..   ..|.    ..  |....|...|.||| |||  .||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQy

VFVY
 |.|
rfly
0051082 (Phosphotyrosine protein) phosphatases II 90-296 1.9e-35 117.0 In-house 2-150 (151) alignment 
Range on Protein: 90-296
Range on HMM: 2-150/151.0
GSDYINANYIQGPdgnveYIAAQGPLPhtvnDFWRMIWYHQIEIVIMACREVEMAkpKCQCYWPQVGesamygaiqvttdheenvsndfiirqltaecqg
 |||||..|. |      ... .|||.    ||..... ..|  ... . |.|..  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekQVIRQFHYTAWPDHGRPESATPIIRMIEMFREhrkRHDIPFAIHCSAGCGRTGTIIAIDFARTMlikktipdkLDVFSIVQQMRKQRPAMVQALDQYV
    ....... |||.| |.|   .....|....     . |...|||||.|||||..|..    .         ..........|..|| .||  .|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqqfl

FVYMAIV
|...|. 
fqlfall
0049260 (Phosphotyrosine protein) phosphatases II 99-292 1e-39 131.0 In-house 2-143 (152) alignment 
Range on Protein: 99-292
Range on HMM: 2-143/152.0
IQGPDGNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWpqvgesamygaiqvttdheenvsndfiirqltaecqgekqvirQFH
|.|   . |.||.|||.|.|..|||||.. ..| ...| ....|..|.||  |.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

YTAWPDHGRPESATPIIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARtmlikktipDKLDVFSIVQQMRKQRPAMVQALDQYVFVY
.. ||||| |...  .. .... ...... . | ..|||||.|||||..|..  .          ..... .|...|..|| .|.  .|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 104-293 4.9e-20 66.5 In-house 3-198 (199) alignment 
Range on Protein: 104-293
Range on HMM: 3-198/199.0
GNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGE-SAMYGAIQVTTDHEEnVSNDFIIRQLT----AECQGEKQVIRQFH
|.  |||.| || .|. |||.|.|      ..|   .    .     ||| .   .. ||.. |||     .  |. |  |     . .    . | .. 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyq

YTAWPDHGRPESATP---IIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFA-RTMLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYM
.|.| ..  |. |     ..   |. . . . .| |  .||| | | || ..|.|   |.    ||    .|.| . ...|. |  .. .|..| |.| 
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt..svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 104-293 5.3e-20 66.4 In-house 2-197 (198) alignment 
Range on Protein: 104-293
Range on HMM: 2-197/198.0
GNVEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGE-SAMYGAIQVTTDHEEnVSNDFIIRQLT----AECQGEKQVIRQFH
|.  |||.| || .|. |||.|.|      ..|   .    .     ||| .   .. ||.. |||     .  |. |  |     . .    . | .. 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyq

YTAWPDHGRPESATP---IIRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFA-RTMLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYM
.|.| ..  |. |     ..   |. . . . .| |  .||| | | || ..|.|   |.    ||    .|.| . ...|. |  .. .|..| |.| 
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt..svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 108-197 2.4e-10 34.4 In-house 238-323 (440) alignment 
Range on Protein: 108-197
Range on HMM: 238-323/440.0
YIAAQGPLPHTVNDFWRMIWYHQIEIVIMACReveMAKPKCQCYWPQVGESAMYGAIQVTTDHEENVsNDFIIRQLTAECQGEKQVIRQF
.||.| ||  || ||||..  ..|  .||  .   .    |  |||    |  .| . |     ||. |   .| |    . | . ||||
fiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrsvtfgpftvghkgsenm.nrvkvrtlelkykeevheirqf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 110-296 1.6e-22 74.3 In-house 93-285 (302) alignment 
Range on Protein: 110-296
Range on HMM: 93-285/302.0
AAQ--GPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWP-QVGESAMYGAIQVTTDHEENVSNDFIIRQ----LTAECQG------EKQVIRQ
. .   |   |.. .| .|  ... ||.  |  ||  . ||  |.  .||.   .|   |.|   ..  ..|  ..     | | .        |. .  
skkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdi

FHYTAWPDHGRPESATPIIRMIEmFREHRKRHdipFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDkldVFSIVQQMRKQRPAMVQALDQYVFVYMAIV
....|||||| |. | . . ..  | |  |.      .||||| |||||..|| .   .  || . |   . |||. .|. |   ||  .| ... . . 
lafsawpdhGapkeaytaldilk.fcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtd...llsivlpvrqcryGavqdeqqliylllcvt
subfamily_hpo-7_pd Subfamily hpo-7 115-302 9.9e-18 59.0 In-house 43-230 (263) alignment 
Range on Protein: 115-302
Range on HMM: 43-230/263.0
LPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDheeNVSNDFIIR--QLTAEC--QGEKQVIRQFHYTAWPDHGRPE
|  |.. |...|   . | |.| |   | .. ||. |.|    |  ..  ..|.|    .| .| ...  .|.     . . . .... |. |...  ||
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvctt...kvqsdvllktlellstlgeKkkthtvkhysykgWiekndpe

SATPIIRMIEMFREHRKrhdipFAIHCSAGCGRTGTIIAIDFART-M--LIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQS
 |  |...... |. ..       .|||.| ||.     ....   |   ...|   .||  |.....|..|.. ..   |  |  . ....| ..
lareilnilkvarnsks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 118-299 2.2e-20 67.8 In-house 40-221 (255) alignment 
Range on Protein: 118-299
Range on HMM: 40-221/255.0
TVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDHeenVSNDFIIRQL--TAECQ--GEKQVIRQFHYTAWPDHGRPESAT
||. |...|   . | |.| |   | .. ||. |.|    |  ..  ..||| .    |.| ..| |  |..     . . .. ..|. |...  || | 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PIIRMIEMFREHRkrhdiPFAIHCSAGCGRTGTIIAIDFART-M--LIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
 |  .. . |. .     .  .|||.| ||. . . ....   |   ...|   .||  |.....|..|.. ..   |  |  . ...||
eilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 118-298 8.3e-16 51.5 In-house 130-308 (346) alignment 
Range on Protein: 118-298
Range on HMM: 130-308/346.0
TVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQVGESAMYGAIQVtTDHEENVSNDFIIRQLT--AECQGEkQVIRQ-FHYTAWPDHGRPESATPI
 |.||| ||.  ||..| .   .  . .     .  . |     | . .  ..  .|| |     .    | . .  || |  |.. |    .|  . ||
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfi.nnrradvsgdpkeytievlpegnsd.svicqvhhhapwkhlqqppktlpi

IRMIEMFREHRKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPdklDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
|.||  |   .. ...   .    ||||. ..|   .|   |     |   ... |......|||  |... ||  .|  ... 
ikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiep...niceimknikqqrpggvesfaqyasiyaivfdy
0048076 (Phosphotyrosine protein) phosphatases II 160-298 1.2e-26 88.5 In-house 12-142 (145) alignment 
Range on Protein: 160-298
Range on HMM: 12-142/145.0
MYGAIQVTTDHEENVSNDF-IIRQLTAECQGEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHdIPFAIHCSAGCGRTGTIIAIDFARTmlik
 .| . .. | |.  ....  .  || |...... . |..|. ||||| |...  .....|. .|..|..  | ..|||||.|||||..|..  ..    
ylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

ktipDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
     ...........|.||| .|.  .|. |.|... ||
....lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_PTEN_pd Subfamily PTEN 175-287 1e-06 23.9 In-house 59-168 (184) alignment 
Range on Protein: 175-287
Range on HMM: 59-168/184.0
SNDFIIRQLTAECQGEKQ-VIRQFHYTAWPDHGRPES--ATPIIRMIEMFREHRKRHDIpfAIHCSAGCGRTGTIIAIDFARTMLIKKtIPDKLDVFsiv
.... |  |..| . ... .  . . .   ||  |.    ..|.. ||.. |. |.. .  ..|| || ||||..|.  .  ..|..|   . |..|   
kdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvv..vvHCkaGkGRtGvlivayllkslllek.aeealelf...

QQMRKQRPAMVQALDQ
...| .    |.   |
aeaRtknkkgvtiPsq
0048179 (Phosphotyrosine protein) phosphatases II 176-293 6e-24 79.8 In-house 48-139 (144) alignment 
Range on Protein: 176-293
Range on HMM: 48-139/144.0
NdfiirqltaecqgekqvIRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHdIPFAIHCSAGCGRTGTIIAIDFARtmlikktiPDKLDVFSIVQQMR
.                 . |.... ||||| |.... .....|...|.....  | ..|||||.|||||..|..  .          .|.........|
e.................giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

KQRPAMVQALDQYVFVYM
..|| .|.  .|. |...
srrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 188-298 1.6e-18 61.6 In-house 211-343 (350) alignment 
Range on Protein: 188-298
Range on HMM: 211-343/350.0
QGEKQVIRQFHYTAWPDH---GRPESATPIIR----MIEM--FREHRKR-HDIPFAIHCSAGCGRTGTIIAIDFART-MLIKK---------TIPDKL-D
  .  |. |...  |.|     .|||  ...     .|.    ..| .  .  |  .|||||.|||||....|.    ..| .           . |. |
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

-VFSIVQQMRKQRPAMVQALDQYVFVYMAIVEL
 .. ||...||||  ||| |||..|.| |.  .
lisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-299 1.1e-24 81.6 In-house 87-194 (440) alignment 
Range on Protein: 190-299
Range on HMM: 87-194/440.0
EKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHR-KRHDIPFAIHCSAGCGRTGTIIAIDfarTMLIKKTIPDKLDVFSIVQQMRKQRPAMVQALDQY
| ....|.|| .|||.| |. | |...||.   | . |  . |. .|||||.|||| |||.|   ..| .    |..|.||... ||..|| |||. .||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavd...silreakrsdqidifsfinsmrnnrpqmvqtpeqy

VFVYMAIVELV
.||. |..| .
afvheavlegl
PTPc_DSPc_SM00012 194-296 2.2e-33 109.9 In-house 2-104 (105) alignment 
Range on Protein: 194-296
Range on HMM: 2-104/105.0
IRQFHYTAWPDHGRPESATPIIRMIEMFREHRKRHD--IPFAIHCSAGCGRTGTIIAIDFARTMLIKKTipDKLDVFSIVQQMRKQRPAMVQALDQYVFV
....|||.||||| ||....|..... ...... ..   |  .|||||.|||||..|.| .  .| |.|  ...|.| ||...||||| ||| ..||.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

YMAIV
|.|. 
yrall
0038934 (Phosphotyrosine protein) phosphatases II 196-287 3.7e-08 28.7 In-house 81-165 (194) alignment 
Range on Protein: 196-287
Range on HMM: 81-165/194.0
QFHYTAWPDHGRPESATPIIRMIEMFREHRKR-HDIPFAIHCSAGCGRTGTIIAIdfartMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQ
...   .||.| . |   . | ...  |. ..  .   |.|| || |||||..|       ||..    ....   .. .|  || ...  |.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.....YLiyr...lgmsaeeAialfrekRpgaipnqdy
PTEN_1 196-275 2.6e-06 22.4 In-house 96-171 (196) alignment 
Range on Protein: 196-275
Range on HMM: 96-171/196.0
QFHYTAWPDHGRPESAtPIIRMIEMFREHRKR--HDIPFAIHCSAGCGRTGTIIAidfarTMLIKKTIPDKLDVFSIVQQMR
...   ..||| |  .  ...... | | ...  .    ..|| || ||.||..|       |..|   .  . ...|...|
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.....ayLmykgkltadeAlelvrekR
subfamily_PTPDC1_pd Subfamily PTPDC1 197-290 7.6e-09 30.3 In-house 85-167 (182) alignment 
Range on Protein: 197-290
Range on HMM: 85-167/182.0
FHYTAWPDHGRPeSATPIIRMIEMFREHRKRHdiPFAIHCSAGCGRTGTIIAIdfartMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVF
..  .|.|.| . | . |. .. .     ..     |.|| || |||| .||      .|. .   ..|.    .. .|..||  .|. .|  .
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliac.....ylvya...krltaekaiklvrskrpksiqtreqvel
subfamily_DSP23_pd Subfamily DSP23 199-291 8e-07 23.8 In-house 56-138 (148) alignment 
Range on Protein: 199-291
Range on HMM: 56-138/148.0
YTAWPDHgRPESATPIIRMIEMFREHRKRHDIpFAIHCSAGCGRTGTIIAIdfartMLIKKtipDKLDVFSIVQQMRKQRPAMVQALDQYVFV
    .|.  | .   . .....  |  .. .   ..||  | |||||..|       |.|.    ||     . ..|..||  |....|   |
rlriddy.hppaleqvvefvrvveeaeeknea.vsvhcllgrgrtgtmlac.....ylvke...rklaaaeaiaevrrlrpgsvetveqeklv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 217-299 4.4e-15 50.3 In-house 217-295 (297) alignment 
Range on Protein: 217-299
Range on HMM: 217-295/297.0
MIEMFREHRKRhDIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTIPDkldVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
 .| .| .  | ...  .||||| ||.| ..  |   ..| || |||   | .|....|.||. .||.|.|. ..| |... .
qleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripd...vaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 225-297 1.4e-13 45.2 In-house 243-313 (319) alignment 
Range on Protein: 225-297
Range on HMM: 243-313/319.0
RKRHDIPFAIHCSAGCGRTGTIIAIDFARTMLikKTIPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
.. .  | ..||| | ||||..|| |.|   |  ..    .|.  .|...|..|   |.. .|| |.|  . |
tresqGPlvvhcsdGvGrtGlviasdiairsl..eeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 229-297 2.8e-13 43.9 In-house 265-342 (349) alignment 
Range on Protein: 229-297
Range on HMM: 265-342/349.0
DIPFAIHCSAGCGRTGTIIAIDFARTMLIKKTI-PDKLD--------VFSIVQQMRKQRPAMVQALDQYVFVYMAIVE
  .. .||||||||||... .|.   .|.  .    |..        .. || ..|||| .||| | |....| |...
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 234-299 1.7e-14 47.9 In-house 3-65 (69) alignment 
Range on Protein: 234-299
Range on HMM: 3-65/69.0
IHCSAGCGRTGTIIAIDFArTMLIKKtiPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
.|||.| |||||.|||       ||      .|.|  || ||| || ||    .|.|.. |.|| .
vhcssgtgrtgtfiaimve.mariks..eklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 234-299 3.9e-14 46.7 In-house 2-64 (69) alignment 
Range on Protein: 234-299
Range on HMM: 2-64/69.0
IHCSAGCGRTGTIIAIDFArTMLIKKtiPDKLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELV
.|||.| ||||| |||       ||      .|.|  || ||| || ||   ..|.|.. |.|| .
vhcssGtGrtGtfiaimve.mariks..eklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_ptpA1_pd Subfamily ptpA1 264-301 7.7e-08 26.5 In-house 363-400 (418) alignment 
Range on Protein: 264-301
Range on HMM: 363-400/418.0
KLDVFSIVQQMRKQRPAMVQALDQYVFVYMAIVELVQQ
 ...|||| ..|.||| ||| |.||.|.| .|.. . .
dfnlfsivlklreqrpgmvqqleqylfcyktildeiyh