Gene PTPN6-5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP056_AA protein Get Run
AqueP056_AA_221-510 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 7-82 3e-20 62.7 Pfam-A 2-77 (77) alignment 
Range on Protein: 7-82
Range on HMM: 2-77/77.0
YHPNLAGgSEAEALLQDKGFEGSFLIRPSINSPGNYTLSAKRADKTVHVRIQNQGEF-YDLYGGEKFATLSELVEYY
|| .. . .||| ||.... .|.||.|.| ..||.|||| .. .|  |.|||.. .  | . ..||| .|.||||.|
yhgkisr.eeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
SH2 SH2 domain 114-190 7.7e-24 74.2 Pfam-A 1-77 (77) alignment 
Range on Protein: 114-190
Range on HMM: 1-77/77.0
WYHSGIDGKMAEDLLNSRGVTGSFLIRNSMRTPGSYVLSVRAIDEITHIMINVNTSGKFYVNEKYCFDTLKELIAYY
|||  | .. ||.||....  |.||.| | ..||.|.|||.  ....|. |. ...||.|..|.  |..|.||. .|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
0050432 (Phosphotyrosine protein) phosphatases II 207-512 7.1e-96 316.4 In-house 12-302 (308) alignment 
Range on Protein: 207-512
Range on HMM: 12-302/308.0
KPFVSTSFLPKFIPQRVSELEKPSGFSFGKSGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLldpPvPDETYINASYVSGEVPG
 .|..||.|.......| .| |     .......||||||...      ..... .||||.|||.|.|.||| . | |   . .. .|||||||.| . .
llfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl...d.egsdYInAsyvdgyssk

SENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTID-DEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYK
... .||.||.|..||.|||.|.|..|.|||||.||..|..||||..|||.... . ..|| . |.|. |. .  |..|...... ||. .| |...||.
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhyt

SWPDHGVPQDPGLFLGFIEDVNRKIkdfeePGqtsGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQI
.|||||||..|  .| |.| |....     ||   ||||||||||.|||||.|. |.|. ..|..    ..|... ...||| | ||||| .||. .|..
nWpdhgvPpspeilldflelvrksl.....pg...gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyra

ISYYIQIR
. .|.. .
lleylklk
subfamily_PTPN6_pd Subfamily PTPN6 212-516 5e-141 464.1 In-house 2-304 (306) alignment 
Range on Protein: 212-516
Range on HMM: 2-304/306.0
TSFLPKFIPQRVSELEKpSGFSFGKSGFFEEFEELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVPDETYINASYVSGEVPGSENCY
||.|.| | |||||||| .. |..|.|| |||||||. ... . ||| | ||||| |||.|||.|.|.| |.| .| ||...||||.|...||.||...|
tsllakeieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksy

IAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMiYGEVNVKLVAEKGQFQYILRQFRVC--KGDETERSVHQYHYKSWPDH
||.||||..|| |||.|.||||||||||.|||.||..|||.||||.. ..|. ||...|. |.|| . .||||...|.  | ...||.|.|||.||||||
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdh

GVPQDPGLFLGFIEDVNRKIKDFEEPgqTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
|||.||| .| |.|||||| ...||   ..||||||||||||||||.|..|||.||||..|.||.||||.... .||.|||.|||.||||.||..|..||
gvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

QIREKLL
. ..|| 
etkkkle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 221-518 9.1e-82 269.6 In-house 9-289 (318) alignment 
Range on Protein: 221-518
Range on HMM: 9-289/318.0
QRVSELEKpsgfsFGKSGFFEEFEELQKIDSMFRKSRKigVKPENKPKNRFKNIVPYDDTLVTLLDPP-VPDETYINASYVSGEVpgSENCYIAAQGCLQ
..| .|..      |.  ..||.|.|.. .. . . .   ..| || |||. ||..||.| | | .   ...  ||||.|. |    ... |||||. | 
shvrrlre.....sGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr..rkkayiaaqaPlp

STVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQDPGLF
 |. ||| |.|. ||.||||.|.|.|| ..|. |||||  .. . ||.. |.|  |.   .|.||.|.| . . | .| |.|||| ||||.|||.... .
etieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasl

LGFIEDVNRKIKDfeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLSA
| .. .|..  ..     .. ||||||||||.||||..|. |||.. |.    .| .|. | ...||| |  ||||..||...|...  ...  ..  .|
ldlvrqvskaqqk.....sgagpivvhCsaGvGrtGvfiavdillerika...ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda
0045450 (Phosphotyrosine protein) phosphatases II 230-509 8.6e-89 293.6 In-house 20-304 (307) alignment 
Range on Protein: 230-509
Range on HMM: 20-304/307.0
SGFSFGKSGFFEEFEELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV--PDETYINASYVSG------EVPGSENCYIAAQGCLQST
     ...|...|||.|...  ..  ...|. .||||.|||.|.|.|||.| | | ...   .|  |||||||        ... . . .||.||.|..|
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK--GDETERSVHQYHYKSWPDHGVPQDPGLFL
| |||.|.|.....||||.|...|..||||..|||.. ..|. ||.. |.|. |. .  |..|...|    |.. .| |...||..|||||||...  .|
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

GFIEDVNRKIKDFeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
 ||| |.. ...     . .||..||||||.|||||.|. ... ...|..|.   .|... ...||| |.|.||. .||. .|... ...
dfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 232-511 2.6e-63 208.7 In-house 15-280 (287) alignment 
Range on Protein: 232-511
Range on HMM: 15-280/287.0
FSFGKSGFFEEFEELQKIDSMfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLdppVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQ
   |. || . |  |....   ...  ... ..||.|||...|...|.  | |      .. ||||... |    ... .|.|.. . .|. .||..|..
hakgnegfknqftvleqvtqr.edevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgy..kekkafiiaesPmfntarnfWklidd

ENSRVIVMITKEMERNREKCYRYWPSTIDdeMIYGEVNVKLVAEKGQFQYILRQFRVCKGD--ETERSVHQYHYKSWPDHG-VPQdPGLFLGFIEdvnRK
.|  .|||...|.| ..|.||.|||..    ...|| |..|. |. . .|| |...| . .  .....|.||.. .|...| |.. |   |  ||   ..
rnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvte.pqtillvie...em

IKDFEEPGQtsGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQI
.|    .|.  ..||||||...||.....  .. ..  . .|    ||. | ... |  . |.||| .|||....|.  |.. 
yktqrkrgn..tsivvhCsdtvGrsamfcaaattinkckteG...viDvfqvlksqriqkpgsvqtveqykfindivleylds
0039614 (Phosphotyrosine protein) phosphatases II 233-512 2.1e-84 278.8 In-house 28-292 (297) alignment 
Range on Protein: 233-512
Range on HMM: 28-292/297.0
SFGKSGFFEEFEELQKIDSmfrkSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPP--VPDETYINASYVsgEVPGS-ENCYIAAQGCLQSTVGDFWHMI
 ..|.....|||||...      ...|. .||||.|||.|.|.|||.. | | ...  ..| .|||||||  ...    . .||.||.|..||.|||.|.
ansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedFwrmv

WQENSRVIVMITKEMERNReKCYRYWPSTIDdemIYGEVNVKLVAEKGQFQYILRQFRVCKGDETeRSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKI
|.....||||.||..|..| ||..|||.. .    ||.. |.|. ..    |..|...| ...|. | |....| .|||||||... |.| |.| |.. .
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges.rtvthfqytgwpdhgvppslellleflelvreal

KDFeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIR
.      . .||..||||||.|||||.|. .... ..|.     ..|... ...||| |.|.|||..||. .|... .... .
ael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRG_pd Subfamily PTPRG 233-524 5.2e-70 231.2 In-house 15-302 (563) alignment 
Range on Protein: 233-524
Range on HMM: 15-302/563.0
SFGKSGFFEEFEELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVPDET--YINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIW
. |. || ||||.||.         .   ||||| |||  |||.|| . |.| . |  ...  ||||.|. |     .. .||.|| |..|. |||.|||
adgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq..kskafiatqgplkdtfddFWrmiW

QENSRVIVMITKEMERNREKCYRYWPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRV-----CKGDE--TERSVHQYHYKSWPDHGVPQDPGLFLGFIE
..|. .|||||.  ||.|.|| .|||.  |. . ||...|.|..|.    |  |.. .      |...  ||. | |||| .|||||||. .   | |..
eqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

DVnrkikdFEEPGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLSAASSEN
             .. ||||||||||.|||||||. | |.| |. .     ... . ....|  |  .|||  ||  .....   |. .|. |.|   |.
ks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee

L
|
l
0051299 (Phosphotyrosine protein) phosphatases II 234-509 2.1e-90 298.4 In-house 20-286 (288) alignment 
Range on Protein: 234-509
Range on HMM: 20-286/288.0
FGKSGFFEEFEELQKIDSMfrKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGevPGSENCYIAAQGCLQSTVGDFWHMIWQE
 |..|..||||||...  .   .......|||..|||...|.|||.. | | ...  .. .||||||..|  . ... .||.||.|..||.|||.|.|..
ngltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvweq

NSRVIVMITKEMERNREKCYRYWPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-----GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNR
|.|||||.||..|..||||..|||.  .. ..||.. |.|. |. .  |..|...| .     ||...| |...||..|||||||..| |.| |...|..
nvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

KIKdfeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
...      ...||.|||||||.|||||.|. |.|. ..|..    ..|. . ..|||| | ||||| .||..||... .|.
ala......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 234-512 3.6e-90 297.5 In-house 10-280 (297) alignment 
Range on Protein: 234-512
Range on HMM: 10-280/297.0
FGKSGFFEEFEELQKIdsMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLldpPVPDETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQEN
...... .|||||...  ..  |.... .|||..|||.|.|.|||.| | |   . ..  |||||||  .... .. .||.||.|..||.|||.|.|..|
lflalllkefeellpl..lllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqn

SRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKG--QFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIK
..||||.|...|..||||..|||....... ||.. |.|. ..      |.||...| . |.. .| |...||..|||||||..|  .| ||| |....|
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

DFeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIR
 .      .||..||||||.||.||.|. |... ..| .    ..|| . .. ||| | |.||| .||. .|... .... .
ll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 234-513 4e-71 234.7 In-house 20-287 (319) alignment 
Range on Protein: 234-513
Range on HMM: 20-287/319.0
FGKSGFFEEFEELQKIDSMfrkSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQE
 |. .. .||..|.. ...   . .   |.|||.|||..||..|| | |.| . . |.. .|||||.. |     .. .||.|. |. |. ||| |.|.|
tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlentiedfWrmvWee

NSRVIVMITKEMERNREKCYRYWPSTidDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDET--ERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIK
.| ..||.||  |. . |. .|||..  . . ||.. |.|  |. . .|| |.. . |  .    |.| ...|..||||.||..  . | .......  .
essivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre

dfeepGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
     ...|||||||||||.|||||.|. |. .  ..    .. .|. . ..|||  |  |||. .|||..|...  .... .
.....ktqsgPivvhCsaGvGRtGtfivldamlervke...egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 234-511 8.2e-67 220.1 In-house 17-285 (290) alignment 
Range on Protein: 234-511
Range on HMM: 17-285/290.0
FGKSGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PD--ETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIW
 |..|| ..|. |.. .|   .. ..|. ..||..|||.|||.|||  .|| . .  .|  . ||||.|. |     .. |||.|| ...|. |||..||
kgnegfrnqfkmldsges..ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy..kekkqyiatqgpvsntlvdFWkliw

QENSRVIVMITKEMERNREKCYRYWPSTiDDEMiYGEVNVKLVAEKGQFQYILRQFRVCKGDE--TERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNR-
||.. .|||.|...| ...||. |||.. | .. |||...||. |.   .|| |...| . ..  ...||.||. ..|...|  ..|   |  || ... 
qekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

KIKdfeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQI
. |      .. ..||||||...||..... ... ..  . .|    ||. | ....|  . |.||| |||....||.  |.. 
qrk......rgntsivvHCSdtvgrsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN23_pd Subfamily PTPN23 234-508 8.8e-67 219.9 In-house 12-279 (288) alignment 
Range on Protein: 234-508
Range on HMM: 12-279/288.0
FGKSGFFEEFEELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLdppVPDETYINASYVSGEVPGSeNCYIAAQGCLQSTVGDFWHMIWQEN
 ||... ..|.||.. .    ..| | .   .  |||...|.||| . |.|       . |||||.| . .||.  ..||.|. ||||..||| |.... 
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgc.PdfiatqaPlqstlnDFWlmvyeqk

SRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVC-KGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDF
|.||||.... |....|. ||||.  .. . .|...| |  ..   ... |....  .. .. .||   ...|||..|||. |. .| |.. |. . .  
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

EEPGQTsgPIVVHCSAGIGRTGTYIITDILVKLIeYQGwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYY
... .|  |.|||||||.||||.. .    |. . ..| .  .|| | ..|||| |  |||. .|.|..|...  .
qrkskt..PlvvhCsaGvgRtgvfalvyaavrel.ekg.nglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0047943 (Phosphotyrosine protein) phosphatases II 235-509 3.9e-87 287.5 In-house 10-272 (273) alignment 
Range on Protein: 235-509
Range on HMM: 10-272/273.0
GKSGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLldpPVPDETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENS
|.....||||.|...      .......|||| |||.|.|.|||.. | |   . ..  |||||||  ... ... .||.|| |..||.|||.|.|..|.
gltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvweqnv

RVIVMITKEMERNREKCYRYWPSTIDD-EMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDF
|||||.|...|..||||..|||.. .. ...||.. |.|. |.    |..|.... . |.. .| |...||..|||||||...  .| |||.|..... .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

EEPgqtsGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
 ..    ||.|||||||.|||||.|. |.|. ..|. |   ..|. . ...||. | ||||| .||...|... .|.
psn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 235-509 6.4e-85 280.2 In-house 18-277 (278) alignment 
Range on Protein: 235-509
Range on HMM: 18-277/278.0
GKSGFFEEFEELQKIDSmfrKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQEN
.|... .|||||....     ...|. .||||.|||.|.|.||| ..| | . . ..| .|||||||  ...   . .||.||.|..||.|||.|.|...
lktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelg

SRVIVMITKEMERNREKCYRYWPstiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdf
...|||.|...|..|.||..|||   .. . ||.. |.|. |. .  |..|...| . ||  .| |..|||..||||||| .. |.| |...|.....  
vttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..

eepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
      .||..||||||.|||||.|. ..|. ..|. |   ..|... ...|||.| |.|||..||...|... .|.
....dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 235-506 1.3e-78 259.0 In-house 19-276 (288) alignment 
Range on Protein: 235-506
Range on HMM: 19-276/288.0
GKSGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQEN
...|| ||.. | ....   || ..| ...|..|||..||.||| . | | . . .... ||||||. ||  .... |||.|| |..||.|||.......
nrtgfseeynsLaalek..tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelvyenk

SRVIVMITKEMERNREKCYRYWPSTiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKgDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFe
.  |||.|. .|....|| .|||.. |..  ||.|.|.|| .| . ...||.. . | ..||. ..||.|..|||||||..   .|.... |.   ..  
tstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllek.kkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.

epgqtSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIIS
     .|||.||||||.|||||.|  | |.. .|    .  ||.   . .||. |  .||| .||  .|... 
.....tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN12_pd Subfamily PTPN12 235-510 1.4e-77 255.5 In-house 6-278 (290) alignment 
Range on Protein: 235-510
Range on HMM: 6-278/290.0
GKSGFFEEFEELQKIDSMFRKSR----KIGVKPENKPKNRFKNIVPYDDTLVTLL-DPPVPDETYINASYVSGevPGSENCYIAAQGCLQSTVGDFWHMI
|.  | .||..|.|. . .....    . | |.||. |||.|.|.||| . |.|  .  .... ||||... |  . ..  |||||| |  |. |||.||
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..vegkleyiaaqgPLpktlddfWrmi

WQENSRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQF-QYILRQFRVCKGdETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRK
|. | ...||. .|.| .. || ||||.. ..|. .||..|.| .||    ....|...| .  ...|.|.|.||..|||||||. .   | .||.|.. 
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrel

IKdfeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
 .      . . |.|||||||.||||| |  |.  .|.. .  . |.|. . ...||. |. .||| .||..||. .  ..|
qe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 235-510 3.2e-69 228.4 In-house 25-291 (298) alignment 
Range on Protein: 235-510
Range on HMM: 25-291/298.0
GKSGFFEEFEELQKIDS-MFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQE
. .|. .||..|... | . ... ... ||||| |||. .|...| . | | .     . .|||||....     .| .||.|. |..|| |||.|...|
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhayk..grnafiatqaPltetvedFWrmvtee

NSRVIVMITKEMERNREKCYRYWPSTidDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKD
.. .|||.|.  | .. |. .|||..   .  |||..|.| ... . ..| |.. | | . |.||.|.| |. ||||.|||.     |.....|... ..
digtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqq

feePGQtsGPIVVHCSAGIGRTGTYIITDILvklIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
    |.   |..|.||||.||.||.|. | .   .|    .  .|. | ...||. | |.||| .||. .|...  ...
...agn..kpvivqCsaGvgRsGtfiaidsv...lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN9_pd Subfamily PTPN9 235-513 6.5e-63 207.5 In-house 14-294 (297) alignment 
Range on Protein: 235-513
Range on HMM: 14-294/297.0
GKSGFFEEFEELQKIDSMFRKsrKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVPD-ETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQEN
||.|  .|..|...     .   .   .. |  |||..... ||.| |.|   .  .   ||||..| |     ....||.|| |. || ||| |.|...
gkrGlskeyaeirnepveGtf..lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvWeqe

SRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDF
 .||||.|. .|| | || .|||.. .. . .|...|. |  . . .|  |.. . .  .| .|.|  . . ||||.|||..   .| ..| | .|   .
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqala

------EEPGQTSG-PIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
      |. |..|| |||||||||||||||.|  || .. .| .|    .|.......||. |. ..||..||.. |. .  | . ..
vkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
0040438 (Phosphotyrosine protein) phosphatases II 236-531 3.4e-90 297.8 In-house 17-298 (317) alignment 
Range on Protein: 236-531
Range on HMM: 17-298/317.0
KSGFFEEFEELQKIDSMfrkSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPP-VPDETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENS
. .. ||||.|....     ..... .||||.|||...|.|||.. | | ... ..| .|||||||  ..|   . .||.||.|..||.|||.|.|....
ftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvweqgv

RVIVMITKEMERNREKCYRYWPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdfe
.||||.|...|..||||..|||.  .... ||.. |.|. |.    ..||...| . ||...| |...||..|||||||..| |.| |.| |.....   
tvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...

epgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLSAASSENLYDQVDAP
   . .||..||||||.|||||.|. .... ..|. |   ..|... ...|||.|.|.||| .||. .|... .|.. ...| .| .  .....  .|
...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 236-510 1.7e-72 238.9 In-house 14-277 (281) alignment 
Range on Protein: 236-510
Range on HMM: 14-277/281.0
KSGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLL-DPPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENS
..|| ||.|.|..|.   ... .   ..||. |||..||| || | |..  .    .  ||||..|.|    .|. |||.|| . ... .||.|.|... 
naGfieeyeklaaigv..dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk..gekeyiatqgPvPaslvafWqmvweqkv

RVIVMITKEMERNREKCYRYWPsTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfee
..|||.|.|.| .. ||.||||   . |..||.| || .||. . .|| |.|.. . .  .|.|.| .|..|||||||...  .|.| ..|..  .    
saivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltek...

pgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
  .|  |.|.|||||.|||||||  | ||| .| .   .|.|... .. ||. |  ||||  ||. ||...  ...
..ktkaplvihCsaGvGrtGtyialDrlvkaveae..leeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 236-509 8.1e-61 200.9 In-house 22-288 (325) alignment 
Range on Protein: 236-509
Range on HMM: 22-288/325.0
KSGFFEEFEELQKIDSmfrKSRKIGVKPENKPKNRFKNIVPYDDT---LVTLLDPpvPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMI--W
. ||  ||. |   |.   ...|. .||||| ||||||.|..| .   |.|. |   |.  ||||||.  ..    . ..|||  | .|..|.| ..  |
qdgfahefgllpsddg...iakkvamkpenkaknrfknvvaldksrvvletkkdd..pssdyinasylrddk..kkdvflaaqaPltatindlWrlvldW

QenSRVIvMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDET-ERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKI
.  . |. ... |.. . ..|  |||  . .   .| ..|||.. .    |. |.. | . ..   |||.|....||.| ||.. |  .. ... |.   
r..csvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

KDFEEPGQTSGPIVVHCSAGIGRTGTYI-ITDILVKLIEyqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
.      ..|.||.||||||.||||..| .  .| |.||    ....|| .....||. |  ||.|  || ..|. .  ..
ervtantkastpilvhcsaGvGrtGvfislysalakvie....esrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRB_pd Subfamily PTPRB 237-512 1.1e-80 265.8 In-house 25-288 (293) alignment 
Range on Protein: 237-512
Range on HMM: 25-288/293.0
SGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSR
 .| ||.|||.....   .. |.  ...|. |||..||.||| . | | .    ... ||||.|..|    |.. .||.|| | .|| |||.|.|...|.
lrfseeyeelkavgk..dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwekkss

VIVMITKEMERNREKCYRYWPSTIdDEMIYGEVNVKLVAEKGQFQYILRQFRVCKgDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfeep
.|||.|. .|. ..|| .|||..  ....||...|.||||. . ....|.....| ...||.|.|||..||||||||...  .| |.. |...|..    
iivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek....

GQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIR
 ....|||||||||.|||||.|  | |.. ||    .  .||   . .||| |  .||| .|| ...| .  ... .
taskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPN14_pd Subfamily PTPN14 237-510 4.2e-69 227.8 In-house 23-297 (300) alignment 
Range on Protein: 237-510
Range on HMM: 23-297/300.0
SGFFEEFEELQKIDSmfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVPDETYINASYVSGEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRV
.  | |.|...|         . .  |||..|||||...||.|. | |      .. ||||| ..  | |.|  ||.||| |. || |||.|.|... ..
gkvfteyeripkkre..dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMITKEMERNREKCYRYWPST--IDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVN---RKIK
|||.|.| |  .||...|.|..    ... .|. .|     .   ..| .....     . ||.|.   |. |||||||.|.  || ..|.|.   || .
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

DFEEPGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
.  |. ... |..||||||.||||  |..|.|.. .|    . ||||.....|||| |  .|||  |||.||...  |..
seveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Ptp69D_pd Subfamily Ptp69D 237-511 3.1e-68 225.2 In-house 22-288 (307) alignment 
Range on Protein: 237-511
Range on HMM: 22-288/307.0
SGFFEEFEELQKIdsMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVPD-ETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSR
 |. .|.|.|..   .. || |.. | ||. |||...|...|.| | |   .  .  .|||||.. |     .. .||||. ...|.|||| ||.. .. 
fglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmiaeqevt

VIVMITKEMERNREKCYRYWPSTidDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGD------ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKI
.|||.... | ||.|| .|||    ||. ||...|||| |. . .|| |.. | | .      | .| | ||||..|.|  ||. .   | .|| |.   
livmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

KDFeepgqtSGPIVVHCSAGIGRTGTYIITDILVKLIEyqgWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQI
|         .||||||||| ||.|...  |.|.. ..    . ..|| . .. ||. |. .||  .||. .|. .  |.. 
kln......rsPivvhCsaGvgrsgifvaldsllqqlk...aedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 237-519 1.8e-40 133.6 In-house 22-296 (305) alignment 
Range on Protein: 237-519
Range on HMM: 22-296/305.0
SGFFEEFEELQKIDSmFRKSRKIgVKPENKPKNRFKNIVPYDDTLVTLlDPPVPDEtYINASYVSgeVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRV
 |. .||  .....  | | . .  . ... |||.|..   |.  | | ..| | | || | |||   |   . .| .|  |. |  |||.| .|..   
aglraefvamkrfnd.fekmkaf.keaqeagknrykdvgcldnnrvkl.egpwphe.yihanyvs..tptnpkrfictqaplektcadfwymclqdkvea

IVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAE-----KGQFQ-----YILRQ-FRVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDV
| |. . .|.  .||. |..|  .|.. . | . |..       . .|.      . .  . .    |. | | .||.  ||| |||      | ..|. 
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka

nRkikdfeepgQTSGPIVVHCSAGIGRTGTYIITDI-LVKLIEYQGWDaeiDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIReKLLSAA
 |          . |||||||||||||||. .. .  | .|.. |  .   | .. ....|| |   .|||.|| .|.|.|  |.. . |||  .
.r.........pskgpivvhcsagigrtgsvvmleyildqllagqiie...dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk.klldee
subfamily_CG42327_pd Subfamily CG42327 237-431 2.4e-32 106.9 In-house 5-196 (319) alignment 
Range on Protein: 237-431
Range on HMM: 5-196/319.0
SGFFEEFEELQkidSMFRKSRkiGVKPENKPKNRFKNIVPYDDTLVTLLDPP-VPDETYINASYVSGEVpGSENCYIAAQGCLQSTVGDFWHMIWQENSR
.  .|||..|     .  ..    | .  |.|.|. |.||  .| |.|   .  . . |..|||| |    ..| |||||  |...  ||| ..|. .||
edvaeefrdlP...qliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsr

VIVMITKEMERNREKCYRYWPS--TIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDE-TERSVHQYHYkSWPDHGVPQDPGLFLGFIEDVNRKIKD
||| .|.  |   ..| .|.|.  | |..  ||.. | |   . . .|..  . . . |.   | .  | |  |.. .|| ..  ..  . .|.  .| 
vivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks
0046845 (Phosphotyrosine protein) phosphatases II 238-513 3.2e-93 307.5 In-house 1-278 (284) alignment 
Range on Protein: 238-513
Range on HMM: 1-278/284.0
GFFEEFEELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV--PDETYINASYVSGEVP---GSENCYIAAQGCLQSTVGDFWHMIWQE
|..||||||...  ..  |......|||. |||.|.|.|||.. | |  ..   .| .|||||||.|       ... .||.|| |..||.|||.|.|..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSRVIVMITKEMERNREKCYRYWPSTiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKG--DETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIK
|.|||||.|...|..||||..|||.. .. ..||.. |.|. |. .  |..| ... .   .. .| |...||.||||||||..|  .| |...|.. ..
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

DfeepGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
.      ..||||||||||.|||||.|. |.| ...|..|.....|... ..|||| | ||||| .||..||... .|.. . 
n....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 238-523 1.4e-69 229.5 In-house 33-309 (330) alignment 
Range on Protein: 238-523
Range on HMM: 33-309/330.0
GFFEEFEELQKidSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRV
 | |||. |    .  . . ..  | ||| |||. ||.||| . | |     |..  |||||.. |      . .||||| .. || ||| |||. .|  
lfreefnalPa..gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksat

IVMITKEMERNREKCYRYWPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVC-KGDET----ERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKd
|||.|.  ||..|||..|||.  .  . ||...|..  |.   .| .|.| |  ..|.|    .| |.|.|..|||| ||| .|   | ... |... . 
ivmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq.

feepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLSAASSEN
     |..||||||||||.|||||.|. | ... ..    .  .|. . ..|||  |. |||||.||...|...  |    .  | ..| |.
.....qsagpivvhcsaGvGrtGtfivldavlervka...erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek
subfamily_PTPRK_pd Subfamily PTPRK 238-507 2e-66 219.0 In-house 23-275 (314) alignment 
Range on Protein: 238-507
Range on HMM: 23-275/314.0
GFFEEFEELQKIdsmfrksRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRV
|| ||.| | .             | ||. |||...|..|| ..|.|      |.  ||||... .      . .|..|| ||.|| ||| ....||.  
gfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydencas

IVMITKEMERNREKCYRYWPstiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK---GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfe
|||.|. .|  | ||..|||   .| ..||...|.||  . . ... | |||.|   | |  | |.|... .||||.||.    .|...  |. . ..  
ivmltelvevgrvkClkyWP...edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..

epgqTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWdaeIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISY
    . |.|||||||| |||||.|. ||.. .|| .|    .|. . .. ||. .. ||.| .|||..|..|  
....eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPRD_pd Subfamily PTPRD 239-519 2.2e-89 295.6 In-house 25-291 (564) alignment 
Range on Protein: 239-519
Range on HMM: 25-291/564.0
FFEEFEELQKIdsmFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
|.||......     . . .   ||.||.|||..|||.|| . | |   . ...  |||||.. |    ... |||.|| |..|. ||| |.|..||..|
feeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnssti

VMITKEMERNREKCYRYWPSTiDdEMIYGEVNVKLVAEKGQFQYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdfeepg
||.||  |....|| .|||.. . .  |||. |.|..|.   .|..|.|.. | . .  | |.|.|. ||||||||. .  .| .|..|..  .      
VmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne......

QTSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLSAA
...||||||||||.|||||.|. |.... |..   .. .|| | ...||. |  |||| .||  ....|  ...  .. ... 
pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevese
DSPc_SM00195 239-510 1.7e-85 281.9 In-house 2-263 (263) alignment 
Range on Protein: 239-510
Range on HMM: 2-263/263.0
FFEEFEELQKIDSMFrkSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
. ||||.|.. .|    . . . |..|| |||.|||.|||.| | | ...  ....||||.|..|.   ... |||.||.|.||| |||.|.|.|....|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkii

VMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQF-QYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFeep
||.|.|.|...|||.||||....... .|...|||| .. .  ..|||.... | . |..|.|.||.||.|||||||...  .| ... |. . .     
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...

gqtSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWdaeIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
   |||||||||||.|||||.. .||... .| .     .||.. ...||. | |||||..||...|..| .||.
...sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 239-510 1.7e-85 281.9 In-house 2-263 (263) alignment 
Range on Protein: 239-510
Range on HMM: 2-263/263.0
FFEEFEELQKIDSMFrkSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
. ||||.|.. .|    . . . |..|| |||.|||.|||.| | | ...  ....||||.|..|.   ... |||.||.|.||| |||.|.|.|....|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkii

VMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQF-QYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFeep
||.|.|.|...|||.||||....... .|...|||| .. .  ..|||.... | . |..|.|.||.||.|||||||...  .| ... |. . .     
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...

gqtSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWdaeIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
   |||||||||||.|||||.. .||... .| .     .||.. ...||. | |||||..||...|..| .||.
...sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 239-517 2.3e-61 202.4 In-house 21-285 (315) alignment 
Range on Protein: 239-517
Range on HMM: 21-285/315.0
FFEEFEELQKIDSMfrkSRKIGVKPENKPKNRFKNIVPYDDTLVTL-LDPPVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
| ||| .|   |      .... ...| .|||.|||.|.| . | | .    ||. ||||||. .    ....|||.|| |...| |||.|..||.   |
fseefhdlpdPdiy...rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksv..dddkayiasqgPlkasvddfwrmvlqekvtti

VMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFrVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKikdfeePGQ
||.||  | .. || .|||    | . .|...|.|.  . . . . |.. | .  |. | | |.... |||.||... . .| .| .|  .       |.
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad......ngk

TSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLS
   ...||||||.||||  |  |  |. |. .     .|. . .. ||. |  .|||...| ..|...  ... |. |. 
kefsllvhcsaGvGrtGvvisidevvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlil
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 239-506 6.5e-50 164.8 In-house 22-276 (439) alignment 
Range on Protein: 239-506
Range on HMM: 22-276/439.0
FFEEFEELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTL-LDPPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
| |.||... ..  ..    .  .  ...|||.|.....| | |||   | ||   |||| |. |     .. |||.||  . |. ||| .......  |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy..ddklyiatqgpkkettddfwrlviekktvti

VMITKEMERNRekcyrYWPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKG---DETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKiKDFEE
||.|. .|  .     ||||  |.|..||.. |.   .    .|..| |.| .     | ||.| |.|| .|||. || .    | |.  .|   .| ||
vmltnlvesyk.....ywps..daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa.ndkee

pgqtSGPIVVHCSAGIGRTGTYIITDILVKLIEyqgWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIIS
     ||.|||||||.||||| |  || .. .     . ..||.  .. ||. |  |||.  || ..|. . 
....ygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 239-516 3.2e-46 152.5 In-house 22-243 (392) alignment 
Range on Protein: 239-516
Range on HMM: 22-243/392.0
FFEEFEELQKIDSMfrkSRKIGVKPENKPKNRFKNIVPYDDTLVTL-LDPPVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
||||| .|   | .    .... |. |..|||.|||.||| . | | .   .||. |.||||. .    .|..|||.||   ... |||.|..|||   |
ffeefhdlpgpdiy...pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqenvtti

VMITKEMERNrekcyrywpstiddemiygevnvklvaekgqfqyilrqfrvcKGDEtERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkdfeepGQ
.|.||  | .                                          |||.  |.| |.|.  |||..||.    .| ||..|. .       ||
amvtklkegd..........................................kgdd.artvaqfhftewPdkdvpkhtssllkfikevkadf......Gq

TSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLL
 . |...|||||.||||  |  | .|   .       .|. . .  .|. |  ||||..|| ..|  .   .  |. |.
ythpliihcsagvgrtgvvisidsvvahakk...trmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntli
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 239-512 2.1e-38 126.9 In-house 8-262 (267) alignment 
Range on Protein: 239-512
Range on HMM: 8-262/267.0
FFEEFEELQKIDSMFRK-SRKIGVKpeNKPKNRFKNIVPYDDTLVTLLDPpvpDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVI
. .|||...|| .   . |  |. |  |. .||. . .||||| | | .    .| ||||||| |     .| .|. |. |. |..||. .| ...  ||
iekefelikkisdtsstisqsiaek..nqernrlddnlpyddtrvilrtk...eeeyinasyvegyk..tknafivtqdplkntitdfltvihdqkvpvi

VMITKEMERNrekCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETERSVHQYHYKSWPDHgVPQDPglFLGFIEDVNRKikDFEEPGq
|..||  . |     ..||  . .   | .. |.   || . .| .  . .   .|. . |  |.|| |    . . |  .|  .  .  |  .  | | 
vlltkvftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.tnnkp..ylkplfgilak..nqleng.

tSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIR
 . |.||.||.|.||.||... |  .. .     .   || . .|..|. | |.|.| ..|  ...... | . |
.nrPlvvacsdGvGrsGtflvidsqlerakt...egvsdifdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_PTPN13_pd Subfamily PTPN13 241-507 7.9e-68 223.7 In-house 15-267 (273) alignment 
Range on Protein: 241-507
Range on HMM: 15-267/273.0
EEFEELQKIDSMfrKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVpdetYINASYVSGEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMI
|||.||... ..  .. ..| | ||| |||..|..|||.| |.| |       |||||..  .|   |  |||.|| |  || ||| |.|. ...||.|.
eefkelrelkpl..dtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TKEMERNREKCYRYWPSTIDDE-MIYGEVNVKLVAEKGQFQYILRQFRVCKGDET-ERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVnRKIKDfeepgqT
|.| |... || ||||.. ... .... ..|.|.  . . .. .|.. | . . .  | | . .. .|||||||. .  .| |.  | |....       
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaev.rrlqt......d

SGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISY
.|||||||||||||.||.|  |... ||| .    |.|... .|.||| | |.|||..|| .||..| .
agPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 242-504 3.3e-61 202.3 In-house 39-286 (319) alignment 
Range on Protein: 242-504
Range on HMM: 39-286/319.0
EFEELQKIDSMFRKSrKIGVKPENKPKNRFKNIVPYDDTLVTLlDPPVPDE--TYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVM
||  . |.     .  .    ..|| |||. ||...| . | | .. .  |   |||||.|.|    ... |||||| |. |. ||| |||. |.  ||.
efrracklgvnladq.tfanldqnkdknriinilafdknvvkl.erliGeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyncstivl

ITkemernREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQfqYILRQFRVCK-GDET-ERSVHQYHYKSWPDHGVPQDPGLFLGFIEdvnrKIKDFEEPGQ
.|      ..|| .|||  |. .   ..|.|..| |  .  |..|.... . | |.  |...|.|.. |||.|||. |  .. ...    |.. ...  .
lt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk....kvrhltsken

TSGPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQI
   .||||||||.||||.||. |.|.. ..    .  .|. . .| ||. |. .||   |||..|  
hranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 243-505 1.2e-47 157.1 In-house 12-262 (283) alignment 
Range on Protein: 243-505
Range on HMM: 12-262/283.0
FEELQKIdSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVpdeTYINASYVS-GEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMIT
.| |... |.  .. .| .  |||.|||...|||.|   | |   .    .||||...   .    .. ||.||. |. || |||.|...|.   |||.|
revlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

KEMERNREKCYRYWPSTIDDEmiYGEVNVKLVAEKGQFQYILRQFRVCKGDETERS--VHQYHYKSWpdhgVPQDPGLFLGFIEDVNRKIKDFEEpgQTS
| .| .|.|| .|||.    .  |||  | |  | ..  .| ... . .   .. .  .  | .  |    .  ...  .  .  .|. |    |  .  
klqedlrikCsqyWPkrGsed..yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqte..skk

GPIVVHCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
||||||||.|||||...|     || .     .. .|. . .. .|| | ..||| .|||.|....
gPivvhCstgiGrtavfiaasasvkdalt...esvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 244-513 1.6e-54 179.7 In-house 19-297 (301) alignment 
Range on Protein: 244-513
Range on HMM: 19-297/301.0
EELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV---PDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMI
|. ......  || ..|.. |||. ||||||..|||  ..|   |      ..||||||..|    ... .||||| ...|. |||..||||    |||.
eqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

TKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDE----------------TERSVHQYHYKSWPDHGVPQDPGLFLGFIED
|.. |. ..||..|||..  ..  .|...|.|| |.   ....||. |   |                 . ..| |..  .||..|| ..|   |  |.|
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

VnrkIKDFEEPGqtSGPIVVHCSAGIGRTGTYIITDILVkliEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
|   |.    .|   ||.|||||....|.|.|.  .| .   |    .  .|. | ....|  . |.|.| .|| ..|..|. |.|. .
v...ihrqqkig..ggpvvVHCSdtVsrsGvYcsvsigl...EQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 245-302 2e-07 24.7 In-house 27-85 (440) alignment 
Range on Protein: 245-302
Range on HMM: 27-85/440.0
ELQKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSG
|   . | . .  .|   |.|| |||..||. || . | | .   |||. ||||||..|
ewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_PTPN3_pd Subfamily PTPN3 246-505 4.9e-74 243.7 In-house 18-271 (280) alignment 
Range on Protein: 246-505
Range on HMM: 18-271/280.0
LQKIDSMFRKSRKI----GVKPENKPKNRFKNIVPYDDTLVTLLDPPVpDetYINASYVSGEVPGSENC--YIAAQGCLQSTVGDFWHMIWQENSRVIVM
|.. . ..|| ...      |||| .|||...|.|||.| |.| . .. |  ||||.||. |.|...    |||.|| |..|. |||.|.|...|..|||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.d..yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

ITKEMERNREKCYRYWPStIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkdfeepGQT
.|  .|| | ||..|||.  .||. ||| .||.  |. . .|.||.. ... . . ||...|  | .|||||||.|.  || |.| |...         .
lttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgk

SGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
. |.|||||||||||| .|. .. . ||| .    .. . . .|..|. |. .||| .|||.| . |
eePvvvhCsaGigrtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 247-316 8.9e-12 39.0 In-house 30-95 (95) alignment 
Range on Protein: 247-316
Range on HMM: 30-95/95.0
QKIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDppVPDETYINASYVSGEVpgSENCYIAAQG
. |      .  .|    | ||||| ||.||| | |.|      |  |||| .| |      ||||||||
ksismtsgapytvgsseanipknrflnifpydatrvvltt..krdsdyinacfvdgya..rkncyiaaqg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 248-512 1.2e-71 236.4 In-house 30-286 (305) alignment 
Range on Protein: 248-512
Range on HMM: 30-286/305.0
KIDSMfRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPP-VPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMER
.. .   .| ..| | .|| |||.|.|...||  . |   . ..|. ||||||| |    ....||.||| |..|| |||..|..|  ..|||.|| .| 
slyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveekvstivmltklveg

NREKCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK--GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfeepgQTSGPIVV
...||..||| .. ... .||..|.|  ||   .|| |......  .|. .|.| ||.  .|||||||| .. .| .|..|... |      .   |..|
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.....dkgvpllV

HCSAGIGRTGTYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIR
|||||.||||..|  || .  ..    . ..|. . ...||. | .|||| .||  .....  .|.  
hCsagvgRtGvfiavdialerlkk...EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 248-508 6.6e-27 88.9 In-house 35-289 (310) alignment 
Range on Protein: 248-508
Range on HMM: 35-289/310.0
KIDSMFRKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERN
|.|.    |       ..  |||. ..|  |.. | |       | || | ||  .     . .| .|| || |. ||| ||.|| .  |... | .|  
kldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeeg

REKCYRYWPSTIDDEmIYGEVNVKLVAEKGQFQYILRQ---FR--VCKGDE-----TERSVHQYHYKSWPDHGVPQDPglflgfIEDVNRKIKDfeepGQ
| ||  ||||    |  || . |  ..|  .   |      |       ||      |  |   ..  ||| |||..          | ...        
rpkcvgywpslgvte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrlla....qv

TSGPIVVHCSAGIGRTGTYIitDILVKlIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYY
  || |||||||..|... .   . .| |.      ..|... .  |.  |   .||. || .. ..   .
rhgpcvvhcsagkdrlyvvv..alklk.idkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 252-513 2.4e-59 195.5 In-house 29-281 (287) alignment 
Range on Protein: 252-513
Range on HMM: 29-281/287.0
MFRKSRKIGVkpenKPKNRFKNIVPYDDTLVTLLDPPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKC
.|... ..        |||. ...|.||| | |   .     |||| ||..     .. .||||| . .||.||| ......| .....|.|.|  | ||
tfkaaeelaa....vkknryadvlPiddtrvllsaegelGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

YRYWPSTiDDEMIYGEVNVKLV-AEKGQFQYILRQFRVCKGDETE-RSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkDFEEPGQTSGPIVVHCSAG
|.|||   .  |  |   | |.  .. . .|  | .|. . .  | | |.|... ||||....     .. |. ||...| . .  ..  ||.|||...|
ykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhi.elardasevGPlvvhddvG

IGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
|||.|... | .||.  |  |   ..|. . . ||||.| ..||.  |....|. .  | .   
iGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyyktnp
0049772 (Phosphotyrosine protein) phosphatases II 253-516 7.7e-47 155.9 In-house 34-287 (314) alignment 
Range on Protein: 253-516
Range on HMM: 34-287/314.0
FRKSRKIGVKPENKPKNRFKNIVPYDdTLVTLLDPPVPDETYINASYVSGEvpgseNCYIAAQGCLQSTVGDF----------WHMI--WQENSRVIVM-
 ....... ...|. |||...|.|.| ..| |   || .  |||||||.|      . .||.|| |. || ||          |.|.  .. |.|.||| 
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------ITKEMERNrekcyrywpstiddemiygevNVKLVAEKGQFQyilrqFRVCKGDETERSVHQYHYKSWPDHGVPqDPGLFL
                    ... ....                     |   .|.  ...      ... ..  || . .|..  .||...| ..  |.
rdevladelsrLdaAlgKtpllildgng.....................neptaadlellk.....eelydpelferlgikylripvpDgsap.lledfd

GFIEDVNRKikdfeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIeyqGwdaeIDIQQSIRRLREFRS-----GMVQTDQQYKMVYQIISYYIQIREK
 |.| ...         .. ||..|||.||.|||||......|.||    |    ..... ....|. |.     |.... .|| ...... .|..  .|
eflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmkll...g....vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk

LL
  
fy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 254-513 2.3e-64 212.0 In-house 9-268 (270) alignment 
Range on Protein: 254-513
Range on HMM: 9-268/270.0
RKSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGEvPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCY
 .. ..     .|  ||...|.|   | |.| .    .  .|||| || |   |... ||||.| |..|. .|| |||.|... |||.|. .|..|.|| 
tsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGf.dgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

RYWPSTIDD--EMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETERSVHqYHYKSWPDHGVPQDPG--LFLGFIEDVNRKIKDFEEPGQTSGPIVVHCSA
||||.  ..  .. .|...|  ..|. .  |||.. |. .  |..| || ..|..|||||||....  |    .  . |... .|.  . ..|..|||||
rYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
|.||||| |..|| |.|.| ..   ..|. . |..||. |  .||. .||...|. .. |.. |.
GvgRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
0045098 (Phosphotyrosine protein) phosphatases II 255-511 1.4e-76 252.8 In-house 23-274 (278) alignment 
Range on Protein: 255-511
Range on HMM: 23-274/278.0
KSRKIGVKPENKPKNRFKNIVPYDDTLVTlldppvpDetYINASYVSGEvpGseNCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRY
 .   .....|..|||.|.|.||| . |        |  ||||||..|   .  . .||.||.|.||| |||.|.|.....||||.|...|..||||..|
seitpalylgnldknRykdilpydhsrVk.......d..YINAsyidgy..p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-----GDETERSVHQYHYKSWPDHGVPQDP--GLFLGFIEDVNRKIKDFEEPG-------QTSG
||.  .. ..||.. |.|. |.    |.|| ..|.       | ..| |...||..||||||| .|    || ..| ... .| . .         . .|
wpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGIGRTGTYIITDILVKLIeyqgwDAEIDIQQSIRRLREFRSG-MVQTDQQYKMVYQIISYYIQI
|..||||||.|||||... ... .|.     .  .|... .. ||. | | .||. .||. .|. . .... 
pvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRN_pd Subfamily PTPRN 255-506 1.4e-54 179.8 In-house 46-289 (297) alignment 
Range on Protein: 255-506
Range on HMM: 46-289/297.0
KSRKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVP-DETYINASYVSGEVPGsENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYR
...... ...|  ||| |...|||.. |.| .     .. ||||| .  . |  . .|||.|| | ||| ||| |.|.. . |||..|.  | . ..|.|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpr.apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPSTidDEMIYGEVNVKLVAEKGQF-QYILRQFRVCKGDE-TERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdfeepGqTSGPIVVHCSAGIG
||| .   . .|.  .|.||.|.    .|..| | .   .    |.| |.|. |||..|||  .  .| |   ||.  .     |  | |||||||.| |
ywpde..GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr.....G.rscpivvhcsdGaG

RTGTYIITDILVKLIEyQGWdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIIS
|||.||. |.... .  .|   ||||  ..  ||. |.|.|.| .|...... ..
rtGvyilidlvlnrll.kGv.keidiaatlehlrdqrpglvktkdqfefaltava
subfamily_eak_pd Subfamily eak 255-516 4.6e-27 89.3 In-house 42-312 (332) alignment 
Range on Protein: 255-516
Range on HMM: 42-312/332.0
KSRKIGVKPENKPKNrFKNIVPYDDTLVTLLDPPVPDETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRY
.| . . . |.  .|   .|||||  || |       . ||||| .  | .   . || .    .. |  || |. ...|  ||.. ...| . ||  .|
lsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPSTIDDEMIYGEVNVK--LVAEKGQFQYilRQFRVCKGDETERsVHQYHYKSWPDHGVPQDPG--LFLGFIEDV-------------NRKIKDFEEPGQ
.|    .|. .| ..|.     .......  |.. . ||.|| | |. |..  | .  .|.      .   . .|             .  .| .     
fpdktreelkfGildverkefvkrnilet..rllelskGnethr.vlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtpp

TSGPIvVHCSAGIGRTGTYIITDILVKLIEYQGwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLL
.  || . .. |  |.|.... |.|..||. .       ... | . .. |   | ...|. ..|.|.  |.. |.. |
sfapi.iqsarGsaraGvfvvidllirlidnkk.knlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 256-505 3.2e-57 188.9 In-house 40-275 (315) alignment 
Range on Protein: 256-505
Range on HMM: 40-275/315.0
SRKIGVKPENKPKNRFKNIVPYDDTLVTL-LDPPVPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRY
  ..  | ||| |||. ||..|| . | | |    |.  |.||... |     .. |||||| . ..|.||| ....|.   |||.|. .|....|. .|
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky

WPstiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETeRSVHQYHYKSWPDHGVPQDPGLFLGFIedvnRKIKDFEEPGQtsGPIVVHCSAGIGRTG
||   |...|||.. | .. |. . .|  | . |  ||.  | | |.|| |||| |||.    .. .|    |..| ...     |.||||||||.||||
wp...dkkviyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgvpkytiplmnli....rtvkqhhtnsv..gaivvhcsaGvGrtG

TYIITDILVKLIEyqgWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
|.|  | ... .|    .  ||. . |...|. | .|||. .||...|...
tfitldavldqae...aenaidvynfitgvrqnrikmvqvaeqyqfiydal
0040439 (Phosphotyrosine protein) phosphatases II 257-509 9.2e-77 253.3 In-house 3-246 (249) alignment 
Range on Protein: 257-509
Range on HMM: 3-246/249.0
RKIGVKPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYW
.... .||||.|||...|.||| . | | . | ...  ||||||.  ... . . .||.||.|..||.|||.|.|.....||||.|...|..||||..||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PStiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFeepgQTSGPIVVHCSAGIGRTG
|.  .... ||.. |.|. ..    |..|.... . .| ..| |....| .|||||||...  .| ||| |.  ...      ..||..||||||.||||
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtG

TYIITDILVKLIEYQGWdaeIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
|.|. .... ..|. .    .|... .. ||. |.|.||...||. .|... ...
tfiaaylmleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 257-506 6.3e-42 138.2 In-house 48-280 (290) alignment 
Range on Protein: 257-506
Range on HMM: 48-280/290.0
RKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPvpDETYINASYVSGevpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWP
|||  |  .  |||.|..|  | | | | |    |  |. | || |     .  .| .|| |..|| |.| |. ||.  .|||. . .|  . || .|.|
rkifdkntefkknrykdvvcndktrvilkdGy..dGdyvhanyvkG....lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp

STIDDEMIYGEVNVKLVAEKGQFQY-ILRQFRVCKGDE-TERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVnRkikdfeepgQTSGPIVVHCSAGIGRTG
 .  . . .||. |    |. . .  |.. . | . |.  |  .. .. |||||. |..    .|  .  . |         ..|||.||||||||||||
ekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.r.........kasGpvvvhcsaGiGrtG

TYIITDILVKLIEyQGwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIIS
|..  .. ....  .|   |.|. . .| ||. | . || | || .. .|. 
tfvaievglqill.dG..keldlldlvralrnsrlnsvqvdiqylalveill
subfamily_ptpA1_pd Subfamily ptpA1 257-468 7.5e-39 128.6 In-house 39-258 (418) alignment 
Range on Protein: 257-468
Range on HMM: 39-258/418.0
RKIGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGEVPgseNCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYW
   | |  |  |||. ||.| . | | |          |||| |. |  |   . .|..|| |  |. |||.|.|..  |.|||...| |  | || |||
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PSTIDDEM--IYGEVN-------VKLV--AEKGQFQYILRQFRVCKGDETeRSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFEEPGQTSGPIVV
|  |  |   |||. |       |.||   .  . . | |. |.    || | . ||.|. |||| .|.    |  ..  .  . ..     .   ||.|
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGIGRTGTYIITDILVKLIEY
|||||.|||||.  . |..| ...
hcsagvgrtgtfctavimmkkldh
0037934 (Phosphotyrosine protein) phosphatases II 258-509 1.9e-73 242.3 In-house 3-242 (243) alignment 
Range on Protein: 258-509
Range on HMM: 3-242/243.0
KIGVKPENKPKNRFKNIVPYDDTLVTLldppvPDETYINASYVSGEvpgseNCYIAAQGCLQSTVGD----FWHMIWQENSRVIVMITKEMERNREKCYR
.|. .|||..|||...|.|||.. | |     ... ||||... .      . .|| || |..|| |    ||.|.|.....||||.|...|..||||..
siallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPstidDEMIYGEVNVKLVAEKGQFQYILRQFRVCK--GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKD-----FEEPGqtsGPIVVHC
|||    .|. ||.. |.|. |.   .|..| ....    |. .| |..||| .|||||||..|  .| |...|.  |..      . .|   ||..|||
ywp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg...gpvlVHC

SAGIGRTGTYIITDILVKLIeyqgwdaEIDIQQSIRRLREFRSG-MVQTDQQYKMVYQIISYYI
|||.|||||.|. ... .|.       ..|... ...||| |.| .||| .||. .|... ...
saGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_CG7180_pd Subfamily CG7180 258-509 6e-45 148.1 In-house 35-290 (296) alignment 
Range on Protein: 258-509
Range on HMM: 35-290/296.0
KIGVKPENKPKNRFKNIVPYDDTLVTLLDPP-VPDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNReKCYRYWP
. |.. ||. |||  ..|||| . | |       .. ||||.|| . .   .. ||  ..  ..||..|| ....|..  .|..||... .. ..  |||
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

STIddEMIYGEVNVKLVAEKGQFQYILRQFRVCKG-----------DETERSVHQYHYKSWPD-HGVPQDPGLFLGFIEDVNRKIKDFEEpGQTSGPIVV
 .   .  |||. |..| ||   .   |.|.. |            .  .| |...... |.  . ||     .. ... |.  ..  .|  .. ||.||
nks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvde.dpeegPvvv

HCSAGIGRTGTYIITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
..| | .|.| |.  |. . |.| ..   |.|. . ...||. | ..|.. ..|| .|.... ..
vssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 258-410 2.9e-10 34.2 In-house 89-234 (244) alignment 
Range on Protein: 258-410
Range on HMM: 89-234/244.0
KIGVKPENKPKNRFKNIVPYDDTLVTLLDPPVpDETYINASYVSgeVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKeMERNREkcyrYWPS
|  ..|.|  |||    .|.|   | |    .  .||||||.|     |    || .|  |  |  |||.|. .    |.|..   .| . |    ||| 
kdafnpnnswknregaglpfdfnrvplskgsm.gntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veeede....ywpd

TIDDEMIYGEVNVKLvAEKGQFQYILRQFRVCKGD--ETERSVHQYHYKSWPDHG
.   |    .. | | ... .|. |       . |  |. ...  .    ||  |
seplewyeeditvtl.tdrdefknikasnleiesdmneshqaltmfqisnwpsdg
0042113 (Phosphotyrosine protein) phosphatases II 259-509 2.7e-77 254.7 In-house 3-243 (245) alignment 
Range on Protein: 259-509
Range on HMM: 3-243/245.0
IGVKPENKPKNRFKNIVPYDDTLVTLLDPPVP-DETYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPS
.. .||||.|||...|.|||.|.| | ...   | .|||||||   ..   . .||.|| |..||.|||.|.|......|||.|.|.|..|.||..|||.
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

tiDDEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfeepgQTSGPIVVHCSAGIGRTGTY
  .... ||.. |.|. |.    |..|...| . ||  .| |..||| .||||||| .. |.| |.| |.. ...       .||..||||||.|||||.
..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtf

IITDILVKLIEYQGwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
|. .... ..|. .   ...... ...||..|.|.|||..||. .|... ...
iaaylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN1_pd Subfamily PTPN1 259-505 3.8e-65 214.5 In-house 26-267 (290) alignment 
Range on Protein: 259-505
Range on HMM: 26-267/290.0
IGVKPENKPKNRFKNIVPYDDTLVTLLDPPVpdeTYINASYVsgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPST
   .|||...||.... ||| . ..| .  .    ||||| |  |..  .  || .|| | .||. ||.|.|...|. .||. | .|... ||..|||. 
eaklpenrnlnryrdvspydhsrikleradn...dyinaslv..eleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

ID-DEMIYG--EVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKikdfEEPGQTSGPIVVHCSAGIGRTG
 . .|...   ...|||..|. . .|..|.... .   .  |.. ..|| .||| |||. |. || |. .| .         .  || |.||||||||.|
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres....GslssdvGpavihcsaGiGrsG

TYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
|... | .. ||| ..  . .||.. .  ||..| |..|| .| .. |. |
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 259-511 5.3e-63 207.6 In-house 3-244 (250) alignment 
Range on Protein: 259-511
Range on HMM: 3-244/250.0
IGVKPENKPKNRFKNIVPYDDTLVTLLDPPV-PDETYINASYVSGEVpGSeNCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREkCYRYWPs
.. ||.|| |||. .|...| . | |       .  |||||.. |   .. . .||.|| ||.|. ||| |...|.| .|||.|.  | ... . .||| 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.

tIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETER-SVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKikdfeEPGQTSGPIVVHCSAGIGRTGTY
 ..   .||.| |.|  ..    |. |.. . |  ....  | |.|. .||| |||.     |.....|...     ..   ..|..|.||||.||.|..
.vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqas.....qqqagnaPvivqCsaGvgrsGaf

IITDILvklIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQI
|. | .   .|    .  .|. . |..||. | ..|.. .|| .||.||  ... 
iaidav...lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 259-510 5.9e-34 112.5 In-house 35-279 (307) alignment 
Range on Protein: 259-510
Range on HMM: 35-279/307.0
IGVKPENKPKNRFKNIVPYDDTLVTLLDPPVpDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPST
.     |  |||....   | . . .  . .    || | |.   .    . .|.||| |..|. .|| |. ||.   ..|. | .|  . || .|||  
veafsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

IDDEMIYGEVNV---------KLVAEKGQFQYiLRQFRVCKGDETeRSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNrkikdfeepgQTSGPIVVHCSAG
  .....|| .          | .|   ..   . ...|  .... |..... .. |||.||||     . ..| |.              |.|||||||
egqklvfgeapntisvanlgakklapdedlin.vttlkvdwaqks.rtiqhlqwenwpdrgvpqinltainlleavr..........ydtnpvvvhcsaG

IGRTGTYI-ITDILVKLIeyQGWDAeIDIQQSIRRLREFRSGMVQTDQQYKMVYQII-SYYIQ
.||.|| . |. .  |.|  .| .   |... .. ||. |   .||. ||  ..... .|...
vGrsGtivaislvqdkmi..aGinc.kdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 262-517 6.9e-62 204.2 In-house 40-284 (515) alignment 
Range on Protein: 262-517
Range on HMM: 40-284/515.0
KPENKPKNRFKNIVPYDDTLVTL-LDPPVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTID
.  | .|||.|||.||| . | | .    |.. |.||||. .    ....|||.|| ....| |||....|||   |.|.||  | .. || .|||    
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsf..dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

DEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDEtERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRkikdfeEPGQTSGPIVVHCSAGIGRTGTYIITD
| . .|...|.||. .   . | |...| |||.  | | |.|.. |||.|||..   .| .| .|        . || . |...|||||.|||| .|  |
dsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevka......dhgqythpliihcsaGvGrtGvvisid

ILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIREKLLS
  |  ..       .|. . .. .|. |  .|||..|| ..|...  ..  |. |. 
svvahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlip
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 262-513 4.6e-56 185.1 In-house 45-288 (297) alignment 
Range on Protein: 262-513
Range on HMM: 45-288/297.0
KPENK---PKNRFKNIVPYDDTLVTLLDP-PVPDETYINASYVsgevPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNReKCYRYWPS
. |.|   .|.|.|||.|||   |.|      ||  |.|||.|    .| .. .|. |   ..|| ||| |...|.  .|||.... ||.. || |||. 
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv....kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

TIDDEmiYGEVNVKLVAEKGQFQYILRQFRVCKGD-ETERSVHQYHYKSWPDHGVPQ--DPGLFLGFIEDVNrkiKDFEepGQTSGPIVVHCSAGIGRTG
.   .  .|.| |.| . . .  .| |.. | ||.  ..| |.||.. .|||. |..  .   .| .|..|.   |||.  ....||..|||.||.||||
kgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr...kdfs..qnaegPllvhclaGvGrtg

TYIITDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIRE
 ..  |  |  ..    . |.|| . ...||. |  .|||..|||.||...  ..   .
vlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 262-502 7e-53 174.2 In-house 5-234 (239) alignment 
Range on Protein: 262-502
Range on HMM: 5-234/239.0
KPENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPstiD
|  || |||. ||| || . | |      |   ||||||.  .  || ..|||.|||.. . ||||.|.|||   ||||.|  .|  ..||..|||   |
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...d

DEMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGfiedVNRKIKDFEEPGqtSGPIVVHCSAGIGRTGTYIIT
    | .. | |   .   .||.| | . . |.  || |.|||.  |||.||||     ||    . |||     ||  . | |.|||||.||||.... 
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg....lrrkitkdslpg..arpwvihcsagvgrtgaflvi

DILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVY
| ...  . |     .|| . .. .|| |  |||| .|| ...
damlrqakkq...ktvdifnyvkairedrphmvqtseqyvfih
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 262-505 2.1e-45 149.9 In-house 30-291 (297) alignment 
Range on Protein: 262-505
Range on HMM: 30-291/297.0
KPENKPKNRFKNIVPYDDTLVTLLDPpVPDETYINASYVSGEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDD
..    |||...|. .||| | ||   .... |||| ||      ..  || ||| |..|| |||....... |||||..|  |  |.||. ||||. ..
rnsslrknryrdilatddtrvkllrv.iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

EMIYGEVNVKLVAEKG-QFQ-YILRQFRVCKGdETERSVHQYHYKSWPDHGVP---QDPGLF--------------LGFIE----DVNRKIKDFEEPGQT
 .  |.| |. ...   .|.  || ....    . .| |.   . ||||||||   .|   |              |. .|     |  ... ..     
rlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

SGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
. ...||||||.||.|  . .|.... .  .      |..  .. ||| |. .||| .|....|...
nayllvhcsaGvGrsGvvvlsdvilaklrkk...ripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 262-506 3.5e-34 112.7 In-house 34-266 (281) alignment 
Range on Protein: 262-506
Range on HMM: 34-266/281.0
KPENKPKNRFKNIVPYDDTLVTLLD--PPVPDETYINASYVSGevPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTI
.| |. |||. ||   | . | |    |      || | |.    |  .  || .||  . |  |||.||||||.  |||. . .| |||||  |.|   
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

DDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETeRSVHQYHYKSWPDHGVPQDPGLFLgfieDVNRKIKdfeepgQTSGPIVVHCSAGIGRTGTYIIT
   . . .. |.      .   .  .. .    || | . .. .| |||  ||.   ..|     . |||.        | | |.|||||.||.|| .  
hcclqfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqvpessevml....kilrkir......arstppvihcsagvgrsgtlmav

DILVKLIEYQgwDAEIDIQQSIRRLRE-FRSGMVQTDQQYKMVYQIIS
.| .. |  .   .  ||.| . .||   |.  ||| ||| ...... 
eialqsihsh..ftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 262-510 6e-18 59.3 In-house 48-286 (302) alignment 
Range on Protein: 262-510
Range on HMM: 48-286/302.0
KPENKPKNRFKNIVPYDDTLVTLLDPPvpdETYINASYVsgEVPGSENCYIAAQGCLQST---VGDFWHMIWQENSRVIVMITKEMERNReKCYRYWPST
  .|  ||. ...  .|..|| |   |   . |.||| |  |||  ..  | ||   ...   | .||.|..||.   .|.. .| | ..     ..| .
fkknlkknqsedvpildsnlvkleaep...dsyvnaskv..evPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

IDDEMIYGE--VNVKLVAEKGQFQ--YILRqfRVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVnrkikdFEEPGQTSGPIVVHCSAGIGRTG
 .|   ||.  ||.. | .. . .  |..    . .|      .  |. . |... ||.  .     ...|      |..  ... ..|.    |.|| |
sgdykeygkmfvNnrkVekaeeektryviE..vlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv......fakkikadentvivSknGaGRag

TYIITDILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
. .   . |. .. .   .|  |.. .. .|. |. .|.. .|| ..| .. .||.
afltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 263-510 1.7e-69 229.0 In-house 26-269 (274) alignment 
Range on Protein: 263-510
Range on HMM: 26-269/274.0
PENKPKNRFKNIVPYDDTLVTLLDPPVPDE--TYINASYVSGEvPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTID
. .. |||.|.|.| . . |.|    . ||  .|||| |. |   . ...|.|.|| |..|| |||.||.||...||||.||  |.|..|| .|.| ..|
fgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

DEM--IYGEVNVKLVAEKGQFQYILRQFRVCKGDEtERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdfeEPGQTSGPIVVHCSAGIGRTGTYII
 |.   ||.|..| .  . . .| .|.. . .  . ||||. | | .|||| .|.|.  .| ....|... .   |  .  .|.|||||||||||| .| 
yeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesre...eenaklapvvvhCsaGiGrtGcfia

TDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
..| |. ..    .  .|. . .  ||  | |||||..||........ | .
isiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 263-505 5.4e-60 198.3 In-house 23-251 (284) alignment 
Range on Protein: 263-505
Range on HMM: 23-251/284.0
PENKPKNRFKNIVPYDDTLVTLlDPPVPDE--TYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITkemernREKCYRYWPSTID
..|| |||. .|...| . | | .. .  |   |||||...|    ... |||.|| |. |. ||| |||. |.  ||..|      ..|| .|||  |.
dqnkdknrighilafdknvvkl.erliGeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

DEMIYGEVNVKLVAEKGQfqYILRQFRVCK-GDET-ERSVHQYHYKSWPDHGVPQDPGLFLGFIEdvnrKIKDFEEPGQTSGPIVVHCSAGIGRTGTYII
 .   ..|.|..| |  .  |..|.... . | |.  |...|.|.. |||.|||. |  .. ...    |.. ...  .   .||||||||.||||.||.
ikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvk....kvrhltskenhranivvhcsagvgrtgvyiv

TDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
 |.|.. ..    .  .|. . .| ||. |. .||   |||..|  .
ldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 263-502 7.5e-53 174.1 In-house 5-233 (239) alignment 
Range on Protein: 263-502
Range on HMM: 5-233/239.0
PENKPKNRFKNIVPYDDTLVTLLD-PPVPDETYINASYVSgEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPstiDD
  || |||. ||| || . | |      |   ||||||.  .  || ..|||.|||.. . ||||.|.|||   ||||.|  .|  ..||..|||   | 
rvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...ds

EMIYGEVNVKLVAEKGQFQYILRQFRVCK-GDETERSVHQYHYKSWPDHGVPQDPGLFLGfiedVNRKIKDFEEPGqtSGPIVVHCSAGIGRTGTYIITD
   | .. | |   .   .||.| | . . |.  || |.|||.  |||.||||     ||    . |||     ||  . | |.|||||.||||.... |
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg....lrrkitkdslpg..arpwvihcsagvgrtgaflvid

ILVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVY
 ...  . |     .|| . .. .|| |  |||| .|| ...
amlrqakkq...ktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 264-505 6.2e-55 181.0 In-house 2-235 (237) alignment 
Range on Protein: 264-505
Range on HMM: 2-235/237.0
ENKPKNRFKNIVPYDDTLVTLLDpPVPDETYINASYVSGeVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTiDDEM
||| |||. ||| || . | |   .  .  ||||.|. | . |. . |||||| |.|.  ||| |.|||.  ||||.|  .|.|..||..||||| |.  
enkiknrygnivaydhsrvvlkg.agsgsdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpa

IYGEVNVKLVAEKGQFQYILRQFRVCKGDE--TERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKikdfEEPGQTSGPIVVHCSAGIGRTGTYIITDI
 || . | |  ..   .| .| . . |  .    | .|||.. ||||.||||    .| |  ..  .     .  . ||| ..|||||.|||| ... | 
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinr....sphvsesgpwiihcsagvgrtgiflvida

LVKLIEYQgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
...  . .     .|| . .  . | |  ..|| .|| ...| |
mlrqakek...kvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 264-512 1.1e-31 105.0 In-house 42-274 (288) alignment 
Range on Protein: 264-512
Range on HMM: 42-274/288.0
ENKPKNRFKNIVPYDDTLVTLLDPPvpdETYINASYVSgeVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEM
.|  ..|..|.   | | | | | |   . ||.|  ||      ..  | ||  |..|.. .|.|. ... . |||... .|. .||   |.|| . ...
anptrdryenlprcditrvklsddp...dfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

IYGEVNVKLVAEKGQFQYILR--QFRVCKGDETERSVHQYHYKSWPDHGVPQDpglFLGFIEDVNRKikdfeepGQTSGPIVVHCSAGIGRTGTYIITDI
 .| .      .. . . ...   .|. |  |..  | . |.. |.|.|||..   .| ..  ...         ..  |||||.|||.||||| |.. |
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen...ylsplrllevl.......kslqkPivvhssaGvGrtgtlilili

LVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQIR
 .. .     |  . |.. . .||| |   .|| .||  |.... ... ..
aleslrl...ddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 264-509 6.3e-17 56.1 In-house 46-279 (303) alignment 
Range on Protein: 264-509
Range on HMM: 46-279/303.0
ENKPKNRFKNIVPYDDTLVTLLdppvpDETYINASYVSGEvpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIdDEM
.|  |||| ...  | . | |      | .|| |||.  .   |..  | .|  |. |  ||| || ... ......  . | ..      .|    | .
knmdknrfvdvicldhskvkls.....dssyihasyleld...sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq.dfl

IYGEVNVKlVAEKGQF----QYILRQFRVCKGDEtERSVHQYHYKSWPDHGVPQD-PGLFLGFIEDVNRKIKDFEEpgqtSGPIVVHCSAGIGRTGTYII
 . |  .. | |  .      . |.   | .||     .| .|||.||   .| |    |.  | ...  .. . .    | | |    .| ||.||. .
kfeersir.vgefkrvelgdgwvlkvlsvsngdy.ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd....stptvymslsgcgragtfal

TDILvkLIEYQGWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
 .     .  .  .| .|. . .  .|. |   ||   |. .|| ... ..
feta..hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
Y_phosphatase Protein-tyrosine phosphatase 265-505 2.7e-77 254.7 Pfam-A 1-233 (235) alignment 
Range on Protein: 265-505
Range on HMM: 1-233/235.0
NKPKNRFKNIVPYDDTLVTLLDPPVPDEtYINASYVSGEVpGsENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMI
|| |||.|.|.|||.| | | . . | . ||||.||.|     .. .||.||.|.||..|||.|.|||...||||.|...|..|||| .|||.. .... 
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEVNVKLV-AEK-GQFQYILRQFRVCKGDETE--RSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkdfeepGQTSGPIVVHCSAGIGRTGTYIITD
||...|.|.  ||  . .|.||.... | .| .  |.|.|.||..|||||||..|  .| .|..|...        ..|||.|||||||.|||||..  |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvald

ILVKLIEYQGWdaeIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
||.. .| ..    .|. | ...||. | ||||. .||...|..|
illeqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 265-505 2.7e-77 254.7 In-house 1-233 (235) alignment 
Range on Protein: 265-505
Range on HMM: 1-233/235.0
NKPKNRFKNIVPYDDTLVTLLDPPVPDEtYINASYVSGEVpGsENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMI
|| |||.|.|.|||.| | | . . | . ||||.||.|     .. .||.||.|.||..|||.|.|||...||||.|...|..|||| .|||.. .... 
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEVNVKLV-AEK-GQFQYILRQFRVCKGDETE--RSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkdfeepGQTSGPIVVHCSAGIGRTGTYIITD
||...|.|.  ||  . .|.||.... | .| .  |.|.|.||..|||||||..|  .| .|..|...        ..|||.|||||||.|||||..  |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvald

ILVKLIEYQGWdaeIDIQQSIRRLREFRSGMVQTDQQYKMVYQII
||.. .| ..    .|. | ...||. | ||||. .||...|..|
illeqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
0041856 (Phosphotyrosine protein) phosphatases II 265-511 3.6e-51 168.7 In-house 1-173 (182) alignment 
Range on Protein: 265-511
Range on HMM: 1-173/182.0
NKPKNRFKNIVPYDDTLvtlldppvpDETYINASYVSGEVPGSEncYIAAQGCLQSTVGDFWHMIWQENSRVIVMITkemernrekCYRYWPstiddemi
|..|||...|.||| ..         | .||||... |  |...  .||.|| |.||| ||..|..... ..||..|         ...|||        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

ygevnvklvaekgqfqyilrqfrvckgDETERSVHQYHYKSWPDHGVPQdPGLFLGFIEDVNRkikdfeepgqTSGPIVVHCSAGIGRTGTYIITDILVK
                           .. || ..||.| .|||||||  .  .| |||.|..           .||..||||||.|||||... ... |
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmkk

LieyqgwdaEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQI
|        ...... .. .|. |.|||.| .|| ...... .... 
l........gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 265-510 1.4e-33 110.8 In-house 55-290 (305) alignment 
Range on Protein: 265-510
Range on HMM: 55-290/305.0
NKPKNRFKNiVPYDDTLVTLLDPPVPDeTYINASYVSGEVPgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDE-M
.. |||... || .|  . .|| | |   || | ||   .   |. .|.||| |. |. .|| |. |..   |||. | .|  . || .||| .  .   
aitknryqd.vpcqdqsavkldkpsps.dyihanyvgcpmi.pekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

IYGEVNVKLVAEKGQF----QYILRQFRVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVnrkiKdfeepGqTSGPIVVHCSAGIGRTGTYI-I
. . . |. |.    .    .  .  ....   . . || . ..  ||| |||      | ..  .    .     | .  ||||||||||||||| . |
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai....r.....g.skvpivvhcsagigrtgtivai

TDILVKLIEYQGWDAEIDIqqsIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
  || |. | .      ..   .. ||. |.  .|.| || ......  |. 
eyilekiaenkpcppmpel...vkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 265-509 4.9e-27 89.6 In-house 35-270 (285) alignment 
Range on Protein: 265-509
Range on HMM: 35-270/285.0
NKPKNRFKNIVPYDDTLVTLLDppvPDETYINASYVsgEVPGSE-NCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEM
|   ||. ..   ..| | | .    |  || ||..   .|| . . ||..|| |  |. ||||||.||.   ..|.   .|   |||  |.|  . . .
npdlnryadvrcieetrvvlkn...hdrdyihaswm..rmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

IYGEVNVKLVA--EKGQFQYILRQFRVCKG-DETERSVHQYHYK--SWPDHGVPQDPGLFLGFIEDVnRKIKdfeePGQTsgPIVVHCSAGIGRTGTYII
 .|. .. |    |.     ||  . | .  | .   ..  | .   |||.  |.|   .. . . | .|..    | ..  ||.||||||.||| |.. 
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwv.kkvn....pkek..picvhcsagvgrtatfvg

TDIL-VKLIEyqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
 |   ....|    . .|.. . .| .| .|   ||.  |. ..| ..  |.
idyatirime....npniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 266-517 2.9e-33 109.9 In-house 51-288 (301) alignment 
Range on Protein: 266-517
Range on HMM: 51-288/301.0
KPKNRFKNIVPYDDTLVTLLDPPvpDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMIY
| |.|....    .| | ...        | | ... .  |  . .||.|| |..|  ||| |. | .   |||.....|.. |||  | |..| ...  
kdkhryptvPckPstavevivdG..krvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GEVNVKLVAEKGQFQ--YILRQFRVC--KGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVnrkiKDFEEpgqtsgPIVVHCSAGIGRTGTYIITDI
|  ..|.. ..  ..   . |...|    |. . |.|  | |..|.|.|||.       ..| |    |. |.      ||||||||||||. ..| |..
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelv....kksek......PivvhcsaGiGrsvafigtey

LVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVyQIISYYIQIREKLLS
| . .|    | .|........||| |   ||| .|   . .. . |  |.|. . 
larevea...dptieltealkhlrehrwngvqtnsqlywm.tlGtvyrlikeygfd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 266-359 3.6e-23 76.9 In-house 48-154 (350) alignment 
Range on Protein: 266-359
Range on HMM: 48-154/350.0
KPKNRFKNIVPYDDTLVTLLDPP---------VPDETYINASYVSGEVPGSEN----CYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCY
  |||.|||.||. . | |   .         .  . ||||.|.. .... |      |||.|. |.||| ||...| . . .||...|...| |.||||
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPSTI
|||.   
rYWqegs
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 266-508 9.5e-21 68.8 In-house 44-275 (312) alignment 
Range on Protein: 266-508
Range on HMM: 44-275/312.0
KPKNRFKNIVPYDDTLVTLLDppvPDETYINASYVSgeVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPST-----ID
|  ||. ||  .|    ||      .. || | .|   .    . ....|| |..|.  ||..     |  |....  .|   ||| .|         ..
kdlnrypniqcwdrgrftlag...denfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

DEMIYGEVNVKL-VAEKGQFQYILRQFRV-CKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdfeepgqtsgPIVVHCSAGIGRTGTYII
|  .| |   .. .  | . .   | ..|  |    |  . .| . ||||||.|.     | ..  |..  |          |.. |||||.||||| ..
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk..........pviahcsagvgrtgtlal

TDILVKLIEYqgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYY
 . ..  . .       ....|   ||  |.  |..  || .. ...  .
iesmiaalrh...prkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 267-372 4.9e-14 46.4 In-house 50-165 (349) alignment 
Range on Protein: 267-372
Range on HMM: 50-165/349.0
PKNRFKNIVPYDDTLVTLLDPPVPD---------------ETYINASYVSGEVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKC
 |||.|.|.||. . | |   . .                . |||| |..      |. ||| |  | ||| ||...|  .. .... .... | . |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

YRYWpstidDEMIYGEVNVKL
..||     .|. | ...|||
diyw.....qelsysnitvkl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 268-341 3.5e-06 20.8 In-house 40-117 (347) alignment 
Range on Protein: 268-341
Range on HMM: 40-117/347.0
KNRFKNIVPYDDTLVTLL------DPPVPDETYINASYVSGEvpGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMIT
||| |.    |.| | |        .  . |||||||..  .   ... || .|  | .|| |||.|.   .   .| | 
knrskdvklidatrvvlspeksknsraddvetyinashikfd..naskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0044763 (Phosphotyrosine protein) phosphatases II 276-510 1.6e-34 114.5 In-house 1-172 (178) alignment 
Range on Protein: 276-510
Range on HMM: 1-172/178.0
PYDDTLVTLLDPPV-PDETYINASYVSgevpgsENCYIAAQGClqstvGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDdemiygevnvklva
|.|.|.| |  ..  .   |||||..       .. |......      |.. ...... ..||..|.|.|....||..|||.  .              
pldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

ekgqfqyilrqfrvckgdetersvHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkdfeepGQTSGPIVVHCSAGIGRTGTYIITDILVKLieyqgwdaE
                         ||..  .||||||. .  || |.| ... .       .  ||..||||||.||.|| .. ... ||         
........................iqylhipipDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl........g

IDIQQSIRRLREFRSgMVQTDQQYKMVYQIISYYIQ
..... |...|| |. .|... |.. .|.. ... .
lsleeaielvrerRp.ivpnpgqlrqLyefelrllk
0046846 (Phosphotyrosine protein) phosphatases II 286-508 9.2e-44 144.6 In-house 6-172 (176) alignment 
Range on Protein: 286-508
Range on HMM: 6-172/176.0
DPPVPDETYINASYVSGEvpgsenCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMiygevnvklvaekgqfqyilrq
. . .| .||||... |       ..|| || | .|. ||..|..... ...|..|.|.| .| ||..|||   . ..                      
lgldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

frvckgdetersvhQYHYKSWPDHGVPQDpGLFLGFIEDVNRKIKDfeepGqtsGPIVVHCSAGIGRTGTYIITDilvkLIEYqgwDAEIDIQQSIRRLR
              ||..  |||||||..  |.| ..| ... .|.    |   ||..||||||||||||... .    |.|.   .  ..... ....|
..............qylhlpwpDhgvpdl.elllellefirealke....g...gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvr

EFRS-GMVQTDQQYKMVYQIISYY
| |. |.|||..||...|. . ..
eqRplgavqtpeQyrflyefelll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 289-410 2.2e-07 25.3 In-house 10-125 (130) alignment 
Range on Protein: 289-410
Range on HMM: 10-125/130.0
VPDETYINASYVSgeVPGSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKeMERNREkcyrYWPSTIDDEMIYGEVNVKLvAEKGQFQYILRQFRV
....||||||.|   . |  . |. .|  |  |  |||.|. .    |.|..   .| . |    ||| .   |    .. | | ... .|..|  ..  
lqgntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeede....ywpdsePlewyeediivtl.tdrdefknikasnle

CKGDETE--RSVHQYHYKSWPDHG
 . |  |  ...  ..   ||  |
iesdlneshqaltmfqisnwpsdg
0051429 (Phosphotyrosine protein) phosphatases II 290-509 5.5e-50 165.8 In-house 2-225 (272) alignment 
Range on Protein: 290-509
Range on HMM: 2-225/272.0
PDETYINASYVSGEvpGS---ENCYIAAQGCLQSTVGDFWHMiWQENSRVIVMITKEMERNREKCYRYWP----------STIDDEMIYGEVNVKLVAEK
| ..||||..|.|   |.   .. .....|.|. |. |||.. .... ..||....|.||.|.||.||||          .. . .. || . |.|. |.
plsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

GQFQYILRQFRVC---KGDETeRSVHQYHYKSWPDHGVPQDPglFLGFIEDVNRkikdfeepgqtSGPIVVHCSAGIGRTGTYIITDILVkliEYQGWDA
 .  |||| ...    . .|. | |...|| .||||||||..  .| ..| ...           .||..||||||..||||..  ..|.   .  ....
llldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvslet

EID--------IQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
 .|        ... ...||. | |.|||..||...|...  ..
ivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
0043147 (Phosphotyrosine protein) phosphatases II 290-503 7.8e-42 138.3 In-house 3-155 (172) alignment 
Range on Protein: 290-503
Range on HMM: 3-155/172.0
PDETYINASYVSGEVpgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEmernrekcyrywpstiddemiygevnvklvaekgqfqyilrqfrVC
....||||||... .    . .|| ||.|..|. |||.|..... ..||..|..                                            ..
egsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel............................................ly

KGDETERSVHQYHYKSWPDHGVPqDPGLFLGFIEDVNRKI--KDfeepgqtSGPIVVHCSAGIGRTGTYIITDILVklieyQGWdaeiDIQQSIRRLREF
 ..  ||.. ||.| .||||||| .. |.| |.| .....  ..       .||..||||||.||||| .. ...      .|.    .... .. .|| 
dpellerlgiqylylpwpDhgvp.llellleflefidellalsp.......ggpvlVHCsaGvgRtgtlvaaylml.....lgl....sleeavalvrek

RSGMVQTDQQYKMVYQ
|.|.||...||. .|.
Rpgavqnpsqyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 291-504 2.3e-32 107.0 In-house 2-148 (151) alignment 
Range on Protein: 291-504
Range on HMM: 2-148/151.0
DETYINASYVSGEvpgsencYIAAQGCLQstvgDFWHMIWQENSRVIVMITKEMERNreKCYRYWPSTIddemiygevnvklvaekgqfqyilrqfrvck
 ..|||.||| |        ... .| |.    ||. ...... ..||....|.||.  .|..|.|..                                
lsdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................

gdeteRSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRkikdfeepgQTSGPIVVHCSAGIGRTGTYIITDILVklIEyqgwdaeIDIQQSIRRLREFRSG
     . |..... .|||.|.|. .  .| |.| ...         . .||..||||||.||||| .. ...            ..... .. .|..| |
.....ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpg

MVQTDQQYKMVYQI
.||. ||. .... 
vvqpnqqflfqlfa
subfamily_egg_pd Subfamily egg 292-510 2.8e-24 80.4 In-house 68-271 (307) alignment 
Range on Protein: 292-510
Range on HMM: 68-271/307.0
ETYINASYVSGEvPgSENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERnrEKCYRYWPSTIDDEMIY--GEVNVKL--VAEKGQFQYILRQFR
. .| | .|.|. |   | .| ||  |. || ||| |..||. . |||.|   |   |.|  ||| . .| ...  | ....   | .| .  . . ...
ddfihanrvkGk.p.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklk

VCKGDETERSVHQYHYkswpDhgVPQDPGLFLGFieDVNRKIKdfeepgQTSGPIVVHCSAGIGRTGTYIITDIL-VKLIeyQGWDAEIDIQQSIRRLRE
.  ||. || .  . .    |  | .   ..  .   | ||..      . | |.||..  |. ...| .  .|  ..|.  .|      .....  || 
lvGgddeerflehwqg....d..vnnssdvyspl..rvlrklr......nlskpvvvqdilGvskaatlvaieiallsll..rGpitkslvlravvflrl

FRSGMVQTDQQYKMVYQIISYYIQ
 |   |..  .| .||... ....
rrrlsvesvllylfvyrlvlfffr
0036282 (Phosphotyrosine protein) phosphatases II 293-503 5.9e-44 145.2 In-house 3-164 (174) alignment 
Range on Protein: 293-503
Range on HMM: 3-164/174.0
TYINASYVSGEVPGSenCYIAAQGCLQstvgdFWHMIWQENSRVIVMITKEMERNREKCYRYWPStiddemiygevnvklvaekgqfqyilrqfrvcKGD
.|||||.... .  .   .|| ||.|.     ||.|.........|| ..|.|....||..|||.                                . .
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

ETERSVHQYHYKSWPDHGVPQDPGlFLGFIEDVNRKIKDfeepgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEyqgwDAEIDIQQSIRRLREFRSGMV
  ||...||.|  ||||||| ..  .| |.. |.. ...       .||..||||||.||||| .. ... ....       .|. . .|.||  |.|||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmv

QTDQQYKMVYQ
||..||. .|.
qtpsQyrflyy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 308-358 7.7e-06 19.5 In-house 235-282 (440) alignment 
Range on Protein: 308-358
Range on HMM: 235-282/440.0
ENCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKemeRNREKCYRYWPST
 |..||.|  |.||| ||| .. . .   |.|. .    |   |  |||  
knafiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvn
0049260 (Phosphotyrosine protein) phosphatases II 309-503 3.5e-39 129.3 In-house 9-144 (152) alignment 
Range on Protein: 309-503
Range on HMM: 9-144/152.0
NCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWpstiddemiygevnvklvaekgqfqyilrqfrvckgdetersvhQYHYKSWPD
. .||.||..  |. |||.|... . ..|||.|...|....||..|.                                            ||..  |||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD

HGVPQDPGLFLGFIEDVNRKikdfeePGQTSGPIVVHCSAGIGRTGTYIITDILVklieyqgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQ
||||... |.| ... ...         . .||..||||||.|||||... ...            ..... ....|| |.|.|.. .|.. .|.
hgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 309-504 4e-27 89.7 In-house 4-198 (198) alignment 
Range on Protein: 309-504
Range on HMM: 4-198/198.0
NCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEmERNREKCY-RYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVC---KGDETERSVHQYHYK
  |||.|  |. |. ||| |.|.  |  |||.  . ..|.|  |  |||.|      || ..|   .   . .| .  . ..       . | . .| . 
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPQdPGLFLGFIEDVNRKIKDFEEpgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQI
|| ..  |.   ||.||.       | .|.  .   |..|||| | | || ..  || |.  |     . .|. .  .|||. | |.. . |.|...||.
swkekttpn.valfvgfvvasrevskkyeq..ekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 309-504 4.3e-27 89.6 In-house 5-199 (199) alignment 
Range on Protein: 309-504
Range on HMM: 5-199/199.0
NCYIAAQGCLQSTVGDFWHMIWQENSRVIVMITKEmERNREKCY-RYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVC---KGDETERSVHQYHYK
  |||.|  |. |. ||| |.|.  |  |||.  . ..|.|  |  |||.|      || ..|   .   . .| .  . ..       . | . .| . 
rryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPQdPGLFLGFIEDVNRKIKDFEEpgQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQI
|| ..  |.   ||.||.       | .|.  .   |..|||| | | || ..  || |.  |     . .|. .  .|||. | |.. . |.|...||.
swkekttpn.valfvgfvvasrevskkyeq..ekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 313-498 3.2e-21 70.6 In-house 39-210 (255) alignment 
Range on Protein: 313-498
Range on HMM: 39-210/255.0
AaqgclqsTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAekGQFQYILRQFRVCK--G-DETERSVHQYHYKSWPDH
        ||  |...| | .. |.||..   | ..||| .|.|   |. ... .|||         . .||  ..    |     . |. |.|| |...
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPQDPglflgfiedvnRKIKDFEEPGQTSGPIVVHCSAGIGRTGTYIITDILVK-LIE--YQGWDAEIDIQQSIRRLREFRSGMVQTDQQY
  |...           | |.      . | ..|||||.||||. ........ . .|    .   .|.|  . .. ||. |.. ..|  | 
naPela...........reilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql
subfamily_hpo-7_pd Subfamily hpo-7 313-497 1.2e-18 62.0 In-house 42-215 (263) alignment 
Range on Protein: 313-497
Range on HMM: 42-215/263.0
AaqgcLQSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVklVAEKGQFQYILRQFRVCK--G-DETERSVHQYHYKSWPDH
     |  |.  |...| | .. |.||..   | ..||| .|.|   |. ... .|||  .. | | . .|.   . .  |   . . |..| || |...
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

GVPQDPGLFLGfIEDVNRKIKdfeepgqtsgPIVVHCSAGIGRTGTYIITDILVK-LIE--YQGWDAEIDIQQSIRRLREFRSGMVQTDQQ
  |...   |  | .|.|. |          ..|||||.||||.  . ..... . .|    .   .|.|  . .. ||. |.. ..|  |
ndpelareiln.ilkvarnsk..........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 318-515 2.5e-23 77.7 In-house 76-266 (290) alignment 
Range on Protein: 318-515
Range on HMM: 76-266/290.0
LQSTVGDFWHMIWQENSRVIVMITKEMERNRE----KCYRYWPSTIDDEMIYGEVNVKLVAEKGQFQYILRQFRVCKGDETERSVHQYHYKSWPDHGVPQ
 .||. .|| |. ||... .||. . .|....     | .| | ....|. .. ..||      . . . |.  |  .|| |  |  . .|.| .  |..
rnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqe

DPGLFLGFIEDVNRKikdfeepgqtSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMV-YQIISYYIQIR
|. ..|  |. |. .            |..|||  || |  .    ..   .|  .    .. ... .  ||. |  ........  | . |. . |.. 
dtktllsliqkvkas..........ktpvivHcvdGiSrsAalaaiilgyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagivllaievl

EKL
.. 
dqf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 319-504 1.4e-19 64.7 In-house 101-281 (302) alignment 
Range on Protein: 319-504
Range on HMM: 101-281/302.0
QSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMIYGEVNVKLVAE---------KGQFQ-YILRQFRVCKGDETERSVHQYHYKSWPD
.||.  .| .| | |  ..| ... .| . .||  |.   ...|. .|.  || |           | .|. | .      | ......|.  .. .|||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

HGVPQDPGLFLGFIedvnRkikdFEEPGQTSgpIVVHCSAGIGRTGTYIITDILVKLIEYQGWDaeiDIQQSIRRLREFRSGMVQTDQQykMVYQI
|| |...   |  .    .    | |  ...  ..||||||.||||| .     ..|   .      |. . .  .|. | | ||..||  ..| .
hGapkeaytaldil....k....fcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqq..liyll
0048076 (Phosphotyrosine protein) phosphatases II 353-507 1.4e-27 91.5 In-house 1-141 (145) alignment 
Range on Protein: 353-507
Range on HMM: 1-141/145.0
RYWPSTIDDEMIYGEVNVKL---VAEKGQFQYILRQfrVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfeepgqtSGPIVVHCSAG
.|||| |.. . .| . . |     .. .. ..|.    .  .  || . ||.| .|||||||... |.| |.| ... .|.        ||..||||||
pywpseilpglylgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaG

IGRTGTYIITDILVKlieyqgwdAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISY
.|||||... ... .          ..... ....|. |.|.|....|....|. . .
vgRtgtlvaaylmll........lgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 354-503 9.1e-26 85.7 In-house 2-139 (144) alignment 
Range on Protein: 354-503
Range on HMM: 2-139/144.0
YWPSTIDDEMIYGEVNV----KLVaEKGQFQYILRQFRVCKGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKdfeepgqTSGPIVVHCSAG
..|| |.. . .| . .    .|   | .. ....    .  .. || ..||.. .|||||||... |.| |.| ... ..        .||..||||||
snpseilpglylgslptaldlell.kklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaG

IGRTGTYIITDILVklieYQGWdaeiDIQQSIRRLREFRSGMVQTDQQYKMVYQ
.|||||... ....    ..|.    .... ....|. |.|.|....|......
vgRtgtlvaaylmk....klgl....sleealalvrsrrpgavpnpgqlrfLle
PTPc_motif_SM00404 376-473 7e-07 24.2 In-house 25-110 (140) alignment 
Range on Protein: 376-473
Range on HMM: 25-110/140.0
KGQFQYILRQFRVCKGDeteRSVHQYHYKSWPdH-GvpQDPGLFLGFIEDVNRKIKDFeepGQTSGPIVVHCSAGIGRTGTYIITdilvKLIEYQGWDA
| ......   .... .   ..  ...... | .    ..   .. ... |.. |...    .. | ..||| ||. |..| ||      |..|.....
klgithvinvteevslt...kensgfqilqip.ldd..nekdklskyldkvldfiena...ekkggkvlVHCqaGvSRSatliia....Ylmryrqlsl
DSPc Dual specificity phosphatase, catalytic domain 378-502 2.4e-06 22.4 Pfam-A 18-128 (133) alignment 
Range on Protein: 378-502
Range on HMM: 18-128/133.0
QFQYILRQFRVCKGDeTERSVHQYHYKSWPDHGvpQDPGLFLGFIEDVNRKIKDFeepGQTSGPIVVHCSAGIGRTGTYIITdilvKLIEYQGWdaeiDI
......   . .. .  ...  ...| . | .   ..   .  ..|.. . |...    |  . ..||| ||| |..| ||      |......    ..
gitlvinvtkevpnn.naikkseieylripved..etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliia....Ylmktknl....sl

QQSIRRLREFRSGMVQTDQQYKMVY
.. .. ..| || ....... ....
neAyefvkerrskispnagflrqLl
DSPc Dual specificity phosphatase, catalytic domain 378-502 2.4e-06 22.4 In-house 18-128 (133) alignment 
Range on Protein: 378-502
Range on HMM: 18-128/133.0
QFQYILRQFRVCKGDeTERSVHQYHYKSWPDHGvpQDPGLFLGFIEDVNRKIKDFeepGQTSGPIVVHCSAGIGRTGTYIITdilvKLIEYQGWdaeiDI
......   . .. .  ...  ...| . | .   ..   .  ..|.. . |...    |  . ..||| ||| |..| ||      |......    ..
gitlvinvtkevpnn.naikkseieylripved..etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliia....Ylmktknl....sl

QQSIRRLREFRSGMVQTDQQYKMVY
.. .. ..| || ....... ....
neAyefvkerrskispnagflrqLl
0038934 (Phosphotyrosine protein) phosphatases II 390-506 1e-14 50.1 In-house 71-174 (194) alignment 
Range on Protein: 390-506
Range on HMM: 71-174/194.0
KGDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDfeepgQTSGPIVVHCSAGIGRTGTYIItdilVKLIEYQGWdaeiDIQQSIRRLREFRS
  .| |..  .|.   .||.|.. .  . | |.. |......     ...| ..||| ||.||||| ..      ||...|.    . ...|...|| | 
dpeefekagieylklpfpddgtvPsleillrfldlvdeflne.....dpggvvaVHCkaGlgRtGtlva....aYLiyrlgm....saeeAialfrekRp

GMVQTDQQYKMVYQIIS
|.... ........  .
gaipnqdyleallkryk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 395-516 3.8e-20 66.6 In-house 88-201 (440) alignment 
Range on Protein: 395-516
Range on HMM: 88-201/440.0
ERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIkdfEEPGqtSGPIVVHCSAGIGRTGTYIITDILVKliEYQGwDAEIDIQQSIRRLREFRSGMVQT
 |...||||..|||.|||.  |  | .|.|||      |. |  .||..|||||| ||||  |  | ...  | .    .|||   |  .|. |  ||||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq...ekag..ngpllvhcsagagrtgviiavdsilr..eakr.sdqidifsfinsmrnnrpqmvqt

DQQYKMVYQIISYYIQIREKLL
 .|| .|.. .   . . . |.
peqyafvheavlegllcgdtli
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 397-513 3.1e-13 43.8 In-house 219-348 (349) alignment 
Range on Protein: 397-513
Range on HMM: 219-348/349.0
SVHQYHYKSWPDHGVPQDPGLFLGFIEdVNRKIKDFEE-----PGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQG--------WDAEID-IQQSIR
 . |  .| |.| ..  .|  .|  .| |  .. |          . . ...|||||| ||||...  |.|. ..|           .    | |. .. 
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

RLREFRSGMVQTDQQYKMVYQIISYYIQIRE
 || .|  |||  .|. ..|. .  |.....
elrkqrismvqnlaqfiaiyealLkyfalkk
PTPc_DSPc_SM00012 398-506 4.4e-33 109.0 In-house 2-104 (105) alignment 
Range on Protein: 398-506
Range on HMM: 2-104/105.0
VHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFEEpgqtSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGwdAEIDIQQSIRRLREFRSGMVQTDQQ
|..|||..|||||||...  .| ....|... .. |.    |.|.|||||||.|||||..  |||.. .|..    |.||.| ...||. |.|||||..|
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeq

YKMVYQIIS
| ..|... 
ylflyrall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 398-512 3.5e-17 57.2 In-house 217-347 (350) alignment 
Range on Protein: 398-512
Range on HMM: 217-347/350.0
VHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKD----FEEPGQTSGPIVVHCSAGIGRTGTYIITDILVK----LI-------EYQGWDAEID-IQQSI
|.| ..| |.| ..  .|  .|  .|  |  | |         . | ||.||||||.|||||..  | |..    |        . . .    | |.. .
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RRLREFRSGMVQTDQQYKMVYQIISYYIQIR
 .||. |  |||. .|. ..|. . .| ..|
nelrkqrismvqnldqfifiYeallfyfaLr
PTEN_1 400-501 7.3e-07 24.2 In-house 96-185 (196) alignment 
Range on Protein: 400-501
Range on HMM: 96-185/196.0
QYHYKSWPDHGVPQdpglfLGFIEDVNRKIKDFEEPGQTSGPIVVHCSAGIGRTGTYIITdilvKLIEYQGWDAEidiqQSIRRLREFR-SGMVQTDQQY
.|.  ...|||.|      | .. |. .....     .  . ..||| ||.||.|| ..      |.......|.    . ....|| |  |.... .| 
eylhfpieDhgaps.....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgkltad....eAlelvrekRppgapnspsqe

KMV
. .
rll
0048567 (Phosphotyrosine protein) phosphatases II 401-501 7.3e-08 26.9 In-house 40-131 (157) alignment 
Range on Protein: 401-501
Range on HMM: 40-131/157.0
YHYKSWPDHGvPQDPGLFLGFIEDVNRKIKDFEEPGqtsGPIVVHCSAGI---GRTGTYIitdiLVKLIEYQGWDAeidiQQSIRRLREFRSGMVQTDQQ
...  . |.| | . ...  ||  .|...|..|. |   ..|.|||.||    |||.| |       || ..|...    .. |. || .| |.|   ..
vyedfffdfG.PlnlailyrFilklnkflkilelag...kaiavhckaglkkrgrtatLi....gcYlilhlgftp....eeaiaplrivrpgsvpfrda

YKMV
. ..
syll
subfamily_DSP11_pd Subfamily DSP11 405-473 9.8e-06 19.6 In-house 86-149 (178) alignment 
Range on Protein: 405-473
Range on HMM: 86-149/178.0
SWPDHGVPQDpGlflgFIEDVNRKIKDFEEPGQTS-GPIVVHCSAGIGRTGtYIITDILVKLIEYQGWDA
  | | ||..       ... ....|.| |  . .   | |||  |. ||| |.|   |..  .|.  ||
ncpGhevpke.e....lvkkfkeavkefleknkdndkligvhCthGvnrtG.yliCrylidvegyepeda
subfamily_PTEN_pd Subfamily PTEN 408-492 7.2e-06 21.1 In-house 89-164 (184) alignment 
Range on Protein: 408-492
Range on HMM: 89-164/184.0
DHGVPQdpglfLGFIEDVNRKIKDFEEPGQtSGPIVVHCSAGIGRTGTYIITdILVKLIEYQGWDAEIDIQQSIRRLREfrSGMV
||  |.     | ..|.. ..|... |  . .  .|||| || ||||. |..  |.|   ..  .  ... ...|   .  .|. 
Dhnppp.....lelleeivediekwleedk.knvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknk..kgvt
subfamily_DSP23_pd Subfamily DSP23 423-508 3.1e-07 25.2 In-house 68-145 (148) alignment 
Range on Protein: 423-508
Range on HMM: 68-145/148.0
EDVNRKIKDFEEPGQTSGPIVVHCSAGIGRTGTYIITdILVKlieYQGWDAeidiQQSIRRLREFRSGMVQTDQQYKMVYQIISYY
|.|.. ..  ||  . .  . |||  | ||||| .    |||    ..  |     ..|  .|. | | |.| .| |.|..  ...
eqvvefvrvveeaeekneavsvhcllgrgrtgtmlac.ylvk...erklaa....aeaiaevrrlrpgsvetveqeklvrdyetfi
subfamily_CG42327_pd Subfamily CG42327 432-509 4.4e-16 53.4 In-house 240-315 (319) alignment 
Range on Protein: 432-509
Range on HMM: 240-315/319.0
FEEPGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQgwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYI
     .  ||.||||| |.||||. | .|| .. .|       .|| | .  .|. |.  |.| .||...|...| | 
rsgtresqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_CDC14_pd Subfamily CDC14 437-501 2.1e-07 25.1 In-house 261-317 (328) alignment 
Range on Protein: 437-501
Range on HMM: 261-317/328.0
QTSGPIVVHCSAGIGRTGTYIITDILvKliEYQgwdaeIDIQQSIRRLREFRSGMVQTDQQYKMV
...| |.||| ||.||||| | . .. |  .|.     .  ...|  ||  | |.| . ||  ..
kaeGaiavhCkaGLGrtGtLiacylm.k..hyr.....ftaaeaiawlricrPGsvigpqqkfle
subfamily_PTPDC1_pd Subfamily PTPDC1 438-510 2.9e-08 28.4 In-house 113-177 (182) alignment 
Range on Protein: 438-510
Range on HMM: 113-177/182.0
TSGPIVVHCSAGIGRTGTyIITDILVklieyqgWDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQIISYYIQ
. | . ||| || ||||  .|. .||       .  ... ...|. .|. |.  .|| .| ..| .   . |.
qegkvavhChaGlGrtGv.liacylv.......yakrltaekaiklvrskrpksiqtreqvelvkefalflip
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 442-502 3.3e-07 24.6 In-house 1-58 (69) alignment 
Range on Protein: 442-502
Range on HMM: 1-58/69.0
IVVHCSAGIGRTGTYIItdILVKLIEYQGwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVY
.|||||.| |||||.|   |.|..   .  .  .||   .. .|  |  ||  ...| ...
mvvhcssgtgrtgtfia..imvemariks.eklvdifnnvqymrkcrpmmvmneieyifih
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 443-503 3.8e-07 24.4 In-house 1-58 (69) alignment 
Range on Protein: 443-503
Range on HMM: 1-58/69.0
VVHCSAGIGRTGTYIItdILVKLIEYQGwDAEIDIQQSIRRLREFRSGMVQTDQQYKMVYQ
|||||.| |||||.|   |.|..   .  .  .||   .. .|  |  ||  . .| ....
vvhcssGtGrtGtfia..imvemariks.eklvdifnnvqymrkcrpmmvmneneymfihd