Gene PTPN9 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN9
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP059_AA protein Get Run
AqueP059_AA_731-1019 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CRAL_TRIO CRAL/TRIO domain 66-198 1.5e-12 36.0 Pfam-A 11-156 (159) alignment 
Range on Protein: 66-198
Range on HMM: 11-156/159.0
QGARDNDGAQILLFTVKKHKGGESK--TAVQLLFLLLDQISESNGT--MTKGVTLLVDLQECPQTVCD---MKYVTTIFNILNGGYPLYLNMVYILEAPS
   ||..|  .|.. .....  ...  . |.||.|.|... ... .     |||...|..       .   ....  | .||.  ||  |. ..|. ||.
ihgrDkngrpvlylrlgrfdpkklseeelvrllllvlerllklleedgqiegvtvviDmkglslskmlwkpisllkkilkilqdnyperlgkilivnaPk

WFKMSREPVYQSLSKA--GKVKMLSLI----DLSSVMSPSSLPTNL
.||.  . |.. |...   |.|..|      .|.... |..|| .|
lfkvafklvkpfldektreKikfvspsntpatlekyidpeqlpkel
subfamily_PTPN9_pd Subfamily PTPN9 731-1022 8.9e-148 486.1 In-house 2-295 (297) alignment 
Range on Protein: 731-1022
Range on HMM: 2-295/297.0
SASELEAYVNEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDY
. .||.|||.|||.||||.||..|.||||.|......|..|..||||.||.|||.|||.|......| ||||.||...||...|..| ||||||.||.|.
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDA
|||.||.||.||||.|..||...|||.||||.. ...|.|||.|||.|....| .|..|.....  |..|.|...|.|||.|||||||.......|||..
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

ARSMQGCFSEYVTDPDRFPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYLKA
.|..|........|.......|||.|.||||||||.|||..||.|...|.....|.|.|.|.|||.||||||||.|||.|||..||||||.|||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelka
0040438 (Phosphotyrosine protein) phosphatases II 732-1018 9.3e-89 293.1 In-house 5-277 (317) alignment 
Range on Protein: 732-1018
Range on HMM: 5-277/317.0
ASELEAYVNEKGIRGLSEEYFKIKNEPVTgKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYW
  ..  ... .. ..|.||.... . ..    ....||.|  ||||.|...||..|| |....  ..||||.|.| .|..... .|.|||||. ||.|.|
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAA
||.||  | |||| |...|. . |||||||.  ... ..||..| ... .... .. |..  .  ...|.|...|....||||.|||.. ....| |.|.
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

RSMQgcfseyvtdpdRfpLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
|. .           .   .| |...|||||.||.|||. ...... |. ...|.|.|.|. ||.||. ..|| ||| |.|. .||| .
real...........e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 732-1016 6.8e-67 220.8 In-house 14-289 (298) alignment 
Range on Protein: 732-1016
Range on HMM: 14-289/298.0
ASELEAYVNEKGIRGLSEEYFKIKNEPV---TGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVN
 ..|.|  ..|.. |...|. ....      . . .  | | |  |||| |.| .||.|| |... . | |||| | . ..|.. .  |.||.||..||.
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFLGWPDYGVPENGSDVIDVL
|.|||..|... .||| |. .|. |.|. .||||  .  ...|.|.||. .. . . .  |..     |. ..|.. . .|  ||| ||||| . |.|.|
dFWrmvteedigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldll

DAARSMQGCFSEYvtdpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
.  | .|    .             |....||||.||||||  .|  .. ..  ..| | . |. ||..|. ..|| |||.|.|. |||.
rkvrasqqqagnk............pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 732-1020 4.9e-45 148.6 In-house 6-239 (392) alignment 
Range on Protein: 732-1020
Range on HMM: 6-239/392.0
ASELEAYVNEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYW
.... |.|...    |  | |.   .|   .    . . |  |||||... |||.|| |. | |.  |||. | | ....  |  | .|||   ...|.|
vaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfw

RMLWEKEVFVIVMATKCVEMRklkcaqywpdglntvaqfgdisvsvvndvvegayqfrqfvayKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARS
||.....|  |.| ||  |                                            |  ..|    ..|  ||| .||.  | .. ..   ..
rmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

MQGCFSEyvtdpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
  | ..              |..||||||.||.|   |.|  .   . |  |.| . |  .|..| . .||.||||| | .|||  |. 
dfGqyth.............pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwr
subfamily_PTPN6_pd Subfamily PTPN6 733-1017 5.8e-68 224.1 In-house 14-297 (306) alignment 
Range on Protein: 733-1017
Range on HMM: 14-297/306.0
SELEAYVNEKGIRGLSEEYFKIKNEPV--TGKADYFRLPCNSTKNRYKDVICYDSTRVTLNsIPDTEGSDYIHANYCNGYQ--KPKGIILTQGPLKRTVN
||||   ....  |..||. ....| .  . . .  . | | .||||| .. .| |||.|.  |.. ||||| ||| .. .  . |  | ||| |. ||.
selekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvs

DYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAqFGDISVSVVNDVVEGAYQFRQFVAY---KNGETRHLMHYQFLGWPDYGVPENGSDVIDV
|.|||.|...  ||||.|| ||  | |||.||||  .. . .|.|||. |..    .|..|...     |..|.|....|.|  ||| |||.. . |.| 
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

LDAARSMQGCFSeyvtDPdrfplHGPPMVIHCSAGIGRSGTFASLDYCIDELR---MTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
|.  .. |  ..    .      .  |.|.|||||||| |||  .|  .. ..   .  ....|..|...|.||   .||..|| | ||.. .| 
ledvnrkqeele....ea.....eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 734-1020 7.8e-67 220.3 In-house 7-280 (315) alignment 
Range on Protein: 734-1020
Range on HMM: 7-280/315.0
ELEAYVNEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRM
.. |.||..    |  | |.   .| . .    | . | .|||||... .||.|| |. | |.  |||| | | ..... |  | .||||| .|.|.|||
qfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrm

LWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQ
.....|  ||| ||  |  |.||.|||||     ..|| |.|....    .    |..|  |  |.| .  .|| .||| ||... | .. .. . .. .
vlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadn

GcfseyvtdPDRFplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
|        .. |     ....|||||.||.| . |.| ...... |. |.| . |. ||..| . .||.|.||| | .|||. |. 
g........kkef.....sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
0051299 (Phosphotyrosine protein) phosphatases II 735-1017 1.5e-91 302.1 In-house 10-286 (288) alignment 
Range on Protein: 735-1017
Range on HMM: 10-286/288.0
LEAYVN---EKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYW
|. .|.    .|. || ||. .. .  ....  ...||.| .||||.|...||..|| |..... ||||||.|.| .||....  |.|||||. ||.|.|
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

RMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAY------KNGETRHLMHYQFLGWPDYGVPENGSDVIDV
||.||..| |||| ||.||. . |||||||.  ... ..|||.|  .. .|.. |  |..         ..||.|. .|.....|||.|||.. ....| 
rmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldf

LDAARSMQGcfseyvtdpdrfpLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
| ..|...               .|.|.|.|||||.||.|||. ||.... |. ...|.| | |. ||.|| ...|| ||| |.|...|||.
lrlvrkala.............sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 736-1020 3.2e-92 304.4 In-house 33-302 (308) alignment 
Range on Protein: 736-1020
Range on HMM: 33-302/308.0
EAYVNEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLnsipdTEGSDYIHANYCNGY--QKPKGIILTQGPLKRTVNDYWRM
... . ... .|.||.... . .. .. ....||.| .||||||...||..|| |      ||||||.|.| .||   .|. .|.|||||. ||.|.|||
kllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrm

LWEKEVFVIVMATKCVEMRKLKCAQYWPDGLN-TVAQFGDISVSVVNDVVEGAYQFRQFVAYK--NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAAR
.|| .| |||| ||.||. . |||||||. |. .. ..|...| ...  |.. |  |..   .  .||.|...|.....|||.|||.. ....| |...|
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

SMQgcfseyvtdPDrfplhgPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
...         |.      .|.|.|||||.||.|||. ||.... |.....|.|.|.|. ||.||....|| ||| |.|...|||....
ksl.........pg......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 738-1021 2.3e-36 120.3 In-house 12-275 (288) alignment 
Range on Protein: 738-1021
Range on HMM: 12-275/288.0
YVNEKGIRGLSEEYFKIKNEPVTGKADYFRlpCNSTKNRYKDVICYDSTRVTLNsipdTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEK
.| . .. ||  ||    ||     .| |    |.|..||... . | ||| |.     .   ||.||     . .. .| .| ||. |.. .|.|| |.
lvlqiaveglkkeyrdspneasidiidsfi..anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmlles

EVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVN--DVVEGAYQFRQFVAYKNGETRH-LMHYQFLGWPDYGVPENGSDVIDVLDAARSMQg
.|  ||| .. .|  | | |.|.|  |   |..| .   | .  . ..   .   .   |.||..  . .  .| |.| |||||    . .|.  .|.| 
dveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq.

cfseyvtDpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYLK
                 |.|.|.|||.||.||..     .. ||... . ... .  ||..|  .|||  || . .. |||. |. |
.......k.........PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 738-810 1.8e-07 24.9 In-house 14-86 (440) alignment 
Range on Protein: 738-810
Range on HMM: 14-86/440.0
YV-NEKGIRGLSEEYfKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGY
|| |..  |   .|.  .    ..  .|   || |  ||||.....|| .|| |. .     |||| | | || 
yvqnnrrsrafedew.sllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
0039614 (Phosphotyrosine protein) phosphatases II 739-1019 4.5e-86 284.2 In-house 26-291 (297) alignment 
Range on Protein: 739-1019
Range on HMM: 26-291/297.0
VNEKGIRGLSEEYFKIKNEPVTgkADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDT-EGSDYIHANYCNGYQK-PKGIILTQGPLKRTVNDYWRMLWE
 . ... .| .|...... ..     ...||.| .||||||...||..|| |...... ..||||.|.| .|| . .. .|.|||||. ||.|.|||.||
ekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

KEVFVIVMATKCVEMRKlKCAQYWPDGLNtvaQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCF
  | |||| ||.||. . |||||||.  .   ..||..| ...  ... |  |..   .|||.|...|.|..||||.|||.. ......|...|. .   
qgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

seyvtdpdrfpLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
             | |...|||||.||.|||. ...... |. . .|.|.|.|. ||.||  ..||..|| |.|. .||. ..
...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 739-1016 3.7e-84 277.8 In-house 14-276 (278) alignment 
Range on Protein: 739-1016
Range on HMM: 14-276/278.0
VNEKGIRGLSEEYFKIKNEPVtGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKE
.. .. ..|..|.... . .. .  ....||.| .||||||...||..|| |....  ..||||.|.| .||..|...|.|||||. ||.|.|||.||  
lllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

VFVIVMATKCVEMRKLKCAQYWPdglNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcf
| .||| |..||. . |||||||   ... ..||..| ...  ... |  |..     ..||.|. .||..|||||.||||. |...| | |.|...   
vttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal...

seyvtdpdrfPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
          .  . |...|||||.||.|||. |..... |. . .|...|.|. ||.||. ..||..|| |.|. .|||
..........edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 739-1017 4e-52 171.7 In-house 21-283 (290) alignment 
Range on Protein: 739-1017
Range on HMM: 21-283/290.0
VNEKGIRGLSEEYFKiKNEPV--TGKAD--YFRLPCNSTKNRYKDVICYDSTRVTLNsipDTEGSDYIHANYCNGYQKPkgIILTQGPLKRTVNDYWRML
| .|.. .|. ||.. |  |   ..  .   |    . .|||||||.| | ||| |.   |    ||.|||| .| . .  .|||||.|| || |.|||.
vvkknvdelakeyle.klkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmv

WEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFV---AYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARS
 ...| .|||  . .|  | ||.||.|.    |  ||.|.|   ..  . |   .. .     ..|    | |..   |||  |.     .. .| . | 
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk

MQGcfseyvtdpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
. |                 |.|.||||||||.|||.... ... |    .... . || ||. |. |.| | ||    . .|.. 
asG.................pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
0036941 (Phosphotyrosine protein) phosphatases II 740-1019 5.2e-88 290.4 In-house 8-279 (297) alignment 
Range on Protein: 740-1019
Range on HMM: 8-279/297.0
NEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLnsipDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
. ... .|..|. .. .  . |. ....||.| .||||||...||.||| |    | ||||||.|.| .||. .. .|.|||||. ||.|.|||.||  |
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

FVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVV--EGAYQFRQFVAYK--NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGC
 |||| |..||. . |||||||.  . . ..||..| ...  |  .. |  |..  ..  |||.|...|....||||.||||. ....| ....|...  
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

FseyvtdpdrfpLHGPPMVIHCSAGIGRSGTFASLDYCIDELR---MTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
.             |.|...|||||.||||||. .|.... |.   ....|.. |.|. ||.||....|| ||| |.| ..||. ..
l...........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0047943 (Phosphotyrosine protein) phosphatases II 740-1017 1.2e-87 289.2 In-house 7-272 (273) alignment 
Range on Protein: 740-1017
Range on HMM: 7-272/273.0
NEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLnsipDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
. .|...| ||. .... .. ..  ...||.| .||||||...||..|| |    . .|||||.|.| .||.... .|.|||||. ||.|.|||.||. |
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

FVIVMATKCVEMRKLKCAQYWPDGLNT-VAQFGDISVSVVNDVVEGAYQFRQFVAYK--NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCF
 |||| |..||. . |||||||.  .. . ..|...| ...  ... |  |..  ..  .||.|. .|....||||.|||.. ..... ....|...  .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

SEYvtdpdrfplhgPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
 .            .|.|.|||||.||.|||. ||...| |.....|.| |.|.|||.||  ..|| ||| |.|...|||.
psn...........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 740-1016 1.3e-84 279.9 In-house 22-303 (307) alignment 
Range on Protein: 740-1016
Range on HMM: 22-303/307.0
NEKGIRGLSEEYFKIKNEPV--TGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDT-EGSDYIHANYC--------NGYQKPKGIILTQGPLKRTVN
  ... || .|. |.... |   |. ....||.| .||||||...||.||| |.|.... |.||||.|.|         .|| ... .|.|||||. ||.
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

DYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGlNTVAQFGDISVSVVNDVVEGAYQFRQFVAY---KNGETRHLMHYQFLGWPDYGVPENGSDVIDV
|.||||||. | |||| |..||. . ||||||||  ... ..|.. | ...  ... |. |..      ..||.|...|....||||.|||.. ....| 
dFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

LDAARSMQGCfseyvtdpdrfpL-HGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNK---VNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
....|....             |  | |...|||||.||.|||. ...... |. ...   |...|.|.|||.||  ..|. ||| |.|. .||.
ieevrkalee............lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 740-1017 4.4e-75 247.7 In-house 15-280 (318) alignment 
Range on Protein: 740-1017
Range on HMM: 15-280/318.0
NEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
.|.|   ||||| ... .. |  .     |.| .|||| ... ||.||| |. . ..|||||| ||| .||.. |  | .|.|| .|..|.|||.||.. 
resGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqns

FVIVMATKCVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNG--ETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfs
 |||| |...|  | |...|||.  .   ..|.. | . ..|  . |  |.|   ...  |.|.   |..  ||| ||||.|....|..  ....|    
avivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq....

eyvTDPDRfplhgPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
   .....      |.|.|||||.|| |.|  .|  .. ..  . |.| . |. ||.||   .||..|| |.|...||. 
...qksga.....gpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 740-1017 1.5e-71 236.1 In-house 18-283 (319) alignment 
Range on Protein: 740-1017
Range on HMM: 18-283/319.0
NEKGIRGLSEEYFKIKnEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
...| ..| .|. ..| |.|. . |    . |..||||.... || |||.| .....|||||| |.. .|||. .  | ||.||. |..|.|||.||.|.
astgetllekefkllk.eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

FVIVMATKCVEMRKLKCAQYWPDGlnTVAQFGDISVSVVNDVVEGAYQFRQFV-AYKNGET--RHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcf
...|| || ||  |.|. .|||.   .. ..| . | . ..     |  |..    |..|   |...|.|.. ||| .|||..  ..|.|   |  .   
sivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr...

SEyvtdpdrfPLHGpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
..        . .| |.|.|||||.|| |||  ||  .. ..  . ..| . |. || || . .|. ||| |.|...||..
ek........tqsg.PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 740-1016 6.2e-71 233.8 In-house 10-275 (281) alignment 
Range on Protein: 740-1016
Range on HMM: 10-275/281.0
NEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
...  .|. ||| |...  |   |   . . | .||||.... || |||...   ... .||| ||...||...|. | ||||.  .....|.|.||..|
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

FVIVMATKCVEMRKLKCAQYWPDGLNtVAQFGDISVSVVNDVVEGAYQFRQFVA-YKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSE
 .||| |. .|  |||| .||||. .   ..||. |. ..   .  |  |.|    ..||||.. . ... ||| |||.. .....  .. ....   ..
saivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

yvtdpdrfplhgPPMVIHCSAGIGRSGTFASLDYCIDEL-RMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
             |.|||||||.||.||. .||  .... .......|.. |. ||..| . .||  ||.| ||.||..
............aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 740-1018 2.1e-41 136.6 In-house 17-288 (305) alignment 
Range on Protein: 740-1018
Range on HMM: 17-288/305.0
NEKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSipdTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
 ||| .|| .|.  .|      |   |.   .. ||||||| | |  || |..   .   .||||||     .|| .| || ||..|  |.| | ... |
lekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkv

FVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVN-DVVEGAYQFRQFVA-----------YKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLD
  | |  . .|    ||..|..   . | .| .    ..      ....||.  .              ...|.  || .  ||| |||     ....| 
eaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle

AARSMQGcfseyvtdpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQ-ECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
 ||. .|                 |.|.||||||||.|.   |.| .|.|   ....     .. .|.||  |||||.|| | .. .|.| .
karpskg.................pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 741-1015 3.2e-72 238.0 In-house 17-277 (288) alignment 
Range on Protein: 741-1015
Range on HMM: 17-277/288.0
EKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVF
 ..  |.|||| .. .   | . .  ||. | .||||.... || .|| |.  ....|.||| |.| .|..| |  | |||||  ||||.|.. .|... 
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

VIVMATKCVEMRKLKCAQYWPDGlNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFseyv
 ||| |. ||  | || .||||. ..  ..|.. | .|..  .. .  |..   |... ... .||.|.||| ||||.  .....|.     .       
tivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad....

tdpdrfplhGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
           |...|||||.||.||| .||  ||... .....| . |  ||.|||. .|| .|| |.|...|.
.........tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Ptp69D_pd Subfamily Ptp69D 741-1019 5e-69 227.8 In-house 16-288 (307) alignment 
Range on Protein: 741-1019
Range on HMM: 16-288/307.0
EKG--IRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKE
 |.    || .|| |.... .  ..       |  ||||.|.. .|.||| |. |. .| |||| |.. .||.. |  |  |.|.  |..|.|||..|.|
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

VFVIVMATKCVEMRKLKCAQYWPDGlnTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNG-------ETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARS
| .||| ..  |. . |||.|||.   .  |.||| | .|.    . |  |..   |..       ..|... |...||.|. |||    ...... .|.
vtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

MQGCFseyvtdpdrfplhGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
..                  |.|.||||| ||||.| .||  ...|.  .||.. | |. ||.|| . .|  ||| |.|. .|.|  |
lykln.............rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 741-1017 1.6e-54 179.8 In-house 16-283 (290) alignment 
Range on Protein: 741-1017
Range on HMM: 16-283/290.0
EKGIRGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEG--SDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKE
 || .|  ... ....     .. .   . |...||..... ||  |.||. |.. .    .||.| | .||.. |  |.||||...|. |.|...|...
akgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

VFVIVMATKCVEMRKLKCAQYWPDGlNTVAqFGDISVSVVNDVVEGAYQFRQFVAYKN---GETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgc
| .||| |. .|. | || |||||  .| | .| .|. ..|. .   |  |..   ..   |.......||.  |.. |  .| . .. |.      |  
vtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq..

fseyvtdpdRFPLhGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
         | .    ..|.|||...|||..| ...  |.  ...  ..| . .. .|.|.  |.|| .|| . .. ||.| 
.........rkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 741-1019 1.2e-49 164.0 In-house 12-279 (307) alignment 
Range on Protein: 741-1019
Range on HMM: 12-279/307.0
EKGIRGLSEEYFKIKNE-PVTGKADYFRlpCNSTKNRYKDVICYDSTRVTLNSipDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEV
.||.. | .|. .. .  | .  .. |.  .|. ||||.|| | | .|. ..   |   ||||||||     ||| .| .||||. |. ..| |  ...|
dkgvqalvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekv

FVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGD--ISVSVVNDVVEGAYQFRQFVAY------KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARS
  ..|  |..|. |.|| ||||        ||.   ..|| |  ..      ...          ...| . |.|.  ||| |||.     |..|.| | 
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry

MQgcfseyvtDpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIDEL-RMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
 .        .         |.|.|||||.|||||  .. .  | . .  |  .... |. ||.|| ..|||. || . .. .||| | 
dt........n.........pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 741-1016 1.6e-31 104.0 In-house 23-289 (310) alignment 
Range on Protein: 741-1016
Range on HMM: 23-289/310.0
EKGIRGLSEEYFKIKNEPVTgKADYFRLPCNSTKNRYKDVICYDSTRVTLNsIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVF
  || ||  .| |.  .  .    |     .  |||| ||.| |..|| |. |  .   ||||||| .     . .| .||||. |. |.|||....   
klgieglvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

VIVMATKCVEMRKLKCAQYWPDgLNTVAQFGDISVSVVNDVVEG---AYQFRQFVAY--------KNGETRHLMHYQFLGWPDYGVPENGSDVIDvldaa
 |..  | .|  . ||  |||  |     .| | |. ...  |          ||           | .   .   ..  ||| |||..    .      
silllckvgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.....

rsmQGCFSEyVtdpdRfplHGPpMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
   |  ... |    |   |||  |.|||||..| .. ..|.. || |.  .||...| .  |...||  |||. || .  .  . .
...qrllaq.v....r...hgp.cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_PTPRG_pd Subfamily PTPRG 742-1016 1.9e-65 216.1 In-house 16-286 (563) alignment 
Range on Protein: 742-1016
Range on HMM: 16-286/563.0
KGIRGLSEEYFKIKNEPVTG--KADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGS-DYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKE
.|  |.|||. ....| ..   .|.  . |.|  |||| ... ||..||.|...|..... ||| ||| .|||| |  | |||||| |..|.|||.||..
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

VFVIVMATKCVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAYK----NGE----TRHLMHYQFLGWPDYGVPENGSDVIDVLDAAr
| .||| |. ||  . || .|||   ... ..| ..|  ..  |   |. |..|  .    ...     .. ..|..  ||| ||||    |.     . 
vaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.

smqgcfseyvtdPDRFPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
                . .  |.|.|||||.||.||.  ||  . ...  |.||| . .. .| || | .|| ||| | ....|| 
............saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_PTPRD_pd Subfamily PTPRD 745-1017 6.9e-90 297.3 In-house 23-281 (564) alignment 
Range on Protein: 745-1017
Range on HMM: 23-281/564.0
RGLSEEYFKIKNEpVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVM
  ..||| ||...  . . .  . |.|  ||||.... ||..|| |.... .|||||| |....||.|.|  | |||||..|..|.|||.||... .|||
lkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVm

ATKCVEMRKLKCAQYWPDGlNtVAQFGDISVSVVNDVVEGAYQFRQFVA--YKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGcfseyvtd
 ||..|. | ||..|||.  .  ...|.. |.... .    |..|.|     |. |.|   ...|  ||| ||||.. ...|...  |...         
ltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne........

pdrfpLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
      .  |.|.|||||.||.|||  .|.... ..  ..|.. ..|..||.|| . .|| |||.|.....||. 
.....pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_PTPRB_pd Subfamily PTPRB 745-1016 8.6e-78 256.3 In-house 25-284 (293) alignment 
Range on Protein: 745-1016
Range on HMM: 25-284/293.0
RGLSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVM
 ..|||| ..|.   . . .  .|..|..||||.... || .|| |... |..||||| ||| .||. |.  | |||||  ||.|.|||.|||.. .|||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

ATKCVEMRKLKCAQYWPDGLNTVaQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtdpd
 |..|| .| || .|||.  ..| ..|||.|..|.. .   .  |..   |. |.|....|.|. |||.||||. . ..| . . |...           
ltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai...........

RFPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
.   .  |.|.|||||.||.||| .||  ..... .. |..   |  ||..|.. .|| .|| | ...||..
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 745-1018 4.3e-66 217.8 In-house 5-269 (274) alignment 
Range on Protein: 745-1018
Range on HMM: 5-269/274.0
RGLSEEYFKIknePVTGKADYFRLPCNSTKNRYKDVICYDSTRVTL-NSIPDTEGSDYIHANYCNGYQ-KPKGIILTQGPLKRTVNDYWRMLWEKEVFVI
. | .|....   |.  . .  ... ..||||||...  . .||.| .. .. | |.|| |||  ||. . |  . |||||  ||.|.|||....|| ||
kdlekeflel...PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMATKCVEMRKLKCAQYWPDGLNT--VAQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAArsmqgcfseyV
|| ||  |... |||.|.||  ..    ..||... |.. | .  |. |..|  .  ..|...|| .  |||  .|.. . ..|...             
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev..........e

TDPDRFPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
.. ..   .  |.|.|||||||| | | . . .. .|| ...|.| . |  ||..|   .||.||| . .... .|. 
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 745-1019 1.1e-62 207.2 In-house 34-293 (319) alignment 
Range on Protein: 745-1019
Range on HMM: 34-293/319.0
RGLSEEYFKIKNEPVTGKA-DYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIV
. |  |. .. . .| .   ..  |. |  |||. ... .| ..| |. .   |.|||| | . .|||...  | .||||. |..|.|||.|| ..  ||
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MATkcvemrKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEgaYQFRQFVAYK---NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSeyv
. |      | ||.||||   .   . ....|..|..  |  |  |..   .   . . |..  . ||||||.|||. .||.. ...  | ..       
llt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken...

tdpdrfplHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
        |  ..|.|||||.||.|..  ||  .| ..  ..|.| . || |||||   .|   || |.| ..||  |.
........hranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 745-1016 1.4e-62 206.6 In-house 22-282 (305) alignment 
Range on Protein: 745-1016
Range on HMM: 22-282/305.0
RGLSEEYFKIKNEpvTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVM
.|| ..| .. .|    . |  .   | .|||.|... .|  |. |.  .... |||| |.| .||.. |  |..||||| ||.|.||...|  | .|||
kgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivm

ATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYK---NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyVT
 || ||  | || ||||.  . . .||..|| . .      |  |.. . .   . |.| ...||.  ||| |||.  . ......  .  |        
ltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq......kk

DpdrfplHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
|      .| |...|||||.||.|.| ..|  .. |.  . |.| | .. ||..|   .|| .|| |..  . |.
d......kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
0046845 (Phosphotyrosine protein) phosphatases II 746-1020 4.8e-89 293.8 In-house 1-277 (284) alignment 
Range on Protein: 746-1020
Range on HMM: 1-277/284.0
GLSEEYFKIKNEPVTG--KADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDT-EGSDYIHANYCNGY-----QKPKGIILTQGPLKRTVNDYWRMLWEK
|| ||. .. .  |.   . ....||.| .||||||...||..|| |.|.... |.||||.|.| .||      ..| .|.|||||. ||.|.|||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

EVFVIVMATKCVEMRKLKCAQYWPDGlNTVAQFGDISVSVVNDVVEGAYQFRQFVAYK---NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQG
.| |||| |..||. . |||||||.  ..| ..||..| ...  |.. |  | .   .   .||.|...|.....|||.|||.. .|... |...|... 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

CfseyvtdpdrfPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTN---KVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
               |.|.|.|||||.||.|||. ||.... |. ..   .|.|.|.|. ||.|| ...|| ||| |.|...|||....
n...........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 747-1017 3.3e-82 271.1 In-house 2-262 (263) alignment 
Range on Protein: 747-1017
Range on HMM: 2-262/263.0
LSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMAT
|.||. |....  . . .  . . |..|||||....||.||| |......||||||.||| .|..|.| .|.|||||. ||.|.||| ||..| .||| |
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEG-AYQFRQFVAYKNG--ETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFseyvtdp
...|  | ||..|||.  ..  .||.||| .|.   .   .. |..   |.|  ||| . .||. .||| |||.. ..|...| |... .          
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

drfplhGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
       .|.|.|||||.||.|||...|.....|....||...|.|. ||.||. ..||.|||.|.|...|||.
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 747-1017 3.3e-82 271.1 In-house 2-262 (263) alignment 
Range on Protein: 747-1017
Range on HMM: 2-262/263.0
LSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMAT
|.||. |....  . . .  . . |..|||||....||.||| |......||||||.||| .|..|.| .|.|||||. ||.|.||| ||..| .||| |
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEG-AYQFRQFVAYKNG--ETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFseyvtdp
...|  | ||..|||.  ..  .||.||| .|.   .   .. |..   |.|  ||| . .||. .||| |||.. ..|...| |... .          
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

drfplhGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
       .|.|.|||||.||.|||...|.....|....||...|.|. ||.||. ..||.|||.|.|...|||.
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045098 (Phosphotyrosine protein) phosphatases II 747-1019 1e-74 246.7 In-house 9-274 (278) alignment 
Range on Protein: 747-1019
Range on HMM: 9-274/278.0
LSEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTlnsipdtegsDYIHANYCNGYqkPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMAT
|. |.. .   .  ..  .. ...|  ||||||...||..||           |||.|.| .||  ||  |.|||||. ||.|.||||||  . ||||.|
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

KCVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAY------KNGETRHLMHYQFLGWPDYGVPENG--SDVIDVLDAARSMQGCFSE
..||. . |||||||.  . . ..||..| ...  | . |  | .  .      ...|.|.. |...|.|||.|||..   . ....|.  |. .  . .
elvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

YVTDPDRFPLHGPPMVIHCSAGIGRSGTFASLDYCIDELrmTNKVNVQECVRLLRQQRAF-SIQTDEQYAFCYKTVLEYALY
...   ..  .| |...|||||.||.||.. ...... |   ..|...|.|. ||.|| . ..|. ||| |.|. .||. |.
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRA_pd Subfamily PTPRA 748-1022 5.3e-69 227.6 In-house 35-300 (330) alignment 
Range on Protein: 748-1022
Range on HMM: 35-300/330.0
SEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATK
 ||.  .   |. .  .      |  |||. ... || .|| |. .  .| |||| | . .||.. .  | .|||...||.|.|||.||..   ||| |.
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte

CVEMRKLKCAQYWPDglNTVAQFGDISVSVVNDVVEGAYQFRQFVAY------KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvt
  | .. ||||||||  . .  .|.| |.| ...|  .|  |.|.        .. ..| .  . | .||| ||| ..  ....| . ....        
lkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln........

dpdrfPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYLKA
     . .. |.|.|||||.||.|||  ||  .. ..  .||.| | |. ||.||.  .|||||| |.||..||| ||  .
.....qqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 748-1021 4.5e-46 151.8 In-house 14-273 (281) alignment 
Range on Protein: 748-1021
Range on HMM: 14-273/281.0
SEEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNS-IPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMAT
 .|. ..  .| .  .  |  | |  |||| .. | | .|| |.  .|. . .|||||||       .| |||||| | |  |.|||.|...   |||  
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

KCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvTdpdrf
. .|  . |||.|.|     . ||  .|||  .  |. .    ..    .|||| . |. .  |||. |||    .. .|   |.         |     
qfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.......t.....

plhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNK-VNVQECVRLLR-QQRAFSIQTDEQYAFCYKTVLEYALYLK
     | |||||||.|||||. ... ... ..      .... |  ||   || |.|| .|| . .| .|.. .  |
.....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_PTPN14_pd Subfamily PTPN14 749-1016 1.9e-54 179.7 In-house 27-295 (300) alignment 
Range on Protein: 749-1016
Range on HMM: 27-295/300.0
EEYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTeGSDYIHANYCNGY--QKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMAT
 || .|...   .. .  .|| |  |||.|||. |. .|| |..  ..  ..|| |   .     | .  | .||||. ||.|.|.|.||..| .||| |
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KCVEMRKLKCAQYWPDG--LNTVAQFGDISVSVVNDVVEGAYQFRQ--FVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSEYVTD
.  |  | |. .|.|.    .  ..||   |.       ...  ..  .     .| | ..| |.  ||| ||||. .. .. |.  .|..  ... |  
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

pDRfplHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
      . ||...|||||.||.|     |  |  |   ....... .. ||.|| . .||  || | ||....|
.ke...skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPN13_pd Subfamily PTPN13 750-1015 5.2e-58 191.5 In-house 16-267 (273) alignment 
Range on Protein: 750-1015
Range on HMM: 16-267/273.0
EYFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNsipdTEGSdYIHANYCNGY--QKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATK
|. ....   . ...  .   | .||||..|. || |||.|.     ||. || |.. .    ..    |..||||  ||.|.|.|.||... ||.| |.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

CVEMRKLKCAQYWPDGLNTVAQFGD-ISVSVVNDVVEGAYQFRQFV--AYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtDpD
 .|  |.|| .|||.  |   .  . . |.... .   ... |..     . ||.|...| .|  |||.||| .  ... ..   |..|        . |
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq........t.d

RFplhgpPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
.      |.|.|||||||||||. ..|  .. .   ....|.| || ||.||   .||..|| |.||..||
ag.....PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 751-1020 2.1e-61 202.9 In-house 4-258 (284) alignment 
Range on Protein: 751-1020
Range on HMM: 4-258/284.0
YFKIKNEPVTGK-ADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATkcv
. .. . .| |    .  |. |  |||. ... .| ..| |. .   |.|||| | . .|||...  | |||||. |..|.|||.|| ..  ||. |   
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...

emrKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEgaYQFRQFVAYK---NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSeyvtdpdrf
   | ||.||||   .   . ....|..|..  |  |  |..   .   . . |..  . ||||||.|||. .||.. ...  | ..             
...kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken.........

plHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
  |  ..|.|||||.||.|..  ||  .| ..  ..|.| . || |||||   .|   || |.| ..||  |. 
..hranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN1_pd Subfamily PTPN1 751-1021 4.8e-56 184.6 In-house 12-275 (290) alignment 
Range on Protein: 751-1021
Range on HMM: 12-275/290.0
YFKIKNEPVTGKADYFRLPCNSTKNRYKDVICYDSTRVTLNSipdtEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVE
| .|..|    ..   .|| | ..|||.||  || .|..|..    .  ||| |.  .  .  .  ||||||| .||. .|.|.||..   .||  |.||
yldirkeasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

MRKLKCAQYWPDGLN-TVAQFG--DISVSVVNDVVEGAYQFRQFV--AYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSmQGCFSEYvtdpdr
 ...||||||| | .    ..    ..| ...  ..  |. |..     |  |||...|. .. |||.||||  .  .. |   |.  |..|.       
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre.sGslssd......

fplHGpPMVIHCSAGIGRSGTFASLDYCIDELRMTNK---VNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYLK
   .| | ||||||||||||||. .| |. ..  ...   |.... .  ||..|   ||| .|  | | ..|| |  .|
...vG.pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_PTPRN_pd Subfamily PTPRN 755-1015 3.2e-39 129.4 In-house 42-290 (297) alignment 
Range on Protein: 755-1015
Range on HMM: 42-290/297.0
KNEPVTGKAdyFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQ-KPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRK
..|| | ..   . . | .|||.|.|. || .||.|..  ..| |||| |      . .    | |||||  || |.|.|.||. | |||. |.  |   
eaepstkev..akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv

LKCAQYWPDGLNTVAQFGDISVsVVNDVVEGAYQFRQFV--AYKNGETRHLMHYQFLGWPDYGVPENGSDvidVLDAARSMQGCFSEyvtdpdRfplhGP
 .|..||||  . | .. .. . | . .    |  | |     .. ||| .  . || ||. ||| .      .|.  | .. ..        |      
kqckrywpdeGsevyhiyevhl.vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaks...llefrrkvnksyrG......r....sc

PMVIHCSAGIGRSGTFASLDYCIDEL-RMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|.|.|||.| ||.|..  .|  .. | .  .....   .  ||.||.  ..| .|. |....| |
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_CG42327_pd Subfamily CG42327 762-933 7.2e-28 92.2 In-house 20-194 (319) alignment 
Range on Protein: 762-933
Range on HMM: 20-194/319.0
KADyfRLPC-NSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQK-PKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQY
.||   .|     |.|. .|.    |||.|..|.| . . |..|.|  ||.. |   | .| .|. .  |.||..||.   ||| .|.  |    .||.|
rad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaey

WP--DGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFlGWPDYGVPENGSDVIDVLDAARSMQ
.|  ..|.    .||| |.. .  |.  |    ..    .. |.|.| || .  |.. .|| . . .| .|  .||  
lPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
subfamily_PTPRK_pd Subfamily PTPRK 763-1019 1.4e-62 206.3 In-house 35-279 (314) alignment 
Range on Protein: 763-1019
Range on HMM: 35-279/314.0
ADYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPD
 |  .   | .|||..|.. || .||.| .| .   |||| |.. ..|..|.  | |||||. ||.|.||......   ||| |. ||  ..|| .|||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

glNTVAqFGDISVSVVNDVVEGAYQFRQFVAYK----NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCfseyvtdpdrfplHGPPMVIHCS
  .|   .||| | .|.  ..  .  | |  .|      |.| . ..|||||||..|| .   .....    ..|               .  ..|.|||
..dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.............eaGrivvhCs

AGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
|| ||.|||  .|  .| ..  . |.| ..|. ||...   ..| ||| |.|  .|| .| 
aGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 763-855 3e-07 24.2 In-house 26-117 (332) alignment 
Range on Protein: 763-855
Range on HMM: 26-117/332.0
ADYFRLPCNSTKNRYKDVICYDSTRVTLNsiPDTEGSDYIHANYCNGYQKPKGIILTQGPLKR-TVNDYWRMLWEKEVFVIVMATKCVEMRKLK
  | ..  |   ||   . |.| .|| |   |.    |.  |.. .|| |    |..| |..  |   .|||. |..  .|..     | .| |
ntydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
0040439 (Phosphotyrosine protein) phosphatases II 764-1016 1.3e-77 256.1 In-house 4-245 (249) alignment 
Range on Protein: 764-1016
Range on HMM: 4-245/249.0
DYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDg
....||.|  ||||.|...||..|| |...|. ..||||.|.| .||. .. .|.|||||. ||.|.||||||  . ||||.|..||. . |||||||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

lNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFseyvtdpdrfpLHGPPMVIHCSAGI
 ... ..||..| ...  |.. |  |..  .  ..||.|. .|.|...|||.|||.. .|..| ..|.|...                | |...|||||.
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...........pkggpvlVHCsaGv

GRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
||.|||. ...... |. ...|...|.|.|||.||  ..|..||| |.|. .||.
gRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 764-1016 3.6e-76 251.1 In-house 2-242 (245) alignment 
Range on Protein: 764-1016
Range on HMM: 2-242/245.0
DYFRLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDg
....||.| .||||.|...||.||| |....  ..||||.|.| .||. ....|.|||||. ||.|.||||||  . .||| |...|. . |||||||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

lNTVAQFGDISVSVVNDVVEGAYQFRQFVAY--KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCfseyvtdpdrfpLHGPPMVIHCSAGI
 ... ..||..| ...  ... |  |..     ...|.|. .||..|.|||.|||.. ....|.|...|. .                . |...|||||.
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae............dsngpvlVHCsaGv

GRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
||.|||. ...... |. . .|...|.|. ||.||  ..||..|| |.|. .||.
gRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 764-1021 1e-43 145.6 In-house 39-284 (314) alignment 
Range on Protein: 764-1021
Range on HMM: 39-284/314.0
DYFRLPCNSTKNRYKDVICYDsTRVTLnSIPDTEGSDYIHANYCNGYqkpKGIILTQGPLKRTVNDY----------WRML--WEKEVFVIVM-------
  ..|..| .||||.|....| .|| | .  . .|||||.|.| .|.   .  | |||||. ||.|.          |||   ..  | .|||       
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------ATKCVEMRklkcaqywpdG------LNTVAqfgdisvsvvndvvegayqfrQ-------FvaykngeTRHLMHYQFLGWPDYGVPe
               ... .            .      | .                       .       |       .|. ..|  . .||...| 
delsrLdaAlgKtpllildgng..........neptaadlellk.....................eelydpelf.......erlgikylripvpDgsap.

NGSDVIDVLDAARSMqGcfseyvtdpdrfplHGPPMVIHCSAGIGRSGTFASLDYCIDELrmtnKVNVQECVRLLRQQRA-----FSIQTDEQYAFCYKT
  .|. ..|.. ..                  | | ..||.||.||.|||. ..|..  |    .|...|... .|..|       .|.. ||| |... 
lledfdeflefieea.d..............kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilea

VLEYALYLK
.|||  .||
lleylkflk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 764-1017 6e-30 99.2 In-house 28-270 (285) alignment 
Range on Protein: 764-1017
Range on HMM: 28-270/285.0
DYFRLPCNSTKNRYKDVICYDSTRVTLNSipdtEGSDYIHANYCNGYQKPK-GIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPD
 |    .|   ||| || | . ||| |.        |||||..     | .   | |||||  |..|.|.|......  ..|    .|    ||| |.|.
tytayeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

GLNTVAQFGDISVSVVN---DVVEGAYQFRQFVAYK---NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMqgcfseyvtDPdrfplHGPPMVIH
 |  | .||   ... .   . . |.      |      . |  .. | |   |||   ||.   .|..    . .         .|     .  |...|
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.........np.....kekpicvh

CSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
||||.||. ||  .||.   .    .... . || .|  |  ..|.  |. | |  ..|| 
csagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0037934 (Phosphotyrosine protein) phosphatases II 765-1016 4.3e-71 234.6 In-house 4-241 (243) alignment 
Range on Protein: 765-1016
Range on HMM: 4-241/243.0
YFRLPCNSTKNRYKDVICYDSTRVTLnsipdtEGSDYIHANYCNGYqkpKGIILTQGPLKRTVND----YWRMLWEKEVFVIVMATKCVEMRKLKCAQYW
...||.| .||||.|...|| .|| |      ||||||.||.....   ...|.|||||. ||.|    .||||||  . |||| |..||. ..||||||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdglNTVaQFGDISVSVVNDVVEGAYQFRQFVAYK---NGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSeyvtdPDRFPLHGPPMVIHC
|   ..| ..||..| ...  . . |  | .. .    ...||. .||..|.|||.|||.. .|..| ||..|. .  .      . .   .| |...||
p...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell.....sllaldsggpvlVHC

SAGIGRSGTFASLDYCIDELrmtnKVNVQECVRLLRQQRAF-SIQTDEQYAFCYKTVLEY
|||.||.||.. ...... |    .|...|.|.|||.|| . ..|| .|| |.|. .||.
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN3_pd Subfamily PTPN3 765-1015 7.3e-64 210.4 In-house 35-273 (280) alignment 
Range on Protein: 765-1015
Range on HMM: 35-273/280.0
YFRLPCNSTKNRYKDVICYDSTRVTLNSipdTEGsDYIHANYCNGYQKPKGI----ILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYW
  |.| | .||||.|.. ||.|||.|..   .|  ||| ||| |     .|.    | |||||..|..|.|.|.||... .||| |  ||  . || |||
aarkpenlsknryrdilpydatrvklke...set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDgLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNG--ETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtdpdrfPLHGPPMVIHCS
|.  .   ..|..|| . ..  . .| .|..|  ..   | |.... |.| ||| |||.. .|......  |...               .  |.|.|||
Pe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.............sgkeePvvvhCs

AGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|||||.| .  |. ..  . ....|.. . || .|.|||  .|| .|| |  ...|.
aGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 767-1017 3.9e-52 172.4 In-house 44-288 (325) alignment 
Range on Protein: 767-1017
Range on HMM: 44-288/325.0
RLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRML--WEkeVFVIVMaTKCVEMRKLKCAQYWPDGL
 .| |  |||.|.|. .| .|| |..  |   |||| |.| . ..| .  . .| ||  |.|| ||..  |.    |.|. .  ..  | .||.|||. .
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvv.lneldlgkdrcavywpkem

NTVAQFGDISVSVVNDVVEGAYQFRQF--VAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCfseyVTDPDRfplHGPPMVIHCSAGIG
    .|| . |...       |  |..     |.|||| .  .|. .|.| ||..  . .| .|.    .. .    ||   .      |...|||||.|
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser....vtantk...astpilvhcsaGvG

RSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
|.|.|.||   ....    .|.. . |. ||..|   ..| .|| ..|... |. 
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 767-1015 2.8e-48 159.3 In-house 29-293 (297) alignment 
Range on Protein: 767-1015
Range on HMM: 29-293/297.0
RLPCNSTKNRYKDVICYDSTRVTLNSIPdtEGSDYIHANYCNGYQKPK--GIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGL
. .    ||||.|.. .|.||| |   .   ..||| |.|    ....    ||.||||..||.|.|....|..| |||| .|  |  . ||| |||.  
krnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

NTVAQFGDISVSVVNDVVEGaYQ---FRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDV-------LDAARSMQGCFS---E-YVTDPDRFPLHG
.   . ||. |  . .. .  ..   . ..  .   |.|.. | |||.|||.||| .  |.            |   | .         .   . .  . 
qerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

P---PMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|   ....|||||.||||     |  .. ||     .|.  .. ||.|||  .|| ||. ..|. ||.
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 767-846 4e-07 23.1 In-house 23-75 (169) alignment 
Range on Protein: 767-846
Range on HMM: 23-75/169.0
RLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHAnycngyqkpkgiiltqgplkrtvndywRMLWEKEVFVIVMAT
 | || ||||    ..   ||| |. . .  ||||| |                           ||.|| .  |||.  
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 767-846 4.9e-07 22.7 In-house 22-74 (169) alignment 
Range on Protein: 767-846
Range on HMM: 22-74/169.0
RLPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHAnycngyqkpkgiiltqgplkrtvndywRMLWEKEVFVIVMAT
 | || ||||    ..   ||| |. . .  ||||| |                           ||.|| .  |||.  
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlG
subfamily_PTPN12_pd Subfamily PTPN12 768-1016 1.9e-69 228.7 In-house 37-276 (290) alignment 
Range on Protein: 768-1016
Range on HMM: 37-276/290.0
LPCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTV
 . | .||||||.. || .||.|. | ..|||||| ||. .| ....  | .|||| .|..|.|||.|||.| ..||| . ||. | ||..|||.  .. 
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

AQFGDISVSVVN-DVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGcfseyvtdpdrfpLHGPPMVIHCSAGIGRSGT
 .||...|.. . . |.  .  |.. . ...|.|..  ...  ||| |||.. ..........|..|               .  |.|.|||||.|| ||
lefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.............sedaPlvvhCsaGvGrtGt

FASLDYCIDELRMT---NKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
  ..||  . |.     ....| . |. ||.|||  .|| ||| . ||.|.|.
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 768-811 4.7e-08 27.0 In-house 36-78 (244) alignment 
Range on Protein: 768-811
Range on HMM: 36-78/244.0
LPCNSTKNRYKDVICYDSTRVTLNSIpDTEGSDYIHANYCNGYQ
| .|.||||| ... .| ||| |.|    |||||| ||| .| |
lsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 769-1019 2.2e-63 209.1 In-house 41-278 (515) alignment 
Range on Protein: 769-1019
Range on HMM: 41-278/515.0
PCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVA
  | .|||||... |||.|| |. | |   |||. | | ....  |  | .|||.| .|.|.||......|  |.| ||  |  | ||..||||      
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

QFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSeYvtdpdrfplhgpPMVIHCSAGIGRSGTFA
.|| |.|..|     .    |..   |. ..| .  ..| .||| |||.. | .. .. . .. .| .. .            |..||||||.|| | . 
kfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.h............pliihcsaGvGrtGvvi

SLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
|.| .. . . |. |.| . |. .||.| . .||.||||| | .|||. |.
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 769-1017 9.2e-60 196.9 In-house 7-242 (250) alignment 
Range on Protein: 769-1017
Range on HMM: 7-242/250.0
PCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLkCAQYWPdgLNTVA
| |  |||| |.| .||.|| |..    . |||| | . .||.. |  | |||||..|..|.|||..|... .||| |. .|. |  . ||||   ..  
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..vekae

QFGDISVSVVNDVVEGAYQFRQFVAYKNGETRH--LMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfsEYVtdpdrfplHGPPMVIHCSAGIGRSGT
..||. ||. .. . . |. |...  |. .. .  . ...|. ||| ||||.   |...|.  .. |    ...        .  |....||||.||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasq....qqa........gnaPvivqCsaGvgrsGa

FASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
|  .|  .. |.  ..|.| . .. ||..|  .... ||| |.|. .|.. 
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 769-1016 1.1e-52 173.9 In-house 47-278 (315) alignment 
Range on Protein: 769-1016
Range on HMM: 47-278/315.0
PCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGlntVA
  |  |||| ..| || .|| |  .   ..|||. ||. .||.|..  | .|||.  .|.|.||...|...  ||| |. ||  | |. .||||      
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv

QFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLdaaRSMQGCFSEYVtdpdrfplhgPPMVIHCSAGIGRSGTFA
 .| |.|. ... |.  |  | .    . . |... ...  ||| |||.    ....    | ..    . |           ..|.|||||.||.||| 
iyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnli...rtvkqhhtnsv..........gaivvhcsaGvGrtGtfi

SLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
.||  .|.. . | ..| . .. .||.|   .|. ||| | |...|| 
tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 769-1016 5.9e-41 135.1 In-house 38-292 (301) alignment 
Range on Protein: 769-1016
Range on HMM: 38-292/301.0
PCNSTKNRYKDVICYDSTRVTLNSIPD--TEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNT
  |.. ||.|..  ||  |..|.  |.  .   .|| |.| .||.. |  | .|||.|.|. |.||..|.. .  ||| |.  | .| || ||||.. ..
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

VAQFGDISVSVVNDVVEGAYQFRQ-----------------FVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtdpdrFPLH
  .|| ..| .||. |   .  ||                 |   .. ...... .|   ||. ||  .   |. |.|     |                
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrq............qkig

GPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
| |.|.|||....|||.. |..  ..  .    |.| . .. .|...   ..| ||| . |. . .|
ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_ptpA1_pd Subfamily ptpA1 769-969 2.6e-39 130.1 In-house 45-248 (418) alignment 
Range on Protein: 769-969
Range on HMM: 45-248/418.0
PCNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYqKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGL----
  |..|||| ...  . ||| |. | | |||||| ||| .|   || .| |||||  |. |.|||.||. . .||| ..  |  ..|| .|||. .    
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

-----NTVAQFGDISVSVVNDVVEG--AYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfSEYVTDPDRfplhGPPMVIHC
     |    ||  || .|. . .       |.     .|||| . .||. ||||. .|.    . ..| .    |    . .   ||      |...||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq...nqiipssdr....nvpiivhc

SAGIGRSGTFAS
|||.||.|||..
sagvgrtgtfct
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 770-1018 6.3e-56 184.7 In-house 50-285 (297) alignment 
Range on Protein: 770-1018
Range on HMM: 50-285/297.0
CNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKpkGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKlKCAQYWPDglNTVAQ
 |  |.|||... ||| ||.|... |   |||. | . .|...   .| || | | ||.|.|.|.....| .||| ..  |  | |||.||.|  ..|..
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd..kgvtt

FGDISVSVVNDVVEGAYQFRQFVAYKNG-ETRH-LMHYQFLGWPDYGVPENgsdvidvlDAARSMQGCFSEYVTDPDRFpLHGpPMVIHCSAGIGRSGTF
|||.|| .        .  |...  |.   .|. .  |||. |||  |...        | |.|..   ||   | .    .| |...||.||.|| | .
fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverk........dsassllklisevrkdfsqn.aeg.PllvhclaGvGrtgvl

ASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
 ..| .. | . ...|.. . |. |||.| . .||.|||.| |..|||. |
ltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPN23_pd Subfamily PTPN23 770-1017 3.7e-55 181.8 In-house 42-280 (288) alignment 
Range on Protein: 770-1017
Range on HMM: 42-280/288.0
CNSTKNRYKDVICYDSTRVTLNsipdTEGSDYIHANYCNGYQK-PKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVA
..|.|||..|.. ||..||.|.     .  ||| | . ..       .| ||.||. |.||.|.|..|. . |||| ..  |. | |...|||   .   
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

QFGDISVSVVNDVVEGAYQFRQFVA--YKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSEYVTDpdrfplhgpPMVIHCSAGIGRSGT
.|||.||.. .    . .  |..     .. ......| |.  ||..|||.  ......||...|.     . .           |.|.|||||.||.|.
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.........PlvvhCsaGvgRtgv

FASLDYCIDELRMTNKV-NVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
|| .   . ||.  | . .. . |. ||.|| |..|. ||. |.|. |||.|
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 770-1017 5.6e-47 155.1 In-house 46-278 (287) alignment 
Range on Protein: 770-1017
Range on HMM: 46-278/287.0
CNSTKNRYKDVICYDSTRVTLNsipdTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNtvAQ
 |  |||..... .|  || |.     |  ||| | . .||.. |  |....|. .|. ..|.......| .||| ..  |  . .| ||||.. .    
qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vv

FGDISVSVVNDVVEGAYQFRQFVA---YKNGETRHLMHYQFLGWPDYG-VPENGSdVIDVLDAArsmqgcfseYVTdpDRFPLHGpPMVIHCSAGIGRSG
.|. .....|. |.  |  |..      |.|...... ||.  |.. | |.|  . .. |..           | |  .| . .. ..|.|||...|||.
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt.illvieem.........ykt..qrkrgnt.sivvhCsdtvGrsa

TFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
.| . .  |.. .    ..| . ..  |.|.  |.|| ||| | .. |||| 
mfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 770-1015 3.2e-45 149.2 In-house 7-239 (239) alignment 
Range on Protein: 770-1015
Range on HMM: 7-239/239.0
CNSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQ-KPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglnTVA
 | .|||| ... || .|| |. . .   |||| |.|   |.  ||  | ||| .. .  |.|||.|..   |||| |  .| .| || |||||   . .
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...sts

QFGDISVSVVNDVVEGAYQFRQFVAYKNGET--RHLMHYQFLGWPDYGVPENGSDVIDVldaARSmqgcfseyVTDpDRFPLhGPPMVIHCSAGIGRSGT
.. .. |.. .  |   |  | ||  . |.|  |.. .|.|  ||| |||.  . |. .    |         .|  | .|    | |||||||.||.|.
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl...rrk........itk.dslpg.arpwvihcsagvgrtga

FASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|  .|  . . .  . |.. . |. .|..| . .|| ||| | . .|||
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 770-1018 1.4e-23 78.0 In-house 46-280 (303) alignment 
Range on Protein: 770-1018
Range on HMM: 46-280/303.0
CNSTKNRYKDVICYDSTRVTLNsipDtegSDYIHANYCNgYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNtVAQ
 |  |||. |||| | ..| |    |   | ||||.| .  .  |  |||| ||  |  |.|.|. |. | ....     |. ||     .|   .   .
knmdknrfvdvicldhskvkls...d...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flk

FGDISVSVV--NDVVEGAYQFRQFVAYKNGETRHLMHY-QFLGWPDYGVPENGSDviDVLDAARSMQGCFSEYVTdpdrfplhGPPMVIHCSAGIGRSGT
| . |. |   . |  |     . ..  ||. . ..|  ..  ||   .| .||    ..     .|  .  |          . | |    .| ||.||
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysd........stptvymslsgcgragt

FASLDYCIDELRM-TNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
|| .. .   |    . ...  |.  .|. |  ..|   |... |  . |. |
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 770-1017 8e-21 68.7 In-house 50-285 (302) alignment 
Range on Protein: 770-1017
Range on HMM: 50-285/302.0
CNSTKNRYKDVICYDSTRVTLNSIPDtegsDYIHANYCNGYQKPKGIILTQGPLKRTV---NDYWRMLWEKEVFVIVMATKCVEMRKlKCAQYWPDGLNT
 |. ||. .|| ..||..| |.  ||    .|..|   .  .  . |||.| | . ..   ...||| .....  .|.. .  |. |    ...|   ..
knlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

VAQFGDISVSV--VNDVVEGAYQFRQFVAYKNG-ETRHLMHYQFLGWPDYGVPENGSDVIdvldaaRSMQGCFSEYVTDPDrfplhgpPMVIHCSAGIGR
  ..|.. | .  |. ..| ....   |  ..  ..   . | .  |..  ||.. ...|      ..... | . .   .       ..||    |.||
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli......ktaakvfakkikade.......ntvivSknGaGR

SGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
 |.| .|   ...|   ...|..| |. .|.||. .... .||.. | ..| | 
agafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 770-821 1.2e-06 22.6 In-house 47-95 (95) alignment 
Range on Protein: 770-821
Range on HMM: 47-95/95.0
CNSTKNRYKDVICYDSTRVTLNSIPDtegSDYIHANYCNGYQKPKGIILTQG
.|  |||. ... ||.|||.| .  |   |||| | . .|| . .  | .||
anipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
Y_phosphatase Protein-tyrosine phosphatase 771-1015 1.4e-76 252.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 771-1015
Range on HMM: 1-235/235.0
NSTKNRYKDVICYDSTRVTLnsiPDTEG-SDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQ
|..||||||...||.||| |    ..|| ||||.||| .||...| .|.|||||| |..|.|||.|...| |||| |...|. . |||||||.  ..  .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDISVSVV-NDV-VEGAYQFRQFVAYKNGET---RHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtdpdrfPLHGPPMVIHCSAGIGRS
.|||.| .. .    | .|..|..   |..|    |....... .|||.||||. ....|.... .. .               .  |.|.|||||.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRt

GTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|||..||.....|. ...|.| ..|. ||.||. ..|. |||.|.||..||
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 771-1015 1.4e-76 252.4 In-house 1-235 (235) alignment 
Range on Protein: 771-1015
Range on HMM: 1-235/235.0
NSTKNRYKDVICYDSTRVTLnsiPDTEG-SDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQ
|..||||||...||.||| |    ..|| ||||.||| .||...| .|.|||||| |..|.|||.|...| |||| |...|. . |||||||.  ..  .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDISVSVV-NDV-VEGAYQFRQFVAYKNGET---RHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtdpdrfPLHGPPMVIHCSAGIGRS
.|||.| .. .    | .|..|..   |..|    |....... .|||.||||. ....|.... .. .               .  |.|.|||||.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRt

GTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|||..||.....|. ...|.| ..|. ||.||. ..|. |||.|.||..||
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 771-1020 3.5e-61 201.6 In-house 20-267 (270) alignment 
Range on Protein: 771-1020
Range on HMM: 20-267/270.0
NSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQ-KPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNT--V
... |||.|..    |||.|... ... . || ||| .|.. ..|  | ..|||. |....|||.||..|  |||.|. .|  . ||..|||   ..   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

AQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDvldaARSMQGCFSEYVTDPDRFPLHGpPMVIHCSAGIGRSGTF
 ..|.|.| ..... |  | ...    ..||.|.|.|...  ||| |||..  ....    ....  .. .     ...   . |...|||||.||.||.
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedssls....tdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtl

ASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
  ||...  | .|.||.| . .. ||..|   .|. |||.| ||.|.||| ..
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 771-1019 9.8e-51 167.5 In-house 48-281 (439) alignment 
Range on Protein: 771-1019
Range on HMM: 48-281/439.0
NSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKlkcaqYWPDGLNTVaqF
. ||||||||  .| |||||. ||    | || ||| .|| ..|  | |||| | |..|.||...|| .  ||| |. ||  |     |||   ...  .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevc..y

GDISVSVVNDVVEGAYQFRQFVAYKNGE----TRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtDPDRFplhGpPMVIHCSAGIGRSGT
|||.| |  ..    |  | |  ... .     | ....... |||  || . | |.| | |  | .        | . .   | |.|.|||||.||.||
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan........dkeey...g.pvvvhcsagvGrtGt

FASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
  .|| ....|.. |||...  |..||.||   .|.  || | |..|||   |
iialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy
subfamily_CG7180_pd Subfamily CG7180 771-1019 4.3e-50 165.0 In-house 42-292 (296) alignment 
Range on Protein: 771-1019
Range on HMM: 42-292/296.0
NSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKlKCAQYWPDGLntVAQF
|  |||. .|. || .|| |...   | |||| | | ... |.|  | |..| |.||...||.....|.  .|. ||  ...| .. .|||      .|.
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqy

GDISVSVVNDVVEGAYQFRQFVAYKN------------GETRHLMHYQFLGWPD-YGVPENGSDVIDVLDAARSMQGCFseyvtdPDRfPLHGpPMVIHC
|.| | .|.     . . |.|  .|.             ||| ....|.  |.    ||   . .|...  .|....        ... | .| |.|...
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv......ded.peeg.Pvvvvs

SAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
| | .||| . ..| ... .. ...|.| | |. ||..|   ... |.| ..| ..||. | 
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
0041856 (Phosphotyrosine protein) phosphatases II 771-1019 1.5e-49 163.4 In-house 1-173 (182) alignment 
Range on Protein: 771-1019
Range on HMM: 1-173/182.0
NSTKNRYKDVICYDSTRvtlnsipdteGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATkcvemrklkCAQYWPDGLntvaqf
| .||||.|...|| .|          ..|||.||.  |..... .|.|||||..||.|..|||.|  . .||..|         . .|||. |      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdisvsvvndvvegayqfrqfvaykngeTRHLMHYQFLGWPDYGVPEnGSDVIDVLDAARSmqgcfseyvtdpdrfplHGPPMVIHCSAGIGRSGTFASL
                            .|. ..|..|.|||.|||.  ....| ......                 .| | ..|||||.||.||.. .
............................erlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlvaa

DYCIDElrmtnKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
....       .|...|.|.|.|..|  ...| .|| |..  .||. |.
ylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 771-1018 5.6e-48 158.3 In-house 33-267 (283) alignment 
Range on Protein: 771-1018
Range on HMM: 33-267/283.0
NSTKNRYKDVICYDSTRVTLNSIPDtegsDYIHANYCN---GYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglNTV
| .|||..... .|  || |.| .     ||| | .      |.. |. | .|.||.||| |.|.|......  ||| ||  |  . ||.||||   .  
nkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rGs

AQFGDISVSVVNDVVEGAYQFRQFVAYKNG---ETRHLMHYQFLGWpdygVPENGSDVIDVLDAarsmqgcFSEYVTDPDRFPlhGPPMVIHCSAGIGRS
 ..|.  |.. ... . ..  ....  .|.   .|  | |||. .|    .  .   .|. |         |   ..   . .    |.|.|||.||||.
edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvk.......fnkvislqtesk..kgPivvhCstgiGrt

GTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
..| ..   .....    |.| . |. .|.||   .|| .|| . .. ||| ||
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 771-1015 8.6e-46 151.1 In-house 3-237 (237) alignment 
Range on Protein: 771-1015
Range on HMM: 3-237/237.0
NSTKNRYKDVICYDSTRVTLNSIpdTEGSDYIHANYCNGYQ-KPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGlNTVAQ
|  |||| ....|| .|| |.      ||||| |.| .|..  ||  | .||||. . .|.|.|.|..   |||| |  .|  .||| .|||.  .  | 
nkiknrygnivaydhsrvvlkga..gsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

FGDISVSVVNDVVEGAYQFRQFVAYKNG---ETRHLMHYQFLGWPDYGVPENGSDVIdvldaaRsmqgcFSEYVTDPDRFPLHGPPMVIHCSAGIGRSGT
.| ..||.  .     |  | ..  |..   | | .  |||  ||| |||.. . ..      |     |   . .  .   .  | .||||||.||.| 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaall......r.....frkniinrsphvsesgpwiihcsagvgrtgi

FASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|  .|  . . .  . |.. . |  . ..| . ||| .|| | ..|.||
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 771-1015 2.5e-45 149.5 In-house 7-238 (239) alignment 
Range on Protein: 771-1015
Range on HMM: 7-238/239.0
NSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQ-KPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglnTVAQ
| .|||| ... || .|| |. . .   |||| |.|   |.  ||  | ||| .. .  |.|||.|..   |||| |  .| .| || |||||   . ..
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

FGDISVSVVNDVVEGAYQFRQFVAYKNGET--RHLMHYQFLGWPDYGVPENGSDVIDVldaARSmqgcfseyVTDpDRFPLhGPPMVIHCSAGIGRSGTF
. .. |.. .  |   |  | ||  . |.|  |.. .|.|  ||| |||.  . |. .    |         .|  | .|    | |||||||.||.|.|
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl...rrk........itk.dslpg.arpwvihcsagvgrtgaf

ASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
  .|  . . .  . |.. . |. .|..| . .|| ||| | . .|||
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 771-1016 3.1e-44 145.9 In-house 38-276 (287) alignment 
Range on Protein: 771-1016
Range on HMM: 38-276/287.0
NSTKNRYKDVICYDSTRVTLNSIPDtEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGlNTVAQF
.  |||| ||. .| ||| |   ..  ||||| |||  .|.. .  | .|||.  ||.|.||...|... .... |. ||  .||| .|||.  .   . 
avkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GDISVSVV-NDVVEGAYQFRQF-VAYKNGET-RHLMHYQFLGWPDYGVPENGSDVID-VLDAARSMqgcfsEYVTDPDRfplHGpPMVIHCSAGIGRSGT
|  || ..  |. |  |  | . ..  ...  | .  ...| ||| ...     .|  |||  . .     |   | .     | |.|.|...||||||.
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhi.....elardase...vG.PlvvhddvGiGrsGi

FASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEY
. ..  ... |  . .|.|   |  ||..||  .|.  |. . |...  |
llatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 771-1018 7.3e-44 144.6 In-house 55-290 (305) alignment 
Range on Protein: 771-1018
Range on HMM: 55-290/305.0
NSTKNRYKDVICYDSTRVTLNSIPdteGSDYIHANYCNGYQKP-KGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQ
. |||||.|| | | . | |.  .    ||||||||      | | .| .|||| .|....| |. .. |  |||  | ||. |||||||||       .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

F-GDISVSVVNDV--V--EGAYQFR-QFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyVtdpdrfplhgpPMVIHCSAGIGR
. . | |  |     .  .   |     ..|  ...  . | |.  ||| |||      ...| | |  .      |           |.|.||||||||
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk......v...........pivvhcsagigr

SGTFASLDYCIDELRMTNKV-NVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
.||  ...| ....   ...  . | |. ||.|||||||.| || | .. .|.| |
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 771-1019 4.6e-33 109.3 In-house 33-261 (267) alignment 
Range on Protein: 771-1019
Range on HMM: 33-261/267.0
NSTKNRYKDVICYDSTRVTLNsipdTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMrklKCAQYWPDGLNTVAQF
|  .||. |.. || ||| |     |.  .|| | | .||.. .  |.||.||| |. |.. .. ...| |||. ||  .    .  ..||  .    ..
nqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakky

GDISVSVVNDVVEGAYQFRQF-VAYKNGETRHLMHYQFLGWpdyGVPENGSDVIdvldaaRSMQGCFSEyvtdpDRFPLHGPPMVIHCSAGIGRSGTFAS
 |..|    .  |  ||   . . .||  .. .  | .  |    .  |    .      . . | ...     ...   ..|.|..||.|.||||||  
qdltvehslekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpyl......kplfgilak.....nqlengnrPlvvacsdGvGrsGtflv

LDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALY
.|  .. ..  . ... . .| .|.||   ..| |.| ...... ||| .
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_egg_pd Subfamily egg 771-906 2.3e-22 74.1 In-house 40-178 (307) alignment 
Range on Protein: 771-906
Range on HMM: 40-178/307.0
NSTKNRYKDVICYDSTRVTLNSIPDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMrkLKCAQYWPDGLNTVAQF
| .| | | | | ||.||.|.        |.||||. .|       ||.| ||| ||.|.|||....||  ||| |  .|    .|  |||   .  ...
nlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvt

--GDISVSVV--NDVVEGAYQFRQF-VAYKNGETRHLMHYQ
  | . .  .  ..  .  ..  .. .   . | |.| |.|
vpGslrienlkvdskadplfrvtklklvGgddeerflehwq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 771-843 2.9e-07 24.3 In-house 37-114 (347) alignment 
Range on Protein: 771-843
Range on HMM: 37-114/347.0
NSTKNRYKDVICYDSTRVTLNSI-----PDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIV
. .||| |||   |.||| |        .  .   || | . .  .  |  |||| ||  || |.|.|.    |  .|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 772-1007 2.7e-33 110.0 In-house 51-271 (301) alignment 
Range on Protein: 772-1007
Range on HMM: 51-271/301.0
STKNRYKDVICYDSTRVTLnsIPDTEGsDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFG
  |.||. | |  || | .  | | .    ||||. .   .|.  | |||||| | .|.| ||   .|  ||| .. ||  . ||..| |   .   . |
kdkhryptvPckPstavev..ivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

DISVSVVN--DVVEGAYQFRQFVA---YKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSmqgcfSEYvtdpdrfplhgpPMVIHCSAGIGRSGT
  .. ..|   ...   . |..      .. .|| ..|||.  |.|.|||.   .. |... ..      ||             |.|.||||||||| .
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk.....sek............PivvhcsaGiGrsva

FASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYA
| . .|   |.   ......| .. ||..|  ..|| .|  
figteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 772-1018 5.7e-25 83.0 In-house 20-257 (290) alignment 
Range on Protein: 772-1018
Range on HMM: 20-257/290.0
STKNRYKDVIcYDSTRVTLNSIPDTEGSDYIHANYCNgYQKPKGIILTQGPLKRT-------VNDYWRMLWEKEVFVIVMATKCVEMR----KLKCAQYW
. ..|..  .    ||| |.       .||||||.   . .   .|||| |....       ....| |  . .|  .||  .  | .    .  ||.| 
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PDGLNTVAQFGDISVSVVNDVVEGAYQFRQF-VAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSmqgcfseyV-TdpdrfplhgpPMVIHCS
|.  ..  .|....|.  . . |   . |.  | . ..|   . |... || .  |.|.   ......  .           |          |...|| 
pesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvka........skt..........pvivHcv

AGIGRSGTFASLDYCIDELR-MTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLeyaL
 || || ..|...     .  ....|.... .  ||.|||  |......||    ..   |
dGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...l
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 772-863 1.6e-18 61.6 In-house 48-153 (350) alignment 
Range on Protein: 772-863
Range on HMM: 48-153/350.0
STKNRYKDVICYDSTRVTLNSIP--------DTEGSDYIHANYCNGY----QKPKG--IILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCA
 .|||||... |. .|| |.  .         ....||| ||| .      .   .   | ||.||..||.|..... . .| ||.. |. ||.   || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPDG
.||..|
rYWqeg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 772-863 6.5e-09 29.6 In-house 49-156 (349) alignment 
Range on Protein: 772-863
Range on HMM: 49-156/349.0
STKNRYKDVICYDSTRVTLNSIPD-----------TEG---SDYIHANYCNG--YQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLK
 .||||||.. |. .|| |.  .            ...    ||| ||| .   ..  |  | || ||  ||.|.....  ..| ...  ..  |    |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CAQYWPDG
| .|| ..
cdiywqel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 774-1025 1.1e-31 104.8 In-house 46-283 (312) alignment 
Range on Protein: 774-1025
Range on HMM: 46-283/312.0
KNRYKDVICYDSTRVTLNSipdtEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVaQFGDI
 ||| .. |.|  | ||      .   |||||. .   ||. .. |||||. |.  .|..        |.. .  ||    |||.|  | .  | .. | 
lnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfv.dledh

SVS--VVNDVV-EG------AYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSmqgcfseyvtdpDRFplhgpPMVIHCSAGIGRS
 |    . ..   |      ...  . |    |.  .| |||.  |||.|.|.       .| | .             |.      |.. |||||.||.
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk............dkk.....pviahcsagvgrt

GTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYaLYLKAALK
||.| ..  |  ||   | ||..   |||..|| |...  || .. ..|||. || |.  |
gtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef.lyskglyk
subfamily_eak_pd Subfamily eak 774-1020 6.8e-22 72.3 In-house 55-308 (332) alignment 
Range on Protein: 774-1020
Range on HMM: 55-308/332.0
KNrYKDVICYDSTRVTLNSIpDTEGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDI
.|   ... ||   | | |    .   || |   .  .  .  |||  . .  |  .|.|. |.    ||.  . ||..  |  .|.||    . .|| .
rn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

SVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQFLGWPDYGVPENgSDVID---------VLDAARSMQGCFSEYVtdpdRFPLHGPPM---VIHCSAGI
 |   . | .. ...|...  |  || ...||.. || .. .|    | .          ||  .   . ..| ..    .   | ||    .| .. | 
dverkefvkrniletrllelskGnethrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstl....kkyihtppsfapiiqsarGs

GRSGTFASLDYCID--ELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
 |.|.|  .|  |   . ...|   |.. .   ...|  |. .. |..| |. ||.| |  
araGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
0044763 (Phosphotyrosine protein) phosphatases II 782-1013 1.4e-31 104.9 In-house 1-167 (178) alignment 
Range on Protein: 782-1013
Range on HMM: 1-167/178.0
CYDSTRVTLNSIPDTEGSDYIHANYCNGYqkpkgIILTQGPLkrtvNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNtvaqfgdisvsvvndv
..| ||| |......|.||||.|..  ..     ..|.. |      |....|.|  . .||. |. .|. .||| .|||.. .                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

vegayqfrqfvaykngetrhlMHYQFLGWPDYGVPENGSDVIDVLDAARSMQgcfseyvtdpdrfPLHGPPMVIHCSAGIGRSGTFASLDYCIDElrmtn
                     ..|.....||.|||.  . . ..... .. .             . .| | ..|||||.|||||.. .....       
.....................iqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaaylmkkl.....

KVNVQECVRLLRQQRAfSIQTDEQYAFCYKTV
.....|...|.|..|   .....|. ..|.  
glsleeaielvrerRp.ivpnpgqlrqLyefe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 788-863 1.1e-06 23.0 In-house 10-72 (130) alignment 
Range on Protein: 788-863
Range on HMM: 10-72/130.0
VTlnsipdteGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKcVEMRklkcAQYWPDG
.         | .||.|..    .. .  .||| ||  |  |.|.|. |. | |.|.    ||       .|||| 
lq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpds
0046846 (Phosphotyrosine protein) phosphatases II 795-1016 5.7e-39 129.0 In-house 8-172 (176) alignment 
Range on Protein: 795-1016
Range on HMM: 8-172/176.0
DTEGSDYIHANYCNGYQkpkgIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglntV----Aqfgdisvsvvndvvegayqfrq
. ...|||.||.  |.      | ||||| ||. |...||.|  . ..|. |..||. .|||..|||.    .                           
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi......................

fvaykngetrhlmHYQFLGWPDYGVPENgSDVIDVLDAARSMQgcfseyvtdpdrfpLHGPPMVIHCSAGIGRSGTFASLDycideLRMT-NKVNVQECV
             .|..|.|||.|||.  ......|.. |...               .| | ..||||||||.||.. ..     | .. . ..|.|..
.............qylhlpwpDhgvpdl.elllellefireal..............keggpvlVHCsaGigRtgtlvaay.....llelekglsveeal

RLLRQQRA-FSIQTDEQYAFCYKTVLEY
.|.|.||  ...||.||| |.|. .|..
alvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 797-1010 2.3e-41 136.7 In-house 3-154 (172) alignment 
Range on Protein: 797-1010
Range on HMM: 3-154/172.0
EGSDYIHANYCNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCvemrklkcaqywpdglntvaqfgdisvsvvndvvegayqfrqfVAYKN
||||||.|.| ..| .|. .| ||||| .|..|.||||.|. . .||..|..                                           . .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GETRHLMHYQFLGWPDYGVPeNGSDVIDVLDAARSMQgCFSEyvtdpdrfplhGPPMVIHCSAGIGRSGTFASLDYCIdelrmtNKVNVQECVRLLRQQR
...|. ..|..|.|||.||| . . ....|.  .... . |.           | |...|||||.||.||.. .....       .....|.|.|.|..|
llerlgiqylylpwpDhgvp.llellleflefidell.alsp...........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekR

AFSIQTDEQYAFCY
  ..|...|| |.|
pgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 798-1020 4.5e-47 156.3 In-house 3-228 (272) alignment 
Range on Protein: 798-1020
Range on HMM: 3-228/272.0
GSDYIHANYCNGYQK---PKGIILTQGPLKRTVNDYWRMlWEKEVFVIVMATKCVEMRKLKCAQYWP----------DGLNTVAQFGDISVSVVNDVVEG
 |.||.|.. .|| .   |. .....|||. |..|.||. .|  . .||. ....|. .||| .|||          |   .   .|...| ..  ..  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

AYQFRQFVAY---KNGETRHLMHYQFLGWPDYGVPENGsdVIDVLDAARSmqgcfseyvtdpdrfplhGPPMVIHCSAGIGRSGTFASLDYCIDELRMTN
 |  | ....   ..||.|..||.....|||.|||..   ....|.. ..                  | |...|||||..|.||.. |....  . .. 
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..................ggpvlvHCsaGkdRTGtvvallllllgvslet

KVN--------VQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
 |.        ..|.|. ||.||. ..||.|||.|.|. .||.. .|
ivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 798-1011 8.7e-43 141.3 In-house 1-164 (174) alignment 
Range on Protein: 798-1011
Range on HMM: 1-164/174.0
GSDYIHANYCNGYQKPKGIILTQGPLKrtvndYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDglntvaqfgdisvsvvndvvegayqfrqfvaYKNG
|||||.|......  ....|..||||.     .|.||.|  . ..|| ....|. . || .|||.                               ... 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

ETRHLMHYQFLGWPDYGVPENGSdVIDVLDAARSMQgcfseyvtdpdrfpL--HGPPMVIHCSAGIGRSGTFASLDYCIDELRmTNKVNVQECVRLLRQQ
..|. ..|..|.|||.|||.    .......... .              .  .| |...|||||.||.||.. .....  |. .. |.. . || ||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveeal..............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlq

RAFSIQTDEQYAFCYK
|  ..||..|| |.|.
rpgmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 798-1014 8.2e-31 102.0 In-house 2-150 (151) alignment 
Range on Protein: 798-1014
Range on HMM: 2-150/151.0
GSDYIHANYCNGYqkpkgIILTQGPLKrtvnDYWRMLWEKEVFVIVMATKCVEMRklKCAQYWPD-Glntvaqfgdisvsvvndvvegayqfrqfvaykn
 ||||...|  |.     .....|||     |....|.|  . .||. .. .|.   .|..|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

getRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSmqgcfseyvtdpdrfpLHGPPMVIHCSAGIGRSGTFASLDYCIdeLRmtnkVNVQECVRLLRQQR
   ....|...|.|||.|.|..   |...|.....                  . |...|||||.||.||.. |. ..  |.    |...|... .|..|
...ievlhipildwpdpglplsfdavleflellld................kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkr

AFSIQTDEQYAFCYKTVL
  ..|. .|. |... .|
pgvvqpnqqflfqlfall
0049260 (Phosphotyrosine protein) phosphatases II 807-1011 8.6e-36 118.3 In-house 2-144 (152) alignment 
Range on Protein: 807-1011
Range on HMM: 2-144/152.0
CNGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWpdglntvaqfgdisvsvvndvvegayqfrqfvaykngetrhlmHYQ
 .|| .|. .| ||||.  |..|.||||.|  . .||| |...|. ||||.||.                                           .|.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FLGWPDYGVPENGSDVIDVLDAARSM---QGCfseyvtdpdrfplhgpPMVIHCSAGIGRSGTFASLDYCIdelrmtNKVNVQECVRLLRQQRAFSIQTD
.| |||.|||..   ....|.. . .   .|.                | ..|||||.||.||.. .....      ..|...|.|.|.|..|  .... 
hlpwpDhgvpdlsqlllflllfieklaldkgg................pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnp

EQYAFCYK
.|. |.|.
gqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 808-1013 2.9e-20 67.0 In-house 230-434 (440) alignment 
Range on Protein: 808-1013
Range on HMM: 230-434/440.0
NGYQKPKGIILTQGPLKRTVNDYWRMLWEKEVFVIVMATKcveMRKLKCAQYWPDGLNTVaQFGDISVSVVNDVVEGAYQFRQFVAYKNGETRHLMHYQF
.|| | . .| || ||  || |.||.. . ..  |.|  .   .    |. |||    .|  || ..|           . | .    . |   .  .. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrsv.tfgpftvghkgsenmnrvkvrtlelkykeevheirqfev

LGWPDY----GVPENGSDVIDVLDAARSMQGCFSEYVTDPDRfPLHGPPMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTD
  || .    ||  .   .  ||.    .. |  .  |.  | |  |||...|| .||  || | ..  |...|     ..| . .||||  |   . | 
qtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsr.pgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl

EQYAFCYKTV
 .| .||| .
tdyllcykll
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 816-1011 1.3e-18 61.9 In-house 7-198 (199) alignment 
Range on Protein: 816-1011
Range on HMM: 7-198/199.0
IILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNG----ETRHLMHYQFLGWP
 | || ||. |. |.|.|.||     |||       ..   . |||   ......| .||..   ...  |    ..  .|      || . ||||  | 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DYGVPeNGSDVIDVLDAARSMQgcfSEYVTDPDrfplhgPPMVIHCSAGIGRSGTFASLDYCID--ELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFC
.   | | .  .  . |.| .      |  . |       |...||| | | .| | .||  .   |   |  |.. |  . ||| |   | . ..| | 
ekttp.nvalfvgfvvasrevs...kkyeqekd......apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YK
|.
yq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 816-1011 1.3e-18 61.9 In-house 6-197 (198) alignment 
Range on Protein: 816-1011
Range on HMM: 6-197/198.0
IILTQGPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKNG----ETRHLMHYQFLGWP
 | || ||. |. |.|.|.||     |||       ..   . |||   ......| .||..   ...  |    ..  .|      || . ||||  | 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DYGVPeNGSDVIDVLDAARSMQgcfSEYVTDPDrfplhgPPMVIHCSAGIGRSGTFASLDYCID--ELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFC
.   | | .  .  . |.| .      |  . |       |...||| | | .| | .||  .   |   |  |.. |  . ||| |   | . ..| | 
ekttp.nvalfvgfvvasrevs...kkyeqekd......apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YK
|.
yq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 816-876 8.1e-06 19.6 In-house 139-194 (244) alignment 
Range on Protein: 816-876
Range on HMM: 139-194/244.0
IILTQGPLKRTVNDYWRMLWEKEVFVIVMATKcVEMRklkcAQYWPDGLNTVAQFGDISVS
 |||| ||  |  |.|.|. |. | |.|.    ||       .||||         ||.|.
yiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeeditvt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 821-1009 3.5e-15 50.3 In-house 98-280 (302) alignment 
Range on Protein: 821-1009
Range on HMM: 98-280/302.0
GPLKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVnDVVEGAYQF---RQFVA----YKNGETRHLM-----HYQFL
 | | |.. .| .. . .| ..|  .. ||  . |||.|. | .. . .||  .|  | .| .   .|   ..|.     .|| .... .       .| 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktv.svktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWPDYGVPENGSDVIDVLDAARSmqgcfseYVTDpdrfplhgppMVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAF
.|||.| |..    .|.|    |       | ..          ...|||||.||.||. .. | |.     .  .. . |  .|| |  ..|...|  .
awpdhGapkeaytaldilkfces.......ykkn..........vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

C
 
l
subfamily_hpo-7_pd Subfamily hpo-7 823-933 1.8e-11 38.4 In-house 43-155 (263) alignment 
Range on Protein: 823-933
Range on HMM: 43-155/263.0
LKRTVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVN---DVVEGAYQFRQFVAYkNGETRHLMHYQFLGWPDYGVPENG
| .|.. .....  ..  |.|| .   |  . || .|.|  ..   .. ...|.. .   ||.  . .. . .     .|. . ||.. ||..   ||. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpela

SDVIDVLDAARSMQ
 ... .|..||  .
reilnilkvarnsk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 826-1022 1.9e-18 61.4 In-house 40-225 (255) alignment 
Range on Protein: 826-1022
Range on HMM: 40-225/255.0
TVNDYWRMLWEKEVFVIVMATKCVEMRKLKCAQYWPDGLNTVAQFGDISVSVVNDVVEGAYQFRQFVAYKN--GETRHLMHYQFLGWPDYGVPENGSDVI
||. .....  ..  |.|| .   |  . || .|.|  ..   .. |..|.. . . .   . .. ...     .|. . ||.. ||..   ||.  .. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DVLDAARSMQgcfseyvtdpdrfplhgpPMVIHCSAGIGRSGTFASLDYCID----ELRMTNKVNV--QECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
 .| ..|  .                  ..|.|||.||||| .|.  ..        |. |. |..   . .. ||..|. .|.|  | ||.  .||.. 
nilkvvrdsk..................svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

lYLKA
 . |.
.fpkg
0048076 (Phosphotyrosine protein) phosphatases II 892-1015 4.7e-23 76.9 In-house 37-141 (145) alignment 
Range on Protein: 892-1015
Range on HMM: 37-141/145.0
VAYKNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCfseyvtdpdrfplhGPPMVIHCSAGIGRSGTFASLDYCIDelrmtNKVNVQECVRL
  ......|. ..|..|.|||.|||.  ......|.. .. .                | |...|||||.||.||.. .. ..      ..|...|...|
tselellerlgiqylylpwpDhgvpdllellleflefieealke..............ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealel

LRQQRAFSIQTDEQYAFCYKTVLE
.|.|| .......|. |.|. .||
vrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 895-1011 2.1e-21 71.6 In-house 42-139 (144) alignment 
Range on Protein: 895-1011
Range on HMM: 42-139/144.0
KNGETRHLMHYQFLGWPDYGVPENGSDVIDVLDAARSMqgcfseyvtdpdrFPlHGPPMVIHCSAGIGRSGTFASLDYCIdelrmTNKVNVQECVRLLRQ
.. ..|. ..|..|.|||.|||.  ......|.. ..               . .| |...|||||.||.||.. .. ..     .......|...|.|.
pefleregiqylhlpwpDhgvpdllellleflefieea.............le.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrs

QRAFSIQTDEQYAFCYK
.| .......|. |...
rrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 902-1017 8.9e-14 46.0 In-house 217-344 (350) alignment 
Range on Protein: 902-1017
Range on HMM: 217-344/350.0
LMHYQFLGWPDYGVPENGSDVIDVLD-AARSMQGCFSEYVTDPDRfplhGPPMVIHCSAGIGRSGTFASLDYCID---ELRMTN----KVN--------V
... |.  |.| ..  |  ... .|.     ..  |.|   | .|    ..|...|||||.|| ||. .||. .     |....    |..        .
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnar....sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

QECVRLLRQQRAFSIQTDEQYAFCYKTVLEYA
.  |  ||.||   .|. .|. |.|...| | 
siivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 902-1017 2.7e-09 30.8 In-house 220-344 (349) alignment 
Range on Protein: 902-1017
Range on HMM: 220-344/349.0
LMHYQFLGWPDYGVPENGSDVIDVLDAARS-MQGCFSEYVTDPDRFplhgPPMVIHCSAGIGRSGTFASLDYCIDELRMT----NKVNVQE--------C
|.  |.  |.| ..  |   ..  |.     .   |..   | |.     .....||||| ||.|..  ||. .. | ..    ||...|          
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdql....stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VRLLRQQRAFSIQTDEQYAFCYKTVLEYA
|  ||.||   .|   |. ..|...|.| 
vnelrkqrismvqnlaqfiaiyealLkyf
PTPc_DSPc_SM00012 903-1015 6.7e-32 105.2 In-house 3-105 (105) alignment 
Range on Protein: 903-1015
Range on HMM: 3-105/105.0
MHYQFLGWPDYGVPENGSDVIDVLDAARSMQGCFSEyvtdpdrfplhGPPMVIHCSAGIGRSGTFASLDYCIDELRMT-NKVNVQECVRLLRQQRAFSIQ
.||...|||| ||||........|.| .. .   ..           ..|.|.|||||.||.|||. ||.... |. . ..|.....|. ||.||. ..|
khyhytgwpdhgvPeesdsilellravkknknkses...........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvq

TDEQYAFCYKTVLE
|.||| |.|. .||
teeqylflyralle
subfamily_PTPDC1_pd Subfamily PTPDC1 950-1010 1.4e-06 22.9 In-house 115-169 (182) alignment 
Range on Protein: 950-1010
Range on HMM: 115-169/182.0
GpPMVIHCSAGIGRSGTFASLdYCIdelrMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCY
|  . .|| || || |   .  | .     ..... .. ..|.|..|. |||| ||  .. 
g.kvavhChaGlGrtGvliac.ylv....yakrltaekaiklvrskrpksiqtreqvelvk
0038934 (Phosphotyrosine protein) phosphatases II 950-1011 7.9e-06 21.1 In-house 115-171 (194) alignment 
Range on Protein: 950-1011
Range on HMM: 115-171/194.0
GPPMVIHCSAGIGRSGTFASLdYCIDELRMtnkvNVQECVRLLRQQRAFSIQTDEQYAFCYK
|   ..|| ||.||.||..   | |  |.|    ...|...|.|. |  .|.. ...   .|
ggvvaVHCkaGlgRtGtlvaa.YLiyrlgm....saeeAialfrekRpgaipnqdyleallk
subfamily_CG42327_pd Subfamily CG42327 952-1020 2.8e-15 50.8 In-house 249-318 (319) alignment 
Range on Protein: 952-1020
Range on HMM: 249-318/319.0
PMVIHCSAGIGRSGTFASLDYCIDELRMT-NKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLEYALYL
|.|.||| |.||.|.  . |  | .|  . . |.. . |  .|..|| ...| |||.| ||.. ||| .|
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_egg_pd Subfamily egg 952-1014 2.2e-09 31.5 In-house 203-267 (307) alignment 
Range on Protein: 952-1014
Range on HMM: 203-267/307.0
PMVIHCSAGIGRSGTFASLDYCIDEL-R-MTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVL
|.|...  |. ...|. ...  . .| |  . |  |...| .||..| .|...  .| | |. ||
pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
PTPc_motif_SM00404 952-1006 4.9e-06 21.5 In-house 82-130 (140) alignment 
Range on Protein: 952-1006
Range on HMM: 82-130/140.0
PMVIHCSAGIGRSGTFAsLDYCIDelrmTNKVNVQECVRLLRQQRaFSIQTDEQY
  ..|| ||. ||.|.. . |...    .......|........|  .|.  ...
kvlVHCqaGvSRSatli.iaYlmr....yrqlslaeayefvkerR.piispnlnf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 953-1015 1.8e-06 22.3 In-house 1-63 (69) alignment 
Range on Protein: 953-1015
Range on HMM: 1-63/69.0
MVIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
||.|||.| ||.||| ..   .  ..    |.. . |. .|. |   .  . .| | . .. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_hpo-7_pd Subfamily hpo-7 953-1018 2.2e-06 21.8 In-house 157-228 (263) alignment 
Range on Protein: 953-1018
Range on HMM: 157-228/263.0
MVIHCSAGIGRSGTFASLDYCID----ELRMTNKVNV--QECVRLLRQQRAFSIQTDEQYAFCYKTVLEYAL
.|.|||.|||||  |.  .         |. |. |..   . .. ||..|. .|.|  | ||   .||.. |
lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 954-1015 9.4e-06 19.9 In-house 1-62 (69) alignment 
Range on Protein: 954-1015
Range on HMM: 1-62/69.0
VIHCSAGIGRSGTFASLDYCIDELRMTNKVNVQECVRLLRQQRAFSIQTDEQYAFCYKTVLE
|.|||.| ||.||| ..   .  ..    |.. . |. .|. |   .  ...| | . .. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve