Gene PTPRD-26 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP080_AA protein Get Run
AqueP080_AA_591-821 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 105-177 1.9e-06 21.1 Pfam-A 2-77 (85) alignment
Range on Protein: 105-177
Range on HMM: 2-77/85.0
TPTGLTATRLNTGVAHVRLSWST--VSGATGYEVYYYQLSSNT-PVSVSNTSLTSINITSGLIQGNAYTFYVVSYG
 |..|...  ..  .... | ..   .  ||||| | . ...  ........ |.  . .||  |  |.| | .. 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn

fn3 Fibronectin type III domain 293-376 1e-13 44.4 Pfam-A 2-83 (85) alignment
Range on Protein: 293-376
Range on HMM: 2-83/85.0
PVGDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLRGLIPYTNYTVSIIPYNYNMNGP
..... .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|.|| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp

Tmemb_9 TMEM9 380-449 1e-06 15.0 Pfam-A 43-114 (149) alignment
Range on Protein: 380-449
Range on HMM: 43-114/149.0
EIQLTAQSSSLVTVFITVGIIVSSLLIILIIIIISVVVLKKKRFKKNHDLVTRNNLNDK-P-VTAEHNLTTY
| .  ..|.... | | . . . .||.. .. .. .  | .||.|... | | .. .|. | |.|...| . 
eckyeersttiikvviiivlsiigllllymlflllldPllrkrvkaseqlqteeddddarpavaaadsldls

I-set Immunoglobulin I-set domain 481-567 1e-15 49.3 Pfam-A 1-90 (90) alignment
Range on Protein: 481-567
Range on HMM: 1-90/90.0
PVIEEFPNDVTSEEGREVLLKVKFKGTPTPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVNQQVVLTV
|.... ..||. .|| .| |... .|.|.||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_2 Immunoglobulin domain 481-564 1.3e-07 23.5 Pfam-A 2-77 (80) alignment
Range on Protein: 481-564
Range on HMM: 2-77/80.0
PVIEEFPndVTSEEGREVLLKVKFKGTPTPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANNDAGT-VNQQVV
||... |  .. .||  | |  ...| |||.. ||..||...   .        |.. .|.....|||. .| |. |  ... | 
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsve

Ig_3 Immunoglobulin domain 483-554 1.7e-06 20.2 Pfam-A 4-75 (75) alignment
Range on Protein: 483-554
Range on HMM: 4-75/75.0
IE-EFPNDVTSEEGreVLLKVKFKGTP-TPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHKGTYRFVANN
|  .....|||...  | |    .|.| .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
isvspsptvtsggn..vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN

0051299 (Phosphotyrosine protein) phosphatases II 587-810 7.5e-53 175.2 In-house 3-272 (288) alignment
Range on Protein: 587-810
Range on HMM: 3-272/288.0
NLIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH---------------------------------------
. |.||.. ..| . .|.|. |....| .| |   |.| ...| | |.. ||. .|.   |                                       
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

-----FWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVTGEYNITLLNENTNNRYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNP
     ||.|. . ||. ||||... |...| |.||||. .. |. |.. .|||.| ... |. |..||.|.     .| .. ||.|. |||   |   .|
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

QTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0045450 (Phosphotyrosine protein) phosphatases II 588-810 1e-47 158.8 In-house 8-290 (307) alignment
Range on Protein: 588-810
Range on HMM: 8-290/307.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGES--DHTATVGLSPSNKPLNRFANIVVS----------------------------------------
.|.....  .|.  ......|.. .| .| | .    .. ...|.| ||..||. .|.                                          
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

-------------RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNN-NTGAKQSVTQFQITNWDS
              .||.|. . .||.||||... |...| |.||||. .  |. |.. .|||.|.. . |. |..||...  ||    ||.|. |.|  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

TGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
.|  ......| .|||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. 
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 588-645 9.7e-23 75.4 In-house 1-58 (290) alignment
Range on Protein: 588-645
Range on HMM: 1-58/290.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVS
||||..||||||||||||||||||||.|||||||.||.||||..|||.|||||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvy

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 588-645 8.6e-20 65.9 In-house 1-59 (287) alignment
Range on Protein: 588-645
Range on HMM: 1-59/287.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDS-GESDHTATVGLSPSNKPLNRFANIVVS
|||||.||||||.|||||||||.|||..|.. .....  |......||..||...|.| 
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvp

subfamily_PTPRD_pd Subfamily PTPRD 588-644 4.7e-06 20.5 In-house 4-59 (564) alignment
Range on Protein: 588-644
Range on HMM: 4-59/564.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGeSDHTATVGLSPSNKPLNRFANIVV
 |||... |.||. .|...  | ...  ...| . .| ..   | ||. ||.|||| 
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyaniva

0043336 (Phosphotyrosine protein) phosphatases II 589-810 3.6e-46 153.2 In-house 2-263 (278) alignment
Range on Protein: 589-810
Range on HMM: 2-263/278.0
IPVEQFGEFVANGHAKGNEGFRNQFMMLDSGESdHTATVGLSPSNKPLNRFANIVV--------------------------------------------
|.|... ..... ..... .....|  |.|     | ...|.| ||..||. .|.                                             
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPsaSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMI
  .||.|. . .|| ||||... |.... |.||||  .. |. |.. .|||.|.... |. |..||.|. .| .. ||... ..|   |   .....| .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| 
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

0050432 (Phosphotyrosine protein) phosphatases II 590-811 1.8e-52 173.9 In-house 27-286 (308) alignment
Range on Protein: 590-811
Range on HMM: 27-286/308.0
PVEQFGEFVANghAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH-----------------------------------------F
.|... ... .  |... ... .|. | |   ... .|.| | ||..||. .|.   |                                         |
svldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedF

WKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA--SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
|.|. . ||. ||||... ||..| |.||||.   .. |. | . .|||.| ... |. |..|..|...|    ||.|. |||   |   .|. .| ..|
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

EMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||. 
lvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

0039614 (Phosphotyrosine protein) phosphatases II 590-810 4.2e-46 153.1 In-house 15-275 (297) alignment
Range on Protein: 590-810
Range on HMM: 15-275/297.0
PVEQFGEFVANGHAKGNEGFRNQFMMLDSGESDhtATVGLSPSNKPLNRFANIVVSRH------------------------------------------
|.. .  ..   .|... .....|..| |   |   ...|.| ||..||. .|.   |                                          
plsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

----FWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASNalVTGEYNITLLNENTNNRYIERKFEVKNnnTGAKQSVTQFQITNWDSTGEVKNPQTILM
    ||.|. . .||.||||....|...  |.||||. ..  . |.. .|||.. ... |. |..||.|  .|    ||.|| |.|   |   .....| 
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellle

IIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp

0040438 (Phosphotyrosine protein) phosphatases II 592-810 8.1e-50 165.2 In-house 3-262 (317) alignment
Range on Protein: 592-810
Range on HMM: 3-262/317.0
EQFGEFVANGHAKGNEGFRNQFMMLDSGESDhTATVGLSPSNKPLNRFANIVVSR--------------------------------------------H
... ...   ..... .....|..|.|   | | .|.. | ||..||. .|.                                               .
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEE
||.|. . .|| ||||... |...| |.||||.  . |. |.. .|||.| ... .. |..||...... .  ||.|. |.|.  |  ..|...| ..|.
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

MYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
vreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

0047943 (Phosphotyrosine protein) phosphatases II 602-810 3.2e-50 166.5 In-house 7-258 (273) alignment
Range on Protein: 602-810
Range on HMM: 7-258/273.0
HAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH----------------------------------------FWKMIDDRNVTAIV
...|. ... .| .| |   ..| .|.| | || .||. .|.   |                                        ||.|. . ||. ||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLCQENENNQEVCYQYWPSASN--ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNT
||... |...| |.||||.  .   |. |.. .|||.|.|.. |. |..|..|..|| .  ||.|. |.|   |   ... .| .||.. .....  .|.
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

0036941 (Phosphotyrosine protein) phosphatases II 603-810 4.1e-50 166.1 In-house 9-263 (297) alignment
Range on Protein: 603-810
Range on HMM: 9-263/297.0
AKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH----------------------------------------FWKMIDDRNVTAIVM
.... ... .|. |..   . . .|.|.| |...||. .|.   |                                        ||.|. . ||| |||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENT--NNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNT
|... |.. | |.||||.   . |. |.. .|||....  .. |. |..||.....| .  ||.|..|.|.  |   .|...| .||.. . ...  ...
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

SIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
 ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

0046845 (Phosphotyrosine protein) phosphatases II 609-811 2.2e-48 160.4 In-house 2-261 (284) alignment
Range on Protein: 609-811
Range on HMM: 2-261/284.0
FRNQFMMLDSGESDH--TATVGLSPSNKPLNRFANIVVS--------------------------------------------------RHFWKMIDDRN
.. .|..| |   ..  . .|.| | |. .||. .|..                                                    .||.|. . |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-
|. ||||... ||..| |.||||. .. |. |.. .|||.|.... |. |..|..|.. ||    ||.|..|.|   |   .|. .| ..... . ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVV
 |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0045098 (Phosphotyrosine protein) phosphatases II 620-810 9.6e-43 141.9 In-house 20-258 (278) alignment
Range on Protein: 620-810
Range on HMM: 20-258/278.0
ESDHTATVGLSPSNKPLNRFANIVV--------------------------------SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVT
 .  . |..| ..|...||. .|.                                   .||.|. . ..|.||||... |...| |.||||. .. |. 
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggslty

GEYNITLLNENTNNRYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNP--QTILMIIEEMYRTQR------------KRGNTSIVVHCSDTVG
|.. .|||.| ... |. |...| |     ... .  ||......|.  |   .|  . .| ..|.. . ..              ... ..||||  ||
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTV
|.....|| . .  .  ||..|.....|  | |.|| .||. 
RtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl

0049772 (Phosphotyrosine protein) phosphatases II 622-820 6.3e-14 47.9 In-house 35-273 (314) alignment
Range on Protein: 622-820
Range on HMM: 35-273/314.0
DHTATVGLSPSNKPLNRFANIVVSR-------------------------------------------------HFWKMI--DDRNVTAIVM--------
..| .|.  . |.  ||. .|.                                                     .|.|.  .|.||  |||        
eltilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LCQENENNqevcyqywpsasnA-------L--VtgeynitllnentnnryierkfEVKNNNTGAKQSVTQFQITNWDStGEVKNPQT
             |..  .|.             .                                 |. ...   .. . ..  ....  |..  .. 
elsrLdaAlgKtpllildgng.............neptaadlellk......................eelydpelferlgikylripvpD.gsaplled

ILMIIEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDVFQVLKSQRIQKPGSvQTVVSVQLYLPYE
.. ..| . .    . .. ..|||.. .||.. |..||  . ...   . .... ....|  .|    .. . ..|. ..
fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp.gfieqleqyefil

0040439 (Phosphotyrosine protein) phosphatases II 625-810 9.7e-42 138.7 In-house 3-232 (249) alignment
Range on Protein: 625-810
Range on HMM: 3-232/249.0
ATVGLSPSNKPLNRFANIVVS--------------------------------------------RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS
 .|.| | ||..||. .|.                                               .||.|. . ..|.||||... |...| |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

aSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAAT
 .. |. |.. .|||...... |. |..|..|. .| .  |...|.|.|  .|  ......| .||..   ...   .. ..||||. |||...|.|| .
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..  ..|. .|.....|  | |.||.||. 
mleqlekelgvdleeavkllrsqRpgavqnp

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 625-808 7.4e-16 53.0 In-house 21-205 (255) alignment
Range on Protein: 625-808
Range on HMM: 21-205/255.0
ATVGLSPSNKPLNRFANIVVSRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA-LVTGEYNITLLNenTNNRYIERKFEVKNNNT--GAKQSV
 | .. |.... ..  ...   .|...|   . . .||||  .|...| | .|.|   .  |.  . |.|  .  . .  . |  |.  . .     . |
ctehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtv

TQFQITNWDSTGEVKNPQTILMIIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
. .. . |      .... || |.    .  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......
khysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraih

0037934 (Phosphotyrosine protein) phosphatases II 626-810 8.5e-38 125.7 In-house 3-228 (243) alignment
Range on Protein: 626-810
Range on HMM: 3-228/243.0
TVGLSPSNKPLNRFANIVVSRH---------------------------------------FWKMIDDRNVTAIVMLCQENENNQEVCYQYWPsaSNAlV
...|.| |.. ||. .|.   |                                       ||.|. . ..|.||||... |...| |.||||  ..  .
siallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.t

TGEYNITLLNENTNNRYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAA
 |.. .|||.|.. . |. |.....| . .. .. |.... ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....|| 
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

TTINKCkteGvIDVFQVLKSQRIQKPG-SVQTV
. . ..   | .|.....|  | |.|| .||| 
lmllll...g.vdleeavkllreqRpgkavqtp

0042113 (Phosphotyrosine protein) phosphatases II 627-810 1.8e-42 140.8 In-house 3-229 (245) alignment
Range on Protein: 627-810
Range on HMM: 3-229/245.0
VGLSPSNKPLNRFANIVVS--------------------------------------------RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaS
|.| | ||..||. .|.                                               .||.|. . ..|.||||..| |.... |.||||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

NALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
. |..|.. .|||.|.... |. |..||.|. .. .. |.... ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

KCKTEGVIDVFQVLKSQRIQKPGSVQTV
  ..|. .......|  | |.||.||| 
qlekelgvsleeavkelrsqRpgavqtp

0041856 (Phosphotyrosine protein) phosphatases II 633-810 3.3e-20 67.9 In-house 1-157 (182) alignment
Range on Protein: 633-810
Range on HMM: 1-157/182.0
NKPLNRFANIVVS----------------------------------RHFWKMIDDRNVTAIVMLCqenennqevCYQYWPsasnalvtgeynitllnen
|...||. .|.                                     .|..|. ....|.||.|.         ...|||                   
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...................

tnnryierkfevknnnTGAKQSVTQFQITNWDSTGEVKnPQTILMIIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKS
                .  .. ..|.. ..|.  |    ....| .|||...      .  ..||||  |||.....||   . .    | .......| 
................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavkl

QRIQKPGSVQTV
 | ..||.|.| 
vrsrRpgmvitp

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 641-810 1.9e-15 51.2 In-house 97-222 (392) alignment
Range on Protein: 641-810
Range on HMM: 97-222/392.0
NIVVSRHFWKMIDDRNVTAIVMLCQENENNqevcyqywpsasnalvtgeynitllnentnnryierkfevknnNTGAKQSVTQFQITNWDSTGEVKNPQT
|.     ||.|. . |||.|.|. . .| .                                           .   ...|.||..|.|   .  |   .
naaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtss

ILMIIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.| .|.|.   . . |. .  ...|||  |||...  .  . . ..|.  ..|||...   | ..|  ||| 
llkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

0036282 (Phosphotyrosine protein) phosphatases II 644-809 2.3e-26 87.9 In-house 27-155 (174) alignment
Range on Protein: 644-809
Range on HMM: 27-155/174.0
VsrhFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSasnalvtgeynitllnentnnryierkfevknNNTGAKQSVTQFQITNWDSTGEVKNPQtILM
    ||.|. . ..|..|||..|.|.. . |..|||.                                . .  .... |.. ..|.  |.   .. .| 
a...fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.lle

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
fvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 644-810 1.1e-18 62.3 In-house 64-227 (239) alignment
Range on Protein: 644-810
Range on HMM: 64-227/239.0
VSRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVtgEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
 |  ||.|. .     ||||    |  .. |.|||| ...  .  .  .|| . .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 644-810 1.1e-18 62.3 In-house 63-226 (239) alignment
Range on Protein: 644-810
Range on HMM: 63-226/239.0
VSRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVtgEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
 |  ||.|. .     ||||    |  .. |.|||| ...  .  .  .|| . .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 644-741 5.2e-09 30.1 In-house 149-242 (244) alignment
Range on Protein: 644-741
Range on HMM: 149-242/244.0
VSRHFWKMIDDRNVTAIVMLCQENENNQevcyqYWPSaSNALVTGEYNITL-LNENTNNRYI-ERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTI
 |  ||||. .| |  .|.|   .|...     |||  |. |   | .||. | .  . . |   ..|.. .   ..|..| |||.|| | |   |   |
tsmdfwkmmlerhvnvlvvlgsveeede.....ywpd.seplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndhfi





subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 645-810 1.2e-40 134.1 In-house 88-252 (283) alignment
Range on Protein: 645-810
Range on HMM: 88-252/283.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNN-NTGAKQSVTQFQITNWDSTGEVKnPQTILM
 . ||||. |...|||||| .  |.... | ||||.   .   ||. .|| .| |.| .| ... ...|  . ..  .. .|. .| . ||   .   |.
vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslv

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl

subfamily_PTPN3_pd Subfamily PTPN3 645-810 1.2e-31 104.7 In-house 97-261 (280) alignment
Range on Protein: 645-810
Range on HMM: 97-261/280.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMI
. .||.|. ..... |||| .  |. .  |.||||. .. |  ||..... .|.... |. |.. .|...|  .....|.| ..|   |  .... .| .
atdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflef

IEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.
verv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta

subfamily_PTPN1_pd Subfamily PTPN1 645-811 2.5e-28 93.6 In-house 84-258 (290) alignment
Range on Protein: 645-811
Range on HMM: 84-258/290.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN--ALVTG--EYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQT
  |||.|. ...  |.||| .  |..|  |.||||.  .  .|.    .....|..|.... |. |..|..| .|   .....|  | |   |  . |..
vdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa

ILMIIEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .||  
flkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad

subfamily_PTPN14_pd Subfamily PTPN14 645-811 2.6e-22 74.2 In-house 106-283 (300) alignment
Range on Protein: 645-811
Range on HMM: 106-283/300.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA---SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTI
 . ||.|. . .|. |||| .|.|. .| ...|.|.     . .  |....|    .. ...| .....|   .. ...|  .| |.|   |  ..... 
vqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgf

LMIIEEMYRTQRKRGNT--------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|  .||.   .||  ..         ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. 
lsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 645-816 1.8e-21 71.2 In-house 103-271 (301) alignment
Range on Protein: 645-816
Range on HMM: 103-271/301.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENT--NNRYIERKFEVKNNNT-GAKQSVTQFQITNWDSTGEvknPQT
|  || |.   .|  ||||.|. |...|.| .| |.  |. |  | ..|.. |...  |.. ..|..||..     | ..|| .| ..|   |    |..
sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgv...Pks

ILMIIEEMYRTqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVvsVQLY
   . . |     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.   |||
haelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn..sqly

0051082 (Phosphotyrosine protein) phosphatases II 645-814 9.1e-18 59.8 In-house 22-143 (151) alignment
Range on Protein: 645-814
Range on HMM: 22-143/151.0
SRHFWKMIDDRNVTAIVMLCQENENNqeVCYQYWPSASnalvtgeynitllnentnnryierkfevknnntgakQSVTQFQITNWDSTGEVKNPQTILMI
. .|.... . ....||.|..| |..   |..|.|...                                      |....|..|. .|   .....| .
ladflellkelgiktivnlrseeerg..ycpeylpelg....................................ievlhipildwpdpglplsfdavlef

IEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVVSVQ
.|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.    .
lellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

subfamily_hpo-7_pd Subfamily hpo-7 645-808 7.9e-15 49.5 In-house 47-211 (263) alignment
Range on Protein: 645-808
Range on HMM: 47-211/263.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTgEYNITLLNENTNNRYIERKFEVKN--NNTGAKQSVTQFQITNWDSTGEVKNPQTIL
   |...|   . . .||||  ||...| | .|.|   .       |...   .. .  . .  |. .  ..    . |.... . |  . ...... ||
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk.lanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

MIIeemyRTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
 |.    .    |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......
nil....kva..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraih

subfamily_CG42327_pd Subfamily CG42327 645-748 1.4e-11 38.6 In-house 85-190 (319) alignment
Range on Protein: 645-748
Range on HMM: 85-190/319.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA---SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQItNWDSTGEVKNPQTI
|  ||... ...   || |..  |.  .|| .|.|.     |  . |.. .|| . ....||.   . .|. .    . .| .   .|  ..   .....
ssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaal

LMIIEEM
. .. |.
iamllev

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 645-737 9e-09 29.7 In-house 41-129 (130) alignment
Range on Protein: 645-737
Range on HMM: 41-129/130.0
SRHFWKMIDDRNVTAIVMLCQENENNQevcyqYWPSaSNALVTGEYNITL-LNENTNNRYIER-KFEVKNNNTGAKQSVTQFQITNWDSTGEVKN
| .||||. .| |  .|.|   .|...     |||  |. |   | .|.. | .  . ..|.  ..|....   ..|..| |||.|| | |   |
smdfwkmmleryvnvlvvlgsveeede.....ywpd.sePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdgttpn

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 645-810 8.1e-08 26.3 In-house 95-262 (312) alignment
Range on Protein: 645-810
Range on HMM: 95-262/312.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS------NALVTGEYNITL-LNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKN
. |||..      |.|..||   |.  | | .|           .  |  ||   . .  .....   | . |  . || .  . ..| . |   |    
cthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds

PQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVFQVLKSQRIQkpgSVQTV
 .| | ..  .     |. .  .. |||  |||.  ..      ... . . . | |.| .|. .| .   ||...
cdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar...svrvf

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 646-811 7.3e-91 299.1 In-house 100-265 (287) alignment
Range on Protein: 646-811
Range on HMM: 100-265/287.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNaLVTGEYNITLLNENTNNRYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILMI
| |||.|||||||||||||||.||..||||||||. .. .| |||||.||||..|. |||||.||||.| .|.||.|.|.|||||||||.|..|||||..
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 646-818 3.7e-89 293.4 In-house 105-281 (290) alignment
Range on Protein: 646-818
Range on HMM: 105-281/290.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALvTGEYNITLLNENTNNRYIERKFEVKNNNT-GAKQSVTQFQITNWDSTGEVKNPQTILMI
..|||.|....||.||||....|.....|.||||.....   ||..|.||||.| |.|||||.||||.|. ||||||||.|||||||||.|.||||||..
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ----LYLP
|||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||...|    ..| 
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 646-810 4.2e-48 159.1 In-house 103-269 (305) alignment
Range on Protein: 646-810
Range on HMM: 103-269/305.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA-LVTGEYNITLLNENTNNRYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILM
. ||..| .  |. ||||..  |.... |.|||| . .     ||....| .|.| . |||||... . ..   ...|.|.|.|.|   | .. . ..| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| 
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 646-811 4.6e-45 148.6 In-house 99-280 (301) alignment
Range on Protein: 646-811
Range on HMM: 99-280/301.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNEN-----------------TNNRYIERKFEVKNNNtgAKQSVTQFQIT
. ||..| .  ...|||.....|. .. |.||||....     |. ..|| ||.                 .|| ||||||.||...  . ..|.|.|.|
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvt

NWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.|   | |..|.|.|..|...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  
dWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLe

Y_phosphatase Protein-tyrosine phosphatase 646-810 2.3e-43 143.7 Pfam-A 56-223 (235) alignment
Range on Protein: 646-810
Range on HMM: 56-223/235.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWP-SASNALVTGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKNPQTI
 .||.|. ...|..||||....|...| | |||| . .. | .|.....|  .|.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

Y_phosphatase Protein-tyrosine phosphatase 646-810 2.3e-43 143.7 In-house 56-223 (235) alignment
Range on Protein: 646-810
Range on HMM: 56-223/235.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWP-SASNALVTGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKNPQTI
 .||.|. ...|..||||....|...| | |||| . .. | .|.....|  .|.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

DSPc_SM00195 646-810 5e-41 136.1 In-house 83-248 (263) alignment
Range on Protein: 646-810
Range on HMM: 83-248/263.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNN-RYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
..||.|. ...|. ||||..|.||..| |..|||. | .  . |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 646-810 5e-41 136.1 In-house 83-248 (263) alignment
Range on Protein: 646-810
Range on HMM: 83-248/263.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNN-RYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
..||.|. ...|. ||||..|.||..| |..|||. | .  . |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 646-809 3.8e-39 129.6 In-house 103-265 (318) alignment
Range on Protein: 646-809
Range on HMM: 103-265/318.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
. ||.|. ..| . |||| ||.|. .. . .||||   .   |.  ..| .| . . |. |.|.|..... ... | |...|.|  .|  ... ..| ..
eDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 646-810 2.1e-35 117.2 In-house 66-228 (250) alignment
Range on Protein: 646-810
Range on HMM: 66-228/250.0
RHFWKMIDDRNVTAIVMLCQENENNQEvCYQYWPSAsNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 .||.|. ......|||| . .|.... . ||||   .|   |.  ..||....   |. ||. . ...   .. | |.. ..|   |  .. ...| ..
edfWrmvleeksgtivmLtnLkesekt.yhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLell

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
kkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl

subfamily_PTPRB_pd Subfamily PTPRB 646-811 7.4e-33 108.8 In-house 108-272 (293) alignment
Range on Protein: 646-811
Range on HMM: 108-272/293.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNnnTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 .||.|. ......|||| |  |. .. | .|||. ... . |. ..||..|.. . .. |......  . ....|.|.. | |   |  ....|.| ..
ddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

EEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek

subfamily_PTPRK_pd Subfamily PTPRK 646-810 2.9e-32 106.8 In-house 100-263 (314) alignment
Range on Protein: 646-810
Range on HMM: 100-263/314.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNAlvTGEYNITLLNENTNNRYIERKFEVKN--NNTGAKQSVTQFQITNWDSTGEVKNPQTILM
. ||... | | ..|||| .  |. .  |..|||  ..    |. ...|.. .... .. | | |..   .  ... | ||| ..| . .  .. ...| 
kdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

IIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
lvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 646-809 1.1e-31 104.6 In-house 100-261 (515) alignment
Range on Protein: 646-809
Range on HMM: 100-261/515.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS-ASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTgaKQSVTQFQITNWDSTGEVKNPQTILMI
  ||... . |||.|.|. . .|...  | .|||   ....  |.... |.  ..    | ||..|  ..    . ||||. |.|   |  |. ...| .
ddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllkl

IEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||
ikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 646-812 1.1e-27 91.8 In-house 106-267 (315) alignment
Range on Protein: 646-812
Range on HMM: 106-267/315.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAsnALVTGEYNITLLNENTNNRYIERKFEVKNNNtgAKQSVTQFQITNWDsTGEVKNPQTILMII
. ||... . ... |||| .  |.... . .|||     .. |.. .|. .|. |..|  | . |  ..    . | |...| |  . .| .  . || .
kdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswp.dmgvpkytiplmnl

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..  
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq

subfamily_PTPN13_pd Subfamily PTPN13 646-809 5.8e-27 89.6 In-house 91-254 (273) alignment
Range on Protein: 646-809
Range on HMM: 91-254/273.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV--TGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
. ||.|. ..... |.|. .| |...  | .|||.  |  .  .. ....||. .  . .  |...||....|. . |.... ..|   |  .... .| 
kdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq

IIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | |||
fvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt

subfamily_PTPN9_pd Subfamily PTPN9 646-809 8.2e-26 85.7 In-house 99-275 (297) alignment
Range on Protein: 646-809
Range on HMM: 99-275/297.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMI
. ||.|. ...|  |||  .  |. .  | ||||. .. .   |..... .. .... | .|..|.|| .|. ...|| ||.. |   |  .. ...| .
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

IEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 646-815 1.2e-25 85.0 In-house 78-255 (270) alignment
Range on Protein: 646-815
Range on HMM: 78-255/270.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA---LVTGEYNITLLNENTNNRYIERKFEVKnnNTGAKQSVTQFQITNWDSTGEVKNP----
..||.|| ...||||||. . .|.... | .|||. ..    | .|. ... |.|. .. || .. ...  ..| .. .. |. ..|   | ....    
ksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedssl

--QTILMIIEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
  . .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||... ...
stdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyef

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 646-820 1.5e-24 81.3 In-house 94-271 (287) alignment
Range on Protein: 646-820
Range on HMM: 94-271/287.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNE-NTNNRYIERKFEVKNNNTGAKQSVTQFQITNWdsTGEVKNPQ---TI
| ||... .......... .| |. .  ||.|||     .  | | ..||.  . .  |  | . . . .|   . | |... .|    .|  |     |
rdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavgli

LMIIEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYLPYE
 ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.||  || | ||
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv..qlrllye

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 646-810 9.4e-23 75.5 In-house 86-245 (267) alignment
Range on Protein: 646-810
Range on HMM: 86-245/267.0
RHFWKMIDDRNVTAIVMLCQENENNqeVCyQYWPSA-SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKqSVTQFQITNWDSTGEVKNPQTILmi
 .|...| |..|. ||.| .  ..|  .  ..||    .|    .  .    |. .| |    .|.| .|  |.  || .   .|.   . |     |  
tdfltvihdqkvpvivlltkvftdn..ir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkwnintnnkpylkpl..

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk

0051429 (Phosphotyrosine protein) phosphatases II 646-815 1.1e-22 76.5 In-house 36-216 (272) alignment
Range on Protein: 646-815
Range on HMM: 36-216/272.0
RHFWKMiDDRNVTAIVMLCQENENNQEVCYQYWP-----------SASNALVTGEYNITLLNENTNNRYIERKFEVKNN-NTGAKQSVTQFQITNWDSTG
..||..  . ....||.|..|.| ... |..|||           ..      | . .||| | . . || |......  ..|.   |.... |.|   |
adfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

EVKNPqtILMIIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVVSVQL
  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.|||   .. 
vpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

0043147 (Phosphotyrosine protein) phosphatases II 646-821 6e-20 67.1 In-house 34-158 (172) alignment
Range on Protein: 646-821
Range on HMM: 34-158/172.0
RHFWKMIDDRNVTAIVMLCQEnennqevcyqywpsasnalvtgeynitllnentnnryierkfevKNNNTGAKQSVTQFQITNWDSTGEVkNPQTILMII
 .||.|. ....|.||.|...                                             .. .. .... |.. ..|.  |   ... .| ..
adfwrmlkelgithivnltel............................................lydpellerlgiqylylpwpDhgvp.llelllefl

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVVSVQLYLPYED
| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.    .. . .|.
efidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyfek

0046846 (Phosphotyrosine protein) phosphatases II 646-810 3.6e-19 64.6 In-house 37-159 (176) alignment
Range on Protein: 646-810
Range on HMM: 37-159/176.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVtgeynitllnentnnryierkfevknnntgakqsvtQFQITNWDSTGEVKNpQTILMII
 .|..|. . ..||.|.|..| | ..  |..|||   .. .                                    |.. ..|.  |     . .| ..
adflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl.elllell

EEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| 
efirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

0044763 (Phosphotyrosine protein) phosphatases II 646-809 1.3e-17 59.4 In-house 38-156 (178) alignment
Range on Protein: 646-809
Range on HMM: 38-156/178.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNalvtgeynitllnentnnryierkfevknnntgakqsvTQFQITNWDSTGEVKNPQTILMII
 ...... . ..|.||.|..| |.... |..|||.  .                                       |.. ....  |.   .. .| ..
addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhipipDhgvpdllehflefv

EEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
efieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 646-812 1.2e-15 51.7 In-house 105-276 (302) alignment
Range on Protein: 646-812
Range on HMM: 105-276/302.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENTN-NRYIER------KFEVKNNNTG--AKQSVTQFQITNWDSTGEV
  .| .|.. ||. .| ||.  |.... | .|.     . |  |.| .. .. .|. ... ..      . |.||...    |..|  .. . |   |  
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGap

KNPQTILMIIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
|...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.   
keaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 646-811 2e-15 51.2 In-house 105-266 (439) alignment
Range on Protein: 646-811
Range on HMM: 105-266/439.0
RHFWKMIDDRNVTAIVMLCQENEnnqevCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKNNNT--GAKQSVTQFQITNWDSTGEVKNPQTILM
 .||... ..... ||||..  |      |.|||| ... . |.  .    .    .|. | | | |.      ...| ||. . |       .   .| 
ddfwrlviekktvtivmltnlve.....sykywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 646-812 6.6e-15 49.9 In-house 96-265 (307) alignment
Range on Protein: 646-812
Range on HMM: 96-265/307.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNNRYI--ERK-F---EVKNNNTGAKQSVTQFQITNWDSTGevkNP
 .|| |. . .| ...|||.  |  .  | ||||    . || || . |.  .|   . .  . .     ..| . ..  ......| .||   |    |
ysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vp

QTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
|. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| . 
qinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 646-812 7e-13 43.2 In-house 96-259 (288) alignment
Range on Protein: 646-812
Range on HMM: 96-259/288.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTnnRYIERKFE---VKNNNTGAKQS-VTQFQITNWDSTGEVKNPQTI
  .|||. . .|  |||||.  |  .|   .|.||     .    . |   ..     |..  .   ......| ..  | .  . .||  |  .| .. 
eelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsp

LMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
| ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..||   
lrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemq

subfamily_PTPRD_pd Subfamily PTPRD 647-809 2.9e-44 146.7 In-house 106-266 (564) alignment
Range on Protein: 647-809
Range on HMM: 106-266/564.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
 ||.|. ..|.. |||| . .|.... | .|||. .     ||. .|| .|.. . |. |.|..|....  .. |.||. |.| ..|  ......| .|.
dFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

EMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
kvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 647-810 3.4e-40 133.2 In-house 114-276 (298) alignment
Range on Protein: 647-810
Range on HMM: 114-276/298.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
 ||.|. ......|||| . .| ..  . .|||.  ..   || ...||....   .| ||..|.....  ...| |.. |.| . |. .| ...| ...
dFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

EMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| 
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 647-810 6.3e-35 115.7 In-house 106-269 (319) alignment
Range on Protein: 647-810
Range on HMM: 106-269/319.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAsNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA-KQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. ....  .|||.. .|. .  . .|||.. |  . |.. .||..|.  . || ||........     .|..|| |.|   .  .. ...| ..
dfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. 
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp

subfamily_PTPRA_pd Subfamily PTPRA 647-812 1.5e-34 114.3 In-house 116-283 (330) alignment
Range on Protein: 647-812
Range on HMM: 116-283/330.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNPQTIL
 ||.|| ... ..|||| . .| ..| |.||||.   ..  |. .... .|.  . |  ||| |..     .  ... |.||  | |   |   .|. .|
dfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGml

MIIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||   
kllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeq

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 647-814 2.7e-34 113.5 In-house 99-266 (281) alignment
Range on Protein: 647-814
Range on HMM: 99-266/281.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVkNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
.||.|. ...|.||||. .| |...  |..|||  ...|  |.. .. ..|.....||||||.. ....| ...|.|.. |.|  .|  .... .|   .
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrk

EMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSVQ
|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||  .
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqye

subfamily_PTPN12_pd Subfamily PTPN12 647-810 3e-33 110.0 In-house 98-263 (290) alignment
Range on Protein: 647-810
Range on HMM: 98-263/290.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV-TGEYNITLLNENTNN-RYIERKFEVKNNntGAKQSVTQFQITNWDSTGEVKNPQTILMI
 ||.||.. ||. .||.|.| |...  | .|||.  .  . .||...|| .|.. .  .. | ..|...  .....|.||. |.|   |  ......| .
dfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllel

IEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
||.. ..|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| 
ielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk

subfamily_PTPN6_pd Subfamily PTPN6 647-812 1.4e-32 108.0 In-house 113-285 (306) alignment
Range on Protein: 647-812
Range on HMM: 113-285/306.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVK-NNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. . | . |||. .|.| ..| |..|||....   .|....| ..|.....|| |.. |. ... . ...| |.. ..|   |  |.|...|  .
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVS
|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||   
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqq

subfamily_PTPN23_pd Subfamily PTPN23 647-814 6.7e-32 105.4 In-house 98-270 (288) alignment
Range on Protein: 647-814
Range on HMM: 98-270/288.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. .. .  |||| ...| ... . .|||.. . . . |....|| .... . ..||..... ... |..||.  |.|.| . |  . |.|.| ..
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

EE---MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
.|   .|...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..  ..
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 647-809 6.7e-32 105.6 In-house 102-262 (315) alignment
Range on Protein: 647-809
Range on HMM: 102-262/315.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS-ASNALVTGEYNITLLNENTNNRYIERKFEVKNNNtgAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. . .||.|||. . .|...  | ||||   ...   |.....||. ...   . ||. ... .  ... ||||| |.|   |  |.  ..| .|
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllkli

EEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||
kevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

subfamily_Ptp69D_pd Subfamily Ptp69D 647-810 7.1e-32 105.7 In-house 106-272 (307) alignment
Range on Protein: 647-810
Range on HMM: 106-272/307.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAsNALVTGEYNITLLNENTNNRYIERKFEVKNNN-----TGAKQSVTQFQITNWDSTGEVKNPQTI
 ||.|| . .|| |||| ...| |.. | .|||   .    |. ...| .|.. . ||.|...| ...       ... |.|.. |.|. .   . ....
DfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

LMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .||...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  
lklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 647-811 1.6e-31 104.5 In-house 105-266 (288) alignment
Range on Protein: 647-811
Range on HMM: 105-266/288.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKnnNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
.||... ..... |||| .  |.... | .|||.| .    |. ..||..... . ...||....   .. .  .||.| . |  .|  .. . .| ...
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr

EMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||. 
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 647-810 1.2e-30 101.7 In-house 107-270 (297) alignment
Range on Protein: 647-810
Range on HMM: 107-270/297.0
HFWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASNALvTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVK--NPQTILMI
 ||.|. | .|..|||| ..||...  | .||.  . .   |.  ..||  .  . .|.|..||..... |.. | |.| ..| .  . .  . ...| .
dfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllkl

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  ||| 
isevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk

subfamily_PTPRG_pd Subfamily PTPRG 647-809 8.8e-30 98.4 In-house 106-272 (563) alignment
Range on Protein: 647-809
Range on HMM: 106-272/563.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAK------QSVTQFQITNWDSTGEVKNPQT
 ||.|| ..||. |||. . .|.... | .|||.  ...  |. ..|| .|..   | .|.. .|| .  .|      . |.|.. |.|  .|  . .  
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

ILMIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||
vLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 647-811 1e-29 98.7 In-house 106-275 (325) alignment
Range on Protein: 647-811
Range on HMM: 106-275/325.0
HFWKMIDDRNvTAIVMLCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 .|... | . ...|..  | ..... | .|||   ...   |  .. |   ..   |. |...||. . |  .|| |||.  ||  |  | | |.. |.
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

EEM---YRTQR--KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
. .     . .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| 
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 647-810 3.1e-28 93.6 In-house 88-254 (274) alignment
Range on Protein: 647-810
Range on HMM: 88-254/274.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEY---NITLLNENTNNRYIERKFEVKNNNTgaKQSVTQFQITNWDSTGEVKNPQTILM
 ||.||  ..|. |||| . .|.|.. | .|.| | .. ....|   .|.  . ...| |  ||. .|. .   ..||. .  |.|  .   ....|.| 
dfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlld

IIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | ||| 
lvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 647-813 4.3e-28 93.5 In-house 119-280 (319) alignment
Range on Protein: 647-813
Range on HMM: 119-280/319.0
HFWKMIDDRNVTAIVMLCqenennQEVCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|| . |...||.|       .. | ||||   .    ..... .   .  . |. |..|. .  .   ....||| .  |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

EE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 647-813 7e-28 92.9 In-house 83-244 (284) alignment
Range on Protein: 647-813
Range on HMM: 83-244/284.0
HFWKMIDDRNVTAIVMLCqenennQEVCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|| . |...||.|       .. | ||||   .    ..... .   .  . |. |..|. .  .   .....|| .  |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlv

EE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  
kkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_PTPRN_pd Subfamily PTPRN 647-812 2.1e-25 84.0 In-house 115-280 (297) alignment
Range on Protein: 647-812
Range on HMM: 115-280/297.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNAlVTGEYNITLLNENT-NNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
.||.|. .. |. ||.|.. .|.. . |..|||   .. | . |.. |. |    . |. | | .|| .|   ..||||    | ..|   .....|   
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr

EEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
  . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|   
rkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq

subfamily_CG7180_pd Subfamily CG7180 647-810 3e-23 76.9 In-house 100-276 (296) alignment
Range on Protein: 647-810
Range on HMM: 100-276/296.0
HFWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNN-------NTGA---KQSVTQFQITNWDSTGEVK
 ||... |... |.|.|... . ..  . .|||  |     ||  . ...|..      |.| .. .       ...    .  |..||.| |..  .| 
efWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP

NPQTILMIIEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
   . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|
lstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv

0049260 (Phosphotyrosine protein) phosphatases II 647-817 4.4e-21 70.6 In-house 24-143 (152) alignment
Range on Protein: 647-817
Range on HMM: 24-143/152.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWpsasnalvtgeynitllnentnnryierkfevknnntgakqsvtQFQITNWDSTGEVKNPQTILMIIE
.||.|. . ..|.||||... |.. . |.||.                                            |.. ..|.  |  ...| .|....
dfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllflll

EMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVVSVQLYL
 . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..    .. .
fiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 647-809 2.5e-20 67.7 In-house 60-224 (237) alignment
Range on Protein: 647-809
Range on HMM: 60-224/237.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA-KQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. . . . ||||    |.|.. |..||||. .    | . ..|  ..    |  | . . .. |    . . |.|.| |   |  ..  ..| . 
dfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfr

EEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .||
kniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 647-810 2.8e-20 67.1 In-house 109-269 (290) alignment
Range on Protein: 647-810
Range on HMM: 109-269/290.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS-ASNALVTGEYNITLLNENTN-NRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGeVknPQTILMI
 .|.|. . .|.||||||.  |. .  | ||.|  . ..|  ||. ..  .|... .. | . . |.. ..| .  .  ..|  |     |  ... | .
diwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.v..alstlal

IEeMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTV
.  . |. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .|||  
lr.tlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvd

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 647-803 8.6e-17 56.2 In-house 82-238 (290) alignment
Range on Protein: 647-803
Range on HMM: 82-238/290.0
HFWKMIDDRNVTAIVMLCQENENNQE----VCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNtGAKQSVTQFQITNWDSTGEVKNPQTI
.|| |. . .|. .||||. .|....     | .| | . .  |  .  ..   .  ...  ..|. .|| .. . .  ||  .. .|...   ....|.
kfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktl

LMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQK
| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.
lsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 647-812 2.8e-16 54.0 In-house 96-257 (281) alignment
Range on Protein: 647-812
Range on HMM: 96-257/281.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA-LVTGEYNITLLNENTNNRYIERKFEVknNNTGAKQSVTQFQITNWDSTgEVKNPQTILMii
 ||.|| . | ||||||||  | |.| | .|.|  . . |   .. ..  .   |.  .  ....     |  . .|..   .|    .| .   ...  
dfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdw.qvpessevml..

eEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVVS
 .. |  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||.  
.kilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 647-812 1.7e-13 44.9 In-house 111-277 (305) alignment
Range on Protein: 647-812
Range on HMM: 111-277/305.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNeNTNNRYIERKFEVKNN------NTGAKQSVTQFQITNWDSTGEvknPQT
.|| |. ...|  |||||.  |  .  | |||| |    ..    | . |  . .. .||  |..        . . | || ..| |.|   |    |  
efwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivven.vsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppc

ILMIIEEMYRTqRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVS
 |  .| .    |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. | 
kltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 647-811 2.2e-11 38.3 In-house 90-257 (285) alignment
Range on Protein: 647-811
Range on HMM: 90-257/285.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV-TGEYNITLLN--ENTNNRYIERKFEVKNNNTGAKQS--VTQFQITNWDSTGevkNPQTI
 ||.|| . ... ..|||   |   | |  |.|     .|  |.|.||| .  |..    |   . | | .  . .   . . |.  |        |.  
dfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdql...apeda

LMIIeEMYRTQRK--RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
  .| |.|.  .|    .. |.||||  |||.| |     .  .   .  |.......  |  .  .||. .
rpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 647-808 5.8e-11 36.9 In-house 19-187 (198) alignment
Range on Protein: 647-808
Range on HMM: 19-187/198.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA--KQSVTQFQITNWD--STGEVKNPQTI
 ||.|. .     |||. ... |..     |||.. . .   |  ..|     |.  |    . . || |     . ....|.| |   .| .|     .
dfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgf

LMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
..   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
vvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 647-808 6.1e-11 36.9 In-house 20-188 (199) alignment
Range on Protein: 647-808
Range on HMM: 20-188/199.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA--KQSVTQFQITNWD--STGEVKNPQTI
 ||.|. .     |||. ... |..     |||.. . .   |  ..|     |.  |    . . || |     . ....|.| |   .| .|     .
dfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgf

LMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
..   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
vvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis

subfamily_egg_pd Subfamily egg 647-811 1.5e-10 35.3 In-house 98-257 (307) alignment
Range on Protein: 647-811
Range on HMM: 98-257/307.0
HFWKMIDDRNVTAIVMLCQENENnqEVCYQYWPSA-SNALVT--GEYNITLLNENTNNRYIERKFEVKN--NNtGAKQSVTQFQiTNWDSTGEVKNPQTI
 ||.|.   .|  ||||    |.  | |  ||| | |..|||  | ..|. |. . .   . |  ..|    .   .. .  .|  ... ...|  |  .
dfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq.gdvnnssdvysplrv

LmiieemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVV
|       |  |.   . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|.
l.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 647-811 1.5e-09 31.9 In-house 109-277 (310) alignment
Range on Protein: 647-811
Range on HMM: 109-277/310.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIER---KF---EVKNNNTGAKQSVTQFQITNWDSTGEVKNPQT
 ||.|| .    .|..||.  |. .  |  ||||   .   |   .| |.| ...  |      |   .|  ..  |.    . .. .|    .   |. 
dfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde

ILMIIEEMYRTQRKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
    . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| .
kchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtel

subfamily_ptpA1_pd Subfamily ptpA1 647-785 2.1e-09 31.6 In-house 104-257 (418) alignment
Range on Protein: 647-785
Range on HMM: 104-257/418.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS----------NALVTGEYNITLLNEN--TNNRYIERkfEVKNNNTGAKQSVTQFQITNWDSTGE
 ||.|. .  .  |||| .|.|| .  | .|||                | | |.. |..     .   | |  ...    |  . .||.|   |     
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfegetrditqyqyegwpdhni

VKNPQTILMIIEEMYRTQRK-----RGNTSIVVHCSDTVGRSAMFCAAATTINKCK
    | .  ..  .   | .       |  |.||||  |||.  ||.|   ..|  
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 647-810 9.6e-09 29.1 In-house 108-271 (302) alignment
Range on Protein: 647-810
Range on HMM: 108-271/302.0
HFWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASNALVtgEYNITLLNENTNNRYIERK----FEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTIL
.||.|. ..... .|.| .|.| ..    ...|  |.. .  ||.   .|    ..  | |     ||  ..      ..   .||| ..   ..  .. 
eFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk..eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli

MIIEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  .....  .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|...
ktaakvfa.kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 647-809 1.3e-08 29.0 In-house 103-272 (305) alignment
Range on Protein: 647-809
Range on HMM: 103-272/305.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV---TGEYNITLLNENTNNRYIERKFEVKNNN--------TGAKQSVTQFQITNWDSTGev
 || |  . .| || |||.  |   . |..|..|  .  .    ..  |..  | ...  .... . | ..         . .. ||..   .|   |  
dfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg..

kNPQTILMIIEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQT
  | . | |.| . ...  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.||
.vpaadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqt

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 647-701 9.8e-08 26.2 In-house 91-146 (297) alignment
Range on Protein: 647-701
Range on HMM: 91-146/297.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNN
 ||... ...| .|||... .|. .. |. ||||.  . | .|.. .  | . ...
dfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 647-713 8.6e-07 23.0 In-house 119-185 (350) alignment
Range on Protein: 647-713
Range on HMM: 119-185/350.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNN
 |.|.|   .|. |..| .. |.| | ||.||.  |   .|   . .  |    |    . ..||..
dfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkke

subfamily_eak_pd Subfamily eak 647-734 9.4e-07 22.5 In-house 108-194 (332) alignment
Range on Protein: 647-734
Range on HMM: 108-194/332.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNNRYIERKFEVKNNNTGakQSVTQFQITNWDSTGE
 ||.|. ...  |||.| .. |.. |   .|.|  . . |  | ....  .   .| .  |..|..  |      |  ...  |  |  
afwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 647-729 1.4e-06 22.0 In-house 251-328 (440) alignment
Range on Protein: 647-729
Range on HMM: 251-328/440.0
HFWKMIDDRNVTAIVMLCQENennQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTgaKQSVTQFQITNW
 ||... | ....|.|| | |   .  |  |||  . ..  | . .     .  ||   | .|.| ..    . . ||..  |
dfwrlvhdyristiimlnqln...dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee..vheirqfevqtw

0048179 (Phosphotyrosine protein) phosphatases II 670-811 6.2e-12 41.0 In-house 43-132 (144) alignment
Range on Protein: 670-811
Range on HMM: 43-132/144.0
NQEVCYqywpsasnalvtgeynitllnentnnryierkfevknnntgakqsVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkrGNTSIVVHCSDTVG
. . ..                                             ..|.. ..|.  |    .. .| ..| . . ..   .  ..||||  ||
eflere.............................................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvg

RSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVV
|.....||   .    ..| ......|.  | . ||.|..  
Rtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg

Filo_glycop Filovirus glycoprotein 695-762 4.5e-06 13.5 Pfam-A 191-260 (364) alignment
Range on Protein: 695-762
Range on HMM: 191-260/364.0
LNENTNNRYIERKFEVKNNNTGAKQSVTQFQI--TNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVV
 .|.. ..|.  . | . ...|...| . |..  |..    . . ||... . |....|...   |  ..
mtedstskYatstleyevedfGteeseiLfevdnttyvqlersltPqfLvqlnetikltnkrsnttgkli

0048076 (Phosphotyrosine protein) phosphatases II 697-810 6.1e-12 40.9 In-house 23-129 (145) alignment
Range on Protein: 697-810
Range on HMM: 23-129/145.0
ENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVL
|.  .  | . . . .. .. .. ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|
ellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KSQRIQKPGSVQTV
.  | | ||.|...
elvrsqrpgavpnp

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 703-779 5.5e-07 23.6 In-house 200-284 (350) alignment
Range on Protein: 703-779
Range on HMM: 200-284/350.0
YIERKFEVKNNNTGAKQsVTQFQITNWDSTGEVKNPQTILMIIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAAT
  .   ...   .     | |.|. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....   
dnnsltaitlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDs

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 719-810 6.4e-11 36.2 In-house 89-180 (440) alignment
Range on Protein: 719-810
Range on HMM: 89-180/440.0
QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... |..   |   |  |    .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

PTPc_DSPc_SM00012 721-810 6.6e-19 63.4 In-house 2-93 (105) alignment
Range on Protein: 721-810
Range on HMM: 2-93/105.0
VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 746-814 3e-06 21.3 In-house 218-285 (297) alignment
Range on Protein: 746-814
Range on HMM: 218-285/297.0
EEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
 | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.   .
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe