Gene PTPN6-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP053_AA protein Get Run
AqueP053_AA_216-506 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 6-79 6.7e-19 58.4 Pfam-A 3-77 (77) alignment 
Range on Protein: 6-79
Range on HMM: 3-77/77.0
FHHVSRVGAEELLLSKGTVGSFLTRRSESDPKNFTLSVRQRDGVTHVRIQHDGEF-YDLYGGEEFASLPELLHFY
. ..||  ||.|||.... |.|| | ||| | ..||||.... |.|.|||.. .  | . ..|.| ||.||...|
hgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
SH2 SH2 domain 110-185 1.6e-21 66.8 Pfam-A 1-77 (77) alignment 
Range on Protein: 110-185
Range on HMM: 1-77/77.0
WYHADMSGKDAELLLLAKGQDGSYIVRTSMHSPGNFVLSTRVGDEVSHVKINHKDGS-FQIDNGPAFRSLNSLIDYY
||| ..|...|| |||....||...|| | ..||...|| .  ..| |..|.... . . | ..  |.||. |...|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
0050432 (Phosphotyrosine protein) phosphatases II 203-508 3.8e-97 320.6 In-house 13-302 (308) alignment 
Range on Protein: 203-508
Range on HMM: 13-302/308.0
AYCTTSFLPKHIEQRVEELRQPNDELFGKTGFEEEYQQLQHEGTqhLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLaepdSSGNTYINANYVNGEVPGS
... ||.|.......|..| .  .........|||...|..  .  |.... | .| |. |||.|.|||.||.||.|    ..|..||||.||.| . ..
lfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgysskl

GNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSK--GETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRgHYVVQYQFK
 . .|||||.||.|..||| |||......|||.|...|.|..|||.|||..  |... ||...| ...| .   |. |.|........   ..| .....
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhyt

VWPDHGVPQDPSHMLDLMDDVNRKAleiqqRGehfGPMIVHCSAGVGRTGTYIVVDIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYA
 |||||||..|...||... |...      .|   ||..||||||||||||.|..|..  ..|..   ...||.. |..||..| |||||..||.|||.|
nWpdhgvPpspeilldflelvrksl.....pg...gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyra

IKAYIERR
.  |....
lleylklk
subfamily_PTPN6_pd Subfamily PTPN6 206-513 3.1e-144 474.6 In-house 1-305 (306) alignment 
Range on Protein: 206-513
Range on HMM: 1-305/306.0
TTSFLPKHIEQRVEELRQpNDELFGKTGFEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSGNTYINANYVNGEVPGSGNY
.||.|.|.|||||.||.. ..| ..|.|||||...||.| ...|..|||. || |..|||.|||||||||||.|.||. .|..||||||...||.|| ..
atsllakeieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdks

YIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDH
||||||||. |..|||.|||||.|..|||.|.|.||||.|||||||.. |.. ||.|.| |..| . . |..|.|......||.. ..|.||.||.||||
yiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdh

GVPQDPSHMLDLMDDVNRKALEIQQRgeHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
|||.||...||...|||||. |....  . ||..||||||.|||||.||.||..|..|.......||.| .|...|..|||.||||.||.|.|.|||.||
gvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

ERRQSLNE
|....|.|
etkkklee
subfamily_PTPRA_pd Subfamily PTPRA 209-504 3e-73 241.6 In-house 11-294 (330) alignment 
Range on Protein: 209-504
Range on HMM: 11-294/330.0
FLPKHIEQRVEELRQPNDElfGKTGFEEEYQQLQHEGTQHlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSGNT-YINANYVNGEVpgSGNYYI
. |  .|.  ||.|.   .      | ||.. |     |   | . | |  |..|||. ||||.|..||.|.. .   .. |||| ...|      ...|
yfplpvekleeeirirsad..dnklfreefnalPagpiqa..tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk..ekdkfi

ATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTlYGNIQVINIDEIQGRLYVFRKLHIEHVSKK---GRGHYVVQYQFKVWPD
|.|| .  |..||| |.|. .|  |||.|.  || ..|||.|||..|  | ||||.|   ||     |  ||. .......    .   | |. |. |||
aaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPd

HGVPQDPSHMLDLMDDVNRKAleiQQrgeHFGPMIVHCSAGVGRTGTYIVVDIITKMMeynKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY
 ||| .|  ||.|.  |...    ||   . ||..||||||||||||.||.| . ...   | |  .|| . |. ||  |. ||||. || |.| ... |
vGvPfepiGmlkllkkvkkln...qq...sagpivvhcsaGvGrtGtfivldavlerv...kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 213-508 1.7e-89 295.0 In-house 6-283 (318) alignment 
Range on Protein: 213-508
Range on HMM: 6-283/318.0
HIEQRVEELRQpndelFGKTGFEEEYQQLQHEGTQhlYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVNGEVpgSGNYYIATQG
..|..|..||.      |.. ..|||..|...  .   |. .. .| |..|||. |||..||||| | .  .. |  ||||||..|    . . |||.|.
dleshvrrlre.....sGelllseeyerlsrseet..vtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr..rkkayiaaqa

CLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGeTTLYGNIQVINIDEIQGRLYVFRKLHIEHvSKKGRGHYVVQYQFKVWPDHGVPQDP
 || ||.||| |||. .|..|||.|.| ||||.|..||||||| .. ||...|   .|..   || |...... ...     | ||..  |||.|||...
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesg

SHMLDLMDDVNRKaleiqQRGEHFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
...|||. .|..      |. .  ||..|||||||||||..|.|||   ..|  | |  .|| . |..||..|  |||||||| |.| ... ...  
aslldlvrqvska.....qqksgagpivvhCsaGvGrtGvfiavdi...llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
0051299 (Phosphotyrosine protein) phosphatases II 216-505 4.1e-92 303.9 In-house 12-286 (288) alignment 
Range on Protein: 216-505
Range on HMM: 12-286/288.0
QRVEELRqpndeLFGKTGFEEEYQQLQHEGTQhlYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNGevPGSGNYYIATQGCLP
..|..|.     . |.||..||...|..  ..  .|.. | .| |..|||...|||.||.||.|  .|. .|..||||.|..|  . ... .|||||.||
klvlkll.....angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg..ynlkrkfIatqgPlp

GTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSkGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVS---KKGRGHYVVQYQFKVWPDHGVPQDP
.|..||| |||......|||.|...|.|..|||.|||. |... ||.|.| ...| .   |. |.|......   ..|  ..| ..... |||||||..|
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

SHMLDLMDDVNRKALeiqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
...||.. .|...         . ||..||||||||||||.|..|..  ..|..   ...|| . |..||..| |||||..||||.|.|.  |.
ellldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 216-503 2e-53 176.4 In-house 9-277 (439) alignment 
Range on Protein: 216-503
Range on HMM: 9-277/439.0
QRVEELRQPNDELFgktgfEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLA-EPDSSGNTYINANYVNGEVpgSGNYYIATQGCLP
. ||.| . ..|.|     .|......    ..      | .  .. |||.|.. .||||||.|   |      ||||||..|      . ||||||   
ehvekldknkqeif.....keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy..ddklyiatqgpkk

GTINDFWSMVWQEDSKIIVMITNEIERGKnkcarYWPSKGETtLYGNIQVINIDEIQGRLYVFRKLHIEHVSKK-GRGHYVVQYQFKVWPDHGVPQDPSH
 | .||| .|... .  |||.|| .|  |     ||||..|.  ||.| |    .|.   || | ...     .  . . |.|...  |||. || . ||
ettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

MLDLMDDVNRKaleiqQRGEHFGPMIVHCSAGVGRTGTYIVVDIItkmMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKA
.||..  .|       .  | .||..|||||||||||| | .||    .|  | | ..|..| |..||..|  |||.  || |.| |.  
vldflrainsa.....ndkeeygpvvvhcsagvGrtGtiialdia...leqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 217-507 6.2e-80 263.6 In-house 13-285 (319) alignment 
Range on Protein: 217-507
Range on HMM: 13-285/319.0
RVEELRQpndelFGKTGFEEEYQQLQHEGTQhlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVNGEvpGSGNYYIATQGCLPG
|...|..      |.|..|.|...|.. ...   | ..| |. |..|||..|||..|.|||||.| ... | .||||....|      . .||||. |  
rlkalas.....tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlen

TINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKgETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHML
||.||| |||.|.| |.||.|.  |..| |. .|||.. . . ||.. |   .| .   |. |||.... | .     |...|.. ||||.||..   .|
tiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

DLMDDVNRkAleiqQRGEHFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
||. .... .    ..... ||..||||||||||||.||.|.   |.|  | |  .||   |..||  |  |||...||.|.|.|. ...| 
dllkrirk.s....rektqsgPivvhCsaGvGRtGtfivlda...mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0039614 (Phosphotyrosine protein) phosphatases II 218-507 6.1e-85 280.5 In-house 18-291 (297) alignment 
Range on Protein: 218-507
Range on HMM: 18-291/297.0
VEELRQPNDELFGKTGFEEEYQQLQHEGTQhlytRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS--SGNTYINANYVngEVPGS-GNYYIATQGCLP
|..| .  . ...||....|...|.         ...| .| |. |||.|.|||.||.||.|  .|.   ...||||.||  ...   .. .|||||.||
vldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlp

GTINDFWSMVWQEDSKIIVMITNEIERGKnKCARYWPSKGEttLYGNIQVINIDEIQGRLYVFRKLHIEHvskKGRGHYVVQYQFKVWPDHGVPQDPSHM
.|..||| |||......|||.|...|.|. |||.|||..|.   ||...| ......   |. |.|....   .|  ..| ..|.  |||||||......
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslell

LDLMDDVNRKALEIqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
|.... |..   |     .  ||..||||||||||||.|. ...  ..|..   ...||.  |..|| .|.|.|||..||||||.|.. .. |
leflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 225-506 4.4e-76 251.0 In-house 20-291 (298) alignment 
Range on Protein: 225-506
Range on HMM: 20-291/298.0
NDELFGKTGFEEEYQQLQHEGTQ-HLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVNGEVPGSgnYYIATQGCLPGTINDFWS
 .. .. ||...|.|.|..   . .  . . | || |..|||. .|...|..|||| .  .    .|||| ....    .   .||||. |. |..||| 
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWr

MVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTlYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVN
||..||.. |||.||  | .| |. .|||..|..| ||.|.|    . .   .. |||.... ... . . |.| .| .|||.|||.  . .|||...|.
mvteedigtiVmltnleeldktkyhkywPdegket.ygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvr

RkalEIQQRGEHfgPMIVHCSAGVGRTGTYIVVDiitKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
.     || |..  |.||.|||||||.||.|..|    ..|  | |  .||   |..||..| |.||||.|| |.|.|.  ...
a...sqqqagnk..pvivqCsaGvgRsGtfiaid...svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 225-507 9.6e-64 210.0 In-house 13-285 (290) alignment 
Range on Protein: 225-507
Range on HMM: 13-285/290.0
NDELFGKTGFEEEYQQLQHegTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPD---SSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFW
|..  |..||......|.   ... .| . .  . |...|||.||.. |  |..| .        | |||| |..|      . |||||| .. |. |||
nghakgnegfrnqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk..ekkqyiatqgpvsntlvdFW

SMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTlYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDV
...|||.. ||||.||.|| ||.||  |||... .. ||....  ..| .   |. |||.... ...|. . |.|||.. |...|  ..|. .| ..  .
kliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

NRKaleiqQRGEHFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
...     || .  ....||||..|||.........    ..  | |  |||   .. .|  . |.|||..||..... .  |...
ykt.....qrkrgntsivvHCSdtvgrsavfcaaat...tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 225-508 2.3e-58 192.4 In-house 13-281 (287) alignment 
Range on Protein: 225-508
Range on HMM: 13-281/287.0
NDELFGKTGFEEEYQQLQH-EGTQHLYTRKEAGKplNRQKNRFKNILPFDHTRVVLAepdSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSM
...  |..||.. .. |.. . ...  | . | .  |..|||...||. |  ||.|       . |||| ...|    . . .|.... .  |. .|| .
kghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk...gehpdyinavfidgyk..ekkafiiaesPmfntarnfWkl

VWQEDSKIIVMITNEIERGKNKCARYWPSKGEtTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNR
....  ..|||...| |  ...| .|||..   ...|. ..  ..| .   |. |||.... .|.|  . |.|||.  |...|  ..|  .| .... ..
iddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk

KaleiqQRGEHFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
.     || .  ....||||..|||..... ...    ..  | |  |||   ..  |  . |.||| .||.|.. .. .|..  
t.....qrkrgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
0036941 (Phosphotyrosine protein) phosphatases II 226-508 1e-90 299.4 In-house 7-280 (297) alignment 
Range on Protein: 226-508
Range on HMM: 7-280/297.0
DELFGKTGFEEEYQQLQHEgtQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLaepDSSGNTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVW
..|........|...|..   ..|.... | .| |..|||.|.|||.|||||.|   |..|. ||||.||  .... .. .|||||.||.|..||| |||
ekllflalllkefeellpl..lllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvw

QEDSKIIVMITNEIERGKNKCARYWPSK-GETTLYGNIQVINIDEIQ--GRLYVFRKLHIEHVsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVN
......|||.|...|.|..|||.|||.. ||.  ||...| .... .     |. |.|..... ..|  ..| ..... |||||||..|...||... |.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvr

RKAleiQQRGEHfGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
..    ..  .. ||..|||||||||.||.|..|..  ..| .. |...|.   |..||..| |.|||..||||||.|.  .. ..
kvl...kllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 226-505 1.8e-87 288.5 In-house 6-272 (273) alignment 
Range on Protein: 226-505
Range on HMM: 6-272/273.0
DELFGKTGFEEEYQQLQHEGTqhLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLaepDSSGNTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVW
..|.|.|...||...|.   .  |.|.. | .| |..|||.|.|||.||.||.|   ...|. ||||.||  ... ... .||||| ||.|..||| |||
ekllgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvw

QEDSKIIVMITNEIERGKNKCARYWPSKGE--TTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGrGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNR
......|||.|...|.|..|||.|||..|.  .. ||...| ...| .   |. |.| ..... .   ..| ..... |||||||......|.....|..
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrk

KALEIQQRgehfGPMIVHCSAGVGRTGTYIVVDIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
.  .. .     ||..||||||||||||.|..|..  ..|..   ...||   |..|| .| |||||..||||||.|.  |.
alealpsn....gpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 226-507 4.5e-70 230.7 In-house 9-282 (288) alignment 
Range on Protein: 226-507
Range on HMM: 9-282/288.0
DELFGKTGFEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAepdSSGNTYINANYVNGEVPGSGNyYIATQGCLPGTINDFWSMVW
  | |||........|...  ..   |  |   |. .|||...|||.||.||.|    .| . |||| .|.. .||. . .||||. |..|.||||.||.
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvy

QEDSKIIVMITNEIERGKNKCARYWPS-KGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRK
.. |..|||.... |.||.|..||||. ||||. .|...|   .. .   .| |.|..|. ... . . |.  |.. ||..|||. |...|...| |. .
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesa

ALEIQQRGEHfgPMIVHCSAGVGRTGTYIVVdiITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
  . |.. .   |..|||||||||||.. .|  .. . | .| .  .|.   |. ||. |  |||...|..|.| |.  ...|
yeavqrkskt..PlvvhCsaGvgRtgvfalv..yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPRN_pd Subfamily PTPRN 226-502 1.3e-54 179.9 In-house 23-289 (297) alignment 
Range on Protein: 226-502
Range on HMM: 23-289/297.0
DELFGKTGFEEEYQQLQHEGTQHlYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPD-SSGNTYINANYVNGEVPGSGnYYIATQGCLPGTINDFWSMV
| |  |. .|.|.. | .  ..   |.. | .. | .||| |..||.||.|| | |   .. . ||||  .  . | .   |||||| |. |. ||| ||
dhlknkdrlekewealcayeaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastvadfwqmv

WQEDSKIIVMITNEIERGKNKCARYWPSKGETtLYGNIQVINID-EIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNR
|.. . .||..|.  | | ..|.|||| .|.  .|.  .|  .   |    |. | ...  . .. .   | |. |  ||..|||  .  .|..   ||.
weqGvvvivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnk

KaleiqQRGeHFGPMIVHCSAGVGRTGTYIVVDIITKMMeyNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIK
       ||    |..||||.|.||||.||..|.. . .  .|   |||.  ... ||  |.|.|.|.||..| . |. 
s.....yrG.rscpivvhcsdGaGrtGvyilidlvlnrl..lkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 228-507 3.7e-71 234.8 In-house 18-285 (305) alignment 
Range on Protein: 228-507
Range on HMM: 18-285/305.0
LFGKTGFEEEYQQLQHEGTQHLYTRKEAgkplNRQKNRFKNILPFDHTRVVLAEPDSSG-NTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQ
   ..|.|..|..|..|...   ..|||    |..|||.|.| ..|. |. |.| .| . . ||||.||.|    . . ||..|| |. |..||| ....
vysdkgleaqykslyeeeesidvgkkea....nkaknrlkeitlldddriiltekeslddsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrlive

EDSKIIVMITNEIERGKNKCARYWPSK-GETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKa
|  . |||.|. .| ||.|| .||| . .|.. .|...|.  .| .   |. |||.|   ...  .. |.|||.  |||||||| .. .|.|...|... 
ekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd.

leiqQRGEHFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
    |. ..  |..|||||||||||..|.|||   ..|  | | ..|| . .. ||..| .|||| ||| ||. |.. .|. 
....qkkdkgvpllVhCsagvgRtGvfiavdi...alerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
0043336 (Phosphotyrosine protein) phosphatases II 229-505 2.5e-83 275.1 In-house 17-277 (278) alignment 
Range on Protein: 229-505
Range on HMM: 17-277/278.0
FGKTGFEEEYQQLQHEGTqhlYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSS-GNTYINANYVNGevPGSGNYYIATQGCLPGTINDFWSMVWQE
 .||....|...|..  .   .|.. | .| |..|||.|.|||.||.||.|   ..  ...||||.||.|  .  .. .|||||.||.|..||| |||..
nlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg..ynvprkfiatqgPlpetvedFwrmvwel

DSKIIVMITNEIERGKNKCARYWPskGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRgHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALe
....|||.|.. |.|..|||.|||  |... ||...| ...|..   |. |.|....  ..   ..|..|... ||||||| ..|..||.. .|...   
gvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.

iqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
        ||..||||||||||||.|.....  ..|...   ..|..  |..||..| |.|||..||||||.|.. |.
.....dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN12_pd Subfamily PTPN12 229-508 1.2e-81 268.8 In-house 5-280 (290) alignment 
Range on Protein: 229-508
Range on HMM: 5-280/290.0
FGKTGFEEEYQQLQHEGT----QHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSG-NTYINANYVNGevPGSGNYYIATQGCLPGTINDFWSM
 |.  |..|.|.|... .    .. |..... |. |..|||.|.|||.|..||.| . ...  . |||||...|  . .   |||.|| || |..||| |
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..vegkleyiaaqgPLpktlddfWrm

VWQEDSKIIVMITNEIERGKNKCARYWPSKGETTL-YGNIQVINIDEIQGR-LYVFRKLHIEHVskkGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDV
.|. . .|.||. .|.| ||.||.||||..||..| .|...| ...| .    .. | |..|.    .  . | |.... |||||||. ....|.|...|
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielv

NRKALeiqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
..         ..  |..|||||||||||| |..|.. .... .| . |.||   |. ||..|. .|||..||...| |.  .....
relqe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPRD_pd Subfamily PTPRD 230-507 4.5e-96 317.7 In-house 21-283 (564) alignment 
Range on Protein: 230-507
Range on HMM: 21-283/564.0
GKTGFEEEYQQLQHEgtqHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLA-EPDSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQED
... |||||......   .  | ..| || |..|||..||...||.||||   .  .|  ||||....|    . . |||||| |. ||.||| |||...
sdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqn

SKIIVMITNEIERGKNKCARYWPSKGeTTLYGNIQVINIDEIQGRLYVFRKLHIeHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAlEi
|..|||.|.  |.||.||..|||.|| |. ||...|   .| .   |..|.. . . .|.   . | |..|  |||||||. . ..|||...|.. . | 
sstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.

qqrgEHFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
    .. ||..||||||||||||.||.|.   |.|  | |  .|. . |..||..|  |||||.|| |...||  ... 
....pdagPivVhCSaGVGRTGtfivida...mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0045450 (Phosphotyrosine protein) phosphatases II 230-506 1.9e-90 299.0 In-house 25-305 (307) alignment 
Range on Protein: 230-506
Range on HMM: 25-305/307.0
GKTGFEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS--SGNTYINANYVNG------EVPGSGNYYIATQGCLPGTINDFW
..||...|...|... ...|.....| .| |. |||.|.|||.|||||.|  .|.  ... ||||.||.       ... ... .|||||.||.|..|||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

SMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDV
 |.|......|||.|...|.|..|||.|||..||.  |||..| ...| .   |. |.|.... ...| ...| ..... |||||||......||... |
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

NRkaleIQQ----RgehfGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
..    ...         ||..||||||||||||.|. ... ...|...  . .|..  |..|| .|.|.||...||||||.|.. .. 
rk....aleelpkg....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0040438 (Phosphotyrosine protein) phosphatases II 230-508 8.5e-89 293.2 In-house 16-279 (317) alignment 
Range on Protein: 230-508
Range on HMM: 16-279/317.0
GKTGFEEEYQQLQHEgtqH-LyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVWQE
..|...||...|..    .   |...| .| |..|||...|||.||.||.|  ...  ...||||.||  ..|  .. .|||||.||.|..||| |||..
dftalleefedllsl...kld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvweq

DSKIIVMITNEIERGKNKCARYWPSkGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAle
....|||.|.. |.|..|||.|||. |||. ||...| ...|..   .. |.|..|.  ...  ..| ..... |||||||..|...||... |...   
gvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreal..

iQqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
 .   .. ||..||||||||||||.|.....  ..|...   ..||.  |..||..|.|.|||..||||||.|.  |. |.
.e...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 230-506 1.4e-81 268.8 In-house 19-280 (288) alignment 
Range on Protein: 230-506
Range on HMM: 19-280/288.0
GKTGFEEEYQQLqhEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQED
..|||.|||..|     ..  . . . .. | .|||..||||.|..|| | . .. .|. ||||.|..||  .. . |||||| |. |.|||| .|....
nrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelvyenk

SKIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIEhvsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEI
.. |||.|. .|.||.|| .|||.... ..||...|. ... .   .| ||| .|   ||.    . |||...|||||||..   .|.|.. |.    . 
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

qqrgehFGPMIVHCSAGVGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
       ||.|||||||||||||.|..| . ...|    |  ||| | |. ||..|  .|||. || |.| ..   ||
......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_PTPRG_pd Subfamily PTPRG 230-509 7.8e-74 243.9 In-house 17-291 (563) alignment 
Range on Protein: 230-509
Range on HMM: 17-291/563.0
GKTGFEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGN-TYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQE
|..||.||...||.| ...  . . . || |..|||  ||...|..|| |.. |.  ..  ||||||..|     .. .||||| |. |..||| |.|..
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq..kskafiatqgplkdtfddFWrmiWeq

DSKIIVMITNEIERGKNKCARYWPSkGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGR-----GHYVVQYQFKVWPDHGVPQDPSHMLDLmddVN
 ..|||||||  |||..|| .|||.  |.  ||..||  |.| .  ||  |.| |... .|        . | ||..  |||||||. .   |     |.
nvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif...vk

RKaleIQQRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQ
..    . . .. ||..|||||||||||||||.| ..| ..    |  ..| | ....| .|  .||||.|| ||. |.   |  ..
ks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq...enavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_PTPN9_pd Subfamily PTPN9 230-511 2.4e-72 238.5 In-house 14-296 (297) alignment 
Range on Protein: 230-511
Range on HMM: 14-296/297.0
GKTGFEEEYQQLQHEGTQHlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQED
|| |  .||.....| ..   | . . ...| .|||....| .|.||||||. .. .   |||||.|.|      . .||||| |. |..||| |||...
gkrGlskeyaeirnepveG..tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvWeqe

SKIIVMITNEIERGKNKCARYWP-SKGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRK-A-
  .|||.|  .|||. ||..||| ...... .|...| |..  . . |..|.|.|..| |...   |. .||  |||.|||.. . .||... | .| | 
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

----LEIQQRGEHFG-PMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSL
    |  ...|.  | |..||||||.|||||.| .||  . .|       .||. .|..||  |. ..||..|| | | |.  |  ....|
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavleyalelkal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 230-501 4.2e-65 215.1 In-house 32-287 (319) alignment 
Range on Protein: 230-501
Range on HMM: 32-287/319.0
GKTGFEEEYQQLQHEGTQhLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQED
 .| .| |.... . |.. | ... |  . |. |||. |||.||...| |   .   .  |||| .|.|    . . |||.|| |. |..||| |.|. .
dltklevefrracklgvn.ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyn

SKIIVMITneiergKNKCARYWPSKGETT-LYGNIQVINIDEIQGrlYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNrkalE
.  ||..|      |.||..||| |.. .   ....|  ..| .   || |.... . .|.     . |. |. |||.|||. || .. |.. |.     
cstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr....h

IQQRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
.... .|  ...|||||||||||.|||.|.. ..|.    |  .||   |. ||  |. .||   || |.| |.
ltskenhranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 230-518 1.9e-59 196.2 In-house 22-293 (315) alignment 
Range on Protein: 230-518
Range on HMM: 22-293/315.0
GKTGFEEEYQQLQheGTQhLYTRKEAGKPLNRQKNRFKNILPFDHTRVVL--AEPDsSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQE
 | ||...|. .   | | |.  . | |  |.||||. ||...|..|| |   | | ..  |.|||...|      . |||.|| .. ...||| .|..|
tkngfkqdyesip..ggq.lhpldvakkienkqknryiniiaydksrvqlpllend.phsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfee

DSKIIVMITNEIERGKNKCARYWPSKgeTTLYGNIQVINIDEIQGRLYVFRKLhieHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMddvnRKALe
|   |||.|| .|. |.|. .||| |    .||.| |  ..| .   |  | |    |  . . . |||...  ||| |||.    ...|.    |..  
digkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnli....rtvk.

iQQRGEHFGPMIVHCSAGVGRTGTYIVVDiitKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI-KAYIERRQSLNEALYVN
 | . .  |...||||||||||||.| .|    ...  . |  |||   .. .|. | .|||. .||.|.| |. ....    |. . ||..
.qhhtnsvgaivvhcsaGvGrtGtfitld...avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 230-514 2.5e-34 113.3 In-house 25-299 (310) alignment 
Range on Protein: 230-514
Range on HMM: 25-299/310.0
GKTGFEEEYQQLQHEGTQHLytRKEAGKpLNRQKNRFKNILPFDHTRVVLAEPDSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDS
|  |.  .|..|. .  . |    || |  . .|||. ...  | .|| |    |  . || ||||. .     . .| .|| |  || ||| |..|| .
gieglvkqyrkldakqdssl..tyeayk.kymhknrysdvvcldtsrvklkidksryedyihanyvktny..lrstficsqgplqhtiidfwrmifqera

KIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRL--------YVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMldlmddV
. |... .  | |. ||  |||| | |  || |.| |. |    .        .|  .. ..    . ..  |   ..  ||| |||..  |       |
esilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht......v

NRKaLEIQQRgehFGPMIVHCSAGVGRTgtYIVVDIITKMMEYnKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSLNEA
 .. |  | |    || .||||||..|.  |.|| .  |.    .   ..|..  .  |...|   .||| || .. .   ..    .   | 
pqr.llaqvr...hgpcvvhcsagkdrl..yvvvalklkidkl.drglkvdaeevktellksraiciqtelqyliidrvriifargetevaek
subfamily_PTPRB_pd Subfamily PTPRB 231-510 5.8e-88 289.7 In-house 24-290 (293) alignment 
Range on Protein: 231-510
Range on HMM: 24-290/293.0
KTGFEEEYQQLQHEGTQHLYtrKEAGKPLNRQKNRFKNILPFDHTRVVL-AEPDSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDS
...| |||..|.. |...    | | .. ||.|||..||||.||.|| | |  |.||. ||||||..|    | . .||||| ||.|..||| |||.. |
dlrfseeyeelkavgkdqav..kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwekks

KIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIEHvskKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNrkalEIQ
.||||.|. .|.|| || .|||.. |..|||.|.|  . | . . .| |.|.||.   . . . | ||.|. |||||||.... .||..  |.    | .
siivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvr....eai

QRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQS
.. .. .|..||||||||||||.| .| ... .| . .   .|. | |. ||..|  .||||.|| |.. .. ........
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedy...vdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 231-508 1.9e-77 255.1 In-house 14-279 (281) alignment 
Range on Protein: 231-508
Range on HMM: 14-279/281.0
KTGFEEEYQQLQHEGTQHlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSGN-TYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDS
..|| |||..|.. |...  | . . .. |..|||..||  .|.|||.... ... |  |||||.|.|    . . |||||| .| ....|| |||... 
naGfieeyeklaaigvdn..tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk..gekeyiatqgPvPaslvafWqmvweqkv

KIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIehVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQ
..|||.|.||| || || |||| . ... ||...| .. | . . |. ||...    ..|    |.| ... |||||||......|.  ..|..   . .
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekkt

QrgehfGPMIVHCSAGVGRTGTYIVVDIITKMMEynKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
.      |...||||||||||||| .| . | .|  . . |.||.  |. ||..|  ||||  ||.|.| |.. .... 
k.....aplvihCsaGvGrtGtyialDrlvkave..aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPRK_pd Subfamily PTPRK 231-501 1.4e-67 222.7 In-house 21-273 (314) alignment 
Range on Protein: 231-501
Range on HMM: 21-273/314.0
KTGFEEEYQQLQhEGtqhlytRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSS-GNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDS
  || |||. |  ||         | |  ||.|||...||..|..||.|   |    . ||||.....      . .|.||| |. |..||| .|..|..
gygfkeeyeslf.eg......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydenc

KIIVMITNEIERGKNKCARYWPSKGETtlYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYV-VQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEi
  |||.|. .| |. || .||| ..|.  ||.|.|  ..      .| | . .|.....  .. .  |.||  ||||.||.    .|.|.  |. .  | 
asivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.

qqrgeHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
     . |...|||||| |||||.|..||.  |.| ..    .||   |. || ... ||.||.||.|.| .|
.....eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Ptp69D_pd Subfamily Ptp69D 231-506 3.7e-66 218.3 In-house 19-287 (307) alignment 
Range on Protein: 231-506
Range on HMM: 19-287/307.0
KT--GFEEEYQQLQHEgTQHLyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQE
.|  |...||..|... . .. . | . |  |  |||...| .||.|||.|..       .||||....|      . .|| |. . .||.||| |... 
dtdfglakeyekLear.eidk.stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmiaeq

DSKIIVMITNEIERGKNKCARYWPSKgETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKG----RGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNR
....|||..|. |  ..|||.|||   ... ||.| |  ..| .   |. |.|.. .. ...      . ||||... |.|  ||. .  .|.|.. |. 
evtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

KAL-EiqqrgehFGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
    .        .|..|||||||||.|... .|.   ...  | | ..|.   |. ||..|. .||  .|| ||| |.  |..
lykln.......rsPivvhCsaGvgrsgifvalds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 231-505 5.5e-65 214.6 In-house 22-288 (325) alignment 
Range on Protein: 231-505
Range on HMM: 22-288/325.0
KTGFEEEYQQLQHEGTQhlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSG-NTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMV--WQe
. ||  |.. |  ....   ..| |.|| |..||||||....|..||||   . ..   ||||.|.. ..    . ..|.|  |. ||||.| .|  |. 
qdgfahefgllpsddgi...akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk..kkdvflaaqaPltatindlWrlvldWr.

dsKIIVMITNEIERGKNKCARYWPSK-GETTLYGNIQV--INIDEIqgRLYVFRKLHIEHVSkKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRK
    .|...||.. ||..|| ||| . |..  .| ..|  . |.||    || |.|..  |. ||    | |.|.. |.| ||.. |. .. ... |.  
..csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei..sdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkav

ALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVDII-TKMMEynkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
   ..   .  .|..|||||||||||..| .  .  |..|    | ..|. |.|. ||..|  ||.| ||| ..| |.  ..
servtantkastpilvhcsaGvGrtGvfislysalakvie....esrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 231-506 4.5e-53 174.9 In-house 14-294 (301) alignment 
Range on Protein: 231-506
Range on HMM: 14-294/301.0
KTGFEEEYQQLQHEGTQHLYTRKeagKPLNRQKNRFKNILPFDHTRVVLAEP---DSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQE
...|||.|..|...  ..        .  |.. |||||| ..|. |..|..    |.. ..||||.|..|    . . .||.|| .  |. ||| ..|||
snkfeeqykelkegedksctvgl...seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqe

DSKIIVMITNEIERGKNKCARYWPS-KGETTLYGNIQVINIDEIQGRLYVFRKLHI--E------------HVSKKGRGHYVVQYQFKVWPDHGVPQDPS
    |||.||. |. |.|| .|||. . |.. .|...|  ..|     .| |.| .  .            .|...  .. |.|.|   ||..|| ..| 
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

HMLDLMDDVNRKALEIQQrgehfGPMIVHCSAGVGRTGTYIVVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
 .|  .|||  .   |       ||..||||..|.|.|.|. |.|    .|  | |  .|| . .. .|. . |.|.| .|| ..| .|. |..
tvLqviddvihrqqkigg.....gpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 232-501 1e-45 150.8 In-house 6-262 (283) alignment 
Range on Protein: 232-501
Range on HMM: 6-262/283.0
TGFEEEYQQLQHEGTQHLYTRKEAGKpLNRQKNRFKNILPFDHTRVVLaEPDSSgnTYINANYVN-GEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSK
....  ...|.. .  .| .  .. .  |..|||...|.| |  || | ...|   .|||| ..   .    .. ||..|. |  |. ||| ||..|.  
nnnklfrevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvel.ksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

IIVMITNEIERGKNKCARYWPSKGeTTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWpdhgVPQDPSHMLDLMDDVNRkaLEIQQ
 |||.|.  |  . ||..|||..| .  ||.  |   .|   . .. ..| . . |       .  ||.  |    .  ..  ... .  .|.  .  .|
aivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnk..vislq

RGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMeynKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
. .. ||..||||.|.|||...| .    | .   . |  .||   |...| .| ..||| |||.... ..
teskkgPivvhCstgiGrtavfiaasasvkda...ltesvvdvfavvkimreqrmmavqtldqyklvhelv
0046845 (Phosphotyrosine protein) phosphatases II 233-507 1.9e-94 311.4 In-house 1-276 (284) alignment 
Range on Protein: 233-507
Range on HMM: 1-276/284.0
GFEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS--SGNTYINANYVNGEVP---GSGNYYIATQGCLPGTINDFWSMVWQE
|.|||...|..  . .|.... | .| |. |||.|.|||.||.||.|  .|.  ....||||.||.|       . . .||||| ||.|..||| |||..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

DSKIIVMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALE
....|||.|...|.|..|||.|||..||.  ||...| ...| .   |. |.| ..... .|  ..| ..... |||||||..|...|.....|..   .
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

iqqrGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
     .  ||..||||||||||||.|..|.. ...|...  ...||.. |..|| .| |||||..||||.|.|.  |. .
....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 233-511 9.3e-61 200.4 In-house 19-282 (515) alignment 
Range on Protein: 233-511
Range on HMM: 19-282/515.0
GFEEEYQQLQhegTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVL-AEPDSSGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKI
 | ||.. |       .| .  | . .| .|||.|||||.| .|| |    |.  . |.|| |...    . . |||.|| .. ...|||..|.||.   
lfseefhdlp...gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsf..dndkayiasqgPnkasvddfWrlvlqenvtt

IVMITNEIERGKNKCARYWPS-KGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKkgrGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVnrKAleiqQ
|.|.|.  |  | ||..|||   |..  .|.|.|  .        . |||.. . ..    . | |..|. |||.|||.. | .| |. .|  ||    .
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikev..ka....d

RGEHFGPMIVHCSAGVGRTGTYIVVDIItkmMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSL
.|.   |.|.|||||||||| .| .| .   .   |    .||   |. .| .|  .|||..|| |.| |.. ..  |..|
hgqythpliihcsaGvGrtGvvisidsv...vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 233-508 2.1e-58 192.4 In-house 11-280 (287) alignment 
Range on Protein: 233-508
Range on HMM: 11-280/287.0
GFEEEYQQLQHEGTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDSKII
  ..|...|...     .| |.| .  . .|||. ..||.|.|||.|..    |  ||||||| .      . .||.|| .. |..||| .|... |  .
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsasv

VMITNEIERGKNKCARYWPSKGETTLYGNIQVINIDE-IQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNrKALEIQQR
...| |.| ...|| .||| .    . |   |. .|  |.   |  | | . ..  .   . | |...  |||....     .. .. ||. . .|... 
itmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletr.earvvkqldllswPdkvlaPtavglirfvldvk.qhielard

GEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
..  ||..||...|.||.|... . .. ...|      ..||   |  || .| ..||.  |.|.|| |. .| .  
asevGPlvvhddvGiGrsGillatlvlvsrled...lGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
DSPc_SM00195 234-505 1.6e-85 282.0 In-house 2-262 (263) alignment 
Range on Protein: 234-505
Range on HMM: 2-262/263.0
FEEEYQQLQHEGTQHlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKII
..||...|. . ...  . .|| |. |..|||.|||||.||||| | .... .|..||||||..|.   . . ||||||.|| |..||| |||.|..|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkii

VMITNEIERGKNKCARYWPSK-GETTLYGNIQVINIDEIQGR-LYVFRKLHIEHVSKkGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIqq
||.|.| |.||.||.||||.. |... .|.|.| ...... .  .. |.|....  |    . | |||.| |||||||......|.|.  |. .  ..  
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

rgehFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
     ||..||||||||||||....||| . .| .|    .|..  |..||..| |||||..||.|.| || .||
....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 234-505 1.6e-85 282.0 In-house 2-262 (263) alignment 
Range on Protein: 234-505
Range on HMM: 2-262/263.0
FEEEYQQLQHEGTQHlyTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKII
..||...|. . ...  . .|| |. |..|||.|||||.||||| | .... .|..||||||..|.   . . ||||||.|| |..||| |||.|..|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkii

VMITNEIERGKNKCARYWPSK-GETTLYGNIQVINIDEIQGR-LYVFRKLHIEHVSKkGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIqq
||.|.| |.||.||.||||.. |... .|.|.| ...... .  .. |.|....  |    . | |||.| |||||||......|.|.  |. .  ..  
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

rgehFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
     ||..||||||||||||....||| . .| .|    .|..  |..||..| |||||..||.|.| || .||
....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN1_pd Subfamily PTPN1 234-502 1.8e-65 215.5 In-house 8-268 (290) alignment 
Range on Protein: 234-502
Range on HMM: 8-268/290.0
FEEEYQQLQHEGTqhLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSsgnTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIV
..| |.....| .   .. .|| .| ||..||.... |.||.|..| . |     ||||. |  |..     || ||| || |.. || |||...|| .|
ykeiyldirkeas..dfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslv..eleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MITNEIERGKNKCARYWPSKGE--TTLYG--NIQVINIDEIQGRLYVFRKLHIEHVSKkGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAlEIQ
|. . .|....|||.|||.. |  . |.   ...|  | | . . |. |.|..| ..   . . .... .  ||| |||. |. .|... .| .    ..
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresG.sls

qrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIK
   .. || ..|||||.||.||...|| .   .| ..    .|..  .  ||..| |..|| || || | || 
...sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 234-511 8.2e-46 151.1 In-house 22-242 (392) alignment 
Range on Protein: 234-511
Range on HMM: 22-242/392.0
FEEEYQQLQhegTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVL-AEPDSSGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKII
| ||...|      ..| .. | |. | .|||.|||||.| .||.|    |.. . |.|| |...    . . |||.||  . ...|||.||.||.   |
ffeefhdlp...gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqenvtti

VMITNeIERGKnkcarywpskgettlygniqvinideiqgrlyvfrklhiehvskKG-RGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRkaleiqQR
.|.|. .. |                                             ||   . | |..|  |||..||.  | .| .. .|.       . 
amvtk.lkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka......df

GEHFGPMIVHCSAGVGRTGTYIVVDIItkmMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSL
|..  |.|.||||||||||  | .| .   . . |    .||   |  .|..|  ||||..|| |.| |.   .  |..|
Gqythpliihcsagvgrtgvvisidsv...vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 234-500 3.4e-35 116.1 In-house 13-264 (281) alignment 
Range on Protein: 234-500
Range on HMM: 13-264/281.0
FEEEYQQLQHEGTQHLYTRkeAGKPLNRQKNRFKNILPFDHTRVVLAE--PDSSGNTYINANYVNGevPGSGNYYIATQGCLPGTINDFWSMVWQEDSKI
|..|. .|  .    | |     .|.| .|||. ||  .| .|| |    |.     || |||.    |     || |||    |  ||| |.|||..  
fkqefsnlpgdppsdlctv..fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwrmiwqentta

IVMITNEIERGKNKCARYWPSKGETTLY-GNIQVINIDEIQGRLYVFRKLHiehVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMddvnRKaleIQQ
|||. . .|  ..||| |.| .    |   .. |   |    .  |  .|    .| .|  . . .. .| |||  ||.    || ..    ||   |. 
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrln...lsyegetrlithwlwkewpdwqvpessevmlkil....rk...ira

RGehfGPMIVHCSAGVGRTGTYIVVDIITKMMeYNKFEYeIDVQGSVQMLRH-HRSGMVQTEDQYRFLYYA
|     | ..||||||||.|| . |.|  . . ...|    |..  |  ||   |.  ||| .|| ...  
rs...tppvihcsagvgrsgtlmaveialqsi.hshftl.pdikqivshlrvtgraasvqtlqqymliwkv
subfamily_PTPN13_pd Subfamily PTPN13 235-502 7.5e-74 243.4 In-house 14-266 (273) alignment 
Range on Protein: 235-502
Range on HMM: 14-266/273.0
EEEYQQLQHegTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAepDSSGntYINANYVNGEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVM
.||...|..   . | | ... |  |..|||..|.||.|.||| |   |..|  ||||.... .|      |||.|| || |..||| |||. ....|.|
aeefkelre..lkpldtcevgkkkenkdknryrnvlPydetrvklg..degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

ITNEIERGKNKCARYWPSKGE--TTLYGNIQVINIDEIQGRLYVFRKLHIEHVsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRkaleIQQrg
.|.| |.|| || ||||.. .  ..... ..| ...  .   .| |.|..... . |. . |.. .|  |||||||. . ..| ..  |.|    .|.  
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrr....lqt..

eHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIK
 . ||..||||||.||.||.|..|..  ..| .|   |.||.  |. ||. | |.|||.||| | | || 
.dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_PTPN14_pd Subfamily PTPN14 237-507 1.1e-67 223.1 In-house 28-298 (300) alignment 
Range on Protein: 237-507
Range on HMM: 28-298/300.0
EYQQLQHEGTQHLYtrKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSSGNTYINANYVNGEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMIT
||...... .. |.  . |  | | .|||||..||....|| |.    . . ||||  ..  | |.   ||..|| |. |..||| |||... ..|||.|
eyeripkkredall..staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NEIERGKNKCARYWPSK---GETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQQR--
.|.| ||.|. .|.|..    .|  .|. .|..    .   .. ..|...|.  | .   |.  |.. |||||||.|....|. ...|.    . ..   
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

-GEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
  |.  |..|||||||||||  |..|.... .| |.   |||.. ....||. |  .|||  ||.|.| ..  |...
skeskPPvlvhCsaGvGrtGvlilsdlliatlehne...eidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 237-501 6.9e-63 207.8 In-house 3-251 (284) alignment 
Range on Protein: 237-501
Range on HMM: 3-251/284.0
EYQQLQHEGTQhLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMI
|.... . |.. . ... |  . |. |||. .||.||...| |   .   .  |||| ...|    . . |||||| |. |..||| |.|. ..  ||..
efrracklgvn.gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivll

TneiergKNKCARYWPSKGETT-LYGNIQVINIDEIQGrlYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNrkalEIQQRGEH
|      |.||..||| |.. .   ....|  ..| .   || |.... . .|.     . |. |. |||.|||. ||... |.. |.     .... .|
t......kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvr....hltskenh

FGPMIVHCSAGVGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
  ...|||||||||||.|||.|.. ..|.    |  .||   |. ||  |. .||   || |.| |.
ranivvhcsagvgrtgvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 245-506 4.7e-62 204.8 In-house 36-285 (297) alignment 
Range on Protein: 245-506
Range on HMM: 36-285/297.0
GTQHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSS-GNTYINANYVNGEVPgsgnYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGK
 .  ...   | | .| .|.|.|||||.|  || ||  ...    |.|| .|.|        .|.||   . |..||| ||..|. ..|||.... || |
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk

nKCARYWPSKGETTlYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRgHYVVQYQFKVWPDHGVPQ--DPSHMLDLMDDVNRKaLeiQQRGEHfgPMIVH
 ||||||. || || .|.. |.     . . .. |.|.... . | | . | ||||  |||. |..  . | .|.|...|. .    .|. |   |..||
.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkd.f..sqnaeg..Pllvh

CSAGVGRTGTYIVVDIITKMMeynKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
|.||||||| .. .| .   .   | | |.|. | |..||..|  .|||..||.|.| |.  .. 
claGvGrtgvlltidsvvaea...krekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 245-505 1.3e-34 114.3 In-house 41-289 (305) alignment 
Range on Protein: 245-505
Range on HMM: 41-289/305.0
GTQHLYTRKEAgKPLNRQKNRFKNILPFDHTRVVLAEPDssGNTYINANYVNGEVPGsGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKN
 || ..  ...   ..  |||....   |.. | |..|      || ||||   .    . .|..|| |  ||..|| || |.  . |||. . .| || 
mtqvafnanqs.adiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmip.ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl

KCARYWPS-KGE-TTLYGNIQVINIDEIQgrlYVFRK----LHIEHVSKKGR-GHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVnrkaleiqqRGEHFgP
|||.|||  .||  .| . | | |.   .    . |     . . ...  |     | . |.  ||| |||      |.|.  .         || .  |
kcaqywpaaqgeklelksgivvenvsgsk...pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.........rgskv.p

MIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYeiDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
..||||||.||||| . .. | . .  ||      .   |. || .|.  .|.. || |..  .  |.
ivvhcsagigrtgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_eak_pd Subfamily eak 246-510 3.1e-26 86.6 In-house 38-310 (332) alignment 
Range on Protein: 246-510
Range on HMM: 38-310/332.0
TQHLYTRKEAGKPLNRQKNrFKNILPFDHTRVVLAEPDSSGNTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNK
 |.| . .|. .  . ..|   .|.|.|.  | |.      . ||||  .  | .  |. || |       .  || || .. |  ||.. ...| . .|
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

CARYWPSKG-ETTLYGNIQVINIDEIQGRLYVFRKLHiehVSKKGRGHYVVQYQFKVWPDHGVPQ--DPSHMLDLMDDVNRKALE---------IQQRGE
  .|.| |. |   .| ..|   . ..   . .|.|    .||    | |  |..  | .  .|.  |   . . | .|    |          . ..  
sdkyfpdktreelkfGildverkefvkrniletrlle...lskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyi

HFGPM---IVHCSAGVGRTGTYIVVDIITKMMEyNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQS
|  |    |. .. |  |.|...|.|.. .... || .    |.  .   ...|   | .. |. |.| ..  |. ||..
htppsfapiiqsarGsaraGvfvvidllirlid.nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 247-513 1e-61 203.5 In-house 31-285 (315) alignment 
Range on Protein: 247-513
Range on HMM: 31-285/315.0
QHLYTRKEAGKPLNRQKNRFKNILPFDHTRVVL-AEPDSSGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNK
   | .. | .. | .|||.|||||.|..||.|    ||  . |||| |...    . . |||.|| |. ...|||.||.||.   |||.|.  |  | |
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksv..dddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CARYWPS-KGETTLYGNIQVINIDEIQGRLYVFRKLhIEHVSKkgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKaleiQQRGEHfgPMIVHCSA
|..|||  |.... .|.|.|  ..  .    | ||| .   |.    . | |.||. |||.||... | .| |. .|  .    ... |.  ...|||||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkad....ngkkef..sllvhcsa

GVGRTGTYIVVDiitKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSLNE
||||||  | .|   ....  | .  .||   |..|| .|  .||||..| |.| |.. ..  |..|  
GvGrtGvvisid...evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlil
subfamily_CG42327_pd Subfamily CG42327 249-422 3.7e-31 102.9 In-house 17-191 (319) alignment 
Range on Protein: 249-422
Range on HMM: 17-191/319.0
LYTRKEAGKPLNRQKNRFKNILPFDHTRVVLA-EPDSSGNTYINANYVNGEVpGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCA
| .| ..  .  ..|.|. |..|. .|||||   .|   . |..|.|| |    . |.|||.|  |  .  ||| .||.  |..|| .|.  | | ..||
liaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvca

RYWPSKG---ETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFkVWPDHGVPQDPSHMLDLMDDVN
.|.|.|    .| |||.|.|   .   .  |.   | . .| |.     .  | .  |.. .|| ... .. .. .|.
eylPtketldntslyGdilvtlkgrevkdryaistlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevr
subfamily_PTPN3_pd Subfamily PTPN3 251-503 6.5e-76 249.9 In-house 32-273 (280) alignment 
Range on Protein: 251-503
Range on HMM: 32-273/280.0
TRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDSsgnTYINANYVNGEVPGSG--NYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCAR
. ..| || | .|||...|||.|.||| | | ..    |||||||| |.|..|  | |||||| |. | .||| |||...|..|||.|. .|||. || .
aisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPSKGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqrGEHFGPMIVHCSAGVGR
|||...... ||...|    | . . ||.|.| ... ..| . . ..| |.  |||||||.|....|.... |...         .  |..||||||.||
yWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGigr

TGTYIVVDIITKMMEYNKFEYEIDVqgsVQMLRHHRSGMVQTEDQYRFLYYAIKA
|| .|....   ..| ..  | .|.   |...|  |. .|||..||.|.  || .
tGvlilletalalieaaepvypldi...vrtmrdqramlvqtasqykfvCeailk
0049772 (Phosphotyrosine protein) phosphatases II 251-513 2.1e-43 144.6 In-house 37-288 (314) alignment 
Range on Protein: 251-513
Range on HMM: 37-288/314.0
TRKEAGKPLNRQKNRFKNILPFDhTRVVLAEPDSSGNTYINANYVNGEvpgsgNYYIATQGCLPGTINDF----------WSMV--WQEDSKIIVM----
|.. | ..||| |||...|||.| .||.|   . ||  ||||.||.|      . .||||| |. |..||          |.||  .. .. .|||    
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------ITNEIERGknkcarywpskgettlyGNIQVINIDEIQgrlyvfrklhieH--VSKKGRGHYVVQYQFKVWPDHGVPqDPSHML
                 ...  ..|                 .   . ......                ...   .....|    .||...| ......
vladelsrLdaAlgKtpllildgng.................neptaadlellk............eelydpelferlgikylripvpDgsap.lledfd

DLMDDVNRKaleiqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMeynkfeyEIDVQGSVQMLRHHRS-----GMVQTEDQYRFLYYAIKAYIERRQS
.... ...         .  || .|||.||.|||||..|.... | .        ....  ....|  |.     |.... .|| | ..|.. |... ..
eflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk

LNE
 .|
fye
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 251-337 8e-10 32.7 In-house 30-118 (347) alignment 
Range on Protein: 251-337
Range on HMM: 30-118/347.0
TRKEAGKPLNrqKNRFKNILPFDHTRVVLAePDSS-------GNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITN
| .|  | |.  ||| |.    | |||||. |. |        .||||| ... .   . . || ||  || |. ||| ||       .| | .
tsveweksls..knrskdvklidatrvvls.peksknsraddvetyinashikfd..naskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 251-297 5.3e-08 26.6 In-house 38-85 (440) alignment 
Range on Protein: 251-297
Range on HMM: 38-85/440.0
TRKEAGKPLNRQKNRFKNILPFDHTRVVLAEPDS-SGNTYINANYVNG
  . |. | |. |||..||| .||.||.| |  .   . |||| |.||
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
0045098 (Phosphotyrosine protein) phosphatases II 252-507 1.1e-77 256.5 In-house 25-274 (278) alignment 
Range on Protein: 252-507
Range on HMM: 25-274/278.0
RKEAGKPLNRQKNRFKNILPFDHTRVVlaepdssgnTYINANYVNGEvpgsGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWP
  .| .. |. |||.|.|||.||.||.          ||||.|..|     .. .|||||.|| |..||| |.|......|||.|...|.|..|||.|||
itpalylgnldknRykdilpydhsrVk.........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

SkGETTLYGNIQVINIDEIQGRLYVFRKLHIEHV---SKKGRGHYVVQYQFKVWPDHGVPQDP--SHMLDLMDDVNRKALEIQQRG--------EHfGPM
. |..  ||...| ...| .   |. |.|.....    . .  ..| ..... ||||||| .|  ...|.|.. ...   .....         .. ||.
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.gpv

IVHCSAGVGRTGTYIVVDIITKMMeynkfEYEIDVQGSVQMLRHHRSG-MVQTEDQYRFLYYAIKAYIER
.||||||||||||....... ...     |  .|..  |..|| .| | .||...||||||...  ...|
lVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 252-505 3.1e-75 248.3 In-house 3-246 (249) alignment 
Range on Protein: 252-505
Range on HMM: 3-246/249.0
RKEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYW
...| .| |. |||...|||.||.||.|   |.  .. ||||.|.  ... ... .|||||.||.|..||| |.|......|||.|.. |.|..|||.||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PSkGETTLYGNIQVINIDEIQGRLYVFRKLHIEHVsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIqqrgEHFGPMIVHCSAGVGRTG
|. |... ||...| ......   |. |.|..... ..|  ..| ..|.  |||||||......||... |.    |.    .  ||..|||||||||||
pl.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtG

TYIVVDIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
|.|. ...  ..|..   ...|..  |..||..|.|.||...||||||.|.. ..
tfiaaylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 252-407 7.5e-14 45.9 In-house 88-235 (244) alignment 
Range on Protein: 252-407
Range on HMM: 88-235/244.0
RKEAGKPLNRQKNRFKNILPFDHTRVVLAEpDSSGNTYINANYVNgeVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNeIERGknkcARYWP
 |.| .| |  |||    ||||  || |..  | ||||||| .|     |    || ||  |  |  ||| |. .   ...|..   .|        |||
mkdafnpnnswknregaglpfdfnrvplsk.gsmgntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywp

SKGETTLYG-NIQVINIDEIQGRLYVFRKLHIEhvSKKGRGHY-VVQYQFKVWPDHGV
       |  .| |   |  . .     .| ||  |     |  .  .|   ||  | 
dseplewyeeditvtltdrdefknikasnleie..sdmneshqaltmfqisnwpsdgt
subfamily_ptpA1_pd Subfamily ptpA1 253-464 4.2e-44 145.9 In-house 40-258 (418) alignment 
Range on Protein: 253-464
Range on HMM: 40-258/418.0
KEAGKPLNRQKNRFKNILPFDHTRVVLAE-PDSSGNTYINANYVNGEVPgsgNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWP
 |  |  |  |||. |||| .|||| | .  |  |. ||||||..|  |   . .|.||| || || ||| |||..  .||||.. | |  . || ||||
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp

SK--GE-TTLYGNIQVI-------NIDEIQG--RLYVFRKLHiehVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQQRGEHFGPMI
 .  ||  ..||| . .        .. ||   |  . |...   .. .|  . . |||.. |||| .|.    . .|.  .  .  .|    ..  |.|
eqiggeqfsiygngnevfgtysvelveviqdpereiitrnir...ltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGVGRTGTYIVVDIITKMMEY
||||||||||||.    |. | ...
vhcsagvgrtgtfctavimmkkldh
0037934 (Phosphotyrosine protein) phosphatases II 255-504 2.1e-75 248.7 In-house 5-241 (243) alignment 
Range on Protein: 255-504
Range on HMM: 5-241/243.0
AGKPLNRQKNRFKNILPFDHTRVVLaepdsSGNTYINANYVNGEvpgsgNYYIATQGCLPGTIND----FWSMVWQEDSKIIVMITNEIERGKNKCARYW
| .| |. |||...|||.||.||.|     .|. |||||....      ...||||| ||.|..|    || |.|......|||.|...|.|..|||.||
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PskGETtLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALE-----IQQRGehfGPMIVHCSAG
|  ||.  ||...| ...| ..  |. |.|..|... ..  ..|..|..  |||||||..|...||..|.|.    |        .|   ||..||||||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHCsaG

VGRTGTYIVVDIITKMMeynkfeyEIDVQGSVQMLRHHRSG-MVQTEDQYRFLYYAIKAY
||||||.|. ... ...       ..|..  |..|| .|.| .|||..||||||.|.. .
vgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 255-510 5.2e-67 220.7 In-house 4-247 (250) alignment 
Range on Protein: 255-510
Range on HMM: 4-247/250.0
AGKPLNRQKNRFKNILPFDHTRVVLAEPD-SSGNTYINANYVNGEVpGSgNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNkCARYWPSK
| || |..|||. .|...|..|||| . .      |||| ...|   .. . .||||| |. ||.||| ||..|.|. |||.||  | .|. . .||| .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

GeTTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRgHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKaleiQQRGEHfGPMIVHCSAGVGRTGTYI
. .. ||...|   .. .   |. ||| . . .|...   |.|..| |||| |||.    .|.|...|...    ||. .  .|.||.|||||||.|..|
k.aekyGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqas....qqqagn.aPvivqCsaGvgrsGafi

VVDiitKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQS
..|    ..|  | |  .||   ...||..| ..|....|| |.| .|. ...  . 
aid...avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsved
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 255-501 8.2e-53 174.0 In-house 3-237 (239) alignment 
Range on Protein: 255-501
Range on HMM: 3-237/239.0
AGKPLNRQKNRFKNILPFDHTRVVLAEPD-SSGNTYINANYVNgEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSk
| | .|. |||. ||. .||.|||| .      . ||||.|.  .  || . |||||||.  .  ||| |.|||   .|||.|  ||  |.|| .|||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.

gETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQQrgehfgPMIVHCSAGVGRTGTYI
  |. | |..|          |. | . . .| .    .|| ||.| ||||.||||  . .| |   . . .|   .      | ..||||||||||...
.stskycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar......pwvihcsagvgrtgafl

VVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
|.|    |.   | .  .|.   |. .|  |  |||| .|| |.. |.
vida...mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 255-501 1e-52 173.7 In-house 2-236 (239) alignment 
Range on Protein: 255-501
Range on HMM: 2-236/239.0
AGKPLNRQKNRFKNILPFDHTRVVLAEPD-SSGNTYINANYVNgEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSk
| | .|. |||. ||. .||.|||| .      . ||||.|.  .  || . |||||||.  .  ||| |.|||   .|||.|  ||  |.|| .|||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.

gETTLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKgRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQQrgehfgPMIVHCSAGVGRTGTYI
  |. | |..|          |. | . . .| .    .|| ||.| ||||.||||  . .| |   . . .|   .      | ..||||||||||...
.stskycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar......pwvihcsagvgrtgafl

VVDIitkMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
|.|    |.   | .  .|.   |. .|  |  |||| .|| |.. |.
vida...mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
0042113 (Phosphotyrosine protein) phosphatases II 256-506 1.1e-75 249.5 In-house 5-244 (245) alignment 
Range on Protein: 256-506
Range on HMM: 5-244/245.0
GKPLNRQKNRFKNILPFDHTRVVLAEPDSS-GNTYINANYVngEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSkG
 .| |..|||...|||.|||||.| ..... ...||||.||   ..   . .||||| ||.|..||| |.|......|||.|.| |.|..|||.|||. |
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

ETTLYGNIQVINIDEIQGRLYVFRKLHIEHvSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEiqqrgEHFGPMIVHCSAGVGRTGTYIV
|.. ||...| ...| .   |. |.|....  ...  . |..|..  ||||||| .....||... |..   |        ||..||||||||||||.|.
esltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfia

VDIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
....  ..|..   ......  |..|| .|.|.|||..||||||.|.. ...
aylmleqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 257-508 2.1e-72 238.5 In-house 25-271 (274) alignment 
Range on Protein: 257-508
Range on HMM: 25-271/274.0
KPLNRQKNRFKNILPFDHTRVVLAEPDSSG--NTYINANYVNGEVpGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKG
 . . .|||.|.||| ...||.| . .|.    .||||||. |   .  . |.|||| || |..||| |..||....|||.|.  |. ..|||.|.| . 
vfgsqtknryktilPnensrvllesessededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

ET---TLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRghyVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiQQRGEHFGPMIVHCSAGVGRTGT
..     ||.... . . ..   |  ||| ....... .   |. | .  |||| .|.|....|||...|....   ... .. .|..||||||.|||| 
dyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesr...eeenaklapvvvhCsaGiGrtGc

YIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
.| ..|  . ..    |  .|| . |  || .| |||||..||.... |.  | .| 
fiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_CG7180_pd Subfamily CG7180 257-505 6.8e-46 151.2 In-house 39-290 (296) alignment 
Range on Protein: 257-505
Range on HMM: 39-290/296.0
KPLNRQKNRFKNILPFDHTRVVLAEPDSS-GNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKnKCARYWPSKGe
.  ||.|||  ...|.|..|||| . |    . |||| ||.. .    . || |..    |...||..|..|... .|..|.. .  | ..  ||| |. 
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

TTLYGNIQVINIDEIQGRLYVFRKLHIEHV---------SKKGRGHYVVQYQFKVWPD-HGVPQDPSHMLDLMDDVNRKALEIQQRgEHFGPMIVHCSAG
 . ||.| |  . | |    . |.... .            |     | ..|...|.  . ||   . ...|.  |.    ..... .. ||..|..| |
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvded.peegPvvvvssdG

VGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
..|.| |. .|.   ..|    | |.|| . |..||..| ..|.. ..|...|  .. ..
asRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 257-412 1.4e-31 104.5 In-house 30-184 (297) alignment 
Range on Protein: 257-412
Range on HMM: 30-184/297.0
KPLNRQKNRFKNILPFDHTRVVLAEPdSSGNTYINANYVNGEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSK-GE
..   .|||...|| .| ||| |     ... ||||.||      .  .|| .|| |  |..||| .|...| ..|||...  | |..||| ||||  .|
rnsslrknryrdilatddtrvkllrv.iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

TTLYGNIQVINIDEIQGRlyvFRKLHIEHV--SKKGRGHYVVQYQFKVWPDHGVPQDPS
    |.. |  . .       | ....  .    . .  .|   ||  ||||||| |  
rlkagdvvveflsstsde...fdrviltelqliyrsesrvvrhvqflswpdhGvpsdle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 259-509 1.9e-39 130.5 In-house 40-282 (307) alignment 
Range on Protein: 259-509
Range on HMM: 40-282/307.0
LNRQKNRFKNILPFDHTRVVLAEPDSSgNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPS-KGETT
 | .|||....   |..|.|.  .  .   || |||.   .    . .|..|| |  |. .||.|. ||. . ..|. . || .| || .|||  .|.. 
antdknryqdvkcqdkgrivvkfdgla.sdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

LYGNI-QVINIDEIQGRLYVFRKLHIE----HVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqrgehfGPMIVHCSAGVGRTGTY
 .|.  . |.....  .     .  |.    .|   ..   . ..|.. |||.||||     ..|.. |. .            |..|||||||||.|| 
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt..........npvvvhcsaGvGrsGti

IVVDII-TKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY-IERRQ
. . ..  ||..    .   |..  |. || .|   .||| || .|.  .  | .|. .
vaislvqdkmiaG...inckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 259-496 8.3e-36 118.3 In-house 49-272 (301) alignment 
Range on Protein: 259-496
Range on HMM: 49-272/301.0
LNRQKNRFKNIlPFDHTRVVLAEPDsSGNTYINANYVNGEvpGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTL
|...|.|.... | . .  |    |      | ||... .  |  . .||||| |. | .||| |. | | . |||.....|. ..||. | |.| . .|
lpkdkhryptv.PckPstavevivd.GkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

Y---GNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKaleiqqrgEHfgPMIVHCSAGVGRTGTYIVV
     .|.. | . |     . |.|..|  ..|   . |. ||.. |.|.|||.   .. |||. | .         |.  |..||||||.||. ..|  
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks........ek..PivvhcsaGiGrsvafigt

DIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRF
..... .| ..   .|... ... ||.||   |||. |  .
eylareveadp...tieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 259-514 8.9e-36 118.2 In-house 47-296 (305) alignment 
Range on Protein: 259-514
Range on HMM: 47-296/305.0
LNRQKNRFKNILPFDHTRVVLAEPdsSGNTYINANYVNgeVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTL
 ...|||.|..  .|. || |  |      || ||||    |   . .| ||  |  |  ||| | .|.  . | |. | .|.| .||. |..|| . .|
qeagknrykdvgcldnnrvklegp..wpheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

Y--GNIQVINIDEIQGRLYVFRKLHIEHVSK-----KGRGH---YVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqrgehfGPMIVHCSAGVGR
    . | | .       . |||    .|..     .| |.    | .| .  ||| |||     .|.|. .               ||..||||||.||
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..........gpivvhcsagigr

TGTYIVVDIITK-MMEYNKFEyeiDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSLNEA
||. .... | . ... .. |   | .  .| .|  |   .||..|| |..  |  |..... |.|.
tgsvvmleyildqllagqiie...dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee
subfamily_egg_pd Subfamily egg 259-505 7e-25 82.3 In-house 39-270 (307) alignment 
Range on Protein: 259-505
Range on HMM: 39-270/307.0
LNRQKNRFKNILPFDHTRVVLAEPDSS-GNTYINANYVNGEvPgSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERgkNKCARYWPSK-GET
 |..| | | .   | .|| |  .     . .| ||.|.|. |   | .| .|  |  | .||| ||.||. . |||.|   |   ..|  |||    ..
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGk.p.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

TLY--GNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVwpdhgvpQDPSHMLDLMdDVNRKALEIQQrgehfgPMIVHCSAGVGRTGTYIV
  .  |.... |..  .    .||  ..  |  .    ..  .|  |       .  |..   .  | ||. .. .      |..|..  || ...| . 
lvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdv.......nnssdvyspl.rvlrklrnlsk......pvvvqdilGvskaatlva

VDIIT-KMMEYnkFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
..|   ...      .   |. .|..|| .|   |..  .| |.|  .  ..
ieiallsllrG..pitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 259-311 5.4e-09 30.1 In-house 47-95 (95) alignment 
Range on Protein: 259-311
Range on HMM: 47-95/95.0
LNRQKNRFKNILPFDHTRVVLAEPDSSgnTYINANYVNGEVpgSGNYYIATQG
 |  |||| ||.|.| |||||.    |   |||| .|.|      | |||.||
anipknrflnifpydatrvvlttkrds..dyinacfvdgya..rkncyiaaqg
Y_phosphatase Protein-tyrosine phosphatase 260-501 1.2e-77 255.9 Pfam-A 1-233 (235) alignment 
Range on Protein: 260-501
Range on HMM: 1-233/235.0
NRQKNRFKNILPFDHTRVVLA-EPDSSGntYINANYVNGEVpGsGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWP-SKGETT
|..|||.|.|||.|.||| |  ....|   |||||||.|      . .|||||.|. ||.||| |||||..|.|||.|.. |.|..|||.||| ...|..
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

LYGNIQVINI-DEI-QGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqrGEHFGPMIVHCSAGVGRTGTYIVV
 ||.|.| .  .|  .   |..|||....  .. . . | |.... |||||||..|...|||...|...        .. ||..||||||||||||....
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfval

DIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
||. ...| ..    .||   |..||..| ||||...|| ||| ||
dilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 260-501 1.2e-77 255.9 In-house 1-233 (235) alignment 
Range on Protein: 260-501
Range on HMM: 1-233/235.0
NRQKNRFKNILPFDHTRVVLA-EPDSSGntYINANYVNGEVpGsGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWP-SKGETT
|..|||.|.|||.|.||| |  ....|   |||||||.|      . .|||||.|. ||.||| |||||..|.|||.|.. |.|..|||.||| ...|..
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

LYGNIQVINI-DEI-QGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqrGEHFGPMIVHCSAGVGRTGTYIVV
 ||.|.| .  .|  .   |..|||....  .. . . | |.... |||||||..|...|||...|...        .. ||..||||||||||||....
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfval

DIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
||. ...| ..    .||   |..||..| ||||...|| ||| ||
dilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 260-509 6e-70 230.3 In-house 20-268 (270) alignment 
Range on Protein: 260-509
Range on HMM: 20-268/270.0
NRQKNRFKNILPFDHTRVVLAEPD-SSGNTYINANYVNGEvPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGET--
... ||...|||  .|||.|.| .  |  .|||||||.|   |. ..|||..| || |...|| |.|.| .. |||.|.  |.|..||.||||.. ..  
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGf.dgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-TLYGNIQVINIDEIQGRLYVFRKLHIEhvsKKGRGHYVVQYQFKVWPDHGVPQDPS------HMLDLMDDVNRKALEIQQRgEhfgPMIVHCSAGVGRT
 . .|.|.|... | . . |....|..|   .||  . .| .... |||||||...       ..| .. .| |   | ..  |   |..||||||||||
kledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka.e...PllvHcsaGvgRt

GTYIVVDIITKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQ
|| |..||.....| .|   ..||   .. ||..|  .||. .||.||| |.  |.|||.
GtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 260-501 2e-55 182.6 In-house 3-235 (237) alignment 
Range on Protein: 260-501
Range on HMM: 3-235/237.0
NRQKNRFKNILPFDHTRVVLAEPDSSgNTYINANYVNGeVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTLY
|. |||. ||  .||.||||  . |.   ||||.|..| . |. . |||.|| |  . .||| |||||   .|||.|  ||. . || .||||  . . |
nkiknrygnivaydhsrvvlkgagsg.sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIqqrgEHFGPMIVHCSAGVGRTGTYIVVDIit
| . |    . .   |  | | . .  ..    .. |||| .|||.||||  . .| .  ..  ..  .     . || |.|||||||||| ..|.|   
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv....sesgpwiihcsagvgrtgiflvida..

kMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
 |.   | .  .|.   |. .   |  ..||.||| |.. .|
.mlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 260-507 4.8e-50 165.0 In-house 1-173 (182) alignment 
Range on Protein: 260-507
Range on HMM: 1-173/182.0
NRQKNRFKNILPFDHTRvvlaepdssGNTYINANYVNGEVPGSGnyYIATQGCLPGTINDFWSMVWQEDSKIIVMITneiergknkCARYWPSKGettly
|. |||...|||.||.|         ...|||||.. |  |..   .||||| |..|..||. |..... ..||..|         . .|||..      
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

gniqvinideiqgrlyvfrklhiehvskkgrGHYVVQYQFKVWPDHGVPQdPSHMLDLMDDVNRkaleiqqrgeHFGPMIVHCSAGVGRTGTYIVVDIIT
                                ....||..  |||||||  ....||....|..          . || .||||||||||||... ... 
...............................erlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmk

KMmeynkfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIER
|.        .....  |...| .|.|||.|..||.||..|.  ....
kl........gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 260-501 5.9e-44 144.8 In-house 56-279 (290) alignment 
Range on Protein: 260-501
Range on HMM: 56-279/290.0
NRQKNRFKNILPFDHTRVVLAepDSSGNTYINANYVNGEVPgsgnYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSK-GETTL
. .|||.|..   | |||.|   |     |. ||||.|  .     .| ||| |  |. |.| || ||.   |||. . || || ||..|.| | ||.  
efkknrykdvvcndktrvilk..dGydGdyvhanyvkGlka....mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVnRKALeiqqrgehfGPMIVHCSAGVGRTGTYIVVDII
.|.| |.   | .    . .|.      ..|. | .  .. | |||. |..    .| ..  . |||          ||..||||||.|||||.. ... 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.rkas.........GpvvvhcsaGiGrtGtfvaievg

TKMMEYNKfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
 ...   |   |.|. . |. ||. | . || . ||  |  ..
lqilldGk...eldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 260-506 6.5e-34 112.1 In-house 33-260 (267) alignment 
Range on Protein: 260-506
Range on HMM: 33-260/267.0
NRQKNRFKNILPFDHTRVVLAEPDSSgntYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEierGKNKCARYWPSK-GETTL
|...||. . ||.|.|||.| . .     |||| ||.|     .| .|.||. |  || ||. .. ...  .||..|.    ....  ..|| | |..  
nqernrlddnlpyddtrvilrtkeee...yinasyvegyk..tknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

YGNIQVINIDEIQGRLYVFrkLHIEHVSKKGRGHYVVQYQFKVWPDHGvPQDPsHMLDLMDDVNRKALEIQQRgehfgPMIVHCSAGVGRTGTYIVVDii
| .. |    | .   |    . .|   |.   | |. | .| |      . | ..  |.  . .. ||  .|     |..|.||.||||.||..|.|  
yqdltvehslekeendyqi..itlelkfknesahnvtlyyykkwnint.nnkp.ylkplfgilaknqlengnr.....PlvvacsdGvGrsGtflvid..

tKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
  ..|  | |   |.   .. .|. | |.|.| ..| ...  .  | |
.sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 260-508 2.8e-33 110.2 In-house 43-274 (288) alignment 
Range on Protein: 260-508
Range on HMM: 43-274/288.0
NRQKNRFKNILPFDHTRVVLAepdSSGNTYINANYVNgevpgSGNY---YIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPS-KGE
|  ..|..|.   | ||| |       . ||.|| |      |..|    | .|  | |||. .| |. ..| . |||... .|.||.| | |.|| .||
nptrdryenlprcditrvkls...ddpdfyiaanvvs.....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe

TTLYGNIQVI---NIDEIQgRLYVFRKLHIEHVSKKGRghYVVQYQFKVWPDHGVPQDPSHMLDLMDDVnrkaleiqqrGEHFGPMIVHCSAGVGRTGTY
.. .| .  .   . ..|. .| .   |.|... ..    .| .  .. |.|.|||..    | |.. .           ..  |..||.||||||||| 
karigrlctvvkkkradid.klvkvsllriskegeekv..ivkilhlleWdddgvPenylsplrllevl..........kslqkPivvhssaGvGrtgtl

IVVDIITKMMEYNKFeyeIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERR
|.. |. ...  . |   . ..  .. || .|   .||| || ...  .. ..  .
ililialeslrlddf...lgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 260-505 5.1e-32 106.0 In-house 35-270 (285) alignment 
Range on Protein: 260-505
Range on HMM: 35-270/285.0
NRQKNRFKNILPFDHTRVVLAEPDssgNTYINANYVNgeVPGSG-NYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSK-GETT
| . ||. ..   . ||||| . |     || |...   .||   . ||.||| || |..||| |..||    ..|.   .| | .||| |.| | ||  
npdlnryadvrcieetrvvlknhd...rdyihaswmr..mpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LYGNIQVI--NIDE--IQGRlyVFRKLHIEHV-SKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRkaLEIQQRgehfgPMIVHCSAGVGRTGTY
 .|. ..   .  |  | |   ..  | .           |. . |   |||.  |.|   |..|   |..  .. ...     |. |||||||||| |.
kfgkyeitlteckeeaiagt..ilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk..vnpkek.....picvhcsagvgrtatf

IVVDIIT-KMMEYNkfeyEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYI
. .|  | ..||      .|..   |. .|  |   ||.  |. |||  .  |.
vgidyatirimenp....niemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 260-509 8.3e-16 52.3 In-house 51-289 (302) alignment 
Range on Protein: 260-509
Range on HMM: 51-289/302.0
NRQKNRFKNILPFDHTRVVLAEpdsSGNTYINANYVNgeVPGSGNYYIATQGCLPGTI---NDFWSMVWQEDSKIIVMITNEIERGKnKCARYWPSKGET
| .||. ...   |...| |..   . . |.||  |.  ||  ..  | .|    ..    ..|| ||.||  . .|..  | |  |     ..| | ..
nlkknqsedvpildsnlvklea...epdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

TLYGNIQVINIDEIQGRLYVFRKLHIEHVSKKGRGHYV-VQYQFKVWPDHGVPQDPSHMLDLMDDVnrkaLEIQQRGEHfgPMIVHCSAGVGRTGTYIVV
 .. .   .|.  ..       .. || . .      .   | .. |... ||.  ...   . .|     . .. ...  ....    |.|| |. ...
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv....fakkikade..ntvivSknGaGRagafltl

DIITKMMEYNkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQ
 .  . .. .    |  ..  |. .|  |. .|.. .|| .|| |.  || .. 
avaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 260-504 8.8e-16 52.4 In-house 47-278 (303) alignment 
Range on Protein: 260-504
Range on HMM: 47-278/303.0
NRQKNRFKNILPFDHTRVVLAepDSSgntYINANYVNGEvpgSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTLY
| .|||| ... .||..| |.  |||   || |.|.. .   | .  | ||  |. |  ||| |. ..  | ....  . |  |      .| . .   .
nmdknrfvdvicldhskvkls..dss...yihasyleld...sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GNiQVINIDEIQ-GRLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMldLMDDVNRKALEIQQRGEHfGPMIVHCSAGVGRTGTYIVVDii
 . ..| . |..   |    .|..  ||.     ..  ...| ||   .| | |    .. .. .    ...  .   | .    .|.||.||. . .  
ee.rsirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspk..fvkqiwqlqsvlrkysds.tptvymslsgcgragtfalfe..

TKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY
|  .   . .  .|.   ....|  |   ||   |. ..|  .  .
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 262-354 2.4e-26 87.3 In-house 49-154 (350) alignment 
Range on Protein: 262-354
Range on HMM: 49-154/350.0
QKNRFKNILPFDHTRVVLA---------EPDSSGNTYINANYVNGEVPG---SGNY-YIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCAR
 |||.|||||..|.|| |          .   |.| ||||||.. ....     .. |||||. || |..||. .. . . |.|...|...| . .|| |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSKG
||.  .
YWqegs
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 262-504 2.4e-25 83.9 In-house 45-275 (312) alignment 
Range on Protein: 262-504
Range on HMM: 45-275/312.0
QKNRFKNILPFDHTRVVLAEPDssgNTYINANYVNgeVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKG------E
. ||. ||  .|  |  ||  .   | || ||.|.  .    . ...||| |  |.  || ..    |  |....  .| | .|||.|           .
dlnrypniqcwdrgrftlagde...nfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

TTLYGNI-QVINIDEIQGRLYVFRKLHIeHVSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqRgehfgPMIVHCSAGVGRTGTYIV
  .| .    |.|          | |..  |   |.   . .||.  |||||.|.     | |.  |..       .     |.| ||||||||||| ..
hrvyteycteieiggkskdkithrvlkv.vvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.....k.....pviahcsagvgrtgtlal

VDiitKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY
..    |.   .     .|. |  .||. |.  |..  || .   ..  .
ie...smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 262-353 7.7e-17 55.6 In-house 50-156 (349) alignment 
Range on Protein: 262-353
Range on HMM: 50-156/349.0
QKNRFKNILPFDHTRVVLAEPDS---------------SGNTYINANYVNGEVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKC
 |||.|.|||..|.||.| .                    . ||||||..       . |||||  || |..||. ..  .  |... .... | . .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

ARYWPSK
 .||   
diywqel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 265-504 3e-20 67.5 In-house 24-258 (290) alignment 
Range on Protein: 265-504
Range on HMM: 24-258/290.0
RFKNILpFDHTRVVLAEPDSS-GNTYINANYVNgeVPgSGNYYIATQGC-------LPGTINDFWSMVWQEDSKIIVMITNEIERGKN----KCARYWPS
| .. | . .||||| .  .   . || ||.|   .| .|   |.||            ||..|| |. || .| .||. .  |. .|     ||.| | 
RlevpL.veatrvvLkgygkrfnddyiHAnrvt..cp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KGE-TTLYGNIQVINIDEIQGRLYVFRKLHIEHvsKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiqqrgehfGPMIVHCSAGVGRTGT
. .    .....|   . ..      |.| ...   ... . |  ...| | .  |..|.  .|.|.. |. .            |.||||  |. |  .
svgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkask..........tpvivHcvdGiSrsAa

YIVVDIITKMMEYNkfEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY
   ...   ..     . .. ..  ...||..|  ..... .. |  ..|  .
laaiilgyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagivll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 270-406 6.2e-07 23.8 In-house 3-125 (130) alignment 
Range on Protein: 270-406
Range on HMM: 3-125/130.0
LPFDHTRVVlaepdssGNTYINANYVNgeVPGSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNeIERGknkcARYWPSKGETTLYGNIQVINIDE
|.|. .|.        |||||||..|   . |  . |. ||  |  |  ||| |. .    ..|..   .|        |||       | .  .. . .
lefevsrlq.......gntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltd

IQGRLYVfRKLHIEHVSKKGRGHY-VVQYQFKVWPDHG
 ..  .. .  ..|  |.  . |  .  .|   ||  |
rdefkni.kasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 271-504 3.7e-34 113.3 In-house 1-170 (178) alignment 
Range on Protein: 271-504
Range on HMM: 1-170/178.0
PFDHTRVVLAEPDS-SGNTYINANYVNgevpgsGNYYIATQGClpgtiNDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGEttlygniqvinide
|.|.|||.| ..    .  ||||...       ...|......      |.. ...... . ||..|.|.|.|..|| .|||.. .              
pldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

iqgrlyvfrklhiehvskkgrghyvVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKAleiQQRGehfGPMIVHCSAGVGRTGTYIVVDIITKMmeynkfey
                         .||..  .||||||. ..|.|.... ...     ...|   || .|||||||||.|| .. ... |.        
.........................iqylhipipDhgvpdllehflefvefieeal...dekg...gpvlVHCsaGvgRsgtlvaaylmkkl........

EIDVQGSVQMLRHHRSgMVQTEDQYRFLYYAIKAY
 ....  ....| .|. .|....|.|.||.  . .
glsleeaielvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 284-506 4.3e-43 142.4 In-house 9-174 (176) alignment 
Range on Protein: 284-506
Range on HMM: 9-174/176.0
SSGNTYINANYVNGEvpgsgnYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTLygniqvinideiqgrlyvfrklhie
  . .|||||.. |       ..||||| ||.|. ||. |..... ...|..|.|.| |. ||..|||   .  .                         
dldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

hvskkgrghyvvQYQFKVWPDHGVPQDpSHMLDLMDDVNRkaleIQQRGehfGPMIVHCSAGVGRTGTYIVVDiitkMMEYnkfEYEIDVQGSVQMLRHH
            ||..  |||||||.. ...|.|.. ...     ...|   || .||||||.|||||... .    ..|.   |. ..|.  ....| .
............qylhlpwpDhgvpdl.elllellefire....alkeg...gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvreq

RS-GMVQTEDQYRFLYYAIKAYIE
|. |.|||..||||||.... ...
RplgavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 285-499 9.4e-42 138.0 In-house 3-155 (172) alignment 
Range on Protein: 285-499
Range on HMM: 3-155/172.0
SGNTYINANYVNGEVpgSGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEiergknkcarywpskgettlygniqvinideiqgrlyvfrklhieH
.|..||||.|... .    . .|||||.|. |..||| |..... ..||..|..                                              
egsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

VSKKGRGHYVVQYQFKVWPDHGVPqDPSHMLDLMDDVNRKAleI--QQrgehfGPMIVHCSAGVGRTGTYIVVDIITkmmeynkfeYEIDVQGSVQMLRH
. ...  ....||..  ||||||| .....|.... .....  .  ..     ||..|||||||||||| .. ...          . ....  |...|.
ydpellerlgiqylylpwpDhgvp.llellleflefidell..alspg.....gpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvre

HRSGMVQTEDQYRFLYY
.|.|.||...|||||||
kRpgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 286-499 2.3e-42 140.0 In-house 1-164 (174) alignment 
Range on Protein: 286-499
Range on HMM: 1-164/174.0
GNTYINANYVNGEVPGSgnYYIATQGCLPgtindFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSkgettlygniqvinideiqgrlyvfrklhiehv
|..||||..... .  .  ..||.||.|.     || |.........|| ..|.|.|. || .|||.                                 
gsdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

SKKGRGHYVVQYQFKVWPDHGVPQDPShMLDLMDDVNRKALEiqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEynkfEYEIDVQGSVQMLRHHRS
 ..   ....||..  ||||||| ..  .|.... |..  .|      . ||..|||||||||||| .. ... ....    |  .|.   |..|| .|.
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrp

GMVQTEDQYRFLYY
|||||..|||||||
gmvqtpsQyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 287-514 5.2e-51 169.2 In-house 4-234 (272) alignment 
Range on Protein: 287-514
Range on HMM: 4-234/272.0
NTYINANYVNGEvpGS---GNYYIATQGCLPGTINDFWSMvWQEDSKIIVMITNEIERGKNKCARYWP-----------SKGETTLYGNIQVINIDEIQG
..||||..|.|   |.    .......|.|| |..||| . .... | ||....| |||..|| ||||           .  .| |||.. |... |.. 
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

RLYVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGVPQDPshMLDLMDDVNRkaleiqqrgehFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNkfeYEID
  |. |.| ...... | .. | ....  ||||||||..  .|.|.. ...            ||..||||||..||||.......   ....     .|
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsle...tivd

--------VQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAYIERRQSLNEA
        ... |..|| .| |.||||.||.||| |....... .| ...
dYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvrae
0051082 (Phosphotyrosine protein) phosphatases II 287-501 1.8e-32 107.4 In-house 3-149 (151) alignment 
Range on Protein: 287-501
Range on HMM: 3-149/151.0
NTYINANYVNGEvpgsgnyYIATQGCLPgtinDFWSMVWQEDSKIIVMITNEIERGknKCARYWPSKGettlygniqvinideiqgrlyvfrklhiehvs
..|||..|| |        .....| |.    ||. ...... | ||....| |||  .|..|.|. |                                
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

kkgrgHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRkaleiqqrgEHFGPMIVHCSAGVGRTGTYIVVDIITKMmeynkfeyeIDVQGSVQMLRHHRSG
     . |.....  |||.|.|. .  .|.... ...            ||..||||||.||||| ......  .         ....  ....| .| |
.....ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpg

MVQTEDQYRFLYYAI
.||...|..|...|.
vvqpnqqflfqlfal
0049260 (Phosphotyrosine protein) phosphatases II 302-499 1.4e-39 130.5 In-house 7-144 (152) alignment 
Range on Protein: 302-499
Range on HMM: 7-144/152.0
SGNYYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWpskgettlygniqvinideiqgrlyvfrklhiehvskkgrghyvvQYQFKV
 ....|||||..| |..||| |... . ..|||.|.. |.|| ||..|.                                             ||..  
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlp

WPDHGVPQDPSHMLDLMDDVNRKaleiqqR---GehfGPMIVHCSAGVGRTGTYIVVDIITkmmeynkfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLY
|||||||... ..|.|.. ...       .   |   || .||||||||||||... ...          . ....  |...| .|.|.|....|.||||
wpDhgvpdlsqlllflllfiekl......aldkg...gpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

Y
.
e
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 305-498 6.6e-21 69.4 In-house 5-196 (198) alignment 
Range on Protein: 305-498
Range on HMM: 5-196/198.0
YYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSK-GETTLYGNIQVINIDEIQGRLYVFRKLHI-EHVSKKGRGHYVVQYQFKVW
 |||||  |  |. ||| |||.  |  |||. ..    .   . |||.    |. ||.. |          |.   | . . ..       . .|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPQDpshMLDLMDDVNRKALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEyEIDVQGSVQMLRHHRSGMVQTEDQYRFLY
 ..  |.     | .   |  . .  .   |.  |.||||| | | || .. .||  .  |  |    .|.    . ||  | |.. . ..| |.|
kekttpnv...alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskts.vvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 305-498 7e-21 69.3 In-house 6-197 (199) alignment 
Range on Protein: 305-498
Range on HMM: 6-197/199.0
YYIATQGCLPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSK-GETTLYGNIQVINIDEIQGRLYVFRKLHI-EHVSKKGRGHYVVQYQFKVW
 |||||  |  |. ||| |||.  |  |||. ..    .   . |||.    |. ||.. |          |.   | . . ..       . .|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPQDpshMLDLMDDVNRKALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEyEIDVQGSVQMLRHHRSGMVQTEDQYRFLY
 ..  |.     | .   |  . .  .   |.  |.||||| | | || .. .||  .  |  |    .|.    . ||  | |.. . ..| |.|
kekttpnv...alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskts.vvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 308-505 1.8e-21 71.4 In-house 39-221 (255) alignment 
Range on Protein: 308-505
Range on HMM: 39-221/255.0
AtqgclpgTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPS-KGETTLYGNIQVINIDEIQGRlyVFRKLHI-EHVSKKGRGHYVVQYQFKVWPDH
        |.. |. .. | ... .||...  | |..|| .|.|  | |   . ...|.  . ..    |.| |.|  ....| . | |  |..| |...
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadv..vlrtleitstlgekkkthtvkhysykGWiek

GVPQDPSHMLDLMDDVnRKAlEiqqrgehfgPMIVHCSAGVGRTGTYIVVDIITK-MM-EYNKF-EYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIK
  |...  .| ..  | |..           ...||||.|.||. ........ . |.   ..    |.|    .. ||..|.. ..|  |  |  . . 
naPelareilnilkvv.rds.k.........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

AYI
 ..
dlv
subfamily_hpo-7_pd Subfamily hpo-7 313-503 1.2e-19 65.3 In-house 43-225 (263) alignment 
Range on Protein: 313-503
Range on HMM: 43-225/263.0
LPGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPS-KGETTLYGNIQVINIDEIQgrLYVFRKLHIE-HVSKKGRGHYVVQYQFKVWPDHGVPQD
|  ||. |.... |  .. .||...  | |..|| .|.|  | |   . |..|   . ..    . . |..   ...| . | | .|..| |...  |..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PSHMLDLMDdVNRKALeiqqrgehfgPMIVHCSAGVGRTGTYIVVDIITK-MM-EYNKF-EYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKA
.  .| ... |.|.            ...||||.|.||.  . |.... . |.   ..    |.|    .. ||..|.. ..|  |  |  . .  
areilnilk.varnsk..........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 316-504 1.2e-18 61.6 In-house 103-288 (302) alignment 
Range on Protein: 316-504
Range on HMM: 103-288/302.0
TINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETT-LYGNIQVINIDeIQGRLYVF--------RKLHIEHVSKKGRGHY-VVQYQFKVWPDH
|.. .|... | .  |.| ... .| ...||| |.  | . .  .|.  |  .. ..  |  |         .. |.   || . .. |   .|  ||||
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvs.vktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPQDPSHMLDLMddvnrkaleiqQRGEHF-GPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVqgsVQMLRHHRSGMVQTEDQYRFLYYAI-KA
| |... . ||..           .  | .   ..|||||||||||| . .    ..   .|    ...   |. .|. | | ||.|.|  .|   . |.
Gapkeaytaldil...........kfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi...vlpvrqcryGavqdeqqliylllcvtkg

Y
 
l
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 338-489 9.4e-08 25.9 In-house 142-286 (332) alignment 
Range on Protein: 338-489
Range on HMM: 142-286/332.0
EIERGKNKCARYWPSKGETTLYGNIQVINIDEIQGrlyVFRKLHIEHVSKKGRGHYVVQYQFKVWPDHGvpQDPSHMLDLMDDVNRKALEI-QQRGEHFG
| |   . | ..|| |.    .  . .   |.       . |     |..| . |  |  .|  | |    . | .|||.   .. . .   .. |   |
ecelkakicrkfwpekrskkdfpalsiqasddhse...thmktfnltvtekkqdhqtvlmhfyewadas..klpeymldmrasiklqyirsskktgvcig

PMIVHCSAGVGRTGTYIVVDIITKMMEYnkfEYEIDVQGSVQMLRHHRSGMVQ
|... |..|| .   .  .|||   .     |. . .. ..  .. .| | ..
pimlvcatgvekcaisatidiivsrite...ehrvgfketmsaikmqrfgcfr
0048076 (Phosphotyrosine protein) phosphatases II 374-503 2.1e-25 84.5 In-house 22-141 (145) alignment 
Range on Protein: 374-503
Range on HMM: 22-141/145.0
LYVFRKLHIEH-----VSKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEiqqrGehfGPMIVHCSAGVGRTGTYIVVDIITKmmeynkfe
|  ...|.| .       ...  ....||..  |||||||......|.... ...   |    |   ||..||||||||||||... ... .        
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke....g...gpvlVHCsaGvgRtgtlvaaylmll........

YEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKA
. ....  ....| .|.|.|....|.||||.... 
lgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 376-499 2.3e-24 81.2 In-house 24-139 (144) alignment 
Range on Protein: 376-499
Range on HMM: 24-139/144.0
VFRKLHIEHV-------SKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKaleiQQRGehfGPMIVHCSAGVGRTGTYIVVDIITkmmeynkfE
 ..||.| .|        .   .....||..  |||||||......|.... ...     ...|   ||..||||||||||||... ...         .
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea....leeg...gpvlVHCsaGvgRtgtlvaaylmk........k

YEIDVQGSVQMLRHHRSGMVQTEDQYRFLYY
. ....  ....| .|.|.|....|.|||..
lglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 392-506 1.5e-13 44.8 In-house 218-345 (349) alignment 
Range on Protein: 392-506
Range on HMM: 218-345/349.0
HYVVQYQFKVWPDHGVPQDPSHMLDLMDdVNRK-----ALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMM-----EYNKFEYEIDVQ----GSV
. ..| |.| |.| ..  .|  .|  .. |  .       .     ..  ...|||||| ||||... .|..  ..     |.|| ...   .     .|
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

QMLRHHRSGMVQTEDQYRFLYYAIKAYIE
  ||  |  |||   |. ..| |.  |. 
nelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 393-506 6.8e-19 62.8 In-house 216-345 (350) alignment 
Range on Protein: 393-506
Range on HMM: 216-345/350.0
YVVQYQFKVWPDHGVPQDPSHMLDLMD----DVNRKALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVDIITK---MM-----EYNKFEYEIDVQG----S
 | | |.| |.| ..  .|  .|  ..     ..    |     ..  |..||||||||||||.. .| . .   ..     |..| ..   ..      
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VQMLRHHRSGMVQTEDQYRFLYYAIKAYIE
|. ||. |  |||. ||. |.| |.. | .
vnelrkqrismvqnldqfifiYeallfyfa
PTPc_DSPc_SM00012 394-502 3.4e-32 106.1 In-house 2-104 (105) alignment 
Range on Protein: 394-502
Range on HMM: 2-104/105.0
VVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQQrgehFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeYEIDVQGSVQMLRHHRSGMVQTEDQ
| .|... |||||||......|.|...|...  ....     .|..||||||||||||....||. ...|...  .|.|..  |..||..|.||||||.|
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeq

YRFLYYAIK
| ||| |..
ylflyrall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-501 4.4e-18 59.8 In-house 91-190 (440) alignment 
Range on Protein: 394-501
Range on HMM: 91-190/440.0
VVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKaleiQQRgEHFGPMIVHCSAGVGRTGTYIVVDIITKMmeyNKFEYEIDVQGSVQMLRHHRSGMVQTEDQ
. ||... |||.|||.  . .| ...|||      |..    ||..||||||.||||  |.|| | .     |   .||.   .. .|  |  |||| .|
lkqyhyqgwpdkgvpkfagpvlkmiqdvnes....qek.agngpllvhcsagagrtgviiavdsilre...akrsdqidifsfinsmrnnrpqmvqtpeq

YRFLYYAI
| |.. |.
yafvheav
0038934 (Phosphotyrosine protein) phosphatases II 394-504 4.6e-10 34.9 In-house 79-176 (194) alignment 
Range on Protein: 394-504
Range on HMM: 79-176/194.0
VVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQQrgehfGPMIVHCSAGVGRTGTYIVVDIITKmmeynkfeYEIDVQGSVQMLRHHRSGMVQTEDQ
 ..|    .||.|.. . . .|. .| |...  | ..     |   ||| ||.||||| ..  .| .        . .... .....|  | |.... |.
gieylklpfpddgtvPsleillrfldlvdeflnedpg.....gvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdy

YRFLYYAIKAY
.. |.   | .
leallkrykel
subfamily_PTPDC1_pd Subfamily PTPDC1 396-498 1.8e-07 25.8 In-house 85-169 (182) alignment 
Range on Protein: 396-498
Range on HMM: 85-169/182.0
QYQFkVWPDHGVPQdPSHMLDLMDdVNRKALEIQQrgehfgpMIVHCSAGVGRTGTYIVVDIItkmmeynkFEYEIDVQGSVQMLRHHRSGMVQTEDQYR
 |.|  |.|.||.    ..||..  |   ||. ..       . ||| || ||||  | . ..        .  ... . .....|..|.  .|| .| .
vynf.gwkDygvas.leriLdivk.vvafalqegk.......vavhChaGlGrtGvliacylv........yakrltaekaiklvrskrpksiqtreqve

FLY
.. 
lvk
PTPc_motif_SM00404 404-491 2.4e-06 22.5 In-house 49-128 (140) alignment 
Range on Protein: 404-491
Range on HMM: 49-128/140.0
DHGVPQDPSHMLDLMDDVNRKALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVdiitKMMEYNKfeyeIDVQGSVQMLRHHRSGMVQTE
   .|.| ..  .| .. .. .  |..  .  |  .||| ||| |..| |..     .|.|..    .... ....... |. . ...
ilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia....Ylmryrq....lslaeayefvkerRpiispnl
DSPc Dual specificity phosphatase, catalytic domain 406-497 5.7e-06 21.2 Pfam-A 44-127 (133) alignment 
Range on Protein: 406-497
Range on HMM: 44-127/133.0
GVPQDPSHMLDLMDDVNRKALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVdiitKMMEYNKFeyeiDVQGSVQMLRHHRSGMVQTEDQYRFL
..|.. ..  .. .. ..    |..  .  .  .||| ||. |..| |..     .|.....    ...  .....  || ..... . | |
ripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia....Ylmktknl....slneAyefvkerrskispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 406-497 5.7e-06 21.2 In-house 44-127 (133) alignment 
Range on Protein: 406-497
Range on HMM: 44-127/133.0
GVPQDPSHMLDLMDDVNRKALEIQQRGEHFGPMIVHCSAGVGRTGTYIVVdiitKMMEYNKFeyeiDVQGSVQMLRHHRSGMVQTEDQYRFL
..|.. ..  .. .. ..    |..  .  .  .||| ||. |..| |..     .|.....    ...  .....  || ..... . | |
ripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia....Ylmktknl....slneAyefvkerrskispnagflrqL
subfamily_CDC14_pd Subfamily CDC14 426-498 4e-07 24.2 In-house 256-317 (328) alignment 
Range on Protein: 426-498
Range on HMM: 256-317/328.0
LEIQQRGehFGPMIVHCSAGVGRTGTYIVVDIITkmmeynkfEYEIDVQGSVQMLRHHRSGMVQTEdQYRFLY
||| ..    | ..||| ||.||||| | . ..         .|..  . ..  ||  | |.| .  | .||.
leiaeka..eGaiavhCkaGLGrtGtLiacylmk........hyrftaaeaiawlricrPGsvigp.qqkfle
subfamily_CG42327_pd Subfamily CG42327 432-504 2.2e-16 54.4 In-house 244-314 (319) alignment 
Range on Protein: 432-504
Range on HMM: 244-314/319.0
GEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKfeYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY
 |..||..|||| ||||||. |  ||  . .| .|    .|.   |. .|. |.  |.| .|| |.|  .  |
resqGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 437-502 1.3e-11 39.0 In-house 230-292 (297) alignment 
Range on Protein: 437-502
Range on HMM: 230-292/297.0
PMIVHCSAGVGRTGTYIVVDIITKMMeynKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIK
...|||||||||.|  .  |.| ...   . ..  ||.  ...||. |. .||| .|. .|| |. 
yllvhcsaGvGrsGvvvlsdvilakl...rkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_PTEN_pd Subfamily PTEN 437-504 1.2e-06 23.6 In-house 116-179 (184) alignment 
Range on Protein: 437-504
Range on HMM: 116-179/184.0
PMIVHCSAGVGRTGTYIVVdiitKMMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAIKAY
 ..||| || ||||. ||      .......| . ..    .  | . .  |.   | |...|  | .
vvvvHCkaGkGRtGvliva....yllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekll
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 438-501 5.2e-11 36.8 In-house 1-61 (69) alignment 
Range on Protein: 438-501
Range on HMM: 1-61/69.0
MIVHCSAGVGRTGTYIVvdIITKmMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
|.||||.| |||||.|   |. . |   | |  .|.   || .|  |  ||  | .| |.. |.
mvvhcssgtgrtgtfia..imve.marikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 439-501 9.9e-11 35.8 In-house 1-60 (69) alignment 
Range on Protein: 439-501
Range on HMM: 1-60/69.0
IVHCSAGVGRTGTYIVvdIITKmMEYNKFEYEIDVQGSVQMLRHHRSGMVQTEDQYRFLYYAI
.||||.| |||||.|   |. . |   | |  .|.   || .|  |  ||  |..| |.. |.
vvhcssGtGrtGtfia..imve.marikseklvdifnnvqymrkcrpmmvmneneymfihdal