Gene PTPRD-19 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP072_AA protein Get Run
AqueP072_AA_1013-1260 phosphatase_domain Get Run
AqueP072_AA_1262-1360 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 284-355 7.1e-06 19.3 Pfam-A 2-77 (85) alignment 
Range on Protein: 284-355
Range on HMM: 2-77/85.0
TPTGLTATRLstGLAHVRLSWSTV----SGATGYEVYYQLS-SNT-PVSISNTSYATINVTSGLIQGSTYTFYVVSYG
 |..|...    .   ..||||      .  ||||| |. . ..  ........ .|  . .||  |..|.| | .. 
aPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn
fn3 Fibronectin type III domain 470-553 1.7e-13 43.7 Pfam-A 2-83 (85) alignment 
Range on Protein: 470-553
Range on HMM: 2-83/85.0
PVDDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
.. .. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 578-647 6.4e-14 45.0 Pfam-A 13-84 (85) alignment 
Range on Protein: 578-647
Range on HMM: 13-84/85.0
PTEIVIIWNPPTIPNGIITVYEIRYRKSTSTG---SYNITNTTNtYYSIVGLIPNTSYTIGVRAYTSIGPGEW
.|.... |.||. ..| || ||..||......   ......||.  . . || |.|.|.. |.|..  | |..
stsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpe
TMEM154 TMEM154 protein family 778-860 3.6e-07 21.6 Pfam-A 17-98 (146) alignment 
Range on Protein: 778-860
Range on HMM: 17-98/146.0
RQTSTVMQTSTAIVTSSTPVTTSTASSNPPESSAGGSSGGAiAAGIIIPLLLVIGLVIVIIVVVVVWRKKKGKDEVVYYNTRT
..  || ....| ||.. ... .. ...   | .  ..       ||||... | |..|....|.. ..|. |.|    ... 
lekatvtastlasvtdpetlsanvnleegelseksadqael.vlmiiiPsvvLillllvvvilvikkkrkrrKqeetsedeke
Ig_3 Immunoglobulin domain 901-975 3.9e-06 19.0 Pfam-A 1-75 (75) alignment 
Range on Protein: 901-975
Range on HMM: 1-75/75.0
PPVIEEFPSNMTTEEGReVLFKVKVKETS-KPSFNWYhNGEPVTDDYAHELRGDGSLLLLS-VEEKHKGTYRFVANN
.|||   ||...|..|  | .   .. .. .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
I-set Immunoglobulin I-set domain 902-988 1.2e-15 49.0 Pfam-A 1-90 (90) alignment 
Range on Protein: 902-988
Range on HMM: 1-90/90.0
PVIEEFPSNMTTEEGREVLFKVKVKETSKPSFNWYHNGEPVTDDYAHELRGDG---SLLLLSVEEKHKGTYRFVANNDAGTVSQQVVLTV
|.... .......|| .| ....|... .||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
Ig_2 Immunoglobulin domain 903-988 4.7e-06 18.5 Pfam-A 3-80 (80) alignment 
Range on Protein: 903-988
Range on HMM: 3-80/80.0
VIEEFPSNmtTEEGREVLFKVKVKETSKPSFNWYHNGEPVTDDYAHelrgdgsLLLLSVEEKHKGTYRFVANND-AGTVSQQVVLTV
|... |..   .||  | .  ...   .|.. ||..||...   .        |.. .|.....|||. .| |.  ...|. | .||
vlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
0050432 (Phosphotyrosine protein) phosphatases II 1000-1260 7.4e-80 263.9 In-house 15-268 (308) alignment 
Range on Protein: 1000-1260
Range on HMM: 15-268/308.0
HGDSSSAKIGMIPVDKFGEFVANghAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLnqipgnrDCQNDYVNACYIDGY--S
...| ...   ..|... ... .  |... ... .| .|.|  . .. ..|  . ||..||. .|. || .|. |       |  .||.|| |.|||   
rdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssk

QDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPES---GSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHF
.. |.||||||  .|. ||||..|... .||||.|.  | ...||.||||..   ||. ||.|...|.. . |.|||.|...|| ||...  . .|..|.
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhy

TSWPDHGVPEYATSILQFHRRIKNEYkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
|.|||||||......|.| ..... .   .||..||||||||||||| |.|. |.| |||||.|. 
tnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvf
subfamily_PTPRA_pd Subfamily PTPRA 1004-1260 7.7e-77 253.4 In-house 7-264 (330) alignment 
Range on Protein: 1004-1260
Range on HMM: 7-264/330.0
SSAKIGMIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcqNDYVNACYIDGYSQDYKYI
.. |   .||.|. | .    |  |. || .| .| .|. . .. .|  . ||  ||. ||. || .|. |... |. .   ||.|| .|||| .  |.|
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykekdkfi

ATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSD---QPPLLITQYHFTSWPDH
|.||| ..|. ||||.||. |   |||.|..|| |. ||.||||. |. .||  |.|. ... | |||.|.. .. |.     ... |..|.||||||| 
aaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv

GVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
|||  .  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|. 
GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvf
0039614 (Phosphotyrosine protein) phosphatases II 1009-1259 8.9e-74 243.9 In-house 12-257 (297) alignment 
Range on Protein: 1009-1259
Range on HMM: 12-257/297.0
GMIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEhsVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrDCQNDYVNACYIDGYSQ-DYKYIATQG
 .||.. .  ..   .|... ... .| .| |   .   .||  . ||..||. .|. ||..|. |. ..|  |  .||.|| |.|||.. . |.|||||
ipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqg

PVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKiKCHQYWPESGStSYGPFRIELTKDQALSDYTIREMHLTLlgsDQPPLLITQYHFTSWPDHGVPEYAT
| ..|. ||||..|... .||||.|. .| .. ||.|||||.|.  ||.|...|.| . |..||.|....|    ..... .|....|.|||||||....
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppsle

SILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDI
..|.| . ... ..  | .||.|||||||||||||| |... |.| |||||.|.
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1009-1261 7.5e-52 171.4 In-house 3-258 (325) alignment 
Range on Protein: 1009-1261
Range on HMM: 3-258/325.0
GMIPVDKFGEFVANGHAKGNEGFRSQFGTLNSgENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQDYKYIATQGP
| | | .. |.| . .|. ..||  .|| | | ..  . ..|.   ||  ||| |.| .| .|. |.    . | . ||.|| |.  . .   ..|.| |
gsiavvnlvehvekkkaqdqdgfahefgllps.ddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaP

VTKTLVDFWRLI--WQekPPVIvMVTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTKDQALSDYTIREMHLTLLgSDQPPLLITQYHFTSWPDHGVPE
 |.|. |.|||.  |.   .|. .|.|. ...| .| .|||.    |  .|.....|   . .|||  | ...    ..   . . |... ||.| ||..
ltatindlWrlvldWr..csvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqk

YATSILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
. .... . . .|.     .    . .|.||||||||||||.|...   |..  .|  .|| .
rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1010-1261 2.4e-118 389.2 In-house 1-253 (290) alignment 
Range on Protein: 1010-1261
Range on HMM: 1-253/290.0
MIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDCQNDYVNACYIDGYSQDYKYIATQGPV
.||||||||||||||||||||||.||..|.|||.||.||...|.|||.||||||||||||||| |..|.|..||.|.|.|||||.||.....||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

TKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHG-VPEYATS
..||||||.|||||| ..|||.||..||.| ||.||||.|....||.|.|.|.....|..|..|.....   |....  .|||..|.|...| |....|.
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
.|......|...|.......||||..|||...|.|..........||.||...
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1010-1261 1.3e-112 370.5 In-house 1-248 (287) alignment 
Range on Protein: 1010-1261
Range on HMM: 1-248/287.0
MIPVDKFGEFVANGHAKGNEGFRSQFGTLNS-GENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNqipgnrDCQNDYVNACYIDGYSQDYKYIATQGP
.|||.|||||||.|||||||||. || .|.. ...|..||......||..||...|.|.|..|.||.      ....||.||..||||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHG-VPEYAT
...|...||.||.......|||... ||... .|.|||||. |...|...|||....  ..|..|.....  ....... ..||..|.|...| |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
..|......|...|.......||||..|||...|.|..........||.||...
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfq
0051299 (Phosphotyrosine protein) phosphatases II 1010-1260 2.5e-82 271.9 In-house 4-255 (288) alignment 
Range on Protein: 1010-1260
Range on HMM: 4-255/288.0
MIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQDYKYIATQGPV
 |.|... ..| . .|.|. |.. .| .| |    .....|. . |.. ||. .|. ||..|. |. ..|  .  .||.|| ||||| .. |.|||||| 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

TKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLG---SDQPPLLITQYHFTSWPDHGVPEYA
 .|. ||||..|... .||||.|.. | ...||.||||..||. ||.....|.. . |.|||.|....| |.    |. .. .|..|.|.|||||||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
...|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. 
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvl
subfamily_PTPRB_pd Subfamily PTPRB 1010-1260 1.9e-77 255.2 In-house 6-254 (293) alignment 
Range on Protein: 1010-1260
Range on HMM: 6-254/293.0
MIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQDYKYIATQGPV
 | ..|| |.|.. .|. . .|  .. .|.. .....|..| .. |.  ||. ||. || .|. |...  . . ..||.|| ||.||..  ..||||||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgynsprefiatqGPl

TKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPES-GSTSYGPFRIELTKDQALSDYTIREMHLTLlgsDQPPLLITQYHFTSWPDHGVPEYATS
 .|. ||||..|..|  .|||.|.. |. |.||..|||.   .. ||  ...|.... |.|..|||....    ..    ..|||||||||||||| ...
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektkt

ILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||.
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdif
0045450 (Phosphotyrosine protein) phosphatases II 1010-1259 2e-73 243.1 In-house 8-272 (307) alignment 
Range on Protein: 1010-1259
Range on HMM: 8-272/307.0
MIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGEN--EHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrDCQNDYVNACYI--------DGYSQD
.|.. |.  .|.  ......|.. .| .|.| .    .. .||  . ||..||. .|. ||..|. |. ..|. .  .||.|| |.        ||| ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGST-SYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWP
 |.||||||  .|. ||||..|...  ||||.|. .| ...||.||||..|..  ||.|...|.. . |..||.| ...| |. ..... .|..|.|.||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDI
|||||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||    .|.
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdl
subfamily_Ptp69D_pd Subfamily Ptp69D 1010-1261 6e-67 220.9 In-house 3-256 (307) alignment 
Range on Protein: 1010-1261
Range on HMM: 3-256/307.0
MIPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcqNDYVNACYIDGYSQDYKYIATQGPV
 |..|.  | . . . . ..|.   . .|.. | ..| ...  . |.  ||. .|. .|..|. |..|.|. |   ||.|| .| || .  |.|| |.||
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingked..sdYinasfikgykekkkfiaaqdPv

TKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQ----PPLLITQYHFTSWPDHGVPEY
  |. ||||.|.. .  .|||..|..| .. ||..|||.   . ||   ..| . .  |||.|||....  . .         ..|||.|.|.|  ||| 
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

ATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
|...|.. ..... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||..
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife
subfamily_PTPRD_pd Subfamily PTPRD 1011-1261 3.8e-95 314.6 In-house 5-251 (564) alignment 
Range on Protein: 1011-1261
Range on HMM: 5-251/564.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGeNEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrdCQNDYVNACYIDGYSQDYKYIATQGPVT
|||... |.||. .|...  | ... ....| ...... |  . ||. ||.|||| || .|. |....|.   . ||.|| .|||| .. .|||||||. 
ipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLtLLGSDQPPLLITQYHFTSWPDHGVPEYATSIL
.|. ||||..|...  .|||.|...|..| |||.||||.|...|| . ..|.. . |.||.||.. |    ...    ..|.||||||||||||.|||.|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslL

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
.. |....  .|..||..|||||||||||||..||. |.....|. .|| .
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1011-1260 2e-84 278.4 In-house 4-252 (305) alignment 
Range on Protein: 1011-1260
Range on HMM: 4-252/305.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGenEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVT
| .|.. ... . ... ..|.  |. .| .   |.|. .  .. ||  ||...|...||.|| |.. . .   ..||.||.|.|||..  |||..|||. 
ialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGST--SYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATS
.|..||||||..||. .|||.|...|..| ||.|||||| .    .|.| .||.  .. |||..|.....   .|.    ..||..|.|||||||..|||
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

ILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|. 
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvf
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1011-1261 3.2e-80 264.6 In-house 2-250 (318) alignment 
Range on Protein: 1011-1261
Range on HMM: 2-250/318.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVT
|.|... . |.. ...|.  . ...  |.  |.. . . .... ||  ||.|||. ||. |..|... |.   . ||.|| ||||| .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSIL
.|. ||||..|. .  ||||.|...|. |.|.|.|||..||.|||  ..||...  ||||..||...|  ....    . |||.|||||.|||| ..|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeees.rqvrqyhytsWpdegvpesgasll

QFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
.. |....   |...||..|||||||||||.|.|.|. |.....|. .|. .
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1011-1260 5.2e-77 254.0 In-house 5-252 (319) alignment 
Range on Protein: 1011-1260
Range on HMM: 5-252/319.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEhSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcqNDYVNACYIDGYSQDYKYIATQGPVT
|.|... | . . ...|. ... .| .|. ..|. ... | .. ||. ||. ||. ||  |. | ...|  .   ||.|| .|||| .  |.||||.|. 
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqerekfiatqaPle

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSIL
.|. ||||..|.|.  ..||.|...|. |.|...||||   ..|| . ..| ... |.|| ||...|  . |.     ......|.||||.|||.|||.|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. 
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf
subfamily_PTPRG_pd Subfamily PTPRG 1011-1260 2.3e-74 245.6 In-house 1-256 (563) alignment 
Range on Protein: 1011-1260
Range on HMM: 1-256/563.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENEH--SVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDCQnDYVNACYIDGYSQDYKYIATQGP
.||..| . ||. ||.|. ||  .|  |.|  ...   .. .  ..||  ||  ||| ||  |. |...||. .   ||.|| ||||| .  ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTL---LGSD--QPPLLITQYHFTSWPDHGVP
...|. ||||.||...  .|||.||..|... ||..|||. .|  || ... |.. . |. ||.|.. .        .  .  .|..|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
|...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ... 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvf
0043336 (Phosphotyrosine protein) phosphatases II 1011-1260 2.5e-74 245.5 In-house 2-246 (278) alignment 
Range on Protein: 1011-1260
Range on HMM: 2-246/278.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGENeHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcqNDYVNACYIDGYSQDYKYIATQGPVT
|.| .. ..... ..... ... .| .|.|     . .||  . ||..||. .|. || .|. |. ..|  |  .||.|| |.|||..  |.|||||| .
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlp

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPeSGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSIL
.|. ||||..|... ..|||.|. .| ...||.|||| .||. ||.|...|.| . |.|||.| ...| ||.... . .|.||...||||||||  ...|
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslslll

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.| ..... ... .||.||||||||||||||.|... |.|.|||||.|. 
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1011-1262 6.5e-64 210.8 In-house 6-250 (315) alignment 
Range on Protein: 1011-1262
Range on HMM: 6-250/315.0
IPVDKFGEFVANGHAKGNEGFRSQFGTLNSGeNEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQDYKYIATQGPVT
||.|..  .||. .|  ..||. .. ..  | . | . .|    ||  ||. ||. ||  |. |  .  . | . ||||| .||||..  .|||.||| .
ipldqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpll..endphsdyvnanfidGynkkrryiaaqgpnv

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESgSTSYGPFRIELTKDQALSDYTIREMHLTlLGSDqpPLLITQYHFTSWPDHGVPEYATSIL
 .. |||||...|.   |||.||. |..| |. .|||.     ||.. . . ...  ..||.| .  .  |..     . |.|.||||| |||.|.....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv.fgdn..irevvqlhytswpdmgvpkytiplm

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIINN
...|..|   . . |...|||||||||||||...|  |.||| |  ||. | 
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1011-1261 6.9e-62 204.1 In-house 3-247 (315) alignment 
Range on Protein: 1011-1261
Range on HMM: 3-247/315.0
IPVDKFGEFVANGhaKGNEGFRSQFGTLNsGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQDYKYIATQGPVT
||| .|  || .   .    |  .|  |  . . .  ..| .. | . ||. ||. .| .|. |. |  . . ..||.|| || .. .|  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlp.dPdiyrqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlk

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPE--SGSTSYGPFRIELTKDQALSDYTIREMhLTLLGSDQppLLITQYHFTSWPDHGVPEYATS
 .. ||||...|||.  |||||. .|. |||| ||||.  . |. .| ...|| . .| .| ..|..  |  . ..    .||..|| |||.||.. ..|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees..rtvtqfqftewPdkGvdkqtss

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|. |
llklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1011-1260 2.6e-52 172.8 In-house 10-253 (297) alignment 
Range on Protein: 1011-1260
Range on HMM: 10-253/297.0
IPVDKFGEFVANGHAkgNEGFRSQFGTLnSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQdyKYIATQGPVT
||. .|  .| ...    . |. .|  |    | .. | |  . | . .|..||. || .|. |. .  | | . ||||| .. |. .  ..|.|| |  
iplsdfatlvqknrh..tdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaiv..nddpdsDyvnasfvkgnkh..rlittqmPmk

KTLVDFWRLIWQEKPPVIVMVTNVKEEKKiKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLlGSDQPPLLITQYHFTSWPDHGVPE--YATS
 |. |||.....|.. .|||... .|..| || .||...|.|..|   ..|.  .  . .  ||...|  |. .   .. ||.|..|||. |..   |.|
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsass

ILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .|| 
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdif
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1011-1261 3.7e-44 145.7 In-house 4-206 (392) alignment 
Range on Protein: 1011-1261
Range on HMM: 4-206/392.0
IPVDKFGEFVANGHAkgNEGFRSQFGTLNsGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrdCQNDYVNACYIDGYSQDYKYIATQGPVT
||| .|  || . .   .  | ..|  |  | . .  |.| .. |.. ||. ||. || .|. |. |      ..||.|| ||... ..  |||.||| .
ipvaqfpafveknrh..salffeefhdlp.gpdiypqtvaqkeinlkknryknilpydsarvkleviddi..pdsdylnasyipsfdnekayiasqgpna

KTLVDFWRLIWQEKPPVIVMVTNVKEEKkikchqywpesgstsygpfrieltkdqalsdytiremhltllgSDQPPLLITQYHFTSWPDHGVPEYATSIL
 .| ||||...||..  |.|||..||                                               .    ..|.||| |||..||....|.|
aslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssll

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
.| . .| ..     |...||||||||||  ..||  . .|.|   .|..|
kfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfn
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1012-1107 5.6e-13 42.9 In-house 6-95 (95) alignment 
Range on Protein: 1012-1107
Range on HMM: 6-95/95.0
PVDKFGEFVANGHAKGNEGFRSQFGTLNSGeNEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQipgNRDcqNDYVNACYIDGYSQDYKYIATQG
 |  |   | . |.. .. |  .| ...      . |.  ...| | ||| ||. ||  |. |     .||   ||.|||..|||..   |||.||
hvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvltt...krd..sdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1013-1095 4.9e-07 23.4 In-house 8-85 (440) alignment 
Range on Protein: 1013-1095
Range on HMM: 8-85/440.0
VDKFGEFVANGhaKGNEGFRSQFGTLNSGENEHSvTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcqNDYVNACYIDG
|  | ..| |   .    |  ..  | ||  . |  ||   .||  ||. ||..|| .|..|... |  |  .||.|| ||.|
vadfadyvqnn..rrsrafedewsllpsglsqps.diaslpnnkvknryrnilaydhsrvmleevkgvpd..sdyinasying
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1014-1259 6.8e-50 164.8 In-house 5-247 (439) alignment 
Range on Protein: 1014-1259
Range on HMM: 5-247/439.0
DKFGEFVANGHAKGNEGFRSQFGTLNSGENE--HSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVTK
|.| | | . . . .| |.  | ..|| . .     ..|  . ... ||. ... .|  |. |..|||    .  |.|| ||.|| .|  |||||||  .
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp..hshyinanyikGyyddklyiatqgpkke

TLVDFWRLIWQEKPPVIVMVTNVKEEKKikchqYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTL-LGSDQPPLLITQYHFTSWPDHGVPEYATSIL
|  |||||....|   |||.||. |  |     ||| .. . ||   .   ..  | .|.|| ...     . .    . |.|...|||. ||  |. .|
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

QFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDI
.| | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdi
0040438 (Phosphotyrosine protein) phosphatases II 1015-1260 2.5e-77 255.6 In-house 4-245 (317) alignment 
Range on Protein: 1015-1260
Range on HMM: 4-245/317.0
KFGEFVANGHAKGNEGFRSQFGTLNSGENEhSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLV
.. ...   ..... .....| .| |   . . ..|  . ||..||. .|. ||..|. |. ..|  |  .||.|| |.||...  |.||||||  .|. 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLgSDQPPLLITQYHFTSWPDHGVPEYATSILQFHR
||||..|...  ||||.|. .| ...||.||||. ... ||.|...|.. . |...|.|..... |  |.... .|..|.|.|||||||.. ...|.| .
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

RIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.... ... .||.|||||||||||||| |... |.| |||||.|. 
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdve
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1016-1258 1e-30 101.4 In-house 14-257 (310) alignment 
Range on Protein: 1016-1258
Range on HMM: 14-257/310.0
FGEFVANGHAKGNEGFRSQFGTLNSgENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNqIpgNRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVD
. .|.      | ||.  |.  |.. ... |.|    . .   ||....|. |. |. |. |  ..   .||. | |.        .| .|||. .|..|
lenfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk.i..dksryedyihanyvktnylrstficsqgplqhtiid

FWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGST-SYGPFRIELTKDqALSDYTIREMHLTLLGS-----DQPP----LLITQYHFTSWPDHGVPEY
|||.|.||.   |... .| || . ||  |||  | | .||  |.    . .  .. | .. .|..       .||     | ..  ..  ||| |||. 
fwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde

ATSILqfHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID
    .   .|.  . .  .|| .||||||..|... .|... ......   .|
kchtv..pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1018-1261 2.2e-72 238.9 In-house 16-260 (298) alignment 
Range on Protein: 1018-1261
Range on HMM: 16-260/298.0
EFVANGHAKGNEGFRSQFGTLNSGEN---EHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDCqnDYVNACYIDGYSQDYKYIATQGPVTKTLV
...|  ..|.  |. ..| .|||...   |.. ..| ...||  ||.|.|. .|  |..|... .. ..  ||.|| ....|..   .||||.|.|.|..
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetve

DFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDqPPLLITQYHFTSWPDHGVPEYATSILQFHR
||||....|.  .|||.||..| .|.|.|.|||..|.. || ....| ...  .|...|.....   ..     . | |||||||.||||.|||.|.. |
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllr

RIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
...  ..   |  |..|.|||||||.|||.|||  |....||  .|. .
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1018-1261 1.8e-71 235.5 In-house 10-249 (288) alignment 
Range on Protein: 1018-1261
Range on HMM: 10-249/288.0
EFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFW
. ||. .|....|| ... .| . |...|||..    |.. ||. ||. || .|. |.. . ..  ..||.|| ||||. .. ||||||||...|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfW

RLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGS-TSYGPFRIELTKDQALSDYTIREMHLTllgSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRI
.|....|   |||.|.. |. | ||..|||...  . || . ..|.... | |.. |.. |     ..  | ||||....|||||||| .. .|.. | .
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqv

KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
|.  .   ||..|||||||||||||.|.|. ... |.|  ||...
kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag
subfamily_PTPN9_pd Subfamily PTPN9 1018-1261 7.9e-60 197.4 In-house 5-260 (297) alignment 
Range on Protein: 1018-1261
Range on HMM: 5-260/297.0
EFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFW
|.||  ..||..| . ..  . . . |  .. . ...|   ||..... ||. |. |.....  | . ||.|| ..||| |   .||||||. ||  |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvde..deasdyinanfvdGykqkkafiatqGplkktvsdfW

RLIWQEKPPVIVMVTNVKEEKKIKCHQYWP--ESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRR
|..|...  ||||.| | |....|| ||||  |  |...| ....  ...  .||..| ....    ..    .| . |.||||.|||. |.|.|.. . 
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlek

IKN-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
...             ...|.. |..||||||.||||||...|. |.. |..| .|...
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvve
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1018-1250 1.4e-31 104.4 In-house 11-245 (305) alignment 
Range on Protein: 1018-1250
Range on HMM: 11-245/305.0
EFVANGHAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQipgnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFW
.|| .   || .|.|..| ...  .. . .       ..  ||. ..   |.||. |.          .|. | |.   ..  ..| || |. ||  |||
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkleg.....pwpheyihanyvstptnpkrfictqaplektcadfw

RLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTS--Y--GP----FRIELTKDQ---ALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYA
 . .|.|   | |. |..|    ||..|..        .  .      ..| ..     . .. ...|  |.. |. .  . .|.||.  ||| |||   
ymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaad

TSILQFHRriknEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
..||..      . .|.|||. ||||||.||||. . ..  |.|
lailelle....karpskgpivvhcsagigrtgsvvmleyildq
subfamily_PTPN6_pd Subfamily PTPN6 1019-1255 2.3e-66 218.9 In-house 16-258 (306) alignment 
Range on Protein: 1019-1255
Range on HMM: 16-258/306.0
FVANGHAKGNEGFRSQFGTLNSGENEH--SVTIAVTQSNKPLNRFANIVVYDDNRILLNqipGNRDCQNDYVNACYIDGYS--QDYKYIATQGPVTKTLV
.  ... ....||  .| .|.  |...  | . .  ..||  ||. ||. .|..|. |.    .   ..||.|| ||.. .  .| .|||||| ...|. 
lekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvs

DFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGS-TSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFH
||||..|||.  ||||.|.  |  | || .|||.. . ..||  ... .....|.||..||....   ...    . ||||.||||||||.    .|.| 
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

RRIKNEYKPTK----GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG
. ...... ..    ||..||||||.||||||. ||. |.. ||.|
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkg
0047943 (Phosphotyrosine protein) phosphatases II 1024-1260 2.7e-75 248.6 In-house 7-241 (273) alignment 
Range on Protein: 1024-1260
Range on HMM: 7-241/273.0
HAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLnqipgnRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQE
...|. ... .| .| |  .... ..|. . || .||. .|. ||..|. |       |  .||.|| |.||| .  |.||||||  .|. ||||..|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KPPVIVMVTNVKEEKKIKCHQYWPESG---STSYGPFRIELTKDQALSDYTIREMHLTLLGSDQpPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
. .||||.|.. | ...||.||||..|   |. ||.|...|.. .  .|||.|.. || ||... .. .|..|.|.|||||||.. .|.|.| . ... .
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

KP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.    .||..||||||||||||| |.|. |.| |||||.|. 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1024-1254 7.8e-71 233.4 In-house 10-238 (281) alignment 
Range on Protein: 1024-1254
Range on HMM: 10-238/281.0
HAKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQE
... |.|| ... .|.. ..... | . .. |.  ||. ||| ||  |. ...   |   ..||.|| ...||... .|||||||| ..||.||...|..
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

KPPVIVMVTNVKEEKKIKCHQYWPESG-STSYGPFRIELTKDQALSDYTIREMHLtlLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYK
|  .|||||.  |. |.|||.|||.   ...|| .... |. .. . |  |...|    .. ..  ..| ..|.|||||||. .. .|.|.. ..  . |
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE
 || |...|||||||||||..|.|  ....|.|
ktkaplvihCsaGvGrtGtyialDrlvkaveae
0036941 (Phosphotyrosine protein) phosphatases II 1025-1260 2.7e-76 252.0 In-house 9-246 (297) alignment 
Range on Protein: 1025-1260
Range on HMM: 9-246/297.0
AKGNEGFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLnqipgnRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEK
.... .....| .| .  .  | ..|  . |...||. .|. ||..|. |       |  .||.||.|.|||....|.||||||  .|. ||||..|...
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

PPVIVMVTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTKDQA--LSDYTIREMHLTLLGSDqPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
 .||||.|.. |  ..||.||||.   .|  ||.|...|.. .   |.|||.|....| .|.. ... .|..|.|.||||||||...|.|.| ..... .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvl

K--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGIDII
|  | .||.||||||||||.||| |.|. ||| |   ||||.|| 
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1025-1260 8e-60 197.1 In-house 5-235 (283) alignment 
Range on Protein: 1025-1260
Range on HMM: 5-235/283.0
AKGNEGFRSQFGTLNSGEneHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrdcqnDYVNACYID---GYSQDYKYIATQGPVTKTLVDFWRLIW
...|. || ..  |.  .   ...||... ||. ||. .||..| .|. |.  .       ||.||..|     | || |||..|.|. .| ||||....
vnnnklfrevlkrlsvpd..ldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvf

QEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
.||   |||.|...|...||| ||||. ||  ||.| . | |. .   ..|.|. |   .| .  ||.. | .  | . |      |...| . | .  .
dekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqte

PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
  |||..||||.|.|||..|.|.   ...|  |  .|. 
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1025-1246 4e-33 109.7 In-house 12-231 (307) alignment 
Range on Protein: 1025-1246
Range on HMM: 12-231/307.0
AKGNEGFRSQFGTLNSgENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNqIPGnrdCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEK
 || . .. .|  |    . ..||.   ..|   ||. .. . | .||... ..|      ||. | |.    .  |.|..|||  .|  .|| .. |||
dkgvqalvdefrvlak.ktpegvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiqek

PPVIVMVTNVKEEKKIKCHQYWPES-GS-TSYG--PFRIELT----KDQALSDYTIREMHLTLLGSdQPPLLITQYHFTSWPDHGVPEYATSILQFHRRI
   ..|. .| |  ||||.||||   |    .|  |  | ..    |  |  .  |    | .  . |    |... .. |||.|||.   . . .   .
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleav

KNEykptKGPMLVHCSAGVGRTGTFMAIDM
. .    . |..|||||||||.|| .|| .
ryd....tnpvvvhcsaGvGrsGtivaisl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1026-1260 2.5e-71 234.9 In-house 12-262 (301) alignment 
Range on Protein: 1026-1260
Range on HMM: 12-262/301.0
KGNEGFRSQFGTLNSGENeHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKP
| ...| .|. .|..||. .| |. ....||.|||| ||.|||||||.|.. |    ||..|.|| ||||||.  |.||.|||. |||||||||||||||
khsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

PVIVMVTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTKDQALSDYTIREMHLTLL--------------GSDQPPLLITQYHFTSWPDHGV-PEYATS
  |||||| ||..| ||.||||.|   |...||| ..|...|.. |..||.. ...                ||. .  ..|.. |.||..|| .|..| 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
.   .  |. . |. .||..||||..|.|.|.......|| |.  || .|..
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf
subfamily_PTPRN_pd Subfamily PTPRN 1026-1253 2.4e-51 169.2 In-house 26-253 (297) alignment 
Range on Protein: 1026-1253
Range on HMM: 26-253/297.0
KGNEGFRSQFGTLNSGENEHSVT-IAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYI-DGYSQDYKYIATQGPVTKTLVDFWRLIWQE
| .. .. .. .| . |.| |.. .| .. |   || .... ||..|. |..   . . ..||.||  | |   .   |||||||...|. |||...|..
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

KPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALS-DYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP
   |||..|...||   .|..|||. ||  |. . ..|  .   . || .| ..|  | ...    .||.|| |||..|||  | |.|.| |..   |. 
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnksyrG

TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEK
   |..||||.|.||||....||. |..  |
rscpivvhcsdGaGrtGvyilidlvlnrllk
subfamily_PTPRK_pd Subfamily PTPRK 1029-1261 1.9e-66 219.1 In-house 22-247 (314) alignment 
Range on Protein: 1029-1261
Range on HMM: 22-247/314.0
EGFRSQFGTLNSGenehsVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVI
 ||. .. .|  |        |  . |.  ||. .|. ||  |. | .| |  | ..||.|| .||.| .  ..|.||||. .|. |||||...|.   |
ygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasi

VMVTNVKEEKKIKCHQYWPESGSTsYGPFRIELTKDQALSDYTIREMHLTLLG-SDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
||.|...|. ..|| .|||| ... ||....|| . ..|... .| . .. |  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|..
vmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
.|||||| ||||||.|||. |. .|.|| .|. |
vvhCsaGaGrtGtfiaidivldmieregvvdvfn
subfamily_PTPN23_pd Subfamily PTPN23 1029-1257 1.6e-51 169.8 In-house 15-245 (288) alignment 
Range on Protein: 1029-1257
Range on HMM: 15-245/288.0
EGFRSQFGTLNSG----ENEHSVTIAVTQSNKplNRFANIVVYDDNRILLNqipgnrDCQNDYVNACYIDGYSQ-DYKYIATQGPVTKTLVDFWRLIWQE
 ..  .|  |..      ...|..|| . |.|  ||. .|. || ||. |.      . ..||.||... . |    ..||||.|  .|| |||......
taldkkfkeleqkqdkearkrsiaiaklysek..nrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

KPPVIVMVTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNE--
| .||||... .| .| |...||||.   ....|.... | . . .. .  |...|. |..|.    ..  ..||||..|||.   ..|||   ...   
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldevesaye

--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI
   ...| |..|||||||||||.|  .   ... ||. |.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1030-1261 1e-61 203.6 In-house 19-246 (515) alignment 
Range on Protein: 1030-1261
Range on HMM: 19-246/515.0
GFRSQFGTLnSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrdCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIV
 |  .|  |  | | .  |.|  . | . ||. ||. || .|. |. |  |   ..||.|| || ..  |  |||.|||   .. |||||..||..  |.
lfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevindn..PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttia

MVTNVKEEKKIKCHQYWPE--SGSTSYGPFRIELTKDQALSDYTIREMHLTlLGSDqpPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
|||. ||. |||| .|||.  . |  .| ...||   .| .. ..|.....  |.|     .||.||| |||.|||. ..|.|.. . .| .    . |.
mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl.kgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
..|||||||||| ...||  . .|..   .|. |
iihcsaGvGrtGvvisidsvvahakttrmvdvfn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1030-1274 1.9e-34 113.6 In-house 12-253 (281) alignment 
Range on Protein: 1030-1274
Range on HMM: 12-253/281.0
GFRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIV
 |. .|  |        .|.     |.  ||..|| . |  |. |.    |..   ||. | ||        || ||||  .|  ||||.||||.   ||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn.stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLlGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLV
|. .. | .. || .|.|          .. .. ...  . ..   .| |   .    |||.. .  |||  ||| .  .|.  |.|.        | ..
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl.syegetrlithwlwkewpdwqvpessevmlkilrkirarst....ppvi

HCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIINNKLGFTGKLTNPQ
||||||||.||.||... ||          |  |  .|  ||. .  |
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvq
0046845 (Phosphotyrosine protein) phosphatases II 1031-1260 2.8e-76 251.9 In-house 2-243 (284) alignment 
Range on Protein: 1031-1260
Range on HMM: 2-243/284.0
FRSQFGTLNSGENEH--SVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrDCQNDYVNACYIDGY-----SQDYKYIATQGPVTKTLVDFWRLIWQE
.. .| .|.|    .  |...|. . |. .||. .|..||..|. |. ..|. .  .||.|| |.|||      .  |.||||||. .|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPPVIVMVTNVKEEKKIKCHQYWPESG-STSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-
. .||||.|.  | ...||.||||..| .  ||.|...|.. .  .|||.|.. || || ..... .|..|.|||||||||......|.| | ... .. 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDII
 |..||..||||||||||||| |.|. |.| ||||   |.|. 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvl
DSPc_SM00195 1031-1259 1.9e-69 229.3 In-house 2-230 (263) alignment 
Range on Protein: 1031-1259
Range on HMM: 2-230/263.0
FRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrdCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVM
.. .| .|.. ......| |  ..||  ||. ||..||..|. |......   ..||.|| ||.|.... ||||||||  .|. ||||..|.|| ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTKDQALS-DYTIREMHLTLLGSdQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|..|.||..||||.  |.. .| ....|.. .  . ....|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDI
.|||||||||||||..||. |.. |.|  .||
vVhCsaGvgRtgtfvtidiilskleeekkvdi
PTPc_SM00194 1031-1259 1.9e-69 229.3 In-house 2-230 (263) alignment 
Range on Protein: 1031-1259
Range on HMM: 2-230/263.0
FRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNrdCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVM
.. .| .|.. ......| |  ..||  ||. ||..||..|. |......   ..||.|| ||.|.... ||||||||  .|. ||||..|.|| ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTKDQALS-DYTIREMHLTLLGSdQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|..|.||..||||.  |.. .| ....|.. .  . ....|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDI
.|||||||||||||..||. |.. |.|  .||
vVhCsaGvgRtgtfvtidiilskleeekkvdi
0045098 (Phosphotyrosine protein) phosphatases II 1031-1260 4.7e-67 221.6 In-house 9-240 (278) alignment 
Range on Protein: 1031-1260
Range on HMM: 9-240/278.0
FRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILlnqipgnrdcqnDYVNACYIDGYsqDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVM
....|  | .  .  ..| |.  .|...||. .|. || .|.             ||.|| |||||  . |.||||||  .|. ||||..|... .||||
lllefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

VTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLL---GSDQPPLLITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK----
.|...| ...||.|||||.||  ||.|...|.. . |.|||.| ...| |    .| ... .|..|...|||||||..   .|.|.. ..|.. .|    
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekEGGIDII
         . .||.|||||||||||||. |... |..   |||.|. 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdll
subfamily_egg_pd Subfamily egg 1031-1248 3.3e-25 83.4 In-house 16-225 (307) alignment 
Range on Protein: 1031-1248
Range on HMM: 16-225/307.0
FRSQFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLnQIPgNRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVM
.  ..  |.   .| |.| |... |.   |   .   |  |. | ... .    .|.. | ...|     ..| .| |.  |  ||||...||. . |||
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvkl.elr.rGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

VTNVKEEkkIKCHQYWPESGSTS--Y--GPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFtSWPDHGvpeYATSILQFHRRIKNEYKptkgP
.|  ||    .|. ||| . | |  .  | .|||  | .  .|   |  .| |.|.|.  . .  .    .   .      | |.  |...|  |    |
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlsk....p

MLVHCSAGVGRTGTFMAIDMGL
..|..  || ...|..||.. |
vvvqdilGvskaatlvaieial
subfamily_PTPN3_pd Subfamily PTPN3 1034-1257 2.3e-55 182.5 In-house 20-241 (280) alignment 
Range on Protein: 1034-1257
Range on HMM: 20-241/280.0
QFGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQipgnrdCQNDYVNACYID----GYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIV
|| .|   ... ....|    | . ||. .|. ||. |. |..       ..||.|| |..    . ..  .|||||||..||  |||...|..|  .||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklke......setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MVTNVKEEKKIKCHQYWPESG-STSYGPFRIELTKDQALSDYTIREMHLTLLGSDQpPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPML
|.|.. |. ..||||||||.. ...|| |.....|... . | .||. |.   ...    |.|  ...|||||||. ....|.| .|...  . .. |..
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvv

VHCSAGVGRTGTFMAIDMGLQQAEKEGGI
||||||.|||| ...... |.  |..  .
vhCsaGigrtGvlilletalalieaaepv
subfamily_PTPN13_pd Subfamily PTPN13 1035-1260 1.9e-52 173.3 In-house 17-238 (273) alignment 
Range on Protein: 1035-1260
Range on HMM: 17-238/273.0
FGTLNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrdcqndYVNACYIDGY--SQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVT
| .|.      ..... ...||  ||. |.. ||. |. |..  |       |.|| .|      . |.|||.|||. .|  |||...|. |  ||.|||
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NVKEEKKIKCHQYWPESGS---TSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLV
. ||..|.|||.||||| .   . .. ...|| | | |.....|..... . | .    ... .|..|||||||  |...||| .....  .  .||..|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
|||||.||.||...||. |.  |..  .|. 
hcsaGiGrsGtlitidvvlglierdkefdvk
subfamily_PTPN1_pd Subfamily PTPN1 1038-1260 6e-51 167.9 In-house 15-237 (290) alignment 
Range on Protein: 1038-1260
Range on HMM: 15-237/290.0
LNSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQipgnrdCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEE
..   ...... | ...|..|||. ..  ||  || |..       .|||.||  ..    . .|| ||||...|   ||...|..|   .||. .| |.
irkeasdfptreaklpenrnlnryrdvspydhsrikler......adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvek

KKIKCHQYWPESGS---TSYG--PFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVH
..|||.||||.  .     .    ....| . .  | ||.| ..|. | ...    |...|.|.||| ||||  .. |.|  ....    .. .|| ..|
eqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTGTFMAIDMGLQQAEKEGGIDII
||||.||.|||. .|  | . ||.. .. .
csaGiGrsGtfclvdtclvliekkddlssv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1039-1261 1.1e-58 194.0 In-house 45-261 (319) alignment 
Range on Protein: 1039-1261
Range on HMM: 45-261/319.0
NSGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTnvkeek
. | |    | |  . ||  ||. ||. .| |.. |... |      ||.|| ...|| .  ||||.|||   || ||||.||. .   ||..|      
klgvnladqtfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......

KIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVG
| || ||||  .   .. | ....  .  ..|..|...|.  |  .    |||.||  |||.|||.|.. .... ....     .  . ...||||||||
kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RTGTFMAIDMGLQQAEKEGGIDIIN
|||.....|. |.. ..|  .|. |
rtGvyivldvlldrmkeekqvdvyn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1040-1261 4.6e-58 192.0 In-house 10-225 (284) alignment 
Range on Protein: 1040-1261
Range on HMM: 10-225/284.0
SGENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTnvkeekK
 | |    | |  . ||  ||. .|. .| |.. |... |.     ||.|| .| || .  ||||||||   || ||||.||. .   ||..|      |
lgvngtdqtfanldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

IKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGR
 || ||||  .   .. |.....  .  ..|..|...|.  |  .    |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

TGTFMAIDMGLQQAEKEGGIDIIN
||.....|. |.. ..|  .|. |
tgvyivldvlldrmkeekqvdvyn
subfamily_PTPN12_pd Subfamily PTPN12 1042-1251 2.5e-60 198.8 In-house 27-234 (290) alignment 
Range on Protein: 1042-1251
Range on HMM: 27-234/290.0
ENEHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIK
|...| . . ...|.  ||. .|. || .|. |..| ..   ..||.|| .| | ... .|||.|||..||| ||||.||. .  ..||. .. | .|.|
ekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CHQYWPESGSTS--YGPFRIELTKDQALS-DYTIREMHLTLLGSDQpplLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRT
|..||||.| ..  .|.|...|....|.. |..|| ....  .  .    ..|.|.|.|||||||. |.|.|.. . ...  .  . |..||||||||||
CerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GTFMAIDMGLQQA
|| .|||.  .. 
Gtiiaidyvrell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1042-1151 1.9e-22 74.5 In-house 36-155 (350) alignment 
Range on Protein: 1042-1151
Range on HMM: 36-155/350.0
ENEHSVTIAVTQSNKplNRFANIVVYDDNRILLNQIPGNRD------CQNDYVNACYIDGY------SQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIV
 |.  ..  |    |  ||. ||. |. .|. |.. . . |        |||.|| |.           |.||||||.|. .|. ||...| . | .||.
snDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvil

MVTNVKEEKKIKCHQYWPESGS
..|.  |    ||..||.| . 
sltsdvelnlekcyrYWqegsy
subfamily_eak_pd Subfamily eak 1043-1217 3.2e-11 37.2 In-house 38-208 (332) alignment 
Range on Protein: 1043-1217
Range on HMM: 38-208/332.0
NEHSVTIAVTQSNKPLNRF-ANIVVYDDNRILLNQIPGNRDcqnDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIK
...  .| .|.  . .||   .|| || . . |     ||.    |.||  ..      ||| |  .  . .  ||... ..| | ||.. .  |.|  |
yqrllsisetarleavnrnvvkivpydrylvrltssqlnrl...GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

CHQYWPESG--STSYGPFRIELTKDQALSDYTIREMHLTlLGSDqpPLLITQYHFTSWPDHGVPEYAtSILQFHRRIK
  .|.|. .    ..| . .|  .    . .  | . |.  | .     .  |..  | .  .| |    | ... .|
sdkyfpdktreelkfGildverkefvkrniletrllels.kGne..thrvlhykvfGwtettlpkye.dflalrkvmk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1044-1260 3.4e-48 159.0 In-house 9-233 (270) alignment 
Range on Protein: 1044-1260
Range on HMM: 9-233/270.0
EHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYS-QDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKC
... ..  .  .| |||.|.|.     |. |...  . | .  |.|| |. |.. .. ||||..||.  || .|||.||.|| . |||.|...|. . ||
tsesdlpeaargkklnRyadiLPsPatRvrleel..eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

HQYWPESGST----SYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpllITQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVH
 .|||..  .    ..|  ..  ....  . | .....|.  |. .    .. .....|||||||. .       ..|.  | ...  | . |. |.|||
erYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerr...lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSAGVGRTGTFMAIDMGLQQAEKEGGIDII
||||||||||..|.|....  |... .|..
csaGvgRtGtlialDiavrlLeetkkvdvl
subfamily_PTPN14_pd Subfamily PTPN14 1044-1260 7.5e-45 148.2 In-house 38-265 (300) alignment 
Range on Protein: 1044-1260
Range on HMM: 38-265/300.0
EHSVTIAVTQSNKPLNRFANIVVYDDNRILLNQipgNRDCQNDYVNACYIDG--YSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIK
.  .. |  . |.. ||| ... |.|||. |.    ... ...|.||  |     .....||..|||. .|. |||...|...  .|||.|. .|. | |
dallstaklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CHQYWPESG----STSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPlLITQYHFTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPML
...|.|...    .  .| |..     .  . .. . ..|  | | .    .    .| ||||||||  .. |.. ....      |.    | .| |.|
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer.tvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
|||||||||||  .  |. ..  |..  ||| 
vhCsaGvGrtGvlilsdlliatlehneeidik
0049772 (Phosphotyrosine protein) phosphatases II 1044-1249 6.7e-34 113.4 In-house 35-237 (314) alignment 
Range on Protein: 1044-1249
Range on HMM: 35-237/314.0
EHSVTIAVTQSNKPLNRFANIVVYDdNRILLNQIPGNRdcqNDYVNACYIDGYsqdYKYIATQGPVTKTLVDF----------WRLI--WQEKPPVIVM-
|.....|    |.  ||. .|. .| ||  |.  |..     || || |.||.    |.||||||   |.|||          ||..  .. .. .||| 
eltilvadlflnrdknryldilpad.nrvilpglpvsg...sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------VTNVKEEKkikchQ-----YWPESGstsygpfrieltkdqalsdytireM-------HltllgsdqpPLLITQYHFTSWP
                     ... .             ....                                            . |. .|. . .|
rdevladelsrLdaAlgKtpllildgng.....neptaadlellk........................eelydpelf.........erlgikylripvp

DHGVPeYATSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQ
|...|     ...| . |..   ...|| ||||.||.||||||..... . 
Dgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1046-1260 6.3e-33 108.9 In-house 24-228 (267) alignment 
Range on Protein: 1046-1260
Range on HMM: 24-228/267.0
SVTIAVTQSNKPLNRFANIVVYDDNRILLnqipgnRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKkIkcHQY
 ..  ... |.  ||. . . |||.|. |      |. ...|.|| |..|| .  ..|.||.|. .|  ||. .| ..| ||||..|.| ... |  ...
tisqsiaeknqernrlddnlpyddtrvil......rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.i..rlf

WPES--GSTSYGPFRIELTKDQALSDYTIREMHLTLlgSDQPPLLITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFM
||     .  |  . .| . ..   || |  . | .   ..    .| |..  |      . |   .  |    ||. .    |..|.||.||||.|||.
wPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtfl

AIDMGLQQAEKEGGIDII
 ||  |..| .||  || 
vidsqleraktegvsdif
0040439 (Phosphotyrosine protein) phosphatases II 1047-1259 4.3e-67 221.6 In-house 3-214 (249) alignment 
Range on Protein: 1047-1259
Range on HMM: 3-214/249.0
VTIAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYW
...|  . ||..||. .|. || .|. |. .||     .||.|| ||||| .  ..|||||| ..|. ||||..|...  ||||.|. .| ...||.|||
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PESGSTSYGPFRIELTKDQALSDYTIREMHLTLLgSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAI
|..||. || |...|.. . ..|||.|...|| |  |.... ......|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |.
plggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DMGLQQAEKEGGIDI
.. |.| |||.|.|.
ylmleqlekelgvdl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1047-1249 5e-29 96.2 In-house 27-228 (285) alignment 
Range on Protein: 1047-1249
Range on HMM: 27-228/285.0
VTIAVTQSNKPLNRFANIVVYDDNRILLNqipgNRDcqNDYVNACYIDGYSQDY-KYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQY
.| .  ..|  |||.|.. . .. |..|.    |.|   ||. | ..    .|   ||.||||. .|| |||..|.|||   ..|.  . |    ||  |
ctytayeanpdlnryadvrcieetrvvlk....nhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPESG--STSYGPFRIELT--KDQALSDYTIREMHLTLL-GSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGT
.||       .| . | ||  |..|..   .  . ..    .   || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| |
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtat

FMAIDMGLQ
|. ||    
fvgidyati
0037934 (Phosphotyrosine protein) phosphatases II 1048-1257 4.5e-61 201.8 In-house 3-207 (243) alignment 
Range on Protein: 1048-1257
Range on HMM: 3-207/243.0
TIAVTQSNKPLNRFANIVVYDDNRILLnqipgnRDcqNDYVNACYIDGYSqdyKYIATQGPVTKTLVD----FWRLIWQEKPPVIVMVTNVKEEKKIKCH
.||  . |.. ||. .|. ||..|. |       .  .||.|| .|...    ..|||||| ..|. |    |||..|...  ||||.|. .| ...||.
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPesGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAGV
||||  |.. ||.|...|.. . |.|||.|...|. |. |....|...||...|||||||.  ...|.|.. ...         . ...||.||||||||
qywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFMAIDMGLQQAekegGI
|||||. |... |..     |.
gRtGtliaaylmllll....gv
0042113 (Phosphotyrosine protein) phosphatases II 1049-1259 2.6e-66 218.8 In-house 3-211 (245) alignment 
Range on Protein: 1049-1259
Range on HMM: 3-211/245.0
IAVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPE
.|  . ||..||. .|. ||..|. |. ..|  |  .||.||.|.||| .  |.|||||| ..|. ||||..|...  .|||.|.  | ...||.||||.
vallpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

SGSTSYGPFRIELTKDQALSDYTIREMHLTLLgSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMG
..|. || |...|.. . |.|||.|....| |  | ... ...||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|... 
gesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LQQAEKEGGIDI
|.|.|||.|...
leqlekelgvsl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1049-1213 8.9e-29 95.3 In-house 27-190 (297) alignment 
Range on Protein: 1049-1213
Range on HMM: 27-190/297.0
IAVTQSNKPLNRFANIVVYDDNRILLNQIPGNRdcqnDYVNACYID--GYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYW
 |  .|    ||. .|. .||.|. | . . .|    ||.|| |.      .|.||| .|||. .|. |||.|....   |||||....|. . ||  ||
sakrnsslrknryrdilatddtrvkllrviter....dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PESG--STSYGPFRIELTKDQALSdY-TIREMHLTLLGSDQpPLLITQYHFTSWPDHGVPEYATSILQFH
|..       | . .|   . .   . ..    |.|.  ..    ..   | ||||||||     . .|.
psvvqerlkagdvvveflsstsde.fdrviltelqliyrse.srvvrhvqflswpdhGvpsdledlvrfq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1050-1261 9.6e-67 219.8 In-house 4-212 (250) alignment 
Range on Protein: 1050-1261
Range on HMM: 4-212/250.0
AVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDCqnDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIkCHQYWPES
|   .||  ||.|.|. .|  |..|..  |....  ||.|| ...||..   .||||||...|..||||....||  .|||.||.||..|  .|||||  
akkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

GSTSYGPFRIELTKDQALSDYTIREMHLTLLgSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGL
... ||  ...| ...  .|||.|.. |.   . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  |
kaekyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

QQAEKEGGIDIIN
....||  .|. .
erlkkekvvdvfk
subfamily_CG7180_pd Subfamily CG7180 1050-1260 3.7e-50 165.2 In-house 37-259 (296) alignment 
Range on Protein: 1050-1260
Range on HMM: 37-259/296.0
AVTQSNKPLNRFANIVVYDDNRILLNQIPGNRDcqNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKiKCHQYWPES
.. . |.  ||  ..| || ||..|... |. .  .||.|| |.|.. .. .|| |..|...|. .||||...|.   .|..|.. . .| ....|||. 
glrkenreknrdvkvvPyDynRvvLekldGeek..sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GSTSYGPFRIELTKDQALSDYTIREMHLTLL---------GSDQPPLLITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCSAG
. . ||.. .|... . ... .||...||           . . .  .......| |.  . ||  ....... ||..      . .|..||..|..| |
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGTFMAIDMGLQQAEKEGGIDII
..|.| ..|||. |...|||. .|. 
asRsGvylaidanlelvekeeevdvF
subfamily_CG42327_pd Subfamily CG42327 1050-1219 5.5e-22 72.8 In-house 23-193 (319) alignment 
Range on Protein: 1050-1219
Range on HMM: 23-193/319.0
AVTQSNKPLNRFANIVVYDDNRILLNQIPGnrDCQNDYVNACYIDGYSQ-DYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPE
.|  . |. .|..|.|   . |. |..|.   | .. |..| |. || . .  |||.| .  ..  ||||..|. .  ||| .|.. |    .| .|.| 
evPvtskdksrvinvvPlPetrvvlqrigd..ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

S----GSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFtSWPDHGVPEYATSILQFHRRIKNE
.    .  .|| ... | . ..   | |  . |  .  ..    .| | .  |.. .||   ....    .... 
ketldntslyGdilvtlkgrevkdryaistlllkrvdkees.relthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1051-1254 2.8e-22 74.1 In-house 39-234 (288) alignment 
Range on Protein: 1051-1254
Range on HMM: 39-234/288.0
VTQSNKPLNRFANIVVYDDNRILLNqipgnRDCqNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPES-
.  .|   .|. |.   |  |. |.      |. . |..|  .     . . | .| |.  |.  .|... ..    |||.... |  | |  .|.|   
sfianptrdryenlprcditrvkls.....ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GST-SYGPFrIELTKDQAlsDYTIREMHLTLLG---SDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAID
| .  .| .    .|..   .   . ....||      . . .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. | 
Gekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlilil

MGLQQAEKE
. |...  .
ialeslrld
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1052-1261 2e-61 202.2 In-house 5-211 (239) alignment 
Range on Protein: 1052-1261
Range on HMM: 5-211/239.0
TQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQDYK-YIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESG
 . ||  ||.|||| || .|..|...  . | ..||.|| |.  |    | |||||| |. .  ||||..|||.  ||||.| . | .| |||||||.| 
krvnkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

StSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
|  |  .|. | | . ..|| || . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.|
s.kycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AEKEGGIDIIN
|.|.  .||.|
akkqktvdifn
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1052-1261 2.3e-61 202.0 In-house 4-210 (239) alignment 
Range on Protein: 1052-1261
Range on HMM: 4-210/239.0
TQSNKPLNRFANIVVYDDNRILLNQIpgNRDCQNDYVNACYIDGYSQDYK-YIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESG
 . ||  ||.|||| || .|..|...  . | ..||.|| |.  |    | |||||| |. .  ||||..|||.  ||||.| . | .| |||||||.| 
krvnkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

StSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
|  |  .|. | | . ..|| || . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.|
s.kycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AEKEGGIDIIN
|.|.  .||.|
akkqktvdifn
subfamily_ptpA1_pd Subfamily ptpA1 1052-1244 7.9e-34 112.1 In-house 44-249 (418) alignment 
Range on Protein: 1052-1244
Range on HMM: 44-249/418.0
TQSNKPLNRFANIVVYDDNRILLNQIPGNRdcQNDYVNACYIDGYSqDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPES--
 . |   ||..||.  .  |. |..|  .    .||.|| ||||     ..|.||||. .|. ||||..|...  .|||..   |. .||| .||||   
kkhntsknrytnilpvnhtrvqlkkiqdke..gsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

---------GSTSYGPFRIELTKD--QALSDYTIREMHLTLLGSDQPpllITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KPT---KGPMLVHCS
         |   .| . .|| .   .   .   |...||. |  .    ||||..  |||| .|...  . |. . | |      |.   . |..||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd...itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGVGRTGTFMAI
||||||||| . 
agvgrtgtfcta
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1053-1253 5.8e-14 46.2 In-house 49-247 (302) alignment 
Range on Protein: 1053-1253
Range on HMM: 49-247/302.0
QSNKPLNRFANIVVYDDNRILLNQipgnrdCQNDYVNACYIDGYSQDYKYIATQGPVTKTL---VDFWRLIWQEKPPVIVMVTNVKEEKKiKCHQYWP-E
..|   |.  .. ..|.|.. |..      ....||||  ..  .  .. | .| |....     .|||...|||   .|..   .| ||   ....| .
kknlkknqsedvpildsnlvklea......epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

SGS-TSYGPFRIELTKDQALSDYTiREMHLTLLGSDQP-PLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDM
||. . || ...   | .  .. .  .  . .|  .    .|.. |..| |... ||.  ... .    . ..  ... ....    |.|| |.|..  .
sgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

GLQQAEK
 ... .|
aveklqk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1053-1244 3.3e-08 27.5 In-house 45-231 (303) alignment 
Range on Protein: 1053-1244
Range on HMM: 45-231/303.0
QSNKPLNRFANIVVYDDNRILLNqipgnrdcQNDYVNACYIDGYSQDyKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGST
 .|   |||..... |  .. |         .  |. | |..  |.  | | || |...|  |||..| ..|  .....    | .|.  .  .|.    
vknmdknrfvdvicldhskvkls........dssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

-SYGP--FRIELTKDQALSDYTIreMHLTLLGSDQPPLLITQYHFTSWPDHGVPE-----YATSILQFHRRIKnEYKPTKGPMLVHCsAGVGRTGTFMAI
  .     |.   |   |.|     ...  .   .   ..  .|. .||   .|      .   | |    ..  | ... .. .   .|.||.|||  .
lkfeersirvgefkrvelgdgwv..lkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdstptvymsl.sgcgragtfalf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1054-1141 1.1e-10 35.5 In-house 33-117 (332) alignment 
Range on Protein: 1054-1141
Range on HMM: 33-117/332.0
SNKPLNRFANIVVYDDNRILLNqiPgnRDCQNDYVNACYIDGYSQDYKYIATQGPVT-KTLVDFWRLIWQEKPPVIVMVTNVKEEKKIK
 |  .||   . ..| .|. |   |  .| ..|. || ..||||.   || .| |.  .|   |||.. . || .|... .. |..| |
nnmdmnriphlycfdhsrvela..p..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
Y_phosphatase Protein-tyrosine phosphatase 1055-1260 3.7e-68 224.8 Pfam-A 1-206 (235) alignment 
Range on Protein: 1055-1260
Range on HMM: 1-206/235.0
NKPLNRFANIVVYDDNRILLnqipgNRDCQ-NDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWP--ESGS
||  ||. .|..||..|. |     . ... .||.|| |..||... |.||||||. .|. ||||..||||  ||||.|...|... ||.||||  |..|
nkkknRykdilpydktrvkl.....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TSYGPFRIELT-KDQ-ALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQ
..|| ...||. | . . ..||.|...|.  .... .  ..|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAEKEGGIDII
|.|.|. .|. 
qleaeeevdvl
Y_phosphatase Protein-tyrosine phosphatase 1055-1260 3.7e-68 224.8 In-house 1-206 (235) alignment 
Range on Protein: 1055-1260
Range on HMM: 1-206/235.0
NKPLNRFANIVVYDDNRILLnqipgNRDCQ-NDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWP--ESGS
||  ||. .|..||..|. |     . ... .||.|| |..||... |.||||||. .|. ||||..||||  ||||.|...|... ||.||||  |..|
nkkknRykdilpydktrvkl.....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TSYGPFRIELT-KDQ-ALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQ
..|| ...||. | . . ..||.|...|.  .... .  ..|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAEKEGGIDII
|.|.|. .|. 
qleaeeevdvl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1055-1262 1.2e-61 203.0 In-house 3-210 (237) alignment 
Range on Protein: 1055-1262
Range on HMM: 3-210/237.0
NKPLNRFANIVVYDDNRILLNQIPGNrdcqNDYVNACYIDGYSQ-DYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESG-ST
||  ||..|||.|| .|..|.   ..     ||.||.|..|.     ||||.|||.  .  |||...||||  ||||.| . | ...|||.|||..   .
nkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

SYGPFRIELTKDQALSDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
.|| . . |.|....||||.| . |.  .. .   || ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.|
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

AEKEGGIDIINN
|...  .|| | 
akekkvvdiyny
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1055-1261 9.3e-57 187.2 In-house 28-238 (274) alignment 
Range on Protein: 1055-1261
Range on HMM: 28-238/274.0
NKPLNRFANIVVYDDNRILLNQIPGNrDCQNDYVNACYIDGYSQDYK-YIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGST-
..  ||. .|.  .  |.||..  .. | . .|.|| || ||... | |.|||||...|. ||||.|.||. .||||.|..||... ||..|.|.. .. 
sqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---SYGPFRIELTKDQALSDYTIREMHLTLLGSDQPpllITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSAGVGRTGTFMAIDM
    || . |. .|     ||..|.. |  | . .    .. | .|.|||| .|. |...|.. . ....    .   .|..||||||.|||| |.||..
iserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

GLQQAEKEGGIDIIN
...| ..|. .|...
avrqlreeivvdvlk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1055-1259 1.3e-41 137.3 In-house 38-245 (287) alignment 
Range on Protein: 1055-1259
Range on HMM: 38-245/287.0
NKPLNRFANIVVYDDNRILLNQIPgnrDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGS-TS
.   ||.|... .||.|.|| . .   .   ||.|| |. .| .| ..||.|||.. |. ||||......  .....|   || . ||..||||      
avkknryadvlPiddtrvllsaeg...elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmr

YGPFRIE-LTKDQALSDYTIREMHLTLLGSDQPpLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMG
 | . .  | .|.   .|..| . |  | . .   .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . 
vGGysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LQQAEKEGGIDI
... |. | .|.
vsrledlGrvdv
0041856 (Phosphotyrosine protein) phosphatases II 1055-1250 7.2e-40 131.9 In-house 1-135 (182) alignment 
Range on Protein: 1055-1250
Range on HMM: 1-135/182.0
NKPLNRFANIVVYDDNRillnqipgnrdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTnvkeekkikCHQYWPesgstsy
|...||. .|. || .|             .||.|| ...|.  . ..||||||  .|. ||.|......  .||..|         ...|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfrieltkdqalsdytiremhltllgsDQPPLLITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
                            .  . |..||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1055-1250 1.6e-26 87.7 In-house 55-247 (305) alignment 
Range on Protein: 1055-1250
Range on HMM: 55-247/305.0
NKPLNRFANIVVYDDNRILLNQIPgnrdcQNDYVNACYIDG-YSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGS--
..  ||.... . | . ..|.. .       ||. | |.      . ..|..|||. .|. .|| .. |.|   |||. .  |  |.|| |||| .    
aitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

-TSYGPFRIELT-KDQAL-SDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGL
 .  .   .|     . .  |  |.   | |  | .  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||.  |
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyil

QQ
..
ek
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1055-1245 1.2e-18 61.9 In-house 43-230 (312) alignment 
Range on Protein: 1055-1245
Range on HMM: 43-230/312.0
NKPLNRFANIVVYDDNRILLNqipGNrdcQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPES-GST-
 | |||. || ..|  |. |    |.   .| |. | ..   ..  ....||||. .| . ||.|        |.... . |.   || .|  .  |   
fkdlnrypniqcwdrgrftla...gd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

-----SYGPFRIELTK-DQALSDYTIREMHLTLLGSDQPPLLiTQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAID
      |  .  |.    ..    | | ... .  . |   |  .| ..||||||.|.   . |..   .|..    | |.. |||||||||||.. |.
ledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl.nhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtlalie
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1055-1140 6.8e-07 23.1 In-house 37-125 (347) alignment 
Range on Protein: 1055-1140
Range on HMM: 37-125/347.0
NKPLNRFANIVVYDDNRILLN---QIPGNRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKI
.   ||  .  . |. |..|       .. |  . |.|| .|     . .|| || |. .|. |||...   |   .| . . .... |
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1057-1250 8.7e-37 121.3 In-house 58-242 (290) alignment 
Range on Protein: 1057-1250
Range on HMM: 58-242/290.0
PLNRFANIVVYDDNRILLNQipgnrDCQNDYVNACYIDGYSQdyKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESG--STSY
  ||. ..|  |  |..|..       . ||| | |..|      .| |||....| .|.||.. |||  .|||. .. |. | ||.||.||      ..
kknrykdvvcndktrvilkd.....GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GPFRIELTKDQALSDYTIREMhLTLLGSDQP-PLLITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
| . .  ....   . .|. . |..   |.     .  ..  ||||. |.  . ..|.  | ...    . ||. ||||||.||||||.||..||| 
Geitvlcseeddkdaniikkt.lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1059-1161 2.1e-13 44.3 In-house 52-165 (349) alignment 
Range on Protein: 1059-1161
Range on HMM: 52-165/349.0
NRFANIVVYDDNRILLNQIPGNR-----------D-CQNDYVNACYID--GYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQ
||. .|. |.  |. |.. . .                .||.|| |.    .| . |||||| |.  |. ||...|  .. .... ... ||.   ||..
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPESgstSYGPFRIEL
|| |    ||  ... |
ywqel...sysnitvkl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1066-1251 4.5e-18 60.4 In-house 29-218 (290) alignment 
Range on Protein: 1066-1251
Range on HMM: 29-218/290.0
VYDDNRILLNQIpgNRDCQNDYVNACYIDgYSQDYKYIATQGPVTKT-------LVDFWRLIWQEKPPVIVMVTNVKEEKKI----KCHQYWPESGS--T
.  ..|. |..    .  ..||. | ..  .... . |.|| | .|.       . .|| .. |||   .||. ...|...      | .| |||     
LveatrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

SYGPFRIELTKDQALSDYTIREMHLTLlgSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQA
 .. . .. ..  .  |  .||. ..    |. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||..| |  
kfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQki
0044763 (Phosphotyrosine protein) phosphatases II 1070-1249 4.5e-29 96.8 In-house 5-135 (178) alignment 
Range on Protein: 1070-1249
Range on HMM: 5-135/178.0
NRILLNQIPGNRDcqNDYVNACYIDGYsqdyKYIATQGPvtktlVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGStsygpfrieltkdqalsd
.| ||. ..|      || ||..|...     |.....|     .|...|.....  .||..|. .|  ..||..||||. .                  
trvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

ytiremhltllgsdqpplliTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQ
                     ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1080-1163 1.6e-07 25.6 In-house 8-86 (130) alignment 
Range on Protein: 1080-1163
Range on HMM: 8-86/130.0
NRDCQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKkikchQYWPESGSTSYGPFRIELTK
.|  .|.|.|| ..    .  .|. || |...| .|||... .    |.|..  |.||      .|||.|    .   .| .| 
srlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtl
0046846 (Phosphotyrosine protein) phosphatases II 1083-1248 2.7e-34 113.8 In-house 10-133 (176) alignment 
Range on Protein: 1083-1248
Range on HMM: 10-133/176.0
CQNDYVNACYIDGYsqdyKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYgpfrieltkdqalsdytiremhltllgs
   ||.|| .|.|.    ..||||||. .|| ||........  ..|..|. .| ...||..||||  . ..                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

dqppllitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGL
        ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |...  
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaaylle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1083-1151 5e-09 30.1 In-house 120-183 (244) alignment 
Range on Protein: 1083-1151
Range on HMM: 120-183/244.0
CQNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKkikchQYWPESGS
  | |.|| ..    .  .|| || |.. | .|||... . .  |.|..  |.||      .|||.|  
mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdsep
0043147 (Phosphotyrosine protein) phosphatases II 1084-1248 2.9e-33 110.4 In-house 4-124 (172) alignment 
Range on Protein: 1084-1248
Range on HMM: 4-124/172.0
QNDYVNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVkeekkikchqywpesgstsygpfrieltkdqalsdytiremhltLLGSD
 .||.|| |.|.|    ..||||||   || ||||......  .||..|.                                             |.  .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpe

QPPLLITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
.   |. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml
0051429 (Phosphotyrosine protein) phosphatases II 1085-1258 1.2e-42 141.7 In-house 4-184 (272) alignment 
Range on Protein: 1085-1258
Range on HMM: 4-184/272.0
NDYVNACYIDGYSQ---DYKYIATQGPVTKTLVDFWRLiWQEKPPVIVMVTNVKEEKKIKCHQYWP------------ESGSTSYGPFRIELTKDQALSD
..|.|| ...|| .   . ......|| . |  ||||| ....  .||..... | .. ||..|||            .  . .|| .|. |.. . |.|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID
|..||. |||| | . .. ....|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivd
0036282 (Phosphotyrosine protein) phosphatases II 1085-1260 1.6e-37 124.3 In-house 2-139 (174) alignment 
Range on Protein: 1085-1260
Range on HMM: 2-139/174.0
NDYVNACYIDGYSQDYKYIATQGPVTktlvdFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPEsgstsygpfrieltkdqalsdytiremhltllGSDQ
.|| || ..|..    ..||.||| .     ||.......  ..||... || .. ||..||||                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PPLLITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDII
.  |. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdal
0051082 (Phosphotyrosine protein) phosphatases II 1085-1251 9.7e-30 98.5 In-house 3-119 (151) alignment 
Range on Protein: 1085-1251
Range on HMM: 3-119/151.0
NDYVNACYIDGYsqdykYIATQGPVTktlvDFWRLIWQEKPPVIVMVTNVKEEKkiKCHQYWPESGstsygpfrieltkdqalsdytiremhltllgsdq
.|| |. |..|.     .....||      ||..|.....  .||.... .| .  .|..|.|| |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ppLLITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
  . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |.. 
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllgv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1088-1257 2.1e-24 80.8 In-house 78-247 (301) alignment 
Range on Protein: 1088-1257
Range on HMM: 78-247/301.0
VNACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGST--SYGPFRIELTKDQALSDYTIREMHLTLLG--SD
. | .|.   .  ..||||||...|  ||| .. | .   |||...  |... ||..| | . |     | |.|.... . . .  | . .| .     .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

QPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI
 ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |
fatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadpti
0049260 (Phosphotyrosine protein) phosphatases II 1092-1248 1.9e-33 110.7 In-house 1-113 (152) alignment 
Range on Protein: 1092-1248
Range on HMM: 1-113/152.0
YIDGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWpesgstsygpfrieltkdqalsdytiremhltllgsdqppllitQ
.|||| . ...||||||   || ||||.... .  .|||.|.  | .|.||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
|... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1094-1173 2.5e-10 34.3 In-house 230-307 (440) alignment 
Range on Protein: 1094-1173
Range on HMM: 230-307/440.0
DGYSQDYKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEeKkiKCHQYWPE-SGSTSYGPFRIELTKDQALSDYTIR
.|||.   .|||| |.  |..|||||. . .   |.|. .... |   |  |||  . | ..||| .     . .    .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd.k..tcsiywpvntrsvtfgpftvghkgsenmnrvkvr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1100-1253 3.5e-24 80.1 In-house 5-164 (199) alignment 
Range on Protein: 1100-1253
Range on HMM: 5-164/199.0
YKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWP--ESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPP-LLITQYHFTS
 .||||| |. .|. |||...|.     |||| . . .|.     |||  |||.. || . .      . .||||  . ||   .  |    |..| |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAEK
| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1100-1253 4e-24 79.9 In-house 4-163 (198) alignment 
Range on Protein: 1100-1253
Range on HMM: 4-163/198.0
YKYIATQGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWP--ESGSTSYGPFRIELTKDQALSDYTIREMHLTLLGSDQPP-LLITQYHFTS
 .||||| |. .|| |||...|.     |||| . . .|.     |||  |||.. || . .      . .||||  . ||   .  |    |..| |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAEK
| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1106-1260 1.5e-17 58.0 In-house 97-257 (302) alignment 
Range on Protein: 1106-1260
Range on HMM: 97-257/302.0
QGPVTKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPES--GSTSYGPFRIELTK-DQALSDYTIR--------EMHLTLLgSDQPPLLITQYHF
  |  .||  .| || | .  ..| .....|... || .|. .   |   .| . ..  . .. |...| .        |.. .    .. .  .   .|
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk.kkkvkktvdilaf

TSWPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
..||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..
sawpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdll
subfamily_hpo-7_pd Subfamily hpo-7 1110-1249 1.6e-14 48.5 In-house 44-179 (263) alignment 
Range on Protein: 1110-1249
Range on HMM: 44-179/263.0
TKTLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTL-LGSDQPPLLITQYHFTSWPDHGVPEYATS
 .|.  |.. | | |. |.||... .|| . || .|.|           ....  .. ||  ..  .|.  ||  .    ...| .. |...  || | .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

ILQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ
||.  .  .|  |    .. ||||.|.||.  |  ...  |
ilnilkvarns.k....slvvhcstGiGrsaafsvaElvyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1112-1249 1.2e-17 58.9 In-house 40-173 (255) alignment 
Range on Protein: 1112-1249
Range on HMM: 40-173/255.0
TLVDFWRLIWQEKPPVIVMVTNVKEEKKIKCHQYWPESGSTSYGPFRIELTKDQALSDYTIREMHLTL-LGSDQPPLLITQYHFTSWPDHGVPEYATSIL
|.  |.. | | |. |.||... .||.. ||..|.|           ...|  .. .|  .| ...|. ||  .    .. |... |...  || |  ||
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ
.  . ...  |    ...||||.|.||. .|. ...  |
nilkvvrds.k....svvvhCstGiGrsaafvlaelvyq
0048076 (Phosphotyrosine protein) phosphatases II 1168-1249 6.3e-19 63.5 In-house 26-106 (145) alignment 
Range on Protein: 1168-1249
Range on HMM: 26-106/145.0
SDYTIREMHLTLLGSDQPPLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGLQ
 |. |.         . .  |..||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..|... |.
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1178-1288 6.7e-11 36.5 In-house 208-323 (350) alignment 
Range on Protein: 1178-1288
Range on HMM: 208-323/350.0
TLLGSDqpPLLITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIINNKLGFT
||  ||  |. . | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |.. |    .    .||  .
tlaasd..PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

GKLTNPqtILLVIEEmYRTQR
 |. ..  |  .. | .| ||
aktrDl..isiivne.lrkqr
0048179 (Phosphotyrosine protein) phosphatases II 1186-1248 1.9e-18 62.0 In-house 46-107 (144) alignment 
Range on Protein: 1186-1248
Range on HMM: 46-107/144.0
PLLITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGL
   ..||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... .
eregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1188-1249 4.1e-07 23.6 In-house 219-290 (349) alignment 
Range on Protein: 1188-1249
Range on HMM: 219-290/349.0
LITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ
 . |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
PTPc_DSPc_SM00012 1189-1258 1.1e-23 78.8 In-house 2-74 (105) alignment 
Range on Protein: 1189-1258
Range on HMM: 2-74/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG-GID
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| |||   .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1189-1261 7.4e-15 49.2 In-house 91-164 (440) alignment 
Range on Protein: 1189-1261
Range on HMM: 91-164/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIN
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||..
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifs
0038934 (Phosphotyrosine protein) phosphatases II 1191-1243 2.7e-07 25.9 In-house 81-134 (194) alignment 
Range on Protein: 1191-1243
Range on HMM: 81-134/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMA
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. |
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
PTEN_1 1192-1241 3.6e-06 21.9 In-house 97-147 (196) alignment 
Range on Protein: 1192-1241
Range on HMM: 97-147/196.0
YHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
ylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
subfamily_CG42327_pd Subfamily CG42327 1221-1259 1e-08 29.3 In-house 244-283 (319) alignment 
Range on Protein: 1221-1259
Range on HMM: 244-283/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDI
.  .||. |||| ||||||. .| |. ... |.    .||
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1227-1262 9.1e-08 26.4 In-house 1-36 (69) alignment 
Range on Protein: 1227-1262
Range on HMM: 1-36/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIINN
|.||||.| ||||||.|| . . .   |  .|| ||
mvvhcssgtgrtgtfiaimvemarikseklvdifnn
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1229-1262 4.1e-07 24.2 In-house 2-35 (69) alignment 
Range on Protein: 1229-1262
Range on HMM: 2-35/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIINN
||||.| ||||||.|| . . .   |  .|| ||
vhcssGtGrtGtfiaimvemarikseklvdifnn
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1267-1366 2.5e-57 188.9 In-house 191-290 (290) alignment 
Range on Protein: 1267-1366
Range on HMM: 191-290/290.0
TGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
|||.||||||||||||||.||||||||||||||||||.|||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1267-1368 2.4e-55 182.5 In-house 186-287 (287) alignment 
Range on Protein: 1267-1368
Range on HMM: 186-287/287.0
TGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
|||.|.||||||||||||.|||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||.||..|..|||.|||||||||
tgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

NF
.|
df
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1268-1364 3.9e-25 83.6 In-house 192-288 (305) alignment 
Range on Protein: 1268-1364
Range on HMM: 192-288/305.0
GKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
|  . . ..| .|... ..|.|  .....||||..|.|. .|.|    ....|.|.|.|||.|||  | .... ||| .||. .....  .. ...|
GvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1268-1367 5.3e-21 70.0 In-house 189-288 (318) alignment 
Range on Protein: 1268-1367
Range on HMM: 189-288/318.0
GKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
| .... ..| .. .  ..|.| |.. ||||||  | |  .|.|  . ... | |...||||. |  | |..  ||| .||. |....| .| |..|. .
gvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_PTPRD_pd Subfamily PTPRD 1268-1365 1.4e-20 68.5 In-house 191-287 (564) alignment 
Range on Protein: 1268-1365
Range on HMM: 191-287/564.0
GKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
|  ......| .|... ... ....  ||||||  | |. .|..    ... |.|...|..|..|  | |..  ||| .||. |....| .|....| 
gvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1269-1367 7.3e-32 105.3 In-house 203-301 (301) alignment 
Range on Protein: 1269-1367
Range on HMM: 203-301/301.0
KLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
 . .|.|.| ||...  .|.| |   .||||||||||| ..|.   ..  || |||.||||| |. | .||| |.| .||  |.... .||   .||.|
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1270-1360 2.5e-11 38.1 In-house 174-265 (270) alignment 
Range on Protein: 1270-1360
Range on HMM: 174-265/270.0
LTNPQTILLVIEEMYRTQRKRGN-TSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
 .... .| ..... |....  . . ..||||. | |. .. |  ....  .... .|| ....  | ...  ||...||. ... |..| .
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0046845 (Phosphotyrosine protein) phosphatases II 1271-1367 9.7e-20 66.5 In-house 182-282 (284) alignment 
Range on Protein: 1271-1367
Range on HMM: 182-282/284.0
TNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
..|. .|  .... . ...  |.  ||||||. |.|...|.|. . ..  ..||   ..||....|  | |.||.|||..||. .....| || .. |. 
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

N
.
e
0036941 (Phosphotyrosine protein) phosphatases II 1271-1365 8.5e-19 63.4 In-house 185-283 (297) alignment 
Range on Protein: 1271-1365
Range on HMM: 185-283/297.0
TNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
..|...|  ||.. . ...  ... ..||||. |.||..|.|| . ..  .   .|| .|.....|. | |.||.|||..||. . ...| .| ...|.
espaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
PTPc_DSPc_SM00012 1271-1355 8.2e-17 56.7 In-house 17-103 (105) alignment 
Range on Protein: 1271-1355
Range on HMM: 17-103/105.0
TNPQTILLVIEEMYRTQRKRG-NTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
.... || ..... . ..|.. ....|||||. |.|...|.|... ......| . .|.||..|. | |.||.||| .||. . ...
eesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
0042113 (Phosphotyrosine protein) phosphatases II 1271-1359 1.2e-16 56.4 In-house 155-243 (245) alignment 
Range on Protein: 1271-1359
Range on HMM: 155-243/245.0
TNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
......| ..|.. . ... .|. ..||||. |.|...|.|| . ..  ..|. .......|  | |.||.||| .||. . ...| .|
dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 1271-1358 5.2e-13 44.6 In-house 150-241 (243) alignment 
Range on Protein: 1271-1358
Range on HMM: 150-241/243.0
TNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSDTVSRSAMFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTY
..|. .|  ..|..  ...        ..  ..||||  |.|.....|| . . ..   | .|.....|  | |.|| .||| .||. . ...| .
dspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1272-1365 1.8e-24 81.5 In-house 203-296 (298) alignment 
Range on Protein: 1272-1365
Range on HMM: 203-296/298.0
NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
| ...| ..... ..|.. ||....|.||. | ||  |.|  . ... |.| |.|||||.|  |...||.||| .||  |...|| .||||...
natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0050432 (Phosphotyrosine protein) phosphatases II 1272-1366 4.3e-20 67.7 In-house 215-306 (308) alignment 
Range on Protein: 1272-1366
Range on HMM: 215-306/308.0
NPQTILLVIEEMYRTQrkrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
.|. .|  .|.. ...   ..  ||||||. |.|.. |.|. . ..  ..|| .|||...|  | |.||.|||..||. .....| || ...|. 
speilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
Y_phosphatase Protein-tyrosine phosphatase 1272-1356 1.7e-18 62.3 Pfam-A 151-234 (235) alignment 
Range on Protein: 1272-1356
Range on HMM: 151-234/235.0
NPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
.|. .| .|... ... .  ....|||||. |.|...|.|. . ......|. .||.|..|. | |.||.||...||. . ...|
spkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1272-1356 1.7e-18 62.3 In-house 151-234 (235) alignment 
Range on Protein: 1272-1356
Range on HMM: 151-234/235.0
NPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
.|. .| .|... ... .  ....|||||. |.|...|.|. . ......|. .||.|..|. | |.||.||...||. . ...|
spkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0040438 (Phosphotyrosine protein) phosphatases II 1272-1365 1.7e-18 62.4 In-house 190-282 (317) alignment 
Range on Protein: 1272-1365
Range on HMM: 190-282/317.0
NPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
.|...|  .|.. . .. .... ..||||. |.|...|.|| . .. ...|| .||....|  | |.||.||| .||. . ...| ||  ..|.
spdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_PTPRA_pd Subfamily PTPRA 1272-1358 2.3e-18 61.2 In-house 209-294 (330) alignment 
Range on Protein: 1272-1358
Range on HMM: 209-294/330.0
NPQTILLVIEEMYRTQRKRGNtSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
.|. .| ..... ..... .. .||||||  | |.  |..  . ... |.|...|||...|. | |.|  ||| .||. |....| |
epiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0047943 (Phosphotyrosine protein) phosphatases II 1272-1359 5.8e-18 60.8 In-house 184-272 (273) alignment 
Range on Protein: 1272-1359
Range on HMM: 184-272/273.0
NPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
... .|  ||.. .....  .|. .|||||. |.|...|.|. . ..  ..|| .||....|  | |.||.|||..||. . ...| ||
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 1272-1363 2.1e-17 59.0 In-house 201-293 (297) alignment 
Range on Protein: 1272-1363
Range on HMM: 201-293/297.0
NPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
.....| ..|.. . ...  ... ..||||. |.|...|.|| . .. ...|| .||....|  | |.||.||| .||. .....| .|  . 
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 1272-1359 6.2e-17 57.7 In-house 213-304 (307) alignment 
Range on Protein: 1272-1359
Range on HMM: 213-304/307.0
NPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.....|  |||. . ...  ... ..||||. |.|...|.|| . .   ..||.   .|.....|  | |.||.||. .||. . ...| .|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 1272-1359 7.9e-17 56.8 In-house 176-262 (263) alignment 
Range on Protein: 1272-1359
Range on HMM: 176-262/263.0
NPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
... .| ...... ....  .. ||||||. |.|...|... . ..|...|  .|.|...|. | |.||.||| .||. | ...| |.
stksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1272-1359 7.9e-17 56.8 In-house 176-262 (263) alignment 
Range on Protein: 1272-1359
Range on HMM: 176-262/263.0
NPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
... .| ...... ....  .. ||||||. |.|...|... . ..|...|  .|.|...|. | |.||.||| .||. | ...| |.
stksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 1272-1359 2e-15 52.5 In-house 158-246 (249) alignment 
Range on Protein: 1272-1359
Range on HMM: 158-246/249.0
NPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.....|  ||..   ...   .. ..||||. |.|...|.|| . ..  ..|. .|.....|  | |.||.||. .||. . ...| .|
sfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1272-1360 6e-14 46.8 In-house 179-269 (274) alignment 
Range on Protein: 1272-1360
Range on HMM: 179-269/274.0
NPQTILLVIEEMYRTQRKRGNT--SIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
...|.| ...|. ...... .   ..|||||  . |  .| |.  .... . |.|.||...    |... | ||| .||. |....  || 
dantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1272-1356 7.1e-12 40.2 In-house 203-288 (319) alignment 
Range on Protein: 1272-1356
Range on HMM: 203-288/319.0
NPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 |  .. ...   . |........||||||  | |. .. .  . ... | |  .||.....  | |..  || . ||. |.  .|
ypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1272-1356 8.1e-12 40.2 In-house 167-252 (284) alignment 
Range on Protein: 1272-1356
Range on HMM: 167-252/284.0
NPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 |  .. ...   . |........||||||  | |. .. .  . ... | |  .||.....  | |..  || . ||. |.  .|
ypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
0043147 (Phosphotyrosine protein) phosphatases II 1272-1352 5.7e-11 37.9 In-house 80-154 (172) alignment 
Range on Protein: 1272-1352
Range on HMM: 80-154/172.0
NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVQQYQGIF
... .| ..| ... . .. .  ..||||  |.|.....||   .        . .......  | ..||.||. .||. . 
llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 1273-1359 3.6e-18 61.5 In-house 201-286 (288) alignment 
Range on Protein: 1273-1359
Range on HMM: 201-286/288.0
PQTILLVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|. .|  ...... ..  |.  .|||||. |.|...|.|. . ..  ..||..||....|  | |.||.|||..||. .....| ||
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1273-1359 8e-17 57.0 In-house 192-277 (278) alignment 
Range on Protein: 1273-1359
Range on HMM: 192-277/278.0
PQTILLVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
....|  .... . ..   |. ..||||. |.|...|.|. . ..  ..|| .|.....|  | |.||.||| .||. .....| ||
lsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 1273-1362 1.4e-13 45.7 In-house 201-289 (307) alignment 
Range on Protein: 1273-1362
Range on HMM: 201-289/307.0
PQTILLVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
....| .||...  ...  .. ||||||  |.||..| | .  ....|.|  .|.|.. |  | |..  ||  .||. ... .| | .  
argllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
0036282 (Phosphotyrosine protein) phosphatases II 1273-1353 2.3e-13 45.7 In-house 86-164 (174) alignment 
Range on Protein: 1273-1353
Range on HMM: 86-164/174.0
PQtILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
.. .| ....... . . ..  ..||||  |.|.....||   .   . |...|........| |.||.||| .||. . .
si.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPRB_pd Subfamily PTPRB 1273-1361 5.7e-12 40.3 In-house 198-287 (293) alignment 
Range on Protein: 1273-1361
Range on HMM: 198-287/293.0
PQTILLVIEEMYRTQ-RKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
..|.|  .... ... ..  .. ||||||  | |.  | |  . ... ..| ..|.| .. . | ..   |||..||  | | ||..| .
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN12_pd Subfamily PTPN12 1273-1359 6.9e-12 39.8 In-house 189-277 (290) alignment 
Range on Protein: 1273-1359
Range on HMM: 189-277/290.0
PQTILLVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
....| .||.. |. ... .. .|||||  | |    .|   . .  |.| .   .|||... . | |..  ||| .||. ... |. ..
aksllelielv.relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN6_pd Subfamily PTPN6 1273-1361 2.9e-11 37.9 In-house 205-299 (306) alignment 
Range on Protein: 1273-1361
Range on HMM: 205-299/306.0
PQTILLVIEEMYRTQRKR---GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
|...|  .|.. | |..     . .||||||. . |   |    . ... ...|.   ||. .. || | |. | ||| |||. ..... .|...
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN13_pd Subfamily PTPN13 1273-1361 4.2e-10 34.3 In-house 185-271 (273) alignment 
Range on Protein: 1273-1361
Range on HMM: 185-271/273.0
PQTILLVIEEMYRTQRkrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.. .| .. |. | |.   .. ||||||  . || .. .  . ..  . .  .|| ..... | |. | ||| .||  .....|. | |
aaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1274-1367 6.1e-23 76.3 In-house 157-250 (250) alignment 
Range on Protein: 1274-1367
Range on HMM: 157-250/250.0
QTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
...| ..... ..|.. ||. ..|.||  |.||  |.|  . ... |.| |.|||.|.|  |...|..|.. .||  ...|.| .|||.| |..
tavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1274-1364 2.7e-21 71.0 In-house 198-288 (319) alignment 
Range on Protein: 1274-1364
Range on HMM: 198-288/319.0
QTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
...| ..... ....|  .  ||||||. | |   |..   .... | |||.|||.. .  |.|..  ||. .||. |....| ......|
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1274-1364 7.7e-14 46.5 In-house 199-289 (297) alignment 
Range on Protein: 1274-1364
Range on HMM: 199-289/297.0
QTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
...| .|.|.  .  .. .. ..|||.  | | .....    . . | |  .|.|...|  | ..|  ||| .||. ....|| .| | .|
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1274-1361 2e-12 41.8 In-house 190-278 (281) alignment 
Range on Protein: 1274-1361
Range on HMM: 190-278/281.0
QTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
. .|   .|......|. ....|.|||  | |.  . |  . ......|   .|| .|... | ..   |||| ||. ....|| .|| 
kellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
0048076 (Phosphotyrosine protein) phosphatases II 1274-1356 3.1e-09 32.2 In-house 65-140 (145) alignment 
Range on Protein: 1274-1356
Range on HMM: 65-140/145.0
QTILLVIEEMYRTQRKrGnTSIVVHCSDTVSRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
...| ..| . . ... |   ..||||  |.|.....||   .     .| ......|.  | | ||.|....|.. ... .|
ellleflefieealke.g.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 1274-1352 1.3e-08 30.3 In-house 67-138 (144) alignment 
Range on Protein: 1274-1352
Range on HMM: 67-138/144.0
QTILLVIEEMYRTQRkrGNTSIVVHCSDTVSRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. .| ..| . . ..   .  ..||||  |.|.....||   .    ..| ......|.  | . ||.|.. .|.. . 
ellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
subfamily_PTPRK_pd Subfamily PTPRK 1275-1357 1.9e-14 48.2 In-house 194-275 (314) alignment 
Range on Protein: 1275-1357
Range on HMM: 194-275/314.0
TILLVIEEMYRTQRKrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
..| .. ..  .| . ..  ||||||    |. .|.| .. ..  ..|||.|||.. |. | .|.  |.| .||. |....| 
gllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0049260 (Phosphotyrosine protein) phosphatases II 1275-1352 1.3e-10 36.7 In-house 72-143 (152) alignment 
Range on Protein: 1275-1352
Range on HMM: 72-143/152.0
TILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
 .|| . .. .  ... .  ..||||  |.|.....||   .        ........  | ..||.|.. .|.. ..
qlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1275-1359 2.8e-10 34.1 In-house 110-194 (440) alignment 
Range on Protein: 1275-1359
Range on HMM: 110-194/440.0
TILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 .| .|...  .| | ||  ..||||  ..|...  |  . . ..|    ||.| ...| | ..|  ||| .||  ... ||  |
pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegl
0045098 (Phosphotyrosine protein) phosphatases II 1276-1360 5.8e-15 50.9 In-house 178-273 (278) alignment 
Range on Protein: 1276-1360
Range on HMM: 178-273/278.0
ILLVIEEMYRTQR------------KRGNTSIVVHCSDTVSRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTYLD
.| ..|.. . ..              ... ..||||  |.|.....|| . .  .  ||..|.....|  | |.|| .||. .||. ... .| .| 
flellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN23_pd Subfamily PTPN23 1276-1359 5.7e-13 43.3 In-house 196-280 (288) alignment 
Range on Protein: 1276-1359
Range on HMM: 196-280/288.0
ILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.| ..|..|...... .| .|||||  | |. .|.   . ... .  .|..|. ||..  | |.  .||...|..  ...||.. 
fldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1276-1360 3.3e-12 40.3 In-house 194-277 (515) alignment 
Range on Protein: 1276-1360
Range on HMM: 194-277/515.0
ILLVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.| .| |. .... . . ....|||  | |  .....   . . ||  ..|||....  | ..|  ||| .||  |...|| .| 
llklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0049772 (Phosphotyrosine protein) phosphatases II 1276-1365 3.1e-09 32.5 In-house 199-286 (314) alignment 
Range on Protein: 1276-1365
Range on HMM: 199-286/314.0
ILLVIEEMYRTqrkRGNTSIVVHCSDTVSRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVQQYQGIFQIVLTYLDSFETY
.. ..| . .    . .. ..|||.. ..|.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. ....
fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_PTPN3_pd Subfamily PTPN3 1276-1356 4.6e-08 27.3 In-house 193-272 (280) alignment 
Range on Protein: 1276-1356
Range on HMM: 193-272/280.0
ILLVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
.| ..|.. |..|.  .. .|||||  . |. .. .  |.. .  ..  . . ....  | |.   |||..||. . . .|
flefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0044763 (Phosphotyrosine protein) phosphatases II 1276-1355 1.4e-07 26.8 In-house 95-167 (178) alignment 
Range on Protein: 1276-1355
Range on HMM: 95-167/178.0
ILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVQQYQGIFQIV
.| ..| . . . .. .  ..||||  |.||....||   .      |. .......  | ..|  |..  |.. . .. 
flefvefieeal.dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1277-1360 1.8e-12 41.8 In-house 196-278 (315) alignment 
Range on Protein: 1277-1360
Range on HMM: 196-278/315.0
LLVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
| .| |. ...... . |..||||  | |. .....   ... | . ..|||...|  | ..|  ||| ..|  |...|| .| 
lklikev.kadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0046846 (Phosphotyrosine protein) phosphatases II 1278-1360 1.9e-10 36.3 In-house 96-174 (176) alignment 
Range on Protein: 1278-1360
Range on HMM: 96-174/176.0
LVIEEMYRTQRKRGnTSIVVHCSDTVSRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTVQQYQGIFQIVLTYLD
| . |. |...|.|   ..||||  ..|.....||      ...|  ..|...|.  | |.| |.||| .||. . . .| .|.
lellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellllk
0051082 (Phosphotyrosine protein) phosphatases II 1278-1353 1.8e-08 29.6 In-house 78-147 (151) alignment 
Range on Protein: 1278-1353
Range on HMM: 78-147/151.0
LVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
  . |. .  .. .|  ..||||  ..|.....|.   . .      ......|.  |.. ||.||. ||.. ...
davleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
0051429 (Phosphotyrosine protein) phosphatases II 1279-1362 1.5e-11 40.0 In-house 143-228 (272) alignment 
Range on Protein: 1279-1362
Range on HMM: 143-228/272.0
VIEEMYRtqrkrgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.||| .||. .....| .|.|.
llellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0041856 (Phosphotyrosine protein) phosphatases II 1279-1358 2.8e-10 35.6 In-house 101-170 (182) alignment 
Range on Protein: 1279-1358
Range on HMM: 101-170/182.0
VIEEMYRtqrkrGNTSIVVHCSDTVSRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 |||...      .  ..||||  |.|.....||   . .    | .......|  | ..||.|.| .||. . ...| .
fieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1280-1357 1.9e-20 67.9 In-house 187-264 (283) alignment 
Range on Protein: 1280-1357
Range on HMM: 187-264/283.0
IEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
.. .   |..  .. |||||| .. |.|.|.||...... .|| |.|||.|.|  | |... ||| .||. . ..|| 
fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1280-1361 3.5e-12 41.1 In-house 210-290 (325) alignment 
Range on Protein: 1280-1361
Range on HMM: 210-290/325.0
IEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
..|  ...  .. | |.||||. | |. .| .  . ..|  .|  .|.|...|  | ..|  |.|| ||  |.. .  .. |
vservtan.tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1280-1361 9.5e-10 32.4 In-house 306-387 (392) alignment 
Range on Protein: 1280-1361
Range on HMM: 306-387/392.0
IEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
|  .  .  .. . ||.|||     |. .||.|   | .      .|.|| .|  | ..  .||| ..|  .....  || .
iravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylht
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1282-1358 3e-09 31.2 In-house 219-294 (297) alignment 
Range on Protein: 1282-1358
Range on HMM: 219-294/297.0
EMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
| .|..  | |. ..||||  | || .   . . ..| . . . ||  .|.  | |..  |||..|.. ....||  
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1282-1362 4.9e-06 20.4 In-house 207-286 (290) alignment 
Range on Protein: 1282-1362
Range on HMM: 207-286/290.0
EMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
 . |. ||  .  .|||||  . |.  | |  ... .. ..|  .|. .. .. |  . .|||   ||  . .|.| .  .|
rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_PTPRN_pd Subfamily PTPRN 1283-1355 1e-06 22.7 In-house 216-288 (297) alignment 
Range on Protein: 1283-1355
Range on HMM: 216-288/297.0
MYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
. .. | |  ..||||||| . |. ....    .|.  |    ||.   |.  | |.|| |.| .|.. ... |
vnksyrGr.scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1283-1358 3.7e-06 20.8 In-house 192-268 (281) alignment 
Range on Protein: 1283-1358
Range on HMM: 192-268/281.0
MYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVQQYQGIFQIVLTY
. |  | |  |  |.|||  | ||  . |   ...  ..   . |. |..   |.  .  ||||.|||  |....| .
ilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1284-1357 3.2e-15 50.9 In-house 184-257 (267) alignment 
Range on Protein: 1284-1357
Range on HMM: 184-257/267.0
YRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 . | . ||  .||.||| | ||  |  . . ... ||||| |.|. |.  | |..| |.| ..|  | ...  
aknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPRG_pd Subfamily PTPRG 1284-1364 1.5e-12 41.5 In-house 210-292 (563) alignment 
Range on Protein: 1284-1364
Range on HMM: 210-292/563.0
YRTQRKRG--NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
 . .. .      ||||||  |.|. ....  | ... ..| ...||..||  | |..  |||  ||. .....|  . | ||
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1284-1359 3.4e-06 19.9 In-house 234-309 (346) alignment 
Range on Protein: 1284-1359
Range on HMM: 234-309/346.0
YRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
. ....  |. . |       |.  |  |  .||.       ......|. . |.||.|..  || .|. ||. |.
flsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_CG7180_pd Subfamily CG7180 1285-1359 1.7e-13 44.9 In-house 211-290 (296) alignment 
Range on Protein: 1285-1359
Range on HMM: 211-290/296.0
RTQRKR-----GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|. |..      .  .||..|| .||| ...|.  .... . |. .|||. .|  |...|. |..|..|. |....| ..
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_CG42327_pd Subfamily CG42327 1286-1358 2.2e-07 24.9 In-house 241-314 (319) alignment 
Range on Protein: 1286-1358
Range on HMM: 241-314/319.0
TQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
. ..  .  .|||||| | |. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1287-1359 9.2e-07 22.6 In-house 213-285 (302) alignment 
Range on Protein: 1287-1359
Range on HMM: 213-285/302.0
QRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.   .. ..|.     . | ..| ..|....| ...    . ...|| | |.| .|....||  .. ..|.|.
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_PTPN9_pd Subfamily PTPN9 1288-1359 4.7e-11 37.3 In-house 219-290 (297) alignment 
Range on Protein: 1288-1359
Range on HMM: 219-290/297.0
RKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 .  .  ||||||  . |.  |..   .... ...|..||....|  | |.  |.|| .||.  .. || | 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1289-1357 2.1e-12 41.6 In-house 209-277 (315) alignment 
Range on Protein: 1289-1357
Range on HMM: 209-277/315.0
KRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
.   ..||||||. | |.  |..  . ... ..| .|||.....  | .. . ||...||| |....| 
tnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN14_pd Subfamily PTPN14 1289-1360 1.9e-09 32.0 In-house 226-297 (300) alignment 
Range on Protein: 1289-1360
Range on HMM: 226-297/300.0
KRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
|  .  ..||||. | |. .   .   |.  ... .||. .||.  | |.   |||. ||. .......||.
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1290-1363 1.4e-13 45.5 In-house 210-285 (288) alignment 
Range on Protein: 1290-1363
Range on HMM: 210-285/288.0
RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL--DSFE
     |.||||. | |.  | |. . |.. ..| .|||. ...  | |..  |||..||. |....|.    |. .
adtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgva
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1290-1356 2.2e-07 25.3 In-house 171-237 (239) alignment 
Range on Protein: 1290-1356
Range on HMM: 171-237/239.0
RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 |    |.|||  | |.  |    . . ..| .  .|.|. .|. | ..|  ||| .||  |.  ||
pgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1290-1356 2.5e-07 25.1 In-house 172-238 (239) alignment 
Range on Protein: 1290-1356
Range on HMM: 172-238/239.0
RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 |    |.|||  | |.  |    . . ..| .  .|.|. .|. | ..|  ||| .||  |.  ||
pgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1290-1356 7.4e-06 20.3 In-house 189-256 (290) alignment 
Range on Protein: 1290-1356
Range on HMM: 189-256/290.0
RGNTSIVVHCSDTVSRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
  .| ..||| | .||||.. |      |   |.| . . .|||. | |.   ... ...  .   ..
asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1291-1360 2.4e-06 21.6 In-house 209-278 (287) alignment 
Range on Protein: 1291-1360
Range on HMM: 209-278/287.0
GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.   .|||..  . || .. |  . ... .  | .|| .|.   | .. . ||.| |.. ... . ||  
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1291-1366 3e-06 21.5 In-house 208-286 (307) alignment 
Range on Protein: 1291-1366
Range on HMM: 208-286/307.0
GNTSIVVHCSDTVSRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL-DSF-ETYS
 .  .|||||  | ||    | .   .|  . .   |. ....  | |.. ..||  ||  . ...| |. . . ||| 
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1292-1356 2.3e-06 22.0 In-house 172-236 (237) alignment 
Range on Protein: 1292-1356
Range on HMM: 172-236/237.0
NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 .  ..|||  | |...|    . . ..| . |.|... ..|   ..|  .|| .||  |.| .|
sgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1293-1352 7.1e-06 19.7 In-house 222-281 (302) alignment 
Range on Protein: 1293-1352
Range on HMM: 222-281/302.0
TSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
....||||  | |.  . |    |. |... | |. ....  |  . |.||. ||   ..
knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_PTPN1_pd Subfamily PTPN1 1294-1354 4.5e-06 20.6 In-house 203-266 (290) alignment 
Range on Protein: 1294-1354
Range on HMM: 203-266/290.0
SIVVHCSDTVSRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
  |.|||  . ||  || . | .    | .    .|. .||   | .. | .|| .| .  .. 
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla