Gene PTPRD-12 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP065_AA protein Get Run
AqueP065_AA_789-922 phosphatase_domain Get Run
AqueP065_AA_936-1211 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 293-375 2e-13 43.5 Pfam-A 3-83 (85) alignment 
Range on Protein: 293-375
Range on HMM: 3-83/85.0
VDDIMFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
. .. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 398-469 3.7e-13 42.6 Pfam-A 11-84 (85) alignment 
Range on Protein: 398-469
Range on HMM: 11-84/85.0
KNPDAINIIWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYGIFGLIPNTSYTIGVRAYTSIGPGDW
 ... ... |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | | .
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
Herpes_gE Alphaherpesvirus glycoprotein E 571-656 9.4e-07 17.5 Pfam-A 329-407 (439) alignment 
Range on Protein: 571-656
Range on HMM: 329-407/439.0
QPIPPADIPTSTSDAANGSSAIFIA-IGAVVCILVLIVIIAIIVVVIVLKKRRSSKNIdivskntSANKPEATVYYSTCKNNNnDAG
.. |... |....   ....| . . ..||....||.......|.|.| |.|| ..         .  .|...|| |  .|.   . 
sdppatpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkaye.......krlspfspvYtsLPtnel.ved
DUF4577 Domain of unknown function (DUF4577) 576-635 9.1e-06 12.1 Pfam-A 46-100 (128) alignment 
Range on Protein: 576-635
Range on HMM: 46-100/128.0
ADIPTSTSDAANGSSAIFIaigaVVCILVLIVIIAIIVVVIVLKKRRSSKnIDIVSKNTS
 .|| . .|. ||| ..|.    |  |||||| .|... || |  .   | .| ||.  .
ekipdagtdpgngsrglff....vglilvlivslalvsfviflivqtgnk.mddvsrrlt
Ig_3 Immunoglobulin domain 678-752 1.5e-07 23.5 Pfam-A 1-75 (75) alignment 
Range on Protein: 678-752
Range on HMM: 1-75/75.0
KPVIEEFPSNMTTEEGCqVLLKVKVKETS-KPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHEGTYRFVANN
||||   ||...|..|  | |   .. .. .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 678-765 1.4e-06 20.3 Pfam-A 1-80 (80) alignment 
Range on Protein: 678-765
Range on HMM: 1-80/80.0
KPVIEEFPSNmtTEEGCQVLLKVKVKETSKPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHEGTYRFVANND-AGTVSQQVVLTV
|||... |..   .||..| |  ...   .|.. ||..||...   .        |.. .|.... |||. .| |.  ...|. | .||
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
I-set Immunoglobulin I-set domain 679-765 5.8e-15 46.9 Pfam-A 1-90 (90) alignment 
Range on Protein: 679-765
Range on HMM: 1-90/90.0
PVIEEFPSNMTTEEGCQVLLKVKVKETSKPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHEGTYRFVANNDAGTVSQQVVLTV
|.... .......|| .| |...|... .||..|...|.... .  .... ..   .| . .||.. ||.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
0051299 (Phosphotyrosine protein) phosphatases II 785-911 5.3e-33 110.1 In-house 3-136 (288) alignment 
Range on Protein: 785-911
Range on HMM: 3-136/288.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGP
. |.|... |.| . .|.|.  .. .| .| |    .. ...|   |.  ||. .|. ||..|..|....|  . .. |||| |.||| .. ..||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

MSKTLVDFWCLVWQERPPVIVMVTNH---------Q
...|. ||| .||... .||||.|.          |
lpntvedFWrmvweqnvrvIvmltklvelgrekcaq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 785-909 4.2e-28 93.3 In-house 3-124 (319) alignment 
Range on Protein: 785-909
Range on HMM: 3-124/319.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEhSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGP
. |.|... . . . ...|.  .. .| .|. .... . .      ||  ||. ||. ||  |..| .. | ..   .|||| ..|||    ..||||.|
teievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaP

MSKTLVDFWCLVWQERPPVIVMVTN
...|. ||| .||.|.  ..||.|.
lentiedfWrmvWeeessivvmltk
subfamily_PTPRB_pd Subfamily PTPRB 785-909 3.5e-27 90.2 In-house 5-127 (293) alignment 
Range on Protein: 785-909
Range on HMM: 5-127/293.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGP
. | ...| ..|.. .|. . .|. .. .| . ..... ..  .. |.  ||. ||. || .|. | .......   .|||| |..||.|  ..||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynsprefiatqGP

MSKTLVDFWCLVWQERPPVIVMVTN
. .|. ||| .||...  .|||.|.
lpetvddfWrmvwekkssiivmltq
subfamily_PTPRA_pd Subfamily PTPRA 785-910 5.1e-25 83.1 In-house 12-135 (330) alignment 
Range on Protein: 785-910
Range on HMM: 12-135/330.0
NLIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGP
  .|| .. . .    |   . |. .|  | .|. . .  .     ||  ||. ||. || .|.|| ...|...   .|||| ..|||    ..||.|||
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees..dyinasfidGykekdkfiaaqGP

MSKTLVDFWCLVWQERPPVIVMVTNH
 ..|. ||| ..|. .   |||.|. 
keetvedfwrmiweqksativmltel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 785-911 1.6e-19 65.2 In-house 8-127 (297) alignment 
Range on Protein: 785-911
Range on HMM: 8-127/297.0
NLIPVRQFGKFVANGHAKgkEEFKTQFTMLdsGES-EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYSSdyQYIATQG
. ||. .|  .| ...    . |. .|  |   |.  ...||     |   .|..||. || .|..|. .   .|   .|.|| .| |.    ..|.|| 
rpiplsdfatlvqknrht..dvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqm

PMSKTLVDFWCLVWQERPPVIVMVTNHQ
||  |. ||| .|..|.. .|||... .
PmkatvadfWamvldeqvstivmlnddn
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 786-910 3.6e-62 204.8 In-house 1-125 (290) alignment 
Range on Protein: 786-910
Range on HMM: 1-125/290.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPHEYINACYVDGYSSDYQYIATQGPM
|||| .||.|||||||||.| |..||.|||||||||..||||.||||||||||||||||||||.||||||||||..|||||||..||. ..||||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SKTLVDFWCLVWQERPPVIVMVTNH
|.|||||| |.|||. ..|||.|| 
sntlvdFWkliwqekvtiivmltni
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 786-910 1.5e-51 170.0 In-house 1-120 (287) alignment 
Range on Protein: 786-910
Range on HMM: 1-120/287.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDS-GESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRpisghkDCPHEYINACYVDGYSSDYQYIATQGP
||||..||.|||.|||||.|.||.|||.|.. ...|.. |....|.|| .||...|.|.|..|..|.      .. ..||||...|||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

MSKTLVDFWCLVWQERPPVIVMVTNH
|..|...||.|........|||....
mfntarnfWkliddrnvtaivmlcqe
subfamily_PTPRD_pd Subfamily PTPRD 786-910 2.1e-36 120.7 In-house 4-125 (564) alignment 
Range on Protein: 786-910
Range on HMM: 4-125/564.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGeSEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPM
 ||| .. ..||. .|... .|....  ...| .... ..   . ||  ||.|||| || .|..|... |....  .|||| ..||| .. .|||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

SKTLVDFWCLVWQERPPVIVMVTNH
..|. ||| .||...  .|||.|. 
aetiedFWRmvweqnsstiVmltkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 786-909 1.5e-29 98.1 In-house 3-122 (305) alignment 
Range on Protein: 786-909
Range on HMM: 3-122/305.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGesEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKdcPHEYINACYVDGYSSDYQYIATQGPM
 | . .. ... . ... ......|. .| .   |.|  || .. ||  ||...|...||.||||.. . ..   ..||||.|||||..  .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

SKTLVDFWCLVWQERPPVIVMVTN
 .|..||| |...|.. .|||.|.
kntvadfWrliveekvstivmltk
0045450 (Phosphotyrosine protein) phosphatases II 786-913 2.2e-28 95.3 In-house 8-144 (307) alignment 
Range on Protein: 786-913
Range on HMM: 8-144/307.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGES--EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkDCPHEYINACYV--------DGYSSD
.|..... ..|.  ...... .. .| .| | .    .. ...|.  || .||. .|. ||..|..| ...|. . .. |||| ||        ||| ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYI
 ..||||||...|. ||| ..|...  ||||.|.  . 
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 786-909 4.6e-23 76.6 In-house 5-125 (315) alignment 
Range on Protein: 786-909
Range on HMM: 5-125/315.0
LIPVRQFGKFVANGHAKGKEEFKTQFTMLDSGEsEHSATVGLSSSNKLLNRFANIVVYDDNRIILrPISgHKDCPHEYINACYVDGYSSDYQYIATQGPM
 ||. |.  .||. .|  |. || ..  .  |.  |   |   . ||  ||. ||. ||  |. | |.   .|   .|.|| ..|||.   .|||.||| 
pipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidGynkkrryiaaqgpn

SKTLVDFWCLVWQERPPVIVMVTN
  .. ||| ||..|    |||.||
vasvkdfwrlvfeedigkivmltn
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 786-910 3.7e-21 70.0 In-house 3-122 (392) alignment 
Range on Protein: 786-910
Range on HMM: 3-122/392.0
LIPVRQFGKFVANGHAkgKEEFKTQFTMLDSGEsEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPM
 ||| ||  || . .      |  .|  | . .  .  ||.    |.  ||. ||. || .|..|  |    |  ..|.|| |.... ..  |||.||| 
pipvaqfpafveknrh..salffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpn

SKTLVDFWCLVWQERPPVIVMVTNH
. .| ||| .|.||..  |.|||. 
aaslddfwrmvfqenvttiamvtkl
subfamily_PTPRG_pd Subfamily PTPRG 787-909 6.4e-32 105.5 In-house 1-124 (563) alignment 
Range on Protein: 787-909
Range on HMM: 1-124/563.0
IPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEH--SATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPhEYINACYVDGYSSDYQYIATQGP
.||..| | ||. ||.|.  |. .|  | |   ..   |.     .||  ||  ||| ||  |. |.|..|.|.   .|||| |.|||    ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MSKTLVDFWCLVWQERPPVIVMVTN
. .|. ||| ..|...  .|||.||
lkdtfddFWrmiWeqnvaiivmitn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 787-910 1.5e-30 101.4 In-house 2-123 (318) alignment 
Range on Protein: 787-910
Range on HMM: 2-123/318.0
IPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMS
|.|... . |.. ...|. ...... .|.  |.. ...  |.. ||  ||.|||. ||. |. |....|...   .|||| |.||| .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegs..DyinanyidGyrrkkayiaaqaPlp

KTLVDFWCLVWQERPPVIVMVTNH
.|. ||| .||.    ||||.|. 
etieDfWrmvWeqnsavivmltqe
0043336 (Phosphotyrosine protein) phosphatases II 787-911 3.4e-26 87.8 In-house 2-123 (278) alignment 
Range on Protein: 787-911
Range on HMM: 2-123/278.0
IPVRQFGKFVANGHAKGKEEFKTQFTMLDSGESeHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMS
|.| .. |.... ....|  .. .|  |.|     . ...|.  || .||. .|. || .|..| ...|. |  . |||| |||||.   ..||||||..
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlp

KTLVDFWCLVWQERPPVIVMVTNHQ
.|. ||| .||... ..|||.|.  
etvedFwrmvwelgvttivmLtelv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 787-911 2.8e-22 74.0 In-house 3-122 (315) alignment 
Range on Protein: 787-911
Range on HMM: 3-122/315.0
IPVRQFGKFVANGhaKGKEEFKTQFTMLDSGEsEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYSSDYQYIATQGPMS
||| ||  || .   .    |  .|  |   .  .  .|.  . |   ||. ||. .| .|..|  |   ..  ..|||| |. .. .|  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlk

KTLVDFWCLVWQERPPVIVMVTNHQ
 .. ||| .|.||..  |||||. |
asvddfwrmvlqekvttivmvtkkq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 787-910 8e-21 68.7 In-house 2-120 (515) alignment 
Range on Protein: 787-910
Range on HMM: 2-120/515.0
IPVRQFGKFVAN-GHAkgkEEFKTQFTMLdSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISghkDCP-HEYINACYVDGYSSDYQYIATQGP
.|. ||  ||.  .|.     |  .|  |  |   .  ||     |   ||. ||. || .|..|  |    | | ..|.|| |. .. .|  |||.|||
lplaqfPafvnknrht...tlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevin...dnPhsdyfnasyipsfdndkayiasqgP

MSKTLVDFWCLVWQERPPVIVMVTNH
   .. ||| ||.||..  |.|||. 
nkasvddfWrlvlqenvttiamvtkl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 788-883 1.3e-13 45.0 In-house 6-95 (95) alignment 
Range on Protein: 788-883
Range on HMM: 6-95/95.0
PVRQFGKFVANGHAKGKEEFKTQFTMLDSgESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpiSGHKDCphEYINACYVDGYSSDYQYIATQG
 |  |   | . |..  .||  .|  .    |  . ||| | .|   ||| ||. ||  |..|   . ..|   .|||||.||||.    |||.||
hvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrds..dyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 788-874 2.6e-08 27.6 In-house 7-88 (440) alignment 
Range on Protein: 788-874
Range on HMM: 7-88/440.0
PVRQFGKFVANGhaKGKEEFKTQFTMLDSGESEHSATVGLSsSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSS
 | .|  .| |   .    |. ....| || |. |   .|  .||. ||. ||..|| .|..|  . |  |   .|||| |..|  |
ivadfadyvqnn..rrsrafedewsllpsglsqpsdiaslp.nnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingies
0050432 (Phosphotyrosine protein) phosphatases II 789-912 1.2e-29 99.0 In-house 28-144 (308) alignment 
Range on Protein: 789-912
Range on HMM: 28-144/308.0
VRQFGKFVANghAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisghkDCPHEYINACYVDGY--SSDYQYIATQGPMS
| .. |.. .  |...  ....|  | |    .. .|.|   || .||. .|. || .|..|       | .. |||| |||||   .. ..||||||..
vldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlp

KTLVDFWCLVWQERPPVIVMVTNHQY
.|. ||| .||... .||||.|. ..
ntvedFwrmvweqnvrvIvmLtklve
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 790-909 3.4e-26 87.2 In-house 12-132 (298) alignment 
Range on Protein: 790-909
Range on HMM: 12-132/298.0
RQFGKFVANGHAKGKEEFKTQFTMLDSGES---EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMS
... |..|  ..|.   ....|  |.|..|   |.. .|. ...||  ||.|.|. .|  |..|. ... ...  .|||| ....|.    .||||.|. 
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPlt

KTLVDFWCLVWQERPPVIVMVTN
.|..||| .|..|   .|||.||
etvedFWrmvteedigtiVmltn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 791-910 3.1e-13 44.1 In-house 8-122 (305) alignment 
Range on Protein: 791-910
Range on HMM: 8-122/305.0
QFGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisgHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLV
|  ||| .   || . ....|. .   .  .       . ..  ||. ..   |.||. |     .   ||||| | ||   .   ..| || |. ||  
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektca

DFWCLVWQERPPVIVMVTNH
||| . .|..   | |. | 
dfwymclqdkveaifmlcnl
0040438 (Phosphotyrosine protein) phosphatases II 792-913 3.7e-28 94.2 In-house 5-123 (317) alignment 
Range on Protein: 792-913
Range on HMM: 5-123/317.0
FGKFVANGHAKGKEEFKTQFTMLDSGESEhSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVD
. ...   .....  .. .| .|.|   . . .|..   || .||. .|. ||..|..| |..|  | .. |||| ||||..   ..||||||...|. |
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWCLVWQERPPVIVMVTNHQYI
|| .||...  ||||.|.  . 
FwrmvweqgvtvivmLteleel
subfamily_Ptp69D_pd Subfamily Ptp69D 792-910 5.7e-26 86.3 In-house 9-125 (307) alignment 
Range on Protein: 792-910
Range on HMM: 9-125/307.0
FGKFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVD
  . . . . . .. ..  . .| . |...|..|.    |.| ||. .|. .|..|..|..| |..|   .|||| .. ||    ..|| |.|.  |. |
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigD

FWCLVWQERPPVIVMVTNH
|| ....    .|||..| 
fWRmiaeqevtlivmlsnl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 792-908 1.7e-12 41.5 In-house 14-126 (310) alignment 
Range on Protein: 792-908
Range on HMM: 14-126/310.0
FGKFVANGHAKGKEEFKTQFTMLDSgESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRpIsgHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVD
. .|.      | | .  |.  ||. . . | |      .   ||....|. |. |. |. |   |   ..|| | ||        .| .|||. .|..|
lenfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk.i..dksryedyihanyvktnylrstficsqgplqhtiid

FWCLVWQERPPVIVMVT
|| ...|||   |... 
fwrmifqeraesilllc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 793-907 3.8e-17 57.4 In-house 11-122 (325) alignment 
Range on Protein: 793-907
Range on HMM: 11-122/325.0
GKFVANGHAKGKEEFKTQFTMLDSGESeHSATVGLSSSNKLLNRFANIVVYDDNRIILRPIsgHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDF
 ..| . .|. .. |  .| .| | ..  . .|     ||  ||| |.| .| .|..|     ..|   .|||| |.  .     ..|.| |...|. |.
vehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindl

WCLV--WQerPPVIVMV
| ||  |.   .|.|..
WrlvldWr..csvvvvl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 794-909 4.5e-25 83.3 In-house 10-123 (288) alignment 
Range on Protein: 794-909
Range on HMM: 10-123/288.0
KFVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFW
. ||. .|.....|. ..  | . |...| |.|  . |.  ||. ||. || .|. |.     ..   .|||| |.||. .. .|||||||. .|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndfW

CLVWQERPPVIVMVTN
 ||....   |||.|.
elvyenktstivmlte
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 794-909 2.3e-17 57.6 In-house 9-124 (439) alignment 
Range on Protein: 794-909
Range on HMM: 9-124/439.0
KFVANGHAKGKEEFKTQFTMLDSGESEH--SATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVD
. | . . . .| ||  | ...| . ..   |..   . ..  ||. ... .|  |..|. | |       |||| |..||  |  |||||||  .|  |
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphs..hyinanyikGyyddklyiatqgpkkettdd

FWCLVWQERPPVIVMVTN
|| ||....   |||.||
fwrlviekktvtivmltn
0039614 (Phosphotyrosine protein) phosphatases II 795-912 4.1e-26 87.6 In-house 22-137 (297) alignment 
Range on Protein: 795-912
Range on HMM: 22-137/297.0
FVANGHAKGKEEFKTQFTMLDSGESEhsATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkDCPHEYINACYVDGYSS-DYQYIATQGPMSKTLVDFW
..   .|..|  ....| .| |   .   ...|.  || .||. .|. ||..|..| |. |. | .. |||| |||||.  . ..||||||...|. |||
llllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

CLVWQERPPVIVMVTNHQY
 .||... .||||.|.  .
rmvweqgvtvivmLtklve
subfamily_PTPN9_pd Subfamily PTPN9 795-909 5.1e-22 73.3 In-house 6-118 (297) alignment 
Range on Protein: 795-909
Range on HMM: 6-118/297.0
FVANGHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWC
.||  ..|||.  . ... . . . |  ...  . .|   ||..... ||. |. |  .....    .|||| .||||     .||||||. ||  ||| 
lvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedea..sdyinanfvdGykqkkafiatqGplkktvsdfWr

LVWQERPPVIVMVTN
.||...  ||||.| 
mvWeqevlvivmttr
subfamily_PTPN6_pd Subfamily PTPN6 798-910 2.2e-24 81.0 In-house 19-132 (306) alignment 
Range on Protein: 798-910
Range on HMM: 19-132/306.0
NGHAKGKEEFKTQFTMLDSGESE--HSATVGLSSSNKLLNRFANIVVYDDNRIILRpisgHKDCP-HEYINACYVDG--YSSDYQYIATQGPMSKTLVDF
... ..|. |. .|  |.  |..  .| . |   .||  ||. ||. .|..|.||.    ... | ..|||| |...   .|| .|||||| ...|. ||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdF

WCLVWQERPPVIVMVTNH
| .||||   ||||.|..
Wrmvwqensrvivmttke
subfamily_ptpA1_pd Subfamily ptpA1 799-909 3.1e-16 54.1 In-house 15-122 (418) alignment 
Range on Protein: 799-909
Range on HMM: 15-122/418.0
GHAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSsDYQYIATQGPMSKTLVDFWCLVWQ
 | |   . | .| .|.       .. |    |   ||..||.  .  |. |. |  ..    .|||| |.||     |.|.||||. .|. ||| .||.
nhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidgay.pkqfictqgplpntiadfwrmvwe

ERPPVIVMVTN
.|  .|||.. 
nrcriivmlsr
subfamily_PTPRN_pd Subfamily PTPRN 799-911 4.6e-15 50.1 In-house 23-135 (297) alignment 
Range on Protein: 799-911
Range on HMM: 23-135/297.0
GHAKGKEEFKTQFTMLDSGESEHSAT-VGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYV-DGYSSDYQYIATQGPMSKTLVDFWCLV
 | | |. .. ..  | . |.| |.. |. .  |   || .... ||..|. |.  . ...  ..||||  . |       |||||||...|. ||| .|
dhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmv

WQERPPVIVMVTNHQ
|..   |||..|. .
weqGvvvivnltrle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 799-909 2.1e-10 35.1 In-house 10-115 (307) alignment 
Range on Protein: 799-909
Range on HMM: 10-115/307.0
GHAKGKEEFKTQFTMLDSGESEhSATVGLSSSNKLLNRFANIVVYDDNRIILRpISGhkdCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQ
   || .... .|..|   . | . ||   |.|   ||. .. . | .||... ..|      .|| | |.       ..|..|||. .|  .||... |
tldkgvqalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiq

ERPPVIVMVTN
|.   ..|. .
ekvesvimlck
0047943 (Phosphotyrosine protein) phosphatases II 800-913 1.7e-28 95.3 In-house 7-114 (273) alignment 
Range on Protein: 800-913
Range on HMM: 7-114/273.0
HAKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisghKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQE
...|.  .. .| .| |   ... .|.|   || .||. .|. ||..|..|      .| .. |||| ||||| .  ..||||||...|. ||| .||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RPPVIVMVTNHQYI
. .||||.|. .. 
nvrviVmLtelvel
subfamily_PTPN23_pd Subfamily PTPN23 800-911 5.6e-21 69.6 In-house 10-118 (288) alignment 
Range on Protein: 800-911
Range on HMM: 10-118/288.0
HAKGKEEFKTQFTMLDSGESEHSA--TVGLSSSNKLLNRFANIVVYDDNRIILRpisGHKDcphEYINACYVDGYSSD-YQYIATQGPMSKTLVDFWCLV
  .|| .....|  |.. . ...   .. ..  .   ||. .|. || ||. ||   |.||   .||||..| . |.   ..||||.|. .|| ||| .|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD...DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WQERPPVIVMVTNHQ
.... .||||.....
yeqkssviVmllske
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 801-911 6.5e-36 118.6 In-house 11-120 (301) alignment 
Range on Protein: 801-911
Range on HMM: 11-120/301.0
AKGKEEFKTQFTMLDSGESeHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQER
|| ...|. |.. |..||. .|.|||||..|| |||| ||.|||||||||.| .  . | .||||| |.||||.  ..||.|||| |||||||.|.|||.
akhsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

PPVIVMVTNHQ
|  |||||| .
pvsivmvtnlk
0036941 (Phosphotyrosine protein) phosphatases II 801-912 1.1e-29 99.1 In-house 9-114 (297) alignment 
Range on Protein: 801-912
Range on HMM: 9-114/297.0
AKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILrpisghKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQER
....  ....|  |..     | .|.|.  |. .||. .|. ||..|..|      .| .. ||||.|||||. ....||||||...|. ||| .||...
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

PPVIVMVTNHQY
 .||||.|.   
vtvIvmltelve
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 801-909 2.1e-25 84.4 In-house 11-117 (281) alignment 
Range on Protein: 801-909
Range on HMM: 11-117/281.0
AKGKEEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQER
.. .. |..... | . . ...||   .  |.| ||. ||| ||  |. . | . .|..  .|||| .|.||... .|||||||. ..||.|| .||...
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

PPVIVMVTN
  .|||||.
vsaivmvtr
subfamily_CG7180_pd Subfamily CG7180 802-910 5.5e-21 69.5 In-house 14-119 (296) alignment 
Range on Protein: 802-910
Range on HMM: 14-119/296.0
KGKEEFKTQFTMLDSGESEHSAtVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERP
| . |.| .. .    |... |  || . |.  ||  ..| || ||..|. . |...    |||| |||..  . .|| |..|. .|. .|| ||..|  
kfrveyklelkltprleigdCa.gglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeei

PVIVMVTNH
  .|..|..
savvvLtkt
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 802-908 7.2e-08 26.4 In-house 25-128 (305) alignment 
Range on Protein: 802-908
Range on HMM: 25-128/305.0
KGKEEFKT--QFTMLDSGESEHSATVGlSSSNKLLNRFANIVVYDDNRIILrpisgHKDCPHEYINACYVDG-YSSDYQYIATQGPMSKTLVDFWCLVWQ
| .|||.   ..|  |  .    |    .  ..  ||.... . | . . |     .|  | .|| | ||      . ..|..|||. .|. .|| .| |
klreefrglakytrpdmtqvafnanqs.adiaitknryqdvpcqdqsavkl.....dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviq

ERPPVIVMVT
..   |||. 
nkveqivmlc
subfamily_PTPN12_pd Subfamily PTPN12 803-909 8.3e-21 69.1 In-house 6-116 (290) alignment 
Range on Protein: 803-909
Range on HMM: 6-116/290.0
GKEEFKTQFTMLDS------GESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDcpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLV
|.|||...|. | .       |...|...| ...|.  ||. .|. || .|. |. |.....   .|||| .. | ... .|||.|||..||| ||| ..
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeeg..sdYinanfikgvegkleyiaaqgPLpktlddfWrmi

WQERPPVIVMVTN
|. .  ..||. .
weknveivvmaCr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 804-908 1.9e-19 64.7 In-house 8-107 (283) alignment 
Range on Protein: 804-908
Range on HMM: 8-107/283.0
KEEFKTQFTMLdsGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkdcphEYINACYVD---GYSSDYQYIATQGPMSKTLVDFWCLVWQER
 . |. ..  |  .  . .|..  .. ||  ||. .||..| .|. |.. |       .||||...     |  | .||..|.|. .| |||| .|..|.
nklfrevlkrl..svpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

PPVIVMVT
   |||.|
itaivmlt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 805-909 2.4e-18 61.1 In-house 6-105 (267) alignment 
Range on Protein: 805-909
Range on HMM: 6-105/267.0
EEFKTQFTMLDSGeSEHSAT--VGLSSSNKLLNRFANIVVYDDNRIILRPISGHkdcpheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPP
 |.. .| ...   |. |.|    ... |.  ||. . . |||.|.|||           |||| ||.||    ..|.||.|...|  ||. .. ... |
ceiekefelikki.sdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvp

VIVMVTN
|||..|.
vivlltk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 805-909 9.3e-13 42.5 In-house 11-114 (281) alignment 
Range on Protein: 805-909
Range on HMM: 11-114/281.0
EEFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCpHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVI
..|| .|. |        .||     |.  ||..|| . |  |. |.     |.   .|| | |.        || ||||  .|  ||| ..|||    |
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkns.tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTN
||. .
vmlcq
subfamily_PTPN1_pd Subfamily PTPN1 806-908 1.4e-15 51.8 In-house 7-103 (290) alignment 
Range on Protein: 806-908
Range on HMM: 7-103/290.0
EFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkdcphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIV
 .|. .. ..   |......    .|. |||. ..  ||  ||.|.  .       .||||  |.    . .|| ||||...|   || .||...   .|
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MVT
|. 
mln
subfamily_egg_pd Subfamily egg 806-909 7.4e-11 36.3 In-house 15-116 (307) alignment 
Range on Protein: 806-909
Range on HMM: 15-116/307.0
EFKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIV
|.. .. .|.    | | |  .|. |.   |   .   |  |. |.   |      ..| | .|.|     ..| .| |.  |  ||| .|.||. . ||
elerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv

MVTN
|.| 
mlts
0046845 (Phosphotyrosine protein) phosphatases II 807-912 1.5e-28 95.4 In-house 2-122 (284) alignment 
Range on Protein: 807-912
Range on HMM: 2-122/284.0
FKTQFTMLDSGESEH--SATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkDCPHEYINACYVDGY-----SSDYQYIATQGPMSKTLVDFWCLVWQE
.. .| .| |    .  | .|.|   |. .||. .|..||..|..|....|. .  ..|||| |||||      .  ..||||||...|. ||| .||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RPPVIVMVTNHQ---------Y
. .||||.|.           |
nvrvIVmltelvengrekcaqY
DSPc_SM00195 807-911 6.4e-28 93.2 In-house 2-104 (263) alignment 
Range on Protein: 807-911
Range on HMM: 2-104/263.0
FKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkdCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVM
.|..|. |.. .|... | .  ..||  ||. ||..||..|..| .. ..   ...|||| |..|.... .|||||||...|. ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNHQ
.|. .
lteee
PTPc_SM00194 807-911 6.4e-28 93.2 In-house 2-104 (263) alignment 
Range on Protein: 807-911
Range on HMM: 2-104/263.0
FKTQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGHkdCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVM
.|..|. |.. .|... | .  ..||  ||. ||..||..|..| .. ..   ...|||| |..|.... .|||||||...|. ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNHQ
.|. .
lteee
subfamily_PTPN3_pd Subfamily PTPN3 809-909 1.2e-16 55.4 In-house 19-117 (280) alignment 
Range on Protein: 809-909
Range on HMM: 19-117/280.0
TQFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRpisghkDCPHEYINACYVD----GYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVI
.|| .|   . . . ..   . |   ||. .|. ||. |..|.      . . .|||| ||.    . .   .|||||||..||  ||| .||...  .|
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMVTN
||.|.
vmltt
subfamily_PTPN13_pd Subfamily PTPN13 810-910 3.3e-17 57.7 In-house 16-111 (273) alignment 
Range on Protein: 810-910
Range on HMM: 16-111/273.0
QFTMLDSGESEHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkdcpheYINACYVDGY--SSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMV
.|. |    .  ...|| . .||  ||. |.. ||. |..|   .|       |||| ..        |.|||.|||. .|  ||| .||. .  ||.||
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TNH
|..
tle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 820-909 3.4e-18 60.6 In-house 9-97 (270) alignment 
Range on Protein: 820-909
Range on HMM: 9-97/270.0
EHSATVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSS-DYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
... ..     .| |||.|.|.     |..| ...   |   .|||| || |... . .|||..||.  || .|| ..|.|. . |||.|.
tsesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttg
0049772 (Phosphotyrosine protein) phosphatases II 820-906 1.8e-14 49.6 In-house 35-126 (314) alignment 
Range on Protein: 820-906
Range on HMM: 35-126/314.0
EHSATVGLSSSNKLLNRFANIVVYDdNRIILrPISGHKDcpHEYINACYVDGYssdYQYIATQGPMSKTLVDF----------WCLV--WQERPPVIVM
|.. .|.    |.  ||. .|. .| || || |  ....  . |||| ||||.    ..||||||.. |.|||          | .|  .. .. .|||
eltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm
0045098 (Phosphotyrosine protein) phosphatases II 822-913 4.3e-23 77.5 In-house 24-101 (278) alignment 
Range on Protein: 822-913
Range on HMM: 24-101/278.0
SATVGLSSSNKLLNRFANIVVYDDNRIIlrpisghkdcphEYINACYVDGYssDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYI
. |..|  .|. .||. .|. || .|..            .|||| |.|||  . ..||||||. .|. ||| ..|... .||||.|. .. 
eitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 822-910 2.3e-16 54.5 In-house 40-138 (350) alignment 
Range on Protein: 822-910
Range on HMM: 40-138/350.0
SATVGLSSSNKllNRFANIVVYDDNRIILR----P--ISGHKDCPHEYINACYVDGY------SSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
  . |. .  |  ||. ||. |. .|..|.    .     |   . .|||| |.          .|..|||||.|. .|. ||. .. .   .||...|.
ilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

H
 
d
subfamily_PTPN14_pd Subfamily PTPN14 823-910 1.4e-17 58.7 In-house 41-127 (300) alignment 
Range on Protein: 823-910
Range on HMM: 41-127/300.0
ATVGLSSSNKLLNRFANIVVYDDNRIILRPisgHKDCPHEYINACYVDGY--SSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
 ...    |.  ||| ... |.|||. | |    |.  ..||||  .     .....||..|||. .|. ||| .||..   .|||.|..
lstaklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 823-911 2.2e-08 27.8 In-house 42-142 (349) alignment 
Range on Protein: 823-911
Range on HMM: 42-142/349.0
ATVGLSSSNKllNRFANIVVYDDNRIILR----PISGH-------KD-CPHEYINACYVD--GYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVT
 . |. .  |  ||. .|. |.  |..|.    .  .        .   ...|||| |.    .| . .||||| |.  |. ||. ..  .. .... ..
lseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

NHQ
. .
ddk
0040439 (Phosphotyrosine protein) phosphatases II 824-913 1.8e-22 75.6 In-house 4-91 (249) alignment 
Range on Protein: 824-913
Range on HMM: 4-91/249.0
TVGLSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYI
.|.|   || .||. .|. || .|..| ...|    .. |||| |.||| .  ..||||||...|. ||| ..|...  ||||.|. .. 
svallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 825-910 2.2e-23 77.7 In-house 3-86 (250) alignment 
Range on Protein: 825-910
Range on HMM: 3-86/250.0
VGLSSSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
|.   .||  ||.|.|. .|  |..| . .| |..  .|||| ...||.    .||||||...|..||| .|..|   .|||.|| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnL
0037934 (Phosphotyrosine protein) phosphatases II 826-911 8.5e-18 60.2 In-house 5-83 (243) alignment 
Range on Protein: 826-911
Range on HMM: 5-83/243.0
GLSSSNKLLNRFANIVVYDDNRIILrpisghKDcpHEYINACYVDGYSsdyQYIATQGPMSKTLVD----FWCLVWQERPPVIVMVTNHQ
.|.  |.  ||. .|. ||..|..|      ..  . |||| .....    ..||||||...|. |    || ..|...  ||||.|. .
allpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelv
subfamily_PTPRK_pd Subfamily PTPRK 827-909 6.4e-22 72.8 In-house 39-119 (314) alignment 
Range on Protein: 827-909
Range on HMM: 39-119/314.0
LSSSNKLLNRFANIVVYDDNRIILRPISGhkDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
    |.  ||. .|. ||  |..| .| |  |   .|||| ..|.|    ..|.||||. .|. ||| ||..|.   |||.|.
kkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte
0042113 (Phosphotyrosine protein) phosphatases II 827-912 1.9e-21 72.0 In-house 5-88 (245) alignment 
Range on Protein: 827-912
Range on HMM: 5-88/245.0
LSSSNKLLNRFANIVVYDDNRIILRPISGHKDCPheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQY
|   || .||. .|. ||..|..| |..|. |..  ||||.|||||    ..||||||...|. ||| ..|...  .|||.|.  .
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 828-908 3.5e-09 31.0 In-house 32-107 (285) alignment 
Range on Protein: 828-908
Range on HMM: 32-107/285.0
SSSNKLLNRFANIVVYDDNRIILrpisghKDCPHEYINACYVDGYSSD-YQYIATQGPMSKTLVDFWCLVWQERPPVIVMVT
  .|  |||.|.. . .. |..|      |.  ..|| | ..     |   ||.||||. .|| ||| ...||.   ..|. 
yeanpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 829-910 1.1e-21 72.6 In-house 23-102 (284) alignment 
Range on Protein: 829-910
Range on HMM: 23-102/284.0
SSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
  ||  ||. .|. .| |.. |... |      .|||| .. || .  .|||||||.  || ||| ..|. .   ||..|..
dqnkdknrighilafdknvvklerliGeefs..dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 829-910 1.1e-21 72.5 In-house 59-138 (319) alignment 
Range on Protein: 829-910
Range on HMM: 59-138/319.0
SSNKLLNRFANIVVYDDNRIILRPISGHKDCphEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
  ||  ||. ||. .| |.. |... |      .|||| .|.|| .  .|||.|||.  || ||| ..|. .   ||..|..
dqnkdknriinilafdknvvklerliGeefs..dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkd
subfamily_CG42327_pd Subfamily CG42327 829-910 9.2e-10 32.7 In-house 28-106 (319) alignment 
Range on Protein: 829-910
Range on HMM: 28-106/319.0
SSNKllNRFANIVVYDDNRIILRPIsGHKDcPHEYINACYVDGYS-SDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
| .|  .|..|.|   . |..|. | | .|   ||..| || ||  .. .|||.| .. ..  ||| .||. .  ||| .|. 
skdk..srvinvvPlPetrvvlqri.gddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 830-909 1.4e-18 62.0 In-house 2-78 (237) alignment 
Range on Protein: 830-909
Range on HMM: 2-78/237.0
SNKLLNRFANIVVYDDNRIILRPISGHkdcpHEYINACYVDGYSS-DYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
 ||. ||..|||.|| .|..|.   .      .||||.|..|.     .|||.|||.  .  ||| .||||.  ||||.| 
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltg
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 830-909 5.5e-18 60.0 In-house 7-85 (239) alignment 
Range on Protein: 830-909
Range on HMM: 7-85/239.0
SNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYS-SDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
 ||  ||.|||| || .|..|  .|  .|   .|||| |.  |  |   |||||| .. .  ||| ..||||  ||||.| 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 830-909 5.8e-18 59.9 In-house 6-84 (239) alignment 
Range on Protein: 830-909
Range on HMM: 6-84/239.0
SNKLLNRFANIVVYDDNRIILRPISghKDCPHEYINACYVDGYS-SDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
 ||  ||.|||| || .|..|  .|  .|   .|||| |.  |  |   |||||| .. .  ||| ..||||  ||||.| 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 830-911 3.5e-15 50.6 In-house 32-111 (297) alignment 
Range on Protein: 830-911
Range on HMM: 32-111/297.0
SNKLLNRFANIVVYDDNRIILRPISGHKDcpheYINACYVD--GYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQ
|    ||. .|. .||.|. |.     .|    |||| ||      .|..|| .|||.|.|. ||| ||...   |||||.. |
sslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq
Y_phosphatase Protein-tyrosine phosphatase 831-910 9.3e-23 76.2 Pfam-A 1-76 (235) alignment 
Range on Protein: 831-910
Range on HMM: 1-76/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|. 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsl
Y_phosphatase Protein-tyrosine phosphatase 831-910 9.3e-23 76.2 In-house 1-76 (235) alignment 
Range on Protein: 831-910
Range on HMM: 1-76/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpheYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|. 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsl
0041856 (Phosphotyrosine protein) phosphatases II 831-914 5.7e-14 47.6 In-house 1-72 (182) alignment 
Range on Protein: 831-914
Range on HMM: 1-72/182.0
NKLLNRFANIVVYDDNRiilrpisghkdcPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYIF
|. .||. .|. || .|            .  |||| ...|.  . ..||||||. .|. ||. ......  .||..|...|  
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 831-907 6.7e-08 26.4 In-house 34-107 (332) alignment 
Range on Protein: 831-907
Range on HMM: 34-107/332.0
NKLLNRFANIVVYDDNRIILRPISGHKDcpheYINACYVDGYSSDYQYIATQGPMS-KTLVDFWCLVWQERPPVIVMV
|  .||   . ..| .|. | |  |. |    . || .|||||    || .| |.  .|   || .| . .| .|...
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 832-910 7.5e-20 66.1 In-house 29-107 (274) alignment 
Range on Protein: 832-910
Range on HMM: 29-107/274.0
KLLNRFANIVVYDDNRIILRPISGHKDcPHEYINACYVDGYSSDY-QYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
.  ||. .|.  .  |..|.. |....   .|||| |. ||. .   |.|||||...|. ||| ...||. .||||.|. 
qtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 833-909 1.4e-19 65.0 In-house 40-113 (287) alignment 
Range on Protein: 833-909
Range on HMM: 40-113/287.0
LLNRFANIVVYDDNRIILrpiSGHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTN
  ||.|... .||.|..|   | . .   .|||| || .|  | ..||.|||.. |. |||..|...|  .....| 
kknryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 834-908 4.1e-10 33.8 In-house 59-126 (290) alignment 
Range on Protein: 834-908
Range on HMM: 59-126/290.0
LNRFANIVVYDDNRIILRpisghKDCPHEYINACYVDGYSSdyQYIATQGPMSKTLVDFWCLVWQERPPVIVMVT
 ||. ..|  |  |.||.        . .|. | ||.|  .   .| |||.. .| .|.| .| ||.  .|||. 
knrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlc
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 834-922 6.5e-08 26.5 In-house 40-128 (347) alignment 
Range on Protein: 834-922
Range on HMM: 40-128/347.0
LNRFANIVVYDDNRIILRPIS---GHKDCPHEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQyifINDAVLEF
 ||  .  . |. |..| |     .. | .. |||| ..    .. .|| || |. .|. ||| .|   .   .| . . .    ..|. ||
knrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi...kdeaieef
0046846 (Phosphotyrosine protein) phosphatases II 858-911 1.3e-07 27.0 In-house 9-58 (176) alignment 
Range on Protein: 858-911
Range on HMM: 9-58/176.0
DCPHEYINACYVDGYssdyQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQ
| .  |||| ...|.     .||||||. .|| ||. ......  ..|..|...
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteev
0043147 (Phosphotyrosine protein) phosphatases II 861-914 5.3e-11 38.0 In-house 5-58 (172) alignment 
Range on Protein: 861-914
Range on HMM: 5-58/172.0
HEYINACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYIF
. |||| |.|.|    ..||||||.. || ||| .....   .||..|...|. 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydp
0036282 (Phosphotyrosine protein) phosphatases II 861-913 2.1e-07 26.3 In-house 2-49 (174) alignment 
Range on Protein: 861-913
Range on HMM: 2-49/174.0
HEYINACYVDGYSSDYQYIATQGPMSktlvdFWCLVWQERPPVIVMVTNHQYI
. |||| ..|..     .||.|||..     || ......  ..||... .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekel
0051429 (Phosphotyrosine protein) phosphatases II 862-916 1.8e-08 29.9 In-house 5-61 (272) alignment 
Range on Protein: 862-916
Range on HMM: 5-61/272.0
EYINACYVDGYssdYQ------YIATQGPMSKTLVDFWCLvWQERPPVIVMVTNHQYIFIN
 |||| .|.||   ..      .....||.  |  ||| | ....  .||....  ..  .
gyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 864-910 4.3e-06 20.7 In-house 78-124 (301) alignment 
Range on Protein: 864-910
Range on HMM: 78-124/301.0
INACYVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNH
| | ...      ..||||||...|  ||| .. |     |||....
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqk
0049260 (Phosphotyrosine protein) phosphatases II 868-914 2.8e-07 25.8 In-house 1-47 (152) alignment 
Range on Protein: 868-914
Range on HMM: 1-47/152.0
YVDGYSSDYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQYIF
..|||   ...||||||.. || ||| ....    .|||.|..... 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 875-912 8.3e-07 23.4 In-house 4-41 (199) alignment 
Range on Protein: 875-912
Range on HMM: 4-41/199.0
DYQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQY
. .||||| |. .|. ||| .||.     |||| . | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 876-912 9.8e-07 23.1 In-house 4-40 (198) alignment 
Range on Protein: 876-912
Range on HMM: 4-40/198.0
YQYIATQGPMSKTLVDFWCLVWQERPPVIVMVTNHQY
 .||||| |. .|| ||| .||.     |||| . | 
rryiatqhplretladfwqmvwetgsghivmvnddqk
subfamily_PTPRD_pd Subfamily PTPRD 908-1001 1.8e-15 51.6 In-house 266-360 (564) alignment 
Range on Protein: 908-1001
Range on HMM: 266-360/564.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQFTVLQ-QVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGE
|..||||| .|.||.. ||||...| . .. . ||.|....|..||.|  |  |.  . ....| .    ..||.||| .. |. .. || |. .
teeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsai
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 908-959 3.5e-08 27.9 In-house 265-316 (318) alignment 
Range on Protein: 908-959
Range on HMM: 265-316/318.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQFT
|..||.|| |..||....|.|..|. . || | .| |||||.|.|  . .| 
tedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 908-958 1.1e-07 26.2 In-house 268-318 (319) alignment 
Range on Protein: 908-958
Range on HMM: 268-318/319.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQF
...||.|| .|.||.| .|.|.|.  . |  . .|.|....||.|| | .|
rpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
subfamily_PTPRK_pd Subfamily PTPRK 908-958 8.2e-06 19.8 In-house 262-312 (314) alignment 
Range on Protein: 908-958
Range on HMM: 262-312/314.0
TNHQYIFINDAVLEFVMCGNTQIDSWQARSMIGKLSEQDPETGQTGYEEQF
|. ||.|| |..|| ..||.| |   . ...  . .. ||.|  .  .|.|
teeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef
0050432 (Phosphotyrosine protein) phosphatases II 912-1218 3.5e-74 245.2 In-house 1-307 (308) alignment 
Range on Protein: 912-1218
Range on HMM: 1-307/308.0
YIFINDAVLEFVMCGNTQIDSWQARSMIGKLSE-QDPETGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLkGEHPDYINAVF
|..| ||.||......|.|  .  . .. .| .  .. .. ...||.|  |..|.  . | ..    .||||||.. .|| |. || | .|. ||||| .
yllildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsy

INGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS---GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIrL
..||  | ...||.. .|. ||  .||.|. . ||. ||||. . | ... |.||||..   ||...| ....| .|. ...|. ||.|..|...    .
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.r

SVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
 | ... |||   |   .|. .| ..|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||. ||. ....
tvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

VLAYLDSFQTYSN
.| || ...|. |
lleylklkltkln
0039614 (Phosphotyrosine protein) phosphatases II 913-1213 3e-65 215.9 In-house 2-292 (297) alignment 
Range on Protein: 913-1213
Range on HMM: 2-292/297.0
IFINDAVLEFVMCGNTQIDSWQARsmigklseqDPETGQTGYEEQFTVLQQVTQkpDeVTHNIASQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYIN
... ||.||..... . .| .. .         .. .. |.....|  |....   |  ..    .||||||.. .|| |. || ||.     .. ||||
lplrdallesipiplsvldlllll.........ekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYin

AVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQqACYQYWPSSGSvVIGEYFIELENETRNNGYIERTFEIKNSNKTairLS
| ...||.  ...||..  |. .|  .||.|. . .||.||||. ..||..  |.||||..|. . |.....| ... ..||. ||.|..|....   . 
AsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges...rt

VVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
| ..| |.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|||  ||. ....
vthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda

VLAYLDSF
.| .|  .
llellkrk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 926-1216 4.5e-72 237.8 In-house 1-296 (298) alignment 
Range on Protein: 926-1216
Range on HMM: 1-296/298.0
GNTQIDSWQARSMIGKLSEQDPETGQTGYEEQFTVLQQVTQKPDEVTHNIA--SQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKA
|||.|.. . . .. ||.. ..... |||...|  |..|... .| ....|  ..||.||| .. .. |  || |.     |. |||||.|...||...|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTaIRLSVVQYQITNWDSTG
||... |. .|  .||.|. ......||||   .||..  . .|||..|.   ||  ..| .. .   .| |..........  . .|.| . |.| . |
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkg

EVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTY
. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| .||  | ..|| .||||...
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_PTPN6_pd Subfamily PTPN6 933-1215 6.1e-46 151.8 In-house 7-302 (306) alignment 
Range on Protein: 933-1215
Range on HMM: 7-302/306.0
WQARSMIGKLSEQDPETGQTGYEEQFTVLQQVT-QKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEHPDYINAVFINGY--KEKKAFIIAESP
 . .. . .|.... .....|.||.|  |||   .|  . ..    .|| |||    || |. || ||       ||||| .|..   ...|..| ..  
keieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgc

MFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGS-VVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQ
. .|  .||.|. . | . |||. .|.|  .. |..|||.. .    |.. ..  .|.... || |.. ... .|     .|.||. ..|   |  |.|.
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg

TILMIMEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
..|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| .||  . ... .|... ..
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
0045450 (Phosphotyrosine protein) phosphatases II 936-1210 3.1e-66 219.5 In-house 11-304 (307) alignment 
Range on Protein: 936-1210
Range on HMM: 11-304/307.0
RSMIGKLSEQDPETGQTGYEEQFTVLQQVTQK-PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYINAVFI--------NGYKEKKAFI
. .. .|  ... .. ||....|  |..|| . ..| ..    .||||||.. .|| |. || |.      |. ||||| ..        .||. |..||
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

IAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSV-VIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGE
.. .|. .|  .||.|. . .||.||||... ||... |.||||..|.. ..|.....| .|.  .||. ||.|......|   . | ... |.|  .| 
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

VKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
 ......| ..||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||.  ||. .....| .|
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 938-1219 6.6e-158 519.1 In-house 6-287 (287) alignment 
Range on Protein: 938-1219
Range on HMM: 6-287/287.0
MIGKLSEQDPETGQTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKM
..|.........|..|...|||||.||||..||||||||||||||||.||.|.||||||.||||||||||||||.||||||||||||||||||||||||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRT
|||||||||||||.|.| ....||||||.. |||.||| ||| ||..|.|||||..|.||.||.. ...|.|||||||||||.|..|||||...||||.|
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSNF
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||..|..|||.|||||.|||.|
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 938-1211 1.2e-20 68.5 In-house 8-288 (305) alignment 
Range on Protein: 938-1211
Range on HMM: 8-288/305.0
MIGKLSEQDPETGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWK
 | |. ..  | | .|  ..|. .... .  . .     .|...|||  .    || || |.|  | .|| | ..    . | || ...|. .|  .|| 
qilkfvkrtlekgpaglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwy

MIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVI----GEYFIELENETRNNG--------YIERTFEIKnSNKTAIRLSVVQYQITNWDSTGevkNP
|  . .| || |||   |   . |..|..|    |.    ..  | .  |. ..          ...|  .      .  . | .|   .|   |    |
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvi.egpgekarkvthyhwidwpdrg...vp

QTILMIMEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
 . | |.| . ...  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| .||  . |..| |. 
aadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0051299 (Phosphotyrosine protein) phosphatases II 941-1210 2.4e-71 235.9 In-house 16-286 (288) alignment 
Range on Protein: 941-1210
Range on HMM: 16-286/288.0
KLSeqdpETGQTGYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWK
||      .|.||..|.|  |.... .  .... .  .|..|||.. .|| |. || |.     |. ||||| .|.||. |..||... |. ||  .||.
kll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSN---KTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEE
|. . ||. ||||. . ||... |.||||..||...|.....| .|. ...|. ||.|..| .   ..   . | ... |||   |   .|. .| ....
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

MYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||. ||. .....| ||
vrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 944-1217 1.1e-124 410.0 In-house 12-290 (290) alignment 
Range on Protein: 944-1217
Range on HMM: 12-290/290.0
EQDPETGQTGYEEQFTVLQQvTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK--GEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKM
...  .|..|...||..|.. .... .||....|.|| .||.......|..|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRT
|....||.||||....| ... |.||||.|..  .||. |.| ||.  |.||||..|.||.|... . ||.|||||||||||.|.||||||...||||.|
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYS
|||||||||||||||||||||.||||||||||||||||||||||||||||||||||||| ||.||.|||| |||||.|||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 945-1212 3.5e-50 165.7 In-house 8-278 (281) alignment 
Range on Protein: 945-1212
Range on HMM: 8-278/281.0
QDPETGQTGYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDD
|  .  ..|. |... |... .. .  |   | .|. ||| .     |. || .    . .. ||||| |..|||..|..|....|. ..  .||.|. .
qlsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

RNVTAIVMLCHENELKQQACYQYWPSSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAirLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQR
..|.||||. .| |  .  |..|||    .. .|.. .. ..|.... ||||.|......  .   .|.| . |.|  .|  .... .|   .|......
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresget..reveqlaytaWPdhGvPattkellefrkevlklte

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   ||||.||| . ..|| .|| 
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 945-1206 1.9e-49 163.7 In-house 27-287 (319) alignment 
Range on Protein: 945-1206
Range on HMM: 27-287/319.0
QDPETGQTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDD
.| .  .| .| .|  . ... .  . |.    ||||||| .. |. |. .| |.   | |  ||||| |..||. |. .| |  |. ||  .||.|| .
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

RNVTAIVMLChenelkQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEE-MYRTQR
 |...||.|       .. | ||||  . .  ... ....  .  . |. | .|. .  |     .. |. .  |   |  . |  ......   . |..
yncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
......||||||  |||. .. .  . ... | |  .||.....  | |..  || ..||  |   .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
0047943 (Phosphotyrosine protein) phosphatases II 946-1210 1.2e-69 230.1 In-house 6-272 (273) alignment 
Range on Protein: 946-1210
Range on HMM: 6-272/273.0
DPETGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
.. .| |...|.|  |....  . . .. .  .||||||.. .|| |. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCHENELKQQACYQYWPSSG---SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAiRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-
||||. . ||... |.||||..|   |.. |.....| .|. ...|. ||.|..|..     . | ... |.|   |   ... .| ..|.. .....  
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
.|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||. ||. .....| ||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN9_pd Subfamily PTPN9 947-1209 3e-41 136.4 In-house 11-289 (297) alignment 
Range on Protein: 947-1209
Range on HMM: 11-289/297.0
PETGQTGYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |.|. |  .... ... . .  ....     |  ||| |  |  |. || |.     |. ||||| |..|||.||||| .  |. .| ..||.|. ...
kekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

VTAIVMLCHENELKQQACYQYWP--SSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQR-
|  |||  .  | ..  | ||||  .  |   |.. ..  .   .. | .|..||||...  .| .|. .|.. |   |  .. ...| ..|.. ..|  
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaaslldvlekvrekqal

--------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
        ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||  |||   . || |
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN23_pd Subfamily PTPN23 948-1210 3.8e-49 162.0 In-house 11-280 (288) alignment 
Range on Protein: 948-1210
Range on HMM: 11-280/288.0
ETGQTGYEEQFTVLQQVTQKP-DEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTA
  |.|. ...|  |.|  .|   . .  ||  . .||||.  || |. || |.|.. ||||| |...       ||.. .|. .|.  ||.|. .. .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEM---YRTQRK
|||| ...||... . .|||..   .|. |.. . |..... . ..||.....  .. |.. ||.  |.|.| . |  . |.|.| ...|.   |.....
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavk.svshlqltsWpelGvPasPetllqfldevesayeavqr

RGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
. .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||...|..   ..|| . 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN12_pd Subfamily PTPN12 948-1210 9.6e-48 157.5 In-house 4-277 (290) alignment 
Range on Protein: 948-1210
Range on HMM: 4-277/290.0
ETGQTGYEEQFTVLQQVTQKP--DE---VTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
..|.  ....|. |.....|   ..    ..  ...|. |||    || |. || |.     |. ||||| ||.| ..|...| | .|. .|  .||.||
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

DDRNVTAIVMLCHENELKQQACYQYWPSSGSVV--IGEYFIELENETRNN-GYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEVKNPQTILMIMEEMy
.. ||. .||.|.| ||... | .|||..|     .||. ..||.| . . ... ||.........    .| |.. |.|   |  ......| ..|.. 
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielv.

RTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
|. ... .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||  ||| . . |. ..
relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 949-1215 4.1e-72 237.9 In-house 19-288 (305) alignment 
Range on Protein: 949-1215
Range on HMM: 19-288/305.0
TGQTGYEEQFTVLQQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. ..|.|.|.  |..  ... .|... |...|....... |..| ...  | ...  ||||| ...|||.||..|.| .|. || ..||..| .  |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCHENELKQQACYQYWPSSGSV--VIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT
|||..  | ... |.|||| | .    .||. .||..|.  ..|||| ..| . ..     .|.|||.|.|   | .. . ..| ..... ..|.|  ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
...||||..|||. .|.|    ....|.|.|.|||.|||  | .... |||  ||  . ...  .. ...|
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
0036941 (Phosphotyrosine protein) phosphatases II 949-1215 3.1e-68 225.6 In-house 10-282 (297) alignment 
Range on Protein: 949-1215
Range on HMM: 10-282/297.0
TGQTGYEEQFTVLQQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
.. ......|  |...   . . .. .  .|..|||.. .|| |. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||| |||
lflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LCHENELKQQACYQYWPSS--GSVVIGEYFIELENETR--NNGYIERTFEIKNSnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GN
|. . ||  . |.||||.   .|.. |.....| ...   ...|. ||.|...  ..   . | ....|.|.  |   .|...| ..|.. . ...  ..
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
. ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||. ||. .....| .| .. |
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 949-1215 1.5e-59 196.6 In-house 20-288 (319) alignment 
Range on Protein: 949-1215
Range on HMM: 20-288/319.0
TGQTGYEEQFTVLQQVTQKpdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
||.|. |..|  |.. ...  ....    .||.||| .. |. |. || |.     |  ||||| ||.||.|...|| . .|. ||  .||.|. .... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

AIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT
 .|||.. .|  .  . .|||.   .. |.. ..||.| . ..|| | ..... .      .|...| |.|   .  .. ...| ..... ....|  . 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
 ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.  ||. | ...|.......|
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 949-1216 2.2e-52 172.9 In-house 18-287 (288) alignment 
Range on Protein: 949-1216
Range on HMM: 18-287/288.0
TGQTGYEEQFTVLQQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
...||..|.. .| .. .| ..||    ..|..|||  . || |  || ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... .....
rnrtgfseeynsLaal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

AIVMLCHENELKQQACYQYWPSSGS-VVIGEYFIELENETRNNGYIERTFEIKnsnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRgN
 |||| .  |  .. | .|||...  .  |.  ..| ..   . ...|.....   |.  .| . ||| . |  .|  .. . .| ... .  .. .   
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL--AYLDSFQTY
  |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||..||| | ...|  .. |. ...
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgvaev
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 950-1218 3.2e-64 212.0 In-house 18-288 (318) alignment 
Range on Protein: 950-1218
Range on HMM: 18-288/318.0
GQTGYEEQFTVLQQVTQKPDEvTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
|.. ..|..  |....... . .. . . || ||| .  |. |. || |.     |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| . 
Gelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTS
|||| .|.|  .. . .||||.||  .|.  .||..|.. . |. |.|....... . |  | ||..|.|  .|  ... ..| .. .  ..|.| |.. 
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
||||||  |||  .|.|  . ... | |...||||. |  | |..  |||  ||| | ...| .| |..|. .
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0043336 (Phosphotyrosine protein) phosphatases II 950-1209 1.6e-63 210.1 In-house 18-276 (278) alignment 
Range on Protein: 950-1209
Range on HMM: 18-276/278.0
GQTGYEEQFTVLQQVTQkpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
..|.....|  |....   |. .. .  .||||||.. .|| |. || |. .      ||||| ...||. ...||..  |. .|  .||.|. . .|| 
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLCHENELKQQACYQYWPsSGSVVIGEYFIELENETRNNGYIERTFEIKNsNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTS
||||. . ||... |.|||| .||...|.....| .|. ...|. ||.|..| ...   . |..|. ..|   |   .....| ..... . ..   |. 
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngp

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.|||  ||. .....| |
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRG_pd Subfamily PTPRG 950-1214 1.1e-52 174.0 In-house 17-291 (563) alignment 
Range on Protein: 950-1214
Range on HMM: 17-291/563.0
GQTGYEEQFT-VLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
|..|..|.|  . .....|  ...|  . .|| ||| .. .. |. || |.   |..   ||||| .|.||. .||||..  |. .|.  ||.|| ..||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TAIVMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNS-----NKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQ
. |||.   .| ... | .|||. .|. .|.  . |..| .   | .||. |||      ...   . | ||. |.|  .|  . .   |. ..   ...
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

RKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQ
..     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||  ||  . ...|  . | .
ka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_PTPRB_pd Subfamily PTPRB 950-1212 1.9e-49 163.3 In-house 23-287 (293) alignment 
Range on Protein: 950-1212
Range on HMM: 23-287/293.0
GQTGYEEQFTVLQQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
 .... |..  |..| ..  .|. . ...|..||| |. || |. || |    . .. ||||| .|.||. .. || .  |. .|  .||.|. ......
sdlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLCHENELKQQACYQYWPSS-GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTairLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQ-RKRGN
|||| .  |  .. | .|||.   .|. |.  ..| .|.. . .. |...|......    .| ||. | |   |  ....|.| ..... ... ..  .
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekee...rkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||..||  | | ||..| .
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 950-1208 5.4e-30 99.2 In-house 18-277 (439) alignment 
Range on Protein: 950-1208
Range on HMM: 18-277/439.0
GQTGYEEQFTVLQQVtqKPD-EVTHNIASQ--NKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |  ..| |  .. .  .|| ..  ..|.|  .. |||  .  . |  || |       |  |||| .|.|| ..| .| .. |  .|. .||... ...
kqeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

VTAIVMLCHENElkqqaCYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR
.. ||||.   |      |.||||.. |. |.  .  . .     |. | | . |    |    .|.|.. . |       .   .|  .  .  .. |.
tvtivmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLA
    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  | . || 
eygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 951-1207 1.1e-66 219.7 In-house 5-263 (283) alignment 
Range on Protein: 951-1207
Range on HMM: 5-263/283.0
QTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
..... .. ||....  . ... . |..|| |||  . .| |..|| || | .||||||||     ||..| .||| ||. .| ..||||. |...||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKnPQTILMIMEEMYRTQRKRGNTSIV
|| .  | ....| ||||. ||.  ||. . |..|| .| .| . . ..... .   | .  ||. .| . ||   .   |. .. .   |..  .. ||
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskkgPiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
|||| ..||.|.|.||...... .|| |.|||.|.|  | |... |||  ||  . ..||
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 951-1218 7.2e-65 213.6 In-house 14-301 (301) alignment 
Range on Protein: 951-1218
Range on HMM: 14-301/301.0
QTGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
....|||.. |.....|. .|... . .. ....... .. ..  .  |      . .|||| .|.||.|||.||.|..|| .| ..||..| .  ...|
snkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLCHENELKQQACYQYWPSSGSVVIGEYFI--ELENET-----------------RNNGYIERTFEIKNSNktaIRLSVVQYQITNWDSTGEVKNPQTI
||.. ..| ... |.||||.|      ....  .| ||.                  |||||||.|..|...      .|.|.|.|.|   | |..|.|.
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtv

LMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
|......  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  ||  | ...  ||   .||.|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Ptp69D_pd Subfamily Ptp69D 951-1211 1.1e-53 177.3 In-house 21-287 (307) alignment 
Range on Protein: 951-1211
Range on HMM: 21-287/307.0
QTGYEEQFTVLQQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. |... .  |..  . . . .      |. |||. .  . |..|| ||     |. ||||| ||.|||||| ||.|  |. .|. .||.|| . .|| |
dfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTA----IRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRg
|||  ..| ... | .|||    |  |.  ..| .| . . ||.|.... . ....     .  ||||. |.|. .   . ....| ..|...  ...  
vmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
.. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||   ||. . . .| | .
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 951-1208 5.4e-44 145.6 In-house 22-286 (325) alignment 
Range on Protein: 951-1208
Range on HMM: 22-286/325.0
QTGYEEQFTVLQQVTQKpdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAI
| |.  .| .|  .  .    .     .||.|||    .. |. || |.      . ||||| ... .|.|. |. | .|. .|  ..|... | . ...
qdgfahefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csv

VMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIrLSVVQYQITNWDSTGEVKNPQTILMIMEEMYR---TQ--R
|..  | .|... | .|||     |.  |   ..|        |. | ...|. .|    .|| |.|.  ||  |  | | |.. |.. .     .    
vvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGet.rsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLA
 .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| ||  | . .  
tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 952-1205 5e-43 142.0 In-house 6-254 (267) alignment 
Range on Protein: 952-1205
Range on HMM: 6-254/267.0
TGYEEQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
. .|..|  .......   ..  ||..|...||  . || |. ||.|. .  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| .
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

ENelkQQACYQYWPSS-G-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYqiTNWDSTGEVKnpQTILMIMEEMYRTQRKRGNTSIVVH
     ..   ..||   | .    .  .|   |  .| |   |.|.|  |..|  ...  |   .|.   . |    .  ..  . . | . ||  .||.
vf...tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyy..kkwnintnnk..pylkplfgilaknqlengnrPlvva

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
||| ||||  |  . . ... ||||| |.|. |.  | |..| |.|  .|  | ..
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
0040438 (Phosphotyrosine protein) phosphatases II 953-1212 1e-66 220.7 In-house 19-278 (317) alignment 
Range on Protein: 953-1212
Range on HMM: 19-278/317.0
GYEEQFTVLQQVtqKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
. .|.|  |...  |.|. .. .  .||||||.. .|| |. || |. .      ||||| ...|...|..||.. .|. ||  .||.|. . .|| |||
alleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LCHENELKQQACYQYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVV
|... ||... |.||||. .....|.....| .|. ..|.. ||.|.... ..   . | ... |.|.  |  ..|...| ..|.. . .. .... ..|
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlV

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
|||. |||...|.|| . .. ...|| .||....|  | |.||.|||  ||. .....| ||  
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_egg_pd Subfamily egg 953-1210 4.6e-19 63.2 In-house 15-270 (307) alignment 
Range on Protein: 953-1210
Range on HMM: 15-270/307.0
GYEEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
..| .. ||......   .|. ... |..| || .    |  || |.   | .  |.| |  ..|      ||.|..|. ||  .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCHENELkqQACYQYWPSSG--SVVI--GEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQiTNWDSTGEVKNPQTILmimeemyRTQRKRgNT
|    |   . |  ||| .   |.|.  | . ||  .  ..   . |  ..|        . .  .|  ... ...|  |  .|       |  |.   .
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvl.......rklrnl.sk

SIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVTQYEGICQIVLAYL
 .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..| .|  . ..|| ..
pvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 954-1210 5.1e-26 86.4 In-house 18-277 (307) alignment 
Range on Protein: 954-1210
Range on HMM: 18-277/307.0
YEEQFTVLQQvtQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK--GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
  ..|.|| .  ..|. || .  | | |||| ..    |. |. .|  |   ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.
lvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

ENELKQQACYQYWPSSGS--VVIGE--YFIELENET-----RNNGYIERT-FEIKNSNKTairLSVVQYQITNWDSTGevkNPQTILMIMEEMYRTqRKR
  || .  | ||||       | ||    | ..|        .. .|. | .... ..|.    .. ..| .||   |    ||. |  .. .  . |  
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqks...rtiqhlqwenwpdrg...vpqinltainlleav.ryd

gNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
 .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  ||  . ...| |.
.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 954-1210 4.9e-19 63.0 In-house 29-290 (310) alignment 
Range on Protein: 954-1210
Range on HMM: 29-290/310.0
YEEQFTVLQqvTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
   |.  |.  ...   .|..   ..  ||| .. .  |. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    .|..||
lvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

HENELKQQACYQYWPSSGSVVIgEYFIELENETRNN-----GYIERTFEIKNS--NKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGN
.  |  .  |  |||| |        | . | .          .  ||   |   ..    |  .. .. .|    .   |.     . .   .| . | 
kvgeegrpkcvgywpslgvtet.ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgp

tsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
   |||||  ..|  . .|   .|.| .    .|. .|    . ..   .||  ||  | .. ... 
..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa
0046845 (Phosphotyrosine protein) phosphatases II 955-1218 1.6e-68 226.4 In-house 3-282 (284) alignment 
Range on Protein: 955-1218
Range on HMM: 3-282/284.0
EEQFTVLQQVTQKPD-EVTHNIASQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNV
||.|  |...| |.  .... .. .|..|||....|| |. || ||      |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TAIVMLCHENELKQQACYQYWPSSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRK-R
. ||||. . | ... |.||||..| ....|.....| .|. ...|. ||.|..| . |   . | ....|.|   |   .|. .| ..... . ...  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
|.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. ||. .....| || .. |. .
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
DSPc_SM00195 955-1210 2.4e-64 212.6 In-house 3-262 (263) alignment 
Range on Protein: 955-1210
Range on HMM: 3-262/263.0
EEQFTVLQQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |..  |.|... ..||.|||....|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENELKQQACYQYWPSS--GSVVIGEYFIELENETRNN-GYIERTFEIKNSNKtAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIV
 |.| ... |..|||..  |. ..|.. ..| ...  .  .| ||.|... .|     .| |||..||   |  .... .| ...... ....  .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||  |....|.|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 955-1210 2.4e-64 212.6 In-house 3-262 (263) alignment 
Range on Protein: 955-1210
Range on HMM: 3-262/263.0
EEQFTVLQQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |..  |.|... ..||.|||....|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENELKQQACYQYWPSS--GSVVIGEYFIELENETRNN-GYIERTFEIKNSNKtAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIV
 |.| ... |..|||..  |. ..|.. ..| ...  .  .| ||.|... .|     .| |||..||   |  .... .| ...... ....  .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||  |....|.|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 955-1212 1.6e-39 130.8 In-house 14-271 (273) alignment 
Range on Protein: 955-1212
Range on HMM: 14-271/273.0
EEQFTVLQQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
.|.|. |...  . |...     .||||||  . || |. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

NELKQQACYQYWPSSGS--VVIG-EYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVH
 | ..  | .|||.| .  ...   . .||.. .. .|.  |....|.|. .. |  |.. . ..|   |  .... .| .. |. | |.   .. ||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesr.evahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDS
||  .||| .. .  . ..  . .  .|| ..... | |. | |||  ||  . ...|  | |
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 955-1210 1e-18 61.8 In-house 29-285 (302) alignment 
Range on Protein: 955-1210
Range on HMM: 29-285/302.0
EEQFTVLQQVTQKPDEvtHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCH
...|  ....  . ..   ..  .| .||.|...  .|. .| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  
kkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg

ENELKQqACYQYWP-SSGS-VVIGEYFIELEN-ETRNNGYIERTFEIKNSNKTAIRLSVVqYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVV
|.|||. .  ...|  ||. .  |. |.     |  ..   . . |.   . .   |. | | .||| ..   ..  ..   .....  .   .. ..|.
eeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv.yvltnWkqkkvpvkyaeliktaakvfakk.ikadentvi

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
     .|| ..| ..|....| ...    . ...|| | |.| .|....||  .  ..| |.
vSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_PTPRN_pd Subfamily PTPRN 956-1206 5.8e-36 118.7 In-house 33-288 (297) alignment 
Range on Protein: 956-1206
Range on HMM: 33-288/297.0
EQFTVLQQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGE----HPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
...  | .  ..|   .   | .| .||||...|| |. || || |    . ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

HENELKQQACYQYWPSSGSVVIGEYFIELENET-RNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGnTSIVVH
. .|   ..|..|||  || | . | ..|  |    . |. |.| .|| ...  | .| |.    | ..|   .....|     . .. | |  ..||||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvh

CSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
||| .||. ....    .|.  |    ||.   |.  | |.|| |.|  |.| . . |
csdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_ptpA1_pd Subfamily ptpA1 956-1170 5.2e-20 66.5 In-house 25-256 (418) alignment 
Range on Protein: 956-1170
Range on HMM: 25-256/418.0
EQFTVLQQvTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
|.| .|.. .  | | .     .|  ||| |. || .  || ||     |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .
eefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsr

ENELKQQACYQYWPS-----------SGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRK
|.|  .  | .|||             |  |.| | .|| .  ..      | .|. . .   |  . |||   |         | .  ..  .   | .
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr.ditqyqyegwpdhnipdhtqpfrqllhsitnrqnq

-----RGNTSIVVHCSDTVGRSAMFCAAATTINKC
       |  |.||||  |||.  ||.|   ..| 
iipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_CG42327_pd Subfamily CG42327 956-1134 6.4e-18 59.5 In-house 9-190 (319) alignment 
Range on Protein: 956-1134
Range on HMM: 9-190/319.0
EQFTVLQQVTQKPDevthNIASQNKDKNRSTQF--LPPDNYRVPLKGEHP--DYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLC
|.|  | |.  . |    ..    |||.|  .   ||. .  .. .|...   |..| .. ||.. .. .| |. .. ... .||... ...   || |.
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

HENELKQQACYQYWPSS----GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQItNWDSTGEVKNPQTILMIMEEM
   ||  . | .|.|..    .  . |.. . | .   .. |.  |. .|. .|   |  .  |   .|  ..   ...... .. |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleaevPaeeaaliamllev
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 959-1085 1.1e-07 25.5 In-house 65-171 (349) alignment 
Range on Protein: 959-1085
Range on HMM: 65-171/349.0
TVLQQVTQKPDEVTHNiASQNKdknrstqflppdnyrvplKGEHPDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELK
 .|..  . .  . .   |. .                   |   ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|| 
vklkkslksskvikas.tsesd..................sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

QQACYQYWPSSGsvvIGEYFIELENETRN
 . |..||         .. . | |   .
lekcdiywqels...ysnitvklqnssly
subfamily_PTPN1_pd Subfamily PTPN1 961-1200 4.9e-36 118.9 In-house 12-261 (290) alignment 
Range on Protein: 961-1200
Range on HMM: 12-261/290.0
LQQVTQKPDEVTHN--IASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQ
....... ......     .|...||     | |  |. |. .. ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  | .|.
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

ACYQYWPSSGS---VVIG--EYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQR-KRGNTSIVVHCSD
 |.||||.  .   ...   .. ..| .| |.. |. |..|..| .    | .....  | |   |  . |.. |  . .. ..   ..     |.||| 
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetr.eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

TVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYE
 .|||  || . | .    | .    .|. .||   | .. | .||  | .
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_PTPN14_pd Subfamily PTPN14 961-1211 5.7e-32 105.9 In-house 29-297 (300) alignment 
Range on Protein: 961-1211
Range on HMM: 29-297/300.0
LQQVTQKPDEVTHNI--ASQNKDKNRSTQFLPPDNYRVPL---KGEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEN
 .....|  . . .     .|..|||  ..|| .. || |   | .. .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| .|.
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

ELKQQACYQYWPSS----GSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT-----
|  .. ...|.|..     .|  |.. .  .  .  . .| .....|       | .|.  | |.|   |  ..... |  .||.   .||  ..     
edgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer.tvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

---SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
    ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||..||. . .... ||.
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 961-1198 7.2e-27 88.9 In-house 32-269 (301) alignment 
Range on Protein: 961-1198
Range on HMM: 32-269/301.0
LQQVTQKPDEVTHNIASQNKDKNRSTQF--LPPDNYRVPLKGEHpDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQ
..  | . |..|.  |  .|||.|  .    |    .|  .|.    | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... | ...
vnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkveklee

ACYQYWPSS--GSVVIGEYFIELENET--RNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEeMYrtqrKRGNTSIVVHCSDTV
 | .| |..   .. || . |...|.    |.  ..||.|...| .     .|. || ..|   |  |    .  .|| .     |. .  ||||||. .
kceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lv....kksekPivvhcsaGi

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQ
|||  | ..    .. ...  |.. . ||  | ..  .|||..|
Grsvafigteylareveadptieltealkhlrehrwngvqtnsq
0045098 (Phosphotyrosine protein) phosphatases II 962-1210 4e-61 202.2 In-house 16-272 (278) alignment 
Range on Protein: 962-1210
Range on HMM: 16-272/278.0
QQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPlkgehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACY
. ..  |.|.|...   |.|||| ...|| |. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... ||... |.
llllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPSSGSVVIGEYFIELENETRNNGYIERTFEIKNS---NKTAIRLSVVQYQITNWDSTGEVKNP--QTILMIMEEMYRTQR------------KRGNT
||||..||...|.....|..|.... |. ||... |     ..   . | ......|.  |   .|  . .| ..|.. . ..              ...
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

SIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVTQYEGICQIVLAYL
 ..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||.  ||. ... .| .|
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 964-1202 3.9e-10 33.8 In-house 32-271 (303) alignment 
Range on Protein: 964-1202
Range on HMM: 32-271/303.0
VTQKPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKgeHPDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQY
|.  | .|..|   .| |||| .. .  |  .| |      || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| ..      
vsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSSGSVV-IGEYFIELENET---RNNGYIERTFEIKNSNKTAIrLSVVQYQITNWDSTGEVKNPQTILMIMEeMYRTQRKRGNTSIVVHCS-DTVGRSA
.|     . . | .| . .       .|.  .   . | .  .. | | .|.    .|     .|. .  | . .    ||  ...  |. |   .||. 
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksf.lhvhhykawphnsipsdgspkfvkqiwq.lqsvlrkysdstptvymslsgcgrag

MFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGI
 |.   |.     . .  .|. ..|.  |  .  .|| ..|.  .
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 966-1209 1.8e-27 90.8 In-house 34-235 (392) alignment 
Range on Protein: 966-1209
Range on HMM: 34-235/392.0
QKPDEVTHniASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKqqacy
  |. |..     |. |||  . || |. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. . .|       
iypqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

qywpssgsvvigeyfielenetrnngyiertfeiknsnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtQRKRGNTS--IVVHCSDTVGRSAM
                                      |     .| |...|.|   .  |   ..| ...|.   . . |. .  ...|||  |||...
......................................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgv

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
  .  . . ..|.  ..|||...   | ..|  |||  ||  |   ||  
visidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 967-1127 2.4e-13 44.3 In-house 84-242 (244) alignment 
Range on Protein: 967-1127
Range on HMM: 84-242/244.0
KPDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK-GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKqqacyQYW
 |  .   .  .|  |||    || |  ||||  |     |||| |.        .|... |. .|. .||||. .| |  .|.|   .|       .||
dpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eyw

PSSGSVVIGEYFIELENETRNNG--YIERTFEIKnSNKTAIRLSVVQYQITNWDSTGEVKNPQTI
| |  .   |  | .    |..        .||. |.      ..  .||.|| | |   |   |
pdseplewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdgttpndhfi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 968-1206 1.1e-48 161.2 In-house 14-251 (284) alignment 
Range on Protein: 968-1206
Range on HMM: 14-251/284.0
PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenelkQQACYQY
  . |.    ||||||| .. |. |. .| |.   | |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCA
||  . .  ... ....  .  . |. | .|. .  |     .. |. .  |   |  . |  ......   . |........||||||  |||. .. .
wplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
  . ... | |  .||.....  | |..  || ..||  |   .
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_CG7180_pd Subfamily CG7180 968-1210 1.3e-44 147.1 In-house 31-290 (296) alignment 
Range on Protein: 968-1210
Range on HMM: 31-290/296.0
PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLK---GE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQqACYQY
 ..  ... ..|..|||  . .|.|. || |.   || . ||||||.....  ||..|. | |. .|  .||... |... |.|.|... . ..  . .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPSSGSVVIGEYFIELENETRNNGYIERTFEIKNS------N----KTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRG-----NTSIVV
||  .    || |.|. .|        ||| ..        .    |.  |. | ..|.| |..  .|    . |. . .. |. |..      .  .||
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRi.vklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|..|  | ...| ..
vssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 968-1209 1.1e-18 62.2 In-house 24-269 (285) alignment 
Range on Protein: 968-1209
Range on HMM: 24-269/285.0
PDEVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS
| ..|.     | | || ..    .. || ||    ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   . |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

S-GSVV-IGEYFIELEN--ETRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTilMImeEMYRTQRK--RGNTSIVVHCSDTVGRSAM
  | || .|.| | | .  |    | |  .. . |..  ..  | . . |.  |      .. .   ||  |.|.  .|    .. |.||||  |||.| 
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarp..mi..elykwvkkvnpkekpicvhcsagvgrtat

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
|     .  .   .  |.......  |  .  .||.  |.  .  ... |
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 968-1195 1.2e-12 42.5 In-house 18-206 (255) alignment 
Range on Protein: 968-1195
Range on HMM: 18-206/255.0
PDEVTHNIASQNKDKNRSTQFLppdnyrvplkgehpdyinavfingykekkafiiaespmfnTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS
 |. |.... ... |..... |                                        |  .|...|   . . .||||  .| ... | .|.|  
edvctehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfple

--GSVVIGEYFIELENetRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTILMIMeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAA
  .  .. .  .   .    .  . || ||            |  |. . |      .... || |.    .  |.    |.|||||  .|||| |  | 
kdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlae

TTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQT
           . .| . .|  ..|.  | .......|
lvyqkmirsldttet.veldylslleelrskrkraiht
subfamily_PTPRD_pd Subfamily PTPRD 970-1216 2.6e-66 219.5 In-house 39-287 (564) alignment 
Range on Protein: 970-1216
Range on HMM: 39-287/564.0
EVTHNIASQNKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP
....  ...|| |||  . .. |. || |.     |  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .| ... | .|||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

SSGSVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAAT
..|.  .||. ..||.|.. . |. |||..|....   |  | |.. |.| ..|  ......| ..... ... ....  ||||||  |||. .|..   
ekgtetygeltVtleeeeeladyeirtfklkkkkssesr.eVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivida

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTY
 ... |.|...|..|..|  | |..  ||| .||  | ...| .|....| 
mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_PTPN3_pd Subfamily PTPN3 970-1209 1.9e-42 140.1 In-house 32-274 (280) alignment 
Range on Protein: 970-1209
Range on HMM: 32-274/280.0
EVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP
....   ..| .|||    || |. || || .. ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |  .. |.||||
aisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

SSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
... ..  ||. ...|.| ... |. | . .|.....  | ...| | ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  
etedeleygefsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlille

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
|.. .  ..  . . ....  | |.   |||..||. .|. .|. 
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 970-1050 6.4e-08 26.5 In-house 37-117 (347) alignment 
Range on Protein: 970-1050
Range on HMM: 37-117/347.0
EVTHNIASQNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
....| . . | .. .   | |.. .     .   ||||  |.  . .| .|... |. .| |.||||.   .|| .| . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0040439 (Phosphotyrosine protein) phosphatases II 971-1210 2.7e-58 192.8 In-house 3-246 (249) alignment 
Range on Protein: 971-1210
Range on HMM: 3-246/249.0
VTHNIASQNKDKNRSTQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS
... .   ||||||.. .||.|. || |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... ||... |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

SGSVVIGEYFIELENETRNNGYIERTFEIKNSnKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAAT
.||...|.....| ... ...|. ||.|..|. ..   . | ..|.|.|  .|  ......| ..|..   ...   .. ..||||. |||...|.|| .
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
 ..  ..|. .|.....|  | |.||.||.  ||. .....| .|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 971-1215 9.6e-48 157.8 In-house 40-289 (297) alignment 
Range on Protein: 971-1215
Range on HMM: 40-289/297.0
VTHNIASQNK---DKNRSTQFLPPDNYRVPLKG--EH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQqACYQY
.. .  ...|   .|.| .  || |  || |.   ..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..|| ..  | .|
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPSSGSVVIGEYFIELENETRNNGYIERTFEIKNSNkTAIRLSVVQYQITNWDSTGEVK--NPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFC
|. .|..  |.  ..|.  .. .|.|.|..|..... .  |  | ||| ..| .  . .  . ...| ...|.  .  .. .. ..|||.  ||| ....
WsdkgvttfGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
.    . . | |  .|.|...|  | ..|  |||  ||. . ..|| .| | .|
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 973-1213 1.1e-27 91.5 In-house 48-286 (290) alignment 
Range on Protein: 973-1213
Range on HMM: 48-286/290.0
HNIASQNK--DKNRSTQFLPPDNYRVPLK-GEHPDYINAVFINGYKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS-G
 .|  .|    |||  .    |  || || | . ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||   |  .  | ||.|   |
rkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

S-VVIGEYFIELE-NETRNNGYIERTFEIKNSNKTaIRLSVVQYQITNWDSTGeVKNpqTILMIMEEMYrTQRKRgNTSIVVHCSDTVGRSAMFCAAATT
  . .||. .    ......  | .|. ... ..      .  ..|  |     | .  . | ..  .. . ||  .  .|||||  .||.  | |  ..
evltfGeitvlcseeddkdaniikktlsvrdkdsG.kehklkhlkikswpdks.val..stlallrtlr.ilrka.sGpvvvhcsaGiGrtGtfvaievg

InKCKTEG-VIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSF
. .. ..|  .|. .. .. |  . .|||  .||  . .|.| .  .|
l.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 974-1024 4e-06 20.9 In-house 43-94 (95) alignment 
Range on Protein: 974-1024
Range on HMM: 43-94/95.0
NIASQNKDKNRSTQFLPPDNYRVPLKGE-HPDYINAVFINGYKEKKAFIIAE
  .  |  |||  . .| |  || |      |||||.|..||  |...| |.
gsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
0037934 (Phosphotyrosine protein) phosphatases II 975-1209 1.5e-53 177.2 In-house 6-241 (243) alignment 
Range on Protein: 975-1209
Range on HMM: 6-241/243.0
IASQNKDKNRSTQFLPPDNYRVPLKGehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENELKQQACYQYWPssGSV
.  .|..||| . .|| |. || |.|   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... ||... |.||||  |.|
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev

VIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAA
..|.....| .|.  ..|. ||....| . .   . |..|. ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....||
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

ATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVTQYEGICQIVLAY
 . . ..   | .|.....|  | |.|| .|||  ||. . ...| .
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 975-1211 9e-44 144.6 In-house 40-278 (315) alignment 
Range on Protein: 975-1211
Range on HMM: 40-278/315.0
IASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS--SG
  ..|  |||    || |. || |    .  . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|  .  | ||||   . 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
||  |.. .|| .   . . . | . ...|...     | |.| |.|   |  |.  ..| .. |.    ... . |..||||  |||. .....   ..
svefGsikvellsleadtdgvarklvtrkseesr...tvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

KCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
. | . ..|||...|  | ..|  |||  .|  | ..|| .| 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 975-1211 2.8e-38 126.5 In-house 16-265 (270) alignment 
Range on Protein: 975-1211
Range on HMM: 16-265/270.0
IASQNKDKNRSTQFLPPDNYRVPLKGEHPD----YINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGS
 | ..|  ||... ||  . || |. .. |    |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|  .. | .|||..  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

V--VIGEYFIEL--ENETRNNGYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEVKNP------QTILMIMEEMYRTQRKRGN-TSIVVHCSDTVGRSA
    . . .|.   ..|....||| .  ..... ..     .| .. ..|   | ....      . .| ..... |....  . . ..||||. |||. 
ekvkledgkikvlalseekeegyiltrlrleekgeer...rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
.. |  ....  .... .|| ....  | ...  ||.. ||| . . |. | .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0042113 (Phosphotyrosine protein) phosphatases II 976-1210 2e-59 196.3 In-house 6-243 (245) alignment 
Range on Protein: 976-1210
Range on HMM: 6-243/245.0
ASQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVV
   ||||||....|| |. || |. .      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | ||... |.||||...|..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

IGEYFIELENETRNNGYIERTFEIKNsNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
.|.....| .|. ...|. ||.|..| ...   . |..|. ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  .
ygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
.|. .......|  | |.||.|||  ||. . ...| .|
kelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 976-1207 4.8e-46 152.1 In-house 46-276 (315) alignment 
Range on Protein: 976-1207
Range on HMM: 46-276/315.0
ASQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSgSVV
 ..||.|||  . .. |. || |    . .| ||.|| ||.||. |. .| |..|  .. ..||... . ... ||||    | ... . .|||    |.
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kvi

IGEYFIELENETRNNGYIERTFeiKNSNKTAIRlSVVQYQITNWDsTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 |.. . . .|  |. |  ||.      .  ||  |||...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... .
yGkitvtrkseevnteytvrtl..svvfgdnir.evvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
.| .|||.....  | .. . ||.. ||. | ...|
aenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 977-1218 1.9e-59 195.9 In-house 7-250 (250) alignment 
Range on Protein: 977-1218
Range on HMM: 7-250/250.0
SQNKDKNRSTQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQaCYQYWPSSGSVVI
 |||.||| ..... |. || |. |.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   .| ... . ||||  ..   
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GEYFIELENETRNNGYIERTFEIKNSNKTAIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
|.  ..| ..     |. |.. . . .|.  |  |.|.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.
Gdvtvsllskeefadytkrklklskakkader.ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQTYSN
| |.|||.|.|  |...|..|.. .||  . .|.| .|||.. |..
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_PTPRA_pd Subfamily PTPRA 977-1209 6.2e-58 191.2 In-house 56-294 (330) alignment 
Range on Protein: 977-1209
Range on HMM: 56-294/330.0
SQNKDKNRSTQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVI
 .||.|||  . || |  || |    | |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .| |.. |.||||. |.|  
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty

GEYFIELENETRNNGYIERTFEIKN----SNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTIN
|.  .|.|.||  . |  | | ...    ... . || | |.  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ..
Gnirvevedetvlvdytvrkflvqqlpdatrekksrl.vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

KCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
. |.|...|||...|. | |.|  |||  ||| | ...| |
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRK_pd Subfamily PTPRK 977-1207 1.2e-49 163.9 In-house 41-274 (314) alignment 
Range on Protein: 977-1207
Range on HMM: 41-274/314.0
SQNKDKNRSTQFLPPDNYRVPL---KGE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVvI
 .|..||||.. |..|. || |   .|. . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  |  .  |..|||  ..|  
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.y

GEYFIELENETRNNGYIERTFEIKNSNK-TAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCK
|.  .|| . . .. .. |.| ......    .  | |.| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  .
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmie

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
.|||.|||.. |. | .|.  |.|  ||  | ...|
regvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 977-1211 4.7e-44 145.5 In-house 26-269 (274) alignment 
Range on Protein: 977-1211
Range on HMM: 26-269/274.0
SQNKDKNRSTQFLPPDNYRVPLKGE-----HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSV
. .. ||| .. || .| || |. |       .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .| ..| | .|.| . ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

VIGEYF----IELENETRNNGYIERTFEIKNSNKtaiRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAA
 | | .    |. |. ...|.|  |.. .|....   . ||. |  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |. 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
 .... . |.|.||...    |... | |||  ||| | ...  || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 977-1211 9.5e-43 141.0 In-house 41-277 (515) alignment 
Range on Protein: 977-1211
Range on HMM: 41-277/515.0
SQNKDKNRSTQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS--SGSV
  |  |||    || |. || |       | ||.|| .|....  ||.| .  |   .  .||... . |||.|.|. . .|  .  | .|||   . ||
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

VIGEYFIELENETRNNGYIERTFEIKNSNKtaIRlSVVQYQITNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
  |.. .||       | | |....  ...  .|  | |.. |.|   |  |. ...| .. |. .... . . ....|||  |||  .....   . . 
kfGsikvelvsleactggikrkltvlkgdd..sr.tvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvaha

KTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
||  ..|||....  | ..|  |||  ||  | ..|| .| 
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 977-1209 1.1e-22 75.0 In-house 35-268 (281) alignment 
Range on Protein: 977-1209
Range on HMM: 35-268/281.0
SQNKDKNRSTQFLPPDNYRVPLKG-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVV
  |. ||| ..    |  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | ... | .|.|    ..
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

--IGEYFIELENETRNNGYIERTFEIKNSNKTaiRLsVVQYQITNWDstgEVKNPQTIlMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINK
  . .. .. |. | |.  .   ...    .|  || . ..   .|    . . |..   .| .. |  | |  |  |.|||  ||||  . |   ... 
lqfdklsvsyedstvnkslvttrlnlsyeget..rl.ithwlwkewp...dwqvpess.evmlkilrkirar.stppvihcsagvgrsgtlmaveialqs

CKTEG-VIDVFQVLKSQRIQ-KPGSVQTVTQYEGICQIVLAY
 ..   . |. |..   |.  .  ||||. ||  | ...| .
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 977-1210 8.3e-20 65.6 In-house 53-289 (305) alignment 
Range on Protein: 977-1210
Range on HMM: 53-289/305.0
SQNKDKNRSTQFLPPDNYRVPLKGEHP-DYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS-GSVVIG
  .. ||| ..    |.  | |.   | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  || .  | |||| . |  .  
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

EYFIELENETRNNgYIERTFEIKNSN-----KTAIRLSVVQYQITNWDSTGEvknPQTILMIMEEMYRTqRkRGNTSIVVHCSDTVGRSAMFCAAATTIN
   | .|| . ..  .||  ||. .          ..|| . | |.|   |    |   |  .| .    |   .  ||||||  .||.    |    ..
ksgivvenvsgsk.pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppckltslellsai.r.gskvpivvhcsagigrtgtivaieyile

KCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
|   .  .  . ...|. | |.  |.|.  ||  | ...| |.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 977-1068 4.5e-15 50.3 In-house 31-126 (297) alignment 
Range on Protein: 977-1068
Range on HMM: 31-126/297.0
SQNKDKNRSTQFLPPDNYRVPLKGEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG
.    ||| .. |  |. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|  .. |. ||||. 
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 977-1059 1.7e-07 25.1 In-house 32-118 (332) alignment 
Range on Protein: 977-1059
Range on HMM: 32-118/332.0
SQNKDKNRSTQFLPPDNYRVPLKGE--HPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENEL-KQQA
 .| | ||  ..   |  || |  .  . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |...   .|  |..|
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 978-1211 5.1e-35 115.6 In-house 37-278 (287) alignment 
Range on Protein: 978-1211
Range on HMM: 37-278/287.0
QNKDKNRSTQFLPPDNYRVPL--KGEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG-SVVIG
 .  ||| .. || |. || |  .||.  ||||| .. .|....||| | .|.  | |.||... .......... .| |  .. ||.|||     . .|
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFI-ELENETRNNGYIERTFEIKNSNKTAIRLsVVQYQITNWdsTGEVKNPQ---TILMIMEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATT
 | .  |. . ..  |  |.. . . .    |. | |... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . 
GysvvlldydikePeygvralrlidletrearv.vkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
... .  | .|| .|.   | .. . ||.| |.  ... . .|  
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 978-1207 1.8e-30 100.9 In-house 2-236 (237) alignment 
Range on Protein: 978-1207
Range on HMM: 2-236/237.0
QNKDKNRSTQFLPPDNYRVPLKGE--HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGS-VVIG
.|| |||  .    |  || |||     ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    | ... |..||||.      |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYFIELENETRNNGYIERTFEIKN-SNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK
 . . |  .     |  |.. . .  ..  .|| . |||.| |   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..|
vltvslkkkeefsdytvrslllskrltlkevrl.ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
 . |.|... ..|   ..|  .||  ||  | | .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0049772 (Phosphotyrosine protein) phosphatases II 978-1216 1.9e-26 89.0 In-house 45-286 (314) alignment 
Range on Protein: 978-1216
Range on HMM: 45-286/314.0
QNKDKNRSTQFLPPDnYRVPLKG---EHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM--------------
 |.||||....|| |  || |.|   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCHENELKqqacyqywpssgS-------VVIGeyfielenetrnngyiertfEIKNSNkTAIRLSVVQYQITNWDStGEVKNPQTILMIMEEM
       |.   ..             .         .                     |. ...       ...|  ....  |..  .. .. ..| .
aAlgKtpllildgng............neptaadlellk....................eelydp.elferlgikylripvpD.gsaplledfdeflefi

YRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVTQYEGICQIVLAYLDSFQTY
 .    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |....  ||| | ...| ||. ....
eea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 978-1211 8.6e-22 72.5 In-house 42-272 (288) alignment 
Range on Protein: 978-1211
Range on HMM: 42-272/288.0
QNKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS-GS-VVIGEY
.|  ..| ..    |  || |. .   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |. ...  .|.||  |  . || .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

fIELENETRnnGYIERTFEI---KNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
      . |    |... ..   ..|...  .  | .  . .||  |  .| .. | ..| .     |  .  ||||.|  |||.. .      ..  . 
.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrl

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLD
.  . . ..|.. | ..  ..||  ||  . ..|| .| 
ddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 978-1086 1.2e-11 38.9 In-house 46-169 (350) alignment 
Range on Protein: 978-1086
Range on HMM: 46-169/350.0
QNKDKNRSTQFLPPDNYRVPLK------------GEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQA
.   ||| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  . ||  . 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CYQYWPSSGsvvIGEYFIELENETRNN
||.||.  .   . .. . |..  .| 
cyrYWqegs...ydditvklaskweni
Y_phosphatase Protein-tyrosine phosphatase 979-1207 4.4e-64 211.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 979-1207
Range on HMM: 1-234/235.0
NKDKNRSTQFLPPDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP--SSGSVVIGE
||.|||....|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....| ....| ||||  ...|.  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YFIELE-NET-RNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
...||. .|.  ...|. |..|.|....   . .| |...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
|. .||.|..|. | |.||.||...||. .....|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 979-1207 4.4e-64 211.5 In-house 1-234 (235) alignment 
Range on Protein: 979-1207
Range on HMM: 1-234/235.0
NKDKNRSTQFLPPDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWP--SSGSVVIGE
||.|||....|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....| ....| ||||  ...|.  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YFIELE-NET-RNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
...||. .|.  ...|. |..|.|....   . .| |...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
|. .||.|..|. | |.||.||...||. .....|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 979-1209 9.2e-33 108.7 In-house 1-170 (182) alignment 
Range on Protein: 979-1209
Range on HMM: 1-170/182.0
NKDKNRSTQFLPPDNYRvplkgeHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenelkqqaCYQYWPssgsvvigeyfie
|.|||| . .||.|. |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

lenetrnngyiertfeiknsnkTAIRLSVVQYQITNWDSTGEVKnPQTILMIMEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDV
                      .     ..||. ..|.  |    ....| ..||...      .  ..||||  |||.....||   . .    | ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
....|  | ..||.|.|  ||  . ...| .
eeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 979-1207 2.2e-28 94.0 In-house 7-237 (239) alignment 
Range on Protein: 979-1207
Range on HMM: 7-237/239.0
NKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIg
|| ||| .. .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    | ... |.|||| | |    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

EYFIELENETRNNGYIERTFEIKNSNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
.  . | .      || ||| . .  .|  |  | ||..| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .
nlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVL
  .|.|. .|. | ..|  |||  ||  |   ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 979-1206 2.8e-28 93.7 In-house 8-237 (239) alignment 
Range on Protein: 979-1206
Range on HMM: 8-237/239.0
NKDKNRSTQFLPPDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIg
|| ||| .. .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    | ... |.|||| | |    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

EYFIELENETRNNGYIERTFEIKNSNKTAIRLsVVQYQITNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
.  . | .      || ||| . .  .|  |  | ||..| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .
nlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIV
  .|.|. .|. | ..|  |||  ||  |   |
ktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 979-1216 4.2e-15 50.2 In-house 43-282 (312) alignment 
Range on Protein: 979-1216
Range on HMM: 43-282/312.0
NKDKNRSTQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG-------SVV
 || ||  .    |  |  | |.   || | |..     . |.....|. ||. .||..      |.|..||   |   . | .|              |
fkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

IGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTIN
  ||  |.|   . .  |         . |     . .|| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... 
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalr

KCKTEGVIDVFQVLKSQRIQkpgSVQTVTQYEGICQIVLAYLDSFQTY
. . . | |.| .|. .| .   ||... ||    ..|| .| |   |
hprkqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskgly
subfamily_eak_pd Subfamily eak 986-1121 4.3e-09 30.2 In-house 58-195 (332) alignment 
Range on Protein: 986-1121
Range on HMM: 58-195/332.0
TQFLPPDNYRVPLKG---EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG--SVVIGEYFIELE
 . .| | | | |     ..  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. ||| .   .|.|  .   .  | . .|  
vkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverk

NETRNNGYIERTFEIKNSNKTAirlSVVQYQITNWDSTGEV
.  ..| .  | .|..  |.|     |  |..  |  |   
efvkrniletrllelskGneth...rvlhykvfGwtettlp
0046846 (Phosphotyrosine protein) phosphatases II 995-1211 1.2e-28 95.5 In-house 4-174 (176) alignment 
Range on Protein: 995-1211
Range on HMM: 4-174/176.0
RVPLKGEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSVVIgeyfielenetrnngyiertfe
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. | ||..  |..|||   .. |                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

iknsnktairlsvvQYQITNWDSTGEVKNpQTILMIMEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              ||. ..|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTVTQYEGICQIVLAYLD
||  ||. . . .| .|.
qtpeQyrflyefellllk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 995-1206 2.8e-17 57.8 In-house 34-255 (290) alignment 
Range on Protein: 995-1206
Range on HMM: 34-255/290.0
RVPLKGE----HPDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENELKQQ----ACYQYWPSS--GSVVIGEYFI
||.|||       ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .| ...    || .| | |  ... ..   .
rvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

ELENETRNNGYIERTFEIKNSNKTaiRLSVVQYQITNWDSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVI
.  .   ... ..|. ..|  ..    . |  ... .|...   ....|.| ... .     |  .| ..||| | . |||.. |      |   |.| .
kCkskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

DVFQVLKSQRIQKPGSVQTVTQYEGICQIV
 . .|||. | |.   ... ...  .   .
kledvlkalrkqralaitsalelafvdagi
0043147 (Phosphotyrosine protein) phosphatases II 1001-1203 2e-27 91.4 In-house 3-154 (172) alignment 
Range on Protein: 1001-1203
Range on HMM: 3-154/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnelkqqacyqywpssgsvvigeyfielenetrnngyiertfeikNSNK
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                              ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TAIRLSVVQYQITNWDSTGEVkNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVTQY
.    ...||. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.  ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

EGIC
  ..
rfly
0044763 (Phosphotyrosine protein) phosphatases II 1001-1205 5.6e-22 73.7 In-house 16-166 (178) alignment 
Range on Protein: 1001-1205
Range on HMM: 16-166/178.0
EHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSGSvvigeyfielenetrnngyiertfeiknsnk
|  |||||..| ..     ....  |.     ...... . ..|.||.|..| || .. |..|||.. .                               
ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

tairlsvVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVTQYE
       .||. ....  |.   .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..  |..
.......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

GICQI
 ....
qLyef
0051429 (Phosphotyrosine protein) phosphatases II 1002-1215 3.2e-35 117.5 In-house 3-230 (272) alignment 
Range on Protein: 1002-1215
Range on HMM: 3-230/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENELKQQACYQYWP------------SSGSVVIGEYFIELENETRNN
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.|.... |..|||            |  .. .| ... |  |.  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERTFEIKNSNKTAIRLSVVQYQITNWDSTGEVKNPqtILMIMEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------V
 || |......  ..   . | ... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVTQYEGICQIVLAYLDSFQT
.....  | | ||.||| .||. .....|..|.|...
eeaveelraqrpgavqteeqylflyeallellrslls
0051082 (Phosphotyrosine protein) phosphatases II 1002-1202 3e-22 74.3 In-house 2-145 (151) alignment 
Range on Protein: 1002-1202
Range on HMM: 2-145/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENELKqqACYQYWPSSGsvvigeyfielenetrnngyiertfeiknsnkt
..||||. .. |.     ...   |       |.... . ....||.|. | | .   |..|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

airLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVTQYEG
   . |....|..|. .|   .....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. .|.  
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

I
.
q
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1002-1123 5.2e-10 33.7 In-house 12-129 (130) alignment 
Range on Protein: 1002-1123
Range on HMM: 12-129/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKqqacyQYWPSSGSVVIGEYFIELENETRNN-GYIERTFEIKNSNK
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|       .||| |  .   |  | .    |..  .|. ..   .|. 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnleiesdl

TAIRLSVVQYQITNWDSTGEVKN
     ..  .||.|| | |   |
neshqaltmfqisnwpsdgttpn
0036282 (Phosphotyrosine protein) phosphatases II 1004-1204 1.1e-33 111.7 In-house 3-164 (174) alignment 
Range on Protein: 1004-1204
Range on HMM: 3-164/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSsgsvvigeyfielenetrnngyiertfeiknsNKTAI
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.||.   |..|||.                                ...  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

RLSVVQYQITNWDSTGEVKNPQtILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVTQYEGIC
. ...||. ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||  ||. . 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
0049260 (Phosphotyrosine protein) phosphatases II 1010-1203 5.3e-26 86.5 In-house 1-143 (152) alignment 
Range on Protein: 1010-1203
Range on HMM: 1-143/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWpssgsvvigeyfielenetrnngyiertfeiknsnktairlsvvQ
||.||. ...||... |. ||. .||.|. . ..|.||||. . ||.   |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YQITNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVTQYEGIC
|. ..|.  |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..  |.. . 
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1011-1098 1.8e-10 34.7 In-house 229-314 (440) alignment 
Range on Protein: 1011-1098
Range on HMM: 229-314/440.0
INGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcheNELKQQACYQYWPSS-GSVVIGEYFIELENETRNNGYIERTFEIKNS
..||  |.||| .. |.  |  .||... | ....|.||   |.|....|  |||    || .| . .        |    ||.|.|  
fegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1015-1204 6.1e-14 46.6 In-house 2-198 (199) alignment 
Range on Protein: 1015-1204
Range on HMM: 2-198/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFeIKNSNKTAI--RLSVVQY
| .. .| .. |. .|  .||.|. .     |||.  ..  |.     |||..  |.   |   .  .  | .  |   .. |  .| ||      . .|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishy

QITNWD--STGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQ
|.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . .. .|. | |
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1016-1204 8e-14 46.3 In-house 2-197 (198) alignment 
Range on Protein: 1016-1204
Range on HMM: 2-197/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRNNGYIERTFeIKNSNKTAI--RLSVVQYQ
 .. .| .. |. .|  .||.|. .     |||.  ..  |.     |||..  |.   |   .  .  | .  |   .. |  .| ||      . .||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyq

ITNWD--STGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQ
.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . .. .|. | |
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1017-1210 8.6e-10 31.7 In-house 114-309 (346) alignment 
Range on Protein: 1017-1210
Range on HMM: 114-309/346.0
KKAFIIAESPMFN---TARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSSG-SVVIGEYFIELENETRNNGYIERTFEIKNSNKTAIRLSVVQYQi
.. .|.|. | ..      .|| || . ..  . ..  .. ||. .   .    |     |  ||.           | | |.    ..   .  |... 
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhh.

TNWDSTGEvkNPQTILMI-MEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
. |    .   |.|. .| |   . ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|.. .|| .|  ||. |.
apwkhlqq..ppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_hpo-7_pd Subfamily hpo-7 1022-1195 5.7e-13 43.4 In-house 42-212 (263) alignment 
Range on Protein: 1022-1195
Range on HMM: 42-212/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPSS--GSVVIGEYFIELENETRnnGYIERTFEIKN--SNKTAIRlSVVQYQITNWDS
.    . .|  .|...|   . . .||||  ||  .. | .|.|    .  .. .  .   .       . .| |. .  ..|  ..  | .|. . |  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkth.tvkhysykgWie

TGEVKNPQTILMIMEemyrTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQT
. ...... || |..        |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......|
kndpelareilnilk....va..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraiht
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1023-1199 5.3e-15 49.7 In-house 96-277 (302) alignment 
Range on Protein: 1023-1199
Range on HMM: 96-277/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCHENELKQQACYQYWPS--SGSVVIGEYFI-------ELENETRNNGYIERTFEIKNSNKT-AIRLSVVQYQI
   |  .|   .| .|.. ||. .| ||.  | ... | .|.     | .  |.| .       .||. |  ...   | ||||..|. . . .|   . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGEVKNPQTILMIMEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQY
. |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||. .| 
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
0048179 (Phosphotyrosine protein) phosphatases II 1037-1203 6.3e-13 44.2 In-house 24-138 (144) alignment 
Range on Protein: 1037-1203
Range on HMM: 24-138/144.0
MIDDRNVTAIVMLCHENELKQQACYqywpssgsvvigeyfielenetrnngyiertfeiknsnktairlsVVQYQITNWDSTGEVKNPQTILMIMEEMYR
.. . ..|... |..| |     ..                                             ..||. ..|.  |    .. .| ..| . .
llkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefiee

TQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVTQYEGIC
 ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..  |.. ..
ale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 1088-1207 3.4e-13 45.0 In-house 29-140 (145) alignment 
Range on Protein: 1088-1207
Range on HMM: 29-140/145.0
YIERTFEIkNSNKTAIRLSVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRI
 | . . .  |...     ..||. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | 
gittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrs

QKPGSVQTVTQYEGICQIVL
| ||.|... |.. ... .|
qrpgavpnpgqlrflyefel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1104-1167 1.8e-06 21.9 In-house 214-286 (350) alignment 
Range on Protein: 1104-1167
Range on HMM: 214-286/350.0
RLSVVQYQITNWDSTGEVKNPQTILMIME--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATTI
 . | | |. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....    .
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1106-1210 6.8e-13 42.7 In-house 90-194 (440) alignment 
Range on Protein: 1106-1210
Range on HMM: 90-194/440.0
SVVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQI
.. ||.   |   |  |    .| .....  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||  ||  . . 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

VLAYL
||  |
vlegl
PTPc_DSPc_SM00012 1107-1207 3.3e-21 70.8 In-house 2-104 (105) alignment 
Range on Protein: 1107-1207
Range on HMM: 2-104/105.0
VVQYQITNWDSTGEVKNPQTILMIMEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQ
| .|..|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| .||  ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IVL
..|
all
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1129-1210 4.6e-09 30.5 In-house 215-295 (297) alignment 
Range on Protein: 1129-1210
Range on HMM: 215-295/297.0
MIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAYL
..  | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||. |.| . ..||. |
flqleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 1139-1209 1.2e-07 25.7 In-house 243-314 (319) alignment 
Range on Protein: 1139-1209
Range on HMM: 243-314/319.0
RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVTQYEGICQIVLAY
..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|. ||| | ...  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey