Gene PTPRD-12 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP065_AA protein Get Run
AqueP065_AA_789-922 phosphatase_domain Get Run
AqueP065_AA_936-1211 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 293-375 2e-13 43.5 Pfam-A 3-83 (85) alignment
Range on Protein: 293-375
Range on HMM: 3-83/85.0
VDDIMFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
. .. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp

fn3 Fibronectin type III domain 398-469 3.7e-13 42.6 Pfam-A 11-84 (85) alignment
Range on Protein: 398-469
Range on HMM: 11-84/85.0
KNPDAINIIWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYGIFGLIPNTSYTIGVRAYTSIGPGDW
 ... ... |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | | .
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

Herpes_gE Alphaherpesvirus glycoprotein E 571-656 9.4e-07 17.5 Pfam-A 329-407 (439) alignment
Range on Protein: 571-656
Range on HMM: 329-407/439.0
QPIPPADIPTSTSDAANGSSAIFIA-IGAVVCILVLIVIIAIIVVVIVLKKRRSSKNIdivskntSANKPEATVYYSTCKNNNnDAG
.. |... |....   ....| . . ..||....||.......|.|.| |.|| ..         .  .|...|| |  .|.   . 
sdppatpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkaye.......krlspfspvYtsLPtnel.ved

DUF4577 Domain of unknown function (DUF4577) 576-635 9.1e-06 12.1 Pfam-A 46-100 (128) alignment
Range on Protein: 576-635
Range on HMM: 46-100/128.0
ADIPTSTSDAANGSSAIFIaigaVVCILVLIVIIAIIVVVIVLKKRRSSKnIDIVSKNTS
 .|| . .|. ||| ..|.    |  |||||| .|... || |  .   | .| ||.  .
ekipdagtdpgngsrglff....vglilvlivslalvsfviflivqtgnk.mddvsrrlt

Ig_3 Immunoglobulin domain 678-752 1.5e-07 23.5 Pfam-A 1-75 (75) alignment
Range on Protein: 678-752
Range on HMM: 1-75/75.0
KPVIEEFPSNMTTEEGCqVLLKVKVKETS-KPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHEGTYRFVANN
||||   ||...|..|  | |   .. .. .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN

Ig_2 Immunoglobulin domain 678-765 1.4e-06 20.3 Pfam-A 1-80 (80) alignment
Range on Protein: 678-765
Range on HMM: 1-80/80.0
KPVIEEFPSNmtTEEGCQVLLKVKVKETSKPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHEGTYRFVANND-AGTVSQQVVLTV
|||... |..   .||..| |  ...   .|.. ||..||...   .        |.. .|.... |||. .| |.  ...|. | .||
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv

I-set Immunoglobulin I-set domain 679-765 5.8e-15 46.9 Pfam-A 1-90 (90) alignment
Range on Protein: 679-765
Range on HMM: 1-90/90.0
PVIEEFPSNMTTEEGCQVLLKVKVKETSKPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHEGTYRFVANNDAGTVSQQVVLTV
|.... .......|| .| |...|... .||..|...|.... .  .... ..   .| . .||.. ||.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

0051299 (Phosphotyrosine protein) phosphatases II 785-911 5.3e-33 110.1 In-house 3-136 (288) alignment
Range on Protein: 785-911
Range on HMM: 3-136/288.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGP
. |.|... |.| . .|.|.  .. .| .| |    .. ...|   |.  ||. .|. ||..|..|....|  . .. |||| |.||| .. ..||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

MSKTLVDFWCLVWQERPPVIVMVTNH---------Q
...|. ||| .||... .||||.|.          |
lpntvedFWrmvweqnvrvIvmltklvelgrekcaq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 785-909 4.2e-28 93.3 In-house 3-124 (319) alignment
Range on Protein: 785-909
Range on HMM: 3-124/319.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEhSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGP
. |.|... . . . ...|.  .. .| .|. .... . .      ||  ||. ||. ||  |..| .. | ..   .|||| ..|||    ..||||.|
teievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaP

MSKTLVDFWCLVWQERPPVIVMVTN
...|. ||| .||.|.  ..||.|.
lentiedfWrmvWeeessivvmltk

subfamily_PTPRB_pd Subfamily PTPRB 785-909 3.5e-27 90.2 In-house 5-127 (293) alignment
Range on Protein: 785-909
Range on HMM: 5-127/293.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGP
. | ...| ..|.. .|. . .|. .. .| . ..... ..  .. |.  ||. ||. || .|. | .......   .|||| |..||.|  ..||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynsprefiatqGP

MSKTLVDFWCLVWQERPPVIVMVTN
. .|. ||| .||...  .|||.|.
lpetvddfWrmvwekkssiivmltq

subfamily_PTPRA_pd Subfamily PTPRA 785-910 5.1e-25 83.1 In-house 12-135 (330) alignment
Range on Protein: 785-910
Range on HMM: 12-135/330.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGP
  .|| .. . .    |   . |. .|  | .|. . .  .     ||  ||. ||. || .|.|| ...|...   .|||| ..|||    ..||.|||
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees..dyinasfidGykekdkfiaaqGP

MSKTLVDFWCLVWQERPPVIVMVTNH
 ..|. ||| ..|. .   |||.|. 
keetvedfwrmiweqksativmltel

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 785-911 1.6e-19 65.2 In-house 8-127 (297) alignment
Range on Protein: 785-911
Range on HMM: 8-127/297.0
NLIPVRQFGKFVANGHAKgkEEFKTQFTMLdsGES-EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYSSdyQYIATQG
. ||. .|  .| ...    . |. .|  |   |.  ...||     |   .|..||. || .|..|. .   .|   .|.|| .| |.    ..|.|| 
rpiplsdfatlvqknrht..dvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqm

PMSKTLVDFWCLVWQERPPVIVMVTNHQ
||  |. ||| .|..|.. .|||... .
PmkatvadfWamvldeqvstivmlnddn

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 786-910 3.6e-62 204.8 In-house 1-125 (290) alignment
Range on Protein: 786-910
Range on HMM: 1-125/290.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPHEYINACYVDGYSSDYQYIATQGPM
|||| .||.|||||||||.| |..||.|||||||||..||||.||||||||||||||||||||.||||||||||..|||||||..||. ..||||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SKTLVDFWCLVWQERPPVIVMVTNH
|.|||||| |.|||. ..|||.|| 
sntlvdFWkliwqekvtiivmltni

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 786-910 1.5e-51 170.0 In-house 1-120 (287) alignment
Range on Protein: 786-910
Range on HMM: 1-120/287.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDS-GESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRpisghkDCPHEYINACYVDGYSSDYQYIATQGP
||||..||.|||.|||||.|.||.|||.|.. ...|.. |....|.|| .||...|.|.|..|..|.      .. ..||||...|||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

MSKTLVDFWCLVWQERPPVIVMVTNH
|..|...||.|........|||....
mfntarnfWkliddrnvtaivmlcqe

subfamily_PTPRD_pd Subfamily PTPRD 786-910 2.1e-36 120.7 In-house 4-125 (564) alignment
Range on Protein: 786-910
Range on HMM: 4-125/564.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGeSEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPM
 ||| .. ..||. .|... .|....  ...| .... ..   . ||  ||.|||| || .|..|... |....  .|||| ..||| .. .|||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

SKTLVDFWCLVWQERPPVIVMVTNH
..|. ||| .||...  .|||.|. 
aetiedFWRmvweqnsstiVmltkl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 786-909 1.5e-29 98.1 In-house 3-122 (305) alignment
Range on Protein: 786-909
Range on HMM: 3-122/305.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGesEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKdcPHEYINACYVDGYSSDYQYIATQGPM
 | . .. ... . ... ......|. .| .   |.|  || .. ||  ||...|...||.||||.. . ..   ..||||.|||||..  .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

SKTLVDFWCLVWQERPPVIVMVTN
 .|..||| |...|.. .|||.|.
kntvadfWrliveekvstivmltk

0045450 (Phosphotyrosine protein) phosphatases II 786-913 2.2e-28 95.3 In-house 8-144 (307) alignment
Range on Protein: 786-913
Range on HMM: 8-144/307.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGES--EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkDCPHEYINACYV--------DGYSSD
.|..... ..|.  ...... .. .| .| | .    .. ...|.  || .||. .|. ||..|..| ...|. . .. |||| ||        ||| ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYI
 ..||||||...|. ||| ..|...  ||||.|.  . 
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 786-909 4.6e-23 76.6 In-house 5-125 (315) alignment
Range on Protein: 786-909
Range on HMM: 5-125/315.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGEsEHSATVGLSSSNKLLNRFANIVVYDDNRIILrPISgHKDCPHEYINACYVDGYSSDYQYIATQGPM
 ||. |.  .||. .|  |. || ..  .  |.  |   |   . ||  ||. ||. ||  |. | |.   .|   .|.|| ..|||.   .|||.||| 
pipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidGynkkrryiaaqgpn

SKTLVDFWCLVWQERPPVIVMVTN
  .. ||| ||..|    |||.||
vasvkdfwrlvfeedigkivmltn

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 786-910 3.7e-21 70.0 In-house 3-122 (392) alignment
Range on Protein: 786-910
Range on HMM: 3-122/392.0
LIPVRQFGKFVANGHAkgKEEFKTQFTMLDSGEsEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPM
 ||| ||  || . .      |  .|  | . .  .  ||.    |.  ||. ||. || .|..|  |    |  ..|.|| |.... ..  |||.||| 
pipvaqfpafveknrh..salffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpn

SKTLVDFWCLVWQERPPVIVMVTNH
. .| ||| .|.||..  |.|||. 
aaslddfwrmvfqenvttiamvtkl

subfamily_PTPRG_pd Subfamily PTPRG 787-909 6.4e-32 105.5 In-house 1-124 (563) alignment
Range on Protein: 787-909
Range on HMM: 1-124/563.0
IPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEH--SATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPhEYINACYVDGYSSDYQYIATQGP
.||..| | ||. ||.|.  |. .|  | |   ..   |.     .||  ||  ||| ||  |. |.|..|.|.   .|||| |.|||    ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MSKTLVDFWCLVWQERPPVIVMVTN
. .|. ||| ..|...  .|||.||
lkdtfddFWrmiWeqnvaiivmitn

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 787-910 1.5e-30 101.4 In-house 2-123 (318) alignment
Range on Protein: 787-910
Range on HMM: 2-123/318.0
IPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMS
|.|... . |.. ...|. ...... .|.  |.. ...  |.. ||  ||.|||. ||. |. |....|...   .|||| |.||| .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegs..DyinanyidGyrrkkayiaaqaPlp

KTLVDFWCLVWQERPPVIVMVTNH
.|. ||| .||.    ||||.|. 
etieDfWrmvWeqnsavivmltqe

0043336 (Phosphotyrosine protein) phosphatases II 787-911 3.4e-26 87.8 In-house 2-123 (278) alignment
Range on Protein: 787-911
Range on HMM: 2-123/278.0
IPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESeHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMS
|.| .. |.... ....|  .. .|  |.|     . ...|.  || .||. .|. || .|..| ...|. |  . |||| |||||.   ..||||||..
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlp

KTLVDFWCLVWQERPPVIVMVTNHQ
.|. ||| .||... ..|||.|.  
etvedFwrmvwelgvttivmLtelv

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 787-911 2.8e-22 74.0 In-house 3-122 (315) alignment
Range on Protein: 787-911
Range on HMM: 3-122/315.0
IPVRQFGKFVANGhaKGKEEFKTQFTMLDSGEsEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYSSDYQYIATQGPMS
||| ||  || .   .    |  .|  |   .  .  .|.  . |   ||. ||. .| .|..|  |   ..  ..|||| |. .. .|  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlk

KTLVDFWCLVWQERPPVIVMVTNHQ
 .. ||| .|.||..  |||||. |
asvddfwrmvlqekvttivmvtkkq

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 787-910 8e-21 68.7 In-house 2-120 (515) alignment
Range on Protein: 787-910
Range on HMM: 2-120/515.0
IPVRQFGKFVAN-GHAkgkEEFKTQFTMLdSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISghkDCP-HEYINACYVDGYSSDYQYIATQGP
.|. ||  ||.  .|.     |  .|  |  |   .  ||     |   ||. ||. || .|..|  |    | | ..|.|| |. .. .|  |||.|||
lplaqfPafvnknrht...tlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevin...dnPhsdyfnasyipsfdndkayiasqgP

MSKTLVDFWCLVWQERPPVIVMVTNH
   .. ||| ||.||..  |.|||. 
nkasvddfWrlvlqenvttiamvtkl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 788-883 1.3e-13 45.0 In-house 6-95 (95) alignment
Range on Protein: 788-883
Range on HMM: 6-95/95.0
PVRQFGKFVANGHAKGKEEFKTQFTMLDSgESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpiSGHKDCphEYINACYVDGYSSDYQYIATQG
 |  |   | . |..  .||  .|  .    |  . ||| | .|   ||| ||. ||  |..|   . ..|   .|||||.||||.    |||.||
hvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrds..dyinacfvdgyarkncyiaaqg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 788-874 2.6e-08 27.6 In-house 7-88 (440) alignment
Range on Protein: 788-874
Range on HMM: 7-88/440.0
PVRQFGKFVANGhaKGKEEFKTQFTMLDSGESEHSATVGLSsSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSS
 | .|  .| |   .    |. ....| || |. |   .|  .||. ||. ||..|| .|..|  . |  |   .|||| |..|  |
ivadfadyvqnn..rrsrafedewsllpsglsqpsdiaslp.nnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingies

0050432 (Phosphotyrosine protein) phosphatases II 789-912 1.2e-29 99.0 In-house 28-144 (308) alignment
Range on Protein: 789-912
Range on HMM: 28-144/308.0
VRQFGKFVANghAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisghkDCPHEYINACYVDGY--SSDYQYIATQGPMS
| .. |.. .  |...  ....|  | |    .. .|.|   || .||. .|. || .|..|       | .. |||| |||||   .. ..||||||..
vldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlp

KTLVDFWCLVWQERPPVIVMVTNHQY
.|. ||| .||... .||||.|. ..
ntvedFwrmvweqnvrvIvmLtklve

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 790-909 3.4e-26 87.2 In-house 12-132 (298) alignment
Range on Protein: 790-909
Range on HMM: 12-132/298.0
RQFGKFVANGHAKGKEEFKTQFTMLDSGES---EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMS
... |..|  ..|.   ....|  |.|..|   |.. .|. ...||  ||.|.|. .|  |..|. ... ...  .|||| ....|.    .||||.|. 
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPlt

KTLVDFWCLVWQERPPVIVMVTN
.|..||| .|..|   .|||.||
etvedFWrmvteedigtiVmltn

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 791-910 3.1e-13 44.1 In-house 8-122 (305) alignment
Range on Protein: 791-910
Range on HMM: 8-122/305.0
QFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisgHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLV
|  ||| .   || . ....|. .   .  .       . ..  ||. ..   |.||. |     .   ||||| | ||   .   ..| || |. ||  
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektca

DFWCLVWQERPPVIVMVTNH
||| . .|..   | |. | 
dfwymclqdkveaifmlcnl

0040438 (Phosphotyrosine protein) phosphatases II 792-913 3.7e-28 94.2 In-house 5-123 (317) alignment
Range on Protein: 792-913
Range on HMM: 5-123/317.0
FGKFVANGHAKGKEEFKTQFTMLDSGESEhSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVD
. ...   .....  .. .| .|.|   . . .|..   || .||. .|. ||..|..| |..|  | .. |||| ||||..   ..||||||...|. |
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWCLVWQERPPVIVMVTNHQYI
|| .||...  ||||.|.  . 
FwrmvweqgvtvivmLteleel

subfamily_Ptp69D_pd Subfamily Ptp69D 792-910 5.7e-26 86.3 In-house 9-125 (307) alignment
Range on Protein: 792-910
Range on HMM: 9-125/307.0
FGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVD
  . . . . . .. ..  . .| . |...|..|.    |.| ||. .|. .|..|..|..| |..|   .|||| .. ||    ..|| |.|.  |. |
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigD

FWCLVWQERPPVIVMVTNH
|| ....    .|||..| 
fWRmiaeqevtlivmlsnl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 792-908 1.7e-12 41.5 In-house 14-126 (310) alignment
Range on Protein: 792-908
Range on HMM: 14-126/310.0
FGKFVANGHAKGKEEFKTQFTMLDSgESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRpIsgHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVD
. .|.      | | .  |.  ||. . . | |      .   ||....|. |. |. |. |   |   ..|| | ||        .| .|||. .|..|
lenfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk.i..dksryedyihanyvktnylrstficsqgplqhtiid

FWCLVWQERPPVIVMVT
|| ...|||   |... 
fwrmifqeraesilllc

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 793-907 3.8e-17 57.4 In-house 11-122 (325) alignment
Range on Protein: 793-907
Range on HMM: 11-122/325.0
GKFVANGHAKGKEEFKTQFTMLDSGESeHSATVGLSSSNKLLNRFANIVVYDDNRIILRPIsgHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDF
 ..| . .|. .. |  .| .| | ..  . .|     ||  ||| |.| .| .|..|     ..|   .|||| |.  .     ..|.| |...|. |.
vehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindl

WCLV--WQerPPVIVMV
| ||  |.   .|.|..
WrlvldWr..csvvvvl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 794-909 4.5e-25 83.3 In-house 10-123 (288) alignment
Range on Protein: 794-909
Range on HMM: 10-123/288.0
KFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFW
. ||. .|.....|. ..  | . |...| |.|  . |.  ||. ||. || .|. |.     ..   .|||| |.||. .. .|||||||. .|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndfW

CLVWQERPPVIVMVTN
 ||....   |||.|.
elvyenktstivmlte

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 794-909 2.3e-17 57.6 In-house 9-124 (439) alignment
Range on Protein: 794-909
Range on HMM: 9-124/439.0
KFVANGHAKGKEEFKTQFTMLDSGESEH--SATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVD
. | . . . .| ||  | ...| . ..   |..   . ..  ||. ... .|  |..|. | |       |||| |..||  |  |||||||  .|  |
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphs..hyinanyikGyyddklyiatqgpkkettdd

FWCLVWQERPPVIVMVTN
|| ||....   |||.||
fwrlviekktvtivmltn

0039614 (Phosphotyrosine protein) phosphatases II 795-912 4.1e-26 87.6 In-house 22-137 (297) alignment
Range on Protein: 795-912
Range on HMM: 22-137/297.0
FVANGHAKGKEEFKTQFTMLDSGESEhsATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkDCPHEYINACYVDGYSS-DYQYIATQGPMSKTLVDFW
..   .|..|  ....| .| |   .   ...|.  || .||. .|. ||..|..| |. |. | .. |||| |||||.  . ..||||||...|. |||
llllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

CLVWQERPPVIVMVTNHQY
 .||... .||||.|.  .
rmvweqgvtvivmLtklve

subfamily_PTPN9_pd Subfamily PTPN9 795-909 5.1e-22 73.3 In-house 6-118 (297) alignment
Range on Protein: 795-909
Range on HMM: 6-118/297.0
FVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWC
.||  ..|||.  . ... . . . |  ...  . .|   ||..... ||. |. |  .....    .|||| .||||     .||||||. ||  ||| 
lvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedea..sdyinanfvdGykqkkafiatqGplkktvsdfWr

LVWQERPPVIVMVTN
.||...  ||||.| 
mvWeqevlvivmttr

subfamily_PTPN6_pd Subfamily PTPN6 798-910 2.2e-24 81.0 In-house 19-132 (306) alignment
Range on Protein: 798-910
Range on HMM: 19-132/306.0
NGHAKGKEEFKTQFTMLDSGESE--HSATVGLSSSNKLLNRFANIVVYDDNRIILRpisgHKDCP-HEYINACYVDG--YSSDYQYIATQGPMSKTLVDF
... ..|. |. .|  |.  |..  .| . |   .||  ||. ||. .|..|.||.    ... | ..|||| |...   .|| .|||||| ...|. ||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdF

WCLVWQERPPVIVMVTNH
| .||||   ||||.|..
Wrmvwqensrvivmttke

subfamily_ptpA1_pd Subfamily ptpA1 799-909 3.1e-16 54.1 In-house 15-122 (418) alignment
Range on Protein: 799-909
Range on HMM: 15-122/418.0
GHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSsDYQYIATQGPMSKTLVDFWCLVWQ
 | |   . | .| .|.       .. |    |   ||..||.  .  |. |. |  ..    .|||| |.||     |.|.||||. .|. ||| .||.
nhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidgay.pkqfictqgplpntiadfwrmvwe

ERPPVIVMVTN
.|  .|||.. 
nrcriivmlsr

subfamily_PTPRN_pd Subfamily PTPRN 799-911 4.6e-15 50.1 In-house 23-135 (297) alignment
Range on Protein: 799-911
Range on HMM: 23-135/297.0
GHAKGKEEFKTQFTMLDSGESEHSAT-VGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYV-DGYSSDYQYIATQGPMSKTLVDFWCLV
 | | |. .. ..  | . |.| |.. |. .  |   || .... ||..|. |.  . ...  ..||||  . |       |||||||...|. ||| .|
dhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmv

WQERPPVIVMVTNHQ
|..   |||..|. .
weqGvvvivnltrle

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 799-909 2.1e-10 35.1 In-house 10-115 (307) alignment
Range on Protein: 799-909
Range on HMM: 10-115/307.0
GHAKGKEEFKTQFTMLDSGESEhSATVGLSSSNKLLNRFANIVVYDDNRIILRpISGhkdCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQ
   || .... .|..|   . | . ||   |.|   ||. .. . | .||... ..|      .|| | |.       ..|..|||. .|  .||... |
tldkgvqalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiq

ERPPVIVMVTN
|.   ..|. .
ekvesvimlck

0047943 (Phosphotyrosine protein) phosphatases II 800-913 1.7e-28 95.3 In-house 7-114 (273) alignment
Range on Protein: 800-913
Range on HMM: 7-114/273.0
HAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisghKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQE
...|.  .. .| .| |   ... .|.|   || .||. .|. ||..|..|      .| .. |||| ||||| .  ..||||||...|. ||| .||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RPPVIVMVTNHQYI
. .||||.|. .. 
nvrviVmLtelvel

subfamily_PTPN23_pd Subfamily PTPN23 800-911 5.6e-21 69.6 In-house 10-118 (288) alignment
Range on Protein: 800-911
Range on HMM: 10-118/288.0
HAKGKEEFKTQFTMLDSGESEHSA--TVGLSSSNKLLNRFANIVVYDDNRIILRpisGHKDcphEYINACYVDGYSSD-YQYIATQGPMSKTLVDFWCLV
  .|| .....|  |.. . ...   .. ..  .   ||. .|. || ||. ||   |.||   .||||..| . |.   ..||||.|. .|| ||| .|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD...DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WQERPPVIVMVTNHQ
.... .||||.....
yeqkssviVmllske

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 801-911 6.5e-36 118.6 In-house 11-120 (301) alignment
Range on Protein: 801-911
Range on HMM: 11-120/301.0
AKGKEEFKTQFTMLDSGESeHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQER
|| ...|. |.. |..||. .|.|||||..|| |||| ||.|||||||||.| .  . | .||||| |.||||.  ..||.|||| |||||||.|.|||.
akhsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

PPVIVMVTNHQ
|  |||||| .
pvsivmvtnlk

0036941 (Phosphotyrosine protein) phosphatases II 801-912 1.1e-29 99.1 In-house 9-114 (297) alignment
Range on Protein: 801-912
Range on HMM: 9-114/297.0
AKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisghKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQER
....  ....|  |..     | .|.|.  |. .||. .|. ||..|..|      .| .. ||||.|||||. ....||||||...|. ||| .||...
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

PPVIVMVTNHQY
 .||||.|.   
vtvIvmltelve

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 801-909 2.1e-25 84.4 In-house 11-117 (281) alignment
Range on Protein: 801-909
Range on HMM: 11-117/281.0
AKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQER
.. .. |..... | . . ...||   .  |.| ||. ||| ||  |. . | . .|..  .|||| .|.||... .|||||||. ..||.|| .||...
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

PPVIVMVTN
  .|||||.
vsaivmvtr

subfamily_CG7180_pd Subfamily CG7180 802-910 5.5e-21 69.5 In-house 14-119 (296) alignment
Range on Protein: 802-910
Range on HMM: 14-119/296.0
KGKEEFKTQFTMLDSGESEHSAtVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERP
| . |.| .. .    |... |  || . |.  ||  ..| || ||..|. . |...    |||| |||..  . .|| |..|. .|. .|| ||..|  
kfrveyklelkltprleigdCa.gglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeei

PVIVMVTNH
  .|..|..
savvvLtkt

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 802-908 7.2e-08 26.4 In-house 25-128 (305) alignment
Range on Protein: 802-908
Range on HMM: 25-128/305.0
KGKEEFKT--QFTMLDSGESEHSATVGlSSSNKLLNRFANIVVYDDNRIILrpisgHKDCPHEYINACYVDG-YSSDYQYIATQGPMSKTLVDFWCLVWQ
| .|||.   ..|  |  .    |    .  ..  ||.... . | . . |     .|  | .|| | ||      . ..|..|||. .|. .|| .| |
klreefrglakytrpdmtqvafnanqs.adiaitknryqdvpcqdqsavkl.....dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviq

ERPPVIVMVT
..   |||. 
nkveqivmlc

subfamily_PTPN12_pd Subfamily PTPN12 803-909 8.3e-21 69.1 In-house 6-116 (290) alignment
Range on Protein: 803-909
Range on HMM: 6-116/290.0
GKEEFKTQFTMLDS------GESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLV
|.|||...|. | .       |...|...| ...|.  ||. .|. || .|. |. |.....   .|||| .. | ... .|||.|||..||| ||| ..
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeeg..sdYinanfikgvegkleyiaaqgPLpktlddfWrmi

WQERPPVIVMVTN
|. .  ..||. .
weknveivvmaCr

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 804-908 1.9e-19 64.7 In-house 8-107 (283) alignment
Range on Protein: 804-908
Range on HMM: 8-107/283.0
KEEFKTQFTMLdsGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkdcphEYINACYVD---GYSSDYQYIATQGPMSKTLVDFWCLVWQER
 . |. ..  |  .  . .|..  .. ||  ||. .||..| .|. |.. |       .||||...     |  | .||..|.|. .| |||| .|..|.
nklfrevlkrl..svpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

PPVIVMVT
   |||.|
itaivmlt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 805-909 2.4e-18 61.1 In-house 6-105 (267) alignment
Range on Protein: 805-909
Range on HMM: 6-105/267.0
EEFKTQFTMLDSGeSEHSAT--VGLSSSNKLLNRFANIVVYDDNRIILRPISGHkdcpheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPP
 |.. .| ...   |. |.|    ... |.  ||. . . |||.|.|||           |||| ||.||    ..|.||.|...|  ||. .. ... |
ceiekefelikki.sdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvp

VIVMVTN
|||..|.
vivlltk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 805-909 9.3e-13 42.5 In-house 11-114 (281) alignment
Range on Protein: 805-909
Range on HMM: 11-114/281.0
EEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVI
..|| .|. |        .||     |.  ||..|| . |  |. |.     |.   .|| | |.        || ||||  .|  ||| ..|||    |
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkns.tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTN
||. .
vmlcq

subfamily_PTPN1_pd Subfamily PTPN1 806-908 1.4e-15 51.8 In-house 7-103 (290) alignment
Range on Protein: 806-908
Range on HMM: 7-103/290.0
EFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkdcphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIV
 .|. .. ..   |......    .|. |||. ..  ||  ||.|.  .       .||||  |.    . .|| ||||...|   || .||...   .|
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MVT
|. 
mln

subfamily_egg_pd Subfamily egg 806-909 7.4e-11 36.3 In-house 15-116 (307) alignment
Range on Protein: 806-909
Range on HMM: 15-116/307.0
EFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIV
|.. .. .|.    | | |  .|. |.   |   .   |  |. |.   |      ..| | .|.|     ..| .| |.  |  ||| .|.||. . ||
elerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv

MVTN
|.| 
mlts

0046845 (Phosphotyrosine protein) phosphatases II 807-912 1.5e-28 95.4 In-house 2-122 (284) alignment
Range on Protein: 807-912
Range on HMM: 2-122/284.0
FKTQFTMLDSGESEH--SATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkDCPHEYINACYVDGY-----SSDYQYIATQGPMSKTLVDFWCLVWQE
.. .| .| |    .  | .|.|   |. .||. .|..||..|..|....|. .  ..|||| |||||      .  ..||||||...|. ||| .||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RPPVIVMVTNHQ---------Y
. .||||.|.           |
nvrvIVmltelvengrekcaqY

DSPc_SM00195 807-911 6.4e-28 93.2 In-house 2-104 (263) alignment
Range on Protein: 807-911
Range on HMM: 2-104/263.0
FKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkdCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVM
.|..|. |.. .|... | .  ..||  ||. ||..||..|..| .. ..   ...|||| |..|.... .|||||||...|. ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNHQ
.|. .
lteee

PTPc_SM00194 807-911 6.4e-28 93.2 In-house 2-104 (263) alignment
Range on Protein: 807-911
Range on HMM: 2-104/263.0
FKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkdCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVM
.|..|. |.. .|... | .  ..||  ||. ||..||..|..| .. ..   ...|||| |..|.... .|||||||...|. ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNHQ
.|. .
lteee

subfamily_PTPN3_pd Subfamily PTPN3 809-909 1.2e-16 55.4 In-house 19-117 (280) alignment
Range on Protein: 809-909
Range on HMM: 19-117/280.0
TQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRpisghkDCPHEYINACYVD----GYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVI
.|| .|   . . . ..   . |   ||. .|. ||. |..|.      . . .|||| ||.    . .   .|||||||..||  ||| .||...  .|
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMVTN
||.|.
vmltt

subfamily_PTPN13_pd Subfamily PTPN13 810-910 3.3e-17 57.7 In-house 16-111 (273) alignment
Range on Protein: 810-910
Range on HMM: 16-111/273.0
QFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkdcpheYINACYVDGY--SSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMV
.|. |    .  ...|| . .||  ||. |.. ||. |..|   .|       |||| ..        |.|||.|||. .|  ||| .||. .  ||.||
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TNH
|..
tle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 820-909 3.4e-18 60.6 In-house 9-97 (270) alignment
Range on Protein: 820-909
Range on HMM: 9-97/270.0
EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSS-DYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
... ..     .| |||.|.|.     |..| ...   |   .|||| || |... . .|||..||.  || .|| ..|.|. . |||.|.
tsesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttg

0049772 (Phosphotyrosine protein) phosphatases II 820-906 1.8e-14 49.6 In-house 35-126 (314) alignment
Range on Protein: 820-906
Range on HMM: 35-126/314.0
EHSATVGLSSSNKLLNRFANIVVYDdNRIILrPISGHKDcpHEYINACYVDGYssdYQYIATQGPMSKTLVDF----------WCLV--WQERPPVIVM
|.. .|.    |.  ||. .|. .| || || |  ....  . |||| ||||.    ..||||||.. |.|||          | .|  .. .. .|||
eltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

0045098 (Phosphotyrosine protein) phosphatases II 822-913 4.3e-23 77.5 In-house 24-101 (278) alignment
Range on Protein: 822-913
Range on HMM: 24-101/278.0
SATVGLSSSNKLLNRFANIVVYDDNRIIlrpisghkdcphEYINACYVDGYssDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYI
. |..|  .|. .||. .|. || .|..            .|||| |.|||  . ..||||||. .|. ||| ..|... .||||.|. .. 
eitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 822-910 2.3e-16 54.5 In-house 40-138 (350) alignment
Range on Protein: 822-910
Range on HMM: 40-138/350.0
SATVGLSSSNKllNRFANIVVYDDNRIILR----P--ISGHKDCPHEYINACYVDGY------SSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
  . |. .  |  ||. ||. |. .|..|.    .     |   . .|||| |.          .|..|||||.|. .|. ||. .. .   .||...|.
ilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

H
 
d

subfamily_PTPN14_pd Subfamily PTPN14 823-910 1.4e-17 58.7 In-house 41-127 (300) alignment
Range on Protein: 823-910
Range on HMM: 41-127/300.0
ATVGLSSSNKLLNRFANIVVYDDNRIILRPisgHKDCPHEYINACYVDGY--SSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
 ...    |.  ||| ... |.|||. | |    |.  ..||||  .     .....||..|||. .|. ||| .||..   .|||.|..
lstaklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 823-911 2.2e-08 27.8 In-house 42-142 (349) alignment
Range on Protein: 823-911
Range on HMM: 42-142/349.0
ATVGLSSSNKllNRFANIVVYDDNRIILR----PISGH-------KD-CPHEYINACYVD--GYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVT
 . |. .  |  ||. .|. |.  |..|.    .  .        .   ...|||| |.    .| . .||||| |.  |. ||. ..  .. .... ..
lseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

NHQ
. .
ddk

0040439 (Phosphotyrosine protein) phosphatases II 824-913 1.8e-22 75.6 In-house 4-91 (249) alignment
Range on Protein: 824-913
Range on HMM: 4-91/249.0
TVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYI
.|.|   || .||. .|. || .|..| ...|    .. |||| |.||| .  ..||||||...|. ||| ..|...  ||||.|. .. 
svallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 825-910 2.2e-23 77.7 In-house 3-86 (250) alignment
Range on Protein: 825-910
Range on HMM: 3-86/250.0
VGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
|.   .||  ||.|.|. .|  |..| . .| |..  .|||| ...||.    .||||||...|..||| .|..|   .|||.|| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnL

0037934 (Phosphotyrosine protein) phosphatases II 826-911 8.5e-18 60.2 In-house 5-83 (243) alignment
Range on Protein: 826-911
Range on HMM: 5-83/243.0
GLSSSNKLLNRFANIVVYDDNRIILrpisghKDcpHEYINACYVDGYSsdyQYIATQGPMSKTLVD----FWCLVWQERPPVIVMVTNHQ
.|.  |.  ||. .|. ||..|..|      ..  . |||| .....    ..||||||...|. |    || ..|...  ||||.|. .
allpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelv

subfamily_PTPRK_pd Subfamily PTPRK 827-909 6.4e-22 72.8 In-house 39-119 (314) alignment
Range on Protein: 827-909
Range on HMM: 39-119/314.0
LSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
    |.  ||. .|. ||  |..| .| |  |   .|||| ..|.|    ..|.||||. .|. ||| ||..|.   |||.|.
kkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte

0042113 (Phosphotyrosine protein) phosphatases II 827-912 1.9e-21 72.0 In-house 5-88 (245) alignment
Range on Protein: 827-912
Range on HMM: 5-88/245.0
LSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQY
|   || .||. .|. ||..|..| |..|. |..  ||||.|||||    ..||||||...|. ||| ..|...  .|||.|.  .
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 828-908 3.5e-09 31.0 In-house 32-107 (285) alignment
Range on Protein: 828-908
Range on HMM: 32-107/285.0
SSSNKLLNRFANIVVYDDNRIILrpisghKDCPHEYINACYVDGYSSD-YQYIATQGPMSKTLVDFWCLVWQERPPVIVMVT
  .|  |||.|.. . .. |..|      |.  ..|| | ..     |   ||.||||. .|| ||| ...||.   ..|. 
yeanpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlc

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 829-910 1.1e-21 72.6 In-house 23-102 (284) alignment
Range on Protein: 829-910
Range on HMM: 23-102/284.0
SSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
  ||  ||. .|. .| |.. |... |      .|||| .. || .  .|||||||.  || ||| ..|. .   ||..|..
dqnkdknrighilafdknvvklerliGeefs..dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkd

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 829-910 1.1e-21 72.5 In-house 59-138 (319) alignment
Range on Protein: 829-910
Range on HMM: 59-138/319.0
SSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
  ||  ||. ||. .| |.. |... |      .|||| .|.|| .  .|||.|||.  || ||| ..|. .   ||..|..
dqnkdknriinilafdknvvklerliGeefs..dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkd

subfamily_CG42327_pd Subfamily CG42327 829-910 9.2e-10 32.7 In-house 28-106 (319) alignment
Range on Protein: 829-910
Range on HMM: 28-106/319.0
SSNKllNRFANIVVYDDNRIILRPIsGHKDcPHEYINACYVDGYS-SDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
| .|  .|..|.|   . |..|. | | .|   ||..| || ||  .. .|||.| .. ..  ||| .||. .  ||| .|. 
skdk..srvinvvPlPetrvvlqri.gddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 830-909 1.4e-18 62.0 In-house 2-78 (237) alignment
Range on Protein: 830-909
Range on HMM: 2-78/237.0
SNKLLNRFANIVVYDDNRIILRPISGHkdcpHEYINACYVDGYSS-DYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
 ||. ||..|||.|| .|..|.   .      .||||.|..|.     .|||.|||.  .  ||| .||||.  ||||.| 
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltg

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 830-909 5.5e-18 60.0 In-house 7-85 (239) alignment
Range on Protein: 830-909
Range on HMM: 7-85/239.0
SNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYS-SDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
 ||  ||.|||| || .|..|  .|  .|   .|||| |.  |  |   |||||| .. .  ||| ..||||  ||||.| 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 830-909 5.8e-18 59.9 In-house 6-84 (239) alignment
Range on Protein: 830-909
Range on HMM: 6-84/239.0
SNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYS-SDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
 ||  ||.|||| || .|..|  .|  .|   .|||| |.  |  |   |||||| .. .  ||| ..||||  ||||.| 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 830-911 3.5e-15 50.6 In-house 32-111 (297) alignment
Range on Protein: 830-911
Range on HMM: 32-111/297.0
SNKLLNRFANIVVYDDNRIILRPISGHKDcpheYINACYVD--GYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQ
|    ||. .|. .||.|. |.     .|    |||| ||      .|..|| .|||.|.|. ||| ||...   |||||.. |
sslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

Y_phosphatase Protein-tyrosine phosphatase 831-910 9.3e-23 76.2 Pfam-A 1-76 (235) alignment
Range on Protein: 831-910
Range on HMM: 1-76/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|. 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsl

Y_phosphatase Protein-tyrosine phosphatase 831-910 9.3e-23 76.2 In-house 1-76 (235) alignment
Range on Protein: 831-910
Range on HMM: 1-76/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|. 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsl

0041856 (Phosphotyrosine protein) phosphatases II 831-914 5.7e-14 47.6 In-house 1-72 (182) alignment
Range on Protein: 831-914
Range on HMM: 1-72/182.0
NKLLNRFANIVVYDDNRiilrpisghkdcPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYIF
|. .||. .|. || .|            .  |||| ...|.  . ..||||||. .|. ||. ......  .||..|...|  
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 831-907 6.7e-08 26.4 In-house 34-107 (332) alignment
Range on Protein: 831-907
Range on HMM: 34-107/332.0
NKLLNRFANIVVYDDNRIILRPISGHKDcpheYINACYVDGYSSDYQYIATQGPMS-KTLVDFWCLVWQERPPVIVMV
|  .||   . ..| .|. | |  |. |    . || .|||||    || .| |.  .|   || .| . .| .|...
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 832-910 7.5e-20 66.1 In-house 29-107 (274) alignment
Range on Protein: 832-910
Range on HMM: 29-107/274.0
KLLNRFANIVVYDDNRIILRPISGHKDcPHEYINACYVDGYSSDY-QYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
.  ||. .|.  .  |..|.. |....   .|||| |. ||. .   |.|||||...|. ||| ...||. .||||.|. 
qtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 833-909 1.4e-19 65.0 In-house 40-113 (287) alignment
Range on Protein: 833-909
Range on HMM: 40-113/287.0
LLNRFANIVVYDDNRIILrpiSGHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
  ||.|... .||.|..|   | . .   .|||| || .|  | ..||.|||.. |. |||..|...|  .....| 
kknryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 834-908 4.1e-10 33.8 In-house 59-126 (290) alignment
Range on Protein: 834-908
Range on HMM: 59-126/290.0
LNRFANIVVYDDNRIILRpisghKDCPHEYINACYVDGYSSdyQYIATQGPMSKTLVDFWCLVWQERPPVIVMVT
 ||. ..|  |  |.||.        . .|. | ||.|  .   .| |||.. .| .|.| .| ||.  .|||. 
knrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlc

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 834-922 6.5e-08 26.5 In-house 40-128 (347) alignment
Range on Protein: 834-922
Range on HMM: 40-128/347.0
LNRFANIVVYDDNRIILRPIS---GHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQyifINDAVLEF
 ||  .  . |. |..| |     .. | .. |||| ..    .. .|| || |. .|. ||| .|   .   .| . . .    ..|. ||
knrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi...kdeaieef

0046846 (Phosphotyrosine protein) phosphatases II 858-911 1.3e-07 27.0 In-house 9-58 (176) alignment
Range on Protein: 858-911
Range on HMM: 9-58/176.0
DCPHEYINACYVDGYssdyQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQ
| .  |||| ...|.     .||||||. .|| ||. ......  ..|..|...
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteev

0043147 (Phosphotyrosine protein) phosphatases II 861-914 5.3e-11 38.0 In-house 5-58 (172) alignment
Range on Protein: 861-914
Range on HMM: 5-58/172.0
HEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYIF
. |||| |.|.|    ..||||||.. || ||| .....   .||..|...|. 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydp

0036282 (Phosphotyrosine protein) phosphatases II 861-913 2.1e-07 26.3 In-house 2-49 (174) alignment
Range on Protein: 861-913
Range on HMM: 2-49/174.0
HEYINACYVDGYSSDYQYIATQGPMSktlvdFWCLVWQERPPVIVMVTNHQYI
. |||| ..|..     .||.|||..     || ......  ..||... .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekel

0051429 (Phosphotyrosine protein) phosphatases II 862-916 1.8e-08 29.9 In-house 5-61 (272) alignment
Range on Protein: 862-916
Range on HMM: 5-61/272.0
EYINACYVDGYssdYQ------YIATQGPMSKTLVDFWCLvWQERPPVIVMVTNHQYIFIN
 |||| .|.||   ..      .....||.  |  ||| | ....  .||....  ..  .
gyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 864-910 4.3e-06 20.7 In-house 78-124 (301) alignment
Range on Protein: 864-910
Range on HMM: 78-124/301.0
INACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
| | ...      ..||||||...|  ||| .. |     |||....
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqk

0049260 (Phosphotyrosine protein) phosphatases II 868-914 2.8e-07 25.8 In-house 1-47 (152) alignment
Range on Protein: 868-914
Range on HMM: 1-47/152.0
YVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYIF
..|||   ...||||||.. || ||| ....    .|||.|..... 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelg

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 875-912 8.3e-07 23.4 In-house 4-41 (199) alignment
Range on Protein: 875-912
Range on HMM: 4-41/199.0
DYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQY
. .||||| |. .|. ||| .||.     |||| . | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqk

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 876-912 9.8e-07 23.1 In-house 4-40 (198) alignment
Range on Protein: 876-912
Range on HMM: 4-40/198.0
YQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQY
 .||||| |. .|| ||| .||.     |||| . | 
rryiatqhplretladfwqmvwetgsghivmvnddqk

subfamily_PTPRD_pd Subfamily PTPRD 908-1001 1.8e-15 51.6 In-house 266-360 (564) alignment
Range on Protein: 908-1001
Range on HMM: 266-360/564.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQFTVLQ-QVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGE
|..||||| .|.||.. ||||...| . .. . ||.|....|..||.|  |  |.  . ....| .    ..||.||| .. |. .. || |. .
teeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsai

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 908-959 3.5e-08 27.9 In-house 265-316 (318) alignment
Range on Protein: 908-959
Range on HMM: 265-316/318.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQFT
|..||.|| |..||....|.|..|. . || | .| |||||.|.|  . .| 
tedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 908-958 1.1e-07 26.2 In-house 268-318 (319) alignment
Range on Protein: 908-958
Range on HMM: 268-318/319.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQF
...||.|| .|.||.| .|.|.|.  . |  . .|.|....||.|| | .|
rpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref

subfamily_PTPRK_pd Subfamily PTPRK 908-958 8.2e-06 19.8 In-house 262-312 (314) alignment
Range on Protein: 908-958
Range on HMM: 262-312/314.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQF
|. ||.|| |..|| ..||.| |   . ...  . .. ||.|  .  .|.|
teeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef

0050432 (Phosphotyrosine protein) phosphatases II 912-1218 3.5e-74 245.2 In-house 1-307 (308) alignment
Range on Protein: 912-1218
Range on HMM: 1-307/308.0
YIFINDAVLEFVMCGNTQIDSWQARSMIGKLSE-QDPETGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLkGEHPDYINAVF
|..| ||.||......|.|  .  . .. .| .  .. .. ...||.|  |..|.  . | ..    .||||||.. .|| |. || | .|. ||||| .
yllildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsy

INGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS---GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIrL
..||  | ...||.. .|. ||  .||.|. . ||. ||||. . | ... |.||||..   ||...| ....| .|. ...|. ||.|..|...    .
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.r

SVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
 | ... |||   |   .|. .| ..|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||. ||. ....
tvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

VLAYLDSFQTYSN
.| || ...|. |
lleylklkltkln

0039614 (Phosphotyrosine protein) phosphatases II 913-1213 3e-65 215.9 In-house 2-292 (297) alignment
Range on Protein: 913-1213
Range on HMM: 2-292/297.0
IFINDAVLEFVMCGNTQIDSWQARsmigklseqDPETGQTGYEEQFTVLQQVTQkpDeVTHNIASQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYIN
... ||.||..... . .| .. .         .. .. |.....|  |....   |  ..    .||||||.. .|| |. || ||.     .. ||||
lplrdallesipiplsvldlllll.........ekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYin

AVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQqACYQYWPSSGSvVIGEYFIELENETRNNGYIERTFEIKNSNKTairLS
| ...||.  ...||..  |. .|  .||.|. . .||.||||. ..||..  |.||||..|. . |.....| ... ..||. ||.|..|....   . 
AsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges...rt

VVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
| ..| |.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|||  ||. ....
vthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda

VLAYLDSF
.| .|  .
llellkrk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 926-1216 4.5e-72 237.8 In-house 1-296 (298) alignment
Range on Protein: 926-1216
Range on HMM: 1-296/298.0
GNTQIDSWQARSMIGKLSEQDPETGQTGYEEQFTVLQQVTQKPDEVTHNIA--SQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKA
|||.|.. . . .. ||.. ..... |||...|  |..|... .| ....|  ..||.||| .. .. |  || |.     |. |||||.|...||...|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTaIRLSVVQYQITNWDSTG
||... |. .|  .||.|. ......||||   .||..  . .|||..|.   ||  ..| .. .   .| |..........  . .|.| . |.| . |
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkg

EVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTY
. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| .||  | ..|| .||||...
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

subfamily_PTPN6_pd Subfamily PTPN6 933-1215 6.1e-46 151.8 In-house 7-302 (306) alignment
Range on Protein: 933-1215
Range on HMM: 7-302/306.0
WQARSMIGKLSEQDPETGQTGYEEQFTVLQQVT-QKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEHPDYINAVFINGY--KEKKAFIIAESP
 . .. . .|.... .....|.||.|  |||   .|  . ..    .|| |||    || |. || ||       ||||| .|..   ...|..| ..  
keieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgc

MFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGS-VVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQ
. .|  .||.|. . | . |||. .|.|  .. |..|||.. .    |.. ..  .|.... || |.. ... .|     .|.||. ..|   |  |.|.
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg

TILMIMEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
..|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| .||  . ... .|... ..
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk

0045450 (Phosphotyrosine protein) phosphatases II 936-1210 3.1e-66 219.5 In-house 11-304 (307) alignment
Range on Protein: 936-1210
Range on HMM: 11-304/307.0
RSMIGKLSEQDPETGQTGYEEQFTVLQQVTQK-PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYINAVFI--------NGYKEKKAFI
. .. .|  ... .. ||....|  |..|| . ..| ..    .||||||.. .|| |. || |.      |. ||||| ..        .||. |..||
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

IAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSV-VIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGE
.. .|. .|  .||.|. . .||.||||... ||... |.||||..|.. ..|.....| .|.  .||. ||.|......|   . | ... |.|  .| 
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

VKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
 ......| ..||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||.  ||. .....| .|
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 938-1219 6.6e-158 519.1 In-house 6-287 (287) alignment
Range on Protein: 938-1219
Range on HMM: 6-287/287.0
MIGKLSEQDPETGQTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKM
..|.........|..|...|||||.||||..||||||||||||||||.||.|.||||||.||||||||||||||.||||||||||||||||||||||||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRT
|||||||||||||.|.| ....||||||.. |||.||| ||| ||..|.|||||..|.||.||.. ...|.|||||||||||.|..|||||...||||.|
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSNF
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||..|..|||.|||||.|||.|
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 938-1211 1.2e-20 68.5 In-house 8-288 (305) alignment
Range on Protein: 938-1211
Range on HMM: 8-288/305.0
MIGKLSEQDPETGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWK
 | |. ..  | | .|  ..|. .... .  . .     .|...|||  .    || || |.|  | .|| | ..    . | || ...|. .|  .|| 
qilkfvkrtlekgpaglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwy

MIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVI----GEYFIELENETRNNG--------YIERTFEIKnSNKTAIRLSVVQYQITNWDSTGevkNP
|  . .| || |||   |   . |..|..|    |.    ..  | .  |. ..          ...|  .      .  . | .|   .|   |    |
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvi.egpgekarkvthyhwidwpdrg...vp

QTILMIMEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
 . | |.| . ...  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| .||  . |..| |. 
aadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

0051299 (Phosphotyrosine protein) phosphatases II 941-1210 2.4e-71 235.9 In-house 16-286 (288) alignment
Range on Protein: 941-1210
Range on HMM: 16-286/288.0
KLSeqdpETGQTGYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWK
||      .|.||..|.|  |.... .  .... .  .|..|||.. .|| |. || |.     |. ||||| .|.||. |..||... |. ||  .||.
kll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSN---KTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEE
|. . ||. ||||. . ||... |.||||..||...|.....| .|. ...|. ||.|..| .   ..   . | ... |||   |   .|. .| ....
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

MYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||. ||. .....| ||
vrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 944-1217 1.1e-124 410.0 In-house 12-290 (290) alignment
Range on Protein: 944-1217
Range on HMM: 12-290/290.0
EQDPETGQTGYEEQFTVLQQvTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK--GEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKM
...  .|..|...||..|.. .... .||....|.|| .||.......|..|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRT
|....||.||||....| ... |.||||.|..  .||. |.| ||.  |.||||..|.||.|... . ||.|||||||||||.|.||||||...||||.|
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYS
|||||||||||||||||||||.||||||||||||||||||||||||||||||||||||| ||.||.|||| |||||.|||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 945-1212 3.5e-50 165.7 In-house 8-278 (281) alignment
Range on Protein: 945-1212
Range on HMM: 8-278/281.0
QDPETGQTGYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDD
|  .  ..|. |... |... .. .  |   | .|. ||| .     |. || .    . .. ||||| |..|||..|..|....|. ..  .||.|. .
qlsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

RNVTAIVMLCHENELKQQACYQYWPSSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAirLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQR
..|.||||. .| |  .  |..|||    .. .|.. .. ..|.... ||||.|......  .   .|.| . |.|  .|  .... .|   .|......
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresget..reveqlaytaWPdhGvPattkellefrkevlklte

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   ||||.||| . ..|| .|| 
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 945-1206 1.9e-49 163.7 In-house 27-287 (319) alignment
Range on Protein: 945-1206
Range on HMM: 27-287/319.0
QDPETGQTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDD
.| .  .| .| .|  . ... .  . |.    ||||||| .. |. |. .| |.   | |  ||||| |..||. |. .| |  |. ||  .||.|| .
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

RNVTAIVMLChenelkQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEE-MYRTQR
 |...||.|       .. | ||||  . .  ... ....  .  . |. | .|. .  |     .. |. .  |   |  . |  ......   . |..
yncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
......||||||  |||. .. .  . ... | |  .||.....  | |..  || ..||  |   .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

0047943 (Phosphotyrosine protein) phosphatases II 946-1210 1.2e-69 230.1 In-house 6-272 (273) alignment
Range on Protein: 946-1210
Range on HMM: 6-272/273.0
DPETGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
.. .| |...|.|  |....  . . .. .  .||||||.. .|| |. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCHENELKQQACYQYWPSSG---SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAiRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-
||||. . ||... |.||||..|   |.. |.....| .|. ...|. ||.|..|..     . | ... |.|   |   ... .| ..|.. .....  
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
.|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||. ||. .....| ||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPN9_pd Subfamily PTPN9 947-1209 3e-41 136.4 In-house 11-289 (297) alignment
Range on Protein: 947-1209
Range on HMM: 11-289/297.0
PETGQTGYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |.|. |  .... ... . .  ....     |  ||| |  |  |. || |.     |. ||||| |..|||.||||| .  |. .| ..||.|. ...
kekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

VTAIVMLCHENELKQQACYQYWP--SSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQR-
|  |||  .  | ..  | ||||  .  |   |.. ..  .   .. | .|..||||...  .| .|. .|.. |   |  .. ...| ..|.. ..|  
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaaslldvlekvrekqal

--------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
        ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||  |||   . || |
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_PTPN23_pd Subfamily PTPN23 948-1210 3.8e-49 162.0 In-house 11-280 (288) alignment
Range on Protein: 948-1210
Range on HMM: 11-280/288.0
ETGQTGYEEQFTVLQQVTQKP-DEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTA
  |.|. ...|  |.|  .|   . .  ||  . .||||.  || |. || |.|.. ||||| |...       ||.. .|. .|.  ||.|. .. .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEM---YRTQRK
|||| ...||... . .|||..   .|. |.. . |..... . ..||.....  .. |.. ||.  |.|.| . |  . |.|.| ...|.   |.....
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavk.svshlqltsWpelGvPasPetllqfldevesayeavqr

RGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
. .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||...|..   ..|| . 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_PTPN12_pd Subfamily PTPN12 948-1210 9.6e-48 157.5 In-house 4-277 (290) alignment
Range on Protein: 948-1210
Range on HMM: 4-277/290.0
ETGQTGYEEQFTVLQQVTQKP--DE---VTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
..|.  ....|. |.....|   ..    ..  ...|. |||    || |. || |.     |. ||||| ||.| ..|...| | .|. .|  .||.||
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

DDRNVTAIVMLCHENELKQQACYQYWPSSGSVV--IGEYFIELENETRNN-GYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEVKNPQTILMIMEEMy
.. ||. .||.|.| ||... | .|||..|     .||. ..||.| . . ... ||.........    .| |.. |.|   |  ......| ..|.. 
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielv.

RTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
|. ... .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||  ||| . . |. ..
relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 949-1215 4.1e-72 237.9 In-house 19-288 (305) alignment
Range on Protein: 949-1215
Range on HMM: 19-288/305.0
TGQTGYEEQFTVLQQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. ..|.|.|.  |..  ... .|... |...|....... |..| ...  | ...  ||||| ...|||.||..|.| .|. || ..||..| .  |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCHENELKQQACYQYWPSSGSV--VIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT
|||..  | ... |.|||| | .    .||. .||..|.  ..|||| ..| . ..     .|.|||.|.|   | .. . ..| ..... ..|.|  ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
...||||..|||. .|.|    ....|.|.|.|||.|||  | .... |||  ||  . ...  .. ...|
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt

0036941 (Phosphotyrosine protein) phosphatases II 949-1215 3.1e-68 225.6 In-house 10-282 (297) alignment
Range on Protein: 949-1215
Range on HMM: 10-282/297.0
TGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
.. ......|  |...   . . .. .  .|..|||.. .|| |. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||| |||
lflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LCHENELKQQACYQYWPSS--GSVVIGEYFIELENETR--NNGYIERTFEIKNSnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GN
|. . ||  . |.||||.   .|.. |.....| ...   ...|. ||.|...  ..   . | ....|.|.  |   .|...| ..|.. . ...  ..
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
. ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||. ||. .....| .| .. |
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 949-1215 1.5e-59 196.6 In-house 20-288 (319) alignment
Range on Protein: 949-1215
Range on HMM: 20-288/319.0
TGQTGYEEQFTVLQQVTQKpdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
||.|. |..|  |.. ...  ....    .||.||| .. |. |. || |.     |  ||||| ||.||.|...|| . .|. ||  .||.|. .... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

AIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT
 .|||.. .|  .  . .|||.   .. |.. ..||.| . ..|| | ..... .      .|...| |.|   .  .. ...| ..... ....|  . 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
 ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.  ||. | ...|.......|
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 949-1216 2.2e-52 172.9 In-house 18-287 (288) alignment
Range on Protein: 949-1216
Range on HMM: 18-287/288.0
TGQTGYEEQFTVLQQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
...||..|.. .| .. .| ..||    ..|..|||  . || |  || ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... .....
rnrtgfseeynsLaal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

AIVMLCHENELKQQACYQYWPSSGS-VVIGEYFIELENETRNNGYIERTFEIKnsnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRgN
 |||| .  |  .. | .|||...  .  |.  ..| ..   . ...|.....   |.  .| . ||| . |  .|  .. . .| ... .  .. .   
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL--AYLDSFQTY
  |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||..||| | ...|  .. |. ...
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgvaev

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 950-1218 3.2e-64 212.0 In-house 18-288 (318) alignment
Range on Protein: 950-1218
Range on HMM: 18-288/318.0
GQTGYEEQFTVLQQVTQKPDEvTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
|.. ..|..  |....... . .. . . || ||| .  |. |. || |.     |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| . 
Gelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTS
|||| .|.|  .. . .||||.||  .|.  .||..|.. . |. |.|....... . |  | ||..|.|  .|  ... ..| .. .  ..|.| |.. 
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
||||||  |||  .|.|  . ... | |...||||. |  | |..  |||  ||| | ...| .| |..|. .
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

0043336 (Phosphotyrosine protein) phosphatases II 950-1209 1.6e-63 210.1 In-house 18-276 (278) alignment
Range on Protein: 950-1209
Range on HMM: 18-276/278.0
GQTGYEEQFTVLQQVTQkpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
..|.....|  |....   |. .. .  .||||||.. .|| |. || |. .      ||||| ...||. ...||..  |. .|  .||.|. . .|| 
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLCHENELKQQACYQYWPsSGSVVIGEYFIELENETRNNGYIERTFEIKNsNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTS
||||. . ||... |.|||| .||...|.....| .|. ...|. ||.|..| ...   . |..|. ..|   |   .....| ..... . ..   |. 
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngp

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.|||  ||. .....| |
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_PTPRG_pd Subfamily PTPRG 950-1214 1.1e-52 174.0 In-house 17-291 (563) alignment
Range on Protein: 950-1214
Range on HMM: 17-291/563.0
GQTGYEEQFT-VLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
|..|..|.|  . .....|  ...|  . .|| ||| .. .. |. || |.   |..   ||||| .|.||. .||||..  |. .|.  ||.|| ..||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNS-----NKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQ
. |||.   .| ... | .|||. .|. .|.  . |..| .   | .||. |||      ...   . | ||. |.|  .|  . .   |. ..   ...
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

RKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQ
..     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||  ||  . ...|  . | .
ka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

subfamily_PTPRB_pd Subfamily PTPRB 950-1212 1.9e-49 163.3 In-house 23-287 (293) alignment
Range on Protein: 950-1212
Range on HMM: 23-287/293.0
GQTGYEEQFTVLQQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
 .... |..  |..| ..  .|. . ...|..||| |. || |. || |    . .. ||||| .|.||. .. || .  |. .|  .||.|. ......
sdlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLCHENELKQQACYQYWPSS-GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTairLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQ-RKRGN
|||| .  |  .. | .|||.   .|. |.  ..| .|.. . .. |...|......    .| ||. | |   |  ....|.| ..... ... ..  .
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekee...rkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||..||  | | ||..| .
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 950-1208 5.4e-30 99.2 In-house 18-277 (439) alignment
Range on Protein: 950-1208
Range on HMM: 18-277/439.0
GQTGYEEQFTVLQQVtqKPD-EVTHNIASQ--NKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |  ..| |  .. .  .|| ..  ..|.|  .. |||  .  . |  || |       |  |||| .|.|| ..| .| .. |  .|. .||... ...
kqeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

VTAIVMLCHENElkqqaCYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR
.. ||||.   |      |.||||.. |. |.  .  . .     |. | | . |    |    .|.|.. . |       .   .|  .  .  .. |.
tvtivmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLA
    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  | . || 
eygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 951-1207 1.1e-66 219.7 In-house 5-263 (283) alignment
Range on Protein: 951-1207
Range on HMM: 5-263/283.0
QTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
..... .. ||....  . ... . |..|| |||  . .| |..|| || | .||||||||     ||..| .||| ||. .| ..||||. |...||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKnPQTILMIMEEMYRTQRKRGNTSIV
|| .  | ....| ||||. ||.  ||. . |..|| .| .| . . ..... .   | .  ||. .| . ||   .   |. .. .   |..  .. ||
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskkgPiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
|||| ..||.|.|.||...... .|| |.|||.|.|  | |... |||  ||  . ..||
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 951-1218 7.2e-65 213.6 In-house 14-301 (301) alignment
Range on Protein: 951-1218
Range on HMM: 14-301/301.0
QTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
....|||.. |.....|. .|... . .. ....... .. ..  .  |      . .|||| .|.||.|||.||.|..|| .| ..||..| .  ...|
snkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLCHENELKQQACYQYWPSSGSVVIGEYFI--ELENET-----------------RNNGYIERTFEIKNSNktaIRLSVVQYQITNWDSTGEVKNPQTI
||.. ..| ... |.||||.|      ....  .| ||.                  |||||||.|..|...      .|.|.|.|.|   | |..|.|.
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtv

LMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
|......  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  ||  | ...  ||   .||.|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Ptp69D_pd Subfamily Ptp69D 951-1211 1.1e-53 177.3 In-house 21-287 (307) alignment
Range on Protein: 951-1211
Range on HMM: 21-287/307.0
QTGYEEQFTVLQQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. |... .  |..  . . . .      |. |||. .  . |..|| ||     |. ||||| ||.|||||| ||.|  |. .|. .||.|| . .|| |
dfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTA----IRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRg
|||  ..| ... | .|||    |  |.  ..| .| . . ||.|.... . ....     .  ||||. |.|. .   . ....| ..|...  ...  
vmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
.. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||   ||. . . .| | .
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 951-1208 5.4e-44 145.6 In-house 22-286 (325) alignment
Range on Protein: 951-1208
Range on HMM: 22-286/325.0
QTGYEEQFTVLQQVTQKpdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAI
| |.  .| .|  .  .    .     .||.|||    .. |. || |.      . ||||| ... .|.|. |. | .|. .|  ..|... | . ...
qdgfahefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csv

VMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIrLSVVQYQITNWDSTGEVKNPQTILMIMEEMYR---TQ--R
|..  | .|... | .|||     |.  |   ..|        |. | ...|. .|    .|| |.|.  ||  |  | | |.. |.. .     .    
vvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGet.rsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLA
 .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| ||  | . .  
tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 952-1205 5e-43 142.0 In-house 6-254 (267) alignment
Range on Protein: 952-1205
Range on HMM: 6-254/267.0
TGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
. .|..|  .......   ..  ||..|...||  . || |. ||.|. .  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| .
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

ENelkQQACYQYWPSS-G-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYqiTNWDSTGEVKnpQTILMIMEEMYRTQRKRGNTSIVVH
     ..   ..||   | .    .  .|   |  .| |   |.|.|  |..|  ...  |   .|.   . |    .  ..  . . | . ||  .||.
vf...tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyy..kkwnintnnk..pylkplfgilaknqlengnrPlvva

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
||| ||||  |  . . ... ||||| |.|. |.  | |..| |.|  .|  | ..
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel

0040438 (Phosphotyrosine protein) phosphatases II 953-1212 1e-66 220.7 In-house 19-278 (317) alignment
Range on Protein: 953-1212
Range on HMM: 19-278/317.0
GYEEQFTVLQQVtqKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
. .|.|  |...  |.|. .. .  .||||||.. .|| |. || |. .      ||||| ...|...|..||.. .|. ||  .||.|. . .|| |||
alleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVV
|... ||... |.||||. .....|.....| .|. ..|.. ||.|.... ..   . | ... |.|.  |  ..|...| ..|.. . .. .... ..|
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlV

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
|||. |||...|.|| . .. ...|| .||....|  | |.||.|||  ||. .....| ||  
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

subfamily_egg_pd Subfamily egg 953-1210 4.6e-19 63.2 In-house 15-270 (307) alignment
Range on Protein: 953-1210
Range on HMM: 15-270/307.0
GYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
..| .. ||......   .|. ... |..| || .    |  || |.   | .  |.| |  ..|      ||.|..|. ||  .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCHENELkqQACYQYWPSSG--SVVI--GEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQiTNWDSTGEVKNPQTILmimeemyRTQRKRgNT
|    |   . |  ||| .   |.|.  | . ||  .  ..   . |  ..|        . .  .|  ... ...|  |  .|       |  |.   .
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvl.......rklrnl.sk

SIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVTQYEGICQIVLAYL
 .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..| .|  . ..|| ..
pvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 954-1210 5.1e-26 86.4 In-house 18-277 (307) alignment
Range on Protein: 954-1210
Range on HMM: 18-277/307.0
YEEQFTVLQQvtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK--GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
  ..|.|| .  ..|. || .  | | |||| ..    |. |. .|  |   ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.
lvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

ENELKQQACYQYWPSSGS--VVIGE--YFIELENET-----RNNGYIERT-FEIKNSNKTairLSVVQYQITNWDSTGevkNPQTILMIMEEMYRTqRKR
  || .  | ||||       | ||    | ..|        .. .|. | .... ..|.    .. ..| .||   |    ||. |  .. .  . |  
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqks...rtiqhlqwenwpdrg...vpqinltainlleav.ryd

gNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
 .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  ||  . ...| |.
.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 954-1210 4.9e-19 63.0 In-house 29-290 (310) alignment
Range on Protein: 954-1210
Range on HMM: 29-290/310.0
YEEQFTVLQqvTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
   |.  |.  ...   .|..   ..  ||| .. .  |. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    .|..||
lvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

HENELKQQACYQYWPSSGSVVIgEYFIELENETRNN-----GYIERTFEIKNS--NKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGN
.  |  .  |  |||| |        | . | .          .  ||   |   ..    |  .. .. .|    .   |.     . .   .| . | 
kvgeegrpkcvgywpslgvtet.ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgp

tsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
   |||||  ..|  . .|   .|.| .    .|. .|    . ..   .||  ||  | .. ... 
..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa

0046845 (Phosphotyrosine protein) phosphatases II 955-1218 1.6e-68 226.4 In-house 3-282 (284) alignment
Range on Protein: 955-1218
Range on HMM: 3-282/284.0
EEQFTVLQQVTQKPD-EVTHNIASQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNV
||.|  |...| |.  .... .. .|..|||....|| |. || ||      |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TAIVMLCHENELKQQACYQYWPSSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRK-R
. ||||. . | ... |.||||..| ....|.....| .|. ...|. ||.|..| . |   . | ....|.|   |   .|. .| ..... . ...  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
|.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. ||. .....| || .. |. .
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle

DSPc_SM00195 955-1210 2.4e-64 212.6 In-house 3-262 (263) alignment
Range on Protein: 955-1210
Range on HMM: 3-262/263.0
EEQFTVLQQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |..  |.|... ..||.|||....|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENELKQQACYQYWPSS--GSVVIGEYFIELENETRNN-GYIERTFEIKNSNKtAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIV
 |.| ... |..|||..  |. ..|.. ..| ...  .  .| ||.|... .|     .| |||..||   |  .... .| ...... ....  .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||  |....|.|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 955-1210 2.4e-64 212.6 In-house 3-262 (263) alignment
Range on Protein: 955-1210
Range on HMM: 3-262/263.0
EEQFTVLQQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |..  |.|... ..||.|||....|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENELKQQACYQYWPSS--GSVVIGEYFIELENETRNN-GYIERTFEIKNSNKtAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIV
 |.| ... |..|||..  |. ..|.. ..| ...  .  .| ||.|... .|     .| |||..||   |  .... .| ...... ....  .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||  |....|.|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN13_pd Subfamily PTPN13 955-1212 1.6e-39 130.8 In-house 14-271 (273) alignment
Range on Protein: 955-1212
Range on HMM: 14-271/273.0
EEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
.|.|. |...  . |...     .||||||  . || |. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

NELKQQACYQYWPSSGS--VVIG-EYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVH
 | ..  | .|||.| .  ...   . .||.. .. .|.  |....|.|. .. |  |.. . ..|   |  .... .| .. |. | |.   .. ||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesr.evahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
||  .||| .. .  . ..  . .  .|| ..... | |. | |||  ||  . ...|  | |
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 955-1210 1e-18 61.8 In-house 29-285 (302) alignment
Range on Protein: 955-1210
Range on HMM: 29-285/302.0
EEQFTVLQQVTQKPDEvtHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCH
...|  ....  . ..   ..  .| .||.|...  .|. .| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  
kkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg

ENELKQqACYQYWP-SSGS-VVIGEYFIELEN-ETRNNGYIERTFEIKNSNKTAIRLSVVqYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVV
|.|||. .  ...|  ||. .  |. |.     |  ..   . . |.   . .   |. | | .||| ..   ..  ..   .....  .   .. ..|.
eeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv.yvltnWkqkkvpvkyaeliktaakvfakk.ikadentvi

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
     .|| ..| ..|....| ...    . ...|| | |.| .|....||  .  ..| |.
vSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_PTPRN_pd Subfamily PTPRN 956-1206 5.8e-36 118.7 In-house 33-288 (297) alignment
Range on Protein: 956-1206
Range on HMM: 33-288/297.0
EQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGE----HPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
...  | .  ..|   .   | .| .||||...|| |. || || |    . ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

HENELKQQACYQYWPSSGSVVIGEYFIELENET-RNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGnTSIVVH
. .|   ..|..|||  || | . | ..|  |    . |. |.| .|| ...  | .| |.    | ..|   .....|     . .. | |  ..||||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvh

CSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
||| .||. ....    .|.  |    ||.   |.  | |.|| |.|  |.| . . |
csdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_ptpA1_pd Subfamily ptpA1 956-1170 5.2e-20 66.5 In-house 25-256 (418) alignment
Range on Protein: 956-1170
Range on HMM: 25-256/418.0
EQFTVLQQvTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
|.| .|.. .  | | .     .|  ||| |. || .  || ||     |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .
eefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsr

ENELKQQACYQYWPS-----------SGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRK
|.|  .  | .|||             |  |.| | .|| .  ..      | .|. . .   |  . |||   |         | .  ..  .   | .
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr.ditqyqyegwpdhnipdhtqpfrqllhsitnrqnq

-----RGNTSIVVHCSDTVGRSAMFCAAATTINKC
       |  |.||||  |||.  ||.|   ..| 
iipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_CG42327_pd Subfamily CG42327 956-1134 6.4e-18 59.5 In-house 9-190 (319) alignment
Range on Protein: 956-1134
Range on HMM: 9-190/319.0
EQFTVLQQVTQKPDevthNIASQNKDKNRSTQF--LPPDNYRVPLKGEHP--DYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLC
|.|  | |.  . |    ..    |||.|  .   ||. .  .. .|...   |..| .. ||.. .. .| |. .. ... .||... ...   || |.
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

HENELKQQACYQYWPSS----GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQItNWDSTGEVKNPQTILMIMEEM
   ||  . | .|.|..    .  . |.. . | .   .. |.  |. .|. .|   |  .  |   .|  ..   ...... .. |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleaevPaeeaaliamllev

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 959-1085 1.1e-07 25.5 In-house 65-171 (349) alignment
Range on Protein: 959-1085
Range on HMM: 65-171/349.0
TVLQQVTQKPDEVTHNiASQNKdknrstqflppdnyrvplKGEHPDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELK
 .|..  . .  . .   |. .                   |   ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|| 
vklkkslksskvikas.tsesd..................sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

QQACYQYWPSSGsvvIGEYFIELENETRN
 . |..||         .. . | |   .
lekcdiywqels...ysnitvklqnssly

subfamily_PTPN1_pd Subfamily PTPN1 961-1200 4.9e-36 118.9 In-house 12-261 (290) alignment
Range on Protein: 961-1200
Range on HMM: 12-261/290.0
LQQVTQKPDEVTHN--IASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQ
....... ......     .|...||     | |  |. |. .. ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  | .|.
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

ACYQYWPSSGS---VVIG--EYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQR-KRGNTSIVVHCSD
 |.||||.  .   ...   .. ..| .| |.. |. |..|..| .    | .....  | |   |  . |.. |  . .. ..   ..     |.||| 
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetr.eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

TVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYE
 .|||  || . | .    | .    .|. .||   | .. | .||  | .
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr

subfamily_PTPN14_pd Subfamily PTPN14 961-1211 5.7e-32 105.9 In-house 29-297 (300) alignment
Range on Protein: 961-1211
Range on HMM: 29-297/300.0
LQQVTQKPDEVTHNI--ASQNKDKNRSTQFLPPDNYRVPL---KGEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEN
 .....|  . . .     .|..|||  ..|| .. || |   | .. .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| .|.
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

ELKQQACYQYWPSS----GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT-----
|  .. ...|.|..     .|  |.. .  .  .  . .| .....|       | .|.  | |.|   |  ..... |  .||.   .||  ..     
edgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer.tvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

---SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
    ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||..||. . .... ||.
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 961-1198 7.2e-27 88.9 In-house 32-269 (301) alignment
Range on Protein: 961-1198
Range on HMM: 32-269/301.0
LQQVTQKPDEVTHNIASQNKDKNRSTQF--LPPDNYRVPLKGEHpDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQ
..  | . |..|.  |  .|||.|  .    |    .|  .|.    | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... | ...
vnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkveklee

ACYQYWPSS--GSVVIGEYFIELENET--RNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEeMYrtqrKRGNTSIVVHCSDTV
 | .| |..   .. || . |...|.    |.  ..||.|...| .     .|. || ..|   |  |    .  .|| .     |. .  ||||||. .
kceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lv....kksekPivvhcsaGi

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQ
|||  | ..    .. ...  |.. . ||  | ..  .|||..|
Grsvafigteylareveadptieltealkhlrehrwngvqtnsq

0045098 (Phosphotyrosine protein) phosphatases II 962-1210 4e-61 202.2 In-house 16-272 (278) alignment
Range on Protein: 962-1210
Range on HMM: 16-272/278.0
QQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPlkgehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACY
. ..  |.|.|...   |.|||| ...|| |. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... ||... |.
llllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNS---NKTAIRLSVVQYQITNWDSTGEVKNP--QTILMIMEEMYRTQR------------KRGNT
||||..||...|.....|..|.... |. ||... |     ..   . | ......|.  |   .|  . .| ..|.. . ..              ...
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

SIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVTQYEGICQIVLAYL
 ..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||.  ||. ... .| .|
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 964-1202 3.9e-10 33.8 In-house 32-271 (303) alignment
Range on Protein: 964-1202
Range on HMM: 32-271/303.0
VTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKgeHPDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQY
|.  | .|..|   .| |||| .. .  |  .| |      || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| ..      
vsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSSGSVV-IGEYFIELENET---RNNGYIERTFEIKNSNKTAIrLSVVQYQITNWDSTGEVKNPQTILMIMEeMYRTQRKRGNTSIVVHCS-DTVGRSA
.|     . . | .| . .       .|.  .   . | .  .. | | .|.    .|     .|. .  | . .    ||  ...  |. |   .||. 
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksf.lhvhhykawphnsipsdgspkfvkqiwq.lqsvlrkysdstptvymslsgcgrag

MFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGI
 |.   |.     . .  .|. ..|.  |  .  .|| ..|.  .
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 966-1209 1.8e-27 90.8 In-house 34-235 (392) alignment
Range on Protein: 966-1209
Range on HMM: 34-235/392.0
QKPDEVTHniASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKqqacy
  |. |..     |. |||  . || |. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. . .|       
iypqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

qywpssgsvvigeyfielenetrnngyiertfeiknsnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtQRKRGNTS--IVVHCSDTVGRSAM
                                      |     .| |...|.|   .  |   ..| ...|.   . . |. .  ...|||  |||...
......................................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgv

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
  .  . . ..|.  ..|||...   | ..|  |||  ||  |   ||  
visidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 967-1127 2.4e-13 44.3 In-house 84-242 (244) alignment
Range on Protein: 967-1127
Range on HMM: 84-242/244.0
KPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK-GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKqqacyQYW
 |  .   .  .|  |||    || |  ||||  |     |||| |.        .|... |. .|. .||||. .| |  .|.|   .|       .||
dpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eyw

PSSGSVVIGEYFIELENETRNNG--YIERTFEIKnSNKTAIRLSVVQYQITNWDSTGEVKNPQTI
| |  .   |  | .    |..        .||. |.      ..  .||.|| | |   |   |
pdseplewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdgttpndhfi

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 968-1206 1.1e-48 161.2 In-house 14-251 (284) alignment
Range on Protein: 968-1206
Range on HMM: 14-251/284.0
PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenelkQQACYQY
  . |.    ||||||| .. |. |. .| |.   | |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCA
||  . .  ... ....  .  . |. | .|. .  |     .. |. .  |   |  . |  ......   . |........||||||  |||. .. .
wplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
  . ... | |  .||.....  | |..  || ..||  |   .
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_CG7180_pd Subfamily CG7180 968-1210 1.3e-44 147.1 In-house 31-290 (296) alignment
Range on Protein: 968-1210
Range on HMM: 31-290/296.0
PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQqACYQY
 ..  ... ..|..|||  . .|.|. || |.   || . ||||||.....  ||..|. | |. .|  .||... |... |.|.|... . ..  . .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPSSGSVVIGEYFIELENETRNNGYIERTFEIKNS------N----KTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRG-----NTSIVV
||  .    || |.|. .|        ||| ..        .    |.  |. | ..|.| |..  .|    . |. . .. |. |..      .  .||
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRi.vklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|..|  | ...| ..
vssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 968-1209 1.1e-18 62.2 In-house 24-269 (285) alignment
Range on Protein: 968-1209
Range on HMM: 24-269/285.0
PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS
| ..|.     | | || ..    .. || ||    ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   . |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

S-GSVV-IGEYFIELEN--ETRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTilMImeEMYRTQRK--RGNTSIVVHCSDTVGRSAM
  | || .|.| | | .  |    | |  .. . |..  ..  | . . |.  |      .. .   ||  |.|.  .|    .. |.||||  |||.| 
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarp..mi..elykwvkkvnpkekpicvhcsagvgrtat

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
|     .  .   .  |.......  |  .  .||.  |.  .  ... |
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 968-1195 1.2e-12 42.5 In-house 18-206 (255) alignment
Range on Protein: 968-1195
Range on HMM: 18-206/255.0
PDEVTHNIASQNKDKNRSTQFLppdnyrvplkgehpdyinavfingykekkafiiaespmfnTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS
 |. |.... ... |..... |                                        |  .|...|   . . .||||  .| ... | .|.|  
edvctehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfple

--GSVVIGEYFIELENetRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTILMIMeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAA
  .  .. .  .   .    .  . || ||            |  |. . |      .... || |.    .  |.    |.|||||  .|||| |  | 
kdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlae

TTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQT
           . .| . .|  ..|.  | .......|
lvyqkmirsldttet.veldylslleelrskrkraiht

subfamily_PTPRD_pd Subfamily PTPRD 970-1216 2.6e-66 219.5 In-house 39-287 (564) alignment
Range on Protein: 970-1216
Range on HMM: 39-287/564.0
EVTHNIASQNKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP
....  ...|| |||  . .. |. || |.     |  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .| ... | .|||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

SSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAAT
..|.  .||. ..||.|.. . |. |||..|....   |  | |.. |.| ..|  ......| ..... ... ....  ||||||  |||. .|..   
ekgtetygeltVtleeeeeladyeirtfklkkkkssesr.eVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivida

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTY
 ... |.|...|..|..|  | |..  ||| .||  | ...| .|....| 
mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

subfamily_PTPN3_pd Subfamily PTPN3 970-1209 1.9e-42 140.1 In-house 32-274 (280) alignment
Range on Protein: 970-1209
Range on HMM: 32-274/280.0
EVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP
....   ..| .|||    || |. || || .. ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |  .. |.||||
aisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

SSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
... ..  ||. ...|.| ... |. | . .|.....  | ...| | ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  
etedeleygefsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlille

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
|.. .  ..  . . ....  | |.   |||..||. .|. .|. 
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 970-1050 6.4e-08 26.5 In-house 37-117 (347) alignment
Range on Protein: 970-1050
Range on HMM: 37-117/347.0
EVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
....| . . | .. .   | |.. .     .   ||||  |.  . .| .|... |. .| |.||||.   .|| .| . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

0040439 (Phosphotyrosine protein) phosphatases II 971-1210 2.7e-58 192.8 In-house 3-246 (249) alignment
Range on Protein: 971-1210
Range on HMM: 3-246/249.0
VTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS
... .   ||||||.. .||.|. || |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... ||... |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

SGSVVIGEYFIELENETRNNGYIERTFEIKNSnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAAT
.||...|.....| ... ...|. ||.|..|. ..   . | ..|.|.|  .|  ......| ..|..   ...   .. ..||||. |||...|.|| .
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
 ..  ..|. .|.....|  | |.||.||.  ||. .....| .|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 971-1215 9.6e-48 157.8 In-house 40-289 (297) alignment
Range on Protein: 971-1215
Range on HMM: 40-289/297.0
VTHNIASQNK---DKNRSTQFLPPDNYRVPLKG--EH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQqACYQY
.. .  ...|   .|.| .  || |  || |.   ..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..|| ..  | .|
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNkTAIRLSVVQYQITNWDSTGEVK--NPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFC
|. .|..  |.  ..|.  .. .|.|.|..|..... .  |  | ||| ..| .  . .  . ...| ...|.  .  .. .. ..|||.  ||| ....
WsdkgvttfGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
.    . . | |  .|.|...|  | ..|  |||  ||. . ..|| .| | .|
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 973-1213 1.1e-27 91.5 In-house 48-286 (290) alignment
Range on Protein: 973-1213
Range on HMM: 48-286/290.0
HNIASQNK--DKNRSTQFLPPDNYRVPLK-GEHPDYINAVFINGYKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS-G
 .|  .|    |||  .    |  || || | . ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||   |  .  | ||.|   |
rkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

S-VVIGEYFIELE-NETRNNGYIERTFEIKNSNKTaIRLSVVQYQITNWDSTGeVKNpqTILMIMEEMYrTQRKRgNTSIVVHCSDTVGRSAMFCAAATT
  . .||. .    ......  | .|. ... ..      .  ..|  |     | .  . | ..  .. . ||  .  .|||||  .||.  | |  ..
evltfGeitvlcseeddkdaniikktlsvrdkdsG.kehklkhlkikswpdks.val..stlallrtlr.ilrka.sGpvvvhcsaGiGrtGtfvaievg

InKCKTEG-VIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSF
. .. ..|  .|. .. .. |  . .|||  .||  . .|.| .  .|
l.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 974-1024 4e-06 20.9 In-house 43-94 (95) alignment
Range on Protein: 974-1024
Range on HMM: 43-94/95.0
NIASQNKDKNRSTQFLPPDNYRVPLKGE-HPDYINAVFINGYKEKKAFIIAE
  .  |  |||  . .| |  || |      |||||.|..||  |...| |.
gsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq

0037934 (Phosphotyrosine protein) phosphatases II 975-1209 1.5e-53 177.2 In-house 6-241 (243) alignment
Range on Protein: 975-1209
Range on HMM: 6-241/243.0
IASQNKDKNRSTQFLPPDNYRVPLKGehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENELKQQACYQYWPssGSV
.  .|..||| . .|| |. || |.|   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... ||... |.||||  |.|
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev

VIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAA
..|.....| .|.  ..|. ||....| . .   . |..|. ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....||
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

ATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVTQYEGICQIVLAY
 . . ..   | .|.....|  | |.|| .|||  ||. . ...| .
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 975-1211 9e-44 144.6 In-house 40-278 (315) alignment
Range on Protein: 975-1211
Range on HMM: 40-278/315.0
IASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS--SG
  ..|  |||    || |. || |    .  . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|  .  | ||||   . 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
||  |.. .|| .   . . . | . ...|...     | |.| |.|   |  |.  ..| .. |.    ... . |..||||  |||. .....   ..
svefGsikvellsleadtdgvarklvtrkseesr...tvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

KCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
. | . ..|||...|  | ..|  |||  .|  | ..|| .| 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 975-1211 2.8e-38 126.5 In-house 16-265 (270) alignment
Range on Protein: 975-1211
Range on HMM: 16-265/270.0
IASQNKDKNRSTQFLPPDNYRVPLKGEHPD----YINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGS
 | ..|  ||... ||  . || |. .. |    |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|  .. | .|||..  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

V--VIGEYFIEL--ENETRNNGYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEVKNP------QTILMIMEEMYRTQRKRGN-TSIVVHCSDTVGRSA
    . . .|.   ..|....||| .  ..... ..     .| .. ..|   | ....      . .| ..... |....  . . ..||||. |||. 
ekvkledgkikvlalseekeegyiltrlrleekgeer...rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
.. |  ....  .... .|| ....  | ...  ||.. ||| . . |. | .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

0042113 (Phosphotyrosine protein) phosphatases II 976-1210 2e-59 196.3 In-house 6-243 (245) alignment
Range on Protein: 976-1210
Range on HMM: 6-243/245.0
ASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVV
   ||||||....|| |. || |. .      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | ||... |.||||...|..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

IGEYFIELENETRNNGYIERTFEIKNsNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
.|.....| .|. ...|. ||.|..| ...   . |..|. ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  .
ygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
.|. .......|  | |.||.|||  ||. . ...| .|
kelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 976-1207 4.8e-46 152.1 In-house 46-276 (315) alignment
Range on Protein: 976-1207
Range on HMM: 46-276/315.0
ASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSgSVV
 ..||.|||  . .. |. || |    . .| ||.|| ||.||. |. .| |..|  .. ..||... . ... ||||    | ... . .|||    |.
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kvi

IGEYFIELENETRNNGYIERTFeiKNSNKTAIRlSVVQYQITNWDsTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 |.. . . .|  |. |  ||.      .  ||  |||...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... .
yGkitvtrkseevnteytvrtl..svvfgdnir.evvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
.| .|||.....  | .. . ||.. ||. | ...|
aenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 977-1218 1.9e-59 195.9 In-house 7-250 (250) alignment
Range on Protein: 977-1218
Range on HMM: 7-250/250.0
SQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQaCYQYWPSSGSVVI
 |||.||| ..... |. || |. |.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   .| ... . ||||  ..   
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
|.  ..| ..     |. |.. . . .|.  |  |.|.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.
Gdvtvsllskeefadytkrklklskakkader.ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
| |.|||.|.|  |...|..|.. .||  . .|.| .|||.. |..
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar

subfamily_PTPRA_pd Subfamily PTPRA 977-1209 6.2e-58 191.2 In-house 56-294 (330) alignment
Range on Protein: 977-1209
Range on HMM: 56-294/330.0
SQNKDKNRSTQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVI
 .||.|||  . || |  || |    | |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .| |.. |.||||. |.|  
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty

GEYFIELENETRNNGYIERTFEIKN----SNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTIN
|.  .|.|.||  . |  | | ...    ... . || | |.  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ..
Gnirvevedetvlvdytvrkflvqqlpdatrekksrl.vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

KCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
. |.|...|||...|. | |.|  |||  ||| | ...| |
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPRK_pd Subfamily PTPRK 977-1207 1.2e-49 163.9 In-house 41-274 (314) alignment
Range on Protein: 977-1207
Range on HMM: 41-274/314.0
SQNKDKNRSTQFLPPDNYRVPL---KGE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVvI
 .|..||||.. |..|. || |   .|. . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  |  .  |..|||  ..|  
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.y

GEYFIELENETRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCK
|.  .|| . . .. .. |.| ......    .  | |.| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  .
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmie

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
.|||.|||.. |. | .|.  |.|  ||  | ...|
regvvdvfnavktlrsrkvnmveteeqykfiydvil

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 977-1211 4.7e-44 145.5 In-house 26-269 (274) alignment
Range on Protein: 977-1211
Range on HMM: 26-269/274.0
SQNKDKNRSTQFLPPDNYRVPLKGE-----HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSV
. .. ||| .. || .| || |. |       .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .| ..| | .|.| . ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

VIGEYF----IELENETRNNGYIERTFEIKNSNKtaiRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAA
 | | .    |. |. ...|.|  |.. .|....   . ||. |  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |. 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
 .... . |.|.||...    |... | |||  ||| | ...  || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 977-1211 9.5e-43 141.0 In-house 41-277 (515) alignment
Range on Protein: 977-1211
Range on HMM: 41-277/515.0
SQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS--SGSV
  |  |||    || |. || |       | ||.|| .|....  ||.| .  |   .  .||... . |||.|.|. . .|  .  | .|||   . ||
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

VIGEYFIELENETRNNGYIERTFEIKNSNKtaIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
  |.. .||       | | |....  ...  .|  | |.. |.|   |  |. ...| .. |. .... . . ....|||  |||  .....   . . 
kfGsikvelvsleactggikrkltvlkgdd..sr.tvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvaha

KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
||  ..|||....  | ..|  |||  ||  | ..|| .| 
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 977-1209 1.1e-22 75.0 In-house 35-268 (281) alignment
Range on Protein: 977-1209
Range on HMM: 35-268/281.0
SQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVV
  |. ||| ..    |  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | ... | .|.|    ..
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

--IGEYFIELENETRNNGYIERTFEIKNSNKTaiRLsVVQYQITNWDstgEVKNPQTIlMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINK
  . .. .. |. | |.  .   ...    .|  || . ..   .|    . . |..   .| .. |  | |  |  |.|||  ||||  . |   ... 
lqfdklsvsyedstvnkslvttrlnlsyeget..rl.ithwlwkewp...dwqvpess.evmlkilrkirar.stppvihcsagvgrsgtlmaveialqs

CKTEG-VIDVFQVLKSQRIQ-KPGSVQTVTQYEGICQIVLAY
 ..   . |. |..   |.  .  ||||. ||  | ...| .
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 977-1210 8.3e-20 65.6 In-house 53-289 (305) alignment
Range on Protein: 977-1210
Range on HMM: 53-289/305.0
SQNKDKNRSTQFLPPDNYRVPLKGEHP-DYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS-GSVVIG
  .. ||| ..    |.  | |.   | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  || .  | |||| . |  .  
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

EYFIELENETRNNgYIERTFEIKNSN-----KTAIRLSVVQYQITNWDSTGEvknPQTILMIMEEMYRTqRkRGNTSIVVHCSDTVGRSAMFCAAATTIN
   | .|| . ..  .||  ||. .          ..|| . | |.|   |    |   |  .| .    |   .  ||||||  .||.    |    ..
ksgivvenvsgsk.pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppckltslellsai.r.gskvpivvhcsagigrtgtivaieyile

KCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
|   .  .  . ...|. | |.  |.|.  ||  | ...| |.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 977-1068 4.5e-15 50.3 In-house 31-126 (297) alignment
Range on Protein: 977-1068
Range on HMM: 31-126/297.0
SQNKDKNRSTQFLPPDNYRVPLKGEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG
.    ||| .. |  |. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|  .. |. ||||. 
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 977-1059 1.7e-07 25.1 In-house 32-118 (332) alignment
Range on Protein: 977-1059
Range on HMM: 32-118/332.0
SQNKDKNRSTQFLPPDNYRVPLKGE--HPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENEL-KQQA
 .| | ||  ..   |  || |  .  . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |...   .|  |..|
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 978-1211 5.1e-35 115.6 In-house 37-278 (287) alignment
Range on Protein: 978-1211
Range on HMM: 37-278/287.0
QNKDKNRSTQFLPPDNYRVPL--KGEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG-SVVIG
 .  ||| .. || |. || |  .||.  ||||| .. .|....||| | .|.  | |.||... .......... .| |  .. ||.|||     . .|
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFI-ELENETRNNGYIERTFEIKNSNKTAIRLsVVQYQITNWdsTGEVKNPQ---TILMIMEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATT
 | .  |. . ..  |  |.. . . .    |. | |... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . 
GysvvlldydikePeygvralrlidletrearv.vkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
... .  | .|| .|.   | .. . ||.| |.  ... . .|  
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 978-1207 1.8e-30 100.9 In-house 2-236 (237) alignment
Range on Protein: 978-1207
Range on HMM: 2-236/237.0
QNKDKNRSTQFLPPDNYRVPLKGE--HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGS-VVIG
.|| |||  .    |  || |||     ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    | ... |..||||.      |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYFIELENETRNNGYIERTFEIKN-SNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK
 . . |  .     |  |.. . .  ..  .|| . |||.| |   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..|
vltvslkkkeefsdytvrslllskrltlkevrl.ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
 . |.|... ..|   ..|  .||  ||  | | .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

0049772 (Phosphotyrosine protein) phosphatases II 978-1216 1.9e-26 89.0 In-house 45-286 (314) alignment
Range on Protein: 978-1216
Range on HMM: 45-286/314.0
QNKDKNRSTQFLPPDnYRVPLKG---EHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM--------------
 |.||||....|| |  || |.|   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCHENELKqqacyqywpssgS-------VVIGeyfielenetrnngyiertfEIKNSNkTAIRLSVVQYQITNWDStGEVKNPQTILMIMEEM
       |.   ..             .         .                     |. ...       ...|  ....  |..  .. .. ..| .
aAlgKtpllildgng............neptaadlellk....................eelydp.elferlgikylripvpD.gsaplledfdeflefi

YRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVTQYEGICQIVLAYLDSFQTY
 .    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |....  ||| | ...| ||. ....
eea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 978-1211 8.6e-22 72.5 In-house 42-272 (288) alignment
Range on Protein: 978-1211
Range on HMM: 42-272/288.0
QNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS-GS-VVIGEY
.|  ..| ..    |  || |. .   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |. ...  .|.||  |  . || .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

fIELENETRnnGYIERTFEI---KNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
      . |    |... ..   ..|...  .  | .  . .||  |  .| .. | ..| .     |  .  ||||.|  |||.. .      ..  . 
.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrl

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
.  . . ..|.. | ..  ..||  ||  . ..|| .| 
ddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 978-1086 1.2e-11 38.9 In-house 46-169 (350) alignment
Range on Protein: 978-1086
Range on HMM: 46-169/350.0
QNKDKNRSTQFLPPDNYRVPLK------------GEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQA
.   ||| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  . ||  . 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CYQYWPSSGsvvIGEYFIELENETRNN
||.||.  .   . .. . |..  .| 
cyrYWqegs...ydditvklaskweni

Y_phosphatase Protein-tyrosine phosphatase 979-1207 4.4e-64 211.5 Pfam-A 1-234 (235) alignment
Range on Protein: 979-1207
Range on HMM: 1-234/235.0
NKDKNRSTQFLPPDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP--SSGSVVIGE
||.|||....|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....| ....| ||||  ...|.  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YFIELE-NET-RNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
...||. .|.  ...|. |..|.|....   . .| |...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
|. .||.|..|. | |.||.||...||. .....|
eeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 979-1207 4.4e-64 211.5 In-house 1-234 (235) alignment
Range on Protein: 979-1207
Range on HMM: 1-234/235.0
NKDKNRSTQFLPPDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP--SSGSVVIGE
||.|||....|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....| ....| ||||  ...|.  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YFIELE-NET-RNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
...||. .|.  ...|. |..|.|....   . .| |...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
|. .||.|..|. | |.||.||...||. .....|
eeevdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 979-1209 9.2e-33 108.7 In-house 1-170 (182) alignment
Range on Protein: 979-1209
Range on HMM: 1-170/182.0
NKDKNRSTQFLPPDNYRvplkgeHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenelkqqaCYQYWPssgsvvigeyfie
|.|||| . .||.|. |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

lenetrnngyiertfeiknsnkTAIRLSVVQYQITNWDSTGEVKnPQTILMIMEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDV
                      .     ..||. ..|.  |    ....| ..||...      .  ..||||  |||.....||   . .    | ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
....|  | ..||.|.|  ||  . ...| .
eeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 979-1207 2.2e-28 94.0 In-house 7-237 (239) alignment
Range on Protein: 979-1207
Range on HMM: 7-237/239.0
NKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIg
|| ||| .. .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    | ... |.|||| | |    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

EYFIELENETRNNGYIERTFEIKNSNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
.  . | .      || ||| . .  .|  |  | ||..| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .
nlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
  .|.|. .|. | ..|  |||  ||  |   ||
ktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 979-1206 2.8e-28 93.7 In-house 8-237 (239) alignment
Range on Protein: 979-1206
Range on HMM: 8-237/239.0
NKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIg
|| ||| .. .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    | ... |.|||| | |    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

EYFIELENETRNNGYIERTFEIKNSNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
.  . | .      || ||| . .  .|  |  | ||..| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .
nlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
  .|.|. .|. | ..|  |||  ||  |   |
ktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 979-1216 4.2e-15 50.2 In-house 43-282 (312) alignment
Range on Protein: 979-1216
Range on HMM: 43-282/312.0
NKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG-------SVV
 || ||  .    |  |  | |.   || | |..     . |.....|. ||. .||..      |.|..||   |   . | .|              |
fkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

IGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTIN
  ||  |.|   . .  |         . |     . .|| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... 
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalr

KCKTEGVIDVFQVLKSQRIQkpgSVQTVTQYEGICQIVLAYLDSFQTY
. . . | |.| .|. .| .   ||... ||    ..|| .| |   |
hprkqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskgly

subfamily_eak_pd Subfamily eak 986-1121 4.3e-09 30.2 In-house 58-195 (332) alignment
Range on Protein: 986-1121
Range on HMM: 58-195/332.0
TQFLPPDNYRVPLKG---EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG--SVVIGEYFIELE
 . .| | | | |     ..  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. ||| .   .|.|  .   .  | . .|  
vkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverk

NETRNNGYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEV
.  ..| .  | .|..  |.|     |  |..  |  |   
efvkrniletrllelskGneth...rvlhykvfGwtettlp

0046846 (Phosphotyrosine protein) phosphatases II 995-1211 1.2e-28 95.5 In-house 4-174 (176) alignment
Range on Protein: 995-1211
Range on HMM: 4-174/176.0
RVPLKGEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIgeyfielenetrnngyiertfe
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. | ||..  |..|||   .. |                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

iknsnktairlsvvQYQITNWDSTGEVKNpQTILMIMEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              ||. ..|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTVTQYEGICQIVLAYLD
||  ||. . . .| .|.
qtpeQyrflyefellllk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 995-1206 2.8e-17 57.8 In-house 34-255 (290) alignment
Range on Protein: 995-1206
Range on HMM: 34-255/290.0
RVPLKGE----HPDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENELKQQ----ACYQYWPSS--GSVVIGEYFI
||.|||       ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .| ...    || .| | |  ... ..   .
rvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

ELENETRNNGYIERTFEIKNSNKTaiRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVI
.  .   ... ..|. ..|  ..    . |  ... .|...   ....|.| ... .     |  .| ..||| | . |||.. |      |   |.| .
kCkskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

DVFQVLKSQRIQKPGSVQTVTQYEGICQIV
 . .|||. | |.   ... ...  .   .
kledvlkalrkqralaitsalelafvdagi

0043147 (Phosphotyrosine protein) phosphatases II 1001-1203 2e-27 91.4 In-house 3-154 (172) alignment
Range on Protein: 1001-1203
Range on HMM: 3-154/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnelkqqacyqywpssgsvvigeyfielenetrnngyiertfeikNSNK
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                              ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TAIRLSVVQYQITNWDSTGEVkNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVTQY
.    ...||. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.  ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

EGIC
  ..
rfly

0044763 (Phosphotyrosine protein) phosphatases II 1001-1205 5.6e-22 73.7 In-house 16-166 (178) alignment
Range on Protein: 1001-1205
Range on HMM: 16-166/178.0
EHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSvvigeyfielenetrnngyiertfeiknsnk
|  |||||..| ..     ....  |.     ...... . ..|.||.|..| || .. |..|||.. .                               
ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

tairlsvVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVTQYE
       .||. ....  |.   .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..  |..
.......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

GICQI
 ....
qLyef

0051429 (Phosphotyrosine protein) phosphatases II 1002-1215 3.2e-35 117.5 In-house 3-230 (272) alignment
Range on Protein: 1002-1215
Range on HMM: 3-230/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENELKQQACYQYWP------------SSGSVVIGEYFIELENETRNN
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.|.... |..|||            |  .. .| ... |  |.  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPqtILMIMEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------V
 || |......  ..   . | ... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
.....  | | ||.||| .||. .....|..|.|...
eeaveelraqrpgavqteeqylflyeallellrslls

0051082 (Phosphotyrosine protein) phosphatases II 1002-1202 3e-22 74.3 In-house 2-145 (151) alignment
Range on Protein: 1002-1202
Range on HMM: 2-145/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENELKqqACYQYWPSSGsvvigeyfielenetrnngyiertfeiknsnkt
..||||. .. |.     ...   |       |.... . ....||.|. | | .   |..|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

airLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVTQYEG
   . |....|..|. .|   .....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. .|.  
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

I
.
q

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1002-1123 5.2e-10 33.7 In-house 12-129 (130) alignment
Range on Protein: 1002-1123
Range on HMM: 12-129/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKqqacyQYWPSSGSVVIGEYFIELENETRNN-GYIERTFEIKNSNK
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|       .||| |  .   |  | .    |..  .|. ..   .|. 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnleiesdl

TAIRLSVVQYQITNWDSTGEVKN
     ..  .||.|| | |   |
neshqaltmfqisnwpsdgttpn

0036282 (Phosphotyrosine protein) phosphatases II 1004-1204 1.1e-33 111.7 In-house 3-164 (174) alignment
Range on Protein: 1004-1204
Range on HMM: 3-164/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSsgsvvigeyfielenetrnngyiertfeiknsNKTAI
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.||.   |..|||.                                ...  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

RLSVVQYQITNWDSTGEVKNPQtILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVTQYEGIC
. ...||. ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||  ||. . 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y

0049260 (Phosphotyrosine protein) phosphatases II 1010-1203 5.3e-26 86.5 In-house 1-143 (152) alignment
Range on Protein: 1010-1203
Range on HMM: 1-143/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWpssgsvvigeyfielenetrnngyiertfeiknsnktairlsvvQ
||.||. ...||... |. ||. .||.|. . ..|.||||. . ||.   |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YQITNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVTQYEGIC
|. ..|.  |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..  |.. . 
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1011-1098 1.8e-10 34.7 In-house 229-314 (440) alignment
Range on Protein: 1011-1098
Range on HMM: 229-314/440.0
INGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcheNELKQQACYQYWPSS-GSVVIGEYFIELENETRNNGYIERTFEIKNS
..||  |.||| .. |.  |  .||... | ....|.||   |.|....|  |||    || .| . .        |    ||.|.|  
fegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1015-1204 6.1e-14 46.6 In-house 2-198 (199) alignment
Range on Protein: 1015-1204
Range on HMM: 2-198/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFeIKNSNKTAI--RLSVVQY
| .. .| .. |. .|  .||.|. .     |||.  ..  |.     |||..  |.   |   .  .  | .  |   .. |  .| ||      . .|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishy

QITNWD--STGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQ
|.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . .. .|. | |
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1016-1204 8e-14 46.3 In-house 2-197 (198) alignment
Range on Protein: 1016-1204
Range on HMM: 2-197/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFeIKNSNKTAI--RLSVVQYQ
 .. .| .. |. .|  .||.|. .     |||.  ..  |.     |||..  |.   |   .  .  | .  |   .. |  .| ||      . .||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyq

ITNWD--STGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQ
.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . .. .|. | |
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1017-1210 8.6e-10 31.7 In-house 114-309 (346) alignment
Range on Protein: 1017-1210
Range on HMM: 114-309/346.0
KKAFIIAESPMFN---TARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQi
.. .|.|. | ..      .|| || . ..  . ..  .. ||. .   .    |     |  ||.           | | |.    ..   .  |... 
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhh.

TNWDSTGEvkNPQTILMI-MEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
. |    .   |.|. .| |   . ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|.. .|| .|  ||. |.
apwkhlqq..ppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

subfamily_hpo-7_pd Subfamily hpo-7 1022-1195 5.7e-13 43.4 In-house 42-212 (263) alignment
Range on Protein: 1022-1195
Range on HMM: 42-212/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRnnGYIERTFEIKN--SNKTAIRlSVVQYQITNWDS
.    . .|  .|...|   . . .||||  ||  .. | .|.|    .  .. .  .   .       . .| |. .  ..|  ..  | .|. . |  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkth.tvkhysykgWie

TGEVKNPQTILMIMEemyrTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQT
. ...... || |..        |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......|
kndpelareilnilk....va..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraiht

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1023-1199 5.3e-15 49.7 In-house 96-277 (302) alignment
Range on Protein: 1023-1199
Range on HMM: 96-277/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS--SGSVVIGEYFI-------ELENETRNNGYIERTFEIKNSNKT-AIRLSVVQYQI
   |  .|   .| .|.. ||. .| ||.  | ... | .|.     | .  |.| .       .||. |  ...   | ||||..|. . . .|   . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGEVKNPQTILMIMEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQY
. |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||. .| 
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

0048179 (Phosphotyrosine protein) phosphatases II 1037-1203 6.3e-13 44.2 In-house 24-138 (144) alignment
Range on Protein: 1037-1203
Range on HMM: 24-138/144.0
MIDDRNVTAIVMLCHENELKQQACYqywpssgsvvigeyfielenetrnngyiertfeiknsnktairlsVVQYQITNWDSTGEVKNPQTILMIMEEMYR
.. . ..|... |..| |     ..                                             ..||. ..|.  |    .. .| ..| . .
llkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefiee

TQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVTQYEGIC
 ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..  |.. ..
ale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl

0048076 (Phosphotyrosine protein) phosphatases II 1088-1207 3.4e-13 45.0 In-house 29-140 (145) alignment
Range on Protein: 1088-1207
Range on HMM: 29-140/145.0
YIERTFEIkNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRI
 | . . .  |...     ..||. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | 
gittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrs

QKPGSVQTVTQYEGICQIVL
| ||.|... |.. ... .|
qrpgavpnpgqlrflyefel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1104-1167 1.8e-06 21.9 In-house 214-286 (350) alignment
Range on Protein: 1104-1167
Range on HMM: 214-286/350.0
RLSVVQYQITNWDSTGEVKNPQTILMIME--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATTI
 . | | |. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....    .
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsll

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1106-1210 6.8e-13 42.7 In-house 90-194 (440) alignment
Range on Protein: 1106-1210
Range on HMM: 90-194/440.0
SVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
.. ||.   |   |  |    .| .....  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||  ||  . . 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

VLAYL
||  |
vlegl

PTPc_DSPc_SM00012 1107-1207 3.3e-21 70.8 In-house 2-104 (105) alignment
Range on Protein: 1107-1207
Range on HMM: 2-104/105.0
VVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQ
| .|..|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| .||  ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IVL
..|
all

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1129-1210 4.6e-09 30.5 In-house 215-295 (297) alignment
Range on Protein: 1129-1210
Range on HMM: 215-295/297.0
MIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
..  | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||. |.| . ..||. |
flqleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_CG42327_pd Subfamily CG42327 1139-1209 1.2e-07 25.7 In-house 243-314 (319) alignment
Range on Protein: 1139-1209
Range on HMM: 243-314/319.0
RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|. ||| | ...  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey