Gene PTPRD-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP073_AA protein Get Run
AqueP073_AA_365-647 phosphatase_domain Get Run
AqueP073_AA_660-927 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
dsrm Double-stranded RNA binding motif 5-70 2.6e-12 33.7 Pfam-A 1-67 (67) alignment
Range on Protein: 5-70
Range on HMM: 1-67/67.0
PISKLQEITQSWKLAIPSY--RESDGTY--QLFGCEVTInlEGETIAfSALGRNKKESKAKAAEKALEYI
|.|||||. |  .  .. .   |  ..   . | ..|..  .|.... .. |..|||.. .||||||...
pkskLqelcqkkgkppnyeyvseegpphslkkFtvtvkv..ngklyg.tGvgssKKeAeqlAAekALqkL

HTH_31 Helix-turn-helix domain 109-160 1.2e-10 28.0 Pfam-A 2-54 (64) alignment
Range on Protein: 109-160
Range on HMM: 2-54/64.0
MGRLIQQSRSKAKLSQKDLAARINEKSQVISDYEQGKA-IPNAGVLKKMERAL
 |..... |  |.|||...|.|..     .|..|||.  .| ..|| .. |||
LGarLralReraGLsqeevAeragvSastlsriEqGrrgrpslavlaalaral

HTH_19 Helix-turn-helix domain 110-156 1.4e-08 21.3 Pfam-A 1-47 (64) alignment
Range on Protein: 110-156
Range on HMM: 1-47/64.0
GRLIQQSRSKAKLSQKDLAARINEKSQVISDYEQGKAIPNAGVLKKM
|. . . |.. .|.|..|| ... . . ||..| ||. | |. |||.
GerLkelRealgltqeelaeklgisrssiskiEnGkrdpsadklkki

HTH_3 Helix-turn-helix 116-160 7.1e-13 34.8 Pfam-A 4-48 (55) alignment
Range on Protein: 116-160
Range on HMM: 4-48/55.0
SRSKAKLSQKDLAARINEKSQVISDYEQGKAIPNAGVLKKMERAL
 | ...|||..||.... . . ||..| |...|.  .|||...||
lRkqlglsqeeLAeklGvsrstisriEnGernPsletlkklakaL

Shisa Wnt and FGF inhibitory regulator 273-313 5.7e-06 15.5 Pfam-A 77-115 (179) alignment
Range on Protein: 273-313
Range on HMM: 77-115/179.0
VFGIAGGGalVVAVLIIIIICVIVICCCLIRRQRESPSSPL
 . .. .   .. |..|. . ||..|.....   . .. | 
kvvlivsi..ilivvfivvliviftcskcvlekavrrqrpv

0045450 (Phosphotyrosine protein) phosphatases II 358-646 2e-91 302.2 In-house 4-304 (307) alignment
Range on Protein: 358-646
Range on HMM: 4-304/307.0
NTHPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPG---HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQ-EGSDYINASFL--------DGF
.... |  ...  .....  ...... .|| ...       .. ..|....|  |||| .||||||||||||... . |.|||||||.         ||.
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

MKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHF
 .....||||||. ||. .||||.|||.. .|||.|.| |.  .||. |||.. .|  ||| . |||..   |..|| ||...   . ..  |.|..||.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TAWPDHGVPEFPTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDN--VDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
|.|||||||... ..|..|. ||.....| |. ||..|||||||||||||.... ||... ...    ||..  | |||.||  .||...|| |..||. 
tgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

EAI
| .
ell

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 358-642 2.9e-42 139.4 In-house 6-285 (305) alignment
Range on Protein: 358-642
Range on HMM: 6-285/305.0
NTHPTIHNYQFPA-HLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwqeGSDYINASFLDGFMKPQ-QYIATQ
.||| ....   |  . | .. .. | .  .    |     .     . . .||||...   |.. |||.       |||| | ..   | |. ..|..|
qthpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaq

GPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTY-GGVEVTLVE-CVPLANYTFRTFTIMKGGTSKD-LREVRQFHFTAWPDHG
||. .|| ||| || ...   |||. |  |   .||  |||.   |. .  .|. |  |  . |.   .    |...   | |    ||....| ||| |
gpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrg

VPEFPTSMLSMIRCVRAHHnrLppdtgPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
||    . | .. ..|  .  .     |..||||||.||||| | |. .|..|    .   .   |  ||.|| | .|.. ||.|||  .
vppckltslellsairgsk..v.....pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm

subfamily_PTPRD_pd Subfamily PTPRD 359-928 7e-269 888.2 In-house 1-564 (564) alignment
Range on Protein: 359-928
Range on HMM: 1-564/564.0
THPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPM
....|.......|.| ...|....|.||. .| ... ...|.||...| |||||.||..|||.||.||.|...||||||||||.||..|...|||||||.
sskpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

AETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNeRCTYGGVEVTLVECVPLANYTFRTFTImKGGTSKDLREVRQFHFTAWPDHGVPEFPT
|||| .||||||||||.||||.|||.||..|||..|||.. . ..|||...|||.|.. ||.|..|||.. |  .|.. |||||||||.||||||||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesat

SMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQF
|.|..||.|||...   ||.||..|||||||||||||.|||.||.|| . |..||||..|..||.|||.|||||.||.||||||.||.|||.|.|.|...
slLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl

PVHLDKLELIQEDGESSLLEMEFQRLA-TDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNT
  ||.||. ..|| |.. ||.|||||| ....|...||.|||..||.||||.||...|..||.||.|||.|.||||||||...||..||..|||.|.|||
kqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplknt

VEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQM
|||||||.||...||||||||||||..|.|..|.||||....|||||...||||..|.|.|..|....|..||.|.||..|........|..|.|.||..
vedfwrmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkekseavyllhtvqavdkklltvidsvldllka

IQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQK
...|.|.....|..|..||...|||...........||...|||....|.|.||.|.|..||..||.|..|
vrkvleravvvrvsegvtvtgasgvlfatlervklevlldvsvearllltqrvkllsildsarlqtelilk

0039614 (Phosphotyrosine protein) phosphatases II 359-650 7.2e-91 300.0 In-house 10-293 (297) alignment
Range on Protein: 359-650
Range on HMM: 10-293/297.0
THPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHpKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQ-EGSDYINASFLDGFMK-PQQYIATQG
....|.   ....| ....|.......|| ... ..   ...|. ..|  |||| .||||||.||||.... . ..|||||||..||. . ....|||||
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PMAETIGEFWRMVWEQNSATIVMVTKLQEKSTvKCDCYWPTDVNercTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkdlREVRQFHFTAWPDHGVPEF
|. ||.. ||||||||.. .|||.||| |..  ||. |||....   |||.. |||...  |..|| ||... ..| |   |.|..|..| |||||||. 
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhgvpps

PTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGV
....|.... || ....| |. ||..|||||||||||||.... ||... ..  .||..  |  ||.||. .|||..|| |...|. | . ...
lellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 359-681 1.3e-84 278.9 In-house 2-314 (315) alignment
Range on Protein: 359-681
Range on HMM: 2-314/315.0
THPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPM
.|  |   |. ...|  . . .. | ... .||    || .||.   |  |||| ||..||..||.|  .. ...|||.||.|.||. |...|||.||| 
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

AETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvneRCTYGGVEVTLVECVPLANYTFRTFTIMKGgtsKDLREVRQFHFTAWPDHGVPEFPT
......|||.|.|.. ..|||.|.| |.   |.. ||| .   . .|| . ||...     .|| ||.... |   ...||| |.|.|.||| |||.. .
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfg...dnirevvqlhytswpdmgvpkyti

SMLSMIRCVRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQF
... .|| |. ||.    . |...|||||||||||||. .|..|.. .. |. .|.|  .| .|..|  |||. .|| ||..|. |.. || | .. | .
plmnlirtvkqhhtn...svgaivvhcsaGvGrtGtfitldavldq.aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdly

PVHLDKLELIQEDGESSLLEMEF
  . | |     |  |.||. .|
lqrydsllapspdtgstllqeqf

subfamily_PTPRK_pd Subfamily PTPRK 360-682 4e-94 310.0 In-house 1-313 (314) alignment
Range on Protein: 360-682
Range on HMM: 1-313/314.0
HPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNpghpKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMA
||.|.      ..|... ...  | ||. ...       ..|. . | .|||. .||.||..||.| |.. .  ||||||...|.. .|...|.||||. 
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNErctYGGVEVTLVECVPLANYTFRTFTIMK-GGTSKDLREVRQFHFTAWPDHGVPEFPT
||. .|||.|...|.|.|||.|.|.|.. |||  ||| | .    || ..|.|||. .||..  |.|.. |   . .. ||||||.|..||||.||   |
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat

SMLSMIRCVRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQF
..|...| | ....    . |...|||||| ||||||..||..|. | . |. ||..  |  ||...  ||.||.|| ||...| ||  || | .   .|
gllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmi.eregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef

PVHLDKLELIQEDGESSLLEMEFQ
     .   .. . .|| |. |||
kalylesirldpqtnssqlkeefq

subfamily_PTPRB_pd Subfamily PTPRB 362-646 1.1e-103 341.3 In-house 6-285 (293) alignment
Range on Protein: 362-646
Range on HMM: 6-285/293.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIP-MNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
 |.  .| .|.. |. ... ||.||. ..  ..  . ...|. ..| ||||| |||||||.||||...| ..|||||||....|.  |...||||||. |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNErCTYGGVEVTLVECVPLANYTFRTFTIMKggtSKDLREVRQFHFTAWPDHGVPEFPTSM
|. .|||||||..| .|||.|.| ||  |||. |||.| .. ..|| ..||||.   | ... |...| |   .|. |.|||.|||.|||||||| ....
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep.vlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktl

LSMIRCVRAHHNRlPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
|...| || ....   ...|..|||||||||||||. .| .||.| . || |||.| |. ||..||..||||.|| |||... . .
ldfvrtvreaiek.taskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldll

0051299 (Phosphotyrosine protein) phosphatases II 362-646 4.2e-98 323.6 In-house 4-286 (288) alignment
Range on Protein: 362-646
Range on HMM: 4-286/288.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPK-EVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
 |.  ..  ..  ...|.. ...||| ... .  ...  .|....|| |||| .||||||.|||||... .|||||||||..||. .....||||||. .
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGG---TSKDLREVRQFHFTAWPDHGVPEFP
|...|||||||||. .|||.|||.|.. .||. |||.  ..  ||| . |||.... |..|| ||... . .    ..  |.|..||.|.|||||||. |
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
...|...| || ...   .. ||..|||||||||||||...| .|......   ||... |  ||.||..||||..|| |..||. |..
ellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Ptp69D_pd Subfamily Ptp69D 362-665 2.9e-87 287.6 In-house 3-305 (307) alignment
Range on Protein: 362-665
Range on HMM: 3-305/307.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
.|.  . .  | . . . .. ...|. ... .   .  .|.. . |. ||||..| ..|.|||||.... .| ||||||||. |. . ...|| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMKGG----TSKDLREVRQFHFTAWPDHGVPEF
|||.||||..||.. .|||...|.||.  ||. ||| .  . . || . |.||.     .|. |.. . | .      .| |.| |.|.|.|.|  ||| 
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PTSMLSMIRCVRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSD
....| .|. || ...      .|..|||||||||.|.|| .||.||.. . ||.|||.  |  ||.|||..||  .|| |.. |. . .  | ||.. |
argllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd

QFPVHLDKL
..  ....|
dledaierl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 362-456 2.2e-22 73.1 In-house 4-95 (95) alignment
Range on Protein: 362-456
Range on HMM: 4-95/95.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwqeGSDYINASFLDGFMKPQQYIATQG
 ||   | .|.  |  | .| | .|| .|.|  | |  |   |.|. |||. ||.||| ||| |.| .    |||||| |.||. . . |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 363-673 4.2e-67 221.2 In-house 4-262 (392) alignment
Range on Protein: 363-673
Range on HMM: 4-262/392.0
IHNYQFPAHLAVMRmnDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETI
|   |||| .   |   .  |.|||  .|  . .|. ||. | || ||||.|||||| .||||  .     |||.|||....|   . |||.||| | ..
ipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

GEFWRMVWEQNSATIVMVTKLQEKStvkcdcywptdvnerctyggvevtlvecvplanytfrtftimkggTSKDLREVRQFHFTAWPDHGVPEFPTSMLS
 .|||||...| .||.|||||.|                                                 .| | | ||||| |||..||.. .|.| 
ddfwrmvfqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllk

MIRCVRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHL
.|. |.|.. .    | |.|.||||||||||  . |||.. .  .    ||..  || .|..| .||||..|| ||. |. | .    | .   .|  ||
fikevkadfGqy...thpliihcsagvgrtgvvisidsvvahakk.trmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhl

DKLELIqEDGE
..|.    ||.
qdlsts.sdGd

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 365-653 5.3e-93 306.5 In-house 11-297 (298) alignment
Range on Protein: 365-653
Range on HMM: 11-297/298.0
NYQFPAHLAVMRMNDNQRFMEEFGTIPMNPG----HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
. ...   ||.. ..  .. .|| ..         . ||||... |  |||| .|...|..|| |.... .| |||||||||... . . .||||.|. |
kaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNErcTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSM
|. .|||||.|....||||.|.|.|. ..|.  |||.. .|  ||| ..|.| .    |... |.... |  .. . |||||.||| |||.||||  ||.
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsv

LSMIRCVRAhhNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDV
| ..| |||  ..      |.||.|||||||.|||..|||.|.|. . |  ||..  |  ||..|  .||||.|| ||.||. ||.... ...
ldllrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0043336 (Phosphotyrosine protein) phosphatases II 365-644 1.8e-89 295.2 In-house 4-275 (278) alignment
Range on Protein: 365-644
Range on HMM: 4-275/278.0
NYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGE
  ... .|. . .|.......|| ... ..  ....|....|  |||| .||||||.||||| ..  ..|||||||..||. .|...||||||. ||.. 
vkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPtdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMI
|||||||... ||||.|.| |.. |||. |||   ..  |||.. |||...  |..|| ||... . |...  |.|...|...|||||||| ....|...
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldfl

RCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
. || . .   .. ||..|||||||||||||.... .|... ..  .||..  |  ||.||  .|||..|| |..||. |
kavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 365-682 2.4e-82 271.3 In-house 5-313 (315) alignment
Range on Protein: 365-682
Range on HMM: 5-313/315.0
NYQFPAHLAVMRmnDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGE
  |||| .   |      | |||  .|  . ... ||  . |  ||||.||||.|..||||  .  .  |||||||.. .. . . |||.|||   .. .
vaqfpafvnknr..htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvdd

FWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFtIMKggTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMI
|||||.... .|||||||.||   .||  |||    .   .| ..|.|..  . .. . | . ...   |.. | | ||.|| |||.||..  .|.| .|
fwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtr..kseesrtvtqfqftewPdkGvdkqtssllkli

RCVRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDK
. |.| ...   .. ...||||||||||| .. ||.....| . .. ||..  |. ||..| ..||||..| ||..|. | .    | ..  .|  ||. 
kevkadngk...kefsllvhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LELIQEDGESSLLEMEFQ
|    .    | .  ||.
lhtsvdgsgrskmtkefe

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 366-684 2.1e-112 370.3 In-house 5-318 (318) alignment
Range on Protein: 366-684
Range on HMM: 5-318/318.0
YQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKE-VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGE
 ..  |.. .|.. .  . ||.  .  .. .. .  .. ..| ||||| |||.||||||||.... .||||||||...||... ..|||.|.|..||| .
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMI
|||||||||||.|||.|...|.. .|.. ||| .  .  .|| . |.| | | |..|. |.|.. .   ... |.|||.|.|.|||.|||| ..|.|...
fWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlv

RCVRAHHnrLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDK
| |.. .  .....||..|||||||||||.|...|..|.|| . |  ||... |. ||.||| |||||||| ||.... ||.|.| |.| ....  .. .
rqvskaq..qksgagpivvhCsaGvGrtGvfiavdilleri.kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LELIQEDGESSLLEMEFQRL
|.  . .   . ...|||||
lreqdpesgttemdaefqrl

subfamily_PTPRG_pd Subfamily PTPRG 366-658 5.5e-97 320.3 In-house 4-299 (563) alignment
Range on Protein: 366-658
Range on HMM: 4-299/563.0
YQFPAHLAVMRMNDNQRFMEEFGTIP--MNP-GHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGS-DYINASFLDGFMKPQQYIATQGPMAET
 .|  |.| .  .....| |||  .   ...   . | .. ..|  |||| ||..||..||||| .  .... |||||...||. | ...||||||...|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

IGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMK----GGTS-KDLREVRQFHFTAWPDHGVPEF
.  ||||.||||.|.|||.|.|.|.   ||| |||.  .|  ||| ..|||.|   || || ||..| .     . . .. ..|||.|.| ||||||||.
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

PTSMLSMIRCVrahHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSD
..  |....         . ..||..||||||||||||..|.|..|..| . |. |...| .  .| ||||.||||.|| |.|.|. |||| . |.....
slpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae

QF
| 
qv

0040438 (Phosphotyrosine protein) phosphatases II 367-683 6.3e-98 323.2 In-house 4-313 (317) alignment
Range on Protein: 367-683
Range on HMM: 4-313/317.0
QFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
... .|  . ..|.....||| ... .. .. .||....|  |||| .||||||.||||| ..  ..|||||||. ||. .....||||||. .|.. ||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
||||||.. .|||.|.| |.. .||. |||.  .|  |||.. |||.... ||..| ||... . |.| . |.|..||.|.|||||||. |...|.... 
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgds.esrtvthfhytgWpdhgvppspdllldflea

VRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLE
||.. .   .. ||..|||||||||||||.... ||... ... .||..  |  ||.||. .|||..|| |...|..| . ...|..   .....|.|| 
vreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkll

LIQEDGESSLLEMEFQR
 .   ....| |.|...
iplalddvklkekelkl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 367-666 1.2e-90 298.7 In-house 8-303 (305) alignment
Range on Protein: 367-666
Range on HMM: 8-303/305.0
QFPAHLAVMRMNDNQRFMEEFGTIPMNpGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
.. |..  .|..... . ... ..... ... .| . | | ||||. .| ..|. |..|.. . .. |||||||..||. . ..||..|||. .|. .||
dlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfW

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
|...|    ||||.|||.|    ||  |||. ..|.  .| ..|.| .    ..|. | ..| .  ..|. | | |...| |||||||.|.||.||.|. 
rliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr

VRAHHNRlppDTG-PMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
|. ....   | | |..|||||||||||.|...| .|.| |. |. ||... .  ||..|  |||| ||| |.|.|..| | || |..  . . ....||
vqkdqkk...dkgvpllVhCsagvgRtGvfiavdialer.lkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

E
.
k

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 367-686 2.3e-84 278.4 In-house 6-316 (515) alignment
Range on Protein: 367-686
Range on HMM: 6-316/515.0
QFPAHlaVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
||||   | . .    | |||  .|    .|. ||. | |  |||| |||||| .||||  .. .  |||.|||.. .|   . |||.|||   .. .||
qfPaf..vnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfW

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgtsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
|.|...| .||.|||||.|   .||  |||    .   .| ..| ||     .. . |..|..||   .| | | ||||| |||.|||.  .|.| .|. 
rlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg...ddsrtvtqfhfteWPdkGvpkhtssllklike

VRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLE
|.| |...   | |.|.|||||||||| .. |||.. ..  . . ||..  || .|..| ..|||..|| ||..|. | .    | .   .|  ||. | 
vkadhgqy...thpliihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh

LIQEDGESSLLEMEFQRLAT
   .    | .  ||| | .
ssgdgrgrskmtkefqtlks

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 367-657 2.4e-73 241.9 In-house 14-295 (297) alignment
Range on Protein: 367-657
Range on HMM: 14-295/297.0
QFPAHlaVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKpqQYIATQGPMAETIGEFW
.|..   | .  . . | |||  .|    .|. ||.   |. |.|| ||||||  ||||  |  .  |||.||||. |. .  ..|.|| || .|. .||
dfatl..vqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfW

RMVWEQNSATIVMVTKLQEKSTvKCDCYWPTDVneRCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPE--FPTSMLSMI
.||.... .||||.....|.   ||  ||. .     |.| | |.|        .  |.... ||  .|  | |.|..|. |||. |..    .|.| .|
amvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkg.kakarrvvkqyqfveWPdkaverkdsassllkli

RCVRAHHNRLppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQ
  || ...      ||..|||.||||||| .. |||.. .. . |..|||.| |. ||..| ..|||..|| |...|..||. .  |.. .. 
sevrkdfsqn..aegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 367-659 8.6e-67 220.5 In-house 6-292 (439) alignment
Range on Protein: 367-659
Range on HMM: 6-292/439.0
QFPAHLAVMRMNDNQRFMEEFGTIPM-NPG--HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIG
.|  |.  .  |... | |.| .|   .|       .|  | . .|||| .. ..||||| |  .     | |||| ...|. ... |||||||  ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

EFWRMVWEQNSATIVMVTKLQEKSTvkcdcYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIM-KGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLS
.|||.|.|....||||.|.| |        |||.|  . . || . |     . | ||. | | .. .  |..  | | |||..||||. ||   . .| 
dfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

MIRCVRAHHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFP
..|.. .  ..   ..||..|||||||||||| . .|  |.. |. |..||| | |..||.||. |||.  || ||..|. | |  | . || |.| 
flrainsandk..eeygpvvvhcsagvGrtGtiialdialeq.lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 367-646 9.3e-64 210.1 In-house 6-283 (290) alignment
Range on Protein: 367-646
Range on HMM: 6-283/290.0
QFPAHLAVMRMNDNQRFMEEFGTIPM-NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEG--SDYINASFLDGFMKPQQYIATQGPMAETIG
.|  ..|  ... |..| ..|...   .  |  .|.. . |  .||..||..||  |. |  .  ..    .||||....|. . .||||||||. .|. 
kfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

EFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERctYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHG-VPEFPTSMLS
.||...|..... |||.|. .|. .|||  |||.  ...  || ....|..   | .|. |.. . .  .... ..| |...|.|...| |..  |..|.
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

MIRCVRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
. . .. .. |     ....||||..|||...|....  ...  . |  .|..  .  .| |.  .|||..|| .|.. . ...
ieemyktqrkrg...ntsivvHCSdtvgrsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 368-646 5.7e-89 293.0 In-house 9-279 (288) alignment
Range on Protein: 368-646
Range on HMM: 9-279/288.0
FpAHLAVMRMNDNQRFMEEFGTI-PMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
  |. | .  .... | ||. .. ...  . .....   |  |||| ||||||..||||  .. ..|.||||||..||  | ..|||||||.|.|...||
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkdlREVRQFHFTAWPDHGVPEFPTSMLSMIRC
..|.|... ||||.|.| |.   ||. |||.. ..   || |.|||||   | ... |.. . | .|    .|. |....|||||||||  . .| ..| 
elvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllekkkte...leitqyqylaWpdhgvPeskapllellrq

VRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
|   ..    ||||.||||||||||||||...| ..... . || .|. | |. ||.||...|||. || ||.|.. . |
vkvanqa...dtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 370-682 1.5e-95 315.0 In-house 12-319 (319) alignment
Range on Protein: 370-682
Range on HMM: 12-319/319.0
AHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMV
 .|  .. . .. . .|| .. .      . |. | |  |||| |||.||.|||.||... .||||||||||.||. . ...||||.|...|| .|||||
erlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

WEQNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA
||..| ..||.|||.||  ||.  |||.   .  .|| . ||| |   |..|  | ... |  .  . ||| .|..|.||||.|||  ||.| ... .| 
Weeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

HHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLELIQ
 ...  .. ||..|||||||||||||.|.| ||.|. . |  .|..  |  || |||.|||...|| ||.||. ||. .| |..  ...   | .|.  .
srek..tqsgPivvhCsaGvGRtGtfivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekv

EDGESSLLEMEFQ
 |   . || |||
adtgetglerefq

0050432 (Phosphotyrosine protein) phosphatases II 371-651 1.8e-98 325.0 In-house 32-304 (308) alignment
Range on Protein: 371-651
Range on HMM: 32-304/308.0
HLAVMRMNDNQRFMEEFGTIPMNPGHPK-EVANYECNLAKNRYDNILPYDHTRVKLstvkwQEGSDYINASFLDGF--MKPQQYIATQGPMAETIGEFWR
. ......|.....||| ...... ... .||. ..|  |||| .||||||.||||     .|||||||||. ||.   .|...||||||. .|.. |||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVN-ERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
||||||. .|||.|||.|.. .||. |||.... .  .||.. |||...  |..|| ||..... |.. . |.|..||.|.|||||||. |...|.... 
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflel

VRAHHnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
|| ..     . ||..|||||||||||||...| .|... ..  .||... |  || ||..||||..||.|...|. | . . .|
vrksl.....pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 371-646 2.5e-83 274.4 In-house 5-276 (281) alignment
Range on Protein: 371-646
Range on HMM: 5-276/281.0
HLAVMRMNDNQRFMEEFGTIPM-NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMV
||. .. |||. |.||. ..   . ... . .. . |  |||| ||  ||.||||..  . .. .|||||.|..|. ....|||||||. ... .||.||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEQNSATIVMVTKLQEKSTVKCDCYWPtDVNERCTYGGVEVTLVECVPLANYTFRTFTImkGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA
|||.  .|||||.  |.. .||  ||| | |.. .|| | |. ..    |.|  |.|..    .| . |||.|...|||||||||. .. .|.  . |. 
weqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlk

HHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
 ...      |...|||||||||||.. .| ..... . . ..|.   |. ||..||.||||  || |.. |. .|.
ltek..ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 371-666 7.6e-79 260.2 In-house 13-308 (325) alignment
Range on Protein: 371-666
Range on HMM: 13-308/325.0
HLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMV-
|.   . .|.. |  ||| .| . |  |.||    | ||||. |....|..|| | | | .  |||||||.|  ..| . ..|.| |...||...||.| 
hvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvl

-WEqnSATIVMVTKLqEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTImKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVR
 |.  .. .|.. .| ..   .|  ||| .. .  |.||.|| |.    ...|  | . . |.    . | |.||.. .|.| ||...|....|... | 
dWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

AHHNRLPP---DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
| ..|.      ..|..|||||||||||.|. . |.|..... | .|||.| |  ||..|  ||.| ||| .|.||. ||. .| |||    |  .|  |
avservtantkastpilvhcsaGvGrtGvfislysalakvie.esrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklssl

E
.
q

subfamily_PTPRA_pd Subfamily PTPRA 373-679 7.5e-98 322.4 In-house 24-328 (330) alignment
Range on Protein: 373-679
Range on HMM: 24-328/330.0
AVMRMNDNQRFMEEFGTIPM-NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWE
 .   .||..| ||| ..|  .     |.|. | |  |||. ||||||..|| ||... .| ||||||||.||. . ...||.||| .||. .||||.||
rirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiwe

QNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMK---GGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVR
|.||||||.|.|.|.   ||  |||..     ||| . |.. ... | .|| | | . .   .   |. | |||||||.||| |||  |  ||.... |.
qksativmltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

AHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLELI
. ...    .||..|||||||||||||.|.|..|.|. . |  ||... |  ||.||  ||||. || ||.... |    | |..    .  ||.||   
klnqq...sagpivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk

QEDGESSLLEM
  . .   || 
itgtdkiglee

0036941 (Phosphotyrosine protein) phosphatases II 374-656 3.9e-94 310.6 In-house 6-287 (297) alignment
Range on Protein: 374-656
Range on HMM: 6-287/297.0
VMRMNDNQRFMEEFGTIPMNPG-HPKEVANYECNLAKNRYDNILPYDHTRVKLstvkWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQ
............|| ... .    ...||....|| |||| .|||||||||||     .|||||||||..||.  ....||||||. .|...||||||||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

NSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVP--LANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAH
|. .|||.|.| |.  .||. |||....|  |||.. |||...    |..|| ||... . |.. . |.|..||.| |||||||| |.|.|..|. || .
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkv

HNRLPPDtGPMIVHCSAGVGRTGTFVVIDSMLQRILH--GEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSD
.. ||.. ||..|||||||||.|||...| |||.. .   | .|||.  |  ||.||...|||..|| |..||. | . .. |..  .
lkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll

0047943 (Phosphotyrosine protein) phosphatases II 374-646 3.6e-92 304.0 In-house 5-272 (273) alignment
Range on Protein: 374-646
Range on HMM: 5-272/273.0
VMRMNDNQRFMEEFGTIPMNPG-HPKEVANYECNLAKNRYDNILPYDHTRVKLstvkWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQ
...........||| ... ..  ....||....|. |||| .||||||.||||     ..||||||||..||. .....||||||. .|...||||||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NSATIVMVTKLQEKSTVKCDCYWPTDVNE-RCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKdLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHH
|. .|||.|.|.|.. .||. |||....|   ||| . |||...   ..|| ||... . ||..  |.|..||.| |||||||. ..|.|..|. || ..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

NRLPPDtGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
. || . ||..|||||||||||||...| .|... ..  .||..  | |||.||  ||||..|| |..||. | .
ealpsn.gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 374-444 1.5e-09 31.9 In-house 6-76 (244) alignment
Range on Protein: 374-444
Range on HMM: 6-76/244.0
VMRMNDNQRFMEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwQEGSDYINASFLDG
| |..|..   |||  .  .     .  |   .| .|||| ||||.|.||| ||. | .||||||||....|
vsrlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqg

subfamily_PTPN14_pd Subfamily PTPN14 375-643 5.9e-59 194.5 In-house 18-293 (300) alignment
Range on Protein: 375-643
Range on HMM: 18-293/300.0
MRMNDNQRFMeEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQeGSDYINASFLDGFM--KPQQYIATQGPMAETIGEFWRMVWE
..... . |. |.  || .      ..|. . |  |||. ..|||...||.||. | .  ..||||| .   .  | ..||..|||.  |. .||.||||
kkleegkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

QNSATIVMVTKLQEKSTVKCDCYWPTD--VNERCTYGGVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLS---MIRC
|. . |||.|. .|.   |.  |.| .   ... ..|  .||         .. .....     ||. |.|  . .| |||||||| ....||   ... 
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

VRAHHNRLPP---DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
|| . |.  .      |..|||||||||||  .. | ... . |.| ..||   .. ||.|| ..|||  || |..... 
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvli

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 376-654 1.6e-54 179.7 In-house 4-274 (283) alignment
Range on Protein: 376-654
Range on HMM: 4-274/283.0
RMNDNQRFMEEFGTIPMnPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWqegsDYINASFLD---GFMKPQQYIATQGPMAETIGEFWRMVWEQ
| |.|. |.| .  . . |  . ..|  . |  |||...|.|.|  ||.| .       |||||.|.       . ..||..|.|. .|. .||.||...
rvnnnklfrevlkrlsv.pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

NSATIVMVTKLQEKSTVKCDCYWPTDVNErcTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFptsMLSMIRCVRAHHN
. ..|||.|||||   .||  ||| .  |   ||   ||| . .    .. . ... . ...|.   .  . .  | . |       . |...  .   .
kitaivmltklqedlrikCsqyWPkrGse..dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqai...inslvkfnkvisl

RLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILhGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVT
.     ||..||||.|.|||..|. . . .. .|  |  ||..  |. .|.||  .||| ||| ..||.. |   || |...
qteskkgPivvhCstgiGrtavfiaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 378-653 5.9e-65 214.1 In-house 17-285 (287) alignment
Range on Protein: 378-653
Range on HMM: 17-285/287.0
NDNQRFMEEFGTIPMNPGHPKEVAN--YECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSA
. |. |.. | ..     ...||     . |  |||. .||..|  || |     .|  |||||.|.||. . ...|....||..|. .||......|  
kgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvt

TIVMVTKLQEKSTVKCDCYWPTDVNerCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHG-VPEFPTSMLSMIRCVRAHHNRl
.|||.....|. . .|  |||.. .   ..|  ...|..    |.|. |.. . . . ..| ..|.|...|.|...| |.|. |..| . . ..... | 
aivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr.

ppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDV
    ....||||..|||...|. ..  ...  . |  .|..  .   | |.  .||| .|| || ... | . .. | .
..gntsivvhCsdtvGrsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 378-649 1.3e-50 166.8 In-house 12-296 (301) alignment
Range on Protein: 378-649
Range on HMM: 12-296/301.0
NDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKW--QEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSA
. ...| |.. ..  .  .. .|   | | | ||. || .||. |. |.. .   .   .|||||..||. . ...||.|||| .|. .|||..|..  .
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIM--KGG------------TSKDLREVRQFHFTAWPDHGVPEFPTSML
.|||||.|.|..  ||  |||.  .|. ..| ..||||.   . ... | ....  .|             ..|. ..| |.. | ||..||   |  .|
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

SMIRCVRahHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACG
  |  |   | .  .. ||..||||..|.|.|... ..  |      |  ||... .  .| ..  .|.| .|| .|...|.. ... 
qviddvi..hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 379-665 7e-87 286.7 In-house 32-310 (319) alignment
Range on Protein: 379-665
Range on HMM: 32-310/319.0
DNQRFMEEFGTIPMN--PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSAT
| ...  ||  ..    ..  .. || . |  |||. |||..|...|||  .  .|.||||||||..|. ....|||.|||. .|. .||||.||.|..|
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMVTklqeksTVKCDCYWPTDVNERCTYGGVEVTLVECVplANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLpP
||..|        ||  ||| .....   . |.|..||    |.|. | . . . |  || |...||||  |||.|||..|. .. ... ||  ...   
ivllt......kdkcsqywplkivikeerfkvkvdsveet..aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.n

DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
.  ...|||||||||||...|.| .|.|. . |. ||.|  |  ||.||| .||   ||.||. |. |    | .||.  .||..|..|
hranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel

subfamily_PTPN13_pd Subfamily PTPN13 379-645 2.3e-73 241.8 In-house 9-268 (273) alignment
Range on Protein: 379-645
Range on HMM: 9-268/273.0
DNQRFMEEFGTI-PMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSdYINASFLDGFMKP--QQYIATQGPMAETIGEFWRMVWEQNSA
|.|   ||| ..  . |    ||.. . | .|||| |.||||.|||||.    .||. |||||..   .     .|||.|||. ||. .||.|||||.. 
dqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

TIVMVTKLQEKSTVKCDCYWPTDVNERCTYGG-VEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrl
 |.|||. .||  |||. |||   |.. .  . .||.|.. . | ... |.... .   |.. ||| ...|..|||||||  ....| ... ||  ..  
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd.sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..

ppDTGPMIVHCSAGVGRTGTFVVIDSMLQrILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
  |.||..||||||.||.||...|| .|. ... . ..|.   |  ||.||. .|||.||| |...|| |.
..dagPivvhcsaGiGrsGtlitidvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_PTPN6_pd Subfamily PTPN6 380-646 5e-84 276.9 In-house 25-297 (306) alignment
Range on Protein: 380-646
Range on HMM: 25-297/306.0
NQRFMEEFGTI---PMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLStVKWQEGSDYINASFLDGFMK--PQQYIATQGPMAETIGEFWRMVWEQNS
.. |.||| ..    ..  . .. ..   |  |||| ||||.|||||.|.  .   |||||||..... .|   ..|||||| . .|. .||||||..||
kagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

ATIVMVTKLQEKSTVKCDCYWPTDVNERCtYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRL
  |||.||  |..  ||  |||.  ...  || ..|| |.   ||.|..|.... |  ..|. |||.|.||..|||||||. |  .|.... |......|
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

P-PDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHG--EDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
   ..||..||||||.||||||.||| .|. | .   . ..||.  | ..|.||. .||||.|| |...||.. |
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 380-445 9.2e-12 39.0 In-house 21-86 (440) alignment
Range on Protein: 380-445
Range on HMM: 21-86/440.0
NQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGF
 . | .|.  .|    .| ..|.   |  |||| ||| |||.|| |  ||    |||||||...| 
srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 381-644 4.6e-75 247.2 In-house 5-266 (274) alignment
Range on Protein: 381-644
Range on HMM: 5-266/274.0
QRFMEEFGTIPMNPgHPKEvANYECNLAKNRYDNILPYDHTRVKLSTVKW-QEGSDYINASFLDGFM-KPQQYIATQGPMAETIGEFWRMVWEQNSATIV
. . .||  .|.|  ...|  .   .  |||| .||| ...|| |.. .  .| |.|||| .. |.  . . |.|||||...|. .||||......  ||
kdlekeflelPlnf.dqee.ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTKLQEKSTVKCDCYWPTDVNE--RCTYGGVEVTLVECVPLANYTFRTFTIMKGGTskdLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPP
|.|||.|.   ||  |.|.. .     .||.||.. .. |   .|. |.... .       |.|  . .|.|||| .|. ....|.... |.  ...   
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeena

DTGPMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
 ..|..||||||.|||| |. |.  ... |. |  ||. . |. || .|  ||||..|| .||.|. .
klapvvvhCsaGiGrtGcfiaisiavrq.lreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 381-642 2.8e-48 159.5 In-house 16-273 (307) alignment
Range on Protein: 381-642
Range on HMM: 16-273/307.0
QRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVkwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMV
|....||  .     .   |  ...|  ||||...   |..|. . .      |||| | .|   .||...|..|||. .|. .|| |. ...  ...|.
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLV----ECVPLA-NYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhhnrlp
 |. | . .||. ||| .  .. ..|    |.      .  || .  .   | .|   ... | .... .. |||.|||.   . . ..  ||       
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......

pDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
 || |..|||||||||.|| | |  . .... |..  |.   |  ||.||.. .||| ||...|  .
.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 381-642 3.3e-47 155.5 In-house 31-279 (290) alignment
Range on Protein: 381-642
Range on HMM: 31-279/290.0
QRFMEEFgtIPMNPGHPKEVANYECNL--AKNRYDNILPYDHTRVKLSTVkwqEGSDYINASFLDGFMKpqQYIATQGPMAETIGEFWRMVWEQNSATIV
. ..|.    |  |... |   .. |    |||| ..   | ||| |.        ||. | ...|      .| |||....|. ..|||| ... |.||
keylekl..kpylpvqylerkifdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaiv

MVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVE-CVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrlppd
|. .| |.   ||. |.|    |  |.| . |.  |   . ||   .|.....  . |.   .. ..  .|||. |.    ..| ..| .|         
mlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtlrilrka.......

TGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
.||..||||||.||||||| |.  || .|.|  ..|. . |  ||| |   || . ||. . |..
sGpvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveil

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 382-642 7.1e-38 124.9 In-house 12-265 (281) alignment
Range on Protein: 382-642
Range on HMM: 12-265/281.0
RFMEEFGTIPMNPGH-PKEVANYECNLAKNRYDNILPYDHTRVKLST-VKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVM
 | .||  .| .|      | |   |  |||| ||   | .||.|   .  .. .||| | ..   .  . || ||||  ||  .||||.|..|...|||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

VTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVplANYTFRTfTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrlppdTG
. .. |    ||  |.| .      .  . |.  .     | .. | | ..     . | . .. .  |||  |||    || ..| .||.       . 
lcqfletnrekcaeyfprnahcclqfdklsvsyedst..vnkslvt.trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.......st

PMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRN-QRNFMVQTEDQYFFIHEAI
| ..||||||||.||.. ..  || |       ||   |. ||   |   ||| .||..| . .
ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 382-647 2.8e-18 60.4 In-house 27-286 (302) alignment
Range on Protein: 382-647
Range on HMM: 27-286/302.0
RFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTvkwqEGSDYINASFLDGFMKPQQYIATQGPMAETI---GEFWRMVWEQNSATIV
.  .|| .|     .  .   .  ||.||. ...  .|...|||..    |  .|.||| ..     .. | .| |  ..     ||||||.... ...|
evkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MVTKLQEKSTvKCDCYWPTDVNERCTYGGVEVTL--VECVPLANYTFrTFTIMKGGTSK-DLREVRqfHFTAWPDHGVPEFPTSMLSMIRCVraHHNRLP
.. . .| ..   . ..|.  ..  .|| . |    || .  ... . .  ..  | |   | .|   ..| |... ||.  ...   .  |  ...  .
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektry.viEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakv..fakkik

PDTgPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
 |  ....    |.|| |.|..    .... .| ... |   |. .|.||  .|.. .|| ... |..  | 
ade.ntvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyik

0046845 (Phosphotyrosine protein) phosphatases II 383-651 1.4e-96 318.5 In-house 2-279 (284) alignment
Range on Protein: 383-651
Range on HMM: 2-279/284.0
FMEEFGTIPMNPGH---PKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQ-EGSDYINASFLDGF-----MKPQQYIATQGPMAETIGEFWRMVWEQN
..||| .....  .   . .||....|| |||| .||||||.||||.... . |.|||||||..||.     ......||||||. .|...|||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATIVMVTKLQEKSTVKCDCYWPTDvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNR
. .|||.|.| |.. .||. |||.. .|  |||.. |||...    .|| ||... . |...  |.|..||.|.|||||||. |...|...| || ....
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

lPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGED--NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
  |. ||..|||||||||||||...| .|... ....  .||... |  ||.||..||||..|| |..||. |.. ...|
.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

DSPc_SM00195 384-646 3.1e-88 290.9 In-house 3-262 (263) alignment
Range on Protein: 384-646
Range on HMM: 3-262/263.0
MEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTK
 ||| .. .. . .... |. . | .|||| ||||||||||||.. . .||||||||....|  |...|||||||. .|. .|||||||... .|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLA-NYTFRTFTIMKGGTsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppdTGPM
 .|.   ||| ||| . ..  |.| ..|.|||.     ... ||... | |. .. |.|.|.....|||||||. ..|.|...| |. ....    .||.
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGVGRTGTFVVIDSMLQRILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
.||||||||||||||.||..|... .... |||   |. ||.||  ||||..|| ||.||| |.|
vVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 384-646 3.1e-88 290.9 In-house 3-262 (263) alignment
Range on Protein: 384-646
Range on HMM: 3-262/263.0
MEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTK
 ||| .. .. . .... |. . | .|||| ||||||||||||.. . .||||||||....|  |...|||||||. .|. .|||||||... .|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLA-NYTFRTFTIMKGGTsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppdTGPM
 .|.   ||| ||| . ..  |.| ..|.|||.     ... ||... | |. .. |.|.|.....|||||||. ..|.|...| |. ....    .||.
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGVGRTGTFVVIDSMLQRILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
.||||||||||||||.||..|... .... |||   |. ||.||  ||||..|| ||.||| |.|
vVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_CG42327_pd Subfamily CG42327 384-569 8.2e-30 98.5 In-house 8-192 (319) alignment
Range on Protein: 384-569
Range on HMM: 8-192/319.0
MEEFGTIPMNPGHPKEVANyECNlAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMK-PQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTK
.|||  .|    .  ||    ..  |.|. |..|  .||| |  .  .. . |..||.. |. . | .|||.| .. ..  .|||.||||.| .|| .|.
aeefrdlPqliaradevPv.tsk.dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LQEKSTVKCDCYWPTDV--NERCTYGGVEVTLVECVPLANYTFRTFTImKGGTSKDLREVRQFHFtAWPDHGVPEFPTSMLSMIRCVRA
|.|.   .|  |.||    ... .|| . ||| .     .|   |. . |    .  ||.  . .  |.. .||  ......|.  ||.
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.krvdkeesrelthywy.kwleaevPaeeaaliamllevrs

0045098 (Phosphotyrosine protein) phosphatases II 386-648 3.6e-85 281.0 In-house 13-274 (278) alignment
Range on Protein: 386-648
Range on HMM: 13-274/278.0
EFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKlstvkwqegsDYINASFLDGFmkPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQE
 .  .....    ..|.|..||.|||| .||||||.|||          ||||||..||.  |...||||||. .|.  ||||.||... .|||.|.|.|
fefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelve

KSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKG---GTSKDLREVRQFHFTAWPDHGVPEFP--TSMLSMIRCVRAHHN--------
.. .||. |||   ..  |||...|||...  | .|| ||...       ..   |.|...|.. |||||||..|  .|.|.... .|....        
lgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

--RLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlhgEDNVDIYGHVTLLRNQRNF-MVQTEDQYFFIHEAINEAIAC
  .| .. ||..||||||||||||.|... ||...   |..||..  |. ||.||.. .||...|| |..|.. | . .
slllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 390-645 1e-68 226.3 In-house 4-263 (270) alignment
Range on Protein: 390-645
Range on HMM: 4-263/270.0
IPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFM-KPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKST
.. .  ..... ..  . . ||| .|||  .|||.|.... .. . |||| .. ||  ....|||..||.. |. .||||.||... .|||.|.|.|| .
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

VKCDCYWPTDVNE--RCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLRevrQFHFTAWPDHGVPEFPT------SMLSMIRCVRAHHNRLPPDTgP
 ||..|||....|  ....| ..|. .. .    | ..  .. . |... |     |....|||||||. .       ..|.|.| ||.....|   . |
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv...HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.P

MIVHCSAGVGRTGTFVVIDSMLqRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
..||||||||||||....| .. |.|. . .||.   .. ||..|  .||. .|| |...|. | 
llvHcsaGvgRtGtlialDiav.rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

0049772 (Phosphotyrosine protein) phosphatases II 391-646 1.6e-45 151.5 In-house 31-280 (314) alignment
Range on Protein: 391-646
Range on HMM: 31-280/314.0
PMNPGHPKEVANYECNLAKNRYDNILPYDhTRVKLSTVKWQeGSDYINASFLDGFmkpQQYIATQGPMAETIGEF----------WRMV--WEQNSATIV
 . | .   ||....|  |||| .|||.| .||.|...  . ||||||||..|||   ...||||||. .|.  |          ||||  ...|. .||
svlpeltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------VTKLQEKStvkcDCYWPTDVNERCtyggvevtlvecvplanY-------TfrtftimkggtskdLREVRQFHFTAWPD
|                      ..| ..     . ... |. . .                                         |.. ... . .||
msrdevladelsrLdaAlgKtpllildgng....neptaadlellk.................eelydpelf..............erlgikylripvpD

HGVPeFPTSMLSMIRCVRAHhnrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlhGEDNVDIYGHVTLLRNqRN---FMVQTEDQYFFIHEAINEAI
...|  .  ...... ....     .. || .|||.||.||||||||.. .. .   | .  ... .| | |   |    .... .|| ||.||..|..
gsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll..gvsleealedvrlkRp.inpnpgfieqleqyefilealleyl

subfamily_PTPN3_pd Subfamily PTPN3 393-645 5.1e-69 227.3 In-house 28-274 (280) alignment
Range on Protein: 393-645
Range on HMM: 28-274/280.0
NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwqeGsDYINASFLD----GFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKST
.||   ..|.   ||.|||| .|||||.|||||.  .     |||||....    .    ..|||||||.|.|  .||.|||||.| .|||.| | |.  
kpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

VKCDCYWPTdVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlppDTGPMIVHCSAG
|||  |||.  .....||. .|.. ..    .| .| .....  ..|. |.. |. ..||||||||. ....|.... ||. ..    .. |..||||||
vkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdk.etkeerkilqlqylaWpdhgvPddsadflefvervrklrsg...keePvvvhCsaG

VGRTGTFVVIDSMLQrILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
.|||| .....  |. ..  ...| .   |  .|.||  .|||..|| |. ||| ..
igrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 395-647 2.7e-37 123.4 In-house 32-272 (288) alignment
Range on Protein: 395-647
Range on HMM: 32-272/288.0
GHPKEVANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCY
.  . . ..  | ...||.|.   | ||||||     .   ||.|  .     ... | .| |.  ||.|.|.|. |..   |||...| ||   | . |
asidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaey

WPTDVNERCTYGGVeVTLVECVPLANYTFRTFTIMKGGTSKDLRE-VRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlppdtgPMIVHCSAGVGRTG
.|. . |.  .| .  | |           . ....     . .  |.. |.  |.|.||||   | | ..  ......       |..||.||||||||
fPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.......PivvhssaGvGrtg

TFVVIDSMLQrILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
|...|  .|.  |  .|.. |   .. ||..|   .||| || ..|  . | ..
tlililiale.slrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 396-665 1.9e-85 281.8 In-house 15-274 (284) alignment
Range on Protein: 396-665
Range on HMM: 15-274/284.0
HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTklqeksTVKCDCYW
  .. || . |  |||. .||..|...|||  .  .|.||||||||. |. ....|||||||. .|. .||||.||.|..|||..|        ||  ||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PTDVNERCTYGGVEVTLVECVplANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTF
| .....   . |.|..||    ..|. | . . . |  || |..|||||  |||.|||..|. .. ... ||  ...   .  ...|||||||||||..
plkivikeerfkvkvdsvees..eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcsagvgrtgvy

VVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
.|.| .|.|. . |. ||.|  |  ||.||| .||   ||.||. |. |    | .||.  .||..|..|
ivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel

subfamily_PTPN12_pd Subfamily PTPN12 396-647 2.9e-82 270.8 In-house 30-278 (290) alignment
Range on Protein: 396-647
Range on HMM: 30-278/290.0
HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
...|... | | .|||| .|||||..||.||. . .||||||||.|. |  ....|||.|||...|. .||||.||.|   .||. .. |    ||..||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PTDVNERCTYGGVEVTLVECVPLA-NYTFRTFTIMKGgtsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGT
|  ..|....| .|||| |   .  ... ||... .    |. |.|.|||.|||||||||. ..|.|..|. || ...    .  |..||||||||||||
peegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGt

FVVIDSMLQRILHGED--NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
 ..|| . . . ..    ..|..  |. ||.||. .|||..|| ....|. | . 
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPN1_pd Subfamily PTPN1 396-650 4.5e-68 224.1 In-house 22-275 (290) alignment
Range on Protein: 396-650
Range on HMM: 22-275/290.0
HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWqegsDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
.| ..|. . | ..||| .. ||||.|.||   .     ||||||...     ..|| ||||...|.. ||.|||||.| ..||. |. ||...||  ||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PTDVNER-CTYG--GVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhNRLPPDTGPMIVHCSAGVGRT
|.. .|.  ..    ..|.|..     .|| |.. . .  .... ||. .||.|.||| |||| |...|...  ||     | .| || ..|||||.||.
Pqgeeekellledtklkvkliseerksyytvrllelen.lktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGpavihcsaGiGrs

GTFVVIDSMLQRILHGED--NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGV
|||...|..| .| . .|  .|||  ..  ||..|  ..|| ||  | . || | . .  
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik

0040439 (Phosphotyrosine protein) phosphatases II 397-646 3e-83 274.5 In-house 2-246 (249) alignment
Range on Protein: 397-646
Range on HMM: 2-246/249.0
PKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWP
...||....|. |||| .||||||.||||| ..  ..|||||||..||.  ....||||||. ||.. ||||.||... .|||.|.|.|.  .||. |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTFV
.  ..  .||.. |||...  ...|| ||... .    .. |.|.....| |||||||... ..|..|. || ....| |. ||..|||||||||||||.
l..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

VIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
... ||... .   .||..  | |||.||. .||...|| |..||. | .
aaylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPRN_pd Subfamily PTPRN 397-646 3.7e-62 204.7 In-house 47-292 (297) alignment
Range on Protein: 397-646
Range on HMM: 47-292/297.0
PKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFL-DGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
 ||||. | |. |||. ..|||||.||||..   .| |||||||.. |   .   |||||||.|.|. .||.||||| .. ||..|.|.|... .|. ||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PTDVNErcTYGGVEVTLV-ECVPLANYTFRTFTImKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlppDTGPMIVHCSAGVGRTGT
| . .|  .|.  || || | .   .|  |.| . |   ... | | |||| .||..|||  . |.| . | |   .      . |..||||.|.||||.
pdeGse..vyhiyevhlvsehiwcddylvrsfyl.knlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG...rscpivvhcsdGaGrtGv

FVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
...|| .|.|.|.|  ..||   .  ||.||. .|.|.||. |.  |. | .
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 397-491 5.5e-12 39.8 In-house 25-118 (332) alignment
Range on Protein: 397-491
Range on HMM: 25-118/332.0
PKEVANYECNLAKNRYDNILPYDHTRVKLSTvkwQEG-SDYINASFLDGFMKPQQYIATQGPMAE-TIGEFWRMVWEQNSATIVMVTKLQEKSTVKC
|.   ..  |.  ||   .  .||.||.|.    |.|  |. |||..||. |   || .| |. . |   ||||| |.. . |...  ..||   |.
pntydkflnnmdmnriphlycfdhsrvelap...qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_PTPN9_pd Subfamily PTPN9 398-644 4.6e-79 260.5 In-house 34-288 (297) alignment
Range on Protein: 398-644
Range on HMM: 34-288/297.0
KEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPT
 ....  .|| |||| ..| ||.|||.|..|. .| ||||||.|.||. ... .||||||. .|. .||||||||.  .|||.|.. |.  .||  |||.
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

DVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAH----------HNRLPPDTGPMIVHCSA
. ...  .| ..|. || .   .|..|...| .  . .. |.|  | |..|||.|||.  .|.| ... || .          ... .|.  |..|||||
eeessaefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
|.||||||. .|  |.| |. ...||.   | |||.|| |..||..|| | . |. |
GiGrtGtfitldiclsr.leevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPN23_pd Subfamily PTPN23 398-644 1.5e-65 215.9 In-house 35-278 (288) alignment
Range on Protein: 398-644
Range on HMM: 35-278/288.0
KEVANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMK-PQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWP
. .|  ...  |||. .||||||.||||     ..  |||||||. .      ..||||.|...|...||.||.|| | .|||... .|.   |.| |||
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

TDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA-HHNRLPPDTGPMIVHCSAGVGRTGTF
.| .|  ..| ..||| .   . ..  |....   ...   ..|.  ..|.||..|||. | ..| ..  |.. ....  .   |..|||||||||||.|
edkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

VVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
 .. . .. . .|.  .||   |  ||.|| ||||...|. |  ||. |
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 399-652 4.4e-84 276.6 In-house 2-247 (250) alignment
Range on Protein: 399-652
Range on HMM: 2-247/250.0
EVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVkCDCYWPTD
.||.   |. |||| .|...|..|| | ..| .. |||||||||.|... . .||||||. .|| .|||||.|..|.||||.|.|.|.  . .  |||..
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

VNErcTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppDTGPMIVHCSAGVGRTGTFVVI
. |  .||.| |.| .    |.|| |.. . |  . .| | |||.||..||| ||||  |..| ... |.| ...   ...|.||.|||||||.|.|..|
kae..kyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa..gnaPvivqCsaGvgrsGafiai

DSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACgVTD
|..|.| |. |  ||..  .  ||..|  .|....|| |..|.| .|. . | |
davler.lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds.ved

0042113 (Phosphotyrosine protein) phosphatases II 399-644 1.6e-80 265.4 In-house 2-241 (245) alignment
Range on Protein: 399-644
Range on HMM: 2-241/245.0
EVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTd
.||....|  |||| .|||||||||||| ......|||||||. ||.  ....||||||..||.. ||||.||... ||||.|.. |.. |||. |||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

vNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlpPDTGPMIVHCSAGVGRTGTFVVI
 .|  |||.. |||...  |..|| ||... .   ..  |||...|.. |||||||. . ..|.... || . ..  .. ||..|||||||||||||...
.gesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaa

DSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
. ||... .   .|...  |  ||.||  .|||..|| |..||. |
ylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 400-644 3.7e-80 264.2 In-house 4-240 (243) alignment
Range on Protein: 400-644
Range on HMM: 4-240/243.0
VANYECNLAKNRYDNILPYDHTRVKLstvkwqEGSDYINASFLDGFmkPqQYIATQGPMAETIGE----FWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
.|....|| |||| .||||||.||||      ||||||||.. ...  | ..||||||. ||. .    ||||.||... .|||.|.|.|.. .||. ||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PtdvNERcTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNR-----LPPDTGPMIVHCSAGVG
|   .|  |||...|||...  |..|| ||....  ....  |.|...|...|||||||. |...|.... ||.. ..       .. ||..||||||||
p...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFVVIDSMLQRIlhgedNVDIYGHVTLLRNQRNF-MVQTEDQYFFIHEAINE
||||..... ||...     .||..  | |||.||.. .|||..|| |..||. |
RtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 400-643 1.7e-64 212.3 In-house 2-238 (239) alignment
Range on Protein: 400-643
Range on HMM: 2-238/239.0
VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGF-MKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTD
 |.   | ||||| ||. |||.|| |  .  .  |||||||.|  .   |. |||||| .. . |.||||.|..  . |||.| | |    ||  |||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

VNERCtygGVEVTLVECVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahHNRLpPDTGPMIVHCSAGVGRTGTFVVI
 .. |    . ||| .   .|.|  ||| . . | ... | | |.||| |||.|||.. |..| . | .   .. | | . | ..||||||||||.|.||
tskyc...nlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl.pgarpwvihcsagvgrtgaflvi

DSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
|.||..  . .  |||. .|  .|..| .|||| .|| ||| |. 
damlrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 400-487 5.1e-11 35.8 In-house 21-81 (169) alignment
Range on Protein: 400-487
Range on HMM: 21-81/169.0
VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINAsfldgfmkpqqyiatqgpmaetigefwRMVWEQNSATIVMVTKLQEKS
.|.  || .|||    |   ||||||  |  . |||||||                           ||.|| |.. ||..   ..| 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 400-487 6.1e-11 35.4 In-house 20-80 (169) alignment
Range on Protein: 400-487
Range on HMM: 20-80/169.0
VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINAsfldgfmkpqqyiatqgpmaetigefwRMVWEQNSATIVMVTKLQEKS
.|.  || .|||    |   ||||||  |  . |||||||                           ||.|| |.. ||..   ..| 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn

subfamily_ptpA1_pd Subfamily ptpA1 401-608 1.6e-48 160.5 In-house 42-259 (418) alignment
Range on Protein: 401-608
Range on HMM: 42-259/418.0
ANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFmKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVN
 . . | .|||| |||| .||||.|  .. .|||||||| ..||   |.|.|.||||. .|| .|||||||.    |||...  |.  .||| ||| .. 
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

---------ERCTYGGVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPPDT---GPMIVHCSAG
             .|   | ||| .   .    |  |       . |.. |...  |||| .|..   .  ... .  ..|.. | .    |.|||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirl.tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGTFVVIDSMLQRILHG
|||||||.    |.... | 
vgrtgtfctavimmkkldhy

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 401-654 9.8e-37 121.4 In-house 30-279 (285) alignment
Range on Protein: 401-654
Range on HMM: 30-279/285.0
ANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMKPQ-QYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDV
. ||.|   ||| ..   . ||| |     .   ||| ||..    | |  ||.||||. ||. .||.|..... | ..|.  | |    ||  |.|  .
tayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

NERCTYGGVEVTLVECVP--LANYTFRTFTIMKG--GTSKDLrEVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahhnRLPPDTGPMIVHCSAGVGRTGTF
 |   .|  |.|| ||    .|   . ..|...    .|. |  . . .   |||.  ||    |. . . |.    .. |   |. |||||||||| ||
gevvkfgkyeitlteckeeaiagtilnaltvintedassepl.ymnhvqvpwwpdqlapedarpmielykwvk....kvnpkekpicvhcsagvgrtatf

VVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA-IACGVTDVT
| ||    ||.  . |...   |  .|  |   ||.  |..|..  . |  |  || . |
vgidyatirime.npniemldivremramrfqavqshmqflflyvvlmeyfigegvvert

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 401-483 1.1e-09 32.3 In-house 32-119 (347) alignment
Range on Protein: 401-483
Range on HMM: 32-119/347.0
ANYECNLAKNRYDNILPYDHTRVKLSTVKWQEG-----SDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKL
...| .|.|||  .    | ||| ||  | . .       ||||| .      ..|| || |. .|. .||.||   . . .| . . 
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 402-642 2.3e-46 153.0 In-house 29-291 (297) alignment
Range on Protein: 402-642
Range on HMM: 29-291/297.0
NYECNLAKNRYDNILPYDHTRVKLSTVKwqEGSDYINASFLD--GFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDV
. .  | |||| .|| .| |||||  |    ..||||| ..      .. .|| .|||. .|. .||..|.||.  .||||.||||    ||  |||  |
krnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

NERCTYGGVEVTLVECVPLAnYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVP-------EF----------PTSMLSMIR--------CVRAHHNRL
.|| . | | |  .  .    .    .| ..    .. | ||   | .|||||||        |             ||...          . . .   
qerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

pPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
 |   ...|||||||||.|  |  | .|... . .   |.   .. ||.||  .||| .|. ....|.
.prnayllvhcsaGvGrsGvvvlsdvilaklrk.kripdvaailsilreqrarlvqtleqfellydav

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 402-654 3.4e-32 106.3 In-house 48-297 (310) alignment
Range on Protein: 402-654
Range on HMM: 48-297/310.0
NYECNLAKNRYDNILPYDHTRVKLSTVKWQEgSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdVNE
 |. .. |||| ...  | .||||   | .   ||| | ..      . .| .|||.  || .||||.... . .|... |  |.   ||  |||. .  
aykkymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgv

RCTYGGVEVTLV-E---CVPLAN--YTFRTFTIMKGGTSKDLREVR--QFHFTAWPDHGVPEFPTSMLSMIRCVRAHHnrlppdtGPMIVHCSAGVGRTG
  ||| . || . |      . |   ||    .       .|.|.|    ..  ||| |||.     .      .  |       || .||||||..|..
tetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdrly

TFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEaINEAIACGVTDVT
. | ..  .... .| ..||.   .| |...|   .||| || .|.  .  ..| | |.|.
vvvalklkidkldrg.lkvdaeevktellksraiciqtelqyliidr.vriifargeteva

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 402-647 4.2e-18 60.0 In-house 43-280 (303) alignment
Range on Protein: 402-647
Range on HMM: 43-280/303.0
NYECNLAKNRYDNILPYDHTRVKLSTvkwqegSDYINASFLDgFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNE
..  |. |||. ...  ||..||||       | || ||.|. .   .. | || |.. |  .||.|. ||.   ....    |  ..  |  .| . . 
qfvknmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

-RCTYGGVEVTLVECVPLAN-YTFRTFTImKGGTSKDLREVrqFHFTAWPDHGVPEF-PTSMLSMIRCVRAHHNRLPPDTgPMIVHCSAGVGRTGTFVVI
 .     . |     | |.. ....  ..   |. | .  |   |. |||   .|      ..  |  ...   .  . | | .    .|.||.||| ..
lkfeersirvgefkrvelgdgwvlkvlsv.sngdyksflhv..hhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalf

DSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
..    .   .  .|.   .  .|| |   ||   |. ...  . | . 
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 403-645 1.1e-64 212.8 In-house 4-239 (239) alignment
Range on Protein: 403-645
Range on HMM: 4-239/239.0
YECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGF-MKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNE
   | ||||| ||. |||.|| |  .  .  |||||||.|  .   |. |||||| .. . |.||||.|..  . |||.| | |    ||  |||   ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

RCtygGVEVTLVECVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahHNRLpPDTGPMIVHCSAGVGRTGTFVVIDSM
 |    . ||| .   .|.|  ||| . . | ... | | |.||| |||.|||.. |..| . | .   .. | | . | ..||||||||||.|.|||.|
yc...nlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl.pgarpwvihcsagvgrtgaflvidam

LQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
|..  . .  |||. .|  .|..| .|||| .|| ||| |. ||
lrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_egg_pd Subfamily egg 403-643 2.2e-29 97.1 In-house 37-267 (307) alignment
Range on Protein: 403-643
Range on HMM: 37-267/307.0
YECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstVKCDCYWPTDVNER
 . || | |   .   | .||||   . |   |.| |  ..|     ..| .| |. .|  .|||||....   |||.|  .|    .|. |||   .. 
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

CTY--GGVEVTLVECVPLANYTFRTFTIMKGGTSkdlREVRqfHFTAWpdHGVPEFPTSMLSMIRCVRAHHNRlppdTGPMIVHCSAGVGRTGTFVVIDS
  .  |..... ..    |.  ||   .   |.    .| |  .   |   |  .. . . | .| .|   |     . |..|..  || ...|.| |. 
lvtvpGslrienlkvdskadplfrvtklklvGgd...deer..flehw..qgdvnnssdvysplrvlrklrnl....skpvvvqdilGvskaatlvaiei

MLQRILHGED-NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
 |  .| |      .   | .|| .|.. |..  .|.|..  . 
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 404-643 1.7e-57 189.4 In-house 36-274 (287) alignment
Range on Protein: 404-643
Range on HMM: 36-274/287.0
ECNLAKNRYDNILPYDHTRVKLSTvKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNERC
  .  |||| ..||.|.||| ||. . . ||||||| .. .. . ...||.|||.| |...|||.|.|..||.....|.  |..  ||  |||   .   
laavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

TYGGVEVTLVECVPL-ANYTFRTFTIMKGGTsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAH--HNRLPPDTGPMIVHCSAGVGRTGTFVVIDS
  ||  |.|..   .  .|. |.. ...  | .. | |.|... .|||....    ... ..  |. |   .|   ..||..||...|.||.|... .  
rvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

MLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
...| .    .||.   |  ||..|. .||.  |. .. ||. 
lvsrled.lGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_eak_pd Subfamily eak 405-645 2.4e-26 86.9 In-house 51-304 (332) alignment
Range on Protein: 405-645
Range on HMM: 51-304/332.0
CNLAKNrYDNILPYDHTRVKLSTVKwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCT
 .. .|   .|.|||.  |.|.. . ..   ||||| ..     ..|| |  .  . .  ||.|| ||.| .||.. .  |.   | | |.| .  |   
eavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGGVEVTLVECVPLANYTFRTFTIMKGGTSKdlrEVRQFHFTAWPDHGVPEFPT-----------SMLSM-------IRCVRAHHNRLPPDTGPmIVHCS
.| ..|.  | |  ... .| . . ||  ..   .|  ...  | .  .| .              .| .       .. .  ..   ||   | |. ..
fGildverkefvkrniletrllelskGneth...rvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap.iiqsa

AGVGRTGTFVVIDSMLQRILHGEDNV-DIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
 |  |.|.||||| ... |     |.  .   .   ...|.  | .. |. ||.|.. . 
rGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy

Y_phosphatase Protein-tyrosine phosphatase 406-643 3.3e-86 283.9 Pfam-A 1-234 (235) alignment
Range on Protein: 406-643
Range on HMM: 1-234/235.0
NLAKNRYDNILPYDHTRVKLstVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTY
|. |||| .|||||.|||||   . .. ||||||....|. .....||||||. .||..||||||.... .|||.|.|.||. .||. |||.. .| .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGVEVTLV--ECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHnrlPPDTGPMIVHCSAGVGRTGTFVVIDSMLQ
| ..|.|.  |.   ..||.|.... | ..... |||.|.|.|.|||||||| |.|.|..|| |. ..    ...||..||||||||||||||..| .|.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldille

RILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
.. ..|. ||..  |  ||.||. |||...|| |...|| 
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 406-643 3.3e-86 283.9 In-house 1-234 (235) alignment
Range on Protein: 406-643
Range on HMM: 1-234/235.0
NLAKNRYDNILPYDHTRVKLstVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTY
|. |||| .|||||.|||||   . .. ||||||....|. .....||||||. .||..||||||.... .|||.|.|.||. .||. |||.. .| .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGVEVTLV--ECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHnrlPPDTGPMIVHCSAGVGRTGTFVVIDSMLQ
| ..|.|.  |.   ..||.|.... | ..... |||.|.|.|.|||||||| |.|.|..|| |. ..    ...||..||||||||||||||..| .|.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldille

RILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
.. ..|. ||..  |  ||.||. |||...|| |...|| 
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 406-643 6.3e-68 223.5 In-house 3-236 (237) alignment
Range on Protein: 406-643
Range on HMM: 3-236/237.0
NLAKNRYDNILPYDHTRVKLSTVKwqEGSDYINASFLDGFM-KPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPtDVNERCT
| .|||| ||  |||.|| |       |||||||..|.||   |..|||.|||.  .  .||.|||... . |||.| | |.  .||  ||| . ..  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaa

YGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQR
|| . |.|     ...|| |.....| .| |..| . |..||.|||.|||.  ...| . . .   ...  ...|| |.|||||||||| |.|||.||..
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlrq

IlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
  . .  |||| .|  . ..| ...||.||| |||..| 
a.kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_CG7180_pd Subfamily CG7180 406-651 1.8e-65 215.5 In-house 42-295 (296) alignment
Range on Protein: 406-651
Range on HMM: 42-295/296.0
NLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTvKCDCYWPTDVneRCTY
|. |||. ...|||..|| |.... .| ||||||.. |.|.|...|| |..|. ||..||||.|..... ..|..||  . .  ..  ||| .   .  |
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqy

GGVEVTLVECVPLANYTFRTFTIMKG---------GTSKDLREVRQFHFTAWPD-HGVPEFPTSMLSMIRCVRAHHNRL--PPDTGPMIVHCSAGVGRTG
| ..| .||   .|| . ||| ..|          . . . | |..|..| |.  . ||   .... ..| ||   ..    |..||..|..| |..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
 .. ||  |. . . |..||... |  ||..|. .|.. ..| .| . ..||. |...
vylaidanlelv.ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd

0041856 (Phosphotyrosine protein) phosphatases II 406-651 3e-55 181.9 In-house 1-176 (182) alignment
Range on Protein: 406-651
Range on HMM: 1-176/182.0
NLAKNRYDNILPYDHTRvklstvkwqeGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTklqekstvkCDCYWPTDVnercty
|| |||| .||||||.|          ..|||||....| ......||||||. .|. .|.||..|..  |||..|         ...|||...      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

ggvevtlvecvplanytfrtftimkggtskdLREVRQFHFTAWPDHGVPEfPTSMLSMIRCVRAhhnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRi
                                |.. |.... |||||||. . ..|..|. |..       . || .||||||||||||.|... |... 
...............................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.

lhgedNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
     .|...  | |.|..|. ||.|..||||.. |. | . ...|
.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 406-644 6.1e-43 141.7 In-house 33-257 (267) alignment
Range on Protein: 406-644
Range on HMM: 33-257/267.0
NLAKNRYDNILPYDHTRVKLSTVKWQegsdYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstvKCDCYWPTDVNERCTY
| ..||.|. ||||.||| |.| . .    |||||...|. . ...|.||.|.  ||..|. .. .|. ..||..||  .    .   .||  . .   |
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakky

GGVEVTlvECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGvpeFPTSMLSMIRCVRAhHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRI
  . |    ..   .  ..  |.      .  ..|  ...  |            |  .  . | .|.|     |..|.||.||||.|||.||||.|.|.
qdltve..hslekeendyqiitlelkfknesahnvtlyyykkwnint...nnkpylkplfgila.knqlengnrPlvvacsdGvGrsGtflvidsqlera

lHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
   |. .||.  .  .|.||  .|.| ..| .||| . |
.ktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 407-642 4.7e-41 135.5 In-house 49-283 (305) alignment
Range on Protein: 407-642
Range on HMM: 49-283/305.0
LAKNRYDNILPYDHTRVKLsTVKWQegSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYG
  |||| ..   |. ||||    |    .|| | ..    .|...| || |. .|  .|| | ....  .| |. .|.|| . ||  |.... ..  .. 
agknrykdvgcldnnrvkl.egpwp..heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

GVE-VTLVECVPLANYTFRTF--------TIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahhnrlpPDTGPMIVHCSAGVGRTGTFVV
  .    | .   ... ||.          ..  |. .. | | ..|.  ||| |||   ...| ..   |       |  ||..||||||.||||. |.
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.......pskgpivvhcsagigrtgsvvm

IDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
.. .|...| |.   |    .  .|.|||  .||..||.|.|. |
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 407-497 2.3e-24 80.8 In-house 48-152 (350) alignment
Range on Protein: 407-497
Range on HMM: 48-152/350.0
LAKNRYDNILPYDHTRVKLS--------TVKWQEGSDYINASFLDGF-----MKPQQ-YIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCD
 ||||| |||||.|.||||           .  ...|||||..|        ..|.  |||||.|. .|. .|.... . .   |...|...|    ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

CYWPT
 ||. 
rYWqe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 407-497 5.1e-15 49.6 In-house 49-155 (349) alignment
Range on Protein: 407-497
Range on HMM: 49-155/349.0
LAKNRYDNILPYDHTRVKLST--------------VKWQEGSDYINASFLD--GFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVK
 ||||| .||||.|.||||                 .     ||||| .|    .   ..||||| |.  |. .|....  ..   .. ... .|.|  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CDCYWPT
|| ||  
cdiywqe

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 408-645 6.2e-30 99.0 In-house 45-275 (312) alignment
Range on Protein: 408-645
Range on HMM: 45-275/312.0
AKNRYDNILPYDHTRVKLSTvkwqEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPT-----DVNER
  ||| ||  .|  |  |.     .   || | |.    ||.....||||. .|.  ||...    |..|.... . | .. ||  |        |... 
dlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

CTYGGvEVTLVEC--VPLANYTFRTFTIMKGGTSKDLrEVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhhnrlppDTGPMIVHCSAGVGRTGTFVVIDS
  |    .| .|       . | | . ..   | ..   . .. ...|||||.|.   . | .. .|.        |  |.| |||||||||||...|.|
rvyte.ycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkk.......dkkpviahcsagvgrtgtlalies

MLQRILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
|.  . |     ..     |||..|   |..  || .   .. | 
miaalrhprk.qnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 409-638 1.3e-28 94.7 In-house 53-273 (301) alignment
Range on Protein: 409-638
Range on HMM: 53-273/301.0
KNRYDNILPYDHTRVKLSTvkwqEG-SDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGG
|.||...    .| |.. .    .|    | | ...   .|...||||||. .|  .|| |.   .  .|||...  || . ||. | |....|.   | 
khryptvPckPstaveviv....dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

VEVTLVECVP--LANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlppdtgPMIVHCSAGVGRTGTFVVIDsMLQRI
 ......       . . ||. .       . | |  . .. |.|.|||.  . .  ..  |.  ..       |..||||||.||. .|.  . .| | 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigte.ylare

LHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFI
.. . ....   .  ||..|   |||. | ...
veadptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 410-642 3.5e-22 73.9 In-house 23-255 (290) alignment
Range on Protein: 410-642
Range on HMM: 23-255/290.0
NRYDNILpYDHTRVKLSTVKWQEGSDYINASFLDgFMKPQQYIATQGPMAET-------IGEFWRMVWEQNSATIVMVTKLQEKSTV----KCDCYWPTD
.|... |   .||| |   . .  .||| |...  . . .. |.|| | ...       | .|| |. . ..  .||. . .|||.      |  | |. 
qRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

VNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTsKDLrEVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrlppdTGPMIVHCSAGVGRTGTFVVI
|.|  ...|..|   . .   .   |. ..  ..  ...  |    .  | .  |.| . ..||.|. |.|.       . |.||||  |. |  ..  |
vgeelkfkgltvkCkskekeddvetRelvvkfdde.eef.tvtHsllkgWnklnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaai

DSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
.   | | . ...| .   .  ||.||. ..... .. |.  .|
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 416-497 1.7e-08 28.8 In-house 3-71 (130) alignment
Range on Protein: 416-497
Range on HMM: 3-71/130.0
LPYDHTRVKlstvkwqeGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstvkcDCYWPT
|... .|..        | .||||||.    . ..|. || |.|.|  .||.|. |.    .|..  ..|.     | ||| 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd

0044763 (Phosphotyrosine protein) phosphatases II 417-642 2.5e-39 130.1 In-house 1-167 (178) alignment
Range on Protein: 417-642
Range on HMM: 1-167/178.0
PYDHTRVKLSTVKWQEGSDYINASFLDGFmkpqQYIATQGPmaetiGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNerctyggvevtlvecv
|.|.|||.||.. . |.|||||||. ...     |.....|      .......|..  .||..|. .|   .||| |||.. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

planytfrtftimkggtskdlrevRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRilhgedNVDIYG
                         |.... .||||||. .  .| ... ......   .. || .|||||||||.||.|... |...      ..... 
........................iqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkkl......glslee

HVTLLRNQRNfMVQTEDQYFFIHEAI
 . |.|..|. .|....|. ...|  
aielvrerRp.ivpnpgqlrqLyefe

0046846 (Phosphotyrosine protein) phosphatases II 431-643 2.4e-43 143.2 In-house 9-170 (176) alignment
Range on Protein: 431-643
Range on HMM: 9-170/176.0
QEGSDYINASFLDGFMkpqqYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCtyggvevtlvecvplanytfrtftimk
....|||||....| .    .||||||. .|. .|..|..|..  ..|..|...|.. .||. |||   .. .                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

ggtskdlrevrQFHFTAWPDHGVPEFpTSMLSMIRCVRAHHNRlppDtGPMIVHCSAGVGRTGTFVVIDSMLQrilhgEDNVDIYGHVTLLRNQRN-FMV
           |.... |||||||.. . .|.... .| . ..   . || .||||||.|||||.|... .       | .....  . |.|.||  ..|
...........qylhlpwpDhgvpdl.elllellefirealke...g.gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgav

QTEDQYFFIHEAIN
||..|| |..|.. 
qtpeQyrflyefel

0043147 (Phosphotyrosine protein) phosphatases II 432-640 2.1e-46 153.1 In-house 3-155 (172) alignment
Range on Protein: 432-640
Range on HMM: 3-155/172.0
EGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLqekstvkcdcywptdvnerctyggvevtlvecvplanytfrtftimKG
|||||||||.||.  .|...||||||. .|. .||||..|..  .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

GTSKDLREVRQFHFTAWPDHGVPeFPTSMLSMIRCVRAHHnrLPPDTGPMIVHCSAGVGRTGTFVVIDSMLqrilhgeDNVDIYGHVTLLRNQRNFMVQT
 ...  |.. |.... |||||||  .  .|.... .. ..  .  . ||..||||||||||||.|... ||        .....  | |.|..|. .||.
dpellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqn

EDQYFFIHE
..|| |...
psqyrflyy

0051429 (Phosphotyrosine protein) phosphatases II 433-650 4.5e-52 172.7 In-house 3-228 (272) alignment
Range on Protein: 433-650
Range on HMM: 3-228/272.0
GSDYINASFLDGFMK---PQQYIATQGPMAETIGEFWRMvWEQNSATIVMVTKLQEKSTVKCDCYWP----------TDVNERCTYGGVEVTLVECVPLA
 |.||||....|. .   |  .....||.  |. .|||. .|..  |||..... |.  .|||.|||           |. .. .|| . |||.... | 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

NYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEfpTSMLSMIRCVRAhhnrlppdTGPMIVHCSAGVGRTGTFVVIDSMLqRILHGEDNVD------
.|. |......  . .. |||...|.|.|||||||.   ..|.... ...         ||..||||||..||||.|... .| . .. |. ||      
dyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltn

--IYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAiACGV
  ... |  || ||  .||||.|| |..||. |. ....
lyleeaveelraqrpgavqteeqylflyeallel.lrsl

0036282 (Phosphotyrosine protein) phosphatases II 433-640 1.3e-50 166.8 In-house 1-164 (174) alignment
Range on Protein: 433-640
Range on HMM: 1-164/174.0
GSDYINASFLDGFMKPQQYIATQGPMAetigeFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvnerctyggvevtlvecvplanytfrtftimkgG
||||||||.||... .  .||.|||.|     ||.|..|... |.||.....|.  .||  |||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

TSKDLREVRQFHFTAWPDHGVPEFPTsMLSMIRCVRAHHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILhgEDNVDIYGHVTLLRNQRNFMVQTE
 .   |.. |.... |||||||.... .|.... |. ....  .. ||..||||||||||||.|... ||...|  |. ||.. .|  ||.||  ||||.
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp

DQYFFIHE
.|| |...
sQyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 433-642 1.7e-35 117.2 In-house 2-149 (151) alignment
Range on Protein: 433-642
Range on HMM: 2-149/151.0
GSDYINASFLDGFmkpqqYIATQGPMAetigEFWRMVWEQNSATIVMVTKLQEKStvKCDCYWPTDVnerctyggvevtlvecvplanytfrtftimkgg
 |||||.|...|.     .....||.|    .|.....|..  |||......|    .| .|.|                                    
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tskdlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhhnrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRilhgednVDIYGHVTLLRNQRNFMVQTE
     .||...... |||.|.|... ..|.... ...      .. ||..||||||.|||||.|... ||..       |...  .  .| .|  .||..
.....ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpn

DQYFFIHEAI
.|..|.. |.
qqflfqlfal

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 436-513 1e-08 29.1 In-house 124-196 (244) alignment
Range on Protein: 436-513
Range on HMM: 124-196/244.0
YINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstvkcDCYWPTDVNERCTYGGVEVTLV
||||||.  . .  .|| || |.|.|  .||.|. |.    .|..  ..|.     | |||           . ||| 
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtlt

0049260 (Phosphotyrosine protein) phosphatases II 441-640 2.1e-42 139.7 In-house 1-144 (152) alignment
Range on Protein: 441-640
Range on HMM: 1-144/152.0
FLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWptdvnerctyggvevtlvecvplanytfrtftimkggtskdlrev
|.||...|...||||||. .|. .||||..|..  ||||.|.|.|.  .||. |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrLPPDTGPMIVHCSAGVGRTGTFVVIDSMLqrilhgeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHE
 |.... |||||||...  .| ... .. .   .  . || .||||||||||||.|... ||        .|...  | |.|..|. .|....|..|..|
.qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye





subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 443-507 3e-10 34.0 In-house 230-290 (440) alignment
Range on Protein: 443-507
Range on HMM: 230-290/440.0
DGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKStvkCDCYWPtdVNER-CTYGG
.|. | . .|||| |.  |. .|||.| . . .||.|. .|..|.   |  |||  || |  |.| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywp..vntrsvtfgp

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 447-612 8e-25 82.4 In-house 26-185 (255) alignment
Range on Protein: 447-612
Range on HMM: 26-185/255.0
KPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVEcvPLANYTFRTFTIMKG-GTSKDLREVRQFHF
||..    .   . |. .|....  ... ..||.. ..|.. .||. |.|.. .|.  .  |.||  .  . |.  .|| .|.   |  |  ..|. ...
kPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysy

TAWPDHGVPEFPTSMLSMIRCVRahhnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHG---EDNV
. |...  || .  .| ... ||        |. ...||||.|.||. .||..... |....     . |
kGWieknaPelareilnilkvvr........dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 449-639 1.3e-26 88.0 In-house 5-197 (199) alignment
Range on Protein: 449-639
Range on HMM: 5-197/199.0
QQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTS-KDLREVRQFHFTA
..||||| |. ||. .||.||||  |  ||||   | .  .    ||||  .    || . ||    .  ..||  .. . .  |.    ||. .. ||.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEFPTsMLSMIRCVRAHHNRL-PPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGE-DNVDIYGHVTLLRNQRNFMVQTEDQYFFIH
| ..  |.    .. .. . |   ..       |.||||| | | || || .|  ..         ||..     ||. |  .. . ..| ||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 449-639 1.4e-26 87.9 In-house 4-196 (198) alignment
Range on Protein: 449-639
Range on HMM: 4-196/198.0
QQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTS-KDLREVRQFHFTA
..||||| |. ||. .||.||||  |  ||||   | .  .    ||||  .    || . ||    .  ..||  .. . .  |.    ||. .. ||.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEFPTsMLSMIRCVRAHHNRL-PPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGE-DNVDIYGHVTLLRNQRNFMVQTEDQYFFIH
| ..  |.    .. .. . |   ..       |.||||| | | || || .|  ..         ||..     ||. |  .. . ..| ||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 455-645 4e-22 73.0 In-house 97-287 (302) alignment
Range on Protein: 455-645
Range on HMM: 97-287/302.0
QGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVEC-VPLANYT----FRTFTIMKGG---TSKDLREVRQFHFT
  |  .|.  .| .. . | | .| .... |.   ||  |. ..|... ..|   |. |.    |...|    |. .|.       ..|  . |  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPEFPTSMLSMIRCVRAHHNRlppdtgpMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
|||||| |. . . | ...   .. .        ..||||||||||||.| |   .|  .. ..  |.   |. .|. |   ||.|.|  ..   .  .
awpdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtkg

subfamily_hpo-7_pd Subfamily hpo-7 458-611 9.7e-21 68.8 In-house 43-190 (263) alignment
Range on Protein: 458-611
Range on HMM: 43-190/263.0
MAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPlaNYTFRTFTIMK-GGTSKDLREVRQFHFTAWPDHGVPEF
. .|| .|....  ... ..||..  .|.. .||. |.|.. .|.  .  |.|.  . .   .   .|  ...  |  | ...|... .. |...  || 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PTSMLSMIRCVRAHHnrlppdtgPMIVHCSAGVGRTGTFVVIDSMLQRILHG---EDN
. ..| ... .|  .        ...||||.|.||.  |.|.... |....     . 
areilnilkvarnsk........slvvhcstGiGrsaafsvaElvyqkmirsldttst

0048076 (Phosphotyrosine protein) phosphatases II 494-642 5.3e-28 92.9 In-house 2-139 (145) alignment
Range on Protein: 494-642
Range on HMM: 2-139/145.0
YWPTDVNERCTYGGVEvTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlppdTGPMIVHCSAGVGRTG
|||. . ..  .|..  | ..   |... ..|   .   ..   |.. |.... |||||||...  .|.... .......     ||..|||||||||||
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtg

TFVVIDSMLQrilhgeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
|.|... ||.       .|...  . |.|.|| ..|....|. |..|..
tlvaaylmll......lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 512-682 5e-30 99.2 In-house 68-230 (440) alignment
Range on Protein: 512-682
Range on HMM: 68-230/440.0
LVECVPLANYTFRTFtiMKGGTSkdlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDN
 |. || ..|   ..  ..|  |   | ..|.|. .|||.|||.|   .| ||. |   ...     ||..||||||.||||  ...||.|.   .  |.
evkgvpdsdyinasy..ingies...rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka..gngpllvhcsagagrtgviiavdsilrea.krsdq

VDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLELIQEDGESSLLEMEFQ
.||.  .  .||.|  |||| .|| |.|||. |.. || | .  |.   ......  .   . | |. ||.
idifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe

0048179 (Phosphotyrosine protein) phosphatases II 532-640 8.9e-26 85.7 In-house 41-139 (144) alignment
Range on Protein: 532-640
Range on HMM: 41-139/144.0
GTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlppDTGPMIVHCSAGVGRTGTFVVIDSMLqrilhgEDNVDIYGHVTLLRNQRNFMVQT
      ||. |.... |||||||.... .|.... ......    . ||..||||||||||||.|... |.      . .....  . |.|..| ..|..
epefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpn

EDQYFFIHE
..|. |..|
pgqlrfLle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 537-642 2.3e-17 57.8 In-house 214-340 (350) alignment
Range on Protein: 537-642
Range on HMM: 214-340/350.0
LREVRQFHFTAWPDHGVPEFPTSMLSMIRC-------VRAHHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQ--RILH----GEDNVD--------IY
  .| |...  |.| ..   | |.|... .         |.       . |..||||||||||||.| .||.|.   ||.       ..|        | 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

GHVTLLRNQRNFMVQTEDQYFFIHEAI
  |  ||.||  |||. ||. ||.||.
iivnelrkqrismvqnldqfifiYeal

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 539-641 2.7e-10 34.1 In-house 219-339 (349) alignment
Range on Protein: 539-641
Range on HMM: 219-339/349.0
EVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA----HH--NRL-PPDTGPMIVHCSAGVGRTGTFVVIDSMLQrILH---GE--------DNVD-IYGHVT
|. |. .  |.| ..   | |.|  . .        .  . |   .. ...|||||| ||||..| .|..|. ||.    |           | |.  | 
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls.ileplqnesnkiklqallkDlisiivn

LLRNQRNFMVQTEDQYFFIHEA
 || ||  |||   |. .|.||
elrkqrismvqnlaqfiaiyea

PTPc_DSPc_SM00012 540-643 4.8e-37 121.7 In-house 2-104 (105) alignment
Range on Protein: 540-643
Range on HMM: 2-104/105.0
VRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPPdTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIH
|...|.|.|||||||| ..|.|...| |. ..|     ..|..||||||||||||||..| .||.. .....|||.  |  ||.||. |||||.||.|..
vkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAIN
.|..
rall

0038934 (Phosphotyrosine protein) phosphatases II 541-598 7.9e-08 27.7 In-house 80-135 (194) alignment
Range on Protein: 541-598
Range on HMM: 80-135/194.0
RQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPPdtGPMIVHCSAGVGRTGTFVVI
 ...   .||.|..     .|. .. |  ..|. |.  |   ||| ||.|||||.|. 
ieylklpfpddgtvPsleillrfldlvdeflnedpg..gvvaVHCkaGlgRtGtlvaa

subfamily_PTPDC1_pd Subfamily PTPDC1 543-640 2e-07 25.6 In-house 85-170 (182) alignment
Range on Protein: 543-640
Range on HMM: 85-170/182.0
FHFTAWPDHGVPEFpTSMLSMIRCVRAHHnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNvdiyghVTLLRNQRNFMVQTEDQYFFIHE
..  .|.|.||.   ...| ... |         . | . ||| || ||||  .    . .. | .|.       ..|.|..|   .|| .|  ...|
vynfgwkDygvasl.eriLdivkvvafal.....qegkvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvke

PTEN_1 547-596 9.6e-06 20.5 In-house 101-148 (196) alignment
Range on Protein: 547-596
Range on HMM: 101-148/196.0
AWPDHGVPefPTSMLSMIRCVRAHHNRLPPDTGPMIVHCSAGVGRTGTFV
 ..|||.|  . |.|  | .. ..  .. |. .  .||| ||.||.|| |
pieDhgap..slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

subfamily_CG42327_pd Subfamily CG42327 577-643 8.6e-15 49.2 In-house 246-312 (319) alignment
Range on Protein: 577-643
Range on HMM: 246-312/319.0
DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
. ||..|||| ||||||. .  |  .... . .  |||   |  .|..|   |.| .|| ||.  . 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 581-649 1.4e-17 57.9 In-house 1-68 (69) alignment
Range on Protein: 581-649
Range on HMM: 1-68/69.0
MIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACG
|.||||.| ||||||. |   . ||   |  |||.  |  .|  |  ||  | .| |||.|. ||.  |
mvvhcssgtgrtgtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 582-649 4.2e-17 56.3 In-house 1-67 (69) alignment
Range on Protein: 582-649
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACG
.||||.| ||||||. |   . ||   |  |||.  |  .|  |  ||  |..| |||.|. ||.  |
vvhcssGtGrtGtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 649-924 3.7e-78 257.8 In-house 1-276 (298) alignment
Range on Protein: 649-924
Range on HMM: 1-276/298.0
GVTDVTSDQFPVHLDKLELIQEDGESSLLEMEFQRLATDRT--EPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRA
| |.......  .| ||. .... . . ...||||| .     | .    | |. || |||. .|..... || |. . | | |||||||....|... |
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPeASYTLHHFQFLGWPERG
..|||.|...||||||||..|.... |||||.|||...     || | .....||||..| .|.|  |.  |..|... ..   . ......|  ||..|
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkg

VPVSALPLLQMIQNVQElYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
||  |  .|.....|.  . .    .|..| ||.||||.| |||.  ||||   | ..|.||.||.||..| ..|||.
vpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

subfamily_PTPRB_pd Subfamily PTPRB 653-924 2.1e-78 258.3 In-house 7-271 (293) alignment
Range on Protein: 653-924
Range on HMM: 7-271/293.0
VTSDQFPVHLDKLeliQEDGESSlLEMEFQRLATDRtEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQG
.. ..|  |..|.   ..| .   .  |...| .   . .  ..|...||. |||. ||.||...||||. .. ..|||||||.||. |...| ..||||
iklekfeehvkkm...kadsdlr.fseeyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL-ESRQFGEITIELIKKKEEIDYLHRQFKIAHleqPEASYTLHHFQFLGWPERGVPVSA
|. .||.|||||.||.||.||||||.| || ..    || .  |. ..|.|...|....|  |.  |..|| .    ... ......|. ||. ||| ..
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

LPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 .||.....|.|   .  ...||.| ||.||||||.||||  .|.. . | ..|.| .|  || .|  .||| 
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqte

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 656-923 1.4e-47 157.1 In-house 5-264 (439) alignment
Range on Protein: 656-923
Range on HMM: 5-264/439.0
DQFPVHLDKLEliqeDGESSLLEMEFQRLATDRTEPHRFA-SATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPM
|.|  |..||.      .  ... .|. . . . . .  |  |... .. |||. .. .... || |  |     | |||| ||. | ... |.||||| 
defqehvekld....knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

KNTVEDFWRMIWEHKSKIIVMLTKLEEKQQecsflYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIA-HLEQPEASYTLHHFQFLGWPERGVPVSALP
|.|..||||...|.|.  |||||.| |  .     ||   .   .|.|..   .. |  .|  | ||.  . .. |   |. .|... ||.. ||  |  
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

LLQMIQNVQELYiTLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQT
.|.... ..      . . |. | ||.||||||  ||| | ||.  .|  .|.   || || ||  |||.
vldflrainsan.dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqa

subfamily_PTPRA_pd Subfamily PTPRA 658-927 6.1e-80 263.6 In-house 12-284 (330) alignment
Range on Protein: 658-927
Range on HMM: 12-284/330.0
FPVHLDKLEL---IQEDGESSLLEMEFQRLATDRTEpHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPM
||. ..|||    |.   .. |.  ||. | . . .   .  |.|. || |||.|||.||...|| || .. .| |||||||.|| |...  ..|.||| 
fplpvekleeeirirsaddnklfreefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

KNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQ---PEASYTLHHFQFLGWPERGVPVSA
..|||||||||||.||  |||||.|.|...|    || |  .  .|.|..|. .... .||  |.| . .| .    ..|  .. | | .||. |||. .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

LPLLQMIQNVQELYitLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQ
  .|.....|..|    ....||.| ||.|||||| ||.|  ||||   |...|.|..|| || ||. ||||    
iGmlkllkkvkkln..qqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 660-924 1.2e-86 285.6 In-house 9-266 (318) alignment
Range on Protein: 660-924
Range on HMM: 9-266/318.0
VHLDKLELiqeDGESsLLEMEFQRLATDRTEPHRFASaTKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVE
 |. .|.    .||  ||. |..||. .. .. .. | ...||| |||..||..|.  ||||. .  .||||||||.||| ||...||.|.|.|. .|.|
shvrrlre...sGel.llseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHlEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQ
|||||.|| .|..|||||..||. ..    || . .||..|....|| ...|  ||. |.||. . .. |.| . . ...  ||..||| |.  ||....
DfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvr

NVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
.|..   .  ...||.| ||.||||||||||. |.|||   |...|.|||||.|| || .||||.
qvskaqqk.sgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

0045450 (Phosphotyrosine protein) phosphatases II 661-924 4e-75 248.7 In-house 13-290 (307) alignment
Range on Protein: 661-924
Range on HMM: 13-290/307.0
HLDKLELIQEDGESSLLEMEFQRLATDRTE-PHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYI--------DSYRQQRAYLAT
.|..| |..     ..|. ||..|    .. .. . .| . .|| |||...|.||...||||| .  . |.||||||||.        |.|...|...||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL-ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPV
|||...||||||||.||.....|||||.|.|. .|  . ||.|  |. ..|..|..|...... .| .|.... .|.. . | |..||...|||. ||| 
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGM---IDLFQTVKTLRIQRSAMVQTR
|  .||..|. |.. . .|.  .|. |.|| ||||||.|||. ..|..   ||.   .||...||.|| ||. .||. 
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

subfamily_PTPN6_pd Subfamily PTPN6 661-931 3.3e-69 228.2 In-house 12-290 (306) alignment
Range on Protein: 661-931
Range on HMM: 12-290/306.0
HLDKLELIQEDGESSLLEMEFQRLATD-RTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfIRATEGSDYINASYID--SYRQQRAYLATQGPMKNT
. ..||  .|. | . .| ||..| ..  .. .    ..|. || |||. ||.|.. .||.|.    . |||||||.||.  .  ....|.|||| ...|
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

VEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE-SRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQ
|.|||||.|. .|..|||.||  |. .|    || | | ....|.|... ...|.  ||  |...... .. . . ......|  ||. ||| .   .|.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLd

MIQNVQELYITLR--TTEPITVMCSSGVGRTGVFIALGIVLERYSVEG---MIDLFQTVKTLRIQRSAMVQTRLSQKKIV
....|.. . .|.  .. || | ||.|.|||| || . |.|.  . .|    ||. ..||..| ||| .|||    | . 
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvy

0050432 (Phosphotyrosine protein) phosphatases II 662-924 1.4e-82 272.8 In-house 29-285 (308) alignment
Range on Protein: 662-924
Range on HMM: 29-285/308.0
LDKLELIQEDGESSLLEMEFQRLATDRTePHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfiraTEGSDYINASYIDSY--RQQRAYLATQGPMKNTVE
|| |.|...  ...|||.||..|    . .. . .| .  || |||...|.||...||||      ||||||||||.| |  ...|...|||||..||||
ldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL---ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPeASYTLHHFQFLGWPERGVPVSALPLLQ
|||||.||.....|||||||.|...|  . || .    .|...| .|..|.. ... || .|.... .|. .  | |..||....||. ||| |. .||.
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilld

MIQNVQELYitlrTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
... |.. .      .|| |.|| ||||||.|||| ..||..  ||..|.|..||.|| ||  |||| 
flelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 663-740 5.5e-09 29.8 In-house 10-85 (440) alignment
Range on Protein: 663-740
Range on HMM: 10-85/440.0
DKLELIQEDGESSLLEMEFQRLATDRTEPHRFASATKnvNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDS
|  . .|..  |   | |.  | .  ..|   ||  .  || |||. ||. |...|| |  ...   |||||||||..
dfadyvqnnrrsrafedewsllpsglsqpsdiaslpn..nkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 665-931 4.2e-84 277.3 In-house 14-275 (319) alignment
Range on Protein: 665-931
Range on HMM: 14-275/319.0
LELIQEDGEsSLLEMEFQRLATDRTEphRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRM
|. ... ||  ||| ||. | .  ..   | ||.|. || |||. ||..|.  ||.|| .  .|||||||||.||.|.......|||.|..||.||||||
lkalastge.tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

IWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQEL
.||..| |.|||||| || .     ||.. .  ..|.....| ...|  ||  |..|. .. .   . .. |||.. ||. .|| .|. ||........ 
vWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

YiTLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKIV
     .  ||.| || |||||| ||.| ..||| . ||..|.|.||..||.||  |||.  .| |..
r.ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp.eqYkfi

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 666-925 5.5e-63 207.8 In-house 17-271 (297) alignment
Range on Protein: 666-925
Range on HMM: 17-271/297.0
ELIQEDGESSLLEMEFQRLATDRTEPHrfASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQqrAYLATQGPMKNTVEDFWRMI
 |.|.. .... . ||. | .  . |     | |.||  |.|. ||.||. .||||  .     |||.|||.. ....   ...|| |||.||.|||.|.
tlvqknrhtdvfseeflclpeaniqpq..tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamv

WEHKSKIIVMLTKLEEKQQECSfLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHlEQPEASYTLHHFQFLGWPERGVPV--SALPLLQMIQNVQE
.... ..||||....|....|   ||||  . .||.....|   .|   ...|...... ... |   .. .||. ||.. |.   ||  ||..|..|..
ldeqvstivmlnddnerdkkca.ryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrk

LYITLRTTePITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
 . .   . |. | |..|||||||....  |. .   |  .|.|..|| || .|  .|||. 
dfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtke

0039614 (Phosphotyrosine protein) phosphatases II 667-924 4e-76 251.6 In-house 24-275 (297) alignment
Range on Protein: 667-924
Range on HMM: 24-275/297.0
LIQEDGESSLLEMEFQRLATDRTEphrFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYIDSYRQ-QRAYLATQGPMKNTVEDFWRM
|.    ...||..||..|     .   .  | . .|| |||...|.||...||||. .. . ..||||||||.| |.. .|...|||||...||||||||
llekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

IWEHKSKIIVMLTKLEEKQQeCSFLYWSDLESrQFGEITIELIKKKEEIDYLHRQFKIAHleqPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQEL
.||.....|||||||.|... . . ||.. .. ..|..|..|.| ... .| .|.... .    . |.|..|||..|||. ||| |.  ||.... |.| 
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrea

YITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
. .|.  .|. |.|| ||||||.|||. ..||..  || .|....||.|| ||. .||| 
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 667-925 4.9e-48 158.5 In-house 12-223 (392) alignment
Range on Protein: 667-925
Range on HMM: 12-223/392.0
LIQEDGESSLLEMEFQRLATDRTEPHRfaSATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIW
.....  |.|.  ||. |      |..  .| |..|. |||. ||.||. .||||  |  .  |||.|||||.|. ...||.|.|||   ...|||||..
fveknrhsalffeefhdlpgpdiypqt..vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

EHKSKIIVMLTKLEEKQqecsflywsdlesrqfgeitielikkkeeidylhrqfkiahleQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYI
...   |.|.|||.| .                                           . .   |   |.|  ||...||  .  ||..|..|.  . 
qenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG

TLrtTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
    | |. . ||.||||||| |..  |. .     |.|.|. |  .| .|  ||||. 
qy..thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtke

subfamily_PTPN3_pd Subfamily PTPN3 668-931 1e-55 183.6 In-house 8-267 (280) alignment
Range on Protein: 668-931
Range on HMM: 8-267/280.0
IQEDGESSLLEMEFQRLATDRTEpHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfirATEGsDYINASYID----SYRQQRAYLATQGPMKNTVEDFWR
..|. ||  . ..|..|   . .      | |  |  |||. .|.||.  ||||.   ..|  |||||.|..    |  .   |.|||||...|..|||.
lkeglesGavlaqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWq

MIWEHKSKIIVMLTKLEEKQQECSFLYWSDL-ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQ
|.||.||..||||| | |. .     || .  .. ..||..... |..|.  |. |.. . . |. | . .....|.| ||. ||| ..  .|.....|.
mvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervr

ELYitLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKIV
.|     ..||. | ||.|.|||||.|.| . |     .  .   . |.|.| ||...|||  || | |
klr..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta.sqykfv

subfamily_PTPN14_pd Subfamily PTPN14 669-935 9.2e-54 177.5 In-house 17-292 (300) alignment
Range on Protein: 669-935
Range on HMM: 17-292/300.0
QEDGESSLLEMEFQRLATDRTePHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATeGSDYINASYIDSY--RQQRAYLATQGPMKNTVEDFWRMIW
..  |.. . .|..|..  |.    . .|. ..|. |||| ...||| |||.||  . .  ..||||| |      ..| |...|||...||.|||.|.|
ekkleegkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvW

EHKSKIIVMLTKLEEKQQECSFLYWSDLES----RQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQ
|.. ..|||||. ||. .| || |. .|||     .||.  .    ...   .  ...|. ||   |   |..|.|.  ||..|||    . |. ...||
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske.ertvwhlqytDWpdhgvPeDvkgflsyLeevq

ELYITLRTTE-------PITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKIVLSLK
 .     ..        |. | || ||||||| |   .... .  .  ||. .....|| ||  .||| |.| | | .. 
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt.laqYkfvYkvl

0051299 (Phosphotyrosine protein) phosphatases II 671-924 2.1e-82 272.1 In-house 19-272 (288) alignment
Range on Protein: 671-924
Range on HMM: 19-272/288.0
DGESSLLEMEFQRLaTDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKS
 .  ..|..||..| .. .... . .| .  |. |||...|.||...||||| .   |||||||||||| |...|...|||||..|||||||||.||...
angltglleefeel.lsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

KIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLE---QPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIt
..|||||||.|...| .. ||.. .| ..|.||..|.. ... || .|.... .|.   ... |.| .||....||. ||| |. .||.... |.. .  
rvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.

lRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
  .  |. |.|| ||||||.|||| ..||..  ||..|....||.|| ||  |||| 
.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 671-930 6.8e-71 234.2 In-house 30-282 (319) alignment
Range on Protein: 671-930
Range on HMM: 30-282/319.0
DGESSLLEMEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKS
| . . ||.||.|..   ..    . |  . || |||..||.... |.|||  .   |.|||||||... |...  |.|.|||..||..||||||||...
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

KIIVMLTkleekQQECSfLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRT
  ||.||     .. ||  ||      . ..  ...   .|  .|  |......  . .    .. | |||||. ||| .. .|......|. |    . 
stivllt.....kdkcs.qywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

TEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKI
 ..| | ||.|||||||.|.| ..|.|   | ..|....|. || ||. .||  | | |.
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd.lvqykf

0047943 (Phosphotyrosine protein) phosphatases II 672-924 4.6e-79 261.0 In-house 9-258 (273) alignment
Range on Protein: 672-924
Range on HMM: 9-258/273.0
GESSLLEMEFQRLaTDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfirATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSK
  ..||..||..| .. .... .  | .  || |||. .|.||...||||      .|||||||||.| |...|...|||||..|||||||||.||....
lgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

IIVMLTKLEEKQQECSFLYWSDLE---SRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITL
.|||||.|.|...|  . ||.. .   | ..|..|..|.. ... || .|.... .|. .| |.| .||...|||. ||| |  .||..|. |.. . .|
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkaleal

RTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
.  .|. |.|| ||||||.|||| ..|...  ||..|....|| || ||  |||| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

0036941 (Phosphotyrosine protein) phosphatases II 672-924 5.4e-76 251.0 In-house 10-263 (297) alignment
Range on Protein: 672-924
Range on HMM: 10-263/297.0
GESSLLEMEFQRLaTDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfirATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSK
  ..||. ||..| ...  .  .  | .  |. |||. .|.||...||||      ||||||||||.| |...|...|||||..|||||||||.||....
lflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

IIVMLTKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKE--EIDYLHRQFKIAHLEQPeASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIT
.|||||.|.|.. |  . ||..   || ..|..|..|.. ..  . ||  |.... ... .  |.|..||...|||. ||| |. .||..|. |.. .  
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkl

LRTTEPITVMCSSGVGRTGVFIALGIVLERYS---VEGMIDLFQTVKTLRIQRSAMVQTR
|.  .|. |.|| ||||.|.|||. ..|...     || .|....||.|| ||  .||| 
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 672-924 6.4e-63 207.6 In-house 15-262 (515) alignment
Range on Protein: 672-924
Range on HMM: 15-262/515.0
GESSLLEMEFQRLATDRTEPHRFasATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSK
.  .|.  ||. |      |     | ...|  |||. ||.||. .||||  |     |||.||||| |.  ..||.|.||| | .|.||||......  
rhttlfseefhdlpgpniypqtv..aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

IIVMLTKLEEKQQECSFLYWSD--LESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQpeaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELyiTLR
 |.|.|||.|  .     || |   .| .||.| .||.  .   . . |.... . ..   | |.  |.| .||..|||  .  ||..|..|.    . .
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkad..hgq

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 | |. . ||.|||||||.|..  |. .     |.|.|..|. .| .|  .|||.
ythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtq

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 673-924 5.1e-63 207.8 In-house 17-263 (315) alignment
Range on Protein: 673-924
Range on HMM: 17-263/315.0
ESSLLEMEFQRLATDRTEPHRfaSATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKI
 ..|.  ||. |    . ..|  .| ...|  |||. ||.|.. .||||  |  .  ||||||||| |. ...||.|.||| | .|.|||||....|   
htalfseefhdlpdPdiyrqr..varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMLTKLEEKQQ-ECSfLYWSD--LESRQFGEITIELIKKKEEIDYLHRQFkiaHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELyiTLR
|||.||..|  . .|   || |   .| .||.| .||.. .   |  .|..    . . |.| |.  ||| .||..||.  .  ||..|..|.      .
ivmvtkkqegdkikcr.qywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngk

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 . .. | ||.|||||||.|..  |...   . ..|.|..||.|| .|  .|||.
kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte

subfamily_PTPN23_pd Subfamily PTPN23 673-930 3.4e-58 191.8 In-house 13-272 (288) alignment
Range on Protein: 673-930
Range on HMM: 13-272/288.0
ESSLLEMEFQRLATDRTEP-HRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQ-RAYLATQGPMKNTVEDFWRMIWEHKS
. . |. .|. | ..  .  . .. |  ...  |||. .|.||. |||||      .  ||||||.. .   .   ..|||.|...|. |||.|..| ||
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

KIIVMLTKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITL
..||||.. ||....    ||     |. .||.... | ...|   . .|..|. .|.. .| ... | |.  ||| ||| |   |||....|.. | . 
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasPetllqfldevesayeav

--RTTEPITVMCSSGVGRTGVF-IALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQKKI
  ..  |. | ||.|||||||| .  ..| | .  .|..|. | |..|| ||  |||..   |. 
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 673-923 1.2e-17 58.2 In-house 24-270 (302) alignment
Range on Protein: 673-923
Range on HMM: 24-270/302.0
ESSLLEMEFQRLATDRTEPHRfASATKNvNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTV---EDFWRMIWEHK
... .. ||....| ...  .  .| |. |  ||.  ..  .. |.|||.    .|  .|.||| ..    .|  . .| | ....   |.||||....|
dtaevkkefkkidtmkvdlek.Ckafkk.nlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

SKIIVMLTKLEEKQQECSFLYWSDLE-SRQFGEITIELiKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQF-LGWPERGVPVSALPLLQMIQNVqeLYIT
 . .|.| . || ..  | |.    .   ..|.. .   .| |. .  . .. |  | .  .   |   .    |..  |||.   | . ...|     .
ivsvvilvgeeelkktlselfpkksgdykeygkmfvNn.rkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakk

LRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQT
  ..|.. ..   |.|| |.|..| ...|.   .      ..||..| ||...|..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravds

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 674-924 2.2e-76 251.9 In-house 21-269 (305) alignment
Range on Protein: 674-924
Range on HMM: 21-269/305.0
SSLLEMEFQRLATDrtePHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
.. ||.... |...   .. .   .|..|| |||...|.... .|..|.    .. ||||||||.|.|... .|...|||.||||.||||.|.| | . |
dkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTKLEEKQQECSFLYWSDLESR--QFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRTT
|||||| | ....   || . ...  .|||...||  .|.  ||. |..||.  .. . | |. ..|.  ||. ||| .|  ||..|..||. .      
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

EPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 |..| || ||||||||||. | |||   |...|.|. .|.|| .|  |||| 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

0043336 (Phosphotyrosine protein) phosphatases II 674-924 3.5e-74 245.1 In-house 19-263 (278) alignment
Range on Protein: 674-924
Range on HMM: 19-263/278.0
SSLLEMEFQRLATDRTepHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
 .||. ||..| .  .    .  | .  || |||...|.||...||||| .   ..||||||||.| |...|...|||||...||||||||.||.....|
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLTKLEEKQQECSFLYWSdLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAsYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEP
||||.|.|.... .. ||.  .| ..|..|..|.| ... || .|.... .|  .|  .| .|...||||. ||| |  .||.... |.| .      .|
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale..dsngp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
. |.|| ||||||.|||| ..||..  || .||...||.|| ||  .||| 
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

0040438 (Phosphotyrosine protein) phosphatases II 675-924 6.3e-76 251.0 In-house 18-262 (317) alignment
Range on Protein: 675-924
Range on HMM: 18-262/317.0
SLLEMEFQRLATDRTEphRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 .|. ||..| .   .   .  | . .||.|||...|.||...||||| .   ..||||||||.| ....|...|||||..|||||||||.||.....||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLeQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEPI
|||.|||...| .. ||.. |. ..|..|..|.. .|. .. .|.... .| . . | |..||...|||. ||| |  .||.... |.| .   .  .|.
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpv

TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 |.|| ||||||.|||. ..||.   || .|....||.|| ||. .||| 
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

subfamily_Ptp69D_pd Subfamily Ptp69D 675-927 2.1e-69 229.0 In-house 22-274 (307) alignment
Range on Protein: 675-927
Range on HMM: 22-274/307.0
SLLEMEFQRLATDrTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 .|. |...| .  . ..    . |. |. |||. .|.... .||||. |  .| |||||||.| .|.... ..| |.|. .|..||||||.| ....||
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLE----QPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrt
||..|.||...    ||.. .  |.|.| ..|.....  || .|...... .    . |.|  .  ....||..  || .|  ||..|..|.||| .   
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

TEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQtRLSQ
  ||.| || ||||.|.|.|| ..|..   |  .|.|.||| || ||. .|| .| |
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvq.sleq

subfamily_PTPRN_pd Subfamily PTPRN 675-931 1.3e-52 173.4 In-house 29-284 (297) alignment
Range on Protein: 675-931
Range on HMM: 29-284/297.0
SLLEMEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYI-DSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
. || |.. |.. ..||.  . | .. |  |||  ...||. .||||.   ..| ||||||| | |.  .. ||.|||||. .|| |||.|.||. . .|
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEE-IDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRtTE
|.||.|||.. .    || |  |  ..   ..|. ..    ||| | | .  |.. | . |.  | || |||.||| || .||.. . |.  |   | . 
vnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPasaksllefrrkvnksyrG.r.sc

PITVMCSSGVGRTGVFIALGIVLERYSV-EGMIDLFQTVKTLRIQRSAMVQTRlSQKKIV
|| | ||.|.|||||.|.. .||.|       ||.  |.. || ||. .|.|. .| ...
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktk.dqfefa

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 675-924 1.7e-38 127.1 In-house 6-245 (267) alignment
Range on Protein: 675-924
Range on HMM: 6-245/267.0
SLLEMEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
  .| ||. .    ..  . .    . |. .||. . .||. .|| |.    |.  .||||||...|....|...||.|.|||. ||. .| ..|  .||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTKLEEKqqECSFLYWSD-LESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQflGWperGVPVSALPLLQMIQNVQELYITLRTTEP
.|||  .   .   ..     ..... ..|.|   .||| ||    ...   ..     ||....   |    . .   | |. .  .           |
lltkvftd..nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyyk..kw...nintnnkpylkplfgilaknqlengnrP

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
. | || ||||.| |. .   |||   ||. |.|. .. .| || ..|.|.
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 676-924 4.1e-73 240.9 In-house 22-265 (288) alignment
Range on Protein: 676-924
Range on HMM: 22-265/288.0
LLEMEFQRL-ATDRTEPHRfaSATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 .. |.. | | ..|. .    . . ||. |||. ||.||...||||     ..|.|||||||||.......|.|||||. .||.|||....|.|.. ||
gfseeynsLaalektksvt..agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv

MLTKLEEKQQECSFLYWSDLES-RQFGEITIELIKKKEEIDYLHRQFKIAhleQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrtTEP
|||.| |....    || | .  ...|..|..|...||. |...|.. .    . .  ......|.|.||. ||| |. |||.....|.        |.|
mltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|.| || ||||||.||||  ....   | .||.. ||. || ||  .||| 
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtl

subfamily_PTPRG_pd Subfamily PTPRG 676-924 1.5e-69 229.7 In-house 20-273 (563) alignment
Range on Protein: 676-924
Range on HMM: 20-273/563.0
LLEMEFQRLATDRTEP-HRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGS-DYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
 .. ||. | .  ..      .. |. || ||| .||..|.  ||||| .  .... |||||.||| |....|..|||||.|.|..||||||||....||
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

VMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQP-----EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVqeLYITL
||.|.|.|....  . ||   || ..|.... ||...  . |  |...| .|.       .   .  ....  ||. ||| ..|| |....     . . 
vmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saank

RTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
... ||.| ||.||||||..|.|  .|..   | ....|...|..| ||  .|||.
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 676-928 1.6e-61 202.9 In-house 16-266 (281) alignment
Range on Protein: 676-928
Range on HMM: 16-266/281.0
LLEMEFQRLAT-DRTEPHRfASaTKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 . .|.. ||  .. .. . || ... |. |||..||. |.  |||..   ... .|||||.....|.....|.|||||. .....||.|.||.| ..||
Gfieeyeklaaigvdntat.as.kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTKLEEKQQECSFLYWSDLE-SRQFGEITIELIKKKEEIDYLHRQFKIaHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYiTLRTTEP
|.|.  |. .     || | . . ..|..|.. ....|.  |..|.||. . |. | . ........ ||. ||| ..  ||.  ..|..|  . .|  |
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresge.treveqlaytaWPdhGvPattkellefrkevlklt.ekktkap

ITVMCSSGVGRTGVFIALGIVLERYSV-EGMIDLFQTVKTLRIQRSAMVQTRLSQK
. . ||.||||||..|||  .... .  . ..|. ..|. || .|  |||| .  .
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqye

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 676-925 3.6e-29 96.7 In-house 17-264 (307) alignment
Range on Protein: 676-925
Range on HMM: 17-264/307.0
LLEMEFQRLATdrTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAteGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVM
 |  ||. ||    .|.  .  . . |  |||. ..   . .|. . |  .   |||| | |.    . . ....|||..||. .|| |. ..| . ..|
alvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTKLEEKQQECSFLYWSDLESR--QFGE----ITIE-LIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitl
| |. |  .     ||   | .   |||    |... |  ||   |    .    ...  . | |..|.|.  ||.||||   |  . ... |.      
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....

rTTEPITVMCSSGVGRTGVFIALGIVLERY-SVEGMIDLFQTVKTLRIQRSAMVQTRL
  |.|. | ||.||||.|  .|. .| ..  . .   |. . |. || ||   .|| .
.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqtea

0046845 (Phosphotyrosine protein) phosphatases II 677-924 6.5e-80 263.8 In-house 2-260 (284) alignment
Range on Protein: 677-924
Range on HMM: 2-260/284.0
LEMEFQRLATDRTEPH-RFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYIDSY-----RQQRAYLATQGPMKNTVEDFWRMIWEHK
|| ||..|    . ..  .  | .  |. |||...|.||...||||. .  . |.||||||||.| |     .......|||||..|||||||||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SKIIVMLTKLEEKQQECSFLYWSDLE-SRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITL
...|||||.|.|...|  . ||.. . . ..|..|..|...... || .| ... .|. .. |.|..||....||..||| |. .||.... |.||.  |
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RTTEPITVMCSSGVGRTGVFIALGIVLERYSVEG---MIDLFQTVKTLRIQRSAMVQTR
 . .|| |.|| ||||||.|||| ..||..  ||   ..|....|| || ||  |||| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

DSPc_SM00195 677-924 3.2e-76 251.5 In-house 2-248 (263) alignment
Range on Protein: 677-924
Range on HMM: 2-248/263.0
LEMEFQRLATDRTEPhRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVML
|..||..| . ...  .. .| |. || |||. ||.||. .||||. .  .||||||||.||. ......| |||||...||||||||.||.|.||||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEI-DYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrtTEP
|. ||...|    || .   .. .||.|...|......  ..  |.... . .. | .......|. .||..||| |. ..|.... |.. . |   ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
| |.|| ||||||.|... |.|.. . | ..|.|..|| || ||  ||||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 677-924 3.2e-76 251.5 In-house 2-248 (263) alignment
Range on Protein: 677-924
Range on HMM: 2-248/263.0
LEMEFQRLATDRTEPhRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVML
|..||..| . ...  .. .| |. || |||. ||.||. .||||. .  .||||||||.||. ......| |||||...||||||||.||.|.||||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEI-DYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrtTEP
|. ||...|    || .   .. .||.|...|......  ..  |.... . .. | .......|. .||..||| |. ..|.... |.. . |   ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
| |.|| ||||||.|... |.|.. . | ..|.|..|| || ||  ||||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 677-926 1.9e-52 172.8 In-house 12-265 (287) alignment
Range on Protein: 677-926
Range on HMM: 12-265/287.0
LEMEFQRLATD-RTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFiRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVM
.. |...|  | .. .  | .|..  .  |||. ...|.. .|| ||   .  ||||||| |. ||... |..|.|||.  || ||||...|..|  ...
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LT-KLEEKQQECsFLYWSDLES-RQFGEITIELIK-KKEEIDYLHRQFKIAHLEQPEASyTLHHFQFLGWPERGVPVSALPLLQMIQNV-Q--ELYITLR
.| ..|| ...| . || . |   . |  .. |.. .. | .|  | .....||  ||   .. ...| ||..... .|. |.... .| |  ||     
mtreveearlkc.ykywPerevPmrvGGysvvlldydikePeygvralrlidletrear.vvkqldllswPdkvlaPtavglirfvldvkqhielardas

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLS
 . |. | .. |.||.|...|. ....|    | .|  ..|  || .| |.||. . 
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvq

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 677-927 3.4e-50 165.5 In-house 17-281 (301) alignment
Range on Protein: 677-927
Range on HMM: 17-281/301.0
LEMEFQRLATDRTEphRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRA--TEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
.| ....| . . .  .    ... ||  ||| || .|. ||. |.  ..  .   .||||||||.|...... |.|||||.|. ||||.||..|   ||
feeqykelkegedk..sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTKLEEKQQECSFLYWSD--LESRQFGEITIELIKKKEEIDYLHRQFKI--------------AHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMI
|.|.|.|....... ||..   || .||..|..|....   |.. ||...               . ..  .|...  .|   ||. ||       || |
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

QNVQELYITLrTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQ
..|           |. | || .|.|.||.... | ||    || .|.|| .|..| ..  .|.| | |
ddvihrqqki.gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT.Leq

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 678-938 5.4e-63 207.6 In-house 23-282 (290) alignment
Range on Protein: 678-938
Range on HMM: 23-282/290.0
EMEFQRLATdRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEG--SDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVM
. .|..| .   ..|    .. . || .||| ||..|. ||. |  |   .    .||||.||. |.....|.|||||..||. |||..||..|. ||||
rnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG-VPVSALPLLQMIQNVQELYitLRTTEPI
||.  |....    ||.| .....||..|.|.. ..  .| .|.... . .. .|. .....|.  |.. | |.  .  ||.. . ..  .   |. ..|
ltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr..krgntsi

TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKIVLSLKMTY
 | || .|||..||.|. . ...   || ||.|| .|..|||.  .|||   | ... .. .||
vvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv.qqyqgifqivlty

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 679-930 5.1e-69 227.9 In-house 2-246 (284) alignment
Range on Protein: 679-930
Range on HMM: 2-246/284.0
MEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTk
.||.|..   ..    . |  . || |||...|.... |.|||  .   |.|||||||.|  |...  |.|||||..||..||||||||...  ||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

leekQQECSfLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMC
    .. ||  ||      . ..  ...   .|  .|  |......  . .   ... | |||||. ||| .. .|......|. |    .  ..| | |
....kdkcs.qywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKI
|.|||||||.|.| ..|.|   | ..|....|. || ||. .||  | | |.
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd.lvqykf

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 679-752 3.7e-12 40.3 In-house 27-95 (95) alignment
Range on Protein: 679-752
Range on HMM: 27-95/95.0
MEFQRLATDRTEPHRFASatKNVNKGKNRFVNIMPYEYNRVKLSFIRateGSDYINASYIDSYRQQRAYLATQG
 ||. ..     |.   |   . |  ||||.||.||.  || |.  |    |||||| ..| | .. .|.|.||
nefksismtsgapytvgs..seanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 680-924 9.3e-61 200.7 In-house 28-274 (325) alignment
Range on Protein: 680-924
Range on HMM: 28-274/325.0
EFQRLATDrtEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKL
||. | .|  ..  .  |.|  || |||| |..... .|| |   .    ||||||||. .....  .||.| |. .|..|.||.. . .. ..|.| .|
efgllpsd..dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel

EEKQQECSfLYWSDL--ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAsYTLHHFQFLGWPERGV---PVSALPLLQMIQNVQELYIT-LRTTEP
......|.  || .   .|..|| . ..|.  .|  ||.||....   .. |.  ... ||. .|.. ||   | . ...||....|.|   .  ... |
dlgkdrca.vywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGet.rsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
| | ||.|||||||||.|  .|..   |  .|.|. || || .| .||.| 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 680-931 1.2e-31 104.4 In-house 16-261 (281) alignment
Range on Protein: 680-931
Range on HMM: 16-261/281.0
EFQRLATDRTEpHRFASATKNVNKGKNRFVNIMPYEYNRVKLSF-IRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTK
||  |  |       .   . ||. |||..||   .  ||.| . .   . .||| | || |   .| |. |||| |.|  |||||||. ..  |||| .
efsnlpgdpps.dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

LEEKQQECSFLYWS-D-LESRQFGEITIELIKKKEEIDYLHRQFKIAHleQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNvqelyITLRTTEPItV
. | ..|    |.  .     || .....      .   .  ......  . | .  . |. .  ||.  || |.  .|.....     |  |.| |. .
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..ege.trlithwlwkewpdwqvpessevmlkilrk.....irarstppv.i

MCSSGVGRTGVFIALGIVLERY-SVEGMIDLFQTVKTLRIQ-RSAMVQTrLSQKKIV
 ||.||||.| ..|. | |.   |   . |. | |  ||.  |.| ||| | |  ..
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqt.lqqymli

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 681-930 3.3e-64 211.6 In-house 26-270 (287) alignment
Range on Protein: 681-930
Range on HMM: 26-270/287.0
FQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLE
|. |     ...    .  . || |||. .|.... .|| |      |  |||||..||.|....|......|| ||. .||..|.... ..||||....
ftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

EKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG-VPVSALPLLQMIQNVQELYitLRTTEPITVMCS
|...|  . ||.. .|  .|| .|||.... . .|. |.... . .. ..  ... .|.  |...| |.  .  ||.. . ... .   |.  .| | ||
endeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr..krgntsivvhCs

SGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQKKI
 .|||...|.|  . ...   || ||.|| .|  |||.  .|||    | |
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfi

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 681-925 2.9e-53 175.6 In-house 1-251 (270) alignment
Range on Protein: 681-925
Range on HMM: 1-251/270.0
FQRLATDRTEPHRFASATKnvNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSY-RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKL
|..|  ..|... . .|..  .|  ||. .|.|    ||.|. .. .. . |||| |.  .  ....|.|..||...|...|||||||.|.. |||.|.|
fkeldkeetsesdlpeaar..gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

EEKQQECSFLYWSDLESR----QFGEITIELIKKKEEIDYLHRQFKIAhlEQPEASYTLhHFQFLGWPERGVPVSAL------PLLQMIQNVQELYITLR
||| ..    ||.    .    ..|.|..  .... |  |. .. ..   |. |    . ||..  ||..||| ..        ||.|...|..    |.
eEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeld

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
 .||. | || ||||||..||| |...  . .. .|. . .. || .| |.||.  
kaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe

subfamily_PTPN12_pd Subfamily PTPN12 682-924 1.3e-65 216.1 In-house 22-263 (290) alignment
Range on Protein: 682-924
Range on HMM: 22-263/290.0
QRLATDRTepHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEE
... ....  .. ....|..|. |||. .|.||...||.|| |. .||||||||..|    .. .|.|.|||. .|..||||||||.. .|.||. .. |
ekykaekv..ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCreve

KQQECSFLYWSDL--ESRQFGEITIELIKKKEEI-DYLHRQFKIAHLeqpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEPITVMC
 ..     ||..   |. .|||....|...|    |.| |..|. .    ..| ... |..  ||..||| || .||..|..|.||    .  .|. | |
lgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhC

SSGVGRTGVFIALGIVLERYSVE---GMIDLFQTVKTLRIQRSAMVQTR
|.||||||. ||. .| |    |     .|.|. | .|| ||.|.|||.
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk

subfamily_ptpA1_pd Subfamily ptpA1 683-896 2.1e-35 117.3 In-house 28-254 (418) alignment
Range on Protein: 683-896
Range on HMM: 28-254/418.0
RLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRqQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEK
||  .   |   .   |. |  |||. ||.| .. ||.|  |.  |||||||| |||     . ...||||. ||. |||||.|| . .|||||..  |.
rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresen

QQECSFLYWSD-LESRQ----------FGEITIELIK--KKEEIDYLHRQFKIAHlEQpeASYTLHHFQFLGWPERGVPVSALPLLQM---IQNVQELYI
 .     || . .   |          ||  ..||..  .  | . . |. ...  |    .  . ..|. |||.. .|  . |. |.   | | |.  |
crikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.eg..etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

TLR-TTEPITVMCSSGVGRTGVFIALGIVLE
       || | ||.|||||| | .  |...
pssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 684-936 7.9e-24 78.8 In-house 36-287 (310) alignment
Range on Protein: 684-936
Range on HMM: 36-287/310.0
LATDRTEPHRFASATKNVNkgKNRFVNIMPYEYNRVKLSFIRaTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQ
| ...     . . .|..   |||. ...  .  ||||   . .   ||| | |. .   . ... .|||.. |. ||||||.. ... |..| |  |. 
ldakqdssltyeaykkymh..knrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeeg

QECSFLYWSDLES-RQFGEITIELIK-KKE--EIDYLHRQFK---IAHLEQPEASYTL--HHFQFLGWPERGVPVSAlpllqMIQNVQELYITLRTtEPI
.  .  ||  |     .| | .  .    |  ||  |   |    .   |||     |     ..  ||.||||             | |   .|   | 
rpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek.....chtvpqrllaqvrh.gpc

TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLsQKKIVLSLKM
 | ||.|..|..| .|| . ...      .|. . .  |. .|   .|| | |  |.  ...
vvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtel.qyliidrvri

subfamily_CG7180_pd Subfamily CG7180 685-923 1e-56 186.8 In-house 25-275 (296) alignment
Range on Protein: 685-923
Range on HMM: 25-275/296.0
ATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ
 | | |    | . .. |..||| |...||.|||| |. .   | ||||||.|.||. ....|. |..|.|.||..|||........ .|.|||  . ..
ltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak

ECsFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHL-------EQPEA--SYTLHHFQFLGWPE-RGVPVSALPLLQMIQNVQELYITL---RTT
 .   ||      |.||| .|....|.  .   |.||. .        |...     ....||.  |.    ||.|.  |..... |. .        ..
my.psywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

EPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQT
.|. |..| |..|.||..|. . ||  . |. .|.|. |||||..|  .|..
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 687-930 7.7e-36 118.5 In-house 18-286 (297) alignment
Range on Protein: 687-930
Range on HMM: 18-286/297.0
DRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfIRATEGSDYINASYIDSY--RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ
| ...  |.|| .|    |||. .|. .. .||||   |.  ..||||| |.      ..  |. .|||...||.|||....|.  ..|||..||.|  .
deargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

ECSFLYWS--DLESRQFGEITIELIKKKE-EIDYLHRqfKIAHLEQPEASYTLHHFQFLGWPERGVP-----VS-----------ALPL-LQMIQ-----
.  . ||   . | .. |.. .| . .   | | ..      .|   . |  ..| |||.||. |||     .            |.|. | ...     
dkcapywpsvvqerlkagdvvveflsstsdefdrvil..telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftam

---NVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKI
   ... |        .. | ||.||||.|| .   ..|..   . . |    .. || ||. .||| | | ..
vflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqt.leqfel

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 687-926 8.5e-27 88.6 In-house 40-277 (305) alignment
Range on Protein: 687-926
Range on HMM: 40-277/305.0
DRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfirATEGSDYINASYIDSY-RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQE
| |.    |  . .... |||. ..   . . |||.       |||| | |.      .. ....|||. .|...|| |. ..| . |||| |  |  . 
dmtqvafnanqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl

CSFLYWSDLESRQ---FGEITIELIKKKEEIDYlHRQFKIAHLE--Q-PEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlrTTEPITVMCS
    ||      .    . | .| .     ..    . .|. |.     . . .. |.|.  ||.||||   |  |...  ..       .  || | ||
kcaqywpaaqgeklelksgivvenvsgskpmer.daeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcs

SGVGRTGVFIALGIVLERYSVEGM-IDLFQTVKTLRIQRSAMVQTRLS
.|.||||  .|.  .||. . .     . . ||.|| ||.  .|. . 
agigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvq

subfamily_eak_pd Subfamily eak 687-850 1.6e-16 54.7 In-house 36-197 (332) alignment
Range on Protein: 687-850
Range on HMM: 36-197/332.0
DRTEPHRFASATKNVNKGK-NrFVNIMPYEYNRVKLSFIRAtEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQE
|. .. .  | |. ... . |  |.|.||... |.|.  .  .   ||||| ..     | |. |  . .. |  ||.|. | ||  ||.| .  |.. |
ddyqrllsisetarleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle

CSFLYWSDLE--SRQFGEITIElikKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVS
 |  |. |      .|| . .|   .|| .     ...   |.. . .. ..|... || |  .|. 
ksdkyfpdktreelkfGildve...rkefvkrniletrllelskGnethrvlhykvfGwtettlpky

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 688-846 2.8e-17 57.1 In-house 82-234 (244) alignment
Range on Protein: 688-846
Range on HMM: 82-234/244.0
RTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQecs
| .|  .  | .  |  |||    .|...||| ||  ... |  |||||..    .   |. || |. .|  |||.|. | . ...|.|  .||...   
rpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede...

flYWSDLESRQFGE--ITIELIKKKEEIDYLHRQFKIaHLEQPEASYTLHHFQFLGWPERG
  || | |  .. |  ||. |  . |  .    ...|   .  |.  .|  ||   ||  |
..ywpdseplewyeeditvtltdrdefknikasnlei.esdmneshqaltmfqisnwpsdg

0049772 (Phosphotyrosine protein) phosphatases II 690-922 7.3e-40 133.0 In-house 34-264 (314) alignment
Range on Protein: 690-922
Range on HMM: 34-264/314.0
EPHRFASATKNVNKGKNRFVNIMPYEyNRVKLSFIRaTEGSDYINASYIDSYrqqRAYLATQGPMKNTVEDF----------WRMI--WEHKSKIIVM--
 .. .  | . .|. |||. .|.|.. |||.|..    .|||||||||.|..   ....|||||...||.||          |||.  ..... .|||  
peltilvadlflnrdknryldilpad.nrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTKLEEKQqecsflywsdlesRQFGEITIELIKkkeEIDYLHRQFkiahleqpeaSYTLHHFQFLGWPERGVPvSALPLLQ
                   |..| ...              .  . ..||.|   |. | .  |          . .  ..  . .|  ..| .   ...
devladelsrLdaAlgKtpllildgng.............neptaadlellk...eelydpelf..........erlgikylripvpDgsap.lledfde

MIQNVQELyitlRTTEPITVMCSSGVGRTGVFIALGIVLERYsveGMiDLFQTVKTLRIQRS-----AMVQ
... ..|.    .. .|. | |..|.||||.|....... ..   |. .| .... .| .|.      ...
flefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfie

subfamily_egg_pd Subfamily egg 690-925 4.9e-25 82.8 In-house 28-257 (307) alignment
Range on Protein: 690-925
Range on HMM: 28-257/307.0
EPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKqQECSFl
.   .  | .. |. | |   .   .. |||| . |     |.| | ...       .. .| |.||||.|||||... . . |||||   |  ..| . 
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.ercey.

YW--SDLESRQF--GEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFlGWPERGVPVSALPLLQMIQNVqelyitlrtTEPITVMCSSGVGRT
||  .. .| ..  | . || .| ... | | |  |.  .   .    | |.|   . . .   | | .|....|.         ..|. | .  || ..
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.........skpvvvqdilGvska

GVFIALGIVLERYsVEGMI---DLFQTVKTLRIQRSAMVQTRL
....|. | |  . . | |    . ..|. || .|   |.. |
atlvaieiallsl.lrGpitkslvlravvflrlrrrlsvesvl

0045098 (Phosphotyrosine protein) phosphatases II 691-924 1.9e-66 219.6 In-house 22-258 (278) alignment
Range on Protein: 691-924
Range on HMM: 22-258/278.0
PHRFASATKNVNKGKNRFVNIMPYEYNRVKlsfirategsDYINASYIDSYrqQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLY
| ..  | .  |. |||...|.||...|||          |||||||||.|  .....|||||...||.|||||.||.....|||||.|.|...|  . |
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHL---EQPEASYTLHHFQFLGWPERGVPVSA--LPLLQMIQNVQELYI-----------TLRTTEPI
| . .| ..|..|..|.. ..  || .| ... .|   ..   |....|...|.||. ||| .    ..|.... ..| .            .|   .|.
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVMCSSGVGRTGVFIALGIVLERYsvEGMIDLFQTVKTLRIQRSA-MVQTR
 | || ||||||...|. ..||..  || .||...||.|| ||   .||. 
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 691-776 2.5e-09 31.1 In-house 26-116 (347) alignment
Range on Protein: 691-776
Range on HMM: 26-116/347.0
PHRFASATKNVNKGKNRFVNIMPYEYNRVKLSF-----IRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVML
| .|.|.  . .  |||  .    .  || ||       || .   |||||.|     .. |. || |. .|| |||.|.   |   .| .
pskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_PTPN9_pd Subfamily PTPN9 692-924 1.2e-65 216.4 In-house 32-276 (297) alignment
Range on Protein: 692-924
Range on HMM: 32-276/297.0
HRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
 .|  . ...|  |||. ... |.  ||.|. .  .| ||||||...| |.|..|..|||||.|.||.|||||.||..  .||| |...|...     ||
GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyW

S--DLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIT------L-----RTTEPITVMC
   . .| .||..... .. .|| || .|...| . .. | | .. |||||.||. ||| ||  ||.....|.|   .             .  || | |
pleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

SSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|.|.|||| ||.| | |.|   .|..|...|||.|| ||. ..|| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtp

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 692-925 3e-59 195.5 In-house 39-266 (315) alignment
Range on Protein: 692-925
Range on HMM: 39-266/315.0
HRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
| .  | |  || |||..||..|.  ||.| ..   ..|||.||..|| | ..| |.|.|||  ..|.||||...|..   |||||.| |.... .  ||
hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

SDLeSRQFGEITIELIKKKEEIDYLHRQFKIAHLEQpeaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYiTlRTTEPITVMCSSGVGRTGVFIAL
 |     .|.||. ..... . .|  | . .   ..     ..  ...  ||. ||| ...||...|..|.    |  .  .| | ||.|||||| ||.|
pdk.kviyGkitvtrkseevnteytvrtlsvvfgdn...irevvqlhytswpdmgvpkytiplmnlirtvkqhh.t.nsvgaivvhcsaGvGrtGtfitl

GIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
  ||..  .| .||... .. .| .|  |||.  
davldqaeaenaidvynfitgvrqnrikmvqvae

subfamily_PTPN1_pd Subfamily PTPN1 692-924 1e-46 154.0 In-house 22-257 (290) alignment
Range on Protein: 692-924
Range on HMM: 22-257/290.0
HRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
.. ..| .. |...||. .. ||.. |.||      .  |||||| ..  . .| |. ||||. |||. ||.|.||.||| .||| |. ||.|   . ||
fptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

SDLES---RQFG--EITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTG
   |.    ..   .....||.....  |  |....  |.  | . .. || .. ||. ||| |   .|.....|.|     .   |  . ||.|.||.|
Pqgeeekellledtklkvkliseerksyytvrllelenlktqe.treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VFIALGIVLERYSVE---GMIDLFQTVKTLRIQRSAMVQTR
 |. .  .| .   .     .|. ...  || .|  ..|| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

subfamily_PTPRK_pd Subfamily PTPRK 694-924 6.8e-69 227.1 In-house 35-263 (314) alignment
Range on Protein: 694-924
Range on HMM: 35-263/314.0
FASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSD
. .| |. |. |||. .|..|.  ||.|  |     ||||||..||||.. .|...||||...||.||||.......  |||||.| |...     || .
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

lESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAS-YTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlrTTEPITVMCSSGVGRTGVFIALG
 .....|.| .||.. . . ....| |.. .|...     ....|||||||. .|||||  ||.....|..      .  .| | ||.| ||||.|||. 
.dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaid

IVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|||.    ||..|.|..||||| ... ||.| 
ivldmieregvvdvfnavktlrsrkvnmvete

subfamily_PTPN13_pd Subfamily PTPN13 694-924 1.4e-53 176.9 In-house 29-255 (273) alignment
Range on Protein: 694-924
Range on HMM: 29-255/273.0
FASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSdYINASYIDSY--RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
  .. |. || |||. |..||.  ||||.     ||. |||||.|      ..  |.|.|||. .||.|||.|.|| |...|.|.|.  ||..     ||
cevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

SDLESRQF---GEITIELIKKKEEIDYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlrTTEPITVMCSSGVGRTGVF
 . ....    . ...||.| ..  ..  |.... ..|  ..|  . |..|  ||. ||| ||..|||....|..|      . || | ||.|.||.|..
Pesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtl

IALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|.. .||.  . .  .|. ..|..|| || ..|||.
itidvvlglierdkefdvkeivrklreqrqgvvqtk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 695-932 2.9e-51 169.0 In-house 26-259 (283) alignment
Range on Protein: 695-932
Range on HMM: 26-259/283.0
ASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAtegsDYINASYID---SYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
  |. . || |||. .|.|.. .||.|         |||||..|    ||.|.. |...|.|...|| |||.|....|   ||||||| | ...    ||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

SDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG--VPVSALPLLQMIQNVQelyiTLRTTEPITVMCSSGVGRTGVFI
    | ..|| |. | |   .  .  ... . .    ...  | |.|. .| | |   .. .|  .  ..  |    |     || | ||.|.|||.|||
PkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislq....teskkgPivvhCstgiGrtavfi

ALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKIVL
|.   ..    | ..|.|..|| .| ||  .||| | | |.| 
aasasvkdaltesvvdvfavvkimreqrmmavqt.ldqyklvh

0040439 (Phosphotyrosine protein) phosphatases II 696-923 8.8e-69 227.1 In-house 5-231 (249) alignment
Range on Protein: 696-923
Range on HMM: 5-231/249.0
SATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE
 | . .|| |||...|.||...||||| ..  ..|||||||||| |...|...|||||...||||||||.||.....|||||.|.|...|  . ||.. .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SRQFGEITIELIKKKEEIDYLHRQFKIAHLeQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVL
| ..|..|..|.. ... || .|.... .| .   |.| .|.|...||. ||| |  .||..|. |.. . .|.. .|. |.|| ||||||.|||. ..|
sleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERYSVEGMIDLFQTVKTLRIQRSAMVQT
|..  |. .||...||.|| ||. .||.
eqlekelgvdleeavkllrsqRpgavqn

0037934 (Phosphotyrosine protein) phosphatases II 696-924 6e-62 204.7 In-house 4-228 (243) alignment
Range on Protein: 696-924
Range on HMM: 4-228/243.0
SATKNVNKGKNRFVNIMPYEYNRVKLsfiratEGSDYINASYIDSYRQqraYLATQGPMKNTVED----FWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
 | . .|. |||. .|.||...||||      ||||||||..|. ...   . |||||...||||    ||||.||.....|||||.|.|...|  . ||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

SdlESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIT------LRTTEPITVMCSSGVGRT
.  .. ..|..|..|.. ..  || .| ... .|. .. ... .|...|.||. ||| |  .||.... |.| .        | . .|. |.|| |||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFIALGIVLERYsveGmIDLFQTVKTLRIQRSA-MVQTR
|..||. ..|...   | .||...||.|| ||.  .|||.
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtp

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 696-925 5.9e-47 154.8 In-house 2-228 (239) alignment
Range on Protein: 696-925
Range on HMM: 2-228/239.0
SATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYR-QQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL
.| | ||| |||. ||. |...|| |  .     ||||||||.  |    .||.|||| .. .  |||||.|. .  .||||| | | ...  . || | 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

ESRqFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTlHHFQFLGWPERGVPVSALPLLQMIQNVQElyITLRTTEPITVMCSSGVGRTGVFIALGIV
 |. . .. . | | .   ||. | | .... | |  |  ....|  ||..|||  |  .| . ... .   .|  . |  . ||.|||||| |. .  .
tsk.ycnlrvtlrktevfadyiirtfvmsqvgqteeryv.yqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidam

LERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
| .   .  .|.|. ||..| .|  ||||  
lrqakkqktvdifnyvkairedrphmvqtse

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 697-924 8.9e-68 223.2 In-house 4-228 (250) alignment
Range on Protein: 697-924
Range on HMM: 4-228/250.0
ATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSfLYWSDLES
| |  || |||. .|....  || |   .. . |||||||....|....|..|||||...|.||||||..|.||. |||||.|.|......  ||   ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyh.qywPveka

RQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrTTEPITVMCSSGVGRTGVFIALGIVLE
...|..|..| .|.|  || .|..|... .. . . .. ...|. ||..|||  |   |.....||        . |. | ||.||||.| |||.  |||
ekyGdvtvsllskeefadytkrklklskakkad.erivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaidavle

RYSVEGMIDLFQTVKTLRIQRSAMVQTR
|   | ..|.|. .|.||..|  .|...
rlkkekvvdvfkvikvlrkdrphavesl

0042113 (Phosphotyrosine protein) phosphatases II 697-923 4.3e-66 218.1 In-house 4-228 (245) alignment
Range on Protein: 697-923
Range on HMM: 4-228/245.0
ATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES
| . .|| |||...|.||...||||| .   ..||||||||.| ||. . ..|||||...||||||||.||.....|||||..||.... .. ||.. ||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

RQFGEITIELIKKKEEIDYLHRQFKIAHlEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLE
 ..|..|..|.. . . || .|.... . ..   | . .|...|.||. ||| .   ||.... |.. .      .|. |.|| ||||||.|||. ..||
ltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmle

RYSVEGMIDLFQTVKTLRIQRSAMVQT
..  |. ..|...|| || ||. .|||
qlekelgvsleeavkelrsqRpgavqt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 697-925 7.7e-47 154.4 In-house 2-227 (239) alignment
Range on Protein: 697-925
Range on HMM: 2-227/239.0
ATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYR-QQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE
| | ||| |||. ||. |...|| |  .     ||||||||.  |    .||.|||| .. .  |||||.|. .  .||||| | | ...  . || |  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SRqFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTlHHFQFLGWPERGVPVSALPLLQMIQNVQElyITLRTTEPITVMCSSGVGRTGVFIALGIVL
|. . .. . | | .   ||. | | .... | |  |  ....|  ||..|||  |  .| . ... .   .|  . |  . ||.|||||| |. .  .|
sk.ycnlrvtlrktevfadyiirtfvmsqvgqteeryv.yqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidaml

ERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
 .   .  .|.|. ||..| .|  ||||  
rqakkqktvdifnyvkairedrphmvqtse

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 697-926 4.8e-26 86.4 In-house 30-258 (285) alignment
Range on Protein: 697-926
Range on HMM: 30-258/285.0
ATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDS-YRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ-ECSFLYWSDL
.. . |   ||. ..   |  || |         ||| ||..    ..| .|..||||. .|. |||.||.. |   ..||  | |    .|.. |   |
tayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

-ESRQFGEITIELIKKKEEI--DYLHRQFKIAHLEQPEA-SYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYitlRTTEPITVMCSSGVGRTGVFIA
 |  .||.  | | . |||     .   . .   |.  .    . | |   ||..  |  | |.... . |...       .|| | ||.|||||  |. 
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagvgrtatfvg

LGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLS
.     |   .  |.... |. .|  |   ||... 
idyatirimenpniemldivremramrfqavqshmq

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 698-924 7.8e-25 82.2 In-house 44-273 (305) alignment
Range on Protein: 698-924
Range on HMM: 44-273/305.0
TKNVNKGKNRFVNIMPYEYNRVKLsfiRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW--SDLE
 .  ..||||. ..   . |||||   ...   .|| | |. .  . . .. || |...|  ||| | ...| . | || .| ||  .  . |.   | .
keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

SRQFGEITIELIKKKEEIDYL-HRQFKIA-------HLEQP-EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlrTTEPITVMCSSGVGRTG
  .| |    .. | |    |  |.   |        .| | | .    |. .  ||.|||| . | .|..... .       .  ||.| ||.|.||||
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp......skgpivvhcsagigrtg

VFIALGIVLERYSVEGMIDLFQ-TVKTLRIQRSAMVQTR
  . |  .|..     .|.  .  .. .| ||   .|| 
svvmleyildqllagqiiedtdkilqkireqrnnsiqtd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 698-806 2e-14 47.7 In-house 43-165 (349) alignment
Range on Protein: 698-806
Range on HMM: 43-165/349.0
TKNVNK-GKNRFVNIMPYEYNRVKLSF-------IRA-------TEGSDYINASYIDS--YRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLE
.. |.   |||. .|.|||. ||||         |.|       .   ||||| |.    .  .. |.||| |.  ||.||...|   . |... |.. .
seGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddk

EKQQECSFLYWSDLEsrqFGEITIEL
|.. |    || .|.   . .||. |
elslekcdiywqels...ysnitvkl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 698-784 4.9e-08 26.1 In-house 23-82 (169) alignment
Range on Protein: 698-784
Range on HMM: 23-82/169.0
TKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINAsyidsyrqqraylatqgpmkntvedfwRMIWEHKSKIIVMLTKLEEKQQ
   .|. |||    .   . ||||  .    |||||||                           |||||  . .||.|   ..|..
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknn

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 698-784 7.5e-08 25.4 In-house 22-81 (169) alignment
Range on Protein: 698-784
Range on HMM: 22-81/169.0
TKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINAsyidsyrqqraylatqgpmkntvedfwRMIWEHKSKIIVMLTKLEEKQQ
   .|. |||    .   . ||||  .    |||||||                           |||||  . .||.|   ..|..
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknn

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 699-925 1.5e-33 110.7 In-house 53-270 (290) alignment
Range on Protein: 699-925
Range on HMM: 53-270/290.0
KNVNKGKNRFVNIMPYEYNRVKLSfirATEGSDYINASYIDSYRqqRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES--
|| .  |||. ...  .  || |.        ||. | |..  .    .. |||..|.|| |.|||. ..|   |||| .| |. .     |. . |   
kntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

RQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQelyitlRTTEPITVMCSSGVGRTGVFIALGIVLE
  |||||.   ..... . . ..       .   .. |.|..   ||.. |. |.| ||.... ..      ... |..| ||.|.|||| |.|. . |.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr......kasGpvvvhcsaGiGrtGtfvaievglq

RYSVEGMIDLFQTVKTLRIQRSAMVQTRL
       .|| ..|..||  | . ||  .
illdGkeldlldlvralrnsrlnsvqvdi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 700-812 1.4e-25 84.7 In-house 44-168 (350) alignment
Range on Protein: 700-812
Range on HMM: 44-168/350.0
NVNK-GKNRFVNIMPYEYNRVKLS--------FIRATEGSDYINASYIDSY----RQQRA--YLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ
 |.   |||..||.||| .||||            .....|||||.|.       ...    |.|||.|...||.||...| . | |.|..||.. | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

ECSFLYWSDLEsrqFGEITIELIKKKEE
|    || ...   . .||. |  |.|.
ekcyrYWqegs...ydditvklaskwen

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 701-934 4.2e-20 66.5 In-house 46-274 (303) alignment
Range on Protein: 701-934
Range on HMM: 46-274/303.0
VNKGKNRFVNIMPYEYNRVKLSfirateGSDYINASYIDSYRQQRAYLaTQGPMKNTVEDFWRMIWEHKSKII-VMLTKLEEKQQECSFLYWSDLESRQF
 |  |||||...  .. .||||       | || |||..   ...| | || |.  |  |||.|| | | | . ..||  | ..    ...  . .  .|
knmdknrfvdvicldhskvkls......dssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GEITIELIKKK-EEIDYlHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALP-LLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGI-VLE
 | .| . . |  |.     ..|.  . . .    ||  ..  ||   .|  . | ... | ..| .      ..|   |  ||.||.| |  .    | 
eersirvgefkrvelgd.gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

RYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKIVLSL
 .| .  .|| . ....|  |   ||  |||  .| .|
lhseqasldlvkclenvrngrlhavqn.lsqfsvvytl

Y_phosphatase Protein-tyrosine phosphatase 702-923 7.4e-71 233.6 Pfam-A 1-222 (235) alignment
Range on Protein: 702-923
Range on HMM: 1-222/235.0
NKGKNRFVNIMPYEYNRVKLsfiRATEG-SDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWS--DLESRQ
|| |||. .|.||. .||||   . .|| ||||||.|...|.......|||||.|.|.||||||.|..|.|.|||||.||||..|    ||.  . || .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGEITIELI-KKK-EEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYitLRTTEPITVMCSSGVGRTGVFIALGIVLE
.|.|..||  |.| .| .|  |.... . ...... ....... .||..||| |. .||..|..|..      ...|..|.|| ||||||.|.|| |.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RYSVEGMIDLFQTVKTLRIQRSAMVQT
. . |. .|..|.||.|| ||  |||.
qleaeeevdvlqivkelRkqRpgmvqs

Y_phosphatase Protein-tyrosine phosphatase 702-923 7.4e-71 233.6 In-house 1-222 (235) alignment
Range on Protein: 702-923
Range on HMM: 1-222/235.0
NKGKNRFVNIMPYEYNRVKLsfiRATEG-SDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWS--DLESRQ
|| |||. .|.||. .||||   . .|| ||||||.|...|.......|||||.|.|.||||||.|..|.|.|||||.||||..|    ||.  . || .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGEITIELI-KKK-EEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYitLRTTEPITVMCSSGVGRTGVFIALGIVLE
.|.|..||  |.| .| .|  |.... . ...... ....... .||..||| |. .||..|..|..      ...|..|.|| ||||||.|.|| |.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RYSVEGMIDLFQTVKTLRIQRSAMVQT
. . |. .|..|.||.|| ||  |||.
qleaeeevdvlqivkelRkqRpgmvqs

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 702-930 3.1e-58 192.0 In-house 28-259 (274) alignment
Range on Protein: 702-930
Range on HMM: 28-259/274.0
NKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYIDSYRQ-QRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESR--
.. |||. .|.| |  || |.   .. | |.|||| ||  |.. ..||.|||||. |||.||||||.......|||||||.|....    |. | |.   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--QFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAsytLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTT-EPITVMCSSGVGRTGVFIALGIV
  ..|.. |.  |..|. ||  |.. . .||..     ..|. .  ||.. .| .| .||.....|.|   .  .   |. | ||.|.||||.|||  | 
serygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKI
. .   |...|....|  ||..|  ||||. .| ..
vrqlreeivvdvlkivcnlrldrGGmvqts.eqyel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 702-924 1.8e-46 153.3 In-house 3-225 (237) alignment
Range on Protein: 702-924
Range on HMM: 3-225/237.0
NKGKNRFVNIMPYEYNRVKLSfiRATEGSDYINASYIDSYRQ-QRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES-RQF
|| |||. ||. |...|| |    |  |||||||.|....    . |.|.|||.... .|||.|.|. |  .||||| | |....    || . .  . .
nkiknrygnivaydhsrvvlk..gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYS
| .|. | ||.|  ||  | . ...  . .    .| .||  ||.||||  .  ||.. .|. .    .  . |  . ||.||||||.|. .  .| .  
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

VEGMIDLFQTVKTLRIQRSAMVQTR
 . ..|... |...  .|  ..||.
ekkvvdiynyvysieedrpyiiqtk

0041856 (Phosphotyrosine protein) phosphatases II 702-924 1.8e-40 133.8 In-house 1-157 (182) alignment
Range on Protein: 702-924
Range on HMM: 1-157/182.0
NKGKNRFVNIMPYEYNRvklsfirateGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTkleekqqecSFLYWSDLEsrqfge
|. |||...|.||...|          ..|||||....... .. ..|||||...||.||.||..|.. ..||.||         ..||| .|.      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

itielikkkeeidylhrqfkiahleqpeaSYTLHHFQFLGWPERGVPVsALPLLQMIQNVQElyitlrTTEPITVMCSSGVGRTGVFIALGIVLERysve
                               . .....|.||  |||     ||..|. |.|        .|. | || ||||||...|. .....    
.............................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

GmIDLFQTVKTLRIQRSAMVQTR
| ..|...||..| .|. ||.| 
g.vsleeavklvrsrRpgmvitp

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 702-925 7.9e-28 92.3 In-house 43-258 (288) alignment
Range on Protein: 702-925
Range on HMM: 43-258/288.0
NKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL--ESRQF
|  ..|. |.   .. |||||     .   ||.|  . | . .|  . .| |.. |.| .|.|. |   . ||||..| || .| |  |.     |. ..
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVqelyitLRTTEPITVMCSSGVGRTGVFIALGIVLERYS
| .     ||...|| | .   .   .. | .  . .  .| |.. ||| . |. |.... .        ...|| |..| |||||| .|   |.||   
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslr

VEGMIDLFQTVKTLRIQRSAMVQTRL
..  . . . .. || .|   .||  
lddflgirsllaklreerfkaiqtem

subfamily_CG42327_pd Subfamily CG42327 702-862 1e-23 78.6 In-house 28-191 (319) alignment
Range on Protein: 702-862
Range on HMM: 28-191/319.0
NKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQR-AYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE----S
 | |.|..|..|    || |  |   . . |..|||.  |.. .  |.|.| .....  ||||..|| .|..|| ||.| |.  .    |.   |     
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

RQFGEITIELIKKKEEIDYLHRQFKIAHLEQpEASYTLHHFQFlGWPERGVPVSALPLLQMIQNVQ
. .|.| . | ... .  |.   . . .... | |  | |. .  |.| .|| .  .|. |. .|.
slyGdilvtlkgrevkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 702-788 1.7e-11 38.2 In-house 34-119 (332) alignment
Range on Protein: 702-788
Range on HMM: 34-119/332.0
NKGKNRFVNIMPYEYNRVKLSFIraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVED-FWRMIWEHKSKIIVMLTKLEEKQQECSF
|   ||   .  ....||.|.        |. |||..| | .. ||. .| |...  |  ||||. |.|  .|...  ..|||.  . 
nmdmnriphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 703-892 1.4e-17 58.3 In-house 44-230 (312) alignment
Range on Protein: 703-892
Range on HMM: 44-230/312.0
KGKNRFVNIMPYEYNRvklsFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL------E-
|  ||. ||  ..  |    |  | .   || | ..    .   ...||||..||.  ||..     |  |..|. . |   | .  | ||.      | 
kdlnrypniqcwdrgr....ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

SRQFGEITIEL-IKKKEEIDYLHRQFKIAHLEQPEASyTLHHFQFLGWPERGVPVSALPLLQMIQNVQelyitlRTTEPITVMCSSGVGRTGVFIALG
 | . |   |. |  |      || .|.      . |  | |.|.  ||. |.| |    |...  |.      .   |.   ||.|||||| .. . 
hrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlalie

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 712-846 5.9e-14 46.5 In-house 3-125 (130) alignment
Range on Protein: 712-846
Range on HMM: 3-125/130.0
MPYEYNRVKlsfirateGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQecsflYWSDLESRQFGEITIEL-IKKK
...|..|..        | .|||||..    . . || || |. .|  |||.|. |    ..|.|  .||...     || | |  .. |  | . . ..
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdr

EEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG
.| .... ..   . .  |.  .|  ||   ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg

0044763 (Phosphotyrosine protein) phosphatases II 713-927 2e-26 88.2 In-house 1-160 (178) alignment
Range on Protein: 713-927
Range on HMM: 1-160/178.0
PYEYNRVKLSFIRATEGSDYINASYIDSYrqqrAYLATQGPmkntvEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESrqfgeitielikkkee
|.. .||.|| .. .|.|||||||.|. .     ||....|     .|......|.. . ||.||.  |  .. .. || . ..                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

idylhrqfkiahleqpeasytlHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEPITVMCSSGVGRTGVFIALGIVLERysveGMiDLFQTVKT
                       .......|  ||| .   .|.... ..|..   .  .|. | || ||||.|...|. .....    |. .|.. .. 
......................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRIQRSaMVQTRLSQ
.| .|. .|...  .
vrerRp.ivpnpgql

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 715-924 4.1e-18 60.5 In-house 31-245 (290) alignment
Range on Protein: 715-924
Range on HMM: 31-245/290.0
EYNRVKLSFIRATEGSDYINASYIDsYRQQRAYLATQGPMKN-------TVEDFWRMIWEHKSKIIVMLTKLEEKQQE-----CSFLYWSDL-ESRQFGE
| .|| |        .||| |...  . .  . ..|| | ..       |.|.|| |. . |.| .||| . |||...     |.  .     |. .|. 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

ITIELIKKKEEIDYLHRQFKIAHLEQPEasYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlrTTEPITVMCSSGVGRTGVFIALGIVLERYS-V
.|..  .| .| |  .|.  . . .. |  .|. | .. || .. |. . . ||..||.|.        . |. | |  |. |  .. |. .        
ltvkCkskekeddvetRelvvkfddeee..ftvtHsllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilgyQkiaet

EGMIDLFQTVKTLRIQRSAMVQTR
.| . | . .|.|| ||  .... 
sgsvkledvlkalrkqralaitsa

0043147 (Phosphotyrosine protein) phosphatases II 728-924 4e-36 119.7 In-house 3-147 (172) alignment
Range on Protein: 728-924
Range on HMM: 3-147/172.0
EGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLeekqqecsflywsdlesrqfgeitielikkkeeidylhrqfkiaHLEQ
||||||||||.| |.  . ..|||||. ||..|||||..|.. ..||.||.|                                             .  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

PEASYTLHHFQFLGWPERGVPvSALPLLQMIQNVQELYiTLRTTEPITVMCSSGVGRTGVFIALGIVLerysvEGMiDLFQTVKTLRIQRSAMVQTR
.  . .  ....|.||  ||| ..  ||.... ..||.  |.  .|. | || ||||||...|. ..|     .|. .|...|...| .|. .||. 
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnp

0046846 (Phosphotyrosine protein) phosphatases II 728-924 3e-31 103.9 In-house 10-159 (176) alignment
Range on Protein: 728-924
Range on HMM: 10-159/176.0
EGSDYINASYIDSYRqqraYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFgeitielikkkeeidylhrqfkiahleq
...|||||..|...|    ..|||||. .|..||..|..|.. ...|.||.. |...   . ||..||. ..                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

peasytlhHFQFLGWPERGVPVSalplLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLErysvEGMIDLFQTVKTLRIQRS-AMVQTR
        ....|.||. ||| .     .... .....  |.  .|. | || |.||||...|. ..      |  ..........| ||.  .|||.
........qylhlpwpDhgvpdl....elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtp

0051429 (Phosphotyrosine protein) phosphatases II 729-925 6.3e-43 142.7 In-house 3-212 (272) alignment
Range on Protein: 729-925
Range on HMM: 3-212/272.0
GSDYINASYIDSYRQ---QRAYLATQGPMKNTVEDFWRMiWEHKSKIIVMLTKLEEKQQECSFLYWS------------DLESRQFGEITIELIKKKEEI
 |.||||.... | .    .......||...|..||||. .|.. | ||.|...||....  ..||             . ..  .| ... |....   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSAlpLLQMIQNVQElyitlrtTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMID--------
||..| . . .| .........|.....|| .||| .|  ||.... ...        .|. | ||.|..|||...|| ..|.. | | ..|        
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

LFQTVKTLRIQRSAMVQTRL
|...|. || || ..|||  
leeaveelraqrpgavqtee

0036282 (Phosphotyrosine protein) phosphatases II 729-923 4.5e-36 119.5 In-house 1-155 (174) alignment
Range on Protein: 729-923
Range on HMM: 1-155/174.0
GSDYINASYIDSYRQQRAYLATQGPMKntvedFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDlesrqfgeitielikkkeeidylhrqfkiahlEQP
||||||||..| ..  . ..|.|||..     ||.|..|......|||....|.. .  . ||..                                 . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

EASYTLHHFQFLGWPERGVPVSALpLLQMIQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLERYSvEGMIDLFQTVKTLRIQRSAMVQT
  . . .....|.|| .||| ..  ||.... |.| .       |. | || ||||||...|. ..| .   |...| ...|..|| ||. ||||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

0051082 (Phosphotyrosine protein) phosphatases II 729-925 6.2e-28 92.7 In-house 2-140 (151) alignment
Range on Protein: 729-925
Range on HMM: 2-140/151.0
GSDYINASYIDSYrqqraYLATQGPMKntveDFWRMIWEHKSKIIVMLTKLEEKQqeCSFLYWSDLEsrqfgeitielikkkeeidylhrqfkiahleqp
 |||||.||....     .....||.     ||.....|.. | ||.|...|| .      |. .|.                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

easYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlRTTEPITVMCSSGVGRTGVFIALGIVLERysvegmIDLFQTVKTLRIQRSAMVQTRL
    ...|...|.||. |.|.|   .|.... ...         |. | ||.|.||||...|| ..|..      ..|..... .|..|  .||.  
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 733-924 4.2e-29 96.2 In-house 78-267 (301) alignment
Range on Protein: 733-924
Range on HMM: 78-267/301.0
INASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES--RQFGEITIELIKKKEEI--DYLHRQFKIAHLEQP
| | .|..  . . ..|||||.||| |||| |.  .. . ||||..  ||..|    | .   |   . |  .|.. .|.  .  .  .|.....   . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQelyitlRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 |. |. |.|.  |..|||| |   | .... |.      .. .|| | ||.|.||.  ||.  ..  .   .  |.| ...| || .|   |||.
fatrtvthyqysewtdrgvPkshaelfdlmelvk......ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn

0049260 (Phosphotyrosine protein) phosphatases II 737-924 8e-32 105.4 In-house 1-136 (152) alignment
Range on Protein: 737-924
Range on HMM: 1-136/152.0
YIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWsdlesrqfgeitielikkkeeidylhrqfkiahleqpeasytlhH
.|| |.......|||||. ||..|||||..|.. ..|||||.|.|.  ..   |.                                            .
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FQFLGWPERGVPVSALPLLQMIQNVQELyiTLRTTEPITVMCSSGVGRTGVFIALGIVLerysveGMIDLFQTVKTLRIQRSAMVQTR
...| ||  ||| ..  ||.... ...|   |.  .|. | || ||||||...|. ..|        ..|...|. .| .|. .|.. 
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 739-805 5.1e-10 33.3 In-house 230-294 (440) alignment
Range on Protein: 739-805
Range on HMM: 230-294/440.0
DSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQqeCSFLYWSDLESRQFGEITIE
. | .. |..||| |.  || ||||.. ...   |.|| .|..|   ||  .  .  |  || .|. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt..csiywpvntrsvtfgpftvg

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 742-922 5e-24 79.6 In-house 2-188 (199) alignment
Range on Protein: 742-922
Range on HMM: 2-188/199.0
RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKlEEKQQE-CSFLYWSDLESR--QFGEITIELIKKKEEIDYLHRQFKI-AHLEQPEASYTLHHF
. || |.||| |...|. |||.|.||  |  |||.   ..|..|    .||.  ||   ..| ...       . ||    . .      | ..  . |.
kgqrryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QFLGWPERGVPVSALPLLQM--IQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLE--RYSVEGMIDLFQTVKTLRIQRSAMVQ
||  | |.  |  || .  .   ..|   |       |. | || | | ||||.|| | .     |   ..|||.  | ||  |  .. 
qftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 743-922 6.9e-24 79.1 In-house 2-187 (198) alignment
Range on Protein: 743-922
Range on HMM: 2-187/198.0
QQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKlEEKQQE-CSFLYWSDLESR--QFGEITIELIKKKEEIDYLHRQFKI-AHLEQPEASYTLHHFQ
 || |.||| |...|. |||.|.||  |  |||.   ..|..|    .||.  ||   ..| ...       . ||    . .      | ..  . |.|
gqrryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FLGWPERGVPVSALPLLQM--IQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLE--RYSVEGMIDLFQTVKTLRIQRSAMVQ
|  | |.  |  || .  .   ..|   |       |. | || | | ||||.|| | .     |   ..|||.  | ||  |  .. 
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 751-925 2.3e-17 57.4 In-house 97-275 (302) alignment
Range on Protein: 751-925
Range on HMM: 97-275/302.0
QGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEIDYL--HRQFKIAHLEQ------PEASYTLHHFQFL
  | |.|.| .| .| ...  |.| |... |....    |.||   .  .||. |.. .. |.... .   ..||.  .|        .  .|.. ..| 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWPERGVPVSALPLLQMIQNVqELYitlRTtePITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
.||. | |  | . |....   | |   ..   . | || |||||| ..|.   ..  | . . || . |. .|  |   ||.  
awpdhGapkeaytaldilkfc.esy...kk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 753-943 8.8e-16 52.7 In-house 39-217 (255) alignment
Range on Protein: 753-943
Range on HMM: 39-217/255.0
PmknTVEDFWRMIWEHKSKIIVMLTKLEE-KQQECSFLYWSDLESR-QFGEITIELIKkkEEIDYLHRQFKI-AHLEQPEASYTLHHFQFLGWPERGVPV
    ||. |...|   |.. .|||. ..| ....||  .  ... . .. ....   |     | . |  .| ..| .     |..|... ||.|.  | 
l...tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

SAlpllqmiQNVQELYITLRTTEPITVMCSSGVGRTGVFIalgivLERYSVEGMIDLFQTVKTLRIQRSAMV-QTRLSQKK-IVLSLKMTYSFFTL
 |       .......   | . .. |.||.|.||.  |.     |  .    ||  ..| .|  ..   .. ..| ..|. |   |....|....
la.......reilnilkvvrdsksvvvhCstGiGrsaafv.....laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv

subfamily_hpo-7_pd Subfamily hpo-7 754-943 1.5e-13 45.2 In-house 43-223 (263) alignment
Range on Protein: 754-943
Range on HMM: 43-223/263.0
MKNTVEDFWRMIWEHKSKIIVMLTKLEEK-QQECSFLYWSDLESR-QFGEITIELIKKKEeiDYLHRQFKIAH-LEQPEASYTLHHFQFLGWPERGVPVS
. .|.. |...|   |.. .|||.  .|. ...||  .  ... . .. ....   | ..  | | .  ..   |..     |..|... ||.|.  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

ALPLLQMIQNVqelyitlRTTEPITVMCSSGVGRTGVFIALGIVLERysvegMIDLFQTVKTLRIQR-SAMVQTRLSQKK-IVLSLKMTYSFFTL
|   |.... .       |   .. |.||.|.||.  |    .|  .     ||  ..| .|  ..  | . ..| |.|. |   ... .|....
areilnilkva.......rnskslvvhcstGiGrsaafsvaElvyqk.....mirsldttstveldylsLleelrssrkraihtPmqLafsilmv

0048076 (Phosphotyrosine protein) phosphatases II 824-924 3.2e-14 48.3 In-house 37-129 (145) alignment
Range on Protein: 824-924
Range on HMM: 37-129/145.0
HLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyiTLRTTEPITVMCSSGVGRTGVFIALGIVLErysvEGmIDLFQTVKTLRIQRSAMVQT
  |..  . .  ....|.|| .||| ..  ||.... ..|    |.  .|. | || ||||||...|. ..|.    .| ..|..... .| ||. .|..
tselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpn

R
 
p

0048179 (Phosphotyrosine protein) phosphatases II 829-924 6.7e-14 47.3 In-house 44-131 (144) alignment
Range on Protein: 829-924
Range on HMM: 44-131/144.0
EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELyitLRTTEPITVMCSSGVGRTGVFIALGIVLerysVEGmIDLFQTVKTLRIQRSAMVQTR
.   . .....|.|| .||| ..  ||.... ..|.   |.  .|. | || ||||||...|. ...    ..| ..|..... .| .|. .|...
fleregiqylhlpwpDhgvpdllellleflefieea...leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 830-924 1.3e-16 55.0 In-house 87-180 (440) alignment
Range on Protein: 830-924
Range on HMM: 87-180/440.0
ASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 | ||..... |||..|||  | |.|.|||.|.|         |. | ||.|.||||| ||.  .|        ||.|  ....| .|  |||| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 830-897 5.2e-06 20.0 In-house 216-291 (349) alignment
Range on Protein: 830-897
Range on HMM: 216-291/349.0
ASYTLHHFQFLGWPERGVPVSALPLLQMIQ--------NVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLER
  | |  .|.  |.. .. .    .|| ..        .  .||.    . .. | ||.| |||||.. | ..|. 
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 831-923 6.5e-10 33.2 In-house 214-329 (350) alignment
Range on Protein: 831-923
Range on HMM: 214-329/350.0
SYTLHHFQFLGWPERGV---PVSALPLLQ----MI-QNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGM--------------ID-LF
 | ....|.  |.. ..   | | |. |.    .| ... |...    ..|| | ||.||||||....|  .|. . .  .               | ..
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

QTVKTLRIQRSAMVQT
..|. || ||  |||.
iivnelrkqrismvqn

PTPc_DSPc_SM00012 833-924 1.2e-23 78.7 In-house 1-93 (105) alignment
Range on Protein: 833-924
Range on HMM: 1-93/105.0
TLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVE-GMIDLFQTVKTLRIQRSAMVQTR
|..|....|||. ||| .. ..|.....|.. .    ...|. |.|| ||||||.|.|| |.|.. . | . .|.||.|| || ||. |||| 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_CG42327_pd Subfamily CG42327 871-934 1.8e-08 28.4 In-house 247-310 (319) alignment
Range on Protein: 871-934
Range on HMM: 247-310/319.0
TEPITVMCSSGVGRTGVFIALGIVLERYSVE-GMIDLFQTVKTLRIQRSAMVQTRlSQKKIVLSL
  |..| || ||||||. ||  | ...       .|. |.|  .| .|.  |.|.  | . .   
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk.eqyefiykv

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 875-922 3.1e-09 31.1 In-house 2-49 (69) alignment
Range on Protein: 875-922
Range on HMM: 2-49/69.0
TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQ
 | |||| |||| |||. . . |   | ..|.|  |. .|  |  || 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvm

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 876-922 3.8e-09 30.8 In-house 2-48 (69) alignment
Range on Protein: 876-922
Range on HMM: 2-48/69.0
VMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQ
| |||| |||| |||. . . |   | ..|.|  |. .|  |  || 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvm