Gene PTPN6-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP054_AA protein Get Run
AqueP054_AA_103-385 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 8-82 1.9e-19 60.1 Pfam-A 1-77 (77) alignment 
Range on Protein: 8-82
Range on HMM: 1-77/77.0
WFHPNLSGFEAEELLKG-TVNGSFLFRPSQSSPRDCTLSIKTEGGVTHVRIKKNETG-YHLFPDEVFPNLNSFVHHY
|.| ..|. |||.||.    .|.|| |.|.|.| | |||....| |.|.||...|.| | .. .| | .|.  |.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
0050432 (Phosphotyrosine protein) phosphatases II 93-385 1.9e-77 255.9 In-house 19-300 (308) alignment 
Range on Protein: 93-385
Range on HMM: 19-300/308.0
TLVHLLSPVLHNNEGHLPRegeVKDHLNLEQDFEELPSYLYSQD--KGNKIQNIHKNRYNASIPFDDNVISLkepSvYGSTYINASPIKTAStGGLQAQY
.||. |   ...   .| .    .|  .||. ||||.|.  . .   ... .|..||||   .|.| . . |   .  ||.||||| ... |  .|. ..
ilvsslklsvldllkllek...aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...d.egsdYInAsyvdgys.sklprkf

IATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEI-PEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVG
|||||||..|. ||||.||......|.|||.||| |   | .|||. .    . .||. .  |.|..||.||.|.. |.. ..||.| | |||. .|| .
IatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdh

SVPRSTGAFLDYWKEINAKTketSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKgnnVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
.|| |. ..||...... .    .. |..|||..|.||||.|||.| ||.| | .       .  .|  ||.||||||||  ||...|..| .| |
gvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_PTPN6_pd Subfamily PTPN6 95-388 5.9e-113 371.9 In-house 2-301 (306) alignment 
Range on Protein: 95-388
Range on HMM: 2-301/306.0
VHLLSPVLHNNEGHLPREGEVKDHLNLEQDFEEL----PSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTASTGGLqAQY
..||.  ..... .| .|.| ... ..|..||||     ..|.|...|.|..| .||||....|||.....||||||.||.||||. ||....|   ..|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksy

IATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVlHGKILISSLEETTLDYYTMRHFLLSH-EEKGEERNVFHFHFRDWPVG
||||| |.||.|||||.||||.|..|.|.|. || |...|.||||..|  |  .||| .....|..|..|..|....|. ..|.|||.||..||..||  
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdh

SVPRSTGAFLDYWKEINAKTKETS---SRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
.||...||.||.....|.|..|..   ..|..|||..||||||.|| || ||.. | ||...  ... ||.|.|.|| |.|||. ||...|....|| ..
gvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

DR
..
kk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-240 9.6e-21 68.9 In-house 16-156 (350) alignment 
Range on Protein: 109-240
Range on HMM: 16-156/350.0
LPREGEVKDHLNLEQDFEeLPSYLYSqdKGNKIQNIHKNRYNASIPFDDNVISLK---------EPSVYGSTYINASPIKTASTGG-LQA--QYIATQGP
... ..|| .| || | |  ||  .     . ..   ||||.  .|.. . . ||         . |. .. ||||. .| .  .   ..  .|||||.|
itknstvksrlsLesdse.spsnDvi..lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaP

LDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIP
|  |. ||.... . . ..|..||..|||.   | |||.  .. 
lpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsyd
0039614 (Phosphotyrosine protein) phosphatases II 114-385 3.2e-72 238.8 In-house 27-290 (297) alignment 
Range on Protein: 114-385
Range on HMM: 27-290/297.0
EVKDHLNLEQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISL--KEPSVYGSTYINASPIktaSTGGL-QAQYIATQGPLDTTISDFWRLVWQ
  ..   |...||||.|.  ..  .....|..||||   .|.|.. . |  .. .. .|.||||| .   ..  | . ..|||||||. |. ||||.||.
kansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv...dgydlltrkfIatqgPlpetvedFwrmvwe

EQSTIIIMLTELVELGEsMCTRYWPTVEIpevLHGKILISSLEETTLDYYTMRHFLLSHeeKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTK
...|.|.|||.|||||  .| .|||. .     .|.. .  |....||.||.|.. ...  .||.| | ||.. .|| ..|| |.  .|.  ....   .
qgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreala

ET-SSRPMIVHCNDGIGRTGAFIAIDSLLRQKEV----KgnnvlgeMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
|. ...|..|||..|.||||.|||.. .|.| |             ..  |. ||.||||.|||  |||..|..| .. |
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.......vleavkelreqRpgavqtpsqyrflydallellk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 114-383 5.3e-62 204.7 In-house 17-282 (305) alignment 
Range on Protein: 114-383
Range on HMM: 17-282/305.0
EVKDHLNLEQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYG-STYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
.|..  .||.....|..   | | |.| .| .|||... ...||. | |.| .  . | ||||| ... .    . .||..||||..|..|||||...|.
rvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr...kkkyivaqgPlkntvadfWrliveek

STIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSH-EEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKE
 . |.|||.||| |.. | .|||. .  .. .|.. .   .|.|   |..|.. .|  .|. |.|.| .... |||   ||......|.  |... . |.
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

TSSRPMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKY
    |..|||..|.||||.|||.|  | .  .|  .|.  ..| .  ||..|..||||  || .....|...
dkgvpllVhCsagvgRtGvfiavdialer..lkkEevvdvfev.lkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPRB_pd Subfamily PTPRB 115-385 3.9e-68 224.6 In-house 21-286 (293) alignment 
Range on Protein: 115-385
Range on HMM: 21-286/293.0
VKDHLNLEQDFEELPSYLY--SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQE
 ...|.. ...||| .     .... .. .|  ||||.  .|.| . . |..  .  || ||||. |.  ..   . ..||||||| .|. ||||.||..
adsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns...prefiatqGPlpetvddfWrmvwek

QSTIIIMLTELVELGESMCTRYWPTVEIPEvLHGKILISSLEETTLDYYTMRHFLLSHeeKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKT-K
.|.||.|||.||| |   | .|||. | |  |.|.| .. ..|..|. ...|......  . |||.| ..||  ||   || .| ..||...... .. |
kssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

ETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVkgNNVLGEMkVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
..|.||..|||  |.||||.|||.| ||.. |   ....  .  .| .||..|  .|||  || .|.|.. .. .
taskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdif.givaelReeRnllvqtekqYifihqcvldllr
subfamily_eak_pd Subfamily eak 115-386 6.1e-23 75.7 In-house 25-307 (332) alignment 
Range on Protein: 115-386
Range on HMM: 25-307/332.0
VKDHLNLEQDFEELPsYLYSQDKGNKIQNIHKNRYNaSIPFDDNVISLKEPSVYGSTYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQST
.....|. .|...    | |. ..........| ..  .|.| . . |         ||||| .. .  |    .|| |  . .. .  ||..| ...| 
inqrinivadlddyq.rllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevG...rkyiltGiasedkvfafwqmvleqksp

IIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEkgEERNVFHFHFRDWPVGSVPRSTG--AFLDYWKEINAK----
 |..| | |||.     .|.|     |. .|.. .   |    . . .| . ||  .  |  .|.|...  |   ..|.     |. .  ||. .     
aivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpkyedflalrkvmkevGvllliv

--TKET-----------SSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGeMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
  ..              |   |. .  |  |.|.|. || |.|  . | .|.   .. |.   ...|   | .|||. .||... .| ..
mksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlys.vedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_PTPRD_pd Subfamily PTPRD 116-424 1.2e-80 266.8 In-house 20-320 (564) alignment 
Range on Protein: 116-424
Range on HMM: 20-320/564.0
KDHLNLEQDFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQS
...|..|...... .    . .. || .| .||||.  ...| . . | | . . || ||||| |..  .   . .|||||||| .||.||||.||...|
nsdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrk...rkayIAtqgPlaetiedFWRmvweqns

TIIIMLTELVELGESMCTRYWPTVEipEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTkETS
..|.|||.|.| |.  | .|||. .  .  .|.. ..  ||..| .|..|.| |..... | |.| .||| .||   || |. ..|| .....| . |. 
stiVmltkleEkgkvkchkYWPekg..tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epd

SRPMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKNDRNGRPPMKIVESLRKVEDSESGKKVS
. |..|||. |.||||.||.||..|..  .| .... ..   |. |||||. ||||  || .|.... .. .   .  .  .. . |.|..  |......
agPivVhCSaGVGRTGtfividamler..ikeektv.DiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemt

PLLRNiYRRMS
 | .. ..|..
glele.FqrLa
0051299 (Phosphotyrosine protein) phosphatases II 116-383 2.6e-74 245.6 In-house 20-285 (288) alignment 
Range on Protein: 116-383
Range on HMM: 20-285/288.0
KDHLNLEQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQ
..  .|.. ||||.|.|  ...  ... .|..||||   .|.|.. . |.  ..| ||.||||| |   ..  |. ..|||||||..|..||||.||...
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi...dgynlkrkfIatqgPlpntvedFWrmvweqn

STIIIMLTELVELGESMCTRYWPTveIPEVLHGKILISSLEETTLDYYTMRHFLLSHE----EKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAK
...|.|||.|||||   | .|||.     . .|.| .  |.|..||.||.|.. ...      .||.|.| |||. .||  .|| |. ..||...... .
vrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

TKeTSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGnnvLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
 .  .. |..|||..|.||||.|||.| ||.| | .|     ..  .|. ||.||||||||  |||..|..|  |
la.sgggpvvVHCsaGvgRtgtfialdllleqlekeg...gvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_PTPRA_pd Subfamily PTPRA 116-383 4.7e-61 201.5 In-house 29-294 (330) alignment 
Range on Protein: 116-383
Range on HMM: 29-294/330.0
KDHLNLEQDFEELPS--YLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
 |   . ..|. ||.     . .  .| .| .|||.   .|.| . . | .   |  | ||||| |.       . ..||.|||.. |. ||||..|. .
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke...kdkfiaaqGPkeetvedfwrmiweqk

STIIIMLTELVELGESMCTRYWPTVEIpeVLHGKILISSLEETTLDYYTMRHFLLS----HEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAK
|. |.||||| |  |. |..|||.  .  | .|.| ..  .|| |  ||.|.||.     . .. ..| |  |||. ||   ||  .   |.. |.....
sativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl

TKETSSrPMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLGEMKvLVESLRKQRPGMVQTALQYRYIYQVLEKY
 . ... |..|||  |.||||.||..|..| .  || ....   .  |..||.||| ||||  || .||.|| .|
nqqsag.pivvhcsaGvGrtGtfivldavler..vkaerkvdvfe.fvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRN_pd Subfamily PTPRN 116-380 5.5e-55 181.2 In-house 26-288 (297) alignment 
Range on Protein: 116-380
Range on HMM: 26-288/297.0
KDHLNLEQDFEELPSYLY---SQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTAStgGLQAQYIATQGPLDTTISDFWRLVWQE
|.. .||...| | .|     ... ... .|..|||..| .|.|.. ..|||  |   | |||||.|        .. |||||||| .|..|||..||..
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd..prapayiatqgplastvadfwqmvweq

QSTIIIMLTELVELGESMCTRYWPTvEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKE
 ...|..||.| | | . |.||||  |  || |   .    |    | | .| | |   .. | | |  |||  ||  .|| |. ..|.. . .|   . 
Gvvvivnltrleeegvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG

tSSRPMIVHCNDGIGRTGAFIAIDSLLrQKEVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
  | |..||| || ||||..|.|| .| .. .|| . . ..   .| || ||||.|.|  |........
.rscpivvhcsdGaGrtGvyilidlvl.nrllkGvkei.diaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 116-382 2.3e-15 51.0 In-house 18-277 (303) alignment 
Range on Protein: 116-382
Range on HMM: 18-277/303.0
KDHLNL-EQDFEELPSYLYSQ-DKGNKIQNIHKNRYNASIPFDDNVISLKEpsvygSTYINASPIKTAStgglQAQYIATQGPLDTTISDFWRLVWQEQS
..  |.  ..||.. |||  .  | . ..|..|||.   | .|   . | .     |.|| || ..  |    . . | || ||  | .|||... ... 
dedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd.....ssyihasylelds....skkailtqlplshtaadfwqmiieqkv

TIIIMLTELVELGESMCTRYWPT-VEIPEVLHGKILISSLEETTL-DYYTMRHFLLSheeKGEERNVFHF-HFRDWPVGSVPRS-TGAFL-DYWKEINAK
  ...|    |  .      .|   .. .  .  | .  . .  | | ....   .|   .|. .  .|  |...|| .|.|   .  |. . |.     
kcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvs...ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvl

TKETSSRPMIVHCNDGIGRTGAFIAIDSLLRqkEVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEK
 | . |.| .     | ||.|.|  ...      .. ..   ..   .| .|. |   ||   |. ..| .| .
rkysdstptvymslsgcgragtfalfetahl..slhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
0047943 (Phosphotyrosine protein) phosphatases II 117-383 2e-73 242.5 In-house 10-271 (273) alignment 
Range on Protein: 117-383
Range on HMM: 10-271/273.0
DHLNLEQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLkepSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQST
.   |.. ||.|.|.   ..   .....|..||||   .|.|.. . |   .  || ||||| .   ..  |. ..|||||||. |. ||||.||.....
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv...dgynlkrkfiatqgPlpntvedfwrmvweqnvr

IIIMLTELVELGESMCTRYWPTVEIP-EVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKET-
.|.|||||||||   | .|||. .   .. .||. .  |.|.| |.||.|.. |.. . ||.| | |||. .||  .|| |.  .|....... . ... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

SSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVlgeMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
|. |..|||..|.||||.|||.| ||.| | .|.     .. .|  ||.||||||||  |||..|..| .|
sngpvvVHCsaGvgRtgtfialdllldqlekeggvd...vleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPN23_pd Subfamily PTPN23 117-383 2.5e-54 179.0 In-house 13-279 (288) alignment 
Range on Protein: 117-383
Range on HMM: 13-279/288.0
DHLNLEQDFEELPSYLYSQDKGNKI----QNIHKNRYNASIPFDDNVISLKepsVYGSTYINASPIKTASTGGlqAQYIATQGPLDTTISDFWRLVWQEQ
.. .|.. |.|| ..   . ... |     . .|||..  .|.| | . |.        ||||| .|  |.|    ..||||.||..|..|||..|....
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgc..PdfiatqaPlqstlnDFWlmvyeqk

STIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINA---KT
| .|.||..  |||.  . ||||. .   | .|.. ..  ........  |.. |..... . ..| | ..  ||   || | . .|.. .|...   ..
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

KETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKevKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.. |  |..|||  |.||||.|  . . .|.   . .| | ..  .|. ||.||  |||.  |..  |..  ..
qrksktPlvvhCsaGvgRtgvfalvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 117-227 7.4e-06 19.6 In-house 24-132 (302) alignment 
Range on Protein: 117-227
Range on HMM: 24-132/302.0
DHLNLEQDFEELPSYLYSQDKGNKI-QNIHKNRYNASIPFDDNVISLKEPSvygSTYINASPIKTASTGglqAQYIATQGPL-DTT--ISDFWRLVWQEQ
|. .....|... .   . .| .   .|..||. .     |.|.. |..       |.||| ..  . .    . | .| |  |..  . .|||.|.||.
dtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPelt...rsiilaQlpkvdsedsveeFWrmvfqek

STIIIMLTELVELGE
 . . .|    || .
ivsvvilvgeeelkk
0045450 (Phosphotyrosine protein) phosphatases II 118-383 3.3e-72 239.1 In-house 26-303 (307) alignment 
Range on Protein: 118-383
Range on HMM: 26-303/307.0
HLNLEQDFEELPSYLY----SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV--YGSTYINASPIKTA-----STGGLQAQYIATQGPLDTTISDFWR
   |.. ||.|.|.      . . ... .|..||||   .|.|.. . |. ..    .| ||||| ...      ..  |. ..|||||||. |. ||||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LVWQEQSTIIIMLTELVELGESMCTRYWPTVeIPEVLHGKILISSLEETTLDYYTMRHFLLSHE-EKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEI
..|....|.|.|||||||||  .| .|||.    |. .|.. .  |.|..||.||.|.. ...  ..||.| | |||. .|| ..|| |.  .|| ..|.
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

NAKTKET-SSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
..  .|. .. |..|||..|.||||.|||.. .||| |  |      .   |. ||.||||.||.  |||..|..| ..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 118-384 8.7e-70 230.0 In-house 20-279 (288) alignment 
Range on Protein: 118-384
Range on HMM: 20-279/288.0
HLNLEQDFEELPSY--LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQST
. ....... |..     |...|.. .| .||||.  .|.| . . ||. . . |. ||||| |.       . .||||||||  |. |||.||......
rtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk...kkkyiatqgPladtvndfWelvyenkts

IIIMLTELVELGESMCTRYWPTVEIPeVLHGKILISSLEETTLDYYTMRHFLLSheEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETsS
 |.||||||| |.. | .|||. . | ...|.. .  .|. .|. ...|..||    |..|... ....  ||  .||.|.  .|.. . ..   ..  .
tivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

RPMIVHCNDGIGRTGAFIAIDSLLRQKEVkgNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
 |.|||| .|.|||| |||.| |. . |   .... ..   |. |||||. .|||  || .||.|| .  
gpiivhCsaGvGrtgtFialdalidavee..edyi.DvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 118-386 2.1e-67 222.4 In-house 19-282 (318) alignment 
Range on Protein: 118-386
Range on HMM: 19-282/318.0
HLNLEQDFEEL--PSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQST
.|.|....|.|   .   .. | ..  | .||||.  ...|.  . |..  .. || ||||. |        . .|||.|.||  ||.||||.||. .|.
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrr...kkayiaaqaPlpetieDfWrmvWeqnsa

IIIMLTELVELGESMCTRYWPTVEipEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSS
.|.|||...| |   . ||||  .     .||. .   ||..|..|..|.| ....|. |.|.|  .|. .||  .|| |.. .||  .....  .... 
vivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga

RPMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
.|..|||  |.|||| |||.|.||..  .| .... ..   |. ||.||. ||||  || .||.|| .. . 
gpivvhCsaGvGrtGvfiavdiller..ikaealv.Dvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-386 2.5e-62 205.4 In-house 4-270 (274) alignment 
Range on Protein: 118-386
Range on HMM: 4-270/274.0
HLNLEQDFEELPSYLySQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY--GSTYINASPIKTAStgGLQAQYIATQGPLDTTISDFWRLVWQEQSTI
  .||..| |||.   .|.. .   . .||||.. .| .   ..|.. |.    |.||||  ||  .  . .  |.|||||| .|..||||...||....
fkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyd..eeskayvatqGPlpntvadfWrmiyqeevqv

IIMLTELVELGESMCTRYWPTVEIP--EVLHGKILISSLEETTLDYYTMRHFLLSHEEKgeERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETS
|.|||.| |  |. |..|.|. |    .  .|.. |   . .. . |..|...|.. |.  ||.| |. . |||   .|... ..||  .|.. . .|..
ivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeen

SR--PMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
 .  |..|||  ||||||.||||.  .||  .. ..|.  .|. |  || .| |||||. ||..|...| .|.|.
aklapvvvhCsaGiGrtGcfiaisiavrq..lreeivvdvlki.vcnlrldrGGmvqtseqyelihralclylkr
0040438 (Phosphotyrosine protein) phosphatases II 119-386 1.5e-71 236.7 In-house 18-278 (317) alignment 
Range on Protein: 119-386
Range on HMM: 18-278/317.0
LNLEQDFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTII
  |.. ||.|.|.  .. . ... .|..||||   .|.|.. . |.  .....|.||||| .   ..  |. ..|||||||. |. ||||.||....|.|
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv...dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

IMLTELVELGESMCTRYWPTveIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKeTSSRP
.|||||.|||  .| .|||.    .. .|.. .  |.|..|...|.|.. ... ...|.| | |||. .|| ..|| |.  .||  ...... .  .. |
vmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggp

MIVHCNDGIGRTGAFIAIDSLLRQKEVKGnnvLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
..|||..|.||||.|||.. .|.| | .|      ..  |. ||.||||.|||  |||..|..| .| |.
vlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Ptp69D_pd Subfamily Ptp69D 119-385 2.2e-59 196.1 In-house 22-287 (307) alignment 
Range on Protein: 119-385
Range on HMM: 22-287/307.0
LNLEQDFEELP--SYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTI
  |....|.|.      |   ..|  |  ||||.. ..||.. . ||. .    |.||||| ||.      . ..|| |.|...|| ||||.... ..|.
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke...kkkfiaaqdPveatigDfWRmiaeqevtl

IIMLTELVELGESMCTRYWPTVeiPEVLHGKILISSLEETTLDYYTMRHFLLSHEE-----KGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTK
|.||..| |  .  | .|||     || .|.||.   .| . ..|..|.. .|. .       ..|.|  .|.  |.   ||... . |.. ....   |
ivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

ETsSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNvlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
     |..|||. | ||.| |.|.|||| | .   .    ..   |  ||.||. .||   || ..|. | .|..
ln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkv...difetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRG_pd Subfamily PTPRG 119-382 2.8e-56 185.9 In-house 19-285 (563) alignment 
Range on Protein: 119-382
Range on HMM: 19-285/563.0
LNLEQDFEELPSYLYSQ----DKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGS--TYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
  ....||.| |   |.    .. .| .| .||||   ...|   ..|.. .   .   ||||. |.       . ..||||||| .|. ||||..|...
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqk...skafiatqgplkdtfddFWrmiWeqn

STIIIMLTELVELGESMCTRYWPTvEIPEVlHGKILISSLEETTLDYYTMRHFLLSH---EEK---GEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEIN
..||.|.|.||| |   | .|||. . .|   |.. .   || .| .||.|.. . .   ..|    .|..| ..|. .||  .|| ..   | . |  .
vaiivmitnlvergrrkcdvYWPk.deset.ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkss

AKTKEtSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGN-NVLGEMKvlveSLRKQRPGMVQTALQYRYIYQVLEK
| .|.    |..|||. |.|||| .|..|.||.| . .   ||.| .|     .| ||. .|||  || .....| .
aanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflk....hiraqRnflvqteEqYiflhdalle
0046845 (Phosphotyrosine protein) phosphatases II 120-384 7.5e-77 253.8 In-house 1-274 (284) alignment 
Range on Protein: 120-384
Range on HMM: 1-274/284.0
NLEQDFEELPSYLY----SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV--YGSTYINASPIKTA--STGGLQAQYIATQGPLDTTISDFWRLVWQE
.||..||||.|. .    | . ... .|..||||   .|.|.. . || ..    .|.||||| ...   .    . ..|||||||..|. ||||.||..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

QSTIIIMLTELVELGESMCTRYWPTVeIPEVLHGKILISSLEETTLDYYTMRHFLLSHEE-KGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTK
....|.||||||| |  .| .|||.     . .|.. .  |.|.. |.||.|.. |.... .||.| | |||. .||  .|| |.  .|.......   .
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

E-TSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
.  .. |..||| .|.||||.|||.| ||.| | .| ..   .  .|  ||.||||||||  |||..|..|  | 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 120-384 9.3e-67 220.3 In-house 24-283 (319) alignment 
Range on Protein: 120-384
Range on HMM: 24-283/319.0
NLEQDFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIII
 ||..|..|      . |. .| .| .||||.  ...|   . |.| . | ||.||||| | .      . ..||||.||..||.||||.||.|.| |..
llekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe...rekfiatqaPlentiedfWrmvWeeessivv

MLTELVELGESMCTRYWPTVEIpeVLHGKILISSLEETTLDYYTMRHFLLSHEEK-GEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRP
|||.||| ..  . .|||. ..  .  |....  .||  |. | .|.. | .     | |.|.||.. .||   ||... . || .|.|.  ...|.|.|
mltklveklkvklkkywpeenf..eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

MIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
..||| .|.||||.||..|  | .  || ..|| ..   |  || ||. |||.  ||..||..| .. 
ivvhCsaGvGRtGtfivldamler..vkeegvl.DvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 121-383 2.1e-57 189.4 In-house 26-279 (315) alignment 
Range on Protein: 121-383
Range on HMM: 26-279/315.0
LEQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL--KEpSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIII
..||.| .|   |.  |  .||.| .||||   |..|   . |   |    .| |.||. |.  .    . .|||.|||. ... ||||||..|. . |.
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlplle.ndphsdyvnanfidGynk...krryiaaqgpnvasvkdfwrlvfeedigkiv

MLTELVELGESMCTRYWPTVeipEVLHGKILISSLEETTLDYYTMRHFllSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKtKETSSRPM
|||.|||  .... .|||     .|..||| ..  .|   . ||.| .  |   . . |.|. .|.  ||   ||..| ..... . ..   ...|  ..
mltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh.htnsvgai

IVHCNDGIGRTGAFIAIDSLLRQKEVKgnNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL-EKY
.|||..|.||||.||..|..| | |..  |.. ..  ... .|..| .|||.| ||..||..| | .
vvhcsaGvGrtGtfitldavldqaeae..nai.dvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 121-413 2.6e-54 179.2 In-house 21-306 (315) alignment 
Range on Protein: 121-413
Range on HMM: 21-306/315.0
LEQDFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIM
. ..| .||    | |  . . .| .||||.  .|.| . . |        | ||||| ||.  .   .  |||.||||.....||||.|.||. | |.|
fseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd...dkayiasqgPlkasvddfwrmvlqekvttivm

LTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFllSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKtKETSSRPMI
.|.. |     | .|||  .   |  |.| .. |.  .    ..|..     .  | |.|  |.|..||   |.. |...| . ||. |. ...   ...
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsll

VHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKNDRNGRPPMKIVESLRKVEDSESGKKVS
|||  |.|||| .|.||. . |  .| .... ..  .|. ||..|| .|||  .| .||... .. .      . ..... |. .  | .|.  |
vhcsaGvGrtGvvisidevvaq..ikrtrsv.dvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 121-383 1.7e-42 140.2 In-house 17-292 (301) alignment 
Range on Protein: 121-383
Range on HMM: 17-292/301.0
LEQDFEELPSYLYS-QDKGNKIQNIHKNRYNASIPFDDNVISLKEPS---VYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTII
.|....|| ..     . | . .| . ||..   ..||| | ||. .   .   .||||| |.  |    . ..||.|||.. |. |||||.|||. . |
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse...kkkfiaaqgpmkktlvdfWrliwqekpvsi

IMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMR-----------------HFLLSHEEkgEERNVFHFHFRDWPVGSVPRSTGAFL
.|.|.| |  .| |..|||. |  .   |.. .   .|...  ...|                 .|  ...   . ..|  ..  |||   | |     |
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvL

DYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKY
    ..  ...  .  |..||| |...|.| .....  | |  .| . |   ..| ....|...||.|.|  ||  ||.|...|
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ..ckaegVVdvfqv.tkavrrskpgaVtTLeqytsiydvidmy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 121-384 7e-34 112.0 In-house 8-259 (267) alignment 
Range on Protein: 121-384
Range on HMM: 8-259/267.0
LEQDFEELPSYLYSQDK---GNKIQNIHKNRYNASIPFDDNVISLKEPSVYgstYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSTIII
.|..||..      . .       .|  .||.. ..|.||... |..       ||||| ...  |.    ..|.||.||. ||.||. .. ... ..|.
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktk...nafivtqdplkntitdfltvihdqkvpviv

MLTELvelGESMCTRYWP-TVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKgeERNVFHFHFRDWPVGSvprSTGAFLDYWKEINAKTK-ETSSR
.||     ..    ..||  .   .  .   .  |||.   ||  .   |  ..|    .||  .... | . .       .|     | || . |  .|
lltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes..ahnvtlyyykkwnint...nnkpylkplfgilaknqlengnr

PMIVHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKYE
|..|.|.||.||.|.|. ||| |..  .| ..|.   .  .  .|.||.|.|.|  .| ||...| .| 
PlvvacsdGvGrsGtflvidsqler..aktegvsdifdf.lrkirsqriglvdtkeryiyihellaeya
0036941 (Phosphotyrosine protein) phosphatases II 122-395 9.8e-76 250.2 In-house 16-288 (297) alignment 
Range on Protein: 122-395
Range on HMM: 16-288/297.0
EQDFEELPSYLY--SQDKGNKIQNIHKNRYNASIPFDDNVISLkepSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIML
.. ||||...|.  | . ... .|..||||   .|.|.. . |   .  || ||||| .   .. .|. ..|||||||..|. ||||.||....|.|.||
lkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv...dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TELVELGESMCTRYWPTVEIPEVLHGKILISSLEETT--LDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKET-SSRP
|||||||  .| .|||. |  .. .|.. .  |....  ||.||.|.. ... ..||.| | |||. .||  .|| |.  .||...... . |.. |. |
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

MIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKNDRNGRPPMK
..|||..|.||.|.|||.| .|.| | |  .    .. .| .||.||||.|||  |||..|..| .. |. ..  |..|
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
DSPc_SM00195 122-383 4.6e-72 237.9 In-house 3-261 (263) alignment 
Range on Protein: 122-383
Range on HMM: 3-261/263.0
EQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIM
...||.| ..    . ....| .| .||||.  .|.|.. . ||..    ||.||||. ||.|     . .||||||||..|..||||.||.|...||.|
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLD-YYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETsSRPM
||| .| |.  |.||||  .  .  .||| .   |... .  ...|.. |..|.| |.|.| ......||  .|| ||  .|.. .... ..... | |.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

IVHCNDGIGRTGAFIAIDSLLRQKEVKGNnvlGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.||| .|.||||.|..||..|.. | . .    ... .|..|||||||||||  ||..||... .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 122-383 4.6e-72 237.9 In-house 3-261 (263) alignment 
Range on Protein: 122-383
Range on HMM: 3-261/263.0
EQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIM
...||.| ..    . ....| .| .||||.  .|.|.. . ||..    ||.||||. ||.|     . .||||||||..|..||||.||.|...||.|
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLD-YYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETsSRPM
||| .| |.  |.||||  .  .  .||| .   |... .  ...|.. |..|.| |.|.| ......||  .|| ||  .|.. .... ..... | |.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

IVHCNDGIGRTGAFIAIDSLLRQKEVKGNnvlGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.||| .|.||||.|..||..|.. | . .    ... .|..|||||||||||  ||..||... .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeailey
0045098 (Phosphotyrosine protein) phosphatases II 122-386 2.5e-66 219.2 In-house 12-274 (278) alignment 
Range on Protein: 122-386
Range on HMM: 12-274/278.0
EQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISlkepsvygsTYINASPIKTAstgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTE
| .|  |... ..   .... |..||||   .|.| . .           ||||| |..      . ..|||||||..|..||||..|....|.|.||||
efefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.....pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LVELGESMCTRYWPTveIPEVLHGKILISSLEETTLDYYTMRHFLLSHE----EKGEERNVFHFHFRDWPVGSVPRST--GAFLDYWKEINAKTK-----
|||||   | .|||      . .|.. .  |.|..||.||.|..|. .     | .|.|.|.|.|.  || ..|| ..    ||.....|..  |     
lvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

-------ETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKevkgNNVLGeMKVLVESLRKQRPG-MVQTALQYRYIYQVLEKYEKN
       . |. |..|||. |.||||...|.. .|..     ....  .   |. ||.|||| .||.  |||..|..| .. ..
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell....eggvd.lleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 122-413 1e-44 147.5 In-house 23-265 (392) alignment 
Range on Protein: 122-413
Range on HMM: 23-265/392.0
EQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIML
 ..| .||.  .| |  ..|  |..||||.  .|.| . . |     .  | |.||| |..  .   .  |||.|||  ....||||.|.||. | |.|.
feefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn...ekayiasqgpnaaslddfwrmvfqenvttiamv

TELVELGesmctrywptveipevlhgkilissleettldyytmrhfllsheeKGE-ERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKEtSSRPMI
|.| |                                               ||.  | |  ||| .||   ||. | ..| . ||..|.  .  ..|.|
tklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq.ythpli

VHCNDGIGRTGAFIAIDSLLRQkeVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQ-VLEKYEKnDRNGRPPMKIVESLRKVEDSESGKKVS
.||. |.||||  |.|||.. .   |   .. ..  .|  .|..|| ||||  || .||  |||          | ..... |.... |  |.  |
ihcsagvgrtgvvisidsvvah..akktrmv.dvfnfvtnirrkrpymvqtkeqyafiygavledllw.rntlipvvhftdhlqdlstssdGdvrs
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 122-383 8.6e-34 111.5 In-house 14-268 (281) alignment 
Range on Protein: 122-383
Range on HMM: 14-268/281.0
EQDFEELPSYLYSQD--KGNKIQNIHKNRYNASIPFDDNVISLKE--PSVYGSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSTIII
.|.| .||    |.     |.  | .||||     .|   . ||   |    . || |  |..     |.  || ||||   | .||||..|||..| |.
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf...lkrgyiltqgpkketradfwrmiwqenttaiv

MLTELVELGESMCTRYWPTVEIPEVLHGKILISsLEETTLDYY-TMRHFLLSHEekGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKtketsSRP
|| ...|     |. |.|      .   |. .|  |..|..      .. ||.|  || | . |. ...||   || |.  .|   ..| |.     | |
mlcqfletnrekcaeyfprnahcclqfdklsvs.yedstvnkslvttrlnlsye..getrlithwlwkewpdwqvpessevmlkilrkirar.....stp

MIVHCNDGIGRTGAFIAIDSLLRqkEVKGNNVLGEMKVLVESLRK-QRPGMVQTALQYRYIYQVLEKY
 ..||  |.||.|...|..  |.   ..    | ..| .|  ||   |   |||  ||  |..||  .
pvihcsagvgrsgtlmaveialq..sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_CG42327_pd Subfamily CG42327 122-305 3.7e-28 93.1 In-house 8-190 (319) alignment 
Range on Protein: 122-305
Range on HMM: 8-190/319.0
EQDFEELPSYLYSQDkGNKIQNIHKNRYNASIPFDD-NVISLKEPSVYGSTYINASPIKTASTGglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLT
 ..|..||  . . |    .    |.|.  ..|. . .|.. . ..   . |..|| ..       ...|||.| .|. . |||||.||. || .|. ||
aeefrdlPqliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda..pnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ELVELGESMCTRYWPTVEIP--EVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFrDWPVGSVPRSTGAFLDYWKEI
.| |||  .|..|.|| |    . |.|.||..  .  . | | .  .|| . .| | |.. |. . .|.   || .  |..    |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 123-414 2.2e-54 179.4 In-house 22-306 (515) alignment 
Range on Protein: 123-414
Range on HMM: 22-306/515.0
QDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLT
..| .||   .| |   ..  | .||||.  .|.| . . |        | |.||| |..  .   .  |||.|||......||||||.||. | |.|.|
eefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn...dkayiasqgPnkasvddfWrlvlqenvttiamvt

ELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKgeERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSsRPMIVH
.| |   . |..||| .    |  |.| .. .   .    . |.. . ....   | |  ||| .||   ||. | ..| . ||. |.. . .  |.|.|
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliih

CNDGIGRTGAFIAIDSLLRQKEvKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKNDRNGRPPMKIVESLRKVEDSESGKKVSP
|  |.|||| .|.||| . . . ... |  ..  .|. .|..|| .|||  || .||...  . .      | ... . |. .  |  |.  | 
csaGvGrtGvvisidsvvahak.ttrmv..dvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrsk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 124-384 2.3e-46 153.4 In-house 28-288 (325) alignment 
Range on Protein: 124-384
Range on HMM: 28-288/325.0
DFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYG-STYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLV--WQeqSTIIIML
.|. |||    ..    | .|. |||..  ...| . . |.     . | ||||| ...      .  ..|.| || .|| |.||||  |.  ......|
efgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk...kdvflaaqaPltatindlWrlvldWr..csvvvvl

TELvELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWP---VGSVPRSTGAFLDYWKEINAKTK--ETSS
 || .||.  |. |||      .  | . ..     ..  | .| . .   .||| | |  |... |.   |   | .  ..|.  |... . .    .|
nel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

RPMIVHCNDGIGRTGAFIAIDSLLRQkEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
 |..||| .|.||||.||.. |.| .  ..  .|  ..   |. |||.|| ||.|. ||  ||. | .. 
tpilvhcsaGvGrtGvfislysalak.vieesrv..difgfvkklrkdrpsmvetvdqyiliyealveay
0043336 (Phosphotyrosine protein) phosphatases II 125-383 5.7e-69 228.0 In-house 26-276 (278) alignment 
Range on Protein: 125-383
Range on HMM: 26-276/278.0
FEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTEL
||||.|. |.... .....|..||||   .|.| . . |.  .....|.||||| .   ..   . ..|||||||. |. ||||.||....|.|.|||||
feellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv...dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtel

VELGESMCTRYWPtveIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKeTSSRPMIVHCN
||||   | .|||      . .|.. .  |.|..||.||.|.. ...  .||.| | |.|. .|| ..|| |.  .||. |... . . .|. |..|||.
velgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCs

DGIGRTGAFIAIDSLLRQKEVKGnnvLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.|.||||.|||.. ||.| |  |      .   |. ||.||||.|||  |||..|..|  |
aGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 125-383 4.1e-52 172.2 In-house 32-283 (297) alignment 
Range on Protein: 125-383
Range on HMM: 32-283/297.0
FEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIKTASTgglqaQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTEL
|  ||.  ...| . .|  |..|.||. ..|.| . . |.       | |.||| .|.        ..|.|| | ..|. |||..|..|| ..|.||...
flclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.....rlittqmPmkatvadfWamvldeqvstivmlndd

VELGEsMCTRYWPTVEIPEvlHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPR--STGAFLDYWKEINAKTKETSSRPMIVH
 |  .  |.|||.   . .   |.. .  |  .    .  |.. .....   .| |  ..| .||. .|.|  |. ..|.. .|.. . ..... |..||
nerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CNDGIGRTGAFIAIDSLLRQ-KEVKGNNVLGemkvLVESLRKQRPGMVQTALQYRYIYQVLEKY
|  |.|||| ...||| . . |. |  ...|    ||. ||..|| .|||  ||...|... ..
claGvGrtgvlltidsvvaeakrekevdifg....lvkklrqerpylvqtkeqykfvyvavlea
subfamily_PTPRK_pd Subfamily PTPRK 126-380 1.6e-54 179.8 In-house 26-273 (314) alignment 
Range on Protein: 126-380
Range on HMM: 26-273/314.0
EELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVE
||  |..   |  .| .| .|||..  ...|   . |.       | ||||. | .       |..|.|||||. |. ||||||..|... |.|||||||
eeyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykr...paafivtqgPlqetvkdfWrlvydencasivmltelve

LGESMCTRYWPtvEIPEVlHGKILISSLEETTLDYYTMRHFLLSH--EEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKEtSSRPMIVHCN
 |   |..|||  |  || .|.| .  .| ..|  . .| | ...    . | | | .|.|  ||   || |  ..|.. ........| .  ...||| 
vgrvkClkyWP..edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCs

DGIGRTGAFIAIDSLLRQkeVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
 | ||||.|||||..|    .. ..|. ..   | .||.... ||.|  ||..||.|.
aGaGrtGtfiaidivldm..ieregvv.dvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 128-380 8.8e-55 181.2 In-house 46-287 (319) alignment 
Range on Protein: 128-380
Range on HMM: 46-287/319.0
LPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTelvelg
|.  |  |.  |  ||  |||.   ..|| ||. |.    . .| ||||| ..       . .|||.||||| |. ||||..|. ... |..||      
lgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr...kdkyiaaqGPldntladfWrmiweyncstivllt......

ESMCTRYWPTVEIPEVLHGKILISSLEETTLdyYTMRHFLLSH-EEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEI-NAKTKETSSRPMIVHCNDG
. .|..|||     .  ..|. ..|.|||    |..|.. ||.  .. . |..  |||. ||   || ..  ..   | .   ..||   ....|||  |
kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGAFIAIDSLLRQKEvkGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
.||||..|..| || . .   .. . ..  .|. ||.||. .||   || .||  |
vGrtGvyivldvlldrmk..eekqv.dvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN12_pd Subfamily PTPN12 132-384 1.2e-62 206.4 In-house 29-277 (290) alignment 
Range on Protein: 132-384
Range on HMM: 29-277/290.0
LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMC
 ||...|.| .|..||||   .|.| . . |..  .. || ||||. || ..    . .|||.|||| .|..||||..|. . .|..|. ..||||   |
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg...kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

TRYWPTVEIPEVLHGKILISSLEETTLD-YYTMRHFLLshEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKeTSSRPMIVHCNDGIGRTG
 ||||     |. .|.. ..  || ..|  ...| . .  | ..|.|.|  ||...||   ||.|.   |.  ....   . ... |..|||  |.||||
erYWpeegeeelefgefevtleeekavdddflirtLkv..eaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtG

AFIAIDSLLRQKEVkgNNVLG--EMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
. ||||   .. .   ...    ..  || .|||||. .|||  ||...|. .... 
tiiaidyvrellka..ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN1_pd Subfamily PTPN1 133-379 4.1e-54 178.3 In-house 22-266 (290) alignment 
Range on Protein: 133-379
Range on HMM: 22-266/290.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTR
... . .. .|  .|||    |.|   | |.. ..    ||||| ..      .. .|| |||||  |.. ||..||...|  ..|| ..|| ..  |..
fptreaklpenrnlnryrdvspydhsrikleradn...dyinaslvelee...akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPTVEI-PEVLHG--KILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEIN-AKTKETSSRPMIVHCNDGIGRT
|||. |   |.|    |. .  ..| . .|||.|.. |   .  | |...|||.  ||  .||.| .|||..  ..  . .  .   | ..||  ||||.
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GAFIAIDSLLRQKEVKGN-NVLGEMKVLVEsLRKQRPGMVQTALQYRYIYQV
|.|. .|..| . | |.. . .   |||.| |||.| |..||| | |. |. 
Gtfclvdtclvliekkddlssvdikkvlle.lrkyrlGliqtadqlrfsyla
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 133-385 6.9e-54 177.7 In-house 36-284 (290) alignment 
Range on Protein: 133-385
Range on HMM: 36-284/290.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY---GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESM
..   |.  .| ..||..  .. ||| | |.. |        ||||. ||  .    . ||||||||.  |. |||.|.|||..|||.|||. .| |.  
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke...kkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CTRYWPTVEIPEvlHGKILISSLEETTLDYYTMRHFLLSHEEK-GEERNVFHFHFRDWPV-GSVPRSTGAFLDYWKEINAKTKETsSRPMIVHCNDGIGR
|  |||. .  .   |.. |  |.|.||..|. |.. . .... |....| ....  |.  |.|.  ..  | . . .. . |..  ....||| |..||
CqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgr

TGAFIAIDSLLRQKEVKGnnVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKYEK
.. |.|..  . . . .|  |   ..| ..|.| |.||.|||. ||..|.|.. .| .
savfcaaattinkckteg..vidvfqv.lksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 134-383 5.2e-66 217.9 In-house 47-289 (298) alignment 
Range on Protein: 134-383
Range on HMM: 47-289/298.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTGGlqaQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTR
... ..| .| .||||   |..|   . |..  .   |.||||| .....       .||||.|| .|..||||.|..|... |.|||.|.||..  ...
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn...afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPTVEipEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFI
|||...  .  .|.| .| |.. .   ...|.. .|.... .||.| ..||  ||  .||. . . ||. ....|.....  .|.||.| .|.||.|.||
ywPdeg..ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi

AIDSLLRQkeVKGNNVLGEMKvLVESLRKQRPGMVQTALQYRYIYQVLEKY
||||.| .  || ..|.  ..  |. |||.|||.|||  || .||..  ..
aidsvler..vkkeqvvDvfq.vvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPN13_pd Subfamily PTPN13 134-380 1.2e-57 190.3 In-house 28-265 (273) alignment 
Range on Protein: 134-380
Range on HMM: 28-265/273.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVygstYINASPIKTAStGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRY
. ..|.| .| .||||   .|.|.  . |.. .     ||||| ||    |  . .|||.|||| .|..|||..||. ....|.|.|  .| |.  | ||
tcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPTVEIPE-VLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKetSSRPMIVHCNDGIGRTGAFI
||  .  . ...... .. |. . || ...|.. ... | || |.| |..| .||  .||.|.  .| . .|..   .  .. |..|||  ||||.|..|
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtli

AIDSLLRQKEVKGnnvLGEMKVLVESLRKQRPGMVQTALQYRYIYQVL
.|| .|   | .      ..| .|..||.|| |.|||  || ..|...
tidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 134-380 5.2e-54 178.7 In-house 16-251 (284) alignment 
Range on Protein: 134-380
Range on HMM: 16-251/284.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTelvelgESMCTR
 |   |  ||  |||.   ..|| ||. |.    . .| ||||| |.       . .||||||||| |. ||||..|. ... |..||      . .|..
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr...kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPTVEIPEVLHGKILISSLEETTLdyYTMRHFLLSH-EEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEI-NAKTKETSSRPMIVHCNDGIGRTGA
|||     .  ..|. ..|.||.    |..|.. ||.  .. . |..  |||. ||   || ..  ..   | .   ..||   ....|||  |.||||.
ywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FIAIDSLLRQKEvkGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
.|..| || . .   .. . ..  .|. ||.||. .||   || .||  |
yivldvlldrmk..eekqv.dvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 135-383 2.1e-26 87.6 In-house 35-270 (288) alignment 
Range on Protein: 135-383
Range on HMM: 35-270/288.0
QDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINAspiktasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRY
.   . |.|  ..||.     |   . |.. |  |  . . .       ..  . . | .| ||..||  .|... ...   |.||.||.|.|      |
diidsfianptrdryenlprcditrvklsddpdfyiaanvvs.......sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaey

WPTVEIPEVLHGKILISSLEETtLDY-YTMRHFLLSHEEKGEERN-VFHFHFRDWPVGSVPRStgaFLDYWKEINAKtkETSSRPMIVHCNDGIGRTGAF
.|..   ..  |..     ..   |   ...  ||  ...|||.  | . |...|.  .|| .   .| . . ..    ..  .|..||.. |.||||..
fPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPen...ylsplrllevl..kslqkPivvhssaGvGrtgtl

IAIdsLLRQKEVKGNNVLGeMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
| |  |.  . .. .. || .. |...||..|   .||  || |..... ..
ili..lialeslrlddflg.irsllaklreerfkaiqtemqylyvhrcvlee
0049772 (Phosphotyrosine protein) phosphatases II 136-388 5.5e-38 126.8 In-house 39-284 (314) alignment 
Range on Protein: 136-388
Range on HMM: 39-284/314.0
DKGNKIQNIHKNRYNASIPFDdNVISLKEPSVYGSTYINASPIKTAstgglqAQYIATQGPLDTTISDF----------WRLV--WQEQSTIIIM-----
 ....  |..||||   .|.| |   |.  .|.|| ||||| ...        ..|||||||. |. ||          ||.|  .. .. .| |     
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTELVELGesmctRYWPTVEIPEVLhgkilissleettlDYY-----TmrhfllsheekgeERNVFHFHFRDWPVGSVPrSTGA
                |..| ..|      ...  ....                . .                   ||......  ..| ||.| ..  
ladelsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf.............erlgikylripvpDgsap.lled

FLDYWKEINAKtkeTSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEmkvlvesLRKQRP-----GMVQTALQYRYIYQVLEKYEKNDR
|..  . |..       .| .|||..|.|||| |.... |...  |  . .| .       .|..||     |.... .|| .|...|..| |. .
fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealed.......vrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_ptpA1_pd Subfamily ptpA1 136-335 1.1e-26 88.6 In-house 40-250 (418) alignment 
Range on Protein: 136-335
Range on HMM: 40-250/418.0
DKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTAstggLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYW
 .|.| .|  ||||   .| .   . ||.     || ||||  |  |       |.|.|||||  ||.||||.||...  ||.||.   |     | |||
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga....ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PTVEIPEVL----HGKILI--SSLEET--TLDY---YTMRHFLLSHEekGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKE---TSS--RPMI
|     | .     |. ..   |.|      |       |   |. |  || |.. ....  ||   .|  |  | .  . |  . ..   .|    |.|
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe..getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCNDGIGRTGAFIAID
|||. |.||||.| .  
vhcsagvgrtgtfctav
0040439 (Phosphotyrosine protein) phosphatases II 137-384 4.9e-66 218.2 In-house 5-246 (249) alignment 
Range on Protein: 137-384
Range on HMM: 5-246/249.0
KGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWP
 ...  |..||||   .|.| . . |.  |....| ||||| |   ..   . ..|||||||. |..||||..|....|.|.|||.|||||   | .|||
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi...dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TveIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKET-SSRPMIVHCNDGIGRTGAFIAI
.    .. .|.. .  |.....|.||.|.. |.. ..||.| | |... |||  .|| |.  .||......   .|. .. |..|||..|.||||.|||.
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSLLRQKEVKGNnvlGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
. .|.| | ...     ..  |. ||.||||.||.  |||..|..| .. 
ylmleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN3_pd Subfamily PTPN3 137-383 6.9e-61 200.6 In-house 35-275 (280) alignment 
Range on Protein: 137-383
Range on HMM: 35-275/280.0
KGNKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTASTG-GLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWP
. .| .|..||||   .|.|.  ..||| ..    ||||. ..  . . ||  .||||||||..| .|||..||...|..|.|||.||| |   | .|||
aarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

TvEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAkTKETSSRPMIVHCNDGIGRTGAFIAID
. .  |. .|.. .   .| .   | .|...|...|. |||..... . .||  .|| ..  ||.. ..... .......|..|||  |||||| .|...
e.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlille

SLLRQKEVKGNnVlGeMKVLVESLRKQRPGMVQTALQYRYIYQV-LEKY
  |   | . . |   .  .|  .| ||  .|||| ||... .  |. |
talalieaaep.v.y.pldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 138-384 4.3e-64 211.1 In-house 4-242 (250) alignment 
Range on Protein: 138-384
Range on HMM: 4-242/250.0
GNKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESmCTRYWPT
..| || .||||   |..|   . |.. .    | ||||| ... .       .||||||| .|| ||||.|..|.|. |.|||.|.| ..  ...|||.
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder...kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

vEIPEVlHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDS
 | .|  .|....| |.. .   ||.|.. ||...| .|| | ..||  ||  .||. . | |.. |...|. ... ..|.||.|  |.||.|||||||.
.ekaek.yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

LLRQkeVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKYE
.| .  .| ..|.  .|| .. |||.||..|..  || ..|... |. 
vler..lkkekvvdvfkv.ikvlrkdrphavesleqyvfvyeiilkal
0042113 (Phosphotyrosine protein) phosphatases II 138-383 2.7e-63 209.0 In-house 4-242 (245) alignment 
Range on Protein: 138-383
Range on HMM: 4-242/245.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPT
.... |..||||   .|.|.. . |....   .|.|||||..   ..     ..|||||||. |. ||||..|....|.|.||||..|||   | .|||.
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv...dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

veIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDS
    .. .|.. .  |.|..||.||.|.. .... ..|.|.|.|.|. .|| ..|| ..  .||  ....   .|.|. |..|||..|.||||.|||.. 
..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

LLRQKEVKG--NnvlgeMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.|.| |  .  .     .   |. ||.||||.|||  |||..|..| ..
mleqlekelgvs.....leeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN14_pd Subfamily PTPN14 138-388 3.5e-57 188.7 In-house 44-300 (300) alignment 
Range on Protein: 138-388
Range on HMM: 44-300/300.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTV
..  .| .|||..  .|..|| . |.      . ||||| ||. | || . .||..||||..|. |||..||... ..|.||||  | |   . .|.|  
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikv.svggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkl

--EIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTK---ETS-----SRPMIVHCNDGIGR
  .  .| .||  ...   .. | .. . . | |   .|||.|.|. . |||   ||.    ||.| .|...  .   ...     . |..||| .|.||
eskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGr

TGAFIAIDSLLRQKEvkGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKNDR
||  |  | |.   |   |... ..|  .. ||.||  .|||  ||...|.|| || || |
tGvlilsdlliatle..hneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 138-386 2e-47 156.4 In-house 33-279 (287) alignment 
Range on Protein: 138-386
Range on HMM: 33-279/287.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTV
 ... ...||||   .|.||. . | . . .|| ||||  . .      . ..||.|||. .|. ||||.|....|. .|..|  || .   | .|||  
aeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytd...deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

EIPEVLHGKiLISSLEETTL--DyYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAF----LDYWKEINAKTKETSSRPMIVHCNDGIGRTGAF
| |  . |   .  |. . .  . |..| . | . |  | | |  ... .|| .... .. ..    ||  . |... . .   |..||.. ||||.| .
evPmrvGGy.svvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

IAIDSLLRQKEVKGNNvlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
.|.  |... |  |.    ..   |  ||..| ..||...|.|..|. |  | | 
latlvlvsrledlGrv...dvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_CG7180_pd Subfamily CG7180 138-383 7.5e-46 151.1 In-house 37-289 (296) alignment 
Range on Protein: 138-383
Range on HMM: 37-289/296.0
GNKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGEsMCTRYWPT
| . .|. |||.   .|.| | . |..      | ||||. . .      ...|| |..| . |. .|||||..|..  ...||.  .  . |.  ||| 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflk...kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

VEipEVLHGKILISSLEETTLDYYTMRHFLLSHE----------EKGEERNVFHFHFRDWPV-GSVPRSTGAFLDYWKEINAKTKET----SSRPMIVHC
    .  .|.|..  .|| ..   ..| | | ..          .| |.| | .|... |..  .|| || |...  . ..   ...       |..|..
ks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

NDGIGRTGAFIAIDSLLRQKEVKGN-NVLGEMKvlveSLRKQRPGMVQTALQYRYIYQVLEKY
.|| .|.|...|||  | . | ... .| . .|     ||..||..|..  .|.|||.||...
sdGasRsGvylaidanlelvekeeevdvFeavk....tlrrsRpqLvenveeYkyiYdvllea
0037934 (Phosphotyrosine protein) phosphatases II 139-382 1.3e-62 206.8 In-house 6-240 (243) alignment 
Range on Protein: 139-382
Range on HMM: 6-240/243.0
NKIQNIHKNRYNASIPFDDNVISLkepsvYGSTYINASPIKTAStgglqaQYIATQGPLDTTISD----FWRLVWQEQSTIIIMLTELVELGESMCTRYW
....|..||||   .|.|.. . |      || ||||. |.         ..|||||||. |. |    |||..|....|.|.|||||||||   | .||
llpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PtveiPEVLHGKILISSLEETTLDYYTMRHFLLSHEE-KGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKE-------TSSRPMIVHCNDGIG
|     || .|.. .  |.|..||.||.|..||.. . ....|.|.|.|.  || ..|| |.  .||...|...  .|        |..|..|||  |.|
p....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGAFIAIDSLLRQKevkgnNvlGEMKVLVESLRKQRPG-MVQTALQYRYIYQVLEK
|||..||.. .|..      .    .   |. ||.|||| .|||  |||..|..| .
RtGtliaaylmllll.....g..vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 139-380 3.1e-46 152.5 In-house 29-262 (283) alignment 
Range on Protein: 139-380
Range on HMM: 29-262/283.0
NKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTASTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVE
   .| .|||..  .| | ... ||  |    .||||. |  .     . .||..|.||| |. |||..|..|. | |.|||.| |  .  |..|||   
sadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

IPEvlHGKILISSLEETTLDYYTMRHFLLSHEEK-GEERNVFHFHFRDWpVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSL
  .  .|.  ..  .||| . .... .|| ..    ..  . |. . || .   . .    |  .  . .. .|    |..|||  |||||..|||. . 
sed..yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

LrqKEVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
.  |... . |. ..   |. .|.||...|||  ||. .... 
v..kdaltesvv.dvfavvkimreqrmmavqtldqyklvhelv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 140-383 6e-62 204.3 In-house 38-275 (281) alignment 
Range on Protein: 140-383
Range on HMM: 38-275/281.0
KIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPtVE
. .|..||||.  . .|   . . .. .   . ||||. ... .    ...|||||||. ... .||..||... ..|.|.|. .| |   | ||||  .
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg...ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.dd

IPEVLHGKILISSLEETTLDYYTMRHFLLsHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLL
  |.  |.. ..|..|..   |  |.| | ..|.||.|.| ....  ||   || .| ..|.. ||..  |.. .  |...||  |.||||..||.| |.
nselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

RQKEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.. | . ...  ..| .|..|||.|  |||| .||...|... ..
kaveaeleel..dvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 140-385 3.8e-56 185.0 In-house 17-265 (270) alignment 
Range on Protein: 140-385
Range on HMM: 17-265/270.0
KIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKtaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVE
 ... . |||.  .|     . |.| .    ..||||  ..     | ...|||..|||.||...|||..|.|..| |.|.|.|.| | . | ||||.  
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvr..GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

IP--EVLHGKILISSLEETTLDYYTMRHFLLSheEKGEERNVFHFHFRDWPVGSVPRSTG------AFLDYWKEINAKTKETSS-RPMIVHCNDGIGRTG
    .. .||| . .|.|.  . | ...  |   ||||||.. ||.. .||  .|||...        |   ... . .||..   |..||| .|.||||
kekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

AFIAIDSLLRQKEVKGNNvlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
 .||.|  .|  | ...    ..  ..| |||.|. .||.  ||...|... .| .
tlialDiavrlLeetkkv...dvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 140-378 2.9e-45 149.3 In-house 4-234 (239) alignment 
Range on Protein: 140-378
Range on HMM: 4-234/239.0
KIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVE
|  |  ||||   . .| . . |.. |    | ||||| ..     |    |||||| . ..  ||||..|||.  .|.||| |.|  .  | .|||   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

IpEVLHGKILISSleETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINaKTKETSSRPMIVHCNDGIGRTGAFIAIDSLL
  .    .. .       .  | .| |..|.  . ||| |...||  ||   ||. . | |   ..|  |     .|| ..||. |.||||||. ||..|
s.kycnlrvtlrk..tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidaml

RQKEVKgNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQ
|| . . . |  ..   |...|..|| ||||. || .|. 
rqakkq.ktv..difnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 140-378 3e-45 149.2 In-house 5-235 (239) alignment 
Range on Protein: 140-378
Range on HMM: 5-235/239.0
KIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVE
|  |  ||||   . .| . . |.. |    | ||||| ..     |    |||||| . ..  ||||..|||.  .|.||| |.|  .  | .|||   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

IpEVLHGKILISSleETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINaKTKETSSRPMIVHCNDGIGRTGAFIAIDSLL
  .    .. .       .  | .| |..|.  . ||| |...||  ||   ||. . | |   ..|  |     .|| ..||. |.||||||. ||..|
s.kycnlrvtlrk..tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidaml

RQKEVKgNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQ
|| . . . |  ..   |...|..|| ||||. || .|. 
rqakkq.ktv..difnyvkairedrphmvqtseqyvfihl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 140-386 1.9e-39 130.1 In-house 53-285 (290) alignment 
Range on Protein: 140-386
Range on HMM: 53-285/290.0
KIQNIHKNRYNASIPFDDNVISLKEpsVYGSTYINASPIKtastgGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEI
|  ...||||   .  |   . ||.   |   |. |  .|     ||.| .| |||.|  |. |.||.| ||. . |.|| ||.| | . | .|.|  | 
kntefkknrykdvvcndktrvilkd..GydGdyvhanyvk.....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

PEVLHGKILISSLEETTLDYYTMRHFLL-SHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEInaktkETSSRPMIVHCNDGIGRTGAFIAIDSLL
  .  |.| .   ||.. |  .... |   . ..| |  . |.. . ||  ||. || |.|   . .      . | |..|||  ||||||.|.||.  |
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrtGtfvaievgl

rQKEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEKN
 |  ..| ..  ..  || .||. | . ||  .||  . ..| .. |.
.qilldGkel..dlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 140-383 4.7e-35 115.7 In-house 53-288 (305) alignment 
Range on Protein: 140-383
Range on HMM: 53-288/305.0
KIqNIHKNRYNASIPFDDNVISLKEPSvyGSTYINASPIKTASTGglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEI
.| .| ||||.     | ... |..||   | || |  .        . ..|..||||| || .|| .| |..   |.||   ||||   |..|||.   
di.aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmip..ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

P-EVLHGKILISSLEET-TLDYYT-MRHFLLSHEE-KGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINaktkeTSSRPMIVHCNDGIGRTGAFIAID
    |.. |..  .  .  ..  . ..  ||      ...  | |... .||   ||    . |.    |       |  |..|||  ||||||. .||.
eklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.....gskvpivvhcsagigrtgtivaie

SLLRQkeVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
 .| .  .  |.    |  || .|| ||   .|. .|| .|..|. .|
yilek..iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 140-385 7.1e-34 111.9 In-house 45-288 (305) alignment 
Range on Protein: 140-385
Range on HMM: 45-288/305.0
KIQNIHKNRYNASIPFDDNVISLKEPsvYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEI
. |. .||||     .|.| . |. |  .   || |  . | .      ..| || ||. | .||| . .|..   |.|| .|.| |   |. |... . 
eaqeagknrykdvgcldnnrvklegp..wpheyihanyvstptn...pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

PEVLH----GKILISSLEETTLDYYT-----MRHFLLSHEEKGE-ERNVFHFHFRDWPVGSVPRSTGAFLDYWKeinaKTKeTSSRPMIVHCNDGIGRTG
...       || .     .||.. .     ...  |  |  ||  | | |.|. |||   || .  | |.  .    |.. .|  |..|||  ||||||
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle....kar.pskgpivvhcsagigrtg

AFIAIDSLLRQKeVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQVLEKYEK
. . .. .| |  . |. .    |. .  .|.||   .||  || ...||. .| .
svvmleyildql.lagqiiedtdki.lqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_PTPN9_pd Subfamily PTPN9 141-384 3.6e-50 165.7 In-house 40-290 (297) alignment 
Range on Protein: 141-384
Range on HMM: 40-290/297.0
IQNIHKNRYNASIPFDDNVISLK-EPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEI
  |..||||.  . .|.  . |. ..    | ||||. .        .  .|||||||. |.|||||.||...  .|.| | .|| |   |..|||. | 
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq...kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

PEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAK------------TKETSSRPMIVHCNDGIGR
    .|.. .|..|  . . |..| . ... ...|.|.| || |  ||   ||.|. ..||  ...  |            . ..|  |..|||  ||||
ssaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

TGAFIAIDSLLRQKEVKGNNvlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
||.||..|  | . | .|.    ..   |. ||.||  ..||  || . |. .  | 
tGtfitldiclsrleevgtv...dvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 141-385 8.7e-27 88.5 In-house 50-291 (310) alignment 
Range on Protein: 141-385
Range on HMM: 50-291/310.0
IQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIP
 ...|||||   .  |.  . ||        || |  .||     |.. .| .||||. || ||||...||..  |..|   .| |   |  |||.. . 
kkymhknrysdvvcldtsrvklkidksryedyihanyvktny...lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

EVlHGKILISSLEETTLDYYTMR---HFL---LSHEEK---GEERNVFHFHFRDWPVGSVPRSTGAFLDywKEINAKTKEtssRPMIVHCNDGIGRTGAF
|  .| | .. | |.. ..        |.   .  .|.    .|  |   .. .||   ||      .   . . |. .     | .|||  |..|... 
et.ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqvrh...gpcvvhcsagkdrlyvv

IAIDsLLRQKEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
.|.. |  .|  .|..|  ... ..  |.|.|   .|| ||| .| .|   . .
valk.lkidkldrglkv..daeevktellksraiciqtelqyliidrvriifar
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 141-242 3.6e-13 43.7 In-house 94-186 (244) alignment 
Range on Protein: 141-242
Range on HMM: 94-186/244.0
IQNIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGEsmctrYWPTVEIP
 .| .|||  |..||| | . | . |. | |||||| .      |  |.|| || ||  |  |||... .    ....|  . |  |     |||  |  
pnnswknregaglpfdfnrvplskgsm.gntyinasfvgcl...grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdsepl

EV
| 
ew
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 142-383 1.5e-48 160.2 In-house 46-277 (287) alignment 
Range on Protein: 142-383
Range on HMM: 46-277/287.0
QNIHKNRYNASIPFDDNVISLKepsVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIpe
|| .|||..  .. |.. . ||        ||||. |.. .    . ..|....|.  |. .||.|..... |.|.||... |  |..| .|||. .   
qnkdknRltqilvpdnyrvllk...gehpdyinavfidgyke...kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..

VLHGKILISSLEETTLDYYTMRHFLLSHEE-KGEERNVFHFHFRDWPV-GSVPRSTGAFLDYWKEINAKTKETSsRPMIVHCNDGIGRTGAFIAIDSLLR
|. |.  |. |.|.. . |..|.. . ... .|....|  ... .|.  | |..    .|   . . .. |..   ...||| |..||.. |.|..  ..
vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn.tsivvhCsdtvGrsamfcaaattin

QKEVKGnnVLGEMKVLvESLRKQRPGMVQTALQYRYIYQVLEKY
. .  |  |.  ..|| .| | |.||.|||. ||..|.... .|
kckteG..viDvfqvl.ksqriqkpgsvqtveqykfindivley
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 142-383 6.1e-37 122.3 In-house 40-276 (307) alignment 
Range on Protein: 142-383
Range on HMM: 40-276/307.0
QNIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPE
 | .||||.     | . | .| . .  | || |  . .|       ..|..||||..|. .|| .. ||.   .||| ...||..  | .||| .|  .
antdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaik...pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

VLHGK----ILISSLEETTL--DYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYwkeINAKTKETssRPMIVHCNDGIGRTGAFIAId
  .|.    | .. |   .|  |   .    |  .  .. | . |. . .||   ||.   . ..    ..|   .|   |..|||  |.||.|. .|| 
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavrydt..npvvvhcsaGvGrsGtivai.

SLLRQKEVKGNNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
||...| ..| |   .|| ||| ||.||.  .|| .|| |...|| .|
slvqdkmiaGinck.dmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 142-293 8.1e-26 85.6 In-house 32-181 (297) alignment 
Range on Protein: 142-293
Range on HMM: 32-181/297.0
QNIHKNRYNASIPFDDNVISLKEpSVYGSTYINASPIKTAsTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPE
  ..||||.  . .||. . |.  .. .. ||||  .        . .|| .||||..|. |||.||....  .|.|...| | | . |. ||| |.   
sslrknryrdilatddtrvkllr.viterdyinadyvvfp.deeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPR
   |....  | .|. .. ..    |    . |.| | |  |  ||   || 
lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
Y_phosphatase Protein-tyrosine phosphatase 143-380 3.5e-66 218.3 Pfam-A 1-233 (235) alignment 
Range on Protein: 143-380
Range on HMM: 1-233/235.0
NIHKNRYNASIPFDDNVISLkEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEV
| .||||.  .|.|.. . | . |   | ||||. .|. ..   . ..|||||||. ||.||||.||||....|.|||.|.| |.  | .|||. |  ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

LHGKILISSL-EET-TLDYYTMRHFLLSHEEKG-EERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTkETSSRPMIVHCNDGIGRTGAFIAIDSLLR
 .|.| .    .|.   . ||.|.. |.....  |.| | ..|. .||  .||.|. ..||. .... .. |..| |..||| .|.|||| |.|.| ||.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

QKEVKGNnvlGEMKVLVESLRKQRPGMVQTALQYRYIYQVL
| | ...    ... .|..||||||||||.. || ..|...
qleaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 143-380 3.5e-66 218.3 In-house 1-233 (235) alignment 
Range on Protein: 143-380
Range on HMM: 1-233/235.0
NIHKNRYNASIPFDDNVISLkEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEV
| .||||.  .|.|.. . | . |   | ||||. .|. ..   . ..|||||||. ||.||||.||||....|.|||.|.| |.  | .|||. |  ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

LHGKILISSL-EET-TLDYYTMRHFLLSHEEKG-EERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTkETSSRPMIVHCNDGIGRTGAFIAIDSLLR
 .|.| .    .|.   . ||.|.. |.....  |.| | ..|. .||  .||.|. ..||. .... .. |..| |..||| .|.|||| |.|.| ||.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

QKEVKGNnvlGEMKVLVESLRKQRPGMVQTALQYRYIYQVL
| | ...    ... .|..||||||||||.. || ..|...
qleaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 143-380 4.3e-52 171.7 In-house 3-235 (237) alignment 
Range on Protein: 143-380
Range on HMM: 3-235/237.0
NIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEV
|  ||||   . .| . . || .   || ||||. .|     |   .|||.||||...  |||..||||. ..|.||| |.|  |  | .|||  . |. 
nkiknrygnivaydhsrvvlkgags.gsdyinatylkgf..dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

lHGKILISSLEETTLDYYTMRHFLLSHEEKG-EERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKE-TSSRPMIVHCNDGIGRTGAFIAIDSLLRQ
 .|.. .|   .  .  ||.| .|||.. .  | | .. ..|  ||   ||. | |.| . |.|  ...  . | | |.||. |.|||| |. ||..|||
.ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

KEVKgnNVLgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
 . |  .|. ..   | |. ..|| ..||  || .|.|..
akek..kvv.diynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 143-385 1.5e-38 127.5 In-house 1-172 (182) alignment 
Range on Protein: 143-385
Range on HMM: 1-172/182.0
NIHKNRYNASIPFDDNVislkepsvyGSTYINASPIKTASTGGLqaqYIATQGPLDTTISDFWRLVWQEQSTIIIMLTelvelgesmCTRYWPtveipev
|..||||   .|.| .          ...||||. .  .  .     .|||||||. |. ||.|...... |.|..||         . .|||       
nldknrysdilpydhsr.........dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

lhgkilissleettldyytmrhfllsheeKGEERNVFHFHFRDWPVGSVPRsTGAFLDYWKEINAktketSSRPMIVHCNDGIGRTGAFIAIDSLLRQke
                             . .||.......  || ..||  .  .||. .|...     ...| .|||. |.||||...|.. ....  
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl..

vkgnnvlgE--MKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
        .  .   |. .|..|||||.|  ||......|  . .
........gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 144-380 1.9e-43 143.6 In-house 49-275 (439) alignment 
Range on Protein: 144-380
Range on HMM: 49-275/439.0
IHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTGGLqaqYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGEsmctrYWPTVEipEV
  ||||.   .||   . | . | |  | ||||  ||   .  |   ||||||| . |  ||||||...... |.|||.|||        |||. .  ||
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl...yiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda..ev

LHGKILISSLEETTLDYYTMRHFLLSHE--EKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRQ
 .| | .    .  |  |..| | .  |      || |..||.  ||   ||  .   ||. . ||.   .    |..|||  |.||||. ||.|  | |
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

KEVKgNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVL
  .. |.|  ..| .|. |||||  |||.  || .||. .
lkle.nkv..dikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 145-383 3.8e-26 86.7 In-house 37-269 (285) alignment 
Range on Protein: 145-383
Range on HMM: 37-269/285.0
HKNRYNASIPFDDNVISLKEpsvYGSTYINASPIKTasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLH
  |||      ..  . ||.   .   || || ..    |  |. ||.|||||  |.||||....||. . ..||  |.| |   |. |.|      |  
dlnryadvrcieetrvvlkn...hdrdyihaswmrm..pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GKILI--SSLEETTLDYYTMRHFLLSHEEK--GEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEInaKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRq
||  |  .  .| ..    .  . .   |    |   . | .   ||    |  .  ... .| .  |  .   .|. |||. |.||| .|. ||     
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwv..kkvnpkekpicvhcsagvgrtatfvgidyati.

KEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
. ..  |.  ||  .|  .|  |   ||. .|. ..| || .|
rimenpni..emldivremramrfqavqshmqflflyvvlmey
0044763 (Phosphotyrosine protein) phosphatases II 163-386 1.5e-24 82.0 In-house 11-173 (178) alignment 
Range on Protein: 163-386
Range on HMM: 11-173/178.0
KEPSVYGSTYINASPIKtastGGlqaQYIATQGPldttiSDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIpevlhgkilissleettldyytm
. . . .| ||||| |     .|    |.....|     .|...|....  | |..||| .|||   | .|||. .                        
nleglersdyinaseil....pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................

rhfllsheekgeernvFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKeTSSRPMIVHCNDGIGRTGAFIAIDSLLRQkevkgnNVlgEMKVLVESLRKQ
                .....  .| ..|| ..  ||.  . |..  . .. .| .|||. |.||.|...|.. ....      ..   .   .| .|..
................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl......gl..sleeaielvrer

RPgMVQTALQYRYIYQVLEKYEKN
|| .|..  |.|..|.. ... |.
Rp.ivpnpgqlrqLyefelrllke
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 166-420 9.8e-23 75.7 In-house 42-283 (290) alignment 
Range on Protein: 166-420
Range on HMM: 42-283/290.0
SVYGSTYINASPIKTAStgGLqaQYIATQGPLD-------TTISDFWRLVWQEQSTIIIMLTELVELGES----MCTRYWPTVEIPEVLHGKILISSLEE
. . . || |. .. ..  ||  . |.|| |.         || .|| .. ||... ..|| |  |  .      |..| |. .  |.  . . ..  . 
krfnddyiHAnrvtcpn..gl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCksk

TTLDYYTMRHFLLSHEeKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINakTKETssrPMIVHCNDGIGRTGAFIAIDsLLRQKeVKGNNVLGEMKV
 . |   .|. .. .. ..||  | |  ...|   .|...|  .|.  . ..  ...|   |.|||| ||| |  |. ||. |  || . . .   ....
ekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk..askt...pvivHcvdGiSrsAalaaii.lgyQk.iaetsgsvkled

LVESLRKQRPGMVQTALQYRYIYQVLEkyekndrngrppMKIVESLRKVEDSESGKKVSPLLRNIY
....|||||  ....||.. ..  ..             . ..| |.... .|. ||.    .. |
vlkalrkqralaitsalelafvdagiv............llaievldqfaeeetekkakaeekety
0046846 (Phosphotyrosine protein) phosphatases II 167-384 2.3e-34 114.0 In-house 9-173 (176) alignment 
Range on Protein: 167-384
Range on HMM: 9-173/176.0
VYGSTYINASPIKTAstgglqaQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVlhgkilissleettldyytmrhfl
 ....||||. | ..        .|||||||  |. ||........ |....|||.||||   |..||| .| ...                        
dldldyinanlilgs.......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lsheekgeernvfHFHFRDWPVGSVPRStGAFLDYWKEINAKTKETssRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVlgemkvlVESLRKQRP-G
             .... .|| ..|| .  ..|.  ..|.   ||   .| .|||  ||||||...|.. | ..| .. ...       .. .|.||| |
.............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveea.......lalvreqRplg

MVQTALQYRYIYQVLEKYE
.|||  |||..|... .. 
avqtpeQyrflyefellll
subfamily_egg_pd Subfamily egg 167-381 2.6e-24 80.5 In-house 65-267 (307) alignment 
Range on Protein: 167-381
Range on HMM: 65-267/307.0
VYGSTYINASPIKtasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELgeSMCTRYWPTVEIPEVLH--GKILISSLE--ETTLDYYTM
 |   .| |  .|    . |  ..| .| ||  |  ||||.|.||.   |.|||  .|     |  |||  |   .    | . | .|.  ...   ...
qylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrv

RHFLLSHEEkGEERNVFHFHFrDWpvgsvPRSTGAFLDYwkEINAKTKEtSSRPMIVHCNDGIGRTGAFIAIDSLLRqKEVKGNNVLGEMKVLVESLRKQ
 .. |   .  ||| . |.   |.       |.  .  .  ..  | ..  |.|..|.. .|. ......||.  |  . ..|  .   ..  |  ||..
tklklvGgd.deerflehwqg.dv.....nnssdvyspl..rvlrklrn.lskpvvvqdilGvskaatlvaieiall.sllrGpitkslvlravvflrlr

RPGMVQTALQYRYIYQVLE
|.  |...|.| ..|... 
rrlsvesvllylfvyrlvl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 167-288 3.1e-07 24.8 In-house 10-123 (130) alignment 
Range on Protein: 167-288
Range on HMM: 10-123/130.0
VYGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGEsmctrYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFL
. | |||||| .      |  |.|. || ||  |  |||... .    ....|  . |  |     |||  |  |    .|.... .    ..    .. 
lqgntyinasfvGll...grtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnle

LSHEEKGEERNVFHFHFRDWPV
 ... .   . .  |.  .|| 
iesdlneshqaltmfqisnwps
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 168-238 5.7e-10 33.0 In-house 88-157 (349) alignment 
Range on Protein: 168-238
Range on HMM: 88-157/349.0
YGSTYINASPIKTASTGgLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVE
    ||||  .| .     . .||||| || .|. ||....  ..  ... |..  ||.   | .||   .
klddyinanylkltris.vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
0051429 (Phosphotyrosine protein) phosphatases II 169-384 3e-44 147.0 In-house 3-225 (272) alignment 
Range on Protein: 169-384
Range on HMM: 3-225/272.0
GSTYINASPIKTAstgG---LQAQYIATQGPLDTTISDFWRLvWQEQSTIIIMLTELVELGESMCTRYWP----------TVEIPEVLHGKILISSLEET
 |.||||. ...    |   .   .....|||. |. ||||| .... . |..|....|.|   | ||||            . |..|.|.. .  |.|.
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

TLDYYTMRHFLLSHE-EKGEERNVFHFHFRDWPVGSVPRSTgaFLDYWKEINAktketsSRPMIVHCNDGIGRTGAFIAIDSLLrqKEVKGNNVLGE---
.|..|..|..||...   || | |.|.|..|||  .||...  .|.  .....      ..|..|||. |..||| ..|.. ||    |  . .. .   
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYll

----MKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
    .   || ||.||||.|||  ||...|..| .. 
tnlyleeaveelraqrpgavqteeqylflyeallell
0036282 (Phosphotyrosine protein) phosphatases II 169-378 2.9e-37 123.4 In-house 1-164 (174) alignment 
Range on Protein: 169-378
Range on HMM: 1-164/174.0
GSTYINASPIKTASTGGlqaQYIATQGPLDttisdFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTveipevlhgkilissleettldyytmrhflls
||.||||||..     .    .||.||||.     ||........|...||.|..|||  .| .|||.                                
gsdyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

hEEKGEERNVFHFHFRDWPVGSVPRSTGaFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVlgemKVLVESLRKQRPGMVQ
   . .||.......  || ..|| ..  .|.  |...   .| ...|..|||. |.||||...|.. .||... .  ..      || .||.|||||||
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvda....ldlvrelRlqrpgmvq

TALQYRYIYQ
|  |||..|.
tpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 169-378 8.2e-36 118.7 In-house 4-155 (172) alignment 
Range on Protein: 169-378
Range on HMM: 4-155/172.0
GSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELvelgesmctrywptveipevlhgkilissleettldyytmrhfllS
||.|||||....        ..|||||||. |..||||...... |.|..||||                                              
gsdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

HEEKGEERNVFHFHFRDWPVGSVPrSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLrqKEVkgnnvlgEMKVLVESLRKQRPGMVQ
.  ...||.......  || ..|| ..  .|.  . |. .  . .. |..|||  |.||||...|.. .|  . .        .   |. .|..|||.||
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml..lgl.......sleeavalvrekRpgavq

TALQYRYIYQ
.  |||..|.
npsqyrflyy
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 169-221 5.7e-08 26.7 In-house 69-118 (347) alignment 
Range on Protein: 169-221
Range on HMM: 69-118/347.0
GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTE
  |||||| ||   .   . .|| || ||  |. |||..|   . | .. . |
vetyinashikfdna...skeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
0051082 (Phosphotyrosine protein) phosphatases II 170-381 7.8e-31 102.1 In-house 3-150 (151) alignment 
Range on Protein: 170-381
Range on HMM: 3-150/151.0
STYINASPIKTAstgglqaqYIATQGPLDttisDFWRLVWQEQSTIIIMLTELVELGesMCTRYWPTVEipevlhgkilissleettldyytmrhfllsh
|.|||.| .           .....|||.    ||..|..... . |..|....| |  .|..|.|  .                               
sdyinfsyvtgg........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................

eekgeeRNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAktkeTSSRPMIVHCNDGIGRTGAFIAIDSLLrQKevkgnnvlGEMKVLVESLRKQRPGMVQT
      ..|.|... |||. ..| |. |.|........    ... |..|||. |.||||...|.. .| ..          .   .| .|..|||.||.
......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylml.lg........vsleealeeyrlkrpgvvqp

ALQYRYIYQVLE
  |.......|.
nqqflfqlfall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 172-382 1.3e-18 61.8 In-house 69-274 (312) alignment 
Range on Protein: 172-382
Range on HMM: 69-274/312.0
YINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPT-VEIPEVLHGKILISSLEE-----TTLDYYTMRHF
|| |  .|  .      ....|||||. |.. ||.|.    || ||.|. .|| |   |..|    | . ..   ..   .  |      . |  | | .
yihanfvkictk...perfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvl

LLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYwkeINAKTKEtsSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLvesLRKQRPG
 .     |.| .. |. .  ||   .| |  . |     . |  |.   .|.| ||  |.||||... |.|..       .. . .. ||   |||.|  
kvvvkatgqesklnhyqwaswpdhgmpdscdtalrl...lsavkkd..kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrar

MVQTALQYRYIYQVLEK
 |..  || |  ... .
svrvfpqyvyalrcvle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 182-375 1.8e-28 94.1 In-house 84-272 (301) alignment 
Range on Protein: 182-375
Range on HMM: 84-272/301.0
STGGLQAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHGKIL--ISSLEETTLDYYTMRHFLLSH-EEKGEERNV
.| |   ..|||||||. |  ||| .. | .   |.||.. ||  |..|. | |.    ..  |.    | . |    .  . |.. .    .| . | |
ptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtv

FHFHFRDWPVGSVPRSTGAFLDYWKeINaktKeTSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEvkGNNVLgEMKVLVESLRKQRPGMVQTALQYRY
 |. . .|.   ||.|     |  . .    |  | .|..|||..||||. |||. . | |. |   .. . |..  .. ||..|   |||  |  .
thyqysewtdrgvPkshaelfdlme.lv...k.ksekPivvhcsaGiGrsvafigteylareve..adpti.eltealkhlrehrwngvqtnsqlyw
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 187-379 1e-26 88.4 In-house 4-199 (199) alignment 
Range on Protein: 187-379
Range on HMM: 4-199/199.0
QAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEK--GEERNVFHFHFR
| .||||| ||  |..|||..||.  |  |.|. .     |.    ||||.|     .| . ...   ||   ||.  ..|. .       |.. |. | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPVGSVPRST--GAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQV
 |   . |  .    |.   .|.  | ..    |.|||| || | || |.|.|  .| .|     |.  ..|    ||. | |.. .  .| .||||
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfev.akrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 187-379 1e-26 88.4 In-house 3-198 (198) alignment 
Range on Protein: 187-379
Range on HMM: 3-198/198.0
QAQYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEK--GEERNVFHFHFR
| .||||| ||  |..|||..||.  |  |.|. .     |.    ||||.|     .| . ...   ||   ||.  ..|. .       |.. |. | 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPVGSVPRST--GAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVlVESLRKQRPGMVQTALQYRYIYQV
 |   . |  .    |.   .|.  | ..    |.|||| || | || |.|.|  .| .|     |.  ..|    ||. | |.. .  .| .||||
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfev.akrlrqarcgiisslqhynfiyqv
0049260 (Phosphotyrosine protein) phosphatases II 189-379 1.6e-32 107.6 In-house 10-145 (152) alignment 
Range on Protein: 189-379
Range on HMM: 10-145/152.0
QYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWptveipevlhgkilissleettldyytmrhfllsheekgeernvfHFHFRDWPV
..||||||.. |..||||.... . |.|.|||||.|||.  | .|.                                             ....  || 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpD

GSVPRSTGAFLDYWKEINAKtKETSSRPMIVHCNDGIGRTGAFIAIDSLLrqkevKGNNVLGemkvLVESLRKQRPGMVQTALQYRYIYQV
..|| ..  .|.  . |.   .. .. | .|||  |.||||...|.. .|     .| ...      |. .|..|||.|..  |.|..|..
hgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.....lgvslee....avalvrekRpgavpnpgqlrflyef
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 189-236 3.1e-10 34.0 In-house 237-281 (440) alignment 
Range on Protein: 189-236
Range on HMM: 237-281/440.0
QYIATQGPLDTTISDFWRLVWQEQSTIIIMLTELvelGESMCTRYWPT
 .|||| |||.|. |||||| . . . |||| .|    .  |. ||| 
afiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 196-380 4.5e-13 43.3 In-house 99-284 (302) alignment 
Range on Protein: 196-380
Range on HMM: 99-284/302.0
PLDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLE-ETTLDYYTMR-HFLL-------SHEEKGEERNVFHFHFRDW
|   |.  .| |. | . .|.. |...|| .|  |. |. .    |.  |.  . ... .| |. .| . .| |       .. .|  .. |  ..|  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PVGSVPRSTGAFLDYWKeinakTKETSSRPMIVHCNDGIGRTGAFIAIDSLLrqkEVKGNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVL
|    |. . . ||  |       |.  . ..|||  |.||||...||   .   ..  ..   ..  .|  .|. | | ||.. |  |.  ..
pdhGapkeaytaldilk.....fcesykknvlvhcsaGvGrtGtlvaikyGi...qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 197-380 1.3e-19 65.3 In-house 36-218 (255) alignment 
Range on Protein: 197-380
Range on HMM: 36-218/255.0
LDT-TISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRST
|.. |.  |.. . | ... ..||... | |   | .|.|.         .. ... . ..      .. ..   || . ..| |.... |.    |. .
lysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

GAFLDYWKEInaktkeTSSRPMIVHCNDGIGRTGAFIAIDSLLR--QKEVK-GNNVLGEMKVLVESLRKQRPGMVQTALQYRY-IYQVL
   |  .| .      . |....|||. ||||. ||. .... .   . ..  . |  . . |.| ||..|.. ..| ||  . |. ||
reilnilkvv......rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_hpo-7_pd Subfamily hpo-7 197-383 1.8e-16 54.8 In-house 43-227 (263) alignment 
Range on Protein: 197-383
Range on HMM: 43-227/263.0
LDTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHGKILISSLEETTlDY-YTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRST
|  ||  |.. . | ... ..||..  | |   | .|.|.         .. ... .    |     ...|   .|| . ..| |. .. |.    |. .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpela

GAFLDYWKeINaktkeTSSRPMIVHCNDGIGRTGAFIAIDSLLR--QKEVK-GNNVLGEMKVLVESLRKQRPGMVQTALQYRY-IYQVLEKY
   |   | ..     . |....|||. ||||. ||  .... .   . ..  . |  .   |.| ||..|.. ..| .|  . |. ||.  
reilnilk.va.....rnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
0048076 (Phosphotyrosine protein) phosphatases II 232-382 7e-22 73.1 In-house 1-141 (145) alignment 
Range on Protein: 232-382
Range on HMM: 1-141/145.0
RYWPTVEIPEVLHGKILISSLEETTLDYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETssRPMIVHCNDGIGRTGAF
.|||.  .| .  | .   .  |.  |.   . . |..|....||....... .||  .|| ..  .|.  . |..  ||   .|..|||. |.||||..
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtl

IAIDSLLRQKeVKGNNVLGEmkvlvesLRKQRPGMVQTALQYRYIYQVLEK
.|.. .|... |   ..| .       .|.||||.|..  |.|..|.....
vaaylmlllg.vsleealel.......vrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 258-378 1.2e-18 62.7 In-house 29-139 (144) alignment 
Range on Protein: 258-378
Range on HMM: 29-139/144.0
DYYTMRHFLLSHEEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKetSSRPMIVHCNDGIGRTGAFIAIDSLLRQKeVKGNNVLGEMkvlve
. .|   .  ..|   .||....... .||  .|| ..  .|.  . |..  .  ...|..|||. |.||||...|.. ..... .  ...| ..     
gittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklg.lsleealalv.....

slRKQRPGMVQTALQYRYIYQ
  |..|||.|..  |.|....
..rsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 273-380 2.8e-18 60.5 In-house 86-191 (440) alignment 
Range on Protein: 273-380
Range on HMM: 86-191/440.0
GEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAIDSLLRqkEVKGNNVLgEMKVLVESLRKQRPGMVQTALQ
 | | . ..|.. ||  .||. .|  |   ...|   ..... |..|||. | ||||  ||.||.||  |.| .. . ..  ...|.|..|| ||||  |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilr..eakrsdqi.difsfinsmrnnrpqmvqtpeq

YRYIYQV-L
| ..... |
yafvheavl
PTPc_DSPc_SM00012 279-380 1e-26 88.5 In-house 3-103 (105) alignment 
Range on Protein: 279-380
Range on HMM: 3-103/105.0
FHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETS-SRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIY
 |.|. .||  .||... ..|.. .... .... . | |..||| .|.|||| |.|.| ||.| | . ..|  ... .|..|||||||||||  || ..|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkev..difqivkelrkqRpgmvqteeqylfly

QVL
..|
ral
0038934 (Phosphotyrosine protein) phosphatases II 281-334 2.7e-06 22.7 In-house 80-135 (194) alignment 
Range on Protein: 281-334
Range on HMM: 80-135/194.0
FHFRDWPV---GSVPrSTGAFLDYWKEINAKTKETSSRPMIVHCNDGIGRTGAFIAI
... ..|.   |.|| |.   |.. . .. ...| ..    |||  |.|||| ..| 
ieylklpfpddgtvP.sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 282-387 2.3e-12 41.0 In-house 187-288 (302) alignment 
Range on Protein: 282-387
Range on HMM: 187-288/302.0
HFRDWPVGSVPRSTGAFLDYWKEINAKTKETsSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNvlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLE
..  |.. .|| . ..     ... ||. .. . ....  . |.|| |||..    . . . . .    ..| .|.|.|.||| .|... ||  .| .| 
vltnWkqkkvpvkyaeliktaakvfakkika.dentvivSknGaGRagafltlavaveklqkgkep...nikeivksiRsqRpravdslkQyvslyiall

KYEKND
 | |. 
lyikkk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 310-384 9.3e-15 49.2 In-house 258-344 (350) alignment 
Range on Protein: 310-384
Range on HMM: 258-344/350.0
KETSSRPMIVHCNDGIGRTGAFIAIDSLLR--------QKEVKG----NNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYE
..  | |..|||  |.|||| ....||||         .|| .     ...   ....|  |||||  |||.  |. .||. |  | 
dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_CG42327_pd Subfamily CG42327 310-385 2.9e-14 47.5 In-house 243-316 (319) alignment 
Range on Protein: 310-385
Range on HMM: 243-316/319.0
KETSSRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVlgEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKYEK
.. |  |..||| ||.||||  || |  .|. |   . |  ..  || |.|..|   |.|  || .||.|| .| |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsv..diPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 311-383 3.1e-10 33.9 In-house 262-343 (349) alignment 
Range on Protein: 311-383
Range on HMM: 262-343/349.0
ETSSRPMIVHCNDGIGRTGAFIAIDSLLR-----QKEVKG---N-NVLGEMKVLVESLRKQRPGMVQTALQYRYIYQVLEKY
.  . ...|||  | |||| .. .|.||      |.|      .      . . | .|||||  |||   |.  ||. | ||
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 314-380 1.6e-10 35.3 In-house 228-292 (297) alignment 
Range on Protein: 314-380
Range on HMM: 228-292/297.0
SRPMIVHCNDGIGRTGAFIAIDSLLRQKEvkgNNVLGEMKVLVESLRKQRPGMVQTALQYRYIYQV-L
. ...|||  |.||.|  .  | .| .     .. . ... ... ||.||. .|||  |. ..|.. |
nayllvhcsaGvGrsGvvvlsdvilaklr...kkripdvaailsilreqrarlvqtleqfellydavl
subfamily_DSP23_pd Subfamily DSP23 315-380 3e-06 21.9 In-house 85-142 (148) alignment 
Range on Protein: 315-380
Range on HMM: 85-142/148.0
RPMIVHCNDGIGRTGAFIAIDsLLRQKEVKGNNVLGEmkvlvesLRKQRPGMVQTALQYRYIYQVL
  . |||  | ||||...|   |......   . . |       .|..||| |.|  | . ...  
eavsvhcllgrgrtgtmlacy.lvkerklaaaeaiae.......vrrlrpgsvetveqeklvrdye
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 317-380 1.5e-08 28.9 In-house 1-61 (69) alignment 
Range on Protein: 317-380
Range on HMM: 1-61/69.0
MIVHCNDGIGRTGAFIAIdsLLRQKEVKGNNvLGEMKVLVESLRKQRPGMVQTALQYRYIYQVL
|.|||  | ||||.||||  ..    .| .  | ..   |  .|| || ||    .| .|.  |
mvvhcssgtgrtgtfiai..mvemariksek.lvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 318-380 7.8e-08 26.6 In-house 1-60 (69) alignment 
Range on Protein: 318-380
Range on HMM: 1-60/69.0
IVHCNDGIGRTGAFIAIdsLLRQKEVKGNNvLGEMKVLVESLRKQRPGMVQTALQYRYIYQVL
.|||. | ||||.||||  ..    .| .  | ..   |. .|| || ||    .| .|.. |
vvhcssGtGrtGtfiai..mvemariksek.lvdifnnvqymrkcrpmmvmneneymfihdal