Gene PTPN6-6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP057_AA protein Get Run
AqueP057_AA_218-510 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 6-81 2e-25 79.3 Pfam-A 1-77 (77) alignment
Range on Protein: 6-81
Range on HMM: 1-77/77.0
WFHMNLSGMDAEALLLSKGEDGSFLVRPSQNVQGDFALSVRRTKDVTHIRIQNSGDY-YDLYGGETFATLSELIQYY
|.| ..|. .|| |||....||.||||.|.. .||..|||.. ..|.|.|||.. .  | . ..|.| .|.||...|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

SH2 SH2 domain 112-187 1.7e-24 76.3 Pfam-A 1-77 (77) alignment
Range on Protein: 112-187
Range on HMM: 1-77/77.0
WYHGGITGKQAETLLMDKGLDGSFLVRASTHSPGNYVLSARVDGEVAHVIIKTQGGE-FNVGGSPSFKTLNELISHY
|||| |....|| ||.... ||.|||| | ..||.|.|| . ||.| |. |...  . . . .. .|..|.||..||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

0050432 (Phosphotyrosine protein) phosphatases II 205-511 6.3e-101 333.0 In-house 13-301 (308) alignment
Range on Protein: 205-511
Range on HMM: 13-301/308.0
PFNATSFMAKSIKDRVSELEKETGDIMGKAGFWEEFEQLQQQECrhLFSRKEGARVENKTKNRYKNILPFDHTRVVLhggD-PsivgSDYINANYISGEV
.|  ||....|.| .| .| |   . ... ...||||.|... .  |.... ....|||.|||||.|||.||.||.|   | .    ||||||.|..| .
lfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl...deg....sdYInAsyvdgys

PGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI--NETGEYGDISVQNATECINPHYIYREFIIHRIEDPsNQREVFHY
 ......|||||.||.|..|||.|.|.. ...||| |..||.||.|||.|||    ... |||...| .  | ....|..|....  ..|. . |.| |.
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthf

HFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFV
|...|||||||..|  .|.||. .....        ..|| .||||||.|||||||..|.||. . ..     ||.. |.. .| || |||||..||.|.
hytnWpdhgvPpspeilldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylfl

YRSILYHIET
|| .|.....
yralleylkl

subfamily_PTPN6_pd Subfamily PTPN6 209-517 6.5e-151 496.6 In-house 2-305 (306) alignment
Range on Protein: 209-517
Range on HMM: 2-305/306.0
TSFMAKSIKDRVSELEKeTGDIMGKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHggDPSIVGSDYINANYISGEVPGSEK
||..||.|..||||||| ... ..||||.||||.|||.|...|.||||||..|||.|||||||||||||||.|.  .||..||||||||||..||.||.|
tsllakeieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdk

HYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPD
.||||||||.||..|||.|.|||.|..|||||.|||||..|||||||  .|. |||.|||.| .|  . .||.||. ...... ...||||.||||.|||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

HGVPQDPGTVLSFLQDINSKQDELVTTgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYH
||||.|||.||.||.|.|.||.|| ..  |.||..||||||||||||||||||||......|..||.|||.....||.||||.|||||||||||..| ..
hgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

IETQRQLSE
|||...|.|
ietkkklee

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 211-511 2.7e-81 268.1 In-house 5-285 (319) alignment
Range on Protein: 211-511
Range on HMM: 5-285/319.0
FMAKSIKDRVSELEKetgdiMGKAGFWEEFEQLQQQECRhlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYISGEvpGSEKHY
.  . .|.|. .|..      |. .. .||..|.. .     . ..  . |||.||||.|||..|.|||||   |  . |||||||..| |     .. .
ievqeLkerlkalas.....tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgy..qerekf

IATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINeTGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHG
||||. | .||.|||.|.|.| | |.|| |. ||... |. .|||  |   ||| . |.   |    .|| |.. ...  .  . |||.|.....||||.
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhd

VPQDPGTVLSFLQDINSKQDelvttGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
||..  ..| .|..|.  ..     ... ||..||||||.||||||||.|. |. . .   |. .|.   .. .|.||  |||...||||.|  .|  .|
vPekatslldllkrirksre.....ktqsgPivvhCsaGvGRtGtfivldamlervke...egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

T
.
a

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 213-514 1.8e-88 291.7 In-house 4-285 (318) alignment
Range on Protein: 213-514
Range on HMM: 4-285/318.0
AKSIKDRVSELEKetgdiMGKAGFWEEFEQLQQQEcRHLFSRKEgARVENKTKNRYKNILPFDHTRVVLHGGdPSIVGSDYINANYISGEVpgSEKHYIA
.. ....| .|..      |.  . ||.|.|...| ..  | |      ||.|||| |||..||||| |.    . .|||||||||| |    ..| |||
vedleshvrrlre.....sGelllseeyerlsrse.etvtslks.lepvnkaknryanilaydhtrvkLqml.egeegsDyinanyidGyr..rkkayia

TQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRiEDPSNQREVFHYHFKAWPDHGVP
.|. || ||.|||.|.|.  |..||| |.|.|||..|..||||. ... .||.. |.   |    .|. ||| ..| .. ...|.|  ||. .|||.|||
aqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvp

QDPGTVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
......|........ | .     .. ||..||||||.||||.||..||||. . .   || ||.   .. .| ||  |||||.||.|.|  .|  ... 
esgaslldlvrqvskaqqk.....sgagpivvhCsaGvGrtGvfiavdillerika...ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

RQ
 .
dt

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 218-509 1.3e-58 193.5 In-house 9-279 (439) alignment
Range on Protein: 218-509
Range on HMM: 9-279/439.0
DRVSELEKETGDImgkagFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEVpgSEKHYIATQGCL
. | .|.|.  .|     | |.||...  .  .       |.  ..||||||.. .||||||.|.   | .  | ||||||| |     .| ||||||  
ehvekldknkqei.....fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqe.ipgvphshyinanyikGyy..ddklyiatqgpk

PTTINDFWKMIWQESSQIIVMTTNEVERGRnkcarYWPGINETgEYGDISVQNATECINPHYIYREFIIHRIEDPS-NQREVFHYHFKAWPDHGVPQDPG
  | .|||...... .  ||| || ||  .     |||  .|.  ||||.|.   .   |.|. | | .    | . ..| |...|. ||||. || .  
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas

TVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
 || ||. ||| .|.     .| ||..||||||.||||| | .|| |.   |   |  |||.  ....| ||  |||.  || |.| ..|  |
hvldflrainsandk.....eeygpvvvhcsagvGrtGtiialdiale...qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

0039614 (Phosphotyrosine protein) phosphatases II 219-511 3.6e-92 304.2 In-house 17-291 (297) alignment
Range on Protein: 219-511
Range on HMM: 17-291/297.0
RVSELEKETGDIMGKAGFWEEFEQLQQQECrhlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYIsgEVPGS-EKHYIATQGCL
.| .| .   . ..| ....|||.|... .    ........|||.|||||.|||.||.||.|.. | .  .||||||.|.  ...    ...|||||.|
svldlllllekansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPl

PTTINDFWKMIWQESSQIIVMTTNEVERGRnKCARYWPgiNETGEYGDISVQNATECINPHYIYREFIIHRiEDPSnqREVFHYHFKAWPDHGVPQDPGT
| |..|||.|.|.. ...||| |..||.|| |||.|||  .|.|.|||..| . ..  ...|..|.. . . ...|  |.| |...  |||||||... .
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywp..eeggtygdftvtllkvehldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslel

VLSFLQDINSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
.|.||. ... . ||    ...|| .||||||.|||||||.....|. .       .||.. |.. .| ||.|.|||..||.|.|. .|... .
lleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkr

0036941 (Phosphotyrosine protein) phosphatases II 223-514 2.9e-95 314.2 In-house 2-282 (297) alignment
Range on Protein: 223-514
Range on HMM: 2-282/297.0
LEKETGDIMGKAGFWEEFEQLqqQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLhgGDpsiVGSDYINANYIsgEVPGSEKHYIATQGCLPTTIN
|.|   .....|....|||.|  ... .|.|.. ....||..|||||.|||.|||||.|  .|    |||||||.|.  .... ....|||||.||.|..
llkllekllflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl..dd...egsdYinAsyv..dgydlkrkfIatqgPlpntve

DFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI-NETGEYGDISVQNATECI--NPHYIYREFIIHRIEDPsNQREVFHYHFKAWPDHGVPQDPGTVL
|||.|.|.. ...||| |..||.||.|||.|||   .|. .|||..|.. .. .  ...|..|.. .  .... ..|.| |.|.. |||||||..| ..|
dFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespasll

SFLQDINSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
.|.. .......|    ...|| .||||||.||.||||..|..|. . ..  |  |||  |.. .| || |.|||..||.|.|. .|... ....
dfielvrkvlkll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

subfamily_PTPRG_pd Subfamily PTPRG 224-514 5.8e-79 260.8 In-house 7-292 (563) alignment
Range on Protein: 224-514
Range on HMM: 7-292/563.0
EKETGDIM--GKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGdPSIVGS-DYINANYISGEVpgSEKHYIATQGCLPTT
.|   ..   |. || ||||.||..   . .  .   . ||| |||| ||...|..|| |..  | . .. |||||||| |     .| .||||| |..|
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklspl.pgkkkklDYinAnyidGyq..kskafiatqgplkdt

INDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHR--IE---DPSNQREVFHYHFKAWPDHGVPQDP
..|||.|||.. ..|||| || |||||.|| .|||  .|. .|| ..|.  .| .   |  |...|.   ..   .  ....| .||.  |||||||. .
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs

GTVLSFLQDInskqdeLVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
  ||.| .          .. .| ||..||||||.|||||.||.| ||. . |   |  |.. . .. .||||  .|||| || |..  .|  | .. .
lpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq...enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 227-511 8.5e-63 206.9 In-house 13-285 (290) alignment
Range on Protein: 227-511
Range on HMM: 13-285/290.0
TGDIMGKAGFWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLH--GGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDF
.| . |. || ..|..|.. |  |  . . |   .||..||..||.. |  |..|.  .|..     .|||| || |     .|.|||||| .. |. ||
nghakgnegfrnqfkmldsgeseh..tvtvgltssnkllnRfanivvyddnritLrpisghkD.CtneyinAcyikgy..kekkqyiatqgpvsntlvdF

WKMIWQESSQIIVMTTNEVERGRNKCARYWPGInETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQD
||.||||.. |||| ||..| |..||  |||   .| .|| .|..   | .  .|| |.. ..  .   ....| .|....|...|  ..| |.|. .. 
WkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillviee

INSKQDElvtTGNepGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
.. .|     .||  ....||||...||...|..... .| . .   |  .|.   ..  | |. |.|||.|||..... .|  ...
myktqrk...rgn..tsivvHCSdtvgrsavfcaaattinkckt...egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 227-515 7.6e-59 194.0 In-house 13-284 (287) alignment
Range on Protein: 227-515
Range on HMM: 13-284/287.0
TGDIMGKAGFWEEFEQLQQ-QECRHLFSrkEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgsDYINANYISGEvpGSEKHYIATQGCLPTTINDFW
.|   |. || . |  |.| .. ..      .   .|| |||...||. |  ||.|.| .|     ||||| .| |    ..|..|.... .  |. .||
kghakgnegfknqftvleqvtqredevt..hniasqnkdknRltqilvpdnyrvllkgehp.....dyinavfidgy..kekkafiiaesPmfntarnfW

KMIWQESSQIIVMTTNEVERGRNKCARYWPGINEtGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
|.|...  ..||| ..| |  ...| .|||  .    .|. ...   | .| .|| |.. ... .  .....|  |.. .|...|  ..| |.|  ... 
kliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

NSKQDElvtTGNepGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
. .|      ||  ....||||...||...|. ... .|   ..|    .|. . ..  | |. |.||| .||||..  .| .... .  
yktqrk...rgn..tsivvhCsdtvGrsamfcaaattinkckteG...viDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

0047943 (Phosphotyrosine protein) phosphatases II 228-509 1.2e-90 299.0 In-house 6-272 (273) alignment
Range on Protein: 228-509
Range on HMM: 6-272/273.0
GDIMGKAGFWEEFEQLqqQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLhggdpSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKM
 .  |.....||||.|  ... .|.... ....|||.|||||.|||.||.||.|     .  |||||||.|.  ... .....||||| || |..|||.|
ekllgltllleefell..lslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrm

IWQESSQIIVMTTNEVERGRNKCARYWPGINE--TGEYGDISVQNATECINPHYIYREFIIHRIEDPSnQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
.|.. ...||| |..||.||.|||.|||  ..  . .||...| .  | ....|. |.... .....   |.| |.|.. |||||||...  .|.|....
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielv

NSKQDELVTTgnepGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.... .|.      || .||||||.|||||||..|.||. .   |    ||.  |..|.| || |||||..||.|.|. .|...
rkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPN23_pd Subfamily PTPN23 228-511 7.4e-69 226.7 In-house 9-282 (288) alignment
Range on Protein: 228-511
Range on HMM: 9-282/288.0
GDIMGKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHggdpsIVGSDYINANYISGEVPGSEkHYIATQGCLPTTINDFWKM
. . ||... ..|..|.|.. ..  .|   .   . .|||...|||.||.||.|.         ||||| .. . .||.  ..||||. |..|.||||.|
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlm

IWQESSQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQNATECINPHYIYREFIIHrIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDIN
.... |..||| ... |.|..|..||||   .|| ..||.||    .   .... |..... ..|... ..| | ....||..|||. |.|.| ||. ..
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle.tldadavksvshlqltsWpelGvPasPetllqfldeve

SKQDELVTTGNEpgPLIVHCSAGIGRTGTFIVID-ILLNVMMQQGFEadvDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
|. ..     .   ||.||||||.||||.| ..  .. ..  ..|     || . .. .|.||  |||...|.||.|  .| ... 
sayeavqrkskt..PlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 229-510 3.2e-81 267.5 In-house 16-280 (288) alignment
Range on Protein: 229-510
Range on HMM: 16-280/288.0
DIMGKAGFWEEFEQLQQQEcrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMI
. ....|| ||...| . |  .  | . | . .|..||||.||||.|..|| |....    |.|||||.|| ||  ...|.|||||| |. |.||||...
sarnrtgfseeynsLaale..ktksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyidge..kkkkkyiatqgPladtvndfWelv

WQESSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHrieDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
... .. ||| |. ||.|..|| .|||  ..  .||.. |.   .    ... |.....      ...|. .|...||||||||..   .| .|. ..  
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkva

QDELvttgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
...        ||.|||||||.|||||||..| |.. . .   |  .|.  ... .| ||  .|||..|| |.|. .|  ||
nqad......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie

subfamily_PTPN9_pd Subfamily PTPN9 230-511 2.4e-77 254.9 In-house 12-292 (297) alignment
Range on Protein: 230-511
Range on HMM: 12-292/297.0
IMGKAGFWEEFEQLQQQECRHLFSRKEgaRVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIW
 .|| |  .|........    | . .     | .||||...| .|.|||||   |     |||||||.. |     .| .||||| |. |..|||.|.|
ekgkrGlskeyaeirnepveGtflask..lranleknrytdvlcydetrvvlakvded.easdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvW

QESSQIIVMTTNEVERGRNKCARYWP-GINETGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
...  .|||||  ||||| ||..||| . ... |.||.||.|     . .|  | . |..... ...|.| |. | .|||.|||..  ..| .|. . .|
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrek

QDELVTT------GNEPG-PLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
|  .|..      |.  | |..|||||||||||||| .|| |. . .   .. ||.. ...|.|.||. ..||..||.| | ..| .  .
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee...vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

0040438 (Phosphotyrosine protein) phosphatases II 231-512 3.5e-95 314.2 In-house 15-279 (317) alignment
Range on Protein: 231-512
Range on HMM: 15-279/317.0
MGKAGFWEEFEQLQQQecrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQ
... ...||||.|...   .| ........||| ||||..|||.||.||.|.  .. . .||||||.|.  ..|   ...|||||.|| |..|||.|.|.
sdftalleefedllsl...kldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvwe

ESSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIeDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQD
. ...||| |...|.||.|||.|||  .|| .|||..|..  |  ......|.. .    . |..|.| |.|...|||||||..| ..|.||. ......
qgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale

elvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
      ...||..||||||.|||||||.....|. . . |   .||.. |.. .|.||.|.|||..||.|.|. .|... . 
......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 231-510 7.7e-75 246.9 In-house 24-291 (298) alignment
Range on Protein: 231-510
Range on HMM: 24-291/298.0
MGKAGFWEEFEQLQQQEC-RHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpGSEkHYIATQGCLPTTINDFWKMIW
.. .|. .||..|.. .   . .. . . . ||| |||| .|...|..||||.  | .   |||||| ....   |..  .||||. |..|..|||.|..
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhayk.grn.afiatqaPltetvedFWrmvt

QESSQIIVMTTNEVERGRNKCARYWPGInETGEYGDISVQNATECINPHYIYREFIIHRIEDPsNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQ
.| .. ||| || .| .. |. .|||   .. .||.|.|.   .     .| |...... .   ..||| . ||  |||.|||.   .|| .|.... .|
eedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasq

DElvtTGNEpgPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
 .   .||.  |.||.||||.||.||||.|| .|. . .   |  ||. .... .|..| |.||||.||.|.|  .|  ..
qq...agnk..pvivqCsaGvgRsGtfiaidsvlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_PTPN14_pd Subfamily PTPN14 231-511 1.9e-70 232.3 In-house 20-298 (300) alignment
Range on Protein: 231-511
Range on HMM: 20-298/300.0
MGKAGFWEEFEQLQQQECRHLFSrkEGARVENKTKNRYKNILPFDHTRVVLHGGDPSivGSDYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQ
. ..  . |.|......   |.|   ..  ||. |||.|..||....|| |     .   ..||||  |.  | |.|..||..|| |..|..|||.|.|.
leegkvfteyeripkkredalls..taklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

ESSQIIVMTTNEVERGRNKCARYWPGI---NETGEYGDISVQNATECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINS
.  |.||| |.| | |..|. .|.|     ..| |.|   |..      . .| . . .. .   ...|.|.|  .. |||||||.|. . ||.|....|
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

KQ---DELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
 .   .. | . ..  |..||||||.||||  |. |.|.. . .   . ..||..... .| ||  .|||  ||||||. .. ... 
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_PTPRD_pd Subfamily PTPRD 232-514 3.2e-99 328.1 In-house 21-286 (564) alignment
Range on Protein: 232-514
Range on HMM: 21-286/564.0
GKAGFWEEFEQLQQQecrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQE
... | ||.......   . |. .. .  .|| ||||.||...||.||||.  .    |||||||..| |    ..|.|||||| |..||.|||.|.|..
sdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweq

SSQIIVMTTNEVERGRNKCARYWPGINeTGEYGDISVQNATECINPHYIYREFIIhRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdE
 |..||| |. .|.|..||..|||  . | .||.. |.   |    .|. |.|.. . .. |..||| ..|| .|||||||. . ..|........ . |
nsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e

lvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
     .. ||..||||||.||||||||||..|. . .   |..|||   ....|.||  |||||.|| |... ||  .. . .
.....pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

0045450 (Phosphotyrosine protein) phosphatases II 232-509 2.5e-96 318.3 In-house 25-304 (307) alignment
Range on Protein: 232-509
Range on HMM: 25-304/307.0
GKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISG------EVPGSEKHYIATQGCLPTTINDFW
...|...|||.|.......|.........|||.|||||.|||.|||||.|.  |.|. .||||||.|.        ... . ...|||||.|| |..|||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

KMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
.|.|.. ...||| |..||.||.|||.|||  .|. .||.. | .  | . ..|..| . ... .  .. |.| |.|...|||||||... ..|.|.. .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

NSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.. ..||    ...|| .||||||.|||||||.....|  . ..|   |||.. |..|.|.||.|.||...||.|.|. .|...
rkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0051299 (Phosphotyrosine protein) phosphatases II 232-509 3.9e-95 313.9 In-house 21-286 (288) alignment
Range on Protein: 232-509
Range on HMM: 21-286/288.0
GKAGFWEEFEQLQQQECRhlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYISGevPGSEKHYIATQGCLPTTINDFWKMIWQE
|..|..||||.|... .   .... ....||..||||..|||.||.||.|.  |. . |||||||.||.|  . .....|||||.||.|..|||.|.|..
gltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvweq

SSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIE---DPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
 ...||| |..||.||.|||.|||  ... .||||.| .  | ....|..|.... ...    ... |.| |.|...|||||||..|  .|.||......
nvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

QDelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.       . .|| .||||||.|||||||..|.||. . ..     ||. .|.. .| || |||||..||.|||. .|...
la......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 232-509 2.6e-89 294.7 In-house 18-277 (278) alignment
Range on Protein: 232-509
Range on HMM: 18-277/278.0
GKAGFWEEFEQLQQQECrhlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQE
.|.....|||.|...     .... ....|||.|||||.|||.||.||.|.  ...  .||||||.|.  ...   ...|||||.|| |..|||.|.|..
lktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsl.lggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwel

SSQIIVMTTNEVERGRNKCARYWPgiNETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNqREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDe
 ...||| |..||.||.|||.|||  ... .|||..| .  |  ...|. | . ...  |.   |.| |||...||||||| .. ..|.||........ 
gvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.

lvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
     ...||..||||||.|||||||....||. ..  |    ||.. |.. .| || |.|||..||.|.|. .|...
.....dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPN12_pd Subfamily PTPN12 232-514 1.7e-82 271.6 In-house 6-282 (290) alignment
Range on Protein: 232-514
Range on HMM: 6-282/290.0
GKAGFWEEFEQLQQQECR----HLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIvGSDYINANYISGevPGSEKHYIATQGCLPTTINDFWKM
|.. | .||..|.... .    . .|...| . ||..|||||.|||.|..||.|.  . .  ||||||||.| |  . ....|||.|| ||.|..|||.|
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikg..vegkleyiaaqgPLpktlddfWrm

IWQESSQIIVMTTNEVERGRNKCARYWPGINETGE-YGDISVQNATE-CINPHYIYREFIIHRIedpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
||. . .|.||  .||| |..||.||||  .|.   .|...|.. .|  ..  .. | . ...    ...|.|  .|..||||||||. . ..|......
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielv

NSKQDelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
.. |.      .|  ||.||||||.||||| |.||.  ... ..  . ..|.   .. .| ||. .|||..||..||....  .... .
relqe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 232-506 2.3e-61 202.7 In-house 21-285 (325) alignment
Range on Protein: 232-506
Range on HMM: 21-285/325.0
GKAGFWEEFEQLQQQECRhlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMI--W
 . ||  ||. |  ..     ..|  .. ||| |||.||....|..||||   . .   ||||||.|.  ..    . ..|.|  |..||||.|...  |
dqdgfahefgllpsddgi...akkvamkpenkaknrfknvvaldksrvvletkkdd.pssdyinasylrddk..kkdvflaaqaPltatindlWrlvldW

QesSQIIVMtTNEVERGRNKCARYWPGI-NETGEYGDISVQNAT-ECInPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINS
.  . ..|. .||.. | ..|| |||    .. ..| . |.  | | |   |..| . . ....  . | |  .....|.| ||.. | |..|.|| .. 
r..csvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvka

KQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .. . .  .  .|..||||||.||||.|| .  .|. ...   |. |||   .. .|..|  ||.|  || ..| .. 
vservtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdqyiliyealv

subfamily_PTPRB_pd Subfamily PTPRB 233-513 7.4e-88 289.4 In-house 24-289 (293) alignment
Range on Protein: 233-513
Range on HMM: 24-289/293.0
KAGFWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQES
...| ||.|.|.. .  .  . |   . .|..||||.||||.||.|| |.  . .  ||||||||||.|    |....||||| ||.|..|||.|.|.. 
dlrfseeyeelkavgkdq..avkaaelavnraknrytnilpydhsrvkLaalk.desgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwekk

SQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRiedPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDEl
|.|||| |. ||.|. || .|||  .|.  ||||.|.  .|    ... ||. |..    ...|.| .|||..|||||||... |.|.|.. ....... 
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek.

vttGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
    .. .|..||||||.||||||| .| ||. . .   |  |||   .. .| .|  .||||.|| |.....|  .....
...taskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 233-512 1e-77 256.1 In-house 14-279 (281) alignment
Range on Protein: 233-512
Range on HMM: 14-279/281.0
KAGFWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQES
.||| ||.|.|.. . ..  . .   . ||..||||.||  .|.|||...  . .   .||||||...|    .||.|||||| .|.....||.|.|...
naGfieeyeklaaigvdn..tataskadenvlknrYsnivaYDatrvkvtpne.enkntDYinanfvpgy..kgekeyiatqgPvPaslvafWqmvweqk

SQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIhrIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDEL
 ..||| |.|.| |. || ||||  |.. .|||. |.. .|  ...|| |.| .   .. ...||| . ...||||||||...  .|.| ..... ... 
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

VTtgnepGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
        ||..|||||.|||||.| .| |.. . ..  ....|..  .. .| .|  ||||  ||.|||. .|  .. .
tk.....aplvihCsaGvGrtGtyialDrlvkaveae..leeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_Ptp69D_pd Subfamily Ptp69D 233-510 1.1e-72 239.8 In-house 21-287 (307) alignment
Range on Protein: 233-510
Range on HMM: 21-287/307.0
KAGFWEEFEQLQQQecRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGdPSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQES
. |. .|.|.|...      | | ... ||. ||||..| .||.|||.|.   .    ||||||..| |     .|..|| |. . .||.|||.||.. .
dfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkki.ngkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmiaeqe

SQIIVMTTNEVERGRNKCARYWPgINETGEYGDISVQNATECINPHYIYREFIIHRIEDP----SNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
...||| .|. |  |.|||.||| |... .|||| |. . |   ..|| ||. . ....      ..|.|  ||...|.|  ||. . ..| ... ... 
vtlivmlsnlteknrkkcakYWp.iedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

QDELvttgnePGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
.          .|..|||||| ||.|.|. .|.||.   |.  |  |||   .. .| ||. .||  .||.|.||..| ...
ykln......rsPivvhCsaGvgrsgifvaldsllq...qlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 233-513 2.3e-69 228.9 In-house 21-287 (305) alignment
Range on Protein: 233-513
Range on HMM: 21-287/305.0
KAGFWEEFEQLQQQECRHLFSRKEgarvENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQES
. |. .....|...|      .||    .||.|||.|.| ..|. |. |   ..|   ||||||.|. |    ..|.||..|| |..|..|||..|..| 
dkgleaqykslyeeeesidvgkke....ankaknrlkeitlldddriilte.keslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveek

SQIIVMTTNEVERGRNKCARYWPGINET-GEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDE
 . ||| |. || |..|| .|||.      |.|..||.   |   . || |.. |   .. ...| | .|..  |||||||| ....||...... .| .
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

lvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
     ..  ||.||||||.||||.||..|| |. . .   |  ||. . .. .| .| .|||| .|| |..  .   |..  
.....dkgvpllVhCsagvgRtGvfiavdialerlkk...EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 233-506 5.3e-59 194.7 In-house 23-276 (315) alignment
Range on Protein: 233-506
Range on HMM: 23-276/315.0
KAGFWEEFEQLQQQECRHLfsrKEGARVENKTKNRYKNILPFDHTRVVL--HGGDPsivGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQ
| || ...| .   . . |   .   ..||| |||| ||...|..|| |     ||   .|||.|||.| |     ...|||.|| ......|||.....
kngfkqdyesipggqlhpl...dvakkienkqknryiniiaydksrvqlpllendp...hsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfe

ESSQIIVMTTNEVERGRNKCARYWPGIneTGEYGDISVQNATECINPHYIYREFiihRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQD
|    ||| || ||. ..|. .|||       || |.|    | .| .|  | .    .   .| |||. .|. .||| |||.   ... . . ..  ..
edigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht

ELVttgnepGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
. |      |...||||||.||||||| .| .|.   |   |  .|. ..|. ||..| .|||. .||.|.|  .|
nsv......gaivvhcsaGvGrtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_PTPRA_pd Subfamily PTPRA 234-512 1.6e-74 245.8 In-house 32-299 (330) alignment
Range on Protein: 234-512
Range on HMM: 32-299/330.0
AGFWEEFEQLQQQECRHLFsrKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESS
  | |||. |   . .  .  .  .. ||| |||. ||||.|..||.|   .  .  |||||| .| |      ...||.|| .  |..|||.|||.  |
klfreefnalPagpiqatl..elaskeenkeknrvvnilPydfsrvilsvke.GveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqks

QIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIEDPS---NQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQD
. ||| |.  || ..|||.|||  . .  ||.| |.   | .  .|  |.|..... | .   ..| |  .||..||| ||| .|  .|..|. ......
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

ElvtTGNepgPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYH-IETQ
    ...   |..||||||.||||||||.| .|. .     |  ||. .... .|.||. ||||..||.|.|. .| . .  .
q...sag...pivvhcsaGvGrtGtfivldavlervka...erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd

subfamily_PTPRK_pd Subfamily PTPRK 234-507 1.8e-71 235.5 In-house 22-275 (314) alignment
Range on Protein: 234-507
Range on HMM: 22-275/314.0
AGFWEEFEQLQQQecrhlfsRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESS
 || ||.| | .             . ||..|||...||..|..||.|.  |     ||||||..| .      ...|.||| |. |..|||.....| .
ygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgd.pssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydenc

QIIVMTTNEVERGRNKCARYWPgiNETGEYGDISVQNATECINPHYIYREFIIHRIEDP-SNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDEl
  ||| |. || || || .|||  ..|  |||| |.     ..  .. | | ..... . ...||| ...| .||||.||.   ..|.... ....|.| 
asivmltelvevgrvkClkyWP..edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.

vttgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY
     | |...|||||| |||||||.|||.|... ..|    ||.  |.. .|.... ||.||.||||.|  || 
.....eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 234-510 1.8e-51 169.6 In-house 15-294 (301) alignment
Range on Protein: 234-510
Range on HMM: 15-294/301.0
AGFWEEFEQLQQQECRHlfsRKEGARVENKTKNRYKNILPFDHTRVVLHGGDP-SIVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQES
 .| |....|...| ..    . | . |||. ||.||| ..|. |..|.     ..   .||||.||.|    ..|..||.|| .  |. |||..|||| 
nkfeeqykelkegedks...ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqek

SQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQNATECINPHYIYREFIIhRIEDPSN---------------QREVFHYHFKAWPDHGVPQDPG
 . ||| ||. |. ..|| .|||   .|. |.| ..|.   |.. | .. |.. . .|.| ||                ..|  ..   ||..|| ..| 
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnv.kiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TVLSFLQDINSKQDELvttgnEPGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
|||  ..|.  .|        . ||..||||....|.|... ..| |    |   |  ||.   .. || .. |.|.| .|| ..|  |   ..
tvLqviddvihrqqki.....gggpvvVHCSdtVsrsGvYcsvsiglE...QckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 234-515 1.2e-46 153.9 In-house 20-242 (392) alignment
Range on Protein: 234-515
Range on HMM: 20-242/392.0
AGFWEEFEQLQQQEcrhLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESS
| | ||| .| . .   .. .. . .  |. |||||||||.| .||.|   |  |  |||.|| || .    .|| |||.||  .....|||.|..||  
alffeefhdlpgpd...iypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqenv

QIIVMTTNEVERGrnkcarywpginetgeygdisvqnatecinphyiyrefiihrieDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelv
  |.| |.  |                                                 ..| |  .||  |||..||.   ..| |.......     
ttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf....

ttGNEPGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
  |.   |||.|||||.||||  | || ..    .      ||.   .  .| .|  ||||..|| |.| ..|  .  .  |
..Gqythpliihcsagvgrtgvvisidsvva...hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntl

0046845 (Phosphotyrosine protein) phosphatases II 235-512 1.1e-99 328.7 In-house 1-277 (284) alignment
Range on Protein: 235-512
Range on HMM: 1-277/284.0
GFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISGEVP---GSEKHYIATQGCLPTTINDFWKMIWQE
|..||||.|... . .|.|.. ....||..|||||.|||.||.||.|.  |... .||||||.|..|       ..|..||||| ||.|..|||.|.|..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

SSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDE
 ...||| |..||.||.|||.||| ..|. .|||..| .  | ....|..|.. . ... ... |.| |.|...|||||||..|  .|.||..... ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

lvttGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
     . .|| .||||||.|||||||..|.||. . ..|  . ||.. |.. .| || |||||..||.|||. .|... . 
....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

subfamily_PTPN1_pd Subfamily PTPN1 235-509 1.1e-66 219.5 In-house 6-271 (290) alignment
Range on Protein: 235-509
Range on HMM: 6-271/290.0
GFWEEFEQLQQQECRhLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgsDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQ
 ...|. .  ..|..  |. .|  . ||...|||... |.||.|..|. .|      |||||. .  |..  ...|| ||| || |.. ||.|.|.. |.
rlykeiyldirkeas.dfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslv..eleeakrsyiltqGPlpntvdhfWqmvWeqksk

IIVMTTNEVERGRNKCARYWPGINETG--EYG--DISVQNATECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQd
 .||  . ||....|||.|||  .|.   ..    ..|.  .| .. .|. | . .. ..   . ||..|.|. .||| |||. |.. |.||... .   
avvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresG.

elvTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
   .  .. || ..||||||||.|||...| .|  . ...  . |||.. .  .| .| |..|| .| .| | .||  .
...slssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa

DSPc_SM00195 236-509 2.3e-89 294.6 In-house 2-262 (263) alignment
Range on Protein: 236-509
Range on HMM: 2-262/263.0
FWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQI
..||||.|....  .  . .|... .||.|||||||||.||||| |.  . .  ||||||||||.|.   ..|.||||||.||.|..|||.|.|.| ..|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

IVMTTNEVERGRNKCARYWPGI-NETGEYGDISVQNATECINP-HYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELv
|||.|.|.|.|..||.||||   ... ..|.|||..  . . . ..| |.. .   .. ...|.| .|..|.|||||||...  ||..|. .......  
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

ttgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
      ||..||||||.||||||..|||.|. . ..     |||.  .. .| || |||||..||.|.|. ||. |
.....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 236-509 2.3e-89 294.6 In-house 2-262 (263) alignment
Range on Protein: 236-509
Range on HMM: 2-262/263.0
FWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQI
..||||.|....  .  . .|... .||.|||||||||.||||| |.  . .  ||||||||||.|.   ..|.||||||.||.|..|||.|.|.| ..|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

IVMTTNEVERGRNKCARYWPGI-NETGEYGDISVQNATECINP-HYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELv
|||.|.|.|.|..||.||||   ... ..|.|||..  . . . ..| |.. .   .. ...|.| .|..|.|||||||...  ||..|. .......  
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

ttgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
      ||..||||||.||||||..|||.|. . ..     |||.  .. .| || |||||..||.|.|. ||. |
.....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 236-515 3.6e-61 201.7 In-house 21-283 (315) alignment
Range on Protein: 236-515
Range on HMM: 21-283/315.0
FWEEFEQLQQQECrhlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQI
| ||| .| . .    . .. .   .| .|||||||||.|..||.|   |  .  |||||| || .    ..| |||.|| |.....|||.|..||    
fseefhdlpdPdi...yrqrvaretinfkknryknilPldsarvklevidd.sPdsdyinasyiksv..dddkayiasqgPlkasvddfwrmvlqekvtt

IVMTTNEVERGRNKCARYWPG-INETGEYGDISVQNATECINPHYIYREFiIHRIEDpsNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvt
||| |.  |  . ||..|||    .. |.| |.|.      .   . |.. . |  .  ..| |  ..|. |||.||... ...| ..... ...     
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkadn.....

tGNEPGPLIVHCSAGIGRTGTFIVIDillNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
 |..  .|.||||||.|||| .| ||   .|. |   .  ||. . .. .||.|  .||||..| |.| ..| ..  .  |
.gkkefsllvhcsaGvGrtGvvisid...evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 236-517 2.1e-38 126.6 In-house 13-277 (281) alignment
Range on Protein: 236-517
Range on HMM: 13-277/281.0
FWEEFEQLQQQECRHLFSRKEgARVENKtKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISGevPGSEKHYIATQGCLPTTINDFWKMIWQESSQI
| .|| .|  .    | .  .   |.|| |||| ||  .| .|| |.   |    .||| ||||    |  .. || |||    |  |||.||||| .  
fkqefsnlpgdppsdlctvfn.qpvnnk.knrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwrmiwqentta

IVMTTNEVERGRNKCARYWPGINET-GEYGDISVQNATECINPHYIYREFIIhriEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvt
|||  . .|  |.||| |.|       ..  .||.     .|   .   . .       . | . |. .| |||  ||.    .|  |. | ..      
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl...syegetrlithwlwkewpdwqvpessevmlkilrkirars.....

TgnepgPLIVHCSAGIGRTGTFIVIDILLNVMMQQgFEaDVDIQRAIQLVR-AQRSGMVQTEQQYKFVYRSILYHIETQRQLSE
|     | ..|||||.||.||.. ..| |. .  . |    ||.. .  .| . |.  ||| ||| .... .|    . .|..|
t.....ppvihcsagvgrsgtlmaveialqsihsh.ft.lpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqite

subfamily_PTPN13_pd Subfamily PTPN13 237-510 6.8e-75 246.8 In-house 14-270 (273) alignment
Range on Protein: 237-510
Range on HMM: 14-270/273.0
WEEFEQLQqqECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgsdYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQII
 |||..|.  | . | . ..| . |||.||||.|.||.|.||| | .  .      ||||..|  .|   | .|||.|| ||.|..|||.|.|. ....|
aeefkelr..elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMTTNEVERGRNKCARYWPGINE--TGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvt
.| |.|.|.|. || |||| ...  .  .. . |..        .  |.. .. .|  .. ||| | .| .|||||||. .  .| |.. ... |.    
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....

tgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
   . ||..|||||||||.||.|.||..|... ..    ..|..  .. .| || |.|||..|| |||..||. ..
...dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_CG42327_pd Subfamily CG42327 237-428 1.2e-34 114.4 In-house 8-193 (319) alignment
Range on Protein: 237-428
Range on HMM: 8-193/319.0
WEEFEQLQqqecrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEVpGSEKHYIATQGCLPTTINDFWKMIWQESSQII
 |||..|       | .| .   |  | |.|. |..|. .|||||.   ..   . |..|.|. |    .. .|||.|  |  .  |||...|.  |..|
aeefrdlP.....qliaradevPvtskdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvi

VMTTNEVERGRNKCARYWP---GINETGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFkAWPDHGVPQDPGTVLSFLQDINSK
|  |.  | | ..||.|.|   . ..|  |||| |      .. .|.   ....|... .. ||. || .  |.. .|| .. .... | ...| 
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 238-515 9.4e-58 190.3 In-house 14-283 (287) alignment
Range on Protein: 238-515
Range on HMM: 14-283/287.0
EEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIV
.|...|..      .  |.   . .  |||| ..||.|.|||.|   ..   |||||||||...     .. .||.|| ...|..|||...... |  ..
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.ege.lGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsasvi

MTTNEVERGRNKCARYWPGINETGEYGDISVQNA-TECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkQDELVTTG
. | ||| .|.|| .|||  .     |  ||     .  .|.|  | . .  .|   . | |  ... .|||....     .. |  |..  . ||   .
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkq.hielarda

NEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
.| |||.||...||||.|... . .|.. . . |    ||. ...  .| .| ..||.  |....| ..  . .|. ||
sevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyyktnpql

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 238-512 4.4e-44 145.7 In-house 20-281 (307) alignment
Range on Protein: 238-512
Range on HMM: 20-281/307.0
EEFEQLQQQECRHLFSrkeGARVENKTKNRYKNILPFDHTRVVLHGGDpsiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIV
.||..| ...   .      |   |  ||||...   |..|.|..      . |||| |||.   .    |..|..|| | .|. .|| |. ||  . ..
defrvlakktpegvtv...eafsantdknryqdvkcqdkgrivvkfdg...lasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvi

MTTNEVERGRNKCARYWPGINE-TGEYG----DISVQNA-TECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDe
|  . .| .. || .|||  .  .  .|     |||.|  .. . |   . .    ...  .. | . |. .. |||.||||   | . .|. .. ... 
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.

lvttgnepgPLIVHCSAGIGRTGTFIVIDILLNVMMQqGfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL-YHIETQ
         |..||||||.||.|| . | .. . |.. | .   |... .. .|.||   .||| || ...| .| | .|  
.........pvvvhcsaGvGrsGtivaislvqdkmia.G.inckdmkklveelrsqrhyaiqteaqylylhrvlleyflely

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 238-302 1.1e-10 35.6 In-house 17-77 (244) alignment
Range on Protein: 238-302
Range on HMM: 17-77/244.0
EEFEQLQQQeCRHlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpsIVGSDYINANYISGE
|||  | .. .|. | . .     | ||||| ||||||.|||.|        |||||||||| | 
eefvglsdh.tre.flqtnavlsanatknryinilpfdetrvilsssk..kegsdyinanyiqgs

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 239-506 5.5e-50 164.8 In-house 11-263 (283) alignment
Range on Protein: 239-506
Range on HMM: 11-263/283.0
EFEQLQQQECRHLFSRKEGARvENKTKNRYKNILPFDHTRVVLHGGDPsivgsDYINANYIS-GEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIV
 .|.|..    .| .  . |. |||.|||...|.| |  || |.   .     ||||| .|   .    .| ||..|. |  |. |||||...|    ||
frevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGvPQDPGTVLSFLQDINSKQDElvttgN
| |.  |  | ||..|||  . . .||.  |    |  .  .| .|....      ..  . || .  | . | .| .   |  .  . |.| |     .
mltklqedlrikCsqyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqte.....s

EPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
. ||..||||.|||||..|| .   .. ..    |. ||.   .. .| || ..||| .|||.|.  .|
kkgPivvhCstgiGrtavfiaasasvkdalt...esvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_CG7180_pd Subfamily CG7180 243-510 5.8e-46 151.5 In-house 29-291 (296) alignment
Range on Protein: 243-510
Range on HMM: 29-291/296.0
LQQQECRHlfsrkeGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNE
|.. .|..      | | ||. |||. ...|.|..||||.  |     |||||| |. . .   .| || |..    |...||.....| .. .|. |..
leigdCag......glrkenreknrdvkvvPyDynRvvLekldGe.eksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtkt

VERGRnKCARYWPGINeTGEYGDISVQNATECINPHYIYREFIIHRI---------EDPSNQREVFHYHFKAWPD-HGVPQDPGTVLSFLQDINSKQDEL
 .  . ..  |||      .||.| |.  .|   ..   |.| . .          .   ..| | ..... |.  . ||    ... ... ... ... 
fdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

vTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
    .| ||..|..| | .|.| .. ||. |. . ...    ||. .|.. .| .| ..|.. ..||..|  .| .. 
.dedpeegPvvvvssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_eak_pd Subfamily eak 249-513 7.8e-25 81.9 In-house 39-309 (332) alignment
Range on Protein: 249-513
Range on HMM: 39-309/332.0
RHLFSRKEGARVENKTKNrYKNILPFDHTRVVLHGGDPSIVGsdYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRN
..| | .|.||.|.  .|   .|.|.|.  | |        |  ||||  .  | .   ..|| |     . .  ||.|. .. |  ||.  ..|| . .
qrllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle

KCARYWPGIN-ETGEYGDISVQNATECINPHYIYREFIIHRIEdpsNQREVFHYHFKAWPDHGVPQ--DPGTVLSFLQDI------NSKQDEL-------
|  .|.|    |  ..| . |.      .  . .| ..... .   .  .|.||..  | .  .|.  |  ..   ....      . |.. |       
ksdkyfpdktreelkfGildverkefvkrniletrllelskGn...ethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkky

VTTGNEPGPlIVHCSAGIGRTGTFIVIDILLNVMmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
. |     | |. .. |  |.|.|.|||.|.... ..  .    ..  |  |. .|   | ...|. |.|  .| .. ...
ihtppsfap.iiqsarGsaraGvfvvidllirli.dnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 252-509 5.1e-37 122.1 In-house 46-290 (305) alignment
Range on Protein: 252-509
Range on HMM: 46-290/305.0
FSRKEGARVeNKTKNRYKNILPFDHTRVVLHggDPSivGSDYINANYISGEVpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCA
|  .. | . ..|||||...   |.. | |.  .||   |||| |||.   .   || .|..|| |  ||..|| |. |.  . |||  . || |. |||
fnanqsadi.aitknryqdvpcqdqsavkld..kps..psdyihanyvgcpm.ipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

RYWPGIN-ETGE-YGDISVQNATeCINPHYIYREFIIHRIEDP---SNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelVttgnepgPLIVHC
.|||  . |  |  . | |.| .   .|     |  |  ..     ...  | | ..  ||| |||    | | .|  |   .   |       |..|||
qywpaaqgeklelksgivvenvs.gskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk...v.......pivvhc

SAGIGRTGTFIVIDILLNVMMQQGfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY-HI
||||||||| . |. .|. . ..       .   .. .| ||.  .|.. || |..| .|   .
sagigrtgtivaieyilekiaenk..pcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

0045098 (Phosphotyrosine protein) phosphatases II 253-510 4.6e-82 270.8 In-house 24-273 (278) alignment
Range on Protein: 253-510
Range on HMM: 24-273/278.0
SRKEGARVENKTKNRYKNILPFDHTRVVlhggdpsivgsDYINANYISGEvpGseKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCAR
.  .. ...|. |||||.|||.||.||.           |||||.||.|   .  |..|||||.||.|..|||.|.|.. ...||| |..||.||.|||.
eitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPGiNETGEYGDISVQNATECINPHYIYREFIIHRI---EDPSNQREVFHYHFKAWPDHGVPQDP--GTVLSFLQDINSKQDELVTTG-------NEPG
|||  ... .|||..| .  |.....|..| .... .   .    .|.|.|.|.. ||||||| .|    .|..|. |.. ...|..         ...|
ywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PLIVHCSAGIGRTGTFIVIDILLNVMmqqgfEADVDIQRAIQLVRAQRSG-MVQTEQQYKFVYRSILYHIE
| .||||||.|||||.......|  .     |  ||.. |.. .| || | .||...||.|.|. .|....
pvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPRN_pd Subfamily PTPRN 253-506 1.4e-55 183.1 In-house 47-289 (297) alignment
Range on Protein: 253-506
Range on HMM: 47-289/297.0
SRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEVPGsEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCAR
... . . .| .|||.|..||.||.|| |.  . |   ||||||  |  . |  .  |||||| |..|. |||.|.|.. . .||. |.  | | ..|.|
tkevakaeknvkknrskavlpydhsrvklke.easaeksdyinasaildhdpr.apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPGiNETGEYGDISVQNATECIN-PHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkqdelVTTGnEPGPLIVHCSAGIG
|||  . .  |.   |.  .| |    |. | | .  ..  |. | |  .|| .||..|||  . ..| | . .|         |    |..||||.| |
ywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvnk.....syrG.rscpivvhcsdGaG

RTGTFIVIDILLNVMMQqGFeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
|||..|.||..|| ... |   ..||  ... .| ||.|.|.|..|..|.. .. 
rtGvyilidlvlnrllk.Gv.keidiaatlehlrdqrpglvktkdqfefaltava

subfamily_ptpA1_pd Subfamily ptpA1 253-464 5.5e-47 155.4 In-house 38-254 (418) alignment
Range on Protein: 253-464
Range on HMM: 38-254/418.0
SRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVPgseKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCAR
   || .  | .|||| |||| .|||| |.  .    |||||||||| |  |   |..|.||| || || |||.|.|..  .|||| . | |  | || |
etsegdkkhntsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPGI---NETGEYGDISVQNATECINPH----YIYREFIIHRI--EDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVTTGNEPGPLI
|||     ..   ||.      |  ..         || | . |      . |.. .|... |||| .|.    .  .|. |  .|.... . .   |.|
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGIGRTGTFIVIDILLN
||||||.||||||    |...
vhcsagvgrtgtfctavimmk

0040439 (Phosphotyrosine protein) phosphatases II 254-509 2e-81 268.5 In-house 3-246 (249) alignment
Range on Protein: 254-509
Range on HMM: 3-246/249.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARY
.... ..||| ||||..|||.||.||.|.   |.  .||||||.||  ... . ...|||||.|| |..|||.|.|.. ...||| |..||.||.|||.|
ysvallpenkdknrypdilpydhsrvklsi.lpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPGiNETGEYGDISVQNATECINPHYIYREFIIHRIeDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELvttgNEPGPLIVHCSAGIGRT
||  ... ||||..|..  . ....|. |.. ....   .. |.| |...  |||||||... ..|.|.. ... ..||    ...||..||||||.|||
wpl.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRt

GTFIVIDILLNVMMqqgFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
||||.....|. .     | .||.. |..|.| ||.|.||...||.|.|. .|...
Gtfiaaylmleqle...kelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPN3_pd Subfamily PTPN3 254-507 6e-77 253.3 In-house 33-273 (280) alignment
Range on Protein: 254-507
Range on HMM: 33-273/280.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGGDpsivgSDYINANYISGEVPGSE--KHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCA
 ..  . || .||||..|||.|.||| |. ..     .|||||||.. |.|...  ..|||||| |..| .|||.|.|...|..||| |. ||||| || 
isaarkpenlsknryrdilpydatrvklkese.....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

RYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttGNEPGPLIVHCSAGIG
.|||  ... |||..||.   |  .  |..||..... |  ...|....  . ||||||||.|.  .|.|.. .....        .  |..||||||||
qyWPetedeleygefsvkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGig

RTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY
||| .|.... | .. .   . .| .   .. .| ||. .|||..|||||  .|| 
rtGvlilletalaliea...aepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 254-510 7.9e-77 253.0 In-house 20-269 (274) alignment
Range on Protein: 254-510
Range on HMM: 20-269/274.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISGEvPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARY
..|     ..||||||.||| ...||.|.  ...   |.||||||| |   . .| |.|||| ||.|..|||.||.||..|.|||.|.  |. ..|||.|
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPGINET---GEYGDISVQNATECINPHYIYREFIIHRIEDpsnQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvtTGNEPGPLIVHCSAGI
.|  ...   ..|||.....     . .|  |.....  |.   .|.| || . .|||| .|.|. |.|...........|   . .. .| .|||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesree...enaklapvvvhCsaGi

GRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
|||| || |.| .. . .   |  ||. . .  .| .| |||||..||....| .  . .
GrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 254-506 4.8e-45 148.4 In-house 48-280 (290) alignment
Range on Protein: 254-506
Range on HMM: 48-280/290.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgSDYINANYISGevpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARY
||   .  . .|||||..   | |||.|. | .     ||. |||. |     .  .| ||| |  |. |.|.|. ||    |||  . .| |. ||..|
rkifdkntefkknrykdvvcndktrvilkdGyd....GdyvhanyvkG....lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPGIN-ETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINskqdelvttgNEPGPLIVHCSAGIGR
.|  . |.  .|.|.|  . |  .   | .  .  |  |   .  . |.. |.|||. |..   ..|  |. .           . .||..|||||||||
ypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..........kasGpvvvhcsaGiGr

TGTFIVIDILLNVMMQqGFEadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
||||. |.. |..... | |  .|.   .. .|  | . || . ||  . . .|
tGtfvaievglqilld.Gke..ldlldlvralrnsrlnsvqvdiqylalveill

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 255-509 3.4e-59 195.4 In-house 41-284 (297) alignment
Range on Protein: 255-509
Range on HMM: 41-284/297.0
KEGARVENK---TKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYIsgevPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRnKCA
...   |.|    |.|||||||.|  || |.  . .   |||.|| ..    .| ....|.||   ..|..|||.|...|  ..||| ... || . |||
qpqtvaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfv....kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kca

RYWPGINETGeYGDISVQNATECINPHYIYREFIIHRiEDPSNQREVFHYHFKAWPDHGVPQ--DPGTVLSFLQDINSKqdelVTTGNEPgPLIVHCSAG
|||.    |  .||.||.  .      .| ||. . . ... ..| |  |.|  |||. |..  .  ..| ...... .      . .|  ||.|||.||
ryWsdkgvtt.fGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkd....fsqnaeg.PllvhclaG

IGRTGTFIVIDillNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.|||| .. ||   .|. .   | .|||   .. .| .|  .|||..||||||  .|  .
vGrtgvlltid...svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

0049772 (Phosphotyrosine protein) phosphatases II 256-518 6.8e-50 165.9 In-house 40-289 (314) alignment
Range on Protein: 256-518
Range on HMM: 40-289/314.0
EGARVENKTKNRYKNILPFDhTRVVLhgGDPSIVGSDYINANYISGEvpgseKHYIATQGCLPTTINDF----------WKMI--WQESSQIIVM-----
 .  ..|..||||..|||.| .||.|  .  .. |||||||.|..|      . .||||| |. |..||          |.|.  ..  . .|||     
vadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------TTNEVERGRNKCARYWPGINetgeygdisvqnatecinphY-------IyrefiihriedpsnQREVFHYHFKAWPDHGVPqDP
                 ..  ..|   .|.... ..                                           .|....|.   .||...| ..
ladelsrLdaAlgKtpllildgngneptaadlellk....................eelydpelf..............erlgikylripvpDgsap.ll

GTVLSFLQDINSKqdelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMmqqgfeaDVDIQRAIQLVRAQRS-----GMVQTEQQYKFVYRSILYHIE
  ...||. |..         ...||..|||.||.||||||.|...|.  .       .|... |.. ||..|.     |.... .|| |... .|....
edfdeflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

TQRQLSES
.... .|.
flkkfyey

subfamily_egg_pd Subfamily egg 256-509 4e-29 96.3 In-house 34-270 (307) alignment
Range on Protein: 256-509
Range on HMM: 34-270/307.0
EGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGsDYINANYISGEvPgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERgrNKCARYWP
. |  .|..| | | .   | .|| |.      .. |.| ||...|. |    ..| .|  |  | .|||.|..||  | ||| |  .|   ..|  |||
taasdnnlekarskrvhckdssrvklelrrGqyld.dfihanrvkGk.p.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

GI-NETGEY--GDISVQNATECINPHYIYREFIIHRIEDPsnQREVFHYHFKaWpDhgvpqdpgtvLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGR
   ...  .  | . ..|     ..  ..|   .. .     . | |  |.. . |          . .. |. |    |    |   | .|..  |. .
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwq.g.d..........vnnssdvysplrvlrklrnlskpvvvqdilGvsk

TGTFIVIDILLNVMMQqGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
..|.. |.| |  ... |      ..||....| .|   |..  .| |||| .|. .
aatlvaieiallsllr.Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

0042113 (Phosphotyrosine protein) phosphatases II 257-509 7.8e-80 263.1 In-house 4-243 (245) alignment
Range on Protein: 257-509
Range on HMM: 4-243/245.0
GARVENKTKNRYKNILPFDHTRVVLHgGDPSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG
....|||.||||..|||.|||||.|   |..  .||||||.|.   ..   ...||||| || |..|||.|.|.. ...||| |.|.|.||.|||.||| 
allpenkdknrysdilpydhtrvkls.pdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

iNETGEYGDISVQNATECINPHYIYREFIIHRiEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTF
 .|. .|||..|.. .| ....|. |.. ... .  . .|||.|||.  ||||||| .. ..|.||. ... . |     ...||..||||||.||||||
.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtf

IVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
|.....|. .   .   .|... |.. .| ||.|.|||..||.|.|. .|...
iaaylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 257-508 5.1e-67 221.4 In-house 56-291 (319) alignment
Range on Protein: 257-508
Range on HMM: 56-291/319.0
GARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTnevergRNKCARYWPG
    .|| |||. |||.||...| |.  .  . .|||||| ...|    ... |||.|| |. |..|||.|||.  .  ||. |      ..||..||| 
anldqnkdknriinilafdknvvklerli.GeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl

-INETGEYGDISVQNATECINphYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQdinsKQDELVTTGNEPGPLIVHCSAGIGRTGT
 |... | ....|.  .|. .  |. |.. . .     ..|..  .||. |||.|||. |  .. ...    |   | .  |.. ...||||||.||||.
kivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk....kvrhltskenhranivvhcsaGvGrtGv

FIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY-H
.||.|.||. | .   |  ||. . .. .| ||. .||   ||||.| ..|  |
yivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 257-315 8e-08 26.4 In-house 43-95 (95) alignment
Range on Protein: 257-315
Range on HMM: 43-95/95.0
GARVENKTKNRYKNILPFDHTRVVLHGGdpsiVGSDYINANYISGEVpgSEKHYIATQG
|.   |  |||. ||.|.| |||||         |||||| .. |      . |||.||
gsseanipknrflnifpydatrvvlttk....rdsdyinacfvdgya..rkncyiaaqg

0037934 (Phosphotyrosine protein) phosphatases II 258-508 5.3e-79 260.4 In-house 6-241 (243) alignment
Range on Protein: 258-508
Range on HMM: 6-241/243.0
ARVENKTKNRYKNILPFDHTRVVLhggDPsivgSDYINANYISGEvpgseKHYIATQGCLPTTIND----FWKMIWQESSQIIVMTTNEVERGRNKCARY
 ..||..||||..|||.||.||.|   ..    |||||||.| .      ...||||| || |..|    ||.|.|.. ...||| |..||.||.|||.|
llpenlsknrysdilpydhsrvkl...eg....sdyinanliyvt.....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPgiNETgEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVT--TGNEPGPLIVHCSAGIG
||  .|. .|||..|..  |   ..|..|.. . ... .  .|.|.|||. .|||||||..|  .|.||..... ..||..  . .. ||..||||||.|
wp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFIVIDILLNVMmqqgfeaDVDIQRAIQLVRAQRSG-MVQTEQQYKFVYRSILYH
||||.|.....|  .       .||.. |..|.|.||.| .|||..||.|.|. .|..
RtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 258-513 1.5e-70 232.3 In-house 16-268 (270) alignment
Range on Protein: 258-513
Range on HMM: 16-268/270.0
ARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI
. . .|. |||..|||  .|||.|.  .     . ||||||. | . |..|.|||..| ||||...||.|||.| .. |||||. .|.||.||.||||  
eaargkklnRyadiLPsPatRvrleeleed.sataYinAnyvrG.fdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

NET---GEYGDISVQNATECINPHYIYREFiihRIEDPSNQREVFHYHFKAWPDHGVPQDPG------TVLSFLQDINSKQDELVTTGnepgPLIVHCSA
...    |.|.|.| . .|  .  || ..    |.|. ...|.. |.....|||||||....       .|. |...   ..||  ..    ||.|||||
pkekvkledgkikvlalseekeegyiltrl...rleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae....PllvHcsa

GIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
|.|||||.|..|| .... ..     ||. . |. .| .|  .||. .||.|.|.... ..|.. 
GvgRtGtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 258-515 8e-70 229.9 In-house 5-248 (250) alignment
Range on Protein: 258-515
Range on HMM: 5-248/250.0
ARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpGSeKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNkCARYWPgI
 . .|| |||| .|...|..||||.  . .   |||||| .. |   .. | .||||| |..||.|||.|...| |. ||| || .| ... . .||| .
kkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.v

NETGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvtTgnEPGPLIVHCSAGIGRTGTFI
... .|||. |.   . .   |. |.... . .  ...| | ..|| .||| |||.   .|| .|......|..   .  . .|.||.||||.||.|.||
ekaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqq...a..gnaPvivqCsaGvgrsGafi

VIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
.|| .|.   .   |  ||. . |. .|..| ..|....|| |||. ||  ...  ..
aidavle...rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 258-519 2.9e-42 139.5 In-house 44-297 (305) alignment
Range on Protein: 258-519
Range on HMM: 44-297/305.0
ARVENKTKNRYKNILPFDHTRVVLHGGDPsivgSDYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI
   ... |||||..  .|. || |.|  |     .|| |||.|   |   | .| ||  |  |  ||| | .|.  . | |  | .|.| .||. |..  
keaqeagknrykdvgcldnnrvklegpwp....heyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

NET----GEYG-DISVQN-ATECIN---PHYIYREFIIHRIEDPSN-QREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttgnepGPLIVHCS
..      | |  |||.  ... ..   .     .  .  || | . .| | |||.  ||| |||    ..| .|..  . .          ||..||||
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..........gpivvhcs

AGIGRTGTFIVIDILLNVMMQQGFEAdvDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQLSESN
|||||||. .... .|. ...       | .. .| .| ||   .||..|| ||.. || ... .. | |. 
agigrtgsvvmleyildqllagqiie..dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeev

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 258-519 7.8e-34 111.6 In-house 48-300 (310) alignment
Range on Protein: 258-519
Range on HMM: 48-300/310.0
ARVENKTKNRYKNILPFDHTRVVLHGgDPSIVgSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI
|  ..  |||| ...  | .|| |.  | |    ||| |||.  .     . .| .|| |  || |||.||.|| .. |..  . .| || ||  ||| .
aykkymhknrysdvvcldtsrvklki.dksry.edyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl

NETGEYGDISVQNATECINPHYIYR---EFIIHR---IEDPSNQREV--FHYHFKAWPDHGVPQDPGTVLSflqdinskQdELVTTgNEPGPLIVHCSAG
  |  || | | | .|  .   |      |.       |.|.| .|.     ..  ||| |||..    .         |  |..     || .||||||
gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp........q.rllaq.vrhgpcvvhcsag

IGRTGTFIVIDILLNVMmQQGfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQLSESN
..|... . ... .. . ..|    ||..  .  .. .|   .||| || .. |  .    .... .|. 
kdrlyvvvalklkidkl.drg..lkvdaeevktellksraiciqtelqyliidrvriifargetevaeki

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 259-509 6.9e-48 158.0 In-house 30-295 (297) alignment
Range on Protein: 259-509
Range on HMM: 30-295/297.0
RVENKTKNRYKNILPFDHTRVVLHGGdpsIVGSDYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN
|     ||||..|| .| ||| | ..   | ..|||||.|.      .. .|| .|| | .|..|||......  ..||| ..  | ||.||| ||| ..
rnsslrknryrdilatddtrvkllrv...iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

ETG-EYGDISVQNATEC---INPHYIYREFIIHRiedpSNQREVFHYHFKAWPDHGVPQDPGTVLSF--------------LQDIN-------SKQDELV
. . . ||. |.  ..     .  ..    .|.|    |..| | |  | .||||||| |   .  |              |  ..        . . | 
qerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr

TTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgFEAdvDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.    . .|.||||||.||.|  .  |..|... .. .    |..  .. .| ||. .||| .|....|  .|  .
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.rip..dvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 259-511 2.6e-34 113.5 In-house 30-261 (267) alignment
Range on Protein: 259-511
Range on HMM: 30-261/267.0
RVENKTKNRYKNILPFDHTRVVLHGGDPSivgsdYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEverGRNKCARYWPG-I
  .|. .||. . ||.|.|||.|   .       |||| |. |     ....|.||. |  || ||...| ..   .||. |.    . ..  ..||  .
aeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyk..tknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkm

NETGEYGDISVQNATECINPHYIYREFIIhRIEDPSnQREVFHYHFKAWPdhgVPQDPGTVLSFLQDINSKQDelVTTGNEpgPLIVHCSAGIGRTGTFI
 .. .| |..|. . |  .  |    . . .... |  ..|  |..| |    .  .    |  |  | .|..  .  ||   ||.|.||.|.||.|||.
gqakkyqdltvehslekeendyqiitlel.kfknes.ahnvtlyyykkwn...intnnkpylkplfgilaknq..lengnr..PlvvacsdGvGrsGtfl

VIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
|||  |. . .   |  .||   .. .| || |.|.| ..| ......  . | 
vidsqlerakt...egvsdifdflrkirsqriglvdtkeryiyihellaeyaeg

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 259-509 1.8e-18 61.2 In-house 44-279 (303) alignment
Range on Protein: 259-509
Range on HMM: 44-279/303.0
RVENKTKNRYKNILPFDHTRVVLHggDpsivgSDYINANYISGEvpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN
 |.|  |||. ... .||..| |   |     | || |.|.  .   |.|. | ||  |. |  |||.|| ..  . ...   . |  .      .|  .
fvknmdknrfvdvicldhskvkls..d.....ssyihasyleld...sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

ETGEYGDISVQNAtEcINPHYIYREFIIHRIE--DPSNQREVFHYHFKAWPDHGVPQDPGTvlSFLQDINSKQDELVTTGNePGPLIVHCSAGIGRTGTF
.  .. . |..   | ..   .   . .. .   . . .  .  .|.||||   .| |      |...|   |  |    .   | .    .| ||.|||
dflkfeersirvg.e.fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysd.stptvymslsgcgragtf

IVIDILlnVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
 ...     .  .  .| .|. . .. ||  |   ||   |. .||  .  |.
alfeta..hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 260-510 8.3e-60 197.3 In-house 41-277 (515) alignment
Range on Protein: 260-510
Range on HMM: 41-277/515.0
VENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-IN
  | .|||||||||.| .|| |   . .   |||.|| || .    ..| |||.|| ......|||....||    |.| |.  |  . ||..|||    
einfkknryknilPydsvrvklevindn.Phsdyfnasyipsf..dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

ETGEYGDISVQNATECINPHYIYREFIIHRIEDpsnQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVttgnepGPLIVHCSAGIGRTGTFIV
.. ..| |.|.  .       | |.. . . .|    | |  .||. |||.|||..  ..| ..... ......        |||.|||||.|||| .| 
dsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt......hpliihcsaGvGrtGvvis

IDillNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
||   .|. .      ||. . .. .|..|  .|||..|| |.|  .| .. 
id...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 260-511 2.8e-34 113.5 In-house 41-273 (288) alignment
Range on Protein: 260-511
Range on HMM: 41-273/288.0
VENKTKNRYKNILPFDHTRVVLHgGDPSIvgsdYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-IN
..| |..||.|.   | ||| |.  ||      ||.|| .|      ... | .|  | .||. .|||. ..  . ||| .. .|.|..| | |.|  . 
ianptrdryenlprcditrvkls.ddpdf....yiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

ETGEYGDISVQNATECINPHYIYREFIIhRIEDPSNQRE-VFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvttgnepgPLIVHCSAGIGRTGTFI
|.  .| .  .   .  . . . .  .. ||. . ...  | . |.. |.|.|||..  . | .|. ..| |           |..||.|||.|||||.|
ekarigrlctvvkkkradidklvkvsll.riskegeekvivkilhlleWdddgvPenylsplrllevlkslqk..........PivvhssaGvGrtgtli

VIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
.| | |...     . .. |.. ..  |..|   .|||.|| .|.| .|...  
lilialeslrl...ddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 260-368 5.9e-31 102.4 In-house 45-160 (350) alignment
Range on Protein: 260-368
Range on HMM: 45-160/350.0
VENKTKNRYKNILPFDHTRVVLH-------GGDPSIVGSDYINANYISGEVPGSEK----HYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRN
||  .|||||||||..|.|| |.       . . |. ..|||||||.. .... |     .|||||. || |..||.|.| .   ..|.. |..|| ...
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

KCARYWPgineTGEYGDISV
|| |||.     |.| || |
kcyrYWq....egsydditv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-512 1.5e-27 91.1 In-house 41-279 (312) alignment
Range on Protein: 260-512
Range on HMM: 41-279/312.0
VENKTKNRYKNILPFDHTRVVLHGGDpSIvgsdYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINE
.  |  ||| ||  .|  |  | | .  .    || ||..   .    .....||| |  |.  ||..    .|  |.. .  || | .|||.|   |  
lkfkdlnrypniqcwdrgrftlagde.nf....yihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

TGEYGDISVQN--ATEcINPHYIYREFIIHRIE-----DPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDInsKQDElvttgnepGPLIVHCSAGIGR
  .  |  |     || |.     .. | ||.         ..  . || . .|||||.|.   | | .|  .  |.|          |.| |||||.||
fvdledhrvyteycte.ieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav..kkdk........kpviahcsagvgr

TGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
|||...|. ..  . .       ... .  |.| .|.  |..  || .. |..|  . ..
tgtlaliesmiaalrhp...rkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 260-373 4.1e-23 76.3 In-house 46-170 (349) alignment
Range on Protein: 260-373
Range on HMM: 46-170/349.0
VENKTKNRYKNILPFDHTRVVLHGG-DPSI------------VGSDYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERG
||  .|||||.|||..|.||.|. .  .|             .  |||||||..      ||.|||||  ||.|..||.|.|  .  ....  ... | .
velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

RNKCARYWPGINETGEygDISVQNATE
 .|| .||   . ..    . .||. .
lekcdiywqelsysni..tvklqnssl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 260-302 2e-08 28.0 In-house 45-86 (440) alignment
Range on Protein: 260-302
Range on HMM: 45-86/440.0
VENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGE
 .|| ||||.||| .||.||.|.    ..  |||||| ||.| 
pnnkvknryrnilaydhsrvmleevk.gvpdsdyinasyingi

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 261-508 6.9e-66 217.6 In-house 24-255 (284) alignment
Range on Protein: 261-508
Range on HMM: 24-255/284.0
ENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTnevergRNKCARYWPG-INE
.|| |||. .||.||...| |.  .  . .|||||| .|.|    ... |||||| |. |..|||.|||.  .  ||. |      ..||..|||  |..
qnkdknrighilafdknvvklerli.GeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

TGEYGDISVQNATECINphYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQdinsKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVI
. | ....|.  .|. .  |. |.. . .     ..|..  .||. |||.|||. |  .. ...    |   | .  |.. ...||||||.||||..||.
keerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvk....kvrhltskenhranivvhcsagvgrtgvyivl

DILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY-H
|.||. | .   |  ||. . .. .| ||. .||   ||||.| ..|  |
dvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 261-506 9.8e-61 200.0 In-house 2-236 (237) alignment
Range on Protein: 261-506
Range on HMM: 2-236/237.0
ENKTKNRYKNILPFDHTRVVLHGGDPSivgSDYINANYISGeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINET
||| |||| ||  .||.||||.|   .   ||||||.|. | . |. |.|||.|| | .. .|||.|.|||   .||| |  .|. . || .|||  .. 
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

GEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVID
  || ..|    .     |  | ... .     . | .. |.| .|||.||||   ..| | ..|  .   .    .| || |.|||||.|||| |.|||
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv....sesgpwiihcsagvgrtgiflvid

ILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .|    |   .  |||   .. .  .|  ..||..|| |....||
amlr...qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 261-506 1.6e-57 189.4 In-house 6-237 (239) alignment
Range on Protein: 261-506
Range on HMM: 6-237/239.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPgiNET
 ||.|||| ||. .||.||||         ||||||.|.  .  || | |||||||. ..  |||.|.|||   .||| |  .|  ..|| .|||  . |
vnkaknryanivtydhsrvvleklsnd.phsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dst

GEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINskQDELvtTGNEpgPLIVHCSAGIGRTGTFIVID
 .| .. |      .   || | |.. .. . ...| |..|||  |||.||||   .|| . . |   .| |   |    | ..|||||.||||.|.|||
skycnlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl..pgar..pwvihcsagvgrtgaflvid

ILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .|    .|     |||   .. .| .|  |||| .|| |.. ..|
amlrqakkq...ktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 261-506 1.7e-57 189.3 In-house 7-238 (239) alignment
Range on Protein: 261-506
Range on HMM: 7-238/239.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPgiNET
 ||.|||| ||. .||.||||         ||||||.|.  .  || | |||||||. ..  |||.|.|||   .||| |  .|  ..|| .|||  . |
vnkaknryanivtydhsrvvleklsnd.phsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dst

GEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINskQDELvtTGNEpgPLIVHCSAGIGRTGTFIVID
 .| .. |      .   || | |.. .. . ...| |..|||  |||.||||   .|| . . |   .| |   |    | ..|||||.||||.|.|||
skycnlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl..pgar..pwvihcsagvgrtgaflvid

ILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .|    .|     |||   .. .| .|  |||| .|| |.. ..|
amlrqakkq...ktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 261-513 1.4e-18 61.4 In-house 50-289 (302) alignment
Range on Protein: 261-513
Range on HMM: 50-289/302.0
ENKTKNRYKNILPFDHTRVVLHGGDpsivgSDYINANYIsgEVPGSEKHYIATQGCLPTT---INDFWKMIWQESSQIIVMTTNEVERGRnKCARYWPGI
.|  ||. ...   |...| |..        .|.||  .  |||  ..  | .|    ..   ...||.|..||. . .|.   | |  .     ..|  
knlkknqsedvpildsnlvkleaep.....dsyvnaskv..evPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

NE-TGEYGDISVQNATeCINPHYIYREFIIHRI-EDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDInskqDELVTTGNEpgPLIVHCSAGIGRTGT
 .   |||.. | |     . .    ...|  . |. ||   .  |... |... ||.  ...    ...     .. . ..|  ....    |.|| |.
sgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv....fakkikade..ntvivSknGaGRaga

FIVIDILLNVMmQQGfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
|..  . .. . |.|  ... |.  .. .|.||. .|.. .|| ..|...|..| .. 
fltlavavekl.qkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkv

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 261-418 1e-07 25.0 In-house 26-161 (169) alignment
Range on Protein: 261-418
Range on HMM: 26-161/169.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINAnyisgevpgsekhyiatqgclpttindfwKMIWQESSQIIVMTTNEVERGR----NKCARYWPG
 |.||||    |   |||| |.      .|||||||                             .|||.  . .||.  .  ..       .  .  | 
cnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasvivvlgdtddknnfwpekedyqlhpa

INeTGEYGDISVQNATECINPH------YIYREFIIHRIEDPSN-QREVFHYhfKAWPDHGVPQDPGTV
.   ||.   |.   |. ...        .   ..||. .|    . ...||   .||. |||| |  |
vi.lgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhy..stwpqngvpqspvhv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 261-418 3.3e-07 23.3 In-house 25-160 (169) alignment
Range on Protein: 261-418
Range on HMM: 25-160/169.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINAnyisgevpgsekhyiatqgclpttindfwKMIWQESSQIIVMTTNEVERGR----NKCARYWPG
 |.||||    |   |||| |.      .|||||||                             .|||.  . .||.  .  ..       .  .  | 
cnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasvivvlGdtddknnfwpekedyqlhpa

INeTGEYGDISVQNATECINPHYI------YREFIIHRIEDPSNQrEVFHYHFKAWPDHGVPQDPGTV
.   ||.   |.   |. ..|            ..||. .|   . ..  .|. .||. |||| |  |
vi.lGewytdslyvrtdkvhpntsgveglfevslvihsydddvte.qlsllhystwpqngvpqspvhv

Y_phosphatase Protein-tyrosine phosphatase 262-506 4.2e-82 270.5 Pfam-A 1-234 (235) alignment
Range on Protein: 262-506
Range on HMM: 1-234/235.0
NKTKNRYKNILPFDHTRVVLhggDPSIVGSDYINANYISGEVpGsEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWP-GINET
||.|||||.|||.|.||| |   . |   ||||||||..|     .|..|||||.|. ||.|||.|.||| ...||| |...|.||.|||.|||   .|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

GEYGDISVQNA-TEC-INPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttGNEPGPLIVHCSAGIGRTGTFIV
 .||||.|..   |. .. .|. |.. ..  ...|..||| ..|...|||||||..|  .|..........       .. ||..||||||.||||||..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfva

IDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
.||||. . ...    ||.  ... .|.|| ||||...||.|.|. ||
ldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 262-506 4.2e-82 270.5 In-house 1-234 (235) alignment
Range on Protein: 262-506
Range on HMM: 1-234/235.0
NKTKNRYKNILPFDHTRVVLhggDPSIVGSDYINANYISGEVpGsEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWP-GINET
||.|||||.|||.|.||| |   . |   ||||||||..|     .|..|||||.|. ||.|||.|.||| ...||| |...|.||.|||.|||   .|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

GEYGDISVQNA-TEC-INPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttGNEPGPLIVHCSAGIGRTGTFIV
 .||||.|..   |. .. .|. |.. ..  ...|..||| ..|...|||||||..|  .|..........       .. ||..||||||.||||||..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfva

IDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
.||||. . ...    ||.  ... .|.|| ||||...||.|.|. ||
ldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 262-511 3.7e-53 175.1 In-house 1-173 (182) alignment
Range on Protein: 262-511
Range on HMM: 1-173/182.0
NKTKNRYKNILPFDHTRvvlhggdpsivGSDYINANYISGEVPGSEkhYIATQGCLPTTINDFWKMIWQESSQIIVMTTnevergrnkCARYWPginetg
|..||||..|||.||.|           ..||||||.. |  |...  .||||| |. |..||..|....  ..||. |         . .|||      
nldknrysdilpydhsr...........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

eygdisvqnatecinphyiyrE-FiihriedpsnQREVFHYHFKAWPDHGVPQdPGTVLSFLQDINSkqdelvttgnEPGPLIVHCSAGIGRTGTFIVID
                     | .          .|....|..  |||||||  . ..|.|......          |.|| .||||||.|||||.....
.....................ell..........erlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaay

illnVMMQQgfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
    .|...    .|... |..||| .|.|||.|..|| |... .|.... 
....lmkkl....gvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 262-506 3.7e-31 103.1 In-house 35-267 (285) alignment
Range on Protein: 262-506
Range on HMM: 35-267/285.0
NKTKNRYKNILPFDHTRVVLHGGDpsivgSDYINANYIsgEVPGSEK-HYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-INE
|   ||| ..   . |||||.  |      ||| |...   .|| ..  ||.||| || |..|||.||.||    ..|    .| | .||| |.|  . |
npdlnryadvrcieetrvvlknhd.....rdyihaswm..rmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TGEYGDI--SVQNATECINPHYIYREFIIHRIEDPSNQ-REVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkqdelVTTgnEPGPLIVHCSAGIGRTGTF
  ..|    .. .. |      |.  . .   || |..   . | .   |||.  |.|   .. . . ..      |    .  |. ||||||.||| ||
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.....vnp..kekpicvhcsagvgrtatf

IVIDILLNVMMQQGFEADVDIQRAiqlVRAQRSGMVQTEQQYKFVYRSIL
. ||     .|..     .|| |    .|| |   ||.  |. |.|  ..
vgidyatirimenpniemldivre...mramrfqavqshmqflflyvvlm

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 262-337 3.8e-10 33.8 In-house 37-115 (347) alignment
Range on Protein: 262-337
Range on HMM: 37-115/347.0
NKTKNRYKNILPFDHTRVVLHGGDPSIVGS----DYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQE-SSQIIV
. .||| |.    | |||||   .     .     |||| .|      ..|.|| ||  || |. |||||.     .|.. 
slsknrskdvklidatrvvlspeksknsraddvetyinashik..fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 263-509 2.6e-30 100.2 In-house 51-281 (301) alignment
Range on Protein: 263-509
Range on HMM: 51-281/301.0
KTKNRYKNIlPFDH-TRV-VLHGGDpsIVgsdYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINE-
| |.||... | .  | | |.  |    |    | ||.|. .  |  ...||||| |. | .||| |. |   . ||| ...||.  .||. | |   . 
kdkhryptv.PckPstavevivdGk..rv...Pihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

T---GEYgDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLqdinskqdELVTTGNEpgPLIVHCSAGIGRTGTF
.   | . .| ..|    .| . . |.. ..   .  . | | || .. |.|.|||.    .  ..        |||   ..  |..|||||||||. .|
kldigrf.kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm........elvkksek..PivvhcsaGiGrsvaf

IVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
|  ..| . .     .  .....|.. .| .|   |||..|  ..    .| .
igteylarevea...dptieltealkhlrehrwngvqtnsqlywmtlGtvyrl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 263-518 2.5e-24 80.9 In-house 20-269 (290) alignment
Range on Protein: 263-518
Range on HMM: 20-269/290.0
KTKNRYKNILpFDHTRVVLHGGDpSIVGSDYINANYISgeVPgSEKHYIATQGCL-------PTTINDFWKMIWQESSQIIVMTTNEVERGRN----KCA
. ..|... | . .|||||.|   .   .||| ||...  .| .  . |.||  .         ||..|| |. || .. .||. .  |. .|     ||
emdqRlevpL.veatrvvLkgyg.krfnddyiHAnrvt..cp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

RYWPG-INETGEYGDISVQNATECINPHYIYREFIIHRieDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvtTgnepgPLIVHCSAGI
.| |  ..|   .....|.      .   . || ...   |  ..  | |. .| | .  |..|. |.|| .| .. ..     |     | ||||  ||
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkask.....t.....pvivHcvdGi

GRTGTFIVIDILLNVMMQQgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL-YHIETQRQLSES
 |  ..  |..    ....  . .| .. ... .| ||  ........ ||   |. . ||...| .|.
SrsAalaaiilgyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaee

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 272-363 3e-06 21.6 In-house 3-78 (130) alignment
Range on Protein: 272-363
Range on HMM: 3-78/130.0
LPFDHTRVVlhggdpsivGSDYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTnEVERGrnkcARYWPGINETGEY
|.|. .|.          | .||||...   . |  . |. ||  |  |  |||||. .    ..|.    ||        |||  .    |
lefevsrlq.........gntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpdsePlewy

0044763 (Phosphotyrosine protein) phosphatases II 273-504 5.1e-35 116.1 In-house 1-166 (178) alignment
Range on Protein: 273-504
Range on HMM: 1-166/178.0
PFDHTRVVLHGGdPSIVGSDYINANYISGEvpgsekHYIATQGClpttiNDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINEtgeygdisvqnat
|.|.|||.|.   . . .||||||..| .        |......      |........  . ||. |.|.|.|..|| .|||  ..             
pldrtrvllsnl.eglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............

ecinphyiyrefiihriedpsnqrevFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVmmqqgfe
                          ..|..  .||||||. .  .| |.. |.. .|      ...|| .||||||.||.||........         
..........................iqylhipipDhgvpdllehflefvefieeald......ekggpvlVHCsaGvgRsgtlvaaylmkkl.......

aDVDIQRAIQLVRAQRSgMVQTEQQYKFVYRS
 ..... ||.|||..|. .|... |....|. 
.glsleeaielvrerRp.ivpnpgqlrqLyef

0036282 (Phosphotyrosine protein) phosphatases II 290-502 3e-45 149.4 In-house 1-163 (174) alignment
Range on Protein: 290-502
Range on HMM: 1-163/174.0
GSDYINANYISGEVPGSekHYIATQGCLPttindFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGinetgeygdisvqnatecinphyiyrefiihri
|||||||..... .  .  ..||.||.|.     ||.|.........|| ..|.|.|. || .|||                                  
gsdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

EDPSNQREVFHYHFKAWPDHGVPQDPGtVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMqqgfEADVDIQRAIQLVRAQRS
   .  |....|..  ||||||| ..  .|.|.. ... . |     .. ||..||||||.|||||.......|  ..    |  ||. . .. .| ||.
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrp

GMVQTEQQYKFVY
|||||..||.|.|
gmvqtpsQyrfly

0043147 (Phosphotyrosine protein) phosphatases II 290-502 6.5e-44 145.0 In-house 4-154 (172) alignment
Range on Protein: 290-502
Range on HMM: 4-154/172.0
GSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEvergrnkcarywpginetgeygdisvqnatecinphyiyrefiihRI
|||||||.|... .    ...|||||.|. |..|||.|....  ..||. |..                                               
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

EDPSNQREVFHYHFKAWPDHGVPqDPGTVLSFLQDINSKQdelvtTGNEPGPLIVHCSAGIGRTGTFIVIDILLnvmmqqgfeADVDIQRAIQLVRAQRS
  .  .|....|..  ||||||| ..  .|.||. |....       .. || .||||||.|||||.......|          ..... |..|||..|.
dpellerlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRp

GMVQTEQQYKFVY
|.||...||.|.|
gavqnpsqyrfly

0046846 (Phosphotyrosine protein) phosphatases II 290-508 1e-43 144.4 In-house 11-172 (176) alignment
Range on Protein: 290-508
Range on HMM: 11-172/176.0
GSDYINANYISGEvpgsekHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGEygdisvqnatecinphyiyrefiihri
..||||||.| |       ..||||| || |. ||..|....  ...|. |.||| || ||..||| . . |                            
dldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

edpsnqrevfHYHFKAWPDHGVPQDpGTVLSFLQDINSKQDElvttGnepGPLIVHCSAGIGRTGTFIVIDillnvMMQQgfEADVDIQRAIQLVRAQRS
          .|..  |||||||..   .|..|. |.. ..|    |   || .||||||||||||.....     ...   | ..... |..|||.||.
..........qylhlpwpDhgvpdl.elllellefirealke....g...gpvlVHCsaGigRtgtlvaay.....llel..ekglsveealalvreqRp

-GMVQTEQQYKFVYRSILYH
 |.|||..||.|.|. .|..
lgavqtpeQyrflyefelll

0051429 (Phosphotyrosine protein) phosphatases II 291-511 9.4e-55 181.4 In-house 4-227 (272) alignment
Range on Protein: 291-511
Range on HMM: 4-227/272.0
SDYINANYISGEvpGS---EKHYIATQGCLPTTINDFWKMiWQESSQIIVMTTNEVERGRNKCARYWP-----------GINETGEYGDISVQNATECIN
|.||||....|   |.   .. .....|.|| |..|||.. ...    ||. ..|.||||.|| ||||              .| .||...| .  | . 
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPgtVLSFLQDINSkqdelvttgnePGPLIVHCSAGIGRTGTFIVIDILLnvmMQQGFEADVD
..||.||...... .... |||.|.|. .||||||||..  .|..|. ...           .||..||||||..||||......||   .. . |. ||
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivd

--------IQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
        ...|.. .|||| |.||||.||.|.|. .|  ...
dYlltnlyleeaveelraqrpgavqteeqylflyeallellrs

0051082 (Phosphotyrosine protein) phosphatases II 291-504 3e-37 122.8 In-house 3-148 (151) alignment
Range on Protein: 291-504
Range on HMM: 3-148/151.0
SDYINANYISGEvpgsekhYIATQGCLPttinDFWKMIWQESSQIIVMTTNEVERGrnKCARYWPGINetgeygdisvqnatecinphyiyrefiihrie
|||||..|. |        .....| |.    ||.......  . ||. ..|.|||  .|..|.|  .                                
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

dpsnqREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkqdelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLnVMmqqgfeadVDIQRAIQLVRAQRSG
     .||.|...  |||.|.|. . .||.||. ...         ...||..||||||.|||||.......|  .        |... |.. .|..| |
.....ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylml.lg........vsleealeeyrlkrpg

MVQTEQQYKFVYRS
.||..||. |... 
vvqpnqqflfqlfa

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 307-503 9.2e-28 91.8 In-house 3-197 (198) alignment
Range on Protein: 307-503
Range on HMM: 3-197/198.0
EKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN-ETGEYGDISVQNATECINPHYIYREFIIH-RIEDPSNQREVFHYHFK
...|||||  |  |. |||.|.|.  |  |||  ..        . |||  .  ||.|| .||   | . .| |    .|.      |   ||. || | 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPQDPgTVLSFLqdINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYR
.| ..  |.     . |.  . |..       .   |.||||| | | || |. .|| .    ..   . ||.    . .|  | |.. . |.|.|.|.
swkekttpnva.lfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 307-503 9.6e-28 91.7 In-house 4-198 (199) alignment
Range on Protein: 307-503
Range on HMM: 4-198/199.0
EKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN-ETGEYGDISVQNATECINPHYIYREFIIH-RIEDPSNQREVFHYHFK
...|||||  |  |. |||.|.|.  |  |||  ..        . |||  .  ||.|| .||   | . .| |    .|.      |   ||. || | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPQDPgTVLSFLqdINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYR
.| ..  |.     . |.  . |..       .   |.||||| | | || |. .|| .    ..   . ||.    . .|  | |.. . |.|.|.|.
swkekttpnva.lfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfevakrlrqarcgiisslqhynfiyq

0049260 (Phosphotyrosine protein) phosphatases II 308-502 4.6e-41 135.4 In-house 9-143 (152) alignment
Range on Protein: 308-502
Range on HMM: 9-143/152.0
KHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWpginetgeygdisvqnatecinphyiyrefiihriedpsnqrevfHYHFKAWP
...|||||..| |..|||.|...   ..||| |...|.|. ||..|.                                             .|..  ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHGVPQDPGTVLSFLQDINSKqdelvtTGNEPGPLIVHCSAGIGRTGTFIVIDILLnvmmqqgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVY
|||||...  .| .|. |.          .. || .||||||.|||||.......|          .|... |..|||..|.|.|....|..|.|
Dhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 313-508 2.6e-21 70.9 In-house 39-220 (255) alignment
Range on Protein: 313-508
Range on HMM: 39-220/255.0
TqgclptTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQnATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGV
       |.. |...| |  .. .|| ..  | |..|| .|.|   .|   . |..|  .|. ..   .    |.  . .  . ..| ||..| |...  
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt.ttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PQDPGTVLSFLQdinskqdeLVTTGnepGPLIVHCSAGIGRTGTFIVIDILLNVM---MQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYH
|...  .|  |.        .|.      ...||||.||||. .|......   |   ...   ...|  . .. .| .|.. ..|  |  |    .|  
Pelareilnilk........vvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl





subfamily_hpo-7_pd Subfamily hpo-7 317-506 8.4e-18 59.2 In-house 43-224 (263) alignment
Range on Protein: 317-506
Range on HMM: 43-224/263.0
LPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQnATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDP
|  ||. |...| |  .. .|| ..  | |..|| .|.|   .|   . ...|  .|. ..   .  . ..  ...  . ..| || .| |...  |...
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc.ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

GTVLSFLQdINSKQDelvttgnepgPLIVHCSAGIGRTGTFIVIDILLNVM---MQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
  .|  |. .. .            .|.||||.||||.  | |....   |   ...   ...|  . .. .| .|.. ..|  |  |    .|
reilnilk.varnsk..........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 319-501 9.8e-20 65.2 In-house 102-280 (302) alignment
Range on Protein: 319-501
Range on HMM: 102-280/302.0
TTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWP-GINETGEYGDISVQNA--TECINPHYIYREFIIHRIEDPS------NQREVFHYHFKAWPDH
 |.. .| .| | .  |.|  .. || . .||| |.   .... ..|  .|.     . ..     ..| .. .|          .. |   .| |||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPQDPGTVLSFLQDINSKQDElvttgnepgpLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFV
| |... | |  |.  .| . .          ..||||||.|||||.. |   ... ...      |.   .. ||. | | ||.|||  ..
Gapkeaytaldilkfcesykkn..........vlvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqdeqqliyl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 370-513 1.4e-15 51.5 In-house 195-348 (349) alignment
Range on Protein: 370-513
Range on HMM: 195-348/349.0
NATECINPHYIYREFIIHrieDPSNQREVFHYHFKAWPDHGVPQDPgtvLSFLQDINSKQD-------ELVTTGNEPGPLIVHCSAGIGRTGTFIVIDIL
|  .|..|.    . |     . ..  |..   .| |.| ..  .|    |.|| .. |.|       .|    ..  .|.|||||| ||||... .|.|
nkknCdlpddddddaill...avekPyellqlqvknwldlslllnP...isilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldll

LN--VMMQQGFEaDVD--------IQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
|.   ..|. .   ..        |. ..  .| ||  |||  .|. ..| ..| ..  ..
lsileplqnesn.kiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk

0048076 (Phosphotyrosine protein) phosphatases II 388-505 5.8e-28 92.8 In-house 37-139 (145) alignment
Range on Protein: 388-505
Range on HMM: 37-139/145.0
RIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvttgnePGPLIVHCSAGIGRTGTFIVIDILLNvmmqqgfeADVDIQRAIQLVRAQ
  | .   |....|..  |||||||... ..|.||. |.. ..|       .|| .||||||.|||||.......|          .|... |..|||.|
tselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsq

RSGMVQTEQQYKFVYRSI
|.|.|....|..|.|. .
rpgavpnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 388-503 2.3e-27 90.9 In-house 39-139 (144) alignment
Range on Protein: 388-503
Range on HMM: 39-139/144.0
RIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvttgnEPGPLIVHCSAGIGRTGTFIVIDILLnvmmqqgfEADVDIQRAIQLVRAQ
  | ..  ||...|..  |||||||...  .|.||. |.. ..       |.|| .||||||.|||||........        . ..... |..|||..
eyepefleregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsr

RSGMVQTEQQYKFVYR
|.|.|....|..|...
rpgavpnpgqlrfLle

0048567 (Phosphotyrosine protein) phosphatases II 392-500 3.4e-07 24.8 In-house 24-130 (157) alignment
Range on Protein: 392-500
Range on HMM: 24-130/157.0
PSNQREVFH-------YHFKAWPDHGvPQDPGTVLSFLQDINSKQDelvTTGNEPGPLIVHCSAGI---GRTGTFIVidilLNVMMQQGFEAdvdiQRAI
|..  ....       ...  . |.| | . ... .| . .|.. .    . .......|||.||    |||.|.|     .  .. .|| .    . ||
pkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflk...ilelagkaiavhckaglkkrgrtatLig....cYlilhlgftp....eeai

QLVRAQRSGMVQTEQQYKF
...|  | |.|   ... .
aplrivrpgsvpfrdasyl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-509 4e-22 73.2 In-house 87-194 (440) alignment
Range on Protein: 394-509
Range on HMM: 87-194/440.0
NQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvtTGNepGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQ
. | . .||...|||.|||.  | || ..||.|  |..   .||  |||.|||||| ||||  |..| .|    .     ..||   |. .| .|  |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek...agn..gpllvhcsagagrtgviiavdsilreakr...sdqidifsfinsmrnnrpqmvq

TEQQYKFVYRSILYHI
| .|| ||. ..|  .
tpeqyafvheavlegl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 394-513 6.2e-21 69.5 In-house 213-348 (350) alignment
Range on Protein: 394-513
Range on HMM: 213-348/350.0
NQREVFHYHFKAWPDHGVPQDPGTVLSFLQ----DINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLN-----VMMQQGFE-ADV------DI
.  .|.. ..| |.| ..  .|  .|. |.     |..   |.    ..  |..||||||.|||||.. .| ||.      .... ..  ||       |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

QRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
.  .. .| ||  |||. .|. |.| ..|.. . ..
siivnelrkqrismvqnldqfifiYeallfyfaLrk

subfamily_PTPDC1_pd Subfamily PTPDC1 394-507 9.3e-11 36.5 In-house 79-174 (182) alignment
Range on Protein: 394-507
Range on HMM: 79-174/182.0
NQREVFHYHFkAWPDHGVPQdPGTVLSFLQdinskqdeLVTTGNEPGPLIVHCSAGIGRTGTFIVIDILlnvmmqqgFEADVDIQRAIQLVRAQRSGMVQ
 ......| | .|.|.||.    ..|   .        .|.   . | . ||| || ||||  |   ..        .  ... ..||.|||..|.  .|
meqgiyvynf.gwkDygvas.leriLdivk........vvafalqegkvavhChaGlGrtGvliacylv........yakrltaekaiklvrskrpksiq

TEQQYKFVYRSILY
| .| ..|    |.
treqvelvkefalf

PTEN_1 394-502 1.3e-09 33.2 In-house 91-186 (196) alignment
Range on Protein: 394-502
Range on HMM: 91-186/196.0
NQREVFHYHFKaWPDHGVPQdpgtvLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTfividILLNVMMQQGFeadVDIQRAIQLVRAQR-SGMV
... | ..||  ..|||.|      ||.|.||  . .| .   .. .  .||| ||.||.||     ..   .|. |     . . |..|||..|  |..
fksgveylhfp.ieDhgaps.....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGt.....vvaayLmykgk...ltadeAlelvrekRppgap

QTEQQYKFVY
.. .| ....
nspsqerlle

0038934 (Phosphotyrosine protein) phosphatases II 396-504 8.7e-14 47.1 In-house 77-172 (194) alignment
Range on Protein: 396-504
Range on HMM: 77-172/194.0
REVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDIllnvMMQQGFeadvDIQRAIQLVRAQRSGMVQTE
.  ..|.   .||.|.. .  ..|.||. .. . .|     ...|   ||| ||.|||||...  .    .. .|.    . . ||.|.|  | |.... 
kagieylklpfpddgtvPsleillrfldlvdeflne.....dpggvvaVHCkaGlgRtGtlvaaYL....iyrlgm....saeeAialfrekRpgaipnq

QQYKFVYRS
.... ... 
dyleallkr

PTPc_DSPc_SM00012 398-507 1.9e-33 110.2 In-house 2-105 (105) alignment
Range on Protein: 398-507
Range on HMM: 2-105/105.0
VFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVTtgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeADVDIQRAIQLVRAQRSGMVQTEQQ
| |||...|||||||...  .|..|....... .  .     .|..||||||.||||||...||||. ....     |||.. .. .| ||.||||||.|
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeq

YKFVYRSILY
| |.|| .|.
ylflyralle

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 401-514 1.3e-06 22.2 In-house 232-343 (347) alignment
Range on Protein: 401-514
Range on HMM: 232-343/347.0
YHFKAWPDHGVPQDPGTVLSFLQD-INSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqGFEADVDiqRAIQLVRAQRSGMVQTEQQYK
|   .|| .  |.|   ||....  ..     |..  .   |..| |  |. |. | ..  |... ... |   |.|    .. .| ||.|.      | 
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvld.gktpdcd..dlfkkmrdqragvftmsifyt

FVYRSILYHIETQRQ
.  |. |...  . |
yairaalfylklklq

DSPc Dual specificity phosphatase, catalytic domain 410-497 1.4e-06 23.2 Pfam-A 44-123 (133) alignment
Range on Protein: 410-497
Range on HMM: 44-123/133.0
GVPQDPGTVLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDIllnvMMQQGFeadvDIQRAIQLVRAQRSGMVQTEQQ
..|..  |   . .....  . . .  .. .  .||| ||| |..|.|.  .    |.....    ... |...|. .|| .......
ripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl....mktknl....slneAyefvkerrskispnagf

DSPc Dual specificity phosphatase, catalytic domain 410-497 1.4e-06 23.2 In-house 44-123 (133) alignment
Range on Protein: 410-497
Range on HMM: 44-123/133.0
GVPQDPGTVLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDIllnvMMQQGFeadvDIQRAIQLVRAQRSGMVQTEQQ
..|..  |   . .....  . . .  .. .  .||| ||| |..|.|.  .    |.....    ... |...|. .|| .......
ripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl....mktknl....slneAyefvkerrskispnagf

PTPc_motif_SM00404 412-495 9.5e-07 23.8 In-house 53-128 (140) alignment
Range on Protein: 412-495
Range on HMM: 53-128/140.0
PQDPGTVLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIdillNVMMQQGfeadVDIQRAIQLVRAQRSGMVQTE
|.|  ..  .......  | . .  .. |  .||| ||. |..|.|.      .|....    .... |...|. .|. . ...
plddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia....Ylmryrq....lslaeayefvkerRpiispnl

subfamily_CG42327_pd Subfamily CG42327 425-505 2.1e-16 54.5 In-house 233-311 (319) alignment
Range on Protein: 425-505
Range on HMM: 233-311/319.0
INSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSI
||..      | .. |||.|||| |.||||. |  || .. . .   .  ||| . .. || .|.  |.| .||.|.|. .
ingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_CDC14_pd Subfamily CDC14 437-498 1.7e-07 25.4 In-house 261-314 (328) alignment
Range on Protein: 437-498
Range on HMM: 261-314/328.0
NEPGPLIVHCSAGIGRTGTFIVIdillNVMMQQGFEAdvdiQRAIQLVRAQRSGMVQTEQQY
.  | ..||| ||.|||||.|       .| . .| |    . ||  .|  | |.| . || 
kaeGaiavhCkaGLGrtGtLiac....ylmkhyrfta....aeaiawlricrPGsvigpqqk

subfamily_DSP23_pd Subfamily DSP23 442-503 8.2e-06 20.5 In-house 87-140 (148) alignment
Range on Protein: 442-503
Range on HMM: 87-140/148.0
LIVHCSAGIGRTGTFIVIDIllnvMMQQGFEAdvdiQRAIQLVRAQRSGMVQTEQQYKFVYR
. |||  | |||||..   .    . .... |      ||  || .| | |.| .| | |. 
vsvhcllgrgrtgtmlacyl....vkerklaa....aeaiaevrrlrpgsvetveqeklvrd

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 443-504 8e-11 36.2 In-house 2-60 (69) alignment
Range on Protein: 443-504
Range on HMM: 2-60/69.0
IVHCSAGIGRTGTFIVIDIllnVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRS
.||||.| ||||||| | .    | .   |  |||   .| .|  |  ||  |..| |.. .
vvhcssgtgrtgtfiaimv...emarikseklvdifnnvqymrkcrpmmvmneieyifihda

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 443-504 1.1e-10 35.7 In-house 1-59 (69) alignment
Range on Protein: 443-504
Range on HMM: 1-59/69.0
IVHCSAGIGRTGTFIVIDIllnVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRS
.||||.| ||||||| | .    | .   |  |||   .| .|  |  ||  | .| |.. .
vvhcssGtGrtGtfiaimv...emarikseklvdifnnvqymrkcrpmmvmneneymfihda