Gene PTPRD-21 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP075_AA protein Get Run
AqueP075_AA_1-147 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-145 7e-51 167.8 In-house 132-273 (290) alignment 
Range on Protein: 2-145
Range on HMM: 132-273/290.0
VCHQYWPNGPTAAvFNYISVKLINEVQESgSIIRRTFGIKDMNS-GYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGsNRPIVVHCSDSIT
.|.||||. .|.| ....|.||.|| . . ..|.|.. .|..|| |....|.|.|.||| ..|...|..||  ... ....||..| |..|||||||...
kCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvg

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQCMP
|||..|.....|...| |.. |.||..|..|.|.|| . ..|.. 
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-139 1.4e-30 101.3 In-house 127-262 (287) alignment 
Range on Protein: 2-139
Range on HMM: 127-262/287.0
VCHQYWPNGPTaAVFNYISVKLINEVQESGsIIRRTFGIKDMN-SGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGsNRPIVVHCSDSIT
||.||||.. .  |.   ...|.|| ...|  | |.. .|  | .|   .|.| |.|||   |. ... ||  .      .||..| | .|||||||.. 
vcyqyWpeeks.vvlGeyniellneevnag.yierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsivvhCsdtvG

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIP
||||.|    .|...| | . |.||..|  |.|.|| . 
rsamfcaaattinkckteGviDvfqvlksqriqkpgsvq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-141 7.5e-28 92.5 In-house 130-269 (305) alignment 
Range on Protein: 2-141
Range on HMM: 130-269/305.0
VCHQYWPNGPTA-AVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSgSNRPIVVHCSDSIT
 |.||||.  |    |. .||.| .| . |. |.|.    .. ..    ||.|.|||.|  .|     ... .|.  |. .|...  . |..||||... 
kCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd.kgvpllVhCsagvg

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
|. .... . |.|..| |.  |.|...|.|| .|.. . ..
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
0046845 (Phosphotyrosine protein) phosphatases II 2-141 9.6e-28 92.8 In-house 118-260 (284) alignment 
Range on Protein: 2-141
Range on HMM: 118-260/284.0
VCHQYWPNGPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMN-SGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSIT
 |.||||.  .  ... ..|.|..| .  .....||. ..... .|.  || ... |.|  .| ... . . ... || . ....... |||||||. . 
kcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RSAMYCVTHNAIEQAKLEQ---GSDLFQIVKTLRMQRPGGIPSQ
|...... . ..|| . |.   | |....|| ||.|||| . . 
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0045450 (Phosphotyrosine protein) phosphatases II 2-142 5.1e-25 84.3 In-house 148-291 (307) alignment 
Range on Protein: 2-142
Range on HMM: 148-291/307.0
VCHQYWPNGPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDM-NSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSIT
 |.||||.  .  ... . |.|..| .  .....||. ..|.  .|.  || ... |.|  .| . . ... |.. .| . ....... |..||||. . 
kcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RSAMYCVTHNAIEQAKLEQG---SDLFQIVKTLRMQRPGGIPSQQ
|......   ...| . |.     ||...||.||.||||......
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-141 1.8e-22 74.8 In-house 92-228 (250) alignment 
Range on Protein: 2-141
Range on HMM: 92-228/250.0
VCHQYWPNGpTAAVFNYISVKLINEvQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGsNRPIVVHCSDSITR
..|||||   .|  .  . |.| .. .| . .. |.. .   .     .|.||. ..|   |  ... .. .|   |  .|...| |.|..|.||  ..|
tyhqywPve.kaekyGdvtvsllsk.eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgr

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
|  ... .  .|..| |.  |.|...|.|| .||. . |.
sGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-136 1.1e-18 62.3 In-house 132-264 (319) alignment 
Range on Protein: 2-136
Range on HMM: 132-264/319.0
VCHQYWPNGPTaAVFNYISVKLINEVQESGSIIRrTFGIKDMNSGY-CSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSgSNRPIVVHCSDSIT
 ...|||.     ..  . |.| .| . .. |||  . ..  .|   . .|.. | |.|  ..   .  .. ||.  .   .... ...|||||||. . 
klkkywpeenf.eeyGrlivtleeeeeledyiir.klklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.qsgPivvhCsaGvG

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
|   ..| . ..|. |.|.  |.|..|..||.||. 
RtGtfivldamlervkeegvlDvfstvsrlRtqRni
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-139 2.3e-18 61.1 In-house 116-250 (283) alignment 
Range on Protein: 2-139
Range on HMM: 116-250/283.0
VCHQYWPNGPTAAvFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCST-VVQLQLTNWlpdGQCANYSTIGDL--YALVTDNQRRSgSNRPIVVHCSDS
 | ||||.  .   .    | | .|.  | | |.. . ..  .|   .  .   |. .|    .. . . |  |  . .|  .|..|  . |||||||  
kCsqyWPkrGsed.yGeftvtlrkett.snsfiikelllrvnssakstlllahyqvidW...leygeqaiinslvkfnkvislqtes.kkgPivvhCstg

ITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIP
| |.|...    ....|. |   |.|..|| .| ||.. . 
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-135 3.7e-17 57.1 In-house 128-257 (315) alignment 
Range on Protein: 2-135
Range on HMM: 128-257/315.0
VCHQYWPN-GPTAAVFNYISVKLINEVQESGSIIRRTfGIKdmNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNqrRSGSNRPIVVHCSDSIT
 | ||||.    .. |  |.|.|..  . .. ..|.  ...  .|    || | |.|.|   |   . |..  |   |  .  .   . ...||||  . 
kcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtr..kseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvG

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
|. . .  .. ..|.| ..  |.|..||.|| .||
rtGvvisidevvaqikrtrsvdvfnfvknlrakrp
subfamily_PTPRK_pd Subfamily PTPRK 2-135 5.9e-17 56.5 In-house 127-257 (314) alignment 
Range on Protein: 2-135
Range on HMM: 127-257/314.0
VCHQYWPNGPTAavFNYISVKLINEvQESGSIIRRTFGIKDMNSGYC--STVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRsgSNRPIVVHCSDSI
 | .|||.  .   .. | |.|..  .    .. |.| .. .. |.    .| |.| ..|   .   .  .. .| . |   |    .. .||||||   
kClkyWPedtev..ygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGa

TRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
 |. .... .  .. .. |.  |.|..||||| ...
GrtGtfiaidivldmieregvvdvfnavktlrsrkv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-134 1.2e-15 52.4 In-house 125-255 (281) alignment 
Range on Protein: 2-134
Range on HMM: 125-255/281.0
VCHQYWPNGPTAAVFNYISVKLINEVQeSGSIIRRTFGIkDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSgSNRPIVVHCSDSITR
 ||.|||.. ..  .  . || ..| . . . |.|.| . ...||   .|.||. |.|   |  |. . . .  . |.  .... .. |.|.|||  . |
kChrYWPddnselkygdvtvkstaeee.katyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk.tkaplvihCsaGvGr

SAMYCVTHNAIEQAKLE-QGSDLFQIVKTLRMQR
.  |     ...... | .  |. ..|. || .|
tGtyialDrlvkaveaeleeldvkavvaelrker
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-136 8.7e-15 49.4 In-house 133-260 (315) alignment 
Range on Protein: 2-136
Range on HMM: 133-260/315.0
VCHQYWPNGptAAVFNYISVKLINEVQESgSIIRRTFGIkdMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVtdNQRRSGSNRPIVVHCSDSITR
 . .|||.     ..  |.| ...| ...  .  ||. .  .      .||||..| |   | ..   .. .|.  |  .| .  |  .||||||. . |
kaekywpdk..kviyGkitvtrkseevnt.eytvrtlsv..vfgdnirevvqlhytswpdmgvpkytiplmnlirtv..kqhhtnsvgaivvhcsaGvGr

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
.  ..     ..||. |.  |...... .| .| .
tGtfitldavldqaeaenaidvynfitgvrqnrik
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-135 1.2e-12 42.8 In-house 139-271 (319) alignment 
Range on Protein: 2-135
Range on HMM: 139-271/319.0
VCHQYWPNGPTAAVF-NYISVKLINEVQEsgsIIRRTFGIKD-MNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSI
 | ||||.          ..|....| .|    . | . . .  .      . |  .  |   |.    | .  |   |.  ...   ...||||||  .
kcsqywplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGv

TRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
 |. .| | .  ... | |.  |....|. || ||.
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-135 1.3e-12 42.8 In-house 103-235 (284) alignment 
Range on Protein: 2-135
Range on HMM: 103-235/284.0
VCHQYWPNGPTAAVF-NYISVKLINEVQEsgsIIRRTFGIKD-MNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSI
 | ||||.          ..|....| .|    . | . . .  .     .. |  .  |   |.    | .  |   |.  ...   ...||||||  .
kcsqywplkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

TRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
 |. .| | .  ... | |.  |....|. || ||.
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrn
0047943 (Phosphotyrosine protein) phosphatases II 3-142 1.5e-28 95.4 In-house 119-259 (273) alignment 
Range on Protein: 3-142
Range on HMM: 119-259/273.0
CHQYWPNGPT--AAVFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSIT
|.||||.       ... ..|.|..| .  .... ||. ......|.. || ... |.|  .| ..... . ... || . .. . || |.|||||. . 
caqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQ
|...... . ...| . |.| |....|| ||.||||.... .
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0040438 (Phosphotyrosine protein) phosphatases II 3-142 3.3e-28 94.3 In-house 128-263 (317) alignment 
Range on Protein: 3-142
Range on HMM: 128-263/317.0
CHQYWPNgPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRrsGSNRPIVVHCSDSITRS
|.||||.  .  ... ..|.|..|..  ..|. ||. ..|...... || ... |.|  .|   . ... |.  .| ....  ... |..||||. . |.
caqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQ
.....   ..|| . |.| |....||.||.||||.... .
GtfiaaylmleqlekeggvdveeavkelreqRpgavqtpe
0036941 (Phosphotyrosine protein) phosphatases II 3-141 5.6e-28 93.5 In-house 120-263 (297) alignment 
Range on Protein: 3-141
Range on HMM: 120-263/297.0
CHQYWPNG-PTAAVFNYISVKLINEVQ-ESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSIT
|.||||.  .   ... ..|.|... . .......||. ..|...|.  || ... |.|  .|   ..... |.. || . .. . |. |..||||. . 
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSAMYCVTHNAIEQAK---LEQGSDLFQIVKTLRMQRPGGIPSQ
||.....   ...| .    |.| |....||.||.|||| ... 
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0039614 (Phosphotyrosine protein) phosphatases II 3-141 9.3e-28 93.0 In-house 142-275 (297) alignment 
Range on Protein: 3-141
Range on HMM: 142-275/297.0
CHQYWPNGPTaaVFNYISVKLINEVQeSGSIIRRTFGIKDmnSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSITRS
|.||||.  .  ... ..|.|... .  . ...||. ...  .|.  || ..| |.|  .| . . ... ... || . ........|..||||. . |.
caqywpeegg..tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
.....   ..|| . |.| |....||.||.||||.... 
GtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0043336 (Phosphotyrosine protein) phosphatases II 3-142 2.4e-27 91.5 In-house 130-264 (278) alignment 
Range on Protein: 3-142
Range on HMM: 130-264/278.0
CHQYWPngPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRrsGSNRPIVVHCSDSITRS
|.||||   .  ... ..|.|..| .  . ...||. .... .|.. ||.... ..|  .| . . |.. |..  | . ..   || |..||||. . |.
caqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRT

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQ
.....   ..||.. |.| ||...||.||.|||| .....
GtfialyllleqlekeggvdleeavkelreqRpgavqtps
0051299 (Phosphotyrosine protein) phosphatases II 3-141 2.6e-27 91.5 In-house 134-272 (288) alignment 
Range on Protein: 3-141
Range on HMM: 134-272/288.0
CHQYWPNgPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDM----NSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRrsGSNRPIVVHCSDS
|.||||.  .  ... |.|.|..|..  .... ||. ....     .|.. || ... |||  .|   . . . |.. || . ..   .. |.|||||. 
caqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaG

ITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
. |......   ..|| . |.| |....||.||.|||| ... 
vgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 3-142 2.7e-27 91.3 In-house 150-286 (308) alignment 
Range on Protein: 3-142
Range on HMM: 150-286/308.0
CHQYWPNG--PTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQrrsgSNRPIVVHCSDSIT
|.||||.    .  ......|.|..| .  .....||. ......|.  || ... |||  .| . . . . |.. || . .    .. |||||||. . 
caqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvG

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQ
|.. ...   ..|| . |.| |.|..||.||.|||| ... .
RtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-141 3.7e-26 87.1 In-house 141-276 (298) alignment 
Range on Protein: 3-141
Range on HMM: 141-276/298.0
CHQYWPNGpTAAVFNYISVKLINEvQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGsNRPIVVHCSDSITRS
.|.|||.   .. .. |.|.| .. .| . .| |.. ... ..    .|.||. |.|   |  .|.... || . |  .|...| |.|..|.||. ..||
yhkywPde.gketygeitvsllsk.eefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqag.nkpvivqCsaGvgRs

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
  ... .  .|..| ||  |.||.||.||..||| . ..
GtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
0040439 (Phosphotyrosine protein) phosphatases II 3-141 1.3e-25 85.9 In-house 96-232 (249) alignment 
Range on Protein: 3-141
Range on HMM: 96-232/249.0
CHQYWPNgPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSITRS
|.||||.  .  ... ..|.|... . ......||. ....  |   || ..| |.|  .| . . ... |.. .| . ... ... |..||||. . |.
caqywpl.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
.....   ..|| . |.| ||...||.||.||||.....
GtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp
0042113 (Phosphotyrosine protein) phosphatases II 3-142 1.4e-25 85.6 In-house 94-230 (245) alignment 
Range on Protein: 3-142
Range on HMM: 94-230/245.0
CHQYWPNgPTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRsGSNRPIVVHCSDSITRS
|.||||.  .  ... ..|.|..| .  .....||. .... ...  .|.... ..|  .| . . ... |.. .| . ... .|| |..||||. . |.
caqywpl.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQ
.....   ..||.. |.| .|...|| ||.|||| .....
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtps
DSPc_SM00195 3-140 3.4e-25 84.2 In-house 111-247 (263) alignment 
Range on Protein: 3-140
Range on HMM: 111-247/263.0
CHQYWPNG-PTAAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSgsNRPIVVHCSDSITR
|..|||.   .  .|..|||||... ... .||.||. ..  .     .| |.| .||   |   . . . .|.  |.  ...|  . |||||||. . |
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgR

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPS
........ .... . |.  |.|.||| ||.|||| . .
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
PTPc_SM00194 3-140 3.4e-25 84.2 In-house 111-247 (263) alignment 
Range on Protein: 3-140
Range on HMM: 111-247/263.0
CHQYWPNG-PTAAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSgsNRPIVVHCSDSITR
|..|||.   .  .|..|||||... ... .||.||. ..  .     .| |.| .||   |   . . . .|.  |.  ...|  . |||||||. . |
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgR

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPS
........ .... . |.  |.|.||| ||.|||| . .
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
subfamily_PTPRD_pd Subfamily PTPRD 3-136 1.5e-23 78.3 In-house 133-262 (564) alignment 
Range on Protein: 3-136
Range on HMM: 133-262/564.0
CHQYWPNGpTAAVFNYISVKLINEVQESgSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQrRsGSNRPIVVHCSDSITRS
||.|||.  . . .... |.| .|.. .  .. ||| .|. .|    .| | . |.|   |.  .  .. ||   |.. . .   . |||||||  . |.
chkYWPek.gtetygeltVtleeeeela.dyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRT

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
 ...| .  .|..| |.  |..|.||.|| ||. 
GtfividamlerikeektvDiyqyvkalrkqRna
Y_phosphatase Protein-tyrosine phosphatase 3-141 1.9e-23 78.5 Pfam-A 84-223 (235) alignment 
Range on Protein: 3-141
Range on HMM: 84-223/235.0
CHQYWP-NGPTAAVFNYISVKLI-NEVQESGSIIRRTFGIKDMNSG-YCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQrrSGSNRPIVVHCSDSI
|.|||| .  .   .. |.|.|  .| ... ... |.. .|. ..     .| ||..|||   |  .... . ||   |  ..  . .. |.|||||. .
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGv

TRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
 |......   ..||.. |.  |..||||.|| |||| . | 
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 3-141 1.9e-23 78.5 In-house 84-223 (235) alignment 
Range on Protein: 3-141
Range on HMM: 84-223/235.0
CHQYWP-NGPTAAVFNYISVKLI-NEVQESGSIIRRTFGIKDMNSG-YCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQrrSGSNRPIVVHCSDSI
|.|||| .  .   .. |.|.|  .| ... ... |.. .|. ..     .| ||..|||   |  .... . ||   |  ..  . .. |.|||||. .
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGv

TRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQ
 |......   ..||.. |.  |..||||.|| |||| . | 
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
0045098 (Phosphotyrosine protein) phosphatases II 3-141 4.8e-22 74.1 In-house 106-258 (278) alignment 
Range on Protein: 3-141
Range on HMM: 106-258/278.0
CHQYWPNgPTAAVFNYISVKLINEVQEsGSIIRRTFGIKDM----NSGYCSTVVQLQLTNWLPDGQCANY--STIGDLYALVTDNQR-----------RS
|.||||.     ... ..|.|..| .  . .. ||. . .     ..... .| .|....|   |   .   . . .|.  . . ..             
caqywpe.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

GSNRPIVVHCSDSITRSAMYCVTHNAIEQAklEQGSDLFQIVKTLRMQRPG-GIPSQ
.|. |..||||  . |...... .  .|.   |.| ||...||.||.||||  ....
dsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl
0037934 (Phosphotyrosine protein) phosphatases II 3-141 7.2e-22 73.6 In-house 90-228 (243) alignment 
Range on Protein: 3-141
Range on HMM: 90-228/243.0
CHQYWPnGPTaaVFNYISVKLINEVQESGsIIRRTFGIKDMN-SGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRR------SGSNRPIVVHC
|.|||| |..  ... ..|.|..| . .. .. ||. ..  . .... .|.... ..|   |   . . . |.   |.. ...        |..|..|||
caqywp.gev..tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SDSITRSAMYCVTHNAIEQAkleqGSDLFQIVKTLRMQRPG-GIPSQ
|  . |......    ...     | ||...||.||.|||| .....
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 3-138 1.1e-21 71.9 In-house 127-276 (301) alignment 
Range on Protein: 3-138
Range on HMM: 127-276/301.0
CHQYWPNGPT-AAVFNYISVKLINEVQESGSI----------------IRRTFGIKDMNsgYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRS
|.|||||. .    |  ..|.|.||      .                | |.| .|  .     .|.|||.|.|  ||   .. |.      |   |.. 
ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki

GSnRPIVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
|   |.||||||.. || .||    ..||.| |   |.||..|..| ..|| .
gg.gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaV
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3-135 1.2e-21 72.1 In-house 131-260 (318) alignment 
Range on Protein: 3-135
Range on HMM: 131-260/318.0
CHQYWPNGpTAAVFNYISVKLINEVQESGSIIrRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGsNRPIVVHCSDSITRS
.|.|||.   .  .. . |.| .||. |  .. |.| ..  ..    .| | . |.|   |  .. ... ||   |.  |..|| ..|||||||  . | 
vhryWPsk.gsrsygklvvelkeevelsdyvl.refkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpivvhCsaGvGrt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
 ....    .|..| |.  |.||.||.|| ||.
GvfiavdillerikaealvDvfqtvkqlreqrn
subfamily_PTPN3_pd Subfamily PTPN3 3-138 7.1e-19 62.8 In-house 126-258 (280) alignment 
Range on Protein: 3-138
Range on HMM: 126-258/280.0
CHQYWPNGPTAAVFNYISVKLINEvQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVtdNQRRSGSNRPIVVHCSDSITRS
||||||.      .  .|||. .| .|. |.. | . .|| ..    ...||| ..|   |   . . . ..   |  .. |||...|.|||||  | |.
ChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv..rklrsgkeePvvvhCsaGigrt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
 .. .   |.     ..     .||.|.| ||   .
Gvlilletalalieaaepvypldivrtmrdqramlv
subfamily_PTPRB_pd Subfamily PTPRB 3-135 2.5e-18 61.2 In-house 136-265 (293) alignment 
Range on Protein: 3-135
Range on HMM: 136-265/293.0
CHQYWPNGPTAAVFNYISVKLINEVQESGsIIRRTFGIKDmnSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSITRS
|..|||.  .. ..  |.|.|..| . .   . |.. |.   .  . .| |.. | |   |   . .|. |.   | ...... |.||||||||  . |.
CeeYWPadeepvlyGdikvtlvaeeeled.wvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
  .   .. ... . |.  |.| ||  ||..| 
GtfialdrllqaieeedyvdifgivaelReeRn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-135 2.8e-17 57.8 In-house 133-264 (297) alignment 
Range on Protein: 3-135
Range on HMM: 133-264/297.0
CHQYWPNGPTAAvFNYISVKLINeVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWlPDGQCANYSTIGDLYALVTDNQR-RSGSNR-PIVVHCSDSIT
| .||..  ... | ..||.|   |.|    |.|.. ..  ..     | | | ..| || .  .  ..  |  |... .   |. .  |..|||.  . 
caryWsdkgvtt.fGdvsvvlls.vsereGfikrelevtkgkakarrvvkqyqfveW.PdkaverkdsassllklisevrkdfsqnaegPllvhclaGvG

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
| ....   . . .|| |.  |.|..|| || .||
rtgvlltidsvvaeakrekevdifglvkklrqerp
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-135 2.8e-17 57.0 In-house 128-256 (515) alignment 
Range on Protein: 3-135
Range on HMM: 128-256/515.0
CHQYWPNGPTAAV-FNYISVKLINEVQESGSIIRRTFGIKDMNsgyCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRsgSNRPIVVHCSDSITR
| .|||. |. .| | .|.|.|.     .| |.|.   .|. .   . || | ..|.|   |   . |..  |   |  .. .   . |...|||  . |
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgq..ythpliihcsaGvGr

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
  ...  .. . .||  .  |.|..|. .| .||
tGvvisidsvvahakttrmvdvfnfvtnirqkrp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-139 3.2e-17 57.6 In-house 132-272 (325) alignment 
Range on Protein: 3-139
Range on HMM: 132-272/325.0
CHQYWPNG-PTAAVFNYISVKLINeVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQ---RR-SGSNRPIVVHCSD
| .|||.    .  |  . |||.  ..|    . | . .|... |   .| |.||  |   |.    .|.  .  ||   .   .  . .  ||.||||.
cavywpkemgksktfGglevklrt.ieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

SITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIP
 . |. ..   . |...   |   |.|. || || .||  . 
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmve
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-136 7.8e-17 56.2 In-house 132-260 (288) alignment 
Range on Protein: 3-136
Range on HMM: 132-260/288.0
CHQYWPNGPTAAVFNYISVKLInEVQESGSIIRRTFGIKdmNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSgsNRPIVVHCSDSITRS
|..|||.. .   .  . |.|. |..| .... |.. ..   ..   .. |.| . |  .|  ..   . .|   |  ..       ||.||||. . |.
CeeYWPdadkpknyGsvtvtlv.eskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
  . . ...|.. . |.  |.. .|. ||.||. 
gtFialdalidaveeedyiDvagtvaklRkqRal
subfamily_PTPN13_pd Subfamily PTPN13 3-138 1.9e-16 55.2 In-house 119-252 (273) alignment 
Range on Protein: 3-138
Range on HMM: 119-252/273.0
CHQYWPNGP--TAAVFNYISVKLINEVQESGSIIrRTFGIKDMNSGYCSTVVQLQLTNWlPDGQCAnySTIGDLYALVTDNQRRSGSNRPIVVHCSDSIT
||.|||.    .  | | . |.|.. .. .|  . |.. .||..||    |..|....| || .    |.  .|  .|.  .|   .. |||||||  | 
chrywPesknkklkvsnrlevellkvqkldgfvv.ralavkdsesgesrevahlnfvkw.PdhgvP..ssaaellqfvaevrrlqtdagPivvhcsaGiG

RSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
|| .. . . ...  . ..  |. .||..|| || | .
rsGtlitidvvlglierdkefdvkeivrklreqrqgvv
subfamily_PTPN6_pd Subfamily PTPN6 3-142 3.5e-16 54.1 In-house 140-284 (306) alignment 
Range on Protein: 3-142
Range on HMM: 140-284/306.0
CHQYWPNGPTAAVFNYISVKLINEvQESGSIIRRTFGIK-DMNSGYCSTVVQLQLTNWlPDGQC-ANYSTIGDLYALVTDNQRRSG--SNRPIVVHCSDS
| .|||.  .   .  |||. ..| ..  . | |.. ..   ... . .|.|.. ..| ||  . .. ... |.   |. .|...   ...|||||||. 
CarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksW.PdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

ITRSAMYCVTH---NAIEQAKLEQGSDLFQIVKTLRMQRPGGIPSQQ
| |   . |.    . ||. .|.   |. ..||..| || | .  .|
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteq
subfamily_PTPRA_pd Subfamily PTPRA 3-136 4.2e-16 53.7 In-house 143-276 (330) alignment 
Range on Protein: 3-136
Range on HMM: 143-276/330.0
CHQYWPNGPTaAVFNYISVKLINeVQESGSIIRRTFGIKDMNS----GYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSnrPIVVHCSDS
|.||||.  .   .  | |.. . .... ..  | | .....          | |. .| |   |  ..   . .| . |   ...|..  |||||||  
caqywPdeGl.vtyGnirveved.etvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaG

ITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
. |.  ..|  . .|. | |.  |.|..|| ||.||| 
vGrtGtfivldavlervkaerkvdvfefvkrlrlqrpq
subfamily_PTPN23_pd Subfamily PTPN23 3-135 6.7e-16 52.9 In-house 125-260 (288) alignment 
Range on Protein: 3-135
Range on HMM: 125-260/288.0
CHQYWPNGP-TAAVFNYISVKLiNEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTD--NQRRSGSNRPIVVHCSDSI
...|||.    . .|. .|| | ..|.|..  ..|.. ..  ..    .|. ||||.|   |  |  .|. ..   | .  ....  |. |.|||||  .
vdrYwPedkgetvkfgdlsvtl.ksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGv

TRSAMYCVTHNAIEQAKLEQG-SDLFQIVKTLRMQRP
 |. ....   |... . ..|  |. |.|..|| || 
gRtgvfalvyaavrelekgnglldiiqvvsrlreqRr
subfamily_Ptp69D_pd Subfamily Ptp69D 3-136 8.3e-16 53.0 In-house 133-267 (307) alignment 
Range on Protein: 3-136
Range on HMM: 133-267/307.0
CHQYWPNGpTAAVFNYISVKLINEVQeSGSIIRRTFGIKDMN--S---GYCSTVVQLQLTNWLpDGQCANYST-IGDLYALVTDNQRRSgsNRPIVVHCS
|..|||.  .   .. | |||..| .  .  |.|.. .  ..  |        ||| . |.|  | .  . .. . .|   | . .. .  . |||||||
cakYWpie.devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykln..rsPivvhCs

DSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
    ||...      ..| |.|.  |.|..|| || ||. 
aGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnl
subfamily_PTPRG_pd Subfamily PTPRG 3-136 3.3e-15 50.3 In-house 133-268 (563) alignment 
Range on Protein: 3-136
Range on HMM: 133-268/563.0
CHQYWPNgPTAAVFNYISVKLINEVQESgSIIRRTFGIKDMN-----S-GYCSTVVQLQLTNWlPDGQCANYStIGDLYALVTDNQRRSGSNRPIVVHCS
|..|||.  ..  .. ..|.||.| . . .   ||. ||...     .  .  .| | . |.| || .  ..| . .|   . ... .     |||||||
cdvYWPk.desetygalqvtlieeevla.lytvrtlviknlklkkkkqcdteklvrqyhytkW.PdhgvPehs.lpvLifvkkssaankaeaGPivvHcs

DSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
  ..|. .|.|    ..| . |.  ..|...|..|.||. 
aGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnf
subfamily_PTPN12_pd Subfamily PTPN12 3-136 5e-15 50.1 In-house 125-258 (290) alignment 
Range on Protein: 3-136
Range on HMM: 125-258/290.0
CHQYWPNGPTAAV-FNYISVKLINEVQESGSIIRRTFGIKDMnsGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRrsGSNRPIVVHCSDSITR
|..|||.    .. |. ..|.|..| . .  .. ||. ..    . . .| |.. |.|   |  .. ... .| .|| . |.   .. |.|||||  . |
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGr

SAMYCV---THNAIEQAKLEQGSDLFQIVKTLRMQRPG
    ..   ....... |...  |.|..| .|| ||. 
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraa
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-138 2.9e-14 47.8 In-house 115-251 (274) alignment 
Range on Protein: 3-138
Range on HMM: 115-251/274.0
CHQYWPNGPTA---AVFNYISVKLINEVQESGSIIRrTFGIKDMNSgyCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSN-RPIVVHCSDS
|..|.|.   .     .. ...|  . |.. .  .| .. .| ...  . .|.    |.|    .  . .|. || . | ......  .  |.|||||  
CavyfPdaedyeiserygdveikvekiverndysvr.klvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

ITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
| |  ..  ...|. | . |.  |...||  ||..| | .
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv
subfamily_CG7180_pd Subfamily CG7180 3-138 3.9e-14 47.0 In-house 126-273 (296) alignment 
Range on Protein: 3-138
Range on HMM: 126-273/296.0
CHQYWPNGPtAAVFNYISVKLINEVQESgSIIRRTFGIKDM----------NSGYCSTVVQLQLTNWLPDGQCANY-STIGDLYALVTDNQRRS---GSN
...||||    . .  | |....| | .  .  ||| .. .           .    .| ..||| |  . ..    ... .|   |   ...      .
ypsywpnks.keqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

RPIVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
 |.||..||  .|| .|.    ..|... |.  |.|. ||||| .||. .
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLv
0051429 (Phosphotyrosine protein) phosphatases II 3-142 2.1e-13 46.0 In-house 63-212 (272) alignment 
Range on Protein: 3-142
Range on HMM: 63-212/272.0
CHQYWP-----------NGPTAAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYstIGDLYALVTDnqrrsgsNRPI
|..|||           ....   .....|.|. |.. .  |.|.   .. .. |   .| .|. |.|. .| . ..  . .| .|. |       ..|.
cdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpv

VVHCSDSITRSAMYCVTHNAIEQAKLEQGSD--------LFQIVKTLRMQRPGGIPSQQ
.||||  . |......    ...  ||.  |        |...|. || |||| .....
lvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqtee
0036282 (Phosphotyrosine protein) phosphatases II 3-142 5.3e-13 44.5 In-house 54-157 (174) alignment 
Range on Protein: 3-142
Range on HMM: 54-157/174.0
CHQYWPNgptaavfnyisvklinevqesgsiirrtfgikdMNSGYCSTVVQLQLTNWlPDGQCANYSTIGDLYALVTDNQRRsGSNRPIVVHCSDSITRS
|..|||                                  . . .  ...|.. ..| ||... . |.. ... .| . . . ....|..||||  . |.
cinywpe.................................lredlerlgiqylylpw.pDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRt

AMYCVTHNAIEQAKlEQGSDLFQIVKTLRMQRPGGIPSQQ
.. ..    . . . |   | ...|..||.||||......
Gtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-136 5.4e-13 43.6 In-house 94-222 (239) alignment 
Range on Protein: 3-136
Range on HMM: 94-222/239.0
CHQYWPNGpTAAvFNYISVKLINEvQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWlPDGQCANYST-IGDLYALVTDNQRrsGSNRPIVVHCSDSITR
||||||.  |.  .  . | | .  .     | ||| . ..       | | ..| | ||    .|.| .  |   .| .       || |.|||  . |
chqywpds.tsk.ycnlrvtlrkt.evfadyiirtfvmsqvgqteeryvyqyhftvw.pdkgvpqyatavlglrrkitkdsl..pgarpwvihcsagvgr

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
.  . |    . ||| ..  |.|. ||..| .|| 
tgaflvidamlrqakkqktvdifnyvkairedrph
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-136 5.4e-13 43.6 In-house 93-221 (239) alignment 
Range on Protein: 3-136
Range on HMM: 93-221/239.0
CHQYWPNGpTAAvFNYISVKLINEvQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWlPDGQCANYST-IGDLYALVTDNQRrsGSNRPIVVHCSDSITR
||||||.  |.  .  . | | .  .     | ||| . ..       | | ..| | ||    .|.| .  |   .| .       || |.|||  . |
chqywpds.tsk.ycnlrvtlrkt.evfadyiirtfvmsqvgqteeryvyqyhftvw.pdkgvpqyatavlglrrkitkdsl..pgarpwvihcsagvgr

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
.  . |    . ||| ..  |.|. ||..| .|| 
tgaflvidamlrqakkqktvdifnyvkairedrph
subfamily_PTPN9_pd Subfamily PTPN9 3-135 1.7e-12 42.0 In-house 127-270 (297) alignment 
Range on Protein: 3-135
Range on HMM: 127-270/297.0
CHQYWP-NGPTAAVFNYISVKLINeVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALV-----------TDNQRRSGSNRP
| |||| .  ..| |  .||. .. |.|.     |.. ||... .   .|.  |.. |   |   . ... |.   |           .|...   |. |
cgqyWpleeessaefgdlsvsnve.veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

IVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
||||||  | |.  ..    .... . ..  |... ||.|| || 
ivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqra
subfamily_PTPRN_pd Subfamily PTPRN 3-141 4e-12 40.5 In-house 142-278 (297) alignment 
Range on Protein: 3-141
Range on HMM: 142-278/297.0
CHQYWPNGpTAAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRrsGSNRPIVVHCSDSITRS
|..|||.   ..|..   |.|. |   .   . |.| .|....    || |.    |   |  |.  .. ..   |    |  |   ||||||||   |.
ckrywpde.GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..GrscpivvhcsdGaGrt

AMYCVTHNAIEqaKLEQGS---DLFQIVKTLRMQRPGGIPSQ
 .|..    ..  .| .|    |.   .. || |||| . ..
Gvyilidlvln..rllkGvkeidiaatlehlrdqrpglvktk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 3-138 1.8e-11 38.7 In-house 87-222 (237) alignment 
Range on Protein: 3-138
Range on HMM: 87-222/237.0
CHQYWPNGPTAAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSITRS
||.|||.    | .  ..| |  . . |   .|     | ..      . | |.| |   |   . ...  .   . .. .      | ..|||  . |.
chkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrt

AMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
... |    . ||| ..  |... |...  .||  |
giflvidamlrqakekkvvdiynyvysieedrpyii
0041856 (Phosphotyrosine protein) phosphatases II 3-140 2e-11 39.3 In-house 67-156 (182) alignment 
Range on Protein: 3-140
Range on HMM: 67-156/182.0
CHQYWPngptaavfnyisvklinevqesgsiirrtfgikdmnSGYCSTVVQLQLTNWLPDGQCAnYSTIGDLYALVTDnqrrsgSNRPIVVHCSDSITRS
...|||                                    . .  ...|.. ..|  .| .   ... |.   | .      ...|..||||  . |.
eelywp....................................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRt

AMYCVTHNAIEQakleqGSDLFQIVKTLRMQRPGGIPS
.....    ...     | .|...||..|..|||.. .
gtlvaaylmkkl.....gvsleeavklvrsrRpgmvit
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-138 1.4e-10 35.6 In-house 106-247 (270) alignment 
Range on Protein: 3-138
Range on HMM: 106-247/270.0
CHQYWPNGPTA---AVFNYISVKLINEVQESGSIIRRtFGIKdmNSGYCSTVVQLQLTNWLPDGQCANYS---TIGDLYALVTDNQR-RSGS--NRPIVV
| .|||. |       .  |.|  ..|..|.|.|..|   ..  ..|    .|  . ..|  .|   .     .  .| ... . .| ..    . |..|
CerYWpaepkekvkledgkikvlalseekeegyiltr.lrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
|||. . |. .  ..  |..  . ..  |. .|.. || .|.  .
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-134 1.4e-09 32.0 In-house 128-258 (439) alignment 
Range on Protein: 3-134
Range on HMM: 128-258/439.0
CHQYWPNGpTAAVFNYISVKLINEVQESGSIIRR--TFGIKDMNsGYCSTVVQLQLTNWLPDGQCANYSTIGDL-YALVTDNQRRsgSNRPIVVHCSDSI
 ..|||   . ...  |.|.   ...    .||    |  .| .     ||.|.. . |      |. | . |.  |. . |...     |.|||||  .
sykywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdtt.ekertvlqfhyiawpdknvpaqashvldflrainsandke..eygpvvvhcsagv

TRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQR
 |.        |.|| |||.  |.  ||| || ||
GrtGtiialdialeqlklenkvdikgivkvlrkqr
subfamily_PTPN14_pd Subfamily PTPN14 3-134 3.1e-09 31.2 In-house 135-275 (300) alignment 
Range on Protein: 3-134
Range on HMM: 135-275/300.0
CHQYWPNG-PTAAVFNYISVKLINEV-QESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWlPDGQCAN-----YSTIGDLYALVTDNQRR---SGSNRPIV
...|.|.    .   ..   |....  ..|.|.| ... .| . |.   ||. || |.| || .. .      | . .. ..    ..      |. |..
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDW.pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQR
||||. . |. .  ..   |.  . ..  |. .....|| ||
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-136 4.5e-09 30.5 In-house 122-258 (287) alignment 
Range on Protein: 3-136
Range on HMM: 122-258/287.0
CHQYWPNGPTAAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWlPDGQCANYSTIGDLYALVT----DNQRRSGSNRPIVVHCSDS
|..|||.          || |..  . .     |.. . |...  .  | ||.| .| ||.  |  .     ..|      . .| .    |.|||..  
cykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

ITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPG
| || ..  |   ... .     |  ..|  ||..| .
iGrsGillatlvlvsrledlGrvdvaavvirlreyraa
subfamily_PTPN1_pd Subfamily PTPN1 3-138 7e-09 29.8 In-house 113-254 (290) alignment 
Range on Protein: 3-138
Range on HMM: 113-254/290.0
CHQYWPNGPT--AAVFN--YISVKLINEVQESgSIIRRTFGIKDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDS
|.||||.|    . ...   ..||||.| ..|   ..|.. ......  . ....   | |   |     ..  ..   | .    |    | |.|||  
caqywPqgeeekellledtklkvkliseerks.yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

ITRSAMYCVTHNA---IEQAKLEQGSDLFQIVKTLRMQRPGGI
| ||  .|.       ||. .  .. |. . .  || .| | |
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGli
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3-137 1.1e-08 29.1 In-house 136-265 (290) alignment 
Range on Protein: 3-137
Range on HMM: 136-265/290.0
CHQYWPNGPT-AAVFNYISVKLINEVQESGSIIRRTFGIKDMNSGYCSTVVQLQLTNWlPDgQCANYSTIGDLYALVTdNQRRSGsnrPIVVHCSDSITR
|.||.|.    .  |  |.|   .| ..   ||..|. ..|..||    .  |..  | || ..   ||.  |  | .  .. ||   |.|||||  | |
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiksw.pd.ksvalstlallrtlri.lrkasG...pvvvhcsaGiGr

SAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGG
.  .     ...     .  || ..|..||  | . 
tGtfvaievglqilldGkeldlldlvralrnsrlns
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-141 9.2e-06 20.0 In-house 113-245 (290) alignment 
Range on Protein: 3-141
Range on HMM: 113-245/290.0
CHQYWPNGPT-AAVFNYISVKLINEVQESGsIIRRTFGIKdMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTdNqrrsgSNRPIVVHCSDSITR
| .| |.       |. ..||  . ..| . ...|.  .|  . .   ||   .| .| .     .  |. .|   |  .     |. |..||| | | |
CakYvpesvgeelkfkgltvkCkskekedd.vetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a.....sktpvivHcvdGiSr

SAMYCVTHNAIEQAK-LEQGSDLFQIVKTLRMQRPGGIPSQ
||.      .      ...   | ...|.|| ||   | |.
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsa
0051082 (Phosphotyrosine protein) phosphatases II 11-140 7.9e-08 27.6 In-house 57-138 (151) alignment 
Range on Protein: 11-140
Range on HMM: 57-138/151.0
PtaavfnyisvklinevqesgsiirrtfgikdmnsgycSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDnqrrsGSNRPIVVHCSDSITRSAMYCVTHN
                                       .|.......| . |   .. .. ..  |. |      .| |..||||  . |... ..   
g.....................................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalyl

AIEQakleqgSDLFQIVKTLRMQRPGGIPS
 ...       .|..... .|..||| . .
mllg......vsleealeeyrlkrpgvvqp
0049772 (Phosphotyrosine protein) phosphatases II 28-144 6.1e-07 24.9 In-house 167-263 (314) alignment 
Range on Protein: 28-144
Range on HMM: 167-263/314.0
QesgsiirrtfGIKDMNSGYCSTVVQLQLTNWLPdGQCANYSTIGDLYALVTDNqrrsGSNRPIVVHCSDSITRSAMYCVTHNAIEQAkleqGSDLFQIV
.          .. . .. .  .....  ...   |..   . . ...... ..      ..|..|||.. . |.. ..|.   . .     | .| ...
k..........eelydpelferlgikylripvpD.gsaplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleeal

KTLRMQRPgGIPSQQCM
. .|..||   |.. ..
edvrlkRp.inpnpgfi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 29-141 7.2e-09 29.8 In-house 160-267 (301) alignment 
Range on Protein: 29-141
Range on HMM: 160-267/301.0
ESGSIIRRTFGIKDMNSGYC-STVVQLQLTNWLPDGQCANYSTIGDLYALVTDnqrrsgSNRPIVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIV
 . .|..||. ..|    .   ||.  | ..|   |    .  . ||  || .      |..|||||||. | ||  .  |.    . . ..  .| . .
lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigteylareveadptielteal

KTLRMQRPGGIPSQ
| || .|  |.  .
khlrehrwngvqtn
0043147 (Phosphotyrosine protein) phosphatases II 41-142 2.6e-11 39.0 In-house 55-148 (172) alignment 
Range on Protein: 41-142
Range on HMM: 55-148/172.0
KDMNSGYCSTVVQLQLTNWLPDGQCaNYSTIGDLYALVTDNQrRSGSNRPIVVHCSDSITRSAMYCVTHNAIeqakleQGSDLFQIVKTLRMQRPGGIPS
    .... ...|.. ..|   | . . . . ... .. . .    .. |..||||  . |... .. .  .      .| .|...|...|..|||....
lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

QQ
..
ps
0048076 (Phosphotyrosine protein) phosphatases II 41-141 1.1e-10 36.8 In-house 37-129 (145) alignment 
Range on Protein: 41-141
Range on HMM: 37-129/145.0
KDMNSGYCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRsgsNRPIVVHCSDSITRSAMYCVTHNAIEqakleQGSDLFQIVKTLRMQRPGGIPS
 .. ...  ...|.. ..|   |    .... ...... . ...   ..|..||||  . |...... .  ..     .| .|..... .|.||||..|.
tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn

Q
.
p
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 46-135 4.1e-06 20.4 In-house 129-216 (392) alignment 
Range on Protein: 46-135
Range on HMM: 129-216/392.0
GYCSTVVQLQLTNWlPDGQCANYSTigDLYALVTDNQRRSGSNR-PIVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRP
  . || | ..|.| || .  ....   |  .. . .   |.   |...|||  . |...     . . .||  .  |.|..|  .| .||
ddartvaqfhftew.Pdkdvpkhts..sllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp
0048179 (Phosphotyrosine protein) phosphatases II 47-142 4.3e-10 35.0 In-house 45-132 (144) alignment 
Range on Protein: 47-142
Range on HMM: 45-132/144.0
YCSTVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRrsgSNRPIVVHCSDSITRSAMYCVTHNAIeqaklEQGSDLFQIVKTLRMQRPGGIPSQQ
.  ...|.. ..|   |    .. . ...... . ..   ...|..||||  . |...... .  .     ..| .|..... .|..|||..|...
leregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg
PTPc_DSPc_SM00012 50-141 1.6e-13 46.1 In-house 1-93 (105) alignment 
Range on Protein: 50-141
Range on HMM: 1-93/105.0
TVVQLQLTNWLPDGQCANYSTIGDLYALVTDNQRRSGSNRPIVVHCSDSITRSAMYCVTHNAIEQAKLE-QGSDLFQIVKTLRMQRPGGIPSQ
|| ... |.|   |   . . | .| . | .|.. |.|. |.|||||. . |......   ...| . | .  |.||||| ||.|||| . ..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
0049260 (Phosphotyrosine protein) phosphatases II 57-142 9.8e-11 37.1 In-house 59-137 (152) alignment 
Range on Protein: 57-142
Range on HMM: 59-137/152.0
TNWLPDGQCANYSTIGDLYALVTDNQrRSGSNRPIVVHCSDSITRSAMYCVTHNAIeqakleQGSDLFQIVKTLRMQRPGGIPSQQ
  . ||. . . | . .   |. .   .  .. |..||||  . |......    .      .| .|...|. .|..|||..|...
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpg
0046846 (Phosphotyrosine protein) phosphatases II 60-141 2.5e-09 32.7 In-house 84-159 (176) alignment 
Range on Protein: 60-141
Range on HMM: 84-159/176.0
LPDGQCANYSTIGDLYALVTDNQRRSgsnRPIVVHCSDSITRSAMYCVTHnaieQAKLEQGSDLFQIVKTLRMQRP-GGIPSQ
 ||... ... . .|.... . ...    .|..||||  | |......        .||.| .........|.||| | ....
wpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp
0044763 (Phosphotyrosine protein) phosphatases II 60-141 7e-08 27.8 In-house 83-157 (178) alignment 
Range on Protein: 60-141
Range on HMM: 83-157/178.0
LPDGQCAN-YSTIGDLYALVTDNQRrsGSNRPIVVHCSDSITRSAMYCVTHNAIEQakleqGSDLFQIVKTLRMQRPgGIPSQ
.||. . . .. . ...... . .    ...|..||||  . ||.. ..    ...     | .|..... .|..|| ..|..
ipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 66-138 1.4e-12 42.2 In-house 171-242 (267) alignment 
Range on Protein: 66-138
Range on HMM: 171-242/267.0
ANYSTIGDLYALVTDNQRRSGsNRPIVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGI
 |   .  |..... ||   | |||.||.||| . ||  . | .  .|.|| |. ||.|. .. .| ||.| .
nnkpylkplfgilaknqleng.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-140 4.8e-09 30.0 In-house 364-423 (440) alignment 
Range on Protein: 81-140
Range on HMM: 364-423/440.0
NQRRSGSNRPIVVHCSDSITRSAMYCVTHNAIEQAKLEQGSDLFQIVKTLRMQRPGGIPS
.| | |   ||.|||   |  | ..|   | .|| . .   |.|| .. ||. ||  .|.
eqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvpt
uDENN uDENN domain 143-179 2e-08 23.6 Pfam-A 27-63 (65) alignment 
Range on Protein: 143-179
Range on HMM: 27-63/65.0
CMPEGVQLSKEPSHHFSFHSLLITRENGSRQYGSVLT
|.|||... .. ..  .|.|  .|.|.||| ||. |.
CfPeglnfvtsreqkpeffsfvLTdedgsriyGfClr
DENN DENN (AEX-3) domain 225-411 5.1e-46 146.2 Pfam-A 2-184 (185) alignment 
Range on Protein: 225-411
Range on HMM: 2-184/185.0
ATKSLCFITSLPIFQPTRSYLEQLYAISVGNDRgsLPIESYLYNLLYETSLPGPGVTLKL--HGPLDLITWRLPGNEELPLCDYSFRAFFESISLKNVLQ
. |.||... ||.|.  ...|..|.  .  ..   ||.||.. |||.|  || || ||||  ..  . |.   | ..|||| |......|. .|..||||
ipkalcilsrlpffelfkkiLkalekrlksssk..lplesfianlllevplPapgktlklkslsvkekillqrpssselPledvdleelfrcLsienvlq

LLTCVLLEQQILLKANDFHQLMMCAECITALLFPYVWPHVFVPILPSSQHGFLDAPVPFLMGLRMNTDSstseLDILNKASLSSFDLDH
|...||||..|.| ..... |. .||...|||.|..| |...|.||.|   .|.||.||..|.  .  .    |.  ... .  .|||.
lfeavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslle....leekpledvvlvDldt
dDENN dDENN domain 544-619 1.2e-14 43.3 Pfam-A 2-68 (68) alignment 
Range on Protein: 544-619
Range on HMM: 2-68/68.0
SDSVRNIFCNYFVEHFMNYEQFIIMPDQSYQqwlrnreqfENFDKTAFLSDQPQFSRTFYSAFLETAMFTLFIDQK
.. || .| ..|.. . .|..|.. . .| .          .|.| |||..... .| |.|.|||| ||. ||...
dqqvreaFlrffasllggYrnflrkerkspe.........vsFqkeaFlksrskshrsFlsqfletqmFaeFieer
RUN RUN domain 762-967 6.5e-22 64.2 Pfam-A 1-128 (133) alignment 
Range on Protein: 762-967
Range on HMM: 1-128/133.0
NLCDLLERIWGHGLKKRESksslwahlrafgetlcheeepklspprsalsrsvtpdsslplslnrhqhydeshysprmfnqmsldesfspspssrrpstp
.||. ||... |||.. ..                                                                                 
sLckaleallshGLrrsse.................................................................................

sLFRRRFQSSELKSLVGAILQPPPSTFLDdLKIINNMREIKTD-----VGRARAWVRLCLEKKTLSRHLSHLLSNTNLTRQRYRSYAFLLTDDEKEQFLL
   .  ...|.  .|. .. .. |..    |. .... .....     ....|||.|| |..| |...|..|.||..|... | . |..  ... ...| 
.ralglkkessfwallekvakvlpeaesl.lskvqelealhsskkrsldskfrawirlaLnekvLtkwlellvsnaellssyYerealvadsefgsills

HLLSLSAGDFN
.|  ||| ||.
lLvglsaldft
PLAT PLAT/LH2 domain 980-1075 6.1e-09 23.7 Pfam-A 1-104 (113) alignment 
Range on Protein: 980-1075
Range on HMM: 1-104/113.0
YRVLVVSEGKYLGLSSACLYVKVGGEGGDSDTVAIP-------RGNYQVEFSC-RNLGPLTCVRLSHDNSGLVRSLFVEMVLVHCITTGQTYRFNCGRYF
|.| .|.  .    ..|  |... |. |.|   ..           ....|..  .||.|. ..| ...||  ...|.. .||  . ||.|. | | . .
yqvkivtgdetgagtdanvyislygskgksgeipllepelkndgstdeftfdtdedlGdlgaiklkneisghsdewflkrilVkdgetggtvtFpcnswv

ARAE
 ..|
dnde
RUN RUN domain 1168-1294 8e-11 28.3 Pfam-A 2-120 (133) alignment 
Range on Protein: 1168-1294
Range on HMM: 2-120/133.0
FVKAIENAFQLGYK----CTRKFHKPLYIWDHIERVsmteaaarqeetdggeegpKSPLPSYLSIVSKINGLASIGKE------EKAMLFFLIGLRDHVL
..||.|. .. | .      ... |   .|. .|.|                   . .||.  |..||.. |  . ..       |. ..  ..| ..||
LckaleallshGLrrsseralglkkessfwallekv...................akvlpeaesllskvqelealhsskkrsldskfrawirlaLnekvL

SDWIQIITSSS-STELMYDPVSFLRDPELISFLLDTIN
..|.. . |.. ... .|.. ....|.|  | || .. 
tkwlellvsnaellssyYerealvadsefgsillslLv