Gene PTPRD-22 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP076_AA protein Get Run
AqueP076_AA_16-157 phosphatase_domain Get Run
AqueP076_AA_945-1303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 6-147 1.6e-10 35.3 In-house 131-270 (301) alignment 
Range on Protein: 6-147
Range on HMM: 131-270/301.0
KFAISIGLSTPSGMILGEYNIILLNEETF--NGYIERKFEVKNNN-TGATQSVTQYQITNWDSTGkltNPQTILLVIEEMYRTqrKRGNTSIVVHCSDTV
| .  . ..... . .| ..| . |.|.   .  ..|..||..     ||..|| || ..|   |    |..   . . |     |. .  ||||||. .
kceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGi

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVDRI
|||  | ..    .. ...  |.. . ||  | ..  .|||. ..
Grsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 15-159 7.3e-71 233.4 In-house 140-286 (290) alignment 
Range on Protein: 15-159
Range on HMM: 140-286/290.0
TPSGMiLGEYNIILLNEETFNGYIERKFEVKNNNT-GATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAAT
... . .||..| ||||||.|.|||||.||||.|. ||.||||||||||||||||.||||||||||||||.||||||||||||||||||||||.||||||
sdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaat

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVDR--IIPDYFMIYASQF
|||||||||||||||||||||||||||||||..  .| . .. | ..|
tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
0036941 (Phosphotyrosine protein) phosphatases II 17-145 5.2e-28 93.6 In-house 130-264 (297) alignment 
Range on Protein: 17-145
Range on HMM: 130-264/297.0
SGMILGEYNIILLNEET--FNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAAT
. .  |.. . ||..|.  ...|. |..||.....| .  ||....|.|.  |  ..|...|  ||.. . ...  ... ..||||. ||||..|.|| .
esltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadl

TINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVD
 ..  .   .|| .|.....|. | |.||.|||..
mlqqledklkeggvdileavkklReqRpgavqtle
0045450 (Phosphotyrosine protein) phosphatases II 17-145 1.8e-25 85.8 In-house 158-291 (307) alignment 
Range on Protein: 17-145
Range on HMM: 158-291/307.0
SGMILGEYNIILLNEETFNGYIERKFEVKNN-NTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATT
. .  |.. . ||.||. .||. |..||...  || .  ||... |.|  .|  ......|  |||. . ...  ... ..||||. |||...|.|| . 
eeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

INKCKTEGV---IDVFQVLKSQRIQKPGSVQTVD
.   ..||.   .|.....|  | |.||.||. .
lrqlekegtlldvdlleavkllreqRpgavqnpe
0037934 (Phosphotyrosine protein) phosphatases II 17-145 2.8e-21 71.6 In-house 96-229 (243) alignment 
Range on Protein: 17-145
Range on HMM: 96-229/243.0
SGMILGEYNIILLNEETFNGYIERKFEVKNNN-TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMF
...  |.. . ||.||....|. |.....| . .. |. |..|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||  |||....
gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

CAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVD
.|| . . ..   | .|.....|  | |.|| .||| .
iaaylmllll...g.vdleeavkllreqRpgkavqtps
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 18-148 6.8e-70 230.3 In-house 137-270 (287) alignment 
Range on Protein: 18-148
Range on HMM: 137-270/287.0
GMILGEYNIILLNEETFNGYIERKFEVKNNN-TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
 ..|||||| |||||. .||||||.||||.| .|..|.|.||||||||||||.|.||||||||||||.||||||||||||||||||||||||||||||||
svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin

KCKTEGVIDVFQVLKSQRIQKPGSVQTVDR--II
||||||||||||||||||||||||||||..   |
kckteGviDvfqvlksqriqkpgsvqtveqykfi
0039614 (Phosphotyrosine protein) phosphatases II 18-145 4.1e-25 84.3 In-house 151-276 (297) alignment 
Range on Protein: 18-145
Range on HMM: 151-276/297.0
GmILGEYNIILLNEETFNGYIERKFEVKNnnTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTIN
|   |.. . ||..|. .||. |..||.|  .| .  ||..| |.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . ..
g.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmle

KCKTEGVIDVFQVLKSQRIQKPGSVQTVD
 ...|| .||....|  | |.||.||| .
qlekeggvdvleavkelreqRpgavqtps
0051429 (Phosphotyrosine protein) phosphatases II 18-152 7.7e-14 47.5 In-house 84-225 (272) alignment 
Range on Protein: 18-152
Range on HMM: 84-225/272.0
GMILGEYNIILLNEETFNGYIERKFEVKNN-NTGATQSVTQYQITNWDSTGKLTNPqtILLVIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTIN
 . .| . ..|| ||... || |......  ..|..  |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   . 
tilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllll

KCKTEGVID--------VFQVLKSQRIQKPGSVQTVD------RIIPDYF
    | ..|        ......  | | ||.||| .      ... ...
gvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 18-145 5.8e-10 33.4 In-house 132-264 (287) alignment 
Range on Protein: 18-145
Range on HMM: 132-264/287.0
GMILGEYNIILLNEETFN-GYIERKFEVKNNNTGATQSVTQYQITNWdsTGKLTNPQ---TILLVIE--EMYRTQRK-RGNTSIVVHCSDTVGRSAMFCA
 | .| | ..||. .  .  |  | . . . .|  .. | |... .|    |   |     | .|..  .    .|.  .   .|||..  .||| .. |
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVD
  . ... .  | .|| .|.   | .. . ||.| 
tlvlvsrledlGrvdvaavvirlreyraalvqavv
0050432 (Phosphotyrosine protein) phosphatases II 19-147 4.1e-29 97.3 In-house 163-288 (308) alignment 
Range on Protein: 19-147
Range on HMM: 163-288/308.0
MILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKC
.. | . . ||.||....|. |..|..|...| .  ||... |||   |  ..|. .|  .|.. ...   ..  ||||||. |||.. |.|. . ..  
leygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleql

KTEGVIDVFQVLKSQRIQKPGSVQTVDRI
..|| .|||...|  | |.||.|||..  
ekeggvdvfeavkklReqRpgmvqtpeqy
0046845 (Phosphotyrosine protein) phosphatases II 19-148 4.5e-28 93.9 In-house 130-264 (284) alignment 
Range on Protein: 19-148
Range on HMM: 130-264/284.0
MILGEYNIILLNEETFNGYIERKFEVKNNN-TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTIN
...|.. . ||.||....|. |..|..|.. || .  ||....|.|   |  ..|. .|  .... . ...  |.  ||||||. |||...|.|. . ..
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllle

KCKTEG---VIDVFQVLKSQRIQKPGSVQTVDRII
  ..||   ..||....|  | |.||.|||.. ..
qlekeglllgvdvleavkrlreqRpgmvqtleqyr
0047943 (Phosphotyrosine protein) phosphatases II 19-147 6.8e-28 93.3 In-house 132-261 (273) alignment 
Range on Protein: 19-147
Range on HMM: 132-261/273.0
MILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINK
.. |.. . ||.|||...|. |..|..|..|| .  ||... |.|   |  .... .|  ||.. .....  .|. .|||||. |||...|.|. . .. 
ltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldq

CKTEGVIDVFQVLKSQRIQKPGSVQTVDRI
 ..|| .||....|  | |.||.|||.. .
lekeggvdvleavkllrsqRpgmvqtpeqy
0051299 (Phosphotyrosine protein) phosphatases II 19-146 3.1e-27 91.2 In-house 144-274 (288) alignment 
Range on Protein: 19-146
Range on HMM: 144-274/288.0
MILGEYNIILLNEETFNGYIERKFEVKNN----NTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATT
...|.. . ||.||....|. |..||.|.     .| .. ||... |||   |  ..|. .|  ...... ..  |.  .|||||. |||...|.|. . 
ltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdll

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVDR
..  ..||..||....|  | |.||.|||.. 
leqlekeggvdvleavkrlreqRpgmvqtpeq
0040438 (Phosphotyrosine protein) phosphatases II 19-146 4.3e-27 90.6 In-house 138-264 (317) alignment 
Range on Protein: 19-146
Range on HMM: 138-264/317.0
MILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKC
.  |.. . ||.||. .|.. |..||...... .  ||... |.|.  |   .|...|  .|.. . .. .... ..||||. |||...|.|| . .. .
ltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleql

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
..|| .||....|  | |.||.||| . 
ekeggvdveeavkelreqRpgavqtpeq
0042113 (Phosphotyrosine protein) phosphatases II 19-146 9.8e-25 82.8 In-house 104-231 (245) alignment 
Range on Protein: 19-146
Range on HMM: 104-231/245.0
MILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
.  |.. . ||.||....|. |..||.|. .. .. |..|. ..|.  |  ......| ..|.. . ... .|. ..||||. |||...|.|| . ..  
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
..|. .......|  | |.||.||| . 
ekelgvsleeavkelrsqRpgavqtpsq
0043336 (Phosphotyrosine protein) phosphatases II 19-146 1.1e-24 82.8 In-house 139-265 (278) alignment 
Range on Protein: 19-146
Range on HMM: 139-265/278.0
MILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKC
.  |.. . ||.||....|. |..||.|. .| .. ||.|. ..|   |  ......|  .... . ..   |. ..||||. |||...|.|. . ..  
ltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleql

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
..|| .|.....|  | |.||.||| . 
ekeggvdleeavkelreqRpgavqtpsq
0040439 (Phosphotyrosine protein) phosphatases II 19-145 1.8e-23 78.9 In-house 106-233 (249) alignment 
Range on Protein: 19-145
Range on HMM: 106-233/249.0
MILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINK
.  |.. . ||..|....|. |..|..|. .| .  |...|.|.|  .|   .....|  ||..   ...   .. ..||||. |||...|.|| . .. 
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

CKTEGVIDVFQVLKSQRIQKPGSVQTVD
 ..|. .|.....|  | |.||.||. .
lekelgvdleeavkllrsqRpgavqnpe
0045098 (Phosphotyrosine protein) phosphatases II 19-145 1.8e-22 75.5 In-house 116-259 (278) alignment 
Range on Protein: 19-145
Range on HMM: 116-259/278.0
MILGEYNIILLNEETFNGYIERKFEVKNN----NTGATQSVTQYQITNWDSTGKLTNP--QTILLVIEEMYRTQR------------KRGNTSIVVHCSD
.. |.. . ||.||... |. |...| |     ... .  ||......|.  |  ..|  . .| ..|.. . ..              ... ..|||| 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

TVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVD
 |||.....|| . .  .  ||..|.....|  | |.|| .||. .
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnle
subfamily_PTPRK_pd Subfamily PTPRK 19-146 8.3e-20 65.8 In-house 137-265 (314) alignment 
Range on Protein: 19-146
Range on HMM: 137-265/314.0
MILGEYNIILLNEETFNGYIERKFEVKN--NNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTIN
.. |. .. |.. |. . .. | | |..   .  ... | |.| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..
evygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivld

KCKTEGVIDVFQVLKSQRIQKPGSVQTVDR
  ..|||.|||.. |. | .|.  |.| ..
mieregvvdvfnavktlrsrkvnmveteeq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 19-145 1.7e-18 61.7 In-house 137-263 (281) alignment 
Range on Protein: 19-145
Range on HMM: 137-263/281.0
MILGEYNIILLNEETFNGYIERKFEVkNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
...|.. .  ..||. . ||||||.. ....| |..|.| . |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ....
lkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkav

KTE-GVIDVFQVLKSQRIQKPGSVQTVD
..|   .|| .|... | ..   |||| 
eaeleeldvkavvaelrkernlmvqtvv
subfamily_PTPRB_pd Subfamily PTPRB 19-147 7.1e-18 59.6 In-house 147-274 (293) alignment 
Range on Protein: 19-147
Range on HMM: 147-274/293.0
MILGEYNIILLNEETFNGYIERKFEVKNnnTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINK
.. |. .. |..||. . .. |......  . ....|.||. | |   |   ...|.|  .... ... ..  .. ||||||  |||.  | |  . ...
vlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqa

CKTEGVIDVFQVLKSQRIQKPGSVQTVDRI
 ..| ..|.| .. . | ..   |||... 
ieeedyvdifgivaelReeRnllvqtekqY
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 19-146 6.7e-16 53.1 In-house 143-267 (315) alignment 
Range on Protein: 19-146
Range on HMM: 143-267/315.0
MILGEYNIILLNEETFNGYIERKFEVKNNNtgATQSVTQYQITNWDsTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
.| |.. . . .|| .. |  | . |  ..    . | |...| |  . ....  . |. .    .  ..   ..||||||. |||.  |..  . ... 
viyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
..| .|||.....  | .. . ||....
eaenaidvynfitgvrqnrikmvqvaeq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 19-143 3.5e-08 27.4 In-house 148-268 (290) alignment 
Range on Protein: 19-143
Range on HMM: 148-268/290.0
MILGEYNIILLNEETFNG-YIERKFEVKNNNTGATQSVTQYQITNWDSTGkLTNPQtiLLVIeEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInK
. .||. ..  .|.. .   | . . |.. ..|    .  ..|  |     ... .  | ..  . |. ||  .  .|||||  .||.  | |  ... .
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valst..lall.rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.q

CKTEG-VIDVFQVLKSQRIQKPGSVQT
. ..|  .|. .. .. |  . .||| 
illdGkeldlldlvralrnsrlnsvqv
subfamily_PTPN23_pd Subfamily PTPN23 20-151 2.5e-18 60.9 In-house 138-273 (288) alignment 
Range on Protein: 20-151
Range on HMM: 138-273/288.0
ILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVI---EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
  |.... | .... . ..||..... ... |..||.  |.|.| . |    |.|.| ..   |..|...... .| .|||||  |||. .|.   . ..
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

KCK-TEGVIDVFQVLKSQRIQKPGSVQTVDRIIPDY
. .  .|..|. ||..  | |.  .||.....   |
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsy
subfamily_PTPN12_pd Subfamily PTPN12 20-146 8.6e-18 59.2 In-house 138-265 (290) alignment 
Range on Protein: 20-146
Range on HMM: 138-265/290.0
ILGEYNIILLNEETFN-GYIERKFEVKNNntGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKC
  ||... | .|.... ... | ..|...  .....|.|.. |.|   |  ......| .||.. ..|. . .. .|||||  |||    .|   . .  
efgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrell

KTEGV---IDVFQVLKSQRIQKPGSVQTVDR
|.| .   .|||... . | |..  ||| ..
kaekipeeldvfdlvlelrkqraalvqtkeq
subfamily_PTPN13_pd Subfamily PTPN13 20-151 2.4e-16 54.9 In-house 133-262 (273) alignment 
Range on Protein: 20-151
Range on HMM: 133-262/273.0
ILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCK
. . ... ||. .  .|.  |...||....|... |.. . ..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  .
vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglie

TEGVIDVFQVLKSQRIQKPGSVQTVDRIIPDY
 .  .|| ..... | |. | ||| |. |  |
rdkefdvkeivrklreqrqgvvqtkdqyifvy
subfamily_PTPN3_pd Subfamily PTPN3 20-145 8.9e-16 52.6 In-house 138-262 (280) alignment 
Range on Protein: 20-145
Range on HMM: 138-262/280.0
ILGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 .||... . .|.. . |. |.. .|...|   ....| | ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  
eygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalie

TEGVIDVFQVLKSQRIQKPGSVQTVD
..  . . ....  | |.   |||..
aaepvypldivrtmrdqramlvqtas
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 20-148 2.2e-11 38.5 In-house 99-229 (237) alignment 
Range on Protein: 20-148
Range on HMM: 99-229/237.0
ILGEYNIILLNEETFNGYIERKFEVKNNNTG-ATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINK
  | . . |  .| |  |  | . . .. |    . . |||.| |   |   .  ..|    ..    ..    .  ..|||  |||...|    . . .
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

CKTEGVIDVFQVLKSQRIQKPGSVQTVDRII
.| . |.|... ..|   ..|  .|| |. .
akekkvvdiynyvysieedrpyiiqtkdqyv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 21-146 1.1e-34 115.0 In-house 145-271 (305) alignment 
Range on Protein: 21-146
Range on HMM: 145-271/305.0
LGEYNIILLNEETFNGYIERKFEVKN-NNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
.||....| .|.|...|||||... . ..   ...|.|||.|.|   |  . . ..| .|... ..|.|  .....||||..|||. .|.|    ....|
fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlk

TEGVIDVFQVLKSQRIQKPGSVQTVDR
.|.|.|||.|||  | .... ||| |.
kEevvdvfevlkqlRskrmkmvqtldq
subfamily_PTPRD_pd Subfamily PTPRD 21-146 1.3e-28 94.9 In-house 145-269 (564) alignment 
Range on Protein: 21-146
Range on HMM: 145-269/564.0
LGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 ||. . | .||... |. |.|..|....  .. |.|.. |.| ..|  ......| .|... ... ....  ||||||  |||. .|..    ... |.
ygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerike

EGVIDVFQVLKSQRIQKPGSVQTVDR
|...|..|..|  | |..  ||| . 
ektvDiyqyvkalrkqRnamVqteeQ
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 21-146 1.4e-26 88.0 In-house 129-254 (283) alignment 
Range on Protein: 21-146
Range on HMM: 129-254/283.0
LGEYNIILLNEETFNGYIERKFEVKNN-NTGATQSVTQYQITNWDSTGKLTNPQTiLLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 ||. . | .| | | .| ... ...|  . .|  .. ||. .| . |. .   . |. .. .   |..  .. |||||| ..||.|.|.||...... .
yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

TEGVIDVFQVLKSQRIQKPGSVQTVDR
|| |.|||.|.|  | |... ||| |.
tesvvdvfavvkimreqrmmavqtldq
DSPc_SM00195 21-145 4.7e-25 83.8 In-house 125-249 (263) alignment 
Range on Protein: 21-145
Range on HMM: 125-249/263.0
LGEYNIILLNEETFN-GYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCK
 |.... | ..|. .  .| |..|......  |..|||||..||   |   ... .| ...... ....  .. ||||||. |||...|... . ..|..
fgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskle

TEGVIDVFQVLKSQRIQKPGSVQTVD
.|  .|.|...|. | |.||.||| .
eekkvdifeivkelRkqRpgmvqtle
PTPc_SM00194 21-145 4.7e-25 83.8 In-house 125-249 (263) alignment 
Range on Protein: 21-145
Range on HMM: 125-249/263.0
LGEYNIILLNEETFN-GYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCK
 |.... | ..|. .  .| |..|......  |..|||||..||   |   ... .| ...... ....  .. ||||||. |||...|... . ..|..
fgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskle

TEGVIDVFQVLKSQRIQKPGSVQTVD
.|  .|.|...|. | |.||.||| .
eekkvdifeivkelRkqRpgmvqtle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 21-154 7.7e-24 79.2 In-house 105-238 (250) alignment 
Range on Protein: 21-154
Range on HMM: 105-238/250.0
LGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 |.  . ||..|.|  |. ||. . ...    . | |.. ..|   |   . ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVIDVFQVLKSQRIQKPGSVQTVDRIIPDYFMI
| |.|||.|.|  |...|..|.. .. .  | .|
ekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 21-155 2.2e-23 77.9 In-house 146-281 (325) alignment 
Range on Protein: 21-155
Range on HMM: 146-281/325.0
LGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVI---EEMYRTQR--KRGNTSIVVHCSDTVGRSAMFCAAATTI
.|  .. |   |..  |. |...||. . | |.|| |.|.  ||  |    | |.. ..   ...  . .   .. | |.||||. |||. .| .  . .
fGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysal

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVDRiipdYFMIY
.|  .|  .|.|...|  | ..|  |.|||.    | .||
akvieesrvdifgfvkklrkdrpsmvetvdq....yiliy
subfamily_PTPRA_pd Subfamily PTPRA 21-153 4.5e-21 70.1 In-house 155-290 (330) alignment 
Range on Protein: 21-153
Range on HMM: 155-290/330.0
LGEYNIILLNEETFNGYIERKFEVKN----NNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTIN
 |. .. . .|.  . |  ||| |..     .  ... |.|.  | |   |  ..|. .| ..... ..... .. .||||||  |||.  |..  . ..
yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

KCKTEGVIDVFQVLKSQRIQKPGSVQTVDRIIPDYFM
. |.|...|||...|. | |.|  |||  .    | .
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 21-146 1.5e-19 65.3 In-house 145-272 (297) alignment 
Range on Protein: 21-146
Range on HMM: 145-272/297.0
LGEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
.|.  ..||  .  .|.|.|..||..... |.. | ||| ..| .       . ...| .|.|.  .  .. .. ..|||.  ||| .....    . . 
fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
| |  .|.|...|  | ..|  ||| . 
krekevdifglvkklrqerpylvqtkeq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 21-146 3e-19 64.0 In-house 143-265 (315) alignment 
Range on Protein: 21-146
Range on HMM: 143-265/315.0
LGEYNIILLNEETFNGYIERKFEVKNNNtgATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
.|.... ||. |.  . . ||. ... .  ... |||.| |.|   |   .  ..| .| |.    ... . |..||||  |||. .....   ... | 
fGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikr

EGVIDVFQVLKSQRIQKPGSVQTVDR
. ..|||...|  | ..|  ||| ..
trsvdvfnfvknlrakrpylvqteee
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 21-147 5.7e-19 63.2 In-house 145-268 (288) alignment 
Range on Protein: 21-147
Range on HMM: 145-268/288.0
LGEYNIILLNEETFNGYIERKFEVKnnNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 |. ...|..... . ...||....   ..    .|||| . |  .|   . . .| ... .  .. .     |.||||. |||.  | |. . |.. ..
yGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidavee

EGVIDVFQVLKSQRIQKPGSVQTVDRI
| .|||. ...  | |..  |||. . 
edyiDvagtvaklRkqRallvqtlkqY
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 21-146 9.7e-19 61.8 In-house 142-264 (515) alignment 
Range on Protein: 21-146
Range on HMM: 142-264/515.0
LGEYNIILLNEETFNGYIERKFEVKNNNTgaTQSVTQYQITNWDSTGKLTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
.|.... |.  |.  | | ||..|  ..   .. |||.. |.|   |   . ...| .| |. .... . . ....|||  |||  .....   . . ||
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakt

EGVIDVFQVLKSQRIQKPGSVQTVDR
  ..|||....  | ..|  ||| ..
trmvdvfnfvtnirqkrpylvqtqeq
subfamily_PTPN6_pd Subfamily PTPN6 21-155 5.3e-17 56.8 In-house 153-290 (306) alignment 
Range on Protein: 21-155
Range on HMM: 153-290/306.0
LGEYNIILLNEETFNGYIERKFEVK-NNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTIN
 |....  ..|.. . || |.. |. ... . ...| ||. ..|   |  ..|...|  .|.. | |..     . .||||||. .||   |    . ..
yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillk

KCKTEGV---IDVFQVLKSQRIQKPGSVQTVDRiipdYFMIY
. ...|.   ||. .. || | |. | ||| .     | ..|
liekkgldadidiqklvksvreqrsglvqteqq....ykfvy
subfamily_PTPRG_pd Subfamily PTPRG 21-145 2.3e-16 54.1 In-house 145-274 (563) alignment 
Range on Protein: 21-145
Range on HMM: 145-274/563.0
LGEYNIILLNEETFNGYIERKFEVKNNNTGAT------QSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATT
.|. .. | .||..  | .|.. .|| .  ..      . |.||. |.|  .|  . .   |  ..   .....     ||||||  |||. ....  | 
ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtl

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVD
... ..| ...||..||  | |..  ||| .
lkqiqqenavnvfgflkhiraqRnflvqteE
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 22-153 1.4e-27 91.8 In-house 154-285 (298) alignment 
Range on Protein: 22-153
Range on HMM: 154-285/298.0
GEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
|| .. ||..|.|  .| ||..|.....  ...| | . |.| . |  .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.|
geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkke

GVIDVFQVLKSQRIQKPGSVQTVDRIIPDYFM
 |.|||||.|  |...||.||| .. .  | .
qvvDvfqvvkvlRkkrpgavqteeqYvfiyea
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 22-183 5.5e-26 86.4 In-house 146-310 (319) alignment 
Range on Protein: 22-183
Range on HMM: 146-310/319.0
GEYNIILLNEETFNGYIERKFEVKNNNTGA-TQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
|.. . |..||  ..|| ||........   | .|...| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |..   .... | 
GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervke

EGVIDVFQVLKSQRIQKPGSVQTVDR--IIPDYFMIYASQFYDKDENDDVNDTIDALWCQSANNG
|||.|||.. .  |.|..  ||. .   .| .  . ... .  . | .|..| . .|  . |. |
egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtg
Y_phosphatase Protein-tyrosine phosphatase 22-146 1e-25 85.9 Pfam-A 99-225 (235) alignment 
Range on Protein: 22-146
Range on HMM: 99-225/235.0
GEYNIILL-NEETF-NGYIERKFEVKNNNTG-ATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
|.... |  .|..  ..|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
..|. .||.|..|. | |.||.||... 
eaeeevdvlqivkelRkqRpgmvqsleq
Y_phosphatase Protein-tyrosine phosphatase 22-146 1e-25 85.9 In-house 99-225 (235) alignment 
Range on Protein: 22-146
Range on HMM: 99-225/235.0
GEYNIILL-NEETF-NGYIERKFEVKNNNTG-ATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
|.... |  .|..  ..|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEGVIDVFQVLKSQRIQKPGSVQTVDR
..|. .||.|..|. | |.||.||... 
eaeeevdvlqivkelRkqRpgmvqsleq
subfamily_PTPN9_pd Subfamily PTPN9 22-147 9.1e-15 49.4 In-house 142-279 (297) alignment 
Range on Protein: 22-147
Range on HMM: 142-279/297.0
GEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFC
|....  .. |. . | .|..|.|| .|. ...|| .|.. |   |   . ...| |.|.. ..|          ..|   .  ||||||  .||.  |.
gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfi

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVDRI
.   .... ...|..||....|  | |.  |.|| .. 
tldiclsrleevgtvdvvetvkllrtqrafsiqtpeqy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 22-147 1.5e-13 45.4 In-house 123-253 (270) alignment 
Range on Protein: 22-147
Range on HMM: 123-253/270.0
GEYNIILLNEETFNGYIERKFEVKnnNTGATQSVTQYQITNWDSTGKLT------NPQTILLVIEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATT
|. ... |.||  .||| .. ...  ..| .. .. .. ..|   |  .      ... .| ..... |....  . . ..||||. |||. .. |  ..
gkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDia

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVDRI
..  .... .|| ....  | ...  ||.....
vrlLeetkkvdvlaiieelRkdRmalvqhpeqy
subfamily_PTPN14_pd Subfamily PTPN14 22-144 6.6e-09 30.2 In-house 152-282 (300) alignment 
Range on Protein: 22-144
Range on HMM: 152-282/300.0
GEYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNT--------SIVVHCSDTVGRSAMFCAAAT
|.....    |. . .| .....|   ..  ..|   | |.|   |   .... |  .||.   .||  ..         ..||||. |||. .   .  
gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 |.  ... .||. .||.  | |.   |||.
liatlehneeidikkvlarLreqrmllvqtl
subfamily_PTPN1_pd Subfamily PTPN1 23-154 5e-15 50.0 In-house 132-267 (290) alignment 
Range on Protein: 23-154
Range on HMM: 132-267/290.0
EYNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KC
.... |..||. . |. |..|..| .|  |......  | |   |    |.. |  . .. ..   ..     |.|||  .|||  || . | .    | 
klkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekk

KTEGVIDVFQVLKSQRIQKPGSVQTVDRIIPDYFMI
.    .|. .||   | .. | .|| |..   |. |
ddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPRN_pd Subfamily PTPRN 23-146 1.4e-14 48.5 In-house 156-280 (297) alignment 
Range on Protein: 23-146
Range on HMM: 156-280/297.0
EYNIILLNEETF-NGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KT
 |.. |. |  . . |. | | .|| .|  |..|||.    | ..|  ......|     . .. | |  ..||||||| .||. ....    .|.  | 
iyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkG

EGVIDVFQVLKSQRIQKPGSVQTVDR
   ||.   |.  | |.|| |.| |.
vkeidiaatlehlrdqrpglvktkdq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 24-183 2.2e-27 91.0 In-house 146-307 (318) alignment 
Range on Protein: 24-183
Range on HMM: 146-307/318.0
YNIILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV
  . | .| ... |. |.|.|..... ... | ||..|.|  .| .... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |..
lvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal

IDVFQVLKSQRIQKPGSVQTVDRI--IPDYFMIYASQFYDKDENDDVNDTIDALWCQSANNG
.||||. |  | |..  ||| |.   | |  . .   .  . . .|... |  |  |... |
vDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesg
0051082 (Phosphotyrosine protein) phosphatases II 24-154 9e-11 37.1 In-house 35-149 (151) alignment 
Range on Protein: 24-154
Range on HMM: 35-149/151.0
YNIILLNEETFNGYIERKFEVKNnntgatQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegv
. |. |..|. .||  . ..  .        |....|..|. .|  ......| ..|.. .     .|  ..||||  .||.....|.   . .      
ktivnlrseeergycpeylpelg......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......

IDVFQVLKSQRIQKPGSVQTVDRIIPDYFMI
......|.  |.. ||.||. . ..  .|..
vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Ptp69D_pd Subfamily Ptp69D 25-154 3.5e-19 64.1 In-house 149-282 (307) alignment 
Range on Protein: 25-154
Range on HMM: 149-282/307.0
NIILLNEETFNGYIERKFEVKNNN-----TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCK
.. | .||. . ||.|...| ...       ... |.||. |.|. .     ....| .||...  ...  .. ||||||  ||||..| | .  ....|
lvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlk

TEGVIDVFQVLKSQRIQKPGSVQTVDRIIPDYFMI
.|  .|.|.. |  | |..  ||  .  .  |  .
aedkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 26-147 2e-11 38.5 In-house 109-229 (239) alignment 
Range on Protein: 26-147
Range on HMM: 109-229/239.0
IILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID
. | . | |  || | | . .      . | ||..| |   |      | .| .      .   |    |.|||  |||.  |    . . ..| .  .|
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd

VFQVLKSQRIQKPGSVQTVDRI
.|. .|. | ..|  ||| .. 
ifnyvkairedrphmvqtseqy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 26-147 2.1e-11 38.5 In-house 110-230 (239) alignment 
Range on Protein: 26-147
Range on HMM: 110-230/239.0
IILLNEETFNGYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID
. | . | |  || | | . .      . | ||..| |   |      | .| .      .   |    |.|||  |||.  |    . . ..| .  .|
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd

VFQVLKSQRIQKPGSVQTVDRI
.|. .|. | ..|  ||| .. 
ifnyvkairedrphmvqtseqy
0049260 (Phosphotyrosine protein) phosphatases II 26-145 2.1e-11 39.2 In-house 37-137 (152) alignment 
Range on Protein: 26-145
Range on HMM: 37-137/152.0
IILLNEETFNGYIERKFEVknnntgatqsvtQYQITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVID
|. |.|.. .|..  ..              ||. ..|.  |  ...| .| ... . .  ... .  ..||||  |||.....||   .        ..
ivmltellelgklkceqyi............qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvs

VFQVLKSQRIQKPGSVQTVD
......  | ..||.|.. .
leeavalvrekRpgavpnpg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 29-148 4.7e-37 122.3 In-house 166-283 (301) alignment 
Range on Protein: 29-148
Range on HMM: 166-283/301.0
LNEETFNGYIERKFEVKNNNtgATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQ
... . ||||||||.||...  ....|.|.|.|.|   | . .|.|.| ||...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||
iqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfq

VLKSQRIQKPGSVQTVDRII
| |. | .||| |.| .  .
vtkavrrskpgaVtTLeqyt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 30-146 1.6e-16 55.2 In-house 140-256 (274) alignment 
Range on Protein: 30-146
Range on HMM: 140-256/274.0
NEETFNGYIERKFEVKNNNTgaTQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVF
.  . |.|  ||. .|. .   ..||. |  |.|  .    ...|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||.
kiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

QVLKSQRIQKPGSVQTVDR
..    |... | ||| ..
kivcnlrldrGGmvqtseq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 31-156 4.8e-17 57.2 In-house 163-285 (319) alignment 
Range on Protein: 31-156
Range on HMM: 163-285/319.0
EETFNgYIERKFEVKN-NNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQ
||| . |. |..|. .  .    ...||. .  |   |.   |  .. ...   . |........||||||  |||. .. .  . ... | |  .||..
eetae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvyn

VLKSQRIQKPGSVQTVDriipDYFMIYA
...  | |..  || .     .|..||.
fvrdlrqqrntlvqdlv....qykfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 31-156 5.6e-17 57.1 In-house 127-249 (284) alignment 
Range on Protein: 31-156
Range on HMM: 127-249/284.0
EETFNgYIERKFEVKN-NNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQ
||. . |. |..|. .  .    ....|. .  |   |.   |  .. ...   . |........||||||  |||. .. .  . ... | |  .||..
eesee.yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvyn

VLKSQRIQKPGSVQTVDriipDYFMIYA
...  | |..  || .     .|..||.
fvrdlrqqrntlvqdlv....qykfiys
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 32-139 1.2e-07 26.2 In-house 138-240 (290) alignment 
Range on Protein: 32-139
Range on HMM: 138-240/290.0
ETFNGYIERKFEVKNNNtGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVL
|. .. ..|. .|| .. .    || ... .|...    ...|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .||
ekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvl

KSQRIQKPG
|. | |.  
kalrkqral
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 35-148 2.3e-17 57.9 In-house 139-249 (267) alignment 
Range on Protein: 35-148
Range on HMM: 139-249/267.0
NGYIERKFEVKNNNTGAtQSVTQYQITNWDSTGKltNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQR
| |    .|.| .|  | . || |   .|.   .  |   .  ..  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  |
ndyqiitlelkfknesa.hnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkir

IQKPGSVQTVDRII
 |..| |.| .| |
sqriglvdtkeryi
0049772 (Phosphotyrosine protein) phosphatases II 35-151 1.2e-07 27.2 In-house 167-273 (314) alignment 
Range on Protein: 35-151
Range on HMM: 167-273/314.0
NgyierkfEVKNNNTGATQSVTQYQITNWDStGKLTNPQTILLVIEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQR
.       |. ...   .. . .|  ....  |    .. .. ..| . .    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  |
k.......eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvr

IQKP-----GSVQTVDRIIPDY
 . |     |.... .. .  .
lkRpinpnpgfieqleqyefil
0048076 (Phosphotyrosine protein) phosphatases II 36-145 2.1e-11 39.2 In-house 28-130 (145) alignment 
Range on Protein: 36-145
Range on HMM: 28-130/145.0
GYIERKFEVKNNNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRI
  | . . . .. .. .. ..||. ..|.  |  . ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | 
lgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrs

QKPGSVQTVD
| ||.|....
qrpgavpnpg
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 36-148 3.3e-07 24.1 In-house 155-269 (439) alignment 
Range on Protein: 36-148
Range on HMM: 155-269/439.0
GYIERKFEVKNN--NTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQ
 |. | | | |.  .|   ..| |.. . |      ..   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  
nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvl

RIQKPGSVQTVDRII
| |.   ||.. . .
rkqrkqmvqalcqyv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 41-146 3.2e-12 40.6 In-house 266-373 (392) alignment 
Range on Protein: 41-146
Range on HMM: 266-373/392.0
KFEVKNNNTGATQSVTQYQITNWDSTGKLT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
|   . ... |. .|||||.  |   |       ...| .|  .  .  .. . ||.|||    ||. .||.|   | .      .|.|| .|  | .. 
kqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrm

GSVQTVDR
 .||| . 
qfvqteee
0046846 (Phosphotyrosine protein) phosphatases II 44-145 1.8e-09 33.1 In-house 77-160 (176) alignment 
Range on Protein: 44-145
Range on HMM: 77-160/176.0
VknnntgatqsvtQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKrGnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQ
.            ||. ..|.  |  .  . .| ..|.... ... |   ..||||  .||.....||      ...|  ..|...|.  | |.| |.||
i............qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TVD
| .
tpe
0043147 (Phosphotyrosine protein) phosphatases II 45-145 4.6e-13 44.7 In-house 55-148 (172) alignment 
Range on Protein: 45-145
Range on HMM: 55-148/172.0
KNNNTGATQSVTQYQITNWDSTGKLtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQT
 .. .. .... ||. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqn

VD
 .
ps
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 45-148 4.9e-08 26.8 In-house 178-278 (302) alignment 
Range on Protein: 45-148
Range on HMM: 178-278/302.0
KNNN--TGATQSVTQYQITNWDSTGKLTNPQTILLVIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
||..  .   ..|   . . |   |   ...| | ..   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||
knekkkkkvkktvdilafsawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavq

TVDRII
. ...|
deqqli
0048179 (Phosphotyrosine protein) phosphatases II 46-145 2.4e-10 35.8 In-house 48-132 (144) alignment 
Range on Protein: 46-145
Range on HMM: 48-132/144.0
NnntgatqsVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVD
.        ..||. ..|.  |  . .. .| ..| . . ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. .
e........giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 46-144 3.8e-06 21.2 In-house 86-190 (199) alignment 
Range on Protein: 46-144
Range on HMM: 86-190/199.0
NNNT--GATQSVTQYQITNWDST--GKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKP
|| |   .|. ...||.| |      ...    ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . 
nnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarc

GSVQTV
| . ..
giissl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 46-144 3.8e-06 21.2 In-house 85-189 (198) alignment 
Range on Protein: 46-144
Range on HMM: 85-189/198.0
NNNT--GATQSVTQYQITNWDST--GKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKP
|| |   .|. ...||.| |      ...    ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . 
nnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarc

GSVQTV
| . ..
giissl
0044763 (Phosphotyrosine protein) phosphatases II 47-143 8.8e-08 27.5 In-house 75-156 (178) alignment 
Range on Protein: 47-143
Range on HMM: 75-156/178.0
NntgatqsvTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
.         ||. ....  |  . .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
g........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 47-144 2.1e-07 25.3 In-house 170-263 (307) alignment 
Range on Protein: 47-144
Range on HMM: 170-263/307.0
NNTGATQSVTQYQITNWDSTGkltNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTV
. .. .......| .||   |    ||. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| 
dwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqte
0036282 (Phosphotyrosine protein) phosphatases II 48-144 6e-15 50.8 In-house 62-156 (174) alignment 
Range on Protein: 48-144
Range on HMM: 62-156/174.0
NTGATQSVTQYQITNWDSTGKLTNPQtILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTV
 .  .... ||. ..|.  |  . .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.||| 
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp
subfamily_CG7180_pd Subfamily CG7180 49-146 2.5e-13 44.3 In-house 176-278 (296) alignment 
Range on Protein: 49-146
Range on HMM: 176-278/296.0
TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.  |  |...|.| |..  |.    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..
kaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

VDR
|. 
vee
0041856 (Phosphotyrosine protein) phosphatases II 49-159 9e-12 40.4 In-house 73-172 (182) alignment 
Range on Protein: 49-159
Range on HMM: 73-172/182.0
TGATQSVTQYQITNWDSTGKLTnPQTILLVIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTVDRII
.  .. ..||. ..|.  |  . ....|  |||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.| . ..
ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyf

PDYFMIYASQF
  . ...  . 
flqlallelll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 51-148 3.2e-06 21.4 In-house 114-211 (255) alignment 
Range on Protein: 51-148
Range on HMM: 114-211/255.0
ATQSVTQYQITNWDSTGKLTNPQTILLVieemYRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQT
 |. |. |. . |       ... || .    ..  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......|
kthtvkhysykGWieknaPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraiht

VDRII
  .. 
Plqla
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 52-146 6.7e-11 36.2 In-house 88-182 (440) alignment 
Range on Protein: 52-146
Range on HMM: 88-182/440.0
TQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVDR
.... ||.   |   |       .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 54-114 2.4e-06 21.5 In-house 216-285 (350) alignment 
Range on Protein: 54-114
Range on HMM: 216-285/350.0
SVTQYQITNWDSTGKLTNPQTILLVIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATT
 | | |. ||   . | ||. || ..|         . .   . .|. ..|.||||  |||  ....    
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsl
PTPc_DSPc_SM00012 55-147 9.6e-20 66.1 In-house 2-96 (105) alignment 
Range on Protein: 55-147
Range on HMM: 2-96/105.0
VTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVDRI
|..|..|.|  .|. .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| .  
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 58-156 3e-06 20.9 In-house 186-279 (302) alignment 
Range on Protein: 58-156
Range on HMM: 186-279/302.0
YQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVDRiipdYFMIYA
| .||| ..  ...  ..   .....  .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|....     | ..| 
yvltnWkqkkvpvkyaeliktaakvfakk.ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQ....yvslyi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 81-146 2.1e-06 21.8 In-house 219-283 (297) alignment 
Range on Protein: 81-146
Range on HMM: 219-283/297.0
EMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVDR
| .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||...
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleq
fn3 Fibronectin type III domain 584-667 4.4e-14 45.6 Pfam-A 2-83 (85) alignment 
Range on Protein: 584-667
Range on HMM: 2-83/85.0
PVGDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGEDNrMYNLTGLVPYTNYTVSIIPYNYNMNGP
..... .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 688-761 1.4e-14 47.2 Pfam-A 9-84 (85) alignment 
Range on Protein: 688-761
Range on HMM: 9-84/85.0
YAKNPDAISIVWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYSIVGLIPNTSYTIEVRAYTSIGPGEW
 . ... ... |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|...|.|..  | |..
sevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
I-set Immunoglobulin I-set domain 832-920 7.8e-14 43.2 Pfam-A 1-90 (90) alignment 
Range on Protein: 832-920
Range on HMM: 1-90/90.0
PVIEEFPNDMTSEEGRQVLFKVKvkVRGNSKPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVSQQVVLTV
|.... ..|.. .|| .| ....  |.|. .||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelect..veGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
Ig_3 Immunoglobulin domain 832-907 3.5e-06 19.1 Pfam-A 2-75 (75) alignment 
Range on Protein: 832-907
Range on HMM: 2-75/75.0
PVIEEFPNDMTSEEGRqvlFKVKVKVRGNS-KPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHKGTYRFVANN
|||   |. .....|     ..   ..|.. .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
Pvisvspsptvtsggn...vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 857-920 6.2e-06 18.2 Pfam-A 23-80 (80) alignment 
Range on Protein: 857-920
Range on HMM: 23-80/80.0
VRGNSKPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANND-AGTVSQQVVLTV
..|| .|.. ||..||...   .        |.. .|.....|||. .| |.  ...|. | .||
apgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
0050432 (Phosphotyrosine protein) phosphatases II 932-1095 9.2e-43 142.1 In-house 15-174 (308) alignment 
Range on Protein: 932-1095
Range on HMM: 15-174/308.0
HGDSSSAKIDMIPVDKFGEFVANghAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmpghkDCTNEYINACFIKDY--S
...| ...   ..|... ... .  |... ... .|  | |   ... .|.| | || .||. .|. || .|. |       | .. |||| ... |   
rdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssk

NQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS---DTKDYGPFSVTLRE
.. ..|||||| .||. |||...|......|||.|...| |..|| ||||..   ... ||.|.|||..
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtlls
subfamily_PTPRA_pd Subfamily PTPRA 936-1095 2.1e-38 127.1 In-house 7-164 (330) alignment 
Range on Protein: 936-1095
Range on HMM: 7-164/330.0
SSAKIDMIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDctNEYINACFIKDYSNQYQYI
.. |   .||.|. | .    |  |. ||..|  | .|. . |. .     ||  ||. ||. || .|. | .. |...   .|||| ||. | .. ..|
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykekdkfi

ATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
|.||| ..|. |||..||. ||. |||.|.. |  . ||.||||.  .  ||   |....
aaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirveved
subfamily_PTPRB_pd Subfamily PTPRB 941-1094 8.6e-43 141.4 In-house 5-157 (293) alignment 
Range on Protein: 941-1094
Range on HMM: 5-157/293.0
DMIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGP
  | ..|| |.|.. .|. . .| ... .| . ..|..|..  .. |.  ||. ||. || .|. | .. ...  ...|||| .|..|. . ..||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdes..gsDYinanyipgynsprefiatqGP

VSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS-DTKDYGPFSVTLR
. .|. |||...|..||.||||.|...|.|||||..|||.  ..  ||  .||| 
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 942-1094 4.6e-88 289.8 In-house 1-153 (290) alignment 
Range on Protein: 942-1094
Range on HMM: 1-153/290.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCTNEYINACFIKDYSNQYQYIATQGPV
.|||||||||||||||||||||||||.|||||||.||||||||.|||||||||||||||||||||||..|||||||||||||.||.|....|||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLR
||||||||.||||||.|||||.||||||||||||||||.||||.||.||..| 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 942-1095 2.6e-60 198.8 In-house 1-149 (287) alignment 
Range on Protein: 942-1095
Range on HMM: 1-149/287.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDS-GESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmpghkDCTNEYINACFIKDYSNQYQYIATQGP
.|||.|||||||.|||||||||.||| .|.. ..... ||......|| .||...|.|.|..|. |.      .. ..||||.||. |......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
..||...||.||.... |.|||...  |. . .| ||||....  .|.....| .
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeynielln
subfamily_PTPRD_pd Subfamily PTPRD 942-1095 7.4e-51 168.4 In-house 4-154 (564) alignment 
Range on Protein: 942-1095
Range on HMM: 4-154/564.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGeSDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCtnEYINACFIKDYSNQYQYIATQGPV
 |||... |.||. .|...  | ...  ...| . .|...   | ||  ||.|||| || .|. |....|....  .|||| ||. | .. .|||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

SNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
..|. |||...|...|..|||.|.. |.|||||..|||...|. || . ||| |
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtlee
0051299 (Phosphotyrosine protein) phosphatases II 942-1095 9.1e-46 152.0 In-house 4-155 (288) alignment 
Range on Protein: 942-1095
Range on HMM: 4-155/288.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGhkDCTNEYINACFIKDYSNQYQYIATQGPV
 |.|... ..| . .|.|. |....| .| |   |.|....| | |.  ||. .|. ||..|. |....|  . .. |||| .|. | .. ..|||||| 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

SNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
.||. |||...|......|||.|...| |..|| ||||..... ||...|||..
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtlls
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 942-1095 2.2e-41 137.0 In-house 3-154 (305) alignment 
Range on Protein: 942-1095
Range on HMM: 3-154/305.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGesDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGPV
.| .|.. ... . ... ..|. .|. .| .   .... || .  ||  ||...|...||.|| |.. . ..   ..||||.... |... .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

SNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTK--DYGPFSVTLRE
 ||..|||.||..|| . |||.|...|.|| ||.||||.| |.  ..|.|||.|..
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelks
0045450 (Phosphotyrosine protein) phosphatases II 942-1094 1.1e-37 125.8 In-house 8-170 (307) alignment 
Range on Protein: 942-1094
Range on HMM: 8-170/307.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGES--DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkDCTNEYINACFI--------KDYSNQ
.|.. |.  .|.  ......|.. .| .| | .    .. ...| | || .||. .|. ||..|. | ...|. . .. |||| ..        . | ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSD-TKDYGPFSVTLR
 ..|||||| ..|. |||...|....|.|||.|. .| |..|| ||||... .. ||.| |||.
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 942-1095 2.3e-33 110.5 In-house 5-154 (315) alignment 
Range on Protein: 942-1095
Range on HMM: 5-154/315.0
MIPVDKFGEFVANGHAKGNEGFRNQFGMLDSGEsDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrPMPgHKDCTNEYINACFIKDYSNQYQYIATQGPV
 ||.|..  .||. .|  ..||....  .  |.  | . |     ||  ||. ||. ||  |. | |.   .|   .|.|| ||. |. . .|||.||| 
pipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidGynkkrryiaaqgpn

SNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSdTKDYGPFSVTLRE
 ... |||.|...|. . |||.||..|. | |...|||.     ||...||...
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrks
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 942-1083 2.1e-22 74.1 In-house 3-147 (392) alignment 
Range on Protein: 942-1083
Range on HMM: 3-147/392.0
MIPVDKFGEFVANGHAkgNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDctNEYINACFIKDYSNQYQYIATQGPV
 ||| .|  || . .   .  | ..|  | . .  .  ||. .. |.  ||. ||. || .|. |  .    |  ..|.|| .|. . |.  |||.||| 
pipvaqfpafveknrh..salffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpn

SNTLVDFWQLIWQEKSTIIVMITNIIEEGK----VKCQQY----WPNSDT
. .| |||....||. | |.|.|.. |  |      . |.    ||..| 
aaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdv
subfamily_PTPRG_pd Subfamily PTPRG 943-1095 7.7e-46 151.4 In-house 1-154 (563) alignment 
Range on Protein: 943-1095
Range on HMM: 1-154/563.0
IPVDKFGEFVANGHAKGNEGFRNQFGMLDS--GESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCTnEYINACFIKDYSNQYQYIATQGP
.||..| . ||. ||.|. || ..|  | |   ..| ...    |.||  ||  ||| ||  |..|.|.||.|.   .|||| .|. |  . ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
. .|. |||..||.....|||||||. |.|. ||..|||. ....|| ..||| |
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlie
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 943-1095 3.8e-43 142.7 In-house 2-152 (318) alignment 
Range on Protein: 943-1095
Range on HMM: 2-152/318.0
IPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGPVS
|.|... . |.. ...|.  . ... .|.  |.  | .  |.| ||  ||.|||. ||. |. |... |..  . .|||| .|  | .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlp

NTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
.|. |||...|. .|..|||.|.. |.||.|...|||..... ||   |.|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelke
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 943-1095 3.4e-41 136.3 In-house 5-154 (319) alignment 
Range on Protein: 943-1095
Range on HMM: 5-154/319.0
IPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDhTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCtnEYINACFIKDYSNQYQYIATQGPVS
|.|... | . . ...|. .....| .|. ...| |..   .. ||  ||. ||. ||  |..| ...| ..   .|||| ||  | .. ..||||.|..
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaPle

NTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
||. |||...|.|.| |.||.|.. |..|||...|||. . ..|| . ||| |
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtlee
subfamily_Ptp69D_pd Subfamily Ptp69D 943-1092 8e-39 128.6 In-house 4-151 (307) alignment 
Range on Protein: 943-1092
Range on HMM: 4-151/307.0
IPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCtnEYINACFIKDYSNQYQYIATQGPVS
|..|.  | . . . . ..|. . . .| . |.|.. .|.    |.| ||. .|. .|..|. |....|..|   .|||| ||| | .. ..|| |.|| 
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPve

NTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVT
.|. |||..|.. ..|.|||..|. |  . ||..|||. |.. ||   |.
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvk
0043336 (Phosphotyrosine protein) phosphatases II 943-1095 1.6e-38 128.2 In-house 2-150 (278) alignment 
Range on Protein: 943-1095
Range on HMM: 2-150/278.0
IPVDKFGEFVANGHAKGNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDctNEYINACFIKDYSNQYQYIATQGPVS
|.| .. ..... ..... .....|  |.|     | ...| | || .||. .|. || .|. | ...|. |  . |||| ... |. . ..|||||| .
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlp

NTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPnSDTKDYGPFSVTLRE
.|. |||...|....|.|||.|.  | |.|||.|||| .... ||.|.|||..
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 943-1093 8.6e-31 101.9 In-house 3-150 (315) alignment 
Range on Protein: 943-1093
Range on HMM: 3-150/315.0
IPVDKFGEFVANGhaKGNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDYSNQYQYIATQGPVS
||| .|  || .   .    | ..|  |   .  .  .|. .. |   ||. ||. .| .|. |  .   ..  ..|||| .|| . ..  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlk

NTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN--SDTKDYGPFSVTL
 .. |||....||| | |||.|.  |. |.||.||||.  .|. ..| ..|.|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 943-1093 1.2e-27 91.8 In-house 10-152 (297) alignment 
Range on Protein: 943-1093
Range on HMM: 10-152/297.0
IPVDKFGEFVANGHAkgNEGFRNQFGMLdsGES-DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKdySNQYQYIATQGPV
||. .|  .| ...    . |...|  |   |.  .. ||     |   .|..||. || .|..|. .   .|   .|.|| |.|  .|....|.|| | 
iplsdfatlvqknrh..tdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaiv..nddpdsDyvnasfvk..gnkhrlittqmPm

SNTLVDFWQLIWQEKSTIIVMITNIIEEGKvKCQQYWPNSDTKDYGPFSVTL
 .|. |||.....|. ..|||...  |. | ||..||... .. .|  ||.|
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 943-1039 3.4e-11 37.2 In-house 5-95 (95) alignment 
Range on Protein: 943-1039
Range on HMM: 5-95/95.0
IPVDKFGEFVANGHAKGNEGFRNQFGMLDSgESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmpGHKDctNEYINACFIKDYSNQYQYIATQG
| |  |   | . |.. .. | |.|  .    |  . ||| . .|   ||| ||. ||  |..|     ..|   .||||||.  |. .  |||.||
ihvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvlt...tkrd..sdyinacfvdgyarkncyiaaqg
0039614 (Phosphotyrosine protein) phosphatases II 944-1095 4.3e-37 123.6 In-house 15-162 (297) alignment 
Range on Protein: 944-1095
Range on HMM: 15-162/297.0
PVDKFGEFVANGHAKGNEGFRNQFGMLDSGESDhtVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkDCTNEYINACFIKDYSN-QYQYIATQGPVS
|.. .  ..   .|... .....| .| |   |   ...| | || .||. .|. ||..|. | |..|. |  . |||| ... |.  . ..|||||| .
plsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlp

NTLVDFWQLIWQEKSTIIVMITNIIEEGKvKCQQYWPNSDTkDYGPFSVTLRE
.|. |||...|....|.|||.|. .| |. ||.||||.. .  ||.|.|||..
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 944-1026 7.9e-07 22.7 In-house 7-84 (440) alignment 
Range on Protein: 944-1026
Range on HMM: 7-84/440.0
PVDKFGEFVANGhaKGNEGFRNQFGMLDSGESDHTVTVGLtPSNKLLNRFANIVVYDDNRITLRPMPGHKDctNEYINACFIK
 |  | ..| |   .    | ... .| || |. .   .| |.||. ||. ||..|| .|. |  . |  |  ..|||| .|.
ivadfadyvqnn..rrsrafedewsllpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyin
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 945-1094 4.2e-32 106.5 In-house 7-154 (325) alignment 
Range on Protein: 945-1094
Range on HMM: 7-154/325.0
VDKFGEFVANGHAKGNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDYSNQYQYIATQGPVSNT
| .. |.| . .|. ..|| ..||.| | ..  . .|   | ||  ||| |.| .| .|. |  .  ..|   .|||| ...|. ..  ..|.| | ..|
vvnlvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltat

LVDFWQLI--WQeksTIIVMITNIIEEGKVKCQQYWPNS--DTKDYGPFSVTLR
. |.|.|.  |.   . .|...|....|| .| .|||.   ..| .|.. | ||
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 946-1091 2e-23 77.5 In-house 5-145 (439) alignment 
Range on Protein: 946-1091
Range on HMM: 5-145/439.0
DKFGEFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPS--NKLLNRFANIVVYDDNRITLRPMPGHKDctNEYINACFIKDYSNQYQYIATQGPVSN
|.| | | . . . .| |.. | ...| . |...   |.    ..  ||. ... .|  |.||. .||       |||| .|| | ..  |||||||  .
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph..shyinanyikGyyddklyiatqgpkke

TLVDFWQLIWQEKSTIIVMITNIIEEGKvkcqqYWPNSDTKDYGPFSV
|  |||.|....|.. |||.||..|  |     ||| ..   ||  .|
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiav
0040438 (Phosphotyrosine protein) phosphatases II 947-1095 3.2e-41 137.0 In-house 4-149 (317) alignment 
Range on Protein: 947-1095
Range on HMM: 4-149/317.0
KFGEFVANGHAKGNEGFRNQFGMLDSGESDhTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDctNEYINACFIKDYSNQYQYIATQGPVSNTLV
.. ...   ..... .....| .|.|   | | .|.. | || .||. .|. ||..|. | |..|. |  . |||| ... .. . ..|||||| .||. 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntve

DFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
|||...|....|.|||.|.  | |..||.||||. .|. ||.|.|||..
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtlls
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 948-1092 9.9e-22 71.9 In-house 14-155 (310) alignment 
Range on Protein: 948-1092
Range on HMM: 14-155/310.0
FGEFVANGHAKGNEGFRNQFGMLDSgESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPmpgHKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVD
. .|.      | ||. .|.  ||. . | ..|      .   ||....|. |. |. |.     |   ..|| | ..|    .  .| .|||.  |..|
lenfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklki...dksryedyihanyvktnylrstficsqgplqhtiid

FWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS-DTKDYGPFSVT
||..|.||..  |... .. |||. ||  |||    |. ||   ||
fwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 950-1095 1.7e-43 143.7 In-house 10-154 (288) alignment 
Range on Protein: 950-1095
Range on HMM: 10-154/288.0
EFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPghKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFW
. ||. .|....|| ...  | . |....||.|  . |.  ||. ||. || .|. |. ..  .  ...|||| .|... .. .|||||||. .|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvndfW

QLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDT-KDYGPFSVTLRE
.|....|.. |||.|...|.|| ||..|||..|. | || . |||.|
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlve
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 950-1095 4.7e-39 129.4 In-house 16-162 (298) alignment 
Range on Protein: 950-1095
Range on HMM: 16-162/298.0
EFVANGHAKGNEGFRNQFGMLDSGES---DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCtnEYINACFIKDYSNQYQYIATQGPVSNTLV
...|  ..|.  |. ..|  |.|..|   ... .|. .|.||  ||.|.|. .|  |. |. . . ...  .|||| |.. |...  .||||.|. .|..
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetve

DFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
|||.....|... |||.||. | .|.|...|||.. .. || ..|.|..
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvslls
subfamily_PTPN6_pd Subfamily PTPN6 950-1093 1.6e-36 120.9 In-house 15-160 (306) alignment 
Range on Protein: 950-1093
Range on HMM: 15-160/306.0
EFVANGHAKGNEGFRNQFGMLDSGESDHTV--TVGLTPSNKLLNRFANIVVYDDNRITLRpmpGHKDCTNEYINACFIKD--YSNQYQYIATQGPVSNTL
|.  ... ....|| ..|  |.  |. ...  . |  |.||  ||. ||. .|..|..|.    ..   ..|||| .||.   ... .|||||| ...|.
elekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettv

VDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSD-TKDYGPFSVTL
 |||...|||.|..|||.|. .| || || .|||..  ...||  ||| 
sdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtn
subfamily_PTPN9_pd Subfamily PTPN9 950-1092 9.4e-34 111.8 In-house 5-147 (297) alignment 
Range on Protein: 950-1092
Range on HMM: 5-147/297.0
EFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFW
|.||  ..||..| ....  . . .   |...  ...|   ||..... ||. |..|  .....  . .|||| |.  | ..  .||||||. .|  |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfW

QLIWQEKSTIIVMITNIIEEGKVKCQQYWP--NSDTKDYGPFSVT
...|...  .|||.| ..|.|..||.||||  . .....| .||.
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 950-1084 7.6e-19 62.6 In-house 11-139 (305) alignment 
Range on Protein: 950-1084
Range on HMM: 11-139/305.0
EFVANGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkdctnEYINACFIKDYSNQYQYIATQGPVSNTLVDFW
.|| .   || .|.|..|  .   .  . .       ..  ||. ..   |.||. |..   |     ||| | ..   .|  ..| || |. .|  |||
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfw

QLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDtK
 . .|.|   | |. |..| |  ||..|..  | |
ymclqdkveaifmlcnllekgakkcleyfaskd.k
0047943 (Phosphotyrosine protein) phosphatases II 956-1095 1e-39 132.1 In-house 7-143 (273) alignment 
Range on Protein: 956-1095
Range on HMM: 7-143/273.0
HAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmpghKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQE
...|. ... .| .| |   ..| .|.| | || .||. .|. ||..|. |      .| .. |||| ... |  . ..|||||| .||. |||...|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KSTIIVMITNIIEEGKVKCQQYWPNSD---TKDYGPFSVTLRE
....|||.|...| |..|| ||||..    .. ||.|.|||..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtlls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 956-1093 8.2e-39 128.4 In-house 10-146 (281) alignment 
Range on Protein: 956-1093
Range on HMM: 10-146/281.0
HAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQE
... |.|| ...  | . . |.| |   .. |.| ||. ||| ||  |... |   ... ...|||| |.. |... .|||||||| ..||.|||..|..
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpn..eenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

KSTIIVMITNIIEEGKVKCQQYWPNSD-TKDYGPFSVTL
| ..|||.|. ||.||.|| .|||. . .  || . |. 
kvsaivmvtreieagklkChrYWPddnselkygdvtvks
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 956-1095 2.1e-38 126.8 In-house 4-138 (283) alignment 
Range on Protein: 956-1095
Range on HMM: 4-138/283.0
HAKGNEGFRNQFGMLDSGESDHTVTVglTPSNKLLNRFANIVVYDDNRITLRPMPGhkdctnEYINACFIK---DYSNQYQYIATQGPVSNTLVDFWQLI
....|. ||...  |   . | ....  .  ||  ||. .||..| .|. |.. .       .||||.||    .| .. .||..|.|. .| ||||...
rvnnnklfrevlkrlsvpdldadias..adenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKDYGPFSVTLRE
..|| | |||.|.. |. ..|| ||||.  ..|||.| ||||.
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 956-1084 1.8e-20 68.1 In-house 11-134 (307) alignment 
Range on Protein: 956-1084
Range on HMM: 11-134/307.0
HAKGNEGFRNQFGMLDSGEsDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpMPGhkdCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQE
  || . ....| .|   .  ..|||    .|   ||. .. . | .|| .. ..|    . .|| | ..    .  ..|..|||  ||  .|| .. ||
ldkgvqalvdefrvlakkt.pegvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiqe

KSTIIVMITNIIEEGKVKCQQYWPNSDTK
|   ..|. ..|| .|.||.||||  . .
kvesvimlckvielakikceqywpleegq
subfamily_ptpA1_pd Subfamily ptpA1 956-1081 3.2e-20 67.3 In-house 16-138 (418) alignment 
Range on Protein: 956-1081
Range on HMM: 16-138/418.0
HAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGhKDcTNEYINACFIkDYSNQYQYIATQGPVSNTLVDFWQLIWQE
| |     ...| .|.        . |    |   ||..||.  .  |. |. .   |.  ..|||| .| | .   |.|.||||. ||. |||...|..
hikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd.ke.gsdyinanyi.dgaypkqfictqgplpntiadfwrmvwen

KSTIIVMITNIIEEGKVKCQQYWPNS
.  ||||..   |. ..||..|||. 
rcriivmlsresencrikcdrywpeq
0036941 (Phosphotyrosine protein) phosphatases II 957-1095 4.2e-40 133.3 In-house 9-143 (297) alignment 
Range on Protein: 957-1095
Range on HMM: 9-143/297.0
AKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmpghKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEK
.... ... .|  |..   . . .|.| | |. .||. .|. ||..|. |      .|  . ||||.... |. ....|||||| .||. |||...|...
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

STIIVMITNIIEEGKVKCQQYWPNS--DTKDYGPFSVTLRE
.|.|||.|. .| |..||.||||.   ... ||.|.|||..
vtvIvmltelvelgrekcaqywpleegesltygdftvtlls
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 958-1098 7e-43 141.4 In-house 12-156 (301) alignment 
Range on Protein: 958-1098
Range on HMM: 12-156/301.0
KGNEGFRNQFGMLDSGEsDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKS
| ...| .|.  |..|| |.. ||||. .|| |||| ||.|||||||.|.|.|  . |..||||| .|..||.. ..||.|||. .||||||.|||||| 
khsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TIIVMITNIIEEGKVKCQQYWPNSD--TKDYGPFSVTLRE---HPD
. |||.||  |. | ||.||||||.  ....|||.||| .   .||
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPd
subfamily_PTPN23_pd Subfamily PTPN23 959-1095 1e-30 101.6 In-house 13-148 (288) alignment 
Range on Protein: 959-1095
Range on HMM: 13-148/288.0
GNEGFRNQFGMLDSGESDHTV--TVGLTPSNKLLNRFANIVVYDDNRITLRpmpghkDCTNEYINACFIKDYSNQ-YQYIATQGPVSNTLVDFWQLIWQE
|. .. ..|  |.. .  ..   .. .   .   ||. .|. || ||..||      . ...||||.|.|| | .  ..||||.|  .|| |||......
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

KSTIIVMITNIIEEGKVKCQQYWPNS--DTKDYGPFSVTLRE
|| .|||...  | || |...|||..  .|. .|..||||..
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlks
subfamily_PTPRK_pd Subfamily PTPRK 962-1093 3.2e-33 109.9 In-house 23-146 (314) alignment 
Range on Protein: 962-1093
Range on HMM: 23-146/314.0
GFRNQFGMLDSGesdhtVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGhkDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIV
||....  |  |       .     |.  ||. .|. ||  |..| .. |  |  ..|||| .|  | .  ..|.||||. .|. |||.|...|... ||
gfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MITNIIEEGKVKCQQYWPNsDTKDYGPFSVTL
|.|...|.|.||| .|||. ||. ||.. |.|
mltelvevgrvkClkyWPe.dtevygdikvel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 962-1081 6.4e-21 69.2 In-house 12-130 (281) alignment 
Range on Protein: 962-1081
Range on HMM: 12-130/281.0
GFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRP-MPgHKDCTnEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTII
 |...|  |        .||   | |.  ||..|| . |  |. |.  ||  |. | .|| | .|.    .  || ||||  .|  |||..||||..| |
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmp.nknst.dyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMITNIIEEGKVKCQQYWPNS
||. ...|  . || .|.|  
vmlcqfletnrekcaeyfprn
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 962-1068 4.4e-06 19.5 In-house 27-126 (346) alignment 
Range on Protein: 962-1068
Range on HMM: 27-126/346.0
GFRNQFGMLDSGESDHTVTVglTPSNKLLNRFANIVVYDDNRITLRpMPGHKDCtnEYINACFIKDySNQYQYIATQgPVSNTLVDFWQLIWQEKSTIIV
  |..||.|||   ..|.      .||. || .   .||.||. |   |||.|   .||||. |   ..  . .|.  |.   || .. .|.| .  .||
kireefgfldslvcnktted..feankvrnregcpkiydenrvqln.rpghedv..nyinasvitl.kdvsrrmacv.payvhlvvlyfvifqfehkliv

MITNIIE
     .|
aqlpqme
0046845 (Phosphotyrosine protein) phosphatases II 963-1095 2.1e-39 131.0 In-house 2-141 (284) alignment 
Range on Protein: 963-1095
Range on HMM: 2-141/284.0
FRNQFGMLDSGESDH--TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkDCTNEYINACFIKDY-----SNQYQYIATQGPVSNTLVDFWQLIWQE
.. .| .| |   ..  ...|.| | |. .||. .|..||..|. |....|. . ...|||| ... |      .. ..||||||..||. |||...|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSTIIVMITNIIEEGKVKCQQYWPNSD-TKDYGPFSVTLRE
....|||.|...| |..|| ||||... .. ||.|.|||..
nvrvIVmltelvengrekcaqYwplegevltygdftvtlls
DSPc_SM00195 963-1095 6.3e-38 126.0 In-house 2-134 (263) alignment 
Range on Protein: 963-1095
Range on HMM: 2-134/263.0
FRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkdCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVM
....|  |.. .|....| .  ..||  ||. ||..||..|. | . ...   ...|||| .|| .... .||||||| ..|. |||...|.||..||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ITNIIEEGKVKCQQYWPNS--DTKDYGPFSVTLRE
.|.  |.|| ||..|||..  .....| .||.|.|
lteeeengkekcdrywpeesggketfgkisvklve
PTPc_SM00194 963-1095 6.3e-38 126.0 In-house 2-134 (263) alignment 
Range on Protein: 963-1095
Range on HMM: 2-134/263.0
FRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkdCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVM
....|  |.. .|....| .  ..||  ||. ||..||..|. | . ...   ...|||| .|| .... .||||||| ..|. |||...|.||..||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ITNIIEEGKVKCQQYWPNS--DTKDYGPFSVTLRE
.|.  |.|| ||..|||..  .....| .||.|.|
lteeeengkekcdrywpeesggketfgkisvklve
subfamily_PTPN3_pd Subfamily PTPN3 966-1094 4.1e-32 106.2 In-house 20-147 (280) alignment 
Range on Protein: 966-1094
Range on HMM: 20-147/280.0
QFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmpghkDCTNEYINACFIKDYSN----QYQYIATQGPVSNTLVDFWQLIWQEKSTIIV
|| .|   . . ....   | |   ||. .|. ||. |..|.      . ...|||| ...  ..      .|||||||...|  ||||..|..||..||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MITNIIEEGKVKCQQYWPN-SDTKDYGPFSVTLR
|.|...|.|.||| ||||. .|. .|| |||...
mlttlverGrvkChqyWPetedeleygefsvkce
0045098 (Phosphotyrosine protein) phosphatases II 971-1095 5.4e-35 116.5 In-house 17-127 (278) alignment 
Range on Protein: 971-1095
Range on HMM: 17-127/278.0
DSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITlrpmpghkdctnEYINACFIKDYsnQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEG
 .  .  ..|..| ..|. .||. .|. || .|.             .|||| .|. |  . ..||||||  .|. |||...|....|.|||.|. .| |
lllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KVKCQQYWPNSDTKDYGPFSVTLRE
..|| ||||..... ||.|.||| .
rekcaqywpeggsltygdftvtlls
subfamily_PTPN1_pd Subfamily PTPN1 972-1084 8e-28 92.0 In-house 17-123 (290) alignment 
Range on Protein: 972-1084
Range on HMM: 17-123/290.0
SGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmpghKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGK
   ||.....  .|.|. |||. ..  ||  ||.|      ..  |.|||| ...    . .|| ||||..||   |||..|..||  .||. ...|...
keasdfptreaklpenrnlnryrdvspydhsrikl......eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

VKCQQYWPNSDTK
.||.||||. . .
ikcaqywPqgeee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 972-1085 3.5e-23 76.9 In-house 34-157 (350) alignment 
Range on Protein: 972-1085
Range on HMM: 34-157/350.0
SGESDHTVTVGLTPSNKllNRFANIVVYDDNRITLR--PM----PGHKDCTNEYINACFIKDY------SNQYQYIATQGPVSNTLVDFWQLIWQEKSTI
|   |  .. |.    |  ||. ||. |. .|. |.  .       |   ||.|||| ..|          ...|||||.|. .|. ||...| . | ..
spsnDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkv

IVMITNIIEEGKVKCQQYWPNSDTKD
|...|. .| .  ||..||.. . .|
ilsltsdvelnlekcyrYWqegsydd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 972-1082 2.7e-12 40.7 In-house 35-157 (349) alignment 
Range on Protein: 972-1082
Range on HMM: 35-157/349.0
SGESDHTVTVGLTPSNKllNRFANIVVYDDNRITLRPMP----GHKD-------C-TNEYINACFIK--DYSNQYQYIATQGPVSNTLVDFWQLIWQEKS
|   |  .. |.    |  ||. .|. |.  |. |.  .    . |        .  ..|||| ..|   .| . .||||| |.  |. ||...|  .. 
seiddvilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngv

TIIVMITNIIEEGKVKCQQYWPNSD
 ... ...  |..  ||..|| . .
klvlsLnddkelslekcdiywqels
subfamily_PTPRN_pd Subfamily PTPRN 974-1093 1.8e-26 87.5 In-house 42-161 (297) alignment 
Range on Protein: 974-1093
Range on HMM: 42-161/297.0
ESD-HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYS-NQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGK
|.. .| .|. .. |   || .... ||..|..|.    ..  ...|||| .| |    .  |||||||...|. ||||..|.. ...||..|.. ||| 
eaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv

VKCQQYWPNSDTKDYGPFSVTL
 .|..|||.  .. |. . | |
kqckrywpdeGsevyhiyevhl
0049772 (Phosphotyrosine protein) phosphatases II 975-1076 2.2e-15 52.7 In-house 34-156 (314) alignment 
Range on Protein: 975-1076
Range on HMM: 34-156/314.0
SDHTVTVGLTPSNKLLNRFANIVVYDdNRITLRPMPGhKDctNEYINACFIKDYsnqYQYIATQGPVSNTLVDF----------WQLI--WQEKSTIIVM
...|..|.  . |.  ||. .|. .| ||  |  .|. ..    |||| ... .    ..|||||| ..|.|||          |...  .. .. .|||
peltilvadlflnrdknryldilpad.nrvilpglpv.sg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITNIIEEGkvkcqQ
                     .... . |      
srdevladelsrLdaAlgKtpllildgng.....n
subfamily_PTPN14_pd Subfamily PTPN14 976-1092 2.5e-30 100.5 In-house 38-157 (300) alignment 
Range on Protein: 976-1092
Range on HMM: 38-157/300.0
DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMpghKDCTNEYINACFIKDY--SNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVK
| .....  | |.  ||| ... |.|||. | |    |. ...||||  ||    .....||..|||. .|. ||||..|... ..|||.|...|.|| |
dallstaklpenaeknrfkdvlPyednrvelspt...kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CQQYWPNS----DTKDYGPFSVT
. .|.|..    .| ..| | ||
sfkyfPkleskkktvefgkfkvt
subfamily_PTPN13_pd Subfamily PTPN13 976-1084 1.3e-28 95.1 In-house 26-129 (273) alignment 
Range on Protein: 976-1084
Range on HMM: 26-129/273.0
DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGhkdctneYINACFIKDY--SNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVK
  |..|| . .||  ||. |.. ||. |..|    |       |||| .||     ..|.|||.|||. .|  ||||..|. |...|.|.|.  |.||||
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CQQYWPNSDTK
|..|||.|  |
chrywPesknk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 977-1093 5e-27 89.2 In-house 33-149 (515) alignment 
Range on Protein: 977-1093
Range on HMM: 33-149/515.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQ
.  ||     |   ||. ||. || .|. |  .  . .  ..|.|| .|. . |.  |||.|||   .. |||.|..||. | |.|.|.  |. |.|| .
ypqtvaqeeinfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgk

YWPN--SDTKDYGPFSVTL
|||.  .|.  .| ..| |
yWPdkpgdsvkfGsikvel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 977-1087 2.1e-17 58.0 In-house 23-126 (267) alignment 
Range on Protein: 977-1087
Range on HMM: 23-126/267.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmpghkDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEgkvKCQQ
 |..  ..  |.  ||. . . |||.|. ||      . ..||||| ... |  . ..|.||.|..||  ||...| ..| ..||..|.. ..   . ..
stisqsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirl

YWPNS--DTKDYG
.||    ..| | 
fwPPkmgqakkyq
0040439 (Phosphotyrosine protein) phosphatases II 978-1095 4.4e-33 110.3 In-house 2-117 (249) alignment 
Range on Protein: 978-1095
Range on HMM: 2-117/249.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGhkDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQY
...|.| | || .||. .|. || .|. | ..||     . |||| .|. |  . ..|||||| ..|. |||...|....|.|||.|.  | |..||.||
eysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPNSDTKDYGPFSVTLRE
||..... || |.|||..
wplggsleygdftvtlls
subfamily_PTPN12_pd Subfamily PTPN12 978-1095 3.2e-32 106.6 In-house 31-148 (290) alignment 
Range on Protein: 978-1095
Range on HMM: 31-148/290.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQY
. ..| ...|.  ||. .|. || .|..|. . ...   ..|||| |||  ... .|||.|||...|| |||..||. . .|.||. ...| || ||..|
steagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPNSDTK--DYGPFSVTLRE
||..  .   .|.|.||| |
Wpeegeeelefgefevtlee
subfamily_egg_pd Subfamily egg 978-1084 1.3e-14 48.6 In-house 31-133 (307) alignment 
Range on Protein: 978-1084
Range on HMM: 31-133/307.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHkdCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEgkVKCQQY
..|  ..  |.   |   .   |  |..|.   |    ....| |  .|      ..| .| |. ||  |||....||.   |||.|   |    .|. |
slttaasdnnlekarskrvhckdssrvklelrrGq..ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPNSDTK
||.....
wpkaesd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 980-1093 1.1e-29 98.8 In-house 54-159 (319) alignment 
Range on Protein: 980-1093
Range on HMM: 54-159/319.0
TVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITniieegKVKCQQYWP
|    . ||  ||. ||. .| |.. |... |      .|||| |.. | .. .|||.|||  ||| |||..||. ... ||..|      | || ||||
tfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

NSDTKDYGPFSVTL
.   . .. | | .
lkivikeerfkvkv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 980-1093 1.6e-29 98.3 In-house 18-123 (284) alignment 
Range on Protein: 980-1093
Range on HMM: 18-123/284.0
TVGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITniieegKVKCQQYWP
|    . ||  ||. .|. .| |.. |... |      .|||| ||. | .. .|||||||  ||| |||..||. ... ||..|      | || ||||
tfanldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

NSDTKDYGPFSVTL
.   . .. | | .
lkivikeerfkvkv
0037934 (Phosphotyrosine protein) phosphatases II 980-1094 2e-28 95.0 In-house 3-108 (243) alignment 
Range on Protein: 980-1094
Range on HMM: 3-108/243.0
TVGLTPSNKLLNRFANIVVYDDNRITLrpmpghKDctNEYINACFIKDYSNqyqYIATQGPVSNTLVD----FWQLIWQEKSTIIVMITNIIEEGKVKCQ
...| | |.  ||. .|. ||..|. |      ..  . |||| .|. . .   .|||||| ..|. |    ||...|....|.|||.|. .| |..|| 
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPnsDTKDYGPFSVTLR
||||  ... ||.|.||| 
qywp..gevtygdftvtll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 981-1094 2.4e-33 110.4 In-house 3-113 (250) alignment 
Range on Protein: 981-1094
Range on HMM: 3-113/250.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCtnEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVkCQQYWPN
|.  |.||  ||.|.|. .|  |. | .  | |..  .|||| |.. |...  .||||||...|..|||.....|||. |||.||. |..|. ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SDTKDYGPFSVTLR
  .. ||   |.| 
ekaekyGdvtvsll
0042113 (Phosphotyrosine protein) phosphatases II 981-1095 1.8e-31 104.8 In-house 3-115 (245) alignment 
Range on Protein: 981-1095
Range on HMM: 3-115/245.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMPGHKDCTneYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN
|.| | || .||. .|. ||..|. | |..|. |..  ||||.... |    ..|||||| ..|. |||...|....|.|||.|.  | |.|||.||||.
vallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

SDTKDYGPFSVTLRE
.... || |.|||..
gesltygdftvtlls
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 982-1083 8e-28 92.2 In-house 15-115 (270) alignment 
Range on Protein: 982-1083
Range on HMM: 15-115/270.0
GLTPSNKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDY-SNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN
  .  .| |||.|.|.     |..| ..  ..| . .|||| ... . ... .|||..||. .|| .||..||.||.| |||.|.. |.|. ||..|||.
peaargkklnRyadiLPsPatRvrleel..eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

SDT
.  
epk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 982-1086 1.2e-11 38.7 In-house 91-186 (244) alignment 
Range on Protein: 982-1086
Range on HMM: 91-186/244.0
GLTPSNKLLNRFANIVVYDDNRITLRpmpgHKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEgkvkcQQYWPNS
 . |.|   || .  . .| ||. |     .    | |||| |.       .|| || |...| .|||... . .  ..|..  . ||     ..|||.|
afnpnnswknregaglpfdfnrvpls....kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds

DTKDY
.  ..
eplew
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 985-1084 1.9e-24 81.0 In-house 31-128 (297) alignment 
Range on Protein: 985-1084
Range on HMM: 31-128/297.0
PSNKLLNRFANIVVYDDNRITLRPMPGHKDctneYINACFI--KDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSD
.|    ||. .|. .||.|. |.  .  .|    |||| ..   |  ....|| .|||.|.|. |||.|....   .|||.... |.|. ||  |||...
nsslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

TK
 .
qe
subfamily_CG42327_pd Subfamily CG42327 985-1095 2e-19 64.4 In-house 26-139 (319) alignment 
Range on Protein: 985-1095
Range on HMM: 26-139/319.0
PSNKLLNRFANIVVYDDNRITLRPMPgHKDcTNEYINACFIKDYSN-QYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDT
.. |  .|..|.|   . |..|. ..  .|  .||..| ... | . . .|||.| .  ..  |||...|. .| .|| .|.. | |  .| .|.| ..|
vtskdksrvinvvPlPetrvvlqrig.ddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

KD----YGPFSVTLRE
 |    || . |||..
ldntslyGdilvtlkg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 986-1094 2.1e-30 100.7 In-house 2-108 (237) alignment 
Range on Protein: 986-1094
Range on HMM: 2-108/237.0
SNKLLNRFANIVVYDDNRITLRPMPGHkdctNEYINACFIKDYSN-QYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDT-
 ||. ||..|||.|| .|. |.   .      .||||...|..     .|||.|||. ..  ||||..|||| ..|||.| .||  ..|| .|||..|  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

KDYGPFSVTLR
. || ..|.|.
aaygvltvslk
subfamily_CG7180_pd Subfamily CG7180 986-1093 1.6e-24 81.1 In-house 41-145 (296) alignment 
Range on Protein: 986-1093
Range on HMM: 41-145/296.0
SNKLLNRFANIVVYDDNRITLRPMPGHKDCTneYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKvKCQQYWPNSDTKD
 |.  ||  ..| || ||. |. . |...    |||| ..  .  . .|| |..|. .|. .||.|...|..  .|..|.  .  | ....||||   ..
enreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGPFSVTL
||.. | .
ygeifvei
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 986-1095 3.3e-16 54.1 In-house 34-140 (285) alignment 
Range on Protein: 986-1095
Range on HMM: 34-140/285.0
SNKLLNRFANIVVYDDNRITLrpmpghKDCTNEYINACFIKDY-SNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS--D
.|  |||.|.. . .. |. |      |.   .|| | ...    .|  ||.||||. .|| |||..|.||| . ..|.  ..| |  ||  |.|.   .
anpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TKDYGPFSVTLRE
   .| . .|| |
vvkfgkyeitlte
Y_phosphatase Protein-tyrosine phosphatase 987-1094 4.6e-35 116.5 Pfam-A 1-106 (235) alignment 
Range on Protein: 987-1094
Range on HMM: 1-106/235.0
NKLLNRFANIVVYDDNRITLRPMPGHKDctneYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWP--NSDTK
||  ||. .|..||..|. |.  .|..|    |||| ..| |... ..||||||...|. |||...||||...|||.|.  |.|..||.||||  .....
nkkknRykdilpydktrvklkgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

DYGPFSVTLR
 || ..|.|.
tygdikvelk
Y_phosphatase Protein-tyrosine phosphatase 987-1094 4.6e-35 116.5 In-house 1-106 (235) alignment 
Range on Protein: 987-1094
Range on HMM: 1-106/235.0
NKLLNRFANIVVYDDNRITLRPMPGHKDctneYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWP--NSDTK
||  ||. .|..||..|. |.  .|..|    |||| ..| |... ..||||||...|. |||...||||...|||.|.  |.|..||.||||  .....
nkkknRykdilpydktrvklkgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

DYGPFSVTLR
 || ..|.|.
tygdikvelk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 987-1095 1.2e-28 94.9 In-house 7-113 (239) alignment 
Range on Protein: 987-1095
Range on HMM: 7-113/239.0
NKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDYSNQ-YQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKd
||  ||.|||| || .|. |  .   .|  ..|||| ...||      |||||| |. .  |||...|||.  .|||.| .||  | ||.||||.| .| 
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLRE
|  . ||||.
ycnlrvtlrk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 987-1095 1.3e-28 94.7 In-house 8-114 (239) alignment 
Range on Protein: 987-1095
Range on HMM: 8-114/239.0
NKLLNRFANIVVYDDNRITLRPMpgHKDCTNEYINACFIKDYSNQ-YQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTKd
||  ||.|||| || .|. |  .   .|  ..|||| ...||      |||||| |. .  |||...|||.  .|||.| .||  | ||.||||.| .| 
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLRE
|  . ||||.
ycnlrvtlrk
0041856 (Phosphotyrosine protein) phosphatases II 987-1083 8.8e-16 53.5 In-house 1-76 (182) alignment 
Range on Protein: 987-1083
Range on HMM: 1-76/182.0
NKLLNRFANIVVYDDNRitlrpmpghkdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITniieegkvkCQQYWPNSDT
|. .||. .|. || .|             . |||| ..  .  . ..||||||  .|. ||........ |.||..|         . .|||.  .
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpelle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 987-1081 1.5e-11 38.9 In-house 43-131 (288) alignment 
Range on Protein: 987-1081
Range on HMM: 43-131/288.0
NKLLNRFANIVVYDDNRITLRpmpghkDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS
|   .|. |.   |  |. |       | .. ||.|  .    .. . | .| |.  |.  .|... ..    |||.....| || | ..|.|  
nptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 987-1074 7.7e-08 26.2 In-house 34-118 (332) alignment 
Range on Protein: 987-1074
Range on HMM: 34-118/332.0
NKLLNRFANIVVYDDNRITLRPMPGHKDctneYINACFIKDYSNQYQYIATQGPVSN-TLVDFWQLIWQEKSTIIVMITNIIEEGKVKC
|  .||   . ..| .|. | |  |. |    . || ..  ||..  || .| |. . |   ||... . | ..|... .| |. | |.
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 987-1075 1e-06 22.6 In-house 47-126 (303) alignment 
Range on Protein: 987-1075
Range on HMM: 47-126/303.0
NKLLNRFANIVVYDDNRITLrpmpghkdCTNEYINACFIkDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQ
|   |||..... |  .. |        .   || | .. .   . . | || |.| |  ||||.| ..|   ....    |  |.  .
nmdknrfvdvicldhskvkl........sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 988-1091 5.3e-28 92.9 In-house 29-136 (274) alignment 
Range on Protein: 988-1091
Range on HMM: 29-136/274.0
KLLNRFANIVVYDDNRITLRPMPGHkDCTNEYINACFIKDYSNQY-QYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTK--
.  ||. .|.  .  |..|..  .. |   .|||| .|| |...   |.|||||..||. |||..|.||....|||.|.. |. . ||..|.|..     
qtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--DYGPFSV
   || ...
serygdvei
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 988-1078 2.6e-13 44.4 In-house 44-128 (312) alignment 
Range on Protein: 988-1078
Range on HMM: 44-128/312.0
KLLNRFANIVVYDDNRITLRpmpGHkdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYW
| |||. || ..|  |.||    |     | || | |.|  ..  ....||||. || . ||||     || |.... ..|.|  || .| 
kdlnrypniqcwdrgrftla...gd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 990-1083 2e-25 84.2 In-house 41-131 (287) alignment 
Range on Protein: 990-1083
Range on HMM: 41-131/287.0
LNRFANIVVYDDNRITLRPMPGHkdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDT
 ||.|... .||.|. |   . .     .|||| ..  | .. ..||.|||.. |. |||.......|. ....|  .||.. || .|||. . 
knryadvlPiddtrvllsaegel...GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 990-1082 7.1e-15 49.4 In-house 58-146 (305) alignment 
Range on Protein: 990-1082
Range on HMM: 58-146/305.0
LNRFANIVVYDDNRITLRPMPghkdcTNEYINACFIK-DYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSD
 ||.... . | . . |   .       .|| | ..      . ..|..|||. .|. .|| .. |.|   |||. . .| ||.|| |||| . 
knryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 991-1084 1.5e-17 58.1 In-house 60-146 (290) alignment 
Range on Protein: 991-1084
Range on HMM: 60-146/290.0
NRFANIVVYDDNRITLRpmpghKDCTNEYINACFIKDYSNqyQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTK
||. ..|  |  |. |.          .|. | ..|       .| |||.. .| .|.|... ||| . |||. ..||.|| ||.||.|. . .
nrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 991-1069 1.2e-09 32.1 In-house 41-122 (347) alignment 
Range on Protein: 991-1069
Range on HMM: 41-122/347.0
NRFANIVVYDDNRITLRPMP---GHKDCTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEE
||  .  . |. |. | |     .. | .. ||||  ||    . .|| || |. .|. |||...   | | .| | . |..
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_eak_pd Subfamily eak 993-1095 2.2e-10 34.5 In-house 57-158 (332) alignment 
Range on Protein: 993-1095
Range on HMM: 57-158/332.0
FANIVVYDDNRITLRPMPGHkdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSD--TKDYGPFS
  .|| || . . | .        . ||||  ..      .|| |  .  . .  |||.. ..||  ||.. . .|..  | ..|.|.      ..| . 
vvkivpydrylvrltssqln...rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLRE
|. .|
verke
0044763 (Phosphotyrosine protein) phosphatases II 999-1083 1.6e-09 33.1 In-house 2-75 (178) alignment 
Range on Protein: 999-1083
Range on HMM: 2-75/178.0
YDDNRITLRPMPGHKDctNEYINACFIKDYsnqyQYIATQGPvsntlVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDT
.|..|  | ...|.     .||||..| ..     |.....|     .|...|..... | ||..|. .| |..|| .||| .  
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1000-1081 6.2e-07 23.8 In-house 31-120 (290) alignment 
Range on Protein: 1000-1081
Range on HMM: 31-120/290.0
DDNRITLRPMpgHKDCTNEYINACFIKdYSNQYQYIATQGPVSN-------TLVDFWQLIWQEKSTIIVMITNIIEEGKV----KCQQYWPNS
 ..|. |.     |  ...|| | ... ..|  . |.|| |  .       |. .|| .. |||.. .||. .  |. .      |..| |.|
eatrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1001-1106 1.6e-09 32.1 In-house 7-101 (130) alignment 
Range on Protein: 1001-1106
Range on HMM: 7-101/130.0
DNRITlrpmpghkdcTNEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEgkvkcQQYWPNSDTKDYGP----FSVTLREH
 .|.            |.|||| |.    .  .|. || |...| .|||... .    ..|..  . ||     ..|||.|.  ..       ..| |. 
vsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrde

PDYINAVFIN
 ..|.| ...
fknikasnle
0046846 (Phosphotyrosine protein) phosphatases II 1016-1080 1.6e-12 43.0 In-house 11-71 (176) alignment 
Range on Protein: 1016-1080
Range on HMM: 11-71/176.0
TNEYINACFIKDYsnqyQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN
   |||| .|  .     .||||||. .|| ||........ |..|..|. .| |..|| .||| 
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe
0051429 (Phosphotyrosine protein) phosphatases II 1017-1082 7.7e-14 47.5 In-house 4-71 (272) alignment 
Range on Protein: 1017-1082
Range on HMM: 4-71/272.0
NEYINACFIKDYsnqYQ------YIATQGPVSNTLVDFWQLiWQEKSTIIVMITNIIEEGKVKCQQYWPNSD
. |||| ... |   ..      .....||  .|  |||.| .... . ||....  | |..|| .|||. .
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgir
0036282 (Phosphotyrosine protein) phosphatases II 1017-1080 1e-11 40.3 In-house 2-60 (174) alignment 
Range on Protein: 1017-1080
Range on HMM: 2-60/174.0
NEYINACFIKDYSNQYQYIATQGPVSntlvdFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN
. |||| ... .     .||.||| .     ||........|..|| .. .| |..|| .||| 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe
0043147 (Phosphotyrosine protein) phosphatases II 1017-1080 1.3e-11 40.0 In-house 5-73 (172) alignment 
Range on Protein: 1017-1080
Range on HMM: 5-73/172.0
NEYINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNI-----IEEGKVKCQQYWPN
. |||| ... |    ..|||||| .||| |||....... |.||..|.       .|  .   .|.| 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpw
0051082 (Phosphotyrosine protein) phosphatases II 1017-1082 2e-08 29.5 In-house 3-57 (151) alignment 
Range on Protein: 1017-1082
Range on HMM: 3-57/151.0
NEYINACFIKDYsnqyqYIATQGPVSntlvDFWQLIWQEKSTIIVMITNIIEEGkvKCQQYWPNSD
. |||. .. ..     .....|| .    ||..|..... . ||....  | |  .| .|.|. .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1019-1084 4.7e-12 40.3 In-house 77-142 (301) alignment 
Range on Protein: 1019-1084
Range on HMM: 77-142/301.0
YINACFIKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNSDTK
 | | .|.   .  ..||||||..||  ||| .. | .   |||... .|. . ||..| | . ..
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise
0049260 (Phosphotyrosine protein) phosphatases II 1025-1078 2.8e-12 42.1 In-house 2-55 (152) alignment 
Range on Protein: 1025-1078
Range on HMM: 2-55/152.0
IKDYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYW
|. | .....|||||| .||| |||..... . |.|||.|.  | ||.|| ||.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1027-1093 3.1e-09 30.7 In-house 231-295 (440) alignment 
Range on Protein: 1027-1093
Range on HMM: 231-295/440.0
DYSNQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEgkvKCQQYWP-NSDTKDYGPFSVTL
 ||..  .|||| |.  |..|||.|. . . . |.|. .. .     |  ||| |. .  .|||.|  
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvgh
subfamily_hpo-7_pd Subfamily hpo-7 1028-1081 1.8e-06 22.0 In-house 36-83 (263) alignment 
Range on Protein: 1028-1081
Range on HMM: 36-83/263.0
YSNQYQYiatqgpVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS
  | |        . .|.  |.| | | |.. .||...  |||..||..|.|  
rknlysl......lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1030-1101 3.9e-11 37.5 In-house 3-79 (199) alignment 
Range on Protein: 1030-1101
Range on HMM: 3-79/199.0
NQYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN--SDTKDYGPFSVTLR---EHPDYIN
 | .||||| |. .|. ||||..|.  |  |||. .   . ..    |||   | |  || .||| .    .|||  
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdyti
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1031-1102 4.8e-11 37.2 In-house 3-79 (198) alignment 
Range on Protein: 1031-1102
Range on HMM: 3-79/198.0
QYQYIATQGPVSNTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPN--SDTKDYGPFSVTLR---EHPDYINA
| .||||| |. .|| ||||..|.  |  |||. .   . ..    |||   | |  || .||| .    .|||  .
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytit
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1036-1081 3.4e-07 24.6 In-house 39-77 (255) alignment 
Range on Protein: 1036-1081
Range on HMM: 39-77/255.0
AtqgpvsnTLVDFWQLIWQEKSTIIVMITNIIEEGKVKCQQYWPNS
        |.  |.| | | |.. .||...  |||..||..|.|  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfple
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1078-1308 1.6e-15 51.6 In-house 49-282 (312) alignment 
Range on Protein: 1078-1308
Range on HMM: 49-282/312.0
WPNSDTKDYGPFSVTLREHpDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR----KLGEYNIS-LLN
.|| .  | | |...  |   || | |..     . |.....|. ||. .||..      |.|..||   ..  | | .| |.     .| .. .     
ypniqcwdrgrftlagden.fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteyc

EEIHNAGYIERKIEV----TNDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVIHCSDTVGRSGVFCAAATTI---NKCKTE
 ||   |    ||         . .|.. ....|| . |   |     .| | ..  .     |. .  .. |||  |||.| ..   . |    . . .
teieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkq

GVIDVFQVLKSQRIQkpgSVQTVQQYQGIFQIVLTYLDSFETY
 | |.| .|. .| .   ||... ||   ...|| .| |   |
nvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskgly
0041856 (Phosphotyrosine protein) phosphatases II 1085-1301 8.5e-29 95.8 In-house 9-170 (182) alignment 
Range on Protein: 1085-1301
Range on HMM: 9-170/182.0
DYGPFSVTLreHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenknnqevCYQYWSNRKlgeynisllneeihnagyierk
|. |.  ..  ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|| ..                       
dilpydhsr..dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......................

ievtndnkagdKQQVKQYQITNWDSTGKLTnPQTILLVIEEMYRtqrkrGNTSIVIHCSDTVGRSGVFCAAATTINKckteGvIDVFQVLKSQRIQKPGS
           .... ||. ..|.  |  . ....|  |||...      .  ...|||  |||.|...||   . .    | .......|  | ..||.
...........erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgm

VQTVQQYQGIFQIVLTY
|.| .||. . ...| .
vitpnqyfflqlallel
0050432 (Phosphotyrosine protein) phosphatases II 1091-1309 2.3e-59 196.6 In-house 85-306 (308) alignment 
Range on Protein: 1091-1309
Range on HMM: 85-306/308.0
VTLREHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYW------SNRKLGEYNISLLNEEIhNAGYIE
| | |. ||||| ...||  | ...||.. .|. ||  .||.|. . ||. ||||...  |..| |.|||      . .. | . . ||.||. ...|. 
VkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytv

RKIEVTNDNKAgDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQrkrGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
|..|.|| ..  .  .|.... |||   |  ..|. .|  .|.. ...   ..  ||.|||. |||.|.|.|. . ..  ..|| .|||...|  | |.|
rtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp

GSVQTVQQYQGIFQIVLTYLDSFETYS
|.|||..||. .....| || ...|. 
gmvqtpeqylflyralleylklkltkl
subfamily_PTPN3_pd Subfamily PTPN3 1091-1299 2.6e-33 110.1 In-house 58-272 (280) alignment 
Range on Protein: 1091-1299
Range on HMM: 58-272/280.0
VTLREHP-DYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN----RKLGEYNISLLNEeIHNAGYI
|.|.| . ||||| ..|    . .  . .|..  |. .|| .||.|. ..... |||| .   . .  |.||| .     ..||... . .|  ..  |.
vklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkceke.detksyv

ERKIEVTNDNKaGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMyRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQK
 |.. ... ..  ..... | | ..|   |  .... .| ..|.. |..|.  .. .|.|||  .||.||. .  |.. .  ..  . . ....  | |.
lrelvlkdket.keerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqr

PGSVQTVQQYQGIFQIVL
   |||..||. . . .|
amlvqtasqykfvCeail
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1091-1300 2.8e-32 106.8 In-house 50-257 (267) alignment 
Range on Protein: 1091-1300
Range on HMM: 50-257/267.0
VTLRE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQY--WSNRKLGEYNISLLNEEIHNaGYIERKIEV
| ||.   .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| .  ..|    .       .|  .  .    |.  |  |    .|.
vilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeen.dyqiitlel

TNDNKAGdkQQVKQYQITNWDSTGKltNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
   |..   ..|  |   .|.   .  |   .  ..  . . | . ||  .|..||| ||||| |  . . ... ||||| |.|. |.  | |..| |.|
kfknesa..hnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt

VQQYQGIFQIVLT
 ..|  | ...  
keryiyihellae
subfamily_PTPN13_pd Subfamily PTPN13 1091-1304 1.1e-31 105.1 In-house 54-271 (273) alignment 
Range on Protein: 1091-1304
Range on HMM: 54-271/273.0
VTLREHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK---LGEYN-ISLLNEEI-HNAGYIER
|.| ..  |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .|  ...  | .|| ..|   |  .| . . .... .  |.  |
vklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvr

KIEVtNDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkrGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPG
...| .|...|. ..| . . ..|   |  .... .| .. |. | |.   .. ||.|||  .||||.. .  . ..  . .  .|| ..... | |. |
alav.kdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqg

SVQTVQQYQGIFQIVLTYLDS
 ||| .||  .....|. | |
vvqtkdqyifvykailevlks
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1091-1302 6.2e-16 53.2 In-house 52-270 (285) alignment 
Range on Protein: 1091-1302
Range on HMM: 52-270/285.0
VTLREH-PDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLN-EEIHNAGYIE
| |..|  ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   .   | |  |. ..     |.|.|.|.| . .|   || | 
vvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtil

RKIEVTNDNKAGDKQ-QVKQYQITNWDStgKLtNPQTILLVIeEMYRTQRK--RGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRI
  . |.| . |  .   ... |.  |    .|  |.    .| |.|.  .|    .. |..|||  |||.  |     .  .   .  |.......  | 
naltvintedasseplymnhvqvpwwpd..ql.apedarpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremra

QKPGSVQTVQQYQGIFQIVLTYL
 .  .||.  |.  .. ... |.
mrfqavqshmqflflyvvlmeyf
subfamily_Ptp69D_pd Subfamily Ptp69D 1092-1305 1e-48 161.1 In-house 71-289 (307) alignment 
Range on Protein: 1092-1305
Range on HMM: 71-289/307.0
TLREHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS---NRKLGEYNISLLNEEIHNaGYIERKIEVT
. .|. ||||| ||.|||||| ||.|  |. .|. .||.|| . .|| |||| ...  |.. | .||.   . . |. .. | .|| |.  ||.|...|.
ngkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhs.dyiiReldvs

NDNKAG----DKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGS
. .. .    |...| ||. |.|. .     ....| .||...  ...  .. ||.|||  |||||.| | .  ....|.|  .|.|.. |  | |..  
kkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnll

VQTVQQYQGIFQIVLTYLDSF
||  .||. ... .| | .  
vqsleqYvflyralldyssyg
0044763 (Phosphotyrosine protein) phosphatases II 1092-1298 4.5e-19 64.2 In-house 13-167 (178) alignment 
Range on Protein: 1092-1298
Range on HMM: 13-167/178.0
TLREHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLgeynisllneeihnagyierkievtndn
   |  |||||..| ..     ....  |.     ...... . ..|.||.|..|  .... |..||  .                              
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

kagdkqqvKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVIHCSDTVGRSGVFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVQQY
         ||. ....  |  . .. .| ..| . . .  . .  ...|||  |||||...||   .      |. .......  | ..|  |..  |.
........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgql

QGIFQIV
. . .. 
rqLyefe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1092-1214 2.2e-09 31.7 In-house 8-128 (130) alignment 
Range on Protein: 1092-1214
Range on HMM: 8-128/130.0
TLREHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNqevcyQYWSNRK-LG--EYNISLLNEEIHNAGYIERKIEVT
.  .  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   ....     .|| . . |   | .| .   . ..  .|. .    
srlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnlei

NDNKAGDKQQVKQYQITNWDSTGKLT
...    .| .  .||.|| | |   
esdlneshqaltmfqisnwpsdgttp
subfamily_eak_pd Subfamily eak 1092-1210 7.4e-06 19.6 In-house 73-192 (332) alignment 
Range on Protein: 1092-1210
Range on HMM: 73-192/332.0
TLREHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK-----LGEYNISLLNEeIHNAGYIERKIE
. ...  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. ... |   .|. ..       | ...   .  .... .  |..|
sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.vkrniletrlle

VTNDNKAgdkQQVKQYQITNWDST
..  |..    .|. |..  |  |
lskGnet...hrvlhykvfGwtet
0046846 (Phosphotyrosine protein) phosphatases II 1093-1303 1.6e-26 88.6 In-house 8-174 (176) alignment 
Range on Protein: 1093-1303
Range on HMM: 8-174/176.0
LREHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNrkLGEYNIsllneeihnagyierkievtndnk
|....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|..|   ..  |..||.   | ...|                        
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

agdkqqvkQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKrGnTSIVIHCSDTVGRSGVFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTVQQY
        ||. ..|.  |  .  . .| ..|.... ... |   ...|||  .||.|...||      ...|  ..|...|.  | |.| |.||| .||
........qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

QGIFQIVLTYLD
. . . .| .|.
rflyefellllk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1093-1302 1.7e-21 71.5 In-house 62-271 (288) alignment 
Range on Protein: 1093-1302
Range on HMM: 62-271/288.0
LREHPD-YINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLLNEEI-HNAGYIERKIEVT--
| . || ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.     .|   .|.  ..  .  |  |   . ..   |.. ..|.  
lsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsll

NDNKAGDKQQ-VKQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. .| |.... ||.  . .||  |   | .. | ..| .     |  .  ||.|.|  |||.| .      ..  . .  . . ..|.. | ..  ..||
riskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqt

VQQYQGIFQIVLTYL
 .||  ....|| .|
emqylyvhrcvleel
subfamily_PTPN1_pd Subfamily PTPN1 1094-1297 5e-30 99.2 In-house 53-266 (290) alignment 
Range on Protein: 1094-1297
Range on HMM: 53-266/290.0
REHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS--NR----KLG--EYNISLLNEEIHNAgYIERKI
|.. ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .   ..|  |.|||   ..    .|   .... |..||...  |. |..
radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksy.ytvrll

EVTNdNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQR-KRGNTSIVIHCSDTVGRSGVFCAAATTIN---KCKTEGVIDVFQVLKSQRIQK
|..|  |. . ... ..  | |   |    |.. |  . .. ..   ..     |||||  .|||| || . | .    | .    .|. .||   | ..
elen.lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyr

PGSVQTVQQYQGIFQI
 | .|| .| .  .. 
lGliqtadqlrfsyla
subfamily_ptpA1_pd Subfamily ptpA1 1094-1261 8.8e-17 55.9 In-house 72-255 (418) alignment 
Range on Protein: 1094-1261
Range on HMM: 72-255/418.0
REHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEY-NISLLNEEIHNAgYIERKIEVTNDNK
.|  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .|..| .  | .|| ..  ||  .|    .|.  . |    .|| .| .
kegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgt.ysvelveviqdpe

------------AGDKQQVKQYQITNWDSTG--KLTNPQTILLviEEMYRTQ-----RKRGNTSIVIHCSDTVGRSGVFCAAATTINK
             |. ... |||   |        |.|   ||    .   |         |  |..|||  |||.| ||.|   ..|
reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqll..hsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1095-1311 2.9e-124 408.7 In-house 69-287 (287) alignment 
Range on Protein: 1095-1311
Range on HMM: 69-287/287.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK---LGEYNISLLNEEiHNAGYIERKIEVTNDN
|||||||||||.||||||||||||||||||||||||.|||||||||||||||. |..|||||||.. |   ||||||.||||| .||||||||.||.|.|
ehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknkn

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
|||||||||||||||||||||.|.||||||||||||.|||||||||||.|||||||||..|||||||||||||||||||||||||||||||||||||.||
kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqy

QGIFQIVLTYLDSFETYSNF
..|..|||.|||||||||.|
kfindivleyldsfetysdf
subfamily_PTPRD_pd Subfamily PTPRD 1095-1308 1.2e-58 194.1 In-house 74-287 (564) alignment 
Range on Protein: 1095-1308
Range on HMM: 74-287/564.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR---KLGEYNISLLNEEiHNAGYIERKIEVtNDN
|  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . . .... | .|| ..   . ||. ..| .|| . | |. |.... ...
egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeee.eladyeirtfkl.kkk

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
|  ....|.|.. |.| ..|  ......| .|... ... ....  ||.|||  |||.|.|..    ... |.|...|..|..|  | |..  ||| .||
kssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQY

QGIFQIVLTYLDSFETY
. |....| .|....| 
iFiheailealacgnte
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1095-1308 1.8e-58 193.1 In-house 82-296 (298) alignment 
Range on Protein: 1095-1308
Range on HMM: 82-296/298.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN---RKLGEYNISLLNEEiHNAGYIERKIEVTNDN
|. |||||.|...||...|||... |. .|  .||.|. ......|||| . .  ..  . .|| .   .. || ..|||..| . | .| ||..|.. .
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllske.efadlivrklkvskkk

KAgDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
.. ....|.| . |.| . |  .| ...| ..... ..|.. ||......||. ||||| |.|  . ... |.| |.|||||.|  |...||.||| .||
ee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

QGIFQIVLTYLDSFETY
  |...|| .||||...
vfiyeavlealdsfnde
0046845 (Phosphotyrosine protein) phosphatases II 1095-1310 8.3e-58 191.4 In-house 55-282 (284) alignment 
Range on Protein: 1095-1310
Range on HMM: 55-282/284.0
EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR----KLGEYNISLLNEEIhNAGYIERKI
|. ||||| ...||     . ||.||..  |. ||  .||.|. . ||. ||||...  |..| |.|||..     ..|.. . ||.||. . .|. |..
edsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtl

EVTNDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-RGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEG---VIDVFQVLKSQRIQK
|.|| .  |   .|.....|.|   |  ..|. .|  .... . ...  |.  ||.|||. |||.|.|.|. . ..  ..||   ..||....|  | |.
eltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR

PGSVQTVQQYQGIFQIVLTYLDSFETYSN
||.|||..||. .....| || .. |. .
pgmvqtleqyrfvyealleylklkltlle
0036941 (Phosphotyrosine protein) phosphatases II 1095-1308 3.1e-56 186.2 In-house 61-283 (297) alignment 
Range on Protein: 1095-1308
Range on HMM: 61-283/297.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEIH-NAGYIERKIEVT
|. ||||| ...||. |..||... |. ||  .||.|. . ||| ||||...  .. | |.|||..      . |.. . ||..|.. ...|. |..|||
egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevt

NDnKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVIHCSDTVGRSGVFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGS
.  . |.. .|.....|.|.  |  ..|...|  ||.. . ...  ... ...|||. |||||.|.|| . ..  .   .|| .|.....|. | |.||.
dt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpga

VQTVQQYQGIFQIVLTYLDSFETY
|||..||. . ...| .| ...|.
vqtleqyrflyeallellkkkltk
Y_phosphatase Protein-tyrosine phosphatase 1095-1299 1.7e-54 180.1 Pfam-A 25-234 (235) alignment 
Range on Protein: 1095-1299
Range on HMM: 25-234/235.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS-----NRKLGEYNISLL-NEEIHNAGYIERKIEVT
.. ||||| ...||||||.||... |. .|   ||.|. ...|..||||........| | |||.       . |.... |  .|. ....|. ||.|..
gpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelk

NDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
....  .|..|||...|||   |  ..|. .| .|... ... .  ....|.|||. |||.|.|.|. . ......|. .||.|..|. | |.||.||..
kkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

QQYQGIFQIVL
.||. . ...|
eqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1095-1299 1.7e-54 180.1 In-house 25-234 (235) alignment 
Range on Protein: 1095-1299
Range on HMM: 25-234/235.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS-----NRKLGEYNISLL-NEEIHNAGYIERKIEVT
.. ||||| ...||||||.||... |. .|   ||.|. ...|..||||........| | |||.       . |.... |  .|. ....|. ||.|..
gpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelk

NDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
....  .|..|||...|||   |  ..|. .| .|... ... .  ....|.|||. |||.|.|.|. . ......|. .||.|..|. | |.||.||..
kkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

QQYQGIFQIVL
.||. . ...|
eqYiflykail
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1095-1310 2.2e-54 179.3 In-house 35-250 (250) alignment 
Range on Protein: 1095-1310
Range on HMM: 35-250/250.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEvCYQYWS---NRKLGEYNISLLNEEIHnAGYIERKIEVTNDN
.. |||||.|..||.|.||||.. .|. .|  .||.|. ......|||| . . .... . |||     .| |.  .|||..|.. | |. ||. ... .
kesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeef.adytkrklklskak

KAgDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
|| |...|.|.. ..|   |   . ...| ..... ..|.. ||. ....||  ||||| |.|  . ... |.| |.|||.|.|  |...|..|.. .||
ka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqy

QGIFQIVLTYLDSFETYSN
  ...|.| .|||.| |..
vfvyeiilkaldsvedyar
0045450 (Phosphotyrosine protein) phosphatases II 1095-1302 1.8e-53 177.6 In-house 82-304 (307) alignment 
Range on Protein: 1095-1302
Range on HMM: 82-304/307.0
EHPDYINAVFI--------NGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR----KLGEYNISLLNEEIhNAGYIE
|. ||||| ..        .||. |..||.. .|. .|  .||.|. . .||.||||...  ...| |.|||..       |.. . ||.||.  .||. 
edsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytv

RKIEVTNDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGV---IDVFQVLKSQR
|..|||. .. |   .|.... |.|  .|  ......|  |||. . ...  ... ...|||. |||.|.|.|| . .   ..||.   .|.....|  |
rtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllr

IQKPGSVQTVQQYQGIFQIVLTYL
 |.||.||. .||. . ...| .|
eqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1095-1300 1.2e-50 167.0 In-house 55-264 (283) alignment 
Range on Protein: 1095-1300
Range on HMM: 55-264/283.0
EHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR---KLGEYNISLLNEEIHNaGYIERKIEVT
| .||||||||     ||..| .||| ||. .| ..||||. |...|||||| .   .... | ||| .|   . ||. ..| .|  .|  .| ... . 
esrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsn.sfiikelllr

NDNKAGDKQQVKQYQITNWDSTGKLTNPQTiLLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... | ..  .  ||. .| . |. .   . |. .. .   |..  .. ||.||| ..||..||.||...... .|| |.|||.|.|  | |... ||| 
vnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl

QQYQGIFQIVLT
.||. . ..|| 
dqyklvhelvle
subfamily_PTPRA_pd Subfamily PTPRA 1095-1301 2.1e-48 159.9 In-house 84-294 (330) alignment 
Range on Protein: 1095-1301
Range on HMM: 84-294/330.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKL---GEYNISLLNEEIHnAGYIERKIEVTNDN
|. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .. ..| |.||| .  |   |. .... .|..    |  ||. |.. .
eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvl.vdytvrkflvqqlp

K---AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNtSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.     ....|.|.  | |   |  ..|. .| ..... ..... .. .||.|||  |||.| |..  . ... |.|...|||...|. | |.|  ||| 
datrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd

QQYQGIFQIVLTY
.||. |....| |
eqyefiykvlley
subfamily_PTPN12_pd Subfamily PTPN12 1095-1302 6.3e-45 148.3 In-house 66-277 (290) alignment 
Range on Protein: 1095-1302
Range on HMM: 66-277/290.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEIHNAGYIERKIEVTN
|. ||||| ||.| ..|...| | .|. .|  .||.||.. ||. .||.|.|  ...  | .||...     . ||....| .|.  . ... | ..|..
egsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkvea

DnkaGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQ
.   .....|.|.. |.|   |  ......| .||.. ..|. . .. .|.|||  ||| |. .|   . .  |.| .   .|||... . | |..  ||
q...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq

TVQQYQGIFQIVLTYL
| .||. ... |. ..
tkeqyelvykavaelv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1095-1299 9e-43 141.8 In-house 87-288 (319) alignment 
Range on Protein: 1095-1299
Range on HMM: 87-288/319.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenknnQEVCYQYWSNR---KLGEYNISLLNEEiHNAGYIERKIEVTNDN
|  ||||| |..||. |. .| |  |. ||  .||.|| . |...||.|       .. | ||| ..   | .......   |   | |. |.||...| 
efsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsve.etaeyvvrdielsedg

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEE-MYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
|  |.....|. .  |   |.   |  .. ...   . |........||.|||  |||.||. .  . ... | |  .||.....  | |..  || . |
kekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvq

YQGIFQIVL
|. |.  .|
ykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1095-1299 1.4e-42 141.2 In-house 51-252 (284) alignment 
Range on Protein: 1095-1299
Range on HMM: 51-252/284.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenknnQEVCYQYWSNRK---LGEYNISLLNEEiHNAGYIERKIEVTNDN
|  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||| ..     .......   |   . |. |.||...| 
efsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsve.eseeyvvrdielsedg

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEE-MYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
|  |.....|. .  |   |.   |  .. ...   . |........||.|||  |||.||. .  . ... | |  .||.....  | |..  || . |
kekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvq

YQGIFQIVL
|. |.  .|
ykfiysall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1095-1300 3.6e-39 129.5 In-house 75-277 (315) alignment 
Range on Protein: 1095-1300
Range on HMM: 75-277/315.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKL--GEYNISLLNEEiHNAGYIERKIEVTNDNK
.| ||.|| ||.||. |. .| |..|  .. ..||... . ... |||| .  ..... . .|| ..|.  |.. ... .|| .|  |  | . |. ...
phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrksee.vnteytvrtlsvvfgdn

AgdkQQVKQYQITNWDsTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
    ..| |...| |  . ....  . |. .    .  ..   ..||.|||. |||.| |..  . ... ..| .|||.....  | .. . ||...|||
i...revvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyq

GIFQIVLT
 |....| 
fiydalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1095-1303 7.6e-39 128.4 In-house 55-269 (274) alignment 
Range on Protein: 1095-1303
Range on HMM: 55-269/274.0
EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKL----GEY-NISLLNEE-IHNAGYIERKIEV
|  .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . . .|.. | .|. ...     ..| .... .|. ... .|  ||. .
edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvl

TNDNKagdKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNT--SIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
 . ..   ...|| |  |.|  .    ...|.| ...|. ...... .   ..|.|||  .|| |.| |.  .... . |.|.||...    |... | |
kyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv

QTVQQYQGIFQIVLTYLD
|| .||. |....  || 
qtseqyelihralclylk
subfamily_PTPN9_pd Subfamily PTPN9 1095-1302 6.2e-36 118.9 In-house 68-290 (297) alignment 
Range on Protein: 1095-1302
Range on HMM: 68-290/297.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS-----NRKLGEYNISLLNEEIHNAgYIERKIEVTN
|. ||||| |..|||.||||| .  |. .| ..||.|. ...|  |||  .   . .  | |||        . |....| .. | ... | .|..|..|
easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleikn

dNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQR---------KRG---NTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQ
  | .....|  .|.. |   |   . ...| |.|.. ..|          ..|   .  ||.|||  .||.| |..   .... ...|..||....|  
.vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkll

RIQKPGSVQTVQQYQGIFQIVLTYL
| |.  |.|| .||.  .. || | 
rtqrafsiqtpeqyefcylavleya
subfamily_PTPRN_pd Subfamily PTPRN 1095-1298 5.2e-28 92.6 In-house 82-288 (297) alignment 
Range on Protein: 1095-1298
Range on HMM: 82-288/297.0
EHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR---KLGEYNISLLNEEIHNAGYIERKIEVTND
|. ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.. .... . |..|| .      . |.. |. | |    |. | . . | 
eksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknl

nKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGnTSIVIHCSDTVGRSGVFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQ
 .. . . | |.    | ..|  ......|     . .. | |  ..||.|||| .||.||...    .|.  |    ||.   |.  | |.|| |.| .
.qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd

QYQGIFQIV
|.. ... |
qfefaltav
0043147 (Phosphotyrosine protein) phosphatases II 1095-1295 9.3e-28 92.5 In-house 3-154 (172) alignment 
Range on Protein: 1095-1295
Range on HMM: 3-154/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQEnknnqevcyqywsnrklgeynisllneeihnagyierkievtNDNKAG
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|...                                            .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

DKQQVKQYQITNWDSTGKLtNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVQQYQG
 .... ||. ..|.  |   ... .| ..| ... . .. .  ...|||  |||.|...||   .        . .......  | ..||.||. .||. 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrf

IF
. 
ly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1095-1302 2.1e-27 90.5 In-house 71-236 (392) alignment 
Range on Protein: 1095-1302
Range on HMM: 71-236/392.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNqevcyqywsnrklgeynisllneeihnagyierkievtndnKAG
 . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. . .. .                                         |  
pdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........................................kgd

DKQQVKQYQITNWDSTGKLTNPQTILLVIEEMyrtQRKRGNTS--IVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
|.. | |...|.|   .      ..| .|.|.   . . |. .  ..||||  |||.||  .  . . ..|.  ..|||...   | ..|  ||| .|| 
dartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqya

GIFQIVLTYL
 |.  ||  |
fiygavledl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1095-1301 5.6e-23 76.0 In-house 64-268 (281) alignment 
Range on Protein: 1095-1301
Range on HMM: 64-268/281.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLLNEEIHNAgYIERKIEVTND--NK
.  ||| | .|     |. .|... |  .|  .||.|| . | ||||||||  . |.| | .|.        ..  |  .  ..  ... .  |      
nstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyeds.tvnkslvttrlnlsy

AGDKQQVKQYQITNWDSTgKLTNPQTILLvieEMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVQQ
 |. . . ..   .|    .. .   ..|   .. |  | |  |  |||||  ||||| . |   ...  ..   . |. |..   |.  .  ||||.||
egetrlithwlwkewpdw.qvpessevml...kilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq

YQGIFQIVLTY
|  |....| .
ymliwkvlldf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1095-1301 3.1e-14 47.3 In-house 77-289 (310) alignment 
Range on Protein: 1095-1301
Range on HMM: 77-289/310.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGE----YNISLLNEEIHNAGYIERKIEVTND
 . ||| | ...    ...|| .. |.  |  .||.|| .    .|..||.  .. .  |  ||    . |      .. |.|  ..    .  .    |
ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpd

NKAGDKQQVK--Q--YQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNtsIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
|   |.|  .  .   .. .|        |.     . .   .| . |    |.|||  ..| .| .|   .|.| .    .|. .|    . ..   .|
nvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciq

TVQQYQGIFQIVLTY
|  ||  | .. . .
telqyliidrvriif
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1096-1310 1.6e-56 186.7 In-house 73-288 (318) alignment 
Range on Protein: 1096-1310
Range on HMM: 73-288/318.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNIS--LLNEEIHNAGYIERKIEVTNdNKA
  ||||| .|.||..|||.| | .|. .| ..||.|. ..| . |||| ||. . .. . .|| ...  .|.     |.||.. . |. |...||. .. 
gsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.tee

GDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQG
 ...||.||..|.|  .| .... ..| .. .  ..|.| |.. ||.|||  ||| |||.|  . ... | |...||||. |  | |..  ||| .||. 
eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyef

IFQIVLTYLDSFETYSN
|....| .| |..|. .
iydvllealasgdtevd
0051299 (Phosphotyrosine protein) phosphatases II 1096-1302 7.8e-56 185.0 In-house 76-286 (288) alignment 
Range on Protein: 1096-1302
Range on HMM: 76-286/288.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS---NRKLGEYNISLLNEEIhNAGYIERKIEVTNDN-
. ||||| .|.||. |..||... |. ||  .||.|. . ||. ||||...  ...| |.|||.     ..|.. . ||.||. ...|. |..|||| . 
gsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldl

--KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQ
  . | ...|.... |||   |  ..|. .|  ...... ..  |.  .|.|||. |||.|.|.|. . ..  ..||..||....|  | |.||.|||..
ldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

QYQGIFQIVLTYL
||. .....| ||
qyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 1096-1302 3.9e-55 182.6 In-house 61-272 (273) alignment 
Range on Protein: 1096-1302
Range on HMM: 61-272/273.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS------NRKLGEYNISLLNEEIhNAGYIERKIEVTN
. ||||| ...||. |..||... |. ||  .||.|. . ||. ||||...  ...| |.|||.        . |.. . ||.||. ...|. |..|.||
gsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltn

DNKAGdKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .    . .|.... |.|   |  .... .|  ||.. .....  .|. .|.|||. |||.|.|.|. . ..  ..|| .||....|  | |.||.|||.
lgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

QQYQGIFQIVLTYL
.||. . ...| ||
eqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1096-1308 8.4e-54 178.3 In-house 70-282 (317) alignment 
Range on Protein: 1096-1308
Range on HMM: 70-282/317.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN---RKLGEYNISLLNEEIhNAGYIERKIEVTNDnK
. ||||| ...|...|..||.. .|. ||  .||.|. . .|| ||||...  ...| |.|||..    . |.. . ||.||  .||.. |..||... .
dsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedl.g

AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
 ... .|.... |.|.  |   .|...|  .|.. . .. .... ...|||. |||.|.|.|| . .. ...|| .||....|  | |.||.||| .||.
dsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyr

GIFQIVLTYLDSFETY
 . ...| ||  ..|.
flydalleylkrkltl
DSPc_SM00195 1096-1302 2e-53 176.8 In-house 53-262 (263) alignment 
Range on Protein: 1096-1302
Range on HMM: 53-262/263.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEIHNAGYIERKIEVTND
. ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||..|..|..| |..|| .      . |.... | ..|.... .| |..|.|..
gsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltke

NKaGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
.|  ....|.|||..||   |   ... .| ...... ....  .. ||.|||. |||.|.|... . ..|...|  .|.|...|. | |.||.||| .|
gk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq

YQGIFQIVLTYL
|. | ...| |.
Ylfiyeaileyi
PTPc_SM00194 1096-1302 2e-53 176.8 In-house 53-262 (263) alignment 
Range on Protein: 1096-1302
Range on HMM: 53-262/263.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEIHNAGYIERKIEVTND
. ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||..|..|..| |..|| .      . |.... | ..|.... .| |..|.|..
gsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltke

NKaGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
.|  ....|.|||..||   |   ... .| ...... ....  .. ||.|||. |||.|.|... . ..|...|  .|.|...|. | |.||.||| .|
gk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq

YQGIFQIVLTYL
|. | ...| |.
Ylfiyeaileyi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1096-1307 9e-52 171.1 In-house 75-288 (319) alignment 
Range on Protein: 1096-1307
Range on HMM: 75-288/319.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLL--NEEIHNAGYIERKIEVTNDNKA
  ||||| ||.||.|...|| . .|. ||  .||.|. ....  .|||.. . . .  . .||.. .  ||   ..  .|| . ..|| ||... . .  
gsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkksse

GDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQG
 .  .||..| |.|   .  .. ...| ..... ....|  .  ||.|||. ||| | |..   .... | |||.|||.. .  |.|..  ||. .||. 
vetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkf

IFQIVLTYLDSFET
|....| ......|
iyealleaveagdt
0039614 (Phosphotyrosine protein) phosphatases II 1096-1306 1e-50 168.3 In-house 84-293 (297) alignment 
Range on Protein: 1096-1306
Range on HMM: 84-293/297.0
HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQeVCYQYWSNR--KLGEYNISLLNEEIhNAGYIERKIEVTNdnk
. ||||| ...||.  ...||..  |. .|  .||.|. . .||.||||.... ...  |.|||...  . |.. . ||..|  ..||. |..||||   
dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkveh.ldgytvrtlevtn...

AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
 |   .|...| |.|   |   .....| ..|.. . ...  ... ...|||. |||.|.|.|| . .. ...|| .||....|  | |.||.||| .||
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

QGIFQIVLTYLDSFE
. .....| .|  . 
rflydallellkrkl
0043336 (Phosphotyrosine protein) phosphatases II 1096-1302 1.1e-49 164.7 In-house 72-277 (278) alignment 
Range on Protein: 1096-1302
Range on HMM: 72-277/278.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSnR---KLGEYNISLLNEEIhNAGYIERKIEVTNdNK
. ||||| ...||. ...||..  |. .|  .||.|. . .|| ||||...  .... |.|||. .   . |.. . ||.||  ...|. |..|||| ..
dsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtn.lg

AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
 | ...| .|. ..|   |  ......|  .... . ..   |. ...|||. |||.|.|.|. . ..  ..|| .|.....|  | |.||.||| .||.
dgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr

GIFQIVLTYL
 .....| ||
flyealleyl
0042113 (Phosphotyrosine protein) phosphatases II 1096-1302 4.6e-47 155.9 In-house 36-243 (245) alignment 
Range on Protein: 1096-1302
Range on HMM: 36-243/245.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR---KLGEYNISLLNEEIhNAGYIERKIEVTNdNK
. ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||..|  .... |.|||...   . |.. . ||.||. ...|. |..|||| ..
dsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseeh.lddytvrtlevtn.lg

AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
 . ...| .|. ..|.  |  ......| ..|.. . ... .|. ...|||. |||.|.|.|| . ..  ..|. .......|  | |.||.||| .||.
ddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyr

GIFQIVLTYL
 . ...| .|
flyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1096-1304 9.5e-45 147.9 In-house 68-278 (281) alignment 
Range on Protein: 1096-1304
Range on HMM: 68-278/281.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK----LGEYNISLLNEEiHNAGYIERKIEVtnDN
. ||||| |..|||..|..|....|. ..  .||.|. ...|.||||. .| ....  |..|| . .    .|.. .. ..|| ..| |||||...  ..
ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl..er

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQ
. |....|.| . |.|  .|  .... .|   .|......|. ....|||||  |||.|.. |  . ......|   .|| .|... | ..   |||| |
esgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq

YQGIFQIVLTYLDS
|. ....|| .|| 
yefvykavldaldk
subfamily_PTPRK_pd Subfamily PTPRK 1096-1300 5.4e-43 142.0 In-house 70-275 (314) alignment 
Range on Protein: 1096-1300
Range on HMM: 70-275/314.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN--RKLGEYNISLLNEEIhNAGYIERKIEVTN-DNK
. ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  .. .  |..|| .  .. |. .. |.. |. .| .. |   |..   .
ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetel.laelvvrifrveklarg

AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
  ....|.|.| ..| . .  .. ...| .. ..  .| . ..  ||.|||   ||.|.|.| .. ..  ..|||.|||.. |. | .|.  |.| .||.
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqyk

GIFQIVLT
 |....| 
fiydvile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1096-1303 1.3e-41 137.5 In-house 71-278 (315) alignment 
Range on Protein: 1096-1303
Range on HMM: 71-278/315.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN-----RKLGEYNISLLNEEIhNAGYIERKIeVTNd
. ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .....  | ||| .      ..|.....||. |  ... . ||. ||  
dsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarkl.vtr.

nKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
 |. ....| |.| |.|   |   .  ..| .| |.    ... . |...|||  |||.||....   ... | . ..|||...|  | ..|  ||| ..
.kseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteee

YQGIFQIVLTYLD
|  |...|| .| 
yafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1096-1303 5.8e-41 135.1 In-house 70-277 (515) alignment 
Range on Protein: 1096-1303
Range on HMM: 70-277/515.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN-----RKLGEYNISLLNEEIhNAGYIERKIEVTND
| ||.|| .|....  ||.| .  |   .  .||... . |||.|.|. . .....  | .|| .      |.|.....|.  |   .| | ||..|. .
hsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea.ctggikrkltvlkg

NKagdKQQVKQYQITNWDSTGKLTNPQTILLVIEEMyRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
..    . | |.. |.|   |   . ...| .| |. .... . . ...||||  ||| ||....   . . ||  ..|||....  | ..|  ||| .|
dd...srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq

YQGIFQIVLTYLD
|  |...|| .| 
yafiygavledll
0037934 (Phosphotyrosine protein) phosphatases II 1096-1301 1.4e-40 134.7 In-house 31-241 (243) alignment 
Range on Protein: 1096-1301
Range on HMM: 31-241/243.0
HPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLLNEEIHNAGYIERKIEVTNDN
  ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||...  ...| |.|||.. .  .  .  | .| | ..|. |.....| .
gsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenld

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-------RGNTSIVIHCSDTVGRSGVFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-
  . ...| .|. ..|   |  ..|. .|  ..|..  ...        ..  ...|||  |||.|...|| . . ..   | .|.....|  | |.|| 
lddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgk

SVQTVQQYQGIFQIVLTY
.||| .||. . ...| .
avqtpsqyrflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 1096-1304 1.5e-40 134.0 In-house 78-287 (293) alignment 
Range on Protein: 1096-1304
Range on HMM: 78-287/293.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR----KLGEYNISLLNEEiHNAGYIERKIEVTNdn
. ||||| .|.||. .. || .  |. .|  .||.|. ......|||| |   . .. | .|| .       |. ...|..|| .   .. |......  
gsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee.eledwvirelkiek..

kAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQ-RKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
 . ....|.||. | |   |   ...|.|  .... ... ..  .. ||.|||  |||.|.| |  . ... ..| ..|.| .. . | ..   |||..|
.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YQGIFQIVLTYLDS
|  | | ||..| .
Yifihqcvldllrk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1096-1304 1.7e-39 130.8 In-house 75-290 (325) alignment 
Range on Protein: 1096-1304
Range on HMM: 75-290/325.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEIHnAGYIERKIEVTNd
. ||||| ... .|.|. |. | .|. .|  ..|... | . ...|..  | ..... | .|| ..     ..|  ...|   |   . |. |...| . 
ssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkq.

NKAGDKQQVKQYQITNWDSTGKLTNPQTILLVI---EEMYRTQR--KRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
 | |. . |||.|.  ||  |    | |.. ..   ...  . .   .. | |..|||. |||.||| .  . ..|  .|  .|.|...|  | ..|  |
vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmv

QTVQQYQGIFQIVLTYLDS
.|| ||  |.. .  .. |
etvdqyiliyealveayms
subfamily_CG7180_pd Subfamily CG7180 1096-1302 1.5e-38 127.1 In-house 69-290 (296) alignment 
Range on Protein: 1096-1302
Range on HMM: 69-290/296.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQeVCYQYWSNR---KLGEYNISLLNEEIHNAGY-----IERKIEV
. ||||||.....  ||..|. | |. .|  .||... |... |.|.|...   ..  . .|| |.   . ||  . ...|.   .       . .||  
ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkiva

T---NDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG-----NTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRI
.   . .   ..  ||..|.| |..  |.    . |. . .. |. |..      .  .|...|| ..||||..|.  .... . |. .|||. .|  |.
lteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrr

QKPGSVQTVQQYQGIFQIVLTYL
..|. |..|..|. |....| ..
sRpqLvenveeYkyiYdvlleav
0051429 (Phosphotyrosine protein) phosphatases II 1096-1305 2e-31 105.0 In-house 3-228 (272) alignment 
Range on Protein: 1096-1305
Range on HMM: 3-228/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLLNEE--------------IHNA
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.  ... |..|| . ..  ..|    ..              ..  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKLTNPqtILLVIEEMYRtqrkrgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVID--------V
 || |....|.  .||.  .| ... |.|   |  ...  .| ..|.. .      .  ...|||  ..|.|...|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
.....  | | ||.||| .||. .....| .|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPN14_pd Subfamily PTPN14 1096-1303 7.8e-26 85.7 In-house 75-297 (300) alignment 
Range on Protein: 1096-1303
Range on HMM: 75-297/300.0
HPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-------KLGEYNISLLNEEiHNAGYIERKIE
. .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| .|... .| ...|. .        . |.....    | .   .| ....
stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfse.dsdsvittglk

VTNdNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNT--------SIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQR
.     ......|   | |.|   |   .... |  .||.   .||  ..         ...|||. |||.||   .   |.  ... .||. .||.  |
lkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLr

IQKPGSVQTVQQYQGIFQIVLTYLD
 |.   |||. ||. .......||.
eqrmllvqtlaqYkfvYkvlikylk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1096-1299 2.7e-25 83.9 In-house 34-237 (239) alignment 
Range on Protein: 1096-1299
Range on HMM: 34-237/239.0
HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS--NRKLGEYNISLLNEEIHnAGYIERKIEVTNDnK
| ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    .  .. |.|||     |  .  ..| . |.  | || | . ...   
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevf.adyiirtfvmsqv.g

AGDKQQVKQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
  ... | ||..| |   |      | .| .      .   |    |||||  |||.| |    . . ..| .  .|.|. .|. | ..|  ||| .|| 
qteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyv

GIFQIVL
 |.  ||
fihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1096-1299 3e-25 83.8 In-house 35-238 (239) alignment 
Range on Protein: 1096-1299
Range on HMM: 35-238/239.0
HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWS--NRKLGEYNISLLNEEIHnAGYIERKIEVTNDnK
| ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    .  .. |.|||     |  .  ..| . |.  | || | . ...   
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevf.adyiirtfvmsqv.g

AGDKQQVKQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
  ... | ||..| |   |      | .| .      .   |    |||||  |||.| |    . . ..| .  .|.|. .|. | ..|  ||| .|| 
qteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyv

GIFQIVL
 |.  ||
fihlavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1096-1300 8.7e-24 78.8 In-house 75-277 (439) alignment 
Range on Protein: 1096-1300
Range on HMM: 75-277/439.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenknNQEVCYQYWSNRKLGEY-NIS-LLNEEIHNAGYIERKIEVTNDNKA
|  |||| .|.|| ..| .| .. |  .|. .||... ..... ||||.     |    |.||   .   | .|.   . .|    |. | . | |.   
hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt.....nlvesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdt

GDKQ-QVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
..|.  | |.. . |      ..   .|  .  .  .. |.    .|.|||  |||.|   |   .... |.|  .|.  ..|  | |.   ||.. || 
tekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyv

GIFQIVLT
 |.. || 
fiynavle
0051082 (Phosphotyrosine protein) phosphatases II 1096-1296 9.3e-22 72.7 In-house 2-147 (151) alignment 
Range on Protein: 1096-1296
Range on HMM: 2-147/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCQENKNNqeVCYQYWSNRKlgeynisllneeihnagyierkievtndnkagd
..||||. .. |.     ...   |       |.... . ....||.|..|  ..   |..|. .                                   
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

kQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRtqrkRGNTSIVIHCSDTVGRSGVFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQGIF
  .|....|..|. .|  ......| ..|.. .     .|  ...|||  .||.|...|.   . .      ......|.  |.. ||.||. ||.. ..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

Q
.
f
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1096-1302 2.3e-13 44.3 In-house 74-285 (302) alignment 
Range on Protein: 1096-1302
Range on HMM: 74-285/302.0
HPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCQENKNNQeVCYQYWS--NRKLGEYNISLLNE----EIHNAGyIERKIE
  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.| .|.. ..    ...     .  ||.   .|     . ...   .  ||
pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviE

VTNDNKAgDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
|  .. . .   .. | .||| ..  ...  ..   .....      .. ..||     .|| |.| ..|....| ...    . ...|| | |.| .|.
vlPegcs.nsvlanvyvltnWkqkkvpvkyaeliktaakvfak.kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravd

TVQQYQGIFQIVLTYL
...||  .. ..|.|.
slkQyvslyialllyi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1097-1309 4.9e-112 368.5 In-house 72-290 (290) alignment 
Range on Protein: 1097-1309
Range on HMM: 72-290/290.0
P----DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR---KLGEYNISLLNEEIHNaGYIERKIEVTN
.    .||||..|.||||||..|....|..||...|||.|....||.||||..........|.|||...   ..||..| |||||..| .|||||.||.|
kDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevkn

DNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQ
.|.||.||.|.||||||||||||.||||||||||||||.|||||||||||.|||||||||.|||||||||||||||||||||||||||||||||||||||
knsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq

QYQGIFQIVLTYLDSFETYS
||||||||||||||||||||
qyqgifqivltyldsfetys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1097-1307 6.3e-66 217.6 In-house 74-288 (305) alignment 
Range on Protein: 1097-1307
Range on HMM: 74-288/305.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEiHNAGYIERKIEVTNDN
 ||||| ...|||.||..|.| .|. || ..||..| .  |. ||||..  ..... |.||| ..     ..||... | .|. . ..|||||.......
sdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek.tasdyieRklkisied

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
.  ....| |||.|.|   |  . . ..| .|... ..|.|  ......|||..|||.|||.|    ....|.|.|.|||.|||  | .... ||| .||
edkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqY

QGIFQIVLTYLDSFET
. .....  .. ...|
vflhdaldelitcgdt
0040439 (Phosphotyrosine protein) phosphatases II 1097-1302 1.1e-46 154.8 In-house 39-246 (249) alignment 
Range on Protein: 1097-1302
Range on HMM: 39-246/249.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN---RKLGEYNISLLNEEIhNAGYIERKIEVTNDnKA
 ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||...  ...| |.|||..    . |.. . ||..|. ...|. |..|.||  . 
sdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvev.kddytvrtleltnl.yd

GDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
|.. .|...|.|.|  .|   .....|  ||..   ...   .. ...|||. |||.|.|.|| . ..  ..|. .|.....|  | |.||.||. .||.
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

GIFQIVLTYL
 . ...| .|
flyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1097-1307 3.2e-43 142.9 In-house 79-289 (297) alignment 
Range on Protein: 1097-1307
Range on HMM: 79-289/297.0
PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQeVCYQYWSNRKLGEY-NISLLNEEIH-NAGYIERKIEVTNdNKAG
 ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..|....  | .|||..   .. ..|.. . ..   |.|.|..|||. .|| 
sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkak

DKQQVKQYQITNWDSTGKLT--NPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
 .. ||||| ..| .       . ...| .|.|.  .  .. .. ...||.  ||| ||...    . . | |  .|.|...|  | ..|  ||| .||.
arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqyk

GIFQIVLTYLDSFET
 ....|| .| | .|
fvyvavleallsedt
subfamily_PTPRG_pd Subfamily PTPRG 1097-1307 4.4e-42 139.0 In-house 76-292 (563) alignment 
Range on Protein: 1097-1307
Range on HMM: 76-292/563.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN---RKLGEYNISLLNEEIHnAGYIERKIEVTN-DNK
 ||||| .|.||. .||||..  |. .|.  ||.|| ..||. |||. . ...... | .|| .    ..|. .. | .||.. | | .|.. . |   |
lDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevl.alytvrtlviknlklk

AG----DKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..    ....|.||. |.|  .|  . .   |  ..   .....     ||.|||  |||.|....  | ... ..| ...||..||  | |..  ||| 
kkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte

QQYQGIFQIVLTYLDSFET
 ||. .....|  . | ||
EqYiflhdalleaiasket
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1097-1306 7.3e-40 131.8 In-house 75-285 (288) alignment 
Range on Protein: 1097-1306
Range on HMM: 75-285/288.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR----KLGEYNISLLNEEiHNAGYIERKIEVTndnK
 ||||| .|.|.|.||..| . .|. .|  .||... ..... |||| .   .... | .|| .     . |. .. |.... .   ...||...    |
aDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfvlrkllle...k

AGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
 ... ...||| . |  .|   . . .| ... .  .. .     |..|||. |||.|.| |. . |.. ..| .|||. ...  | |..  |||..||.
kkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYe

GIFQIVLTYL--DSFE
 |....|.    |. .
fiyevllslieedgva
subfamily_PTPN6_pd Subfamily PTPN6 1097-1304 1.7e-36 120.8 In-house 81-299 (306) alignment 
Range on Protein: 1097-1304
Range on HMM: 81-299/306.0
PDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN----RKLGEYNISLLNEeIHNAGYIERKIEVTND
 ||||| .|..   ...|..| ..  . .|  .||.|. . | . |||. .|.  ..| |..|| .    .. |..... ..|  ..| || |.. |.. 
sdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskk

NKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG---NTSIVIHCSDTVGRSGVFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGS
.|......| ||. ..|   |  ..|...|  .|.. | |..     . .||.|||. .|| | |    . ... ...|.   ||. .. || | |. | 
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

VQTVQQYQGIFQIVLTYLDS
||| |||. ..... .|...
vqteqqykfvykaikkyiet
subfamily_PTPN23_pd Subfamily PTPN23 1097-1302 1.6e-35 117.4 In-house 67-280 (288) alignment 
Range on Protein: 1097-1302
Range on HMM: 67-280/288.0
PDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEiHNAGYIERKIEVTND
 ||||| |...       ||.. .|. .|.  ||.|. .. .  |||| .... ... . .|| ..     | |.....| ... .   ..||.....  
DDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletl

nKAGDKQQVKQYQITNWDSTGKLTNPQTILLVI---EEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQ
 .|  ...|.  |.|.| . |    |.|.| ..   |..|...... .| .|.|||  |||.|||.   . ... .  .|..|. ||..  | |.  .||
.dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvq

TVQQYQGIFQIVLTYL
...|..  ...||.. 
ekeqlkfsyeavleaa
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1097-1303 2.5e-35 116.8 In-house 48-265 (270) alignment 
Range on Protein: 1097-1303
Range on HMM: 48-265/270.0
PDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLG-----EYNISLLNEE-IHNAGYIERKIEVTn
  |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . . .... | .||....       . .|. |...  .. ||| ...... 
taYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.

dnKAGDKQQVKQYQITNWDSTGKLT------NPQTILLVIEEMYRTQRKRGN-TSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
  . |.....  .. ..|   |  .      ... .| ..... |....  . . ...|||. |||.|.. |  ....  .... .|| ....  | ...
..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRm

GSVQTVQQYQGIFQIVLTYLD
  ||...||. ... |..| .
alvqhpeqyeflykavveyae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1097-1303 9.8e-34 111.4 In-house 65-278 (287) alignment 
Range on Protein: 1097-1303
Range on HMM: 65-278/287.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR----KLGEYNISLLNEEIHNAGYIERKIEVTNdNK
 ||||| .. .|....||| | .|.  | |.||... .......... .| .. .  ||.|| .|    ..| | . ||. .| .  |  | . . .  .
sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid.le

AGDKQQVKQYQITNWdsTGKLTNPQ---TILLVIE--EMYRTQRK-RGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
. . . |||... .|    |   |     | .|..  .    .|.  .   .|.|..  .||||.. |  . ... .  | .|| .|.   | .. . ||
trearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvq

TVQQYQGIFQIVLTYLD
.| |.. ... . ||  
avvqlrllyealvtyyk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1097-1299 3.9e-27 90.0 In-house 29-236 (237) alignment 
Range on Protein: 1097-1299
Range on HMM: 29-236/237.0
PDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN----RKLGEYNISLLNEEIHnAGYIERKIEVTNDN
 ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    ..|.. |..|| .    .  | . .||  .|   . |  | . ...  
sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeef.sdytvrslllskrl

KAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-RGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
.  . . ..|||.| |   |   .  ..|    ..    ..    .  .||||  |||.|.|    . . ..| . |.|... ..|   ..|  .|| .|
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

YQGIFQIVL
|  |.| .|
yvfihqtil
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1097-1305 2.2e-25 83.9 In-house 81-286 (290) alignment 
Range on Protein: 1097-1305
Range on HMM: 81-286/290.0
PDYINAVFINGYKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK-----LGEYNISLLNEEIHNAGYIERKIEVTnDN
 ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||.  .. .  | ||. ...     .||. .   .|. ..|  | . . |  | 
GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvr.dk

KAGDKQQVKQYQITNWDSTGkLTNPQtiLLVIeEMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVQQ
..| . ..| ..|  |     ... .  | ..  . |. ||  .  .|.|||  .||.| | |  ... .. ..|  .|. .. .. |  . .|||   |
dsGkehklkhlkikswpdks.valst..lall.rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiq

YQGIFQIVLTYLDSF
|  . .|.| .  .|
ylalveilldlGkdf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1097-1309 1.9e-22 74.7 In-house 67-286 (307) alignment 
Range on Protein: 1097-1309
Range on HMM: 67-286/307.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKL-----G--EYNISLLNEEIHNAGYIERKIEVTN
 ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.  .  .  | |||   .      |     ||. |  ...    |  |.||.
sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvtt

DN--KAGDKQQVKQYQITNWDSTGkltNPQTILLVIEEMYRTQRKrgNTSIVIHCSDTVGRSGVFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQ
 .   |.. . ....| .||   |    ||. |  |. .  .. .  .  .|.|||  |||||   | .   .|  . .   |. ....  | |.. ..|
lkvdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq

TVQQYQGIFQIVLTYL-DSF-ETYS
|  ||  . ...| |. . . ||| 
teaqylylhrvlleyflelyketye
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1097-1302 9.4e-19 62.2 In-house 80-289 (305) alignment 
Range on Protein: 1097-1302
Range on HMM: 80-289/305.0
PDYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGE--YNISLLNEEIHNAGYIERKIE--VTNDN
 ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  .  .  | |||   .      .  .. |..  .  .||  |  .|  |
sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitlln

--K-AGDKQQVKQYQITNWDSTGKltnPQTILLVIEEMyRTQRkRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQT
     ..|  |.. | |.|   |    |   |  .| .  . |   .  ||.|||  .||.|   |    ..|   .  .  . ...|. | |.  |.|.
ltysgdqkmsvrhlqwtewpdrgv...ppckltslell.sair.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqn

VQQYQGIFQIVLTYL
  ||  | ...| |.
dvqylfihrvmlnyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1097-1173 4.6e-11 37.0 In-house 83-165 (350) alignment 
Range on Protein: 1097-1173
Range on HMM: 83-165/350.0
PDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLLNE
 ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..| ..  .| | ||.|| . .  .... | . 
nDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklask
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1097-1162 7.9e-11 36.3 In-house 59-126 (297) alignment 
Range on Protein: 1097-1162
Range on HMM: 59-126/297.0
PDYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK
 ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... ... .. |. || . .
rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1097-1152 5.6e-06 20.0 In-house 60-117 (332) alignment 
Range on Protein: 1097-1152
Range on HMM: 60-117/332.0
PDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCQE-NKNNQE
 |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |... .  .|....
ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1098-1310 2.9e-61 201.8 In-house 71-301 (301) alignment 
Range on Protein: 1098-1310
Range on HMM: 71-301/301.0
DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN-----RKLGEYNISLLNEE----------------IH
.|||| .|.||.|||.||.|..|| .| ..||..| .  ...|||....... .. |.|||.|      . |. .. | ||                   
eyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgs

NAGYIERKIEVTNDNkagDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKS
| ||||||..|..|.   . ..| |.|.|.|   | . .|.|.| ||...  .|.| |   .|.||||||.||||.|.   ..  || |||.||||| |.
nngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtka

QRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
 | .||| |.| .||  |.... .||   .||.|
vrrskpgaVtTLeqytsiydvidmylqlnstyan
0045098 (Phosphotyrosine protein) phosphatases II 1098-1303 1.2e-46 154.7 In-house 52-273 (278) alignment 
Range on Protein: 1098-1303
Range on HMM: 52-273/278.0
DYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSN---RKLGEYNISLLNEEIHnAGYIERKIEVTND---N
||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||...  ...| |.||| .      |.. . ||.||..   |. |...|||     
dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltver

KAGDKQQVKQYQITNWDSTGKLTNP--QTILLVIEEMYRTQR------------KRGNTSIVIHCSDTVGRSGVFCAAATTINKCktEGVIDVFQVLKSQ
. . .  |.......|.  |  ..|  . .| ..|.. . ..              ... ...|||  |||.|...|| . .  .  ||..|.....|  
edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkel

RIQKPG-SVQTVQQYQGIFQIVLTYLD
| |.|| .||. .||. ... .| .| 
rsqRpglavqnleqyrflyefllelll
0036282 (Phosphotyrosine protein) phosphatases II 1098-1296 1.2e-32 108.4 In-house 3-164 (174) alignment 
Range on Protein: 1098-1296
Range on HMM: 3-164/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNrklgeynisllneeihnagyierkievtndNKAGDKQ
||||| .....   . .|.   |.      ||.|. . ..|..|||..|. .. . |..||.                               ..   ..
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredler

QVKQYQITNWDSTGKLTNPQtILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
 . ||. ..|.  |  . .. .| ....... . . ..  ...|||  |||.|...||   .   . |...|........| |.||.||| .||. . .
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0049772 (Phosphotyrosine protein) phosphatases II 1098-1308 3.7e-24 81.4 In-house 73-286 (314) alignment 
Range on Protein: 1098-1308
Range on HMM: 73-286/314.0
DYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM---------------------LCQENKNNQEVCYQYWSNRKlg
||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||                     |..   |. | . ... . |  
dyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..

eynisllneeihnagyierkiEVTNDNKAGdKQQVKQYQITNWDStGKLTNPQTILLVIEEMYRTqrkRGNTSIVIHCSDTVGRSGVFCAAATTINKCkt
                     |...|..   .... .|  ....  |    .. .. ..| . .    . .. ...||.. .||.|.|..||  . ..  
.....................eelydpelf.erlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll..

eGViDVFQVLKSQRIQKP-----GSVQTVQQYQGIFQIVLTYLDSFETY
 || .. ..|.  | . |     |.... .||. |....| ||. ....
.gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1098-1303 1.8e-16 54.7 In-house 74-288 (305) alignment 
Range on Protein: 1098-1303
Range on HMM: 74-288/305.0
DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEY-------NISLLNEEIHNAGYIE------RK
.|| | ..    . | || ...|. .|  .|| |  . .| || |||.  .   . |..|.. ..  .         ||.  |  ..  . .      ..
eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvte

IEVTNDNKAGDKQQVKQYQITNWDSTGKLTNPQTillVIEEMYRTQRKRGntSIVIHCSDTVGRSGVFCAAATTINKCKTEGVID-VFQVLKSQRIQKPG
 ... .   .....|..|   .|   |  .  ..   ..| . ...  .|   ||.|||  .||.|        ...  .  .|.   ..|.  | |.  
tvlviegpgekarkvthyhwidwpdrgvpaadla...ilellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnn

SVQTVQQYQGIFQIVLTYLD
|.|| .||  . |..| |. 
siqtdaqylfvhqvilnyfr
subfamily_egg_pd Subfamily egg 1098-1302 1.2e-15 52.0 In-house 69-270 (307) alignment 
Range on Protein: 1098-1302
Range on HMM: 69-270/307.0
DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNnqEVCYQYWSNRKLGEYNI---SLLNEEIHNAGYIERKIEVTNDNKAG
|.| |  ..|      ||.|..|. ||  .||.|.   .|  ||||    ..  | |  || . .     .   ||  | ..     .    ||. .  |
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG

DKQ---QVKQYQiTNWDSTGKLTNPQTILlvieemyRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTV
 ..    .. .|  ... ....  |  .|       |  |.   . .|... . | ..... |. ... .    | |  . ||..    | ... ||..|
gddeerflehwq.gdvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesv

QQYQGIFQIVLTYL
 .|  ....|| ..
llylfvyrlvlfff
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1098-1299 7.9e-15 49.7 In-house 47-256 (290) alignment 
Range on Protein: 1098-1299
Range on HMM: 47-256/290.0
DYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCQENKNNQE----VCYQYWSNRKL-----GEYNISLlNEEIHNAGYI
||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||. ......     | .|  ..       .  ...   . ... . .
dyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddve

ERKIEVTNDNKagDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVIHCSDTVGRSGVFCAAATTINKCK-TEGVIDVFQVLKSQRIQ
.|...|. |..   . .|. ... .|...    ...|.| .|. .     |  .| ...|| | . || .. |      |   |.| . . .|||. | |
tRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

KPGSVQTVQQYQGIFQIVL
.   ... ...  .   ..
ralaitsalelafvdagiv
subfamily_CG42327_pd Subfamily CG42327 1098-1175 2.6e-10 34.5 In-house 57-142 (319) alignment 
Range on Protein: 1098-1175
Range on HMM: 57-142/319.0
DYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRK-------LGEYNISLLNEEI
 |..| .. ||.. .. .| |. .. ... .||... ...   || |..  ..  .|| .|.  ..        |.. ..| . |.
eyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1098-1193 4.8e-09 30.0 In-house 91-188 (349) alignment 
Range on Protein: 1098-1193
Range on HMM: 91-188/349.0
DYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNISLLNEEIHNAGYIERKIEVTNDNKA
||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...... | |..|| . .  .... | |   . |.      .| .....
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1098-1219 1.3e-08 28.8 In-house 123-242 (244) alignment 
Range on Protein: 1098-1219
Range on HMM: 123-242/244.0
DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQevcyqYWSNRKLGE-Y--NISLLN---EEIHNAGYieRKIEVTNDN
 |||| |.        .|... |. .|. .||||. .| |  .|.|   .....     || . .  | |  .|..     .|..|      ..|.  | 
tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknika..snleiesdm

KaGDKQQVKQYQITNWDSTGKLTNPQTI
.   .| .  .||.|| | |   |   |
n.eshqaltmfqisnwpsdgttpndhfi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1098-1148 1.9e-06 21.7 In-house 71-121 (347) alignment 
Range on Protein: 1098-1148
Range on HMM: 71-121/347.0
DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENK
 ||||  |.  . .| .|... |. .| |.||||.   .|| .| . .  |
tyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1100-1290 5.5e-24 79.4 In-house 78-269 (301) alignment 
Range on Protein: 1100-1290
Range on HMM: 78-269/301.0
INAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNE-EIHNAGYIERKIEVTNDNKA
| | .|.   . . ||.. .|. ||. .|| |.   .|  ||||.|. ....|.| .| . .     ..| ..| . |.  | |   ..|..||..  . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GDKQQVKQYQITNWDSTGkltNPQTILLVIEEMYRTqrKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
 . . |  || ..|   |    |..   . . |     |. .  ||.|||. .|||  | ..    .. ...  |.. . ||  | ..  .|||..|
fatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
0049260 (Phosphotyrosine protein) phosphatases II 1104-1295 1.5e-26 88.3 In-house 1-143 (152) alignment 
Range on Protein: 1104-1295
Range on HMM: 1-143/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWsnrklgeynisllneeihnagyierkievtndnkagdkqqvkQYQ
||.||. ...||... |. ||. .||.|. . ..|.||||...  .. . |.||.                                          ||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

ITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVIHCSDTVGRSGVFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
 ..|.  |  ...| .| ... . .  ... .  ...|||  |||.|...||   .        ........  | ..||.|.. .|.. ..
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1105-1159 7.9e-08 26.0 In-house 229-280 (440) alignment 
Range on Protein: 1105-1159
Range on HMM: 229-280/440.0
INGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQEnknNQEVCYQYWS
..||  |.||| .. |.  |  .||... | ....|.|| |    |.  |  || 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1109-1297 1.2e-16 55.5 In-house 2-199 (199) alignment 
Range on Protein: 1109-1297
Range on HMM: 2-199/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKL--GEYN-ISLLNEEIH-NAGYIERKIEVTNDNKAG-DKQQVKQYQ
| .. .| .. |. .|  .||.|. .     |||. ...||..     ||.  .   |.|  .|.  . |  .. |    . .||.  |    ... .||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWDST--GKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
.| |      ...    ...   |. .   .  .. ...||||  | .||| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1110-1297 1.5e-16 55.1 In-house 2-198 (198) alignment 
Range on Protein: 1110-1297
Range on HMM: 2-198/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKL--GEYN-ISLLNEEIH-NAGYIERKIEVTNDNKAG-DKQQVKQYQI
 .. .| .. |. .|  .||.|. .     |||. ...||..     ||.  .   |.|  .|.  . |  .. |    . .||.  |    ... .||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWDST--GKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
| |      ...    ...   |. .   .  .. ...||||  | .||| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1112-1302 8.6e-08 25.2 In-house 115-309 (346) alignment 
Range on Protein: 1112-1302
Range on HMM: 115-309/346.0
KAFIIAESPMFNT---ARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEYNIS--LLNEEIHNAG-YIERKIEVTNDNKAgDKQQVKQYQIT
. .|.|. | ..      .|| || . ..  . ..  ..| ..     .  .    .|     . |     .|   |  |||  . .. |   .. .. .
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegns.dsvicqvhhha

NWDSTGKLTNPQTILLVIEEMYrTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 |    .  .   |. .| ... ....  |. . .      ||.  |  |  .||.       ......|. . |.||.|..  || .|. ||. |.
pwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_hpo-7_pd Subfamily hpo-7 1116-1301 2.5e-12 41.3 In-house 42-226 (263) alignment 
Range on Protein: 1116-1301
Range on HMM: 42-226/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGE-----YNISLLNeEIHnaGYIERKIEVTN--DNkAGDKQQVKQYQITNWD
.    . .|  .|...|   . . .||||  | ...| | .|.   | .       |..  .  ..    . . .|...  ..     ..||.|. . | 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttk.vqs..dvllktlellstlge.KkkthtvkhysykgWi

STGKLTNPQTILLVIeemyRTQRKRgnTSIVIHCSDTVGRSGVFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 .   .... || ..    .  |.    |.|.|||  .|||  |  | .          . .| . .|  ..|.  | .......|  |    . .||..
ekndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1117-1295 2.6e-16 53.9 In-house 96-281 (302) alignment 
Range on Protein: 1117-1295
Range on HMM: 96-281/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNR-----KLGEYNISLLNEEIHNAGYIE------RKIEVTNDNKAG-DKQQVKQYQI
   |  .|   .| .|.. ||. .| ||.  ..... | .|.|..     |.|.| .  .. . . . . .       ..|..|..|    |. |.  . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGKLTNPQTILLVIEemYRTQRKrgnTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. |   |   ...| | ..   .    |   .....|||  |||.| . |    |. |... | |. ....  |  . |.||. ||   ..
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1117-1302 3e-12 41.2 In-house 39-221 (255) alignment 
Range on Protein: 1117-1302
Range on HMM: 39-221/255.0
AespmfnTARNFWKMIDDRNVTAIVMLCQENKNNQEVCYQYWSNRKLGEY-----NISLLNeeiHNAGYIERKIEVTNDNK-AGDKQQVKQYQITNWDST
       |  .|...|   . . .||||  . ...| | .|.   | .       |..  .     |  . | .|.|         ..|| |. . |   
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWiek

GKLTNPQTILLVieemYRTQRKRgnTSIVIHCSDTVGRSGVFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
    ... || .    ..  |.    |.|.|||  .|||  |  |            . .| . .|  ..|.  | .......|  |    . .||...
naPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlv
0048179 (Phosphotyrosine protein) phosphatases II 1132-1295 7.5e-13 43.9 In-house 25-138 (144) alignment 
Range on Protein: 1132-1295
Range on HMM: 25-138/144.0
IDDRNVTAIVMLCQENKNNQEVCYqywsnrklgeynisllneeihnagyierkievtndnkagdkqqVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQR
. . ..|... |. |  .. . ..                                           . ||. ..|.  |  . .. .| ..| . . ..
lkklgittvinlteeyepeflere...........................................giqylhlpwpDhgvpdllellleflefieeale

krGNTSIVIHCSDTVGRSGVFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIF
   .  ...|||  |||.|...||   .    ..| ......|.  | . ||.|.. .|.. . 
..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 1181-1299 3.1e-13 45.1 In-house 30-140 (145) alignment 
Range on Protein: 1181-1299
Range on HMM: 30-140/145.0
IERKIEVtNDNKAGDKQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrgNTSIVIHCSDTVGRSGVFCAAATTINkcktEGvIDVFQVLKSQRIQ
| . . .  ... . .... ||. ..|.  |  . ....| ..| . . ...  .  ...|||  |||.|...||   .     .| ......|.  | |
ittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsq

KPGSVQTVQQYQGIFQIVL
 ||.|....|.. ... .|
rpgavpnpgqlrflyefel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1193-1260 1.7e-07 25.3 In-house 211-287 (350) alignment 
Range on Protein: 1193-1260
Range on HMM: 211-287/350.0
AGDKQQVKQYQITNWDSTGKLTNPQTILLVIE--------EMYR--TQRKRGnTSIVIHCSDTVGRSGVFCAAATTIN
| |   | | |. ||   . | ||. || ..|         . .   . .|. ..|..|||  ||| |....    ..
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDslls
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1196-1302 1.4e-14 48.3 In-house 88-194 (440) alignment 
Range on Protein: 1196-1302
Range on HMM: 88-194/440.0
KQQVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
 . .|||.   |   |       .| .|...  .| | ||  ...|||  .||.||  |  . . ..|    ||.| ...| | ..|  ||| .||  ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QIVLTYL
. ||  |
eavlegl
PTPc_DSPc_SM00012 1198-1298 1.4e-22 75.3 In-house 1-103 (105) alignment 
Range on Protein: 1198-1298
Range on HMM: 1-103/105.0
QVKQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG-NTSIVIHCSDTVGRSGVFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
.||.|..|.|  .|. .... || ..... . ..|.. ....|.|||. |||.|.|.|... ......| . .|.||..|. | |.||.||| .||. . 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QIV
...
ral
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1198-1260 3e-06 20.8 In-house 219-290 (349) alignment 
Range on Protein: 1198-1260
Range on HMM: 219-290/349.0
QVKQYQITNWDSTGKLTNPQTILLVIE-------EMY-RTQR-KRGNTSIVIHCSDTVGRSGVFCAAATTIN
.. | |. ||  .. | ||..||  .|       ... |    .   .....|||   ||.||..     ..
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1225-1301 1.8e-11 38.4 In-house 219-294 (297) alignment 
Range on Protein: 1225-1301
Range on HMM: 219-294/297.0
EMYRTQRKRgNTSIVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
| .|..  | |. ...|||  ||||||   . . ..| . . . ||  .|.  | |..  |||..|.. ....||  
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_CG42327_pd Subfamily CG42327 1230-1301 7.5e-09 29.7 In-house 242-314 (319) alignment 
Range on Protein: 1230-1301
Range on HMM: 242-314/319.0
QRKRGNTSIVIHCSDTVGRSGVFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 ..  .  .|.|||| |||.|.  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1238-1291 8e-06 20.2 In-house 1-54 (69) alignment 
Range on Protein: 1238-1291
Range on HMM: 1-54/69.0
IVIHCSDTVGRSGVFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
.|.|||   ||.| | |    . . |.| ..|.|  ..  |  .|  |   ..|
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneiey