Gene PTPRD-26 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP080_AA protein Get Run
AqueP080_AA_591-821 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 105-177 1.9e-06 21.1 Pfam-A 2-77 (85) alignment 
Range on Protein: 105-177
Range on HMM: 2-77/85.0
TPTGLTATRLNTGVAHVRLSWST--VSGATGYEVYYYQLSSNT-PVSVSNTSLTSINITSGLIQGNAYTFYVVSYG
 |..|...  ..  .... | ..   .  ||||| | . ...  ........ |.  . .||  |  |.| | .. 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn
fn3 Fibronectin type III domain 293-376 1e-13 44.4 Pfam-A 2-83 (85) alignment 
Range on Protein: 293-376
Range on HMM: 2-83/85.0
PVGDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLRGLIPYTNYTVSIIPYNYNMNGP
..... .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|.|| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
Tmemb_9 TMEM9 380-449 1e-06 15.0 Pfam-A 43-114 (149) alignment 
Range on Protein: 380-449
Range on HMM: 43-114/149.0
EIQLTAQSSSLVTVFITVGIIVSSLLIILIIIIISVVVLKKKRFKKNHDLVTRNNLNDK-P-VTAEHNLTTY
| .  ..|.... | | . . . .||.. .. .. .  | .||.|... | | .. .|. | |.|...| . 
eckyeersttiikvviiivlsiigllllymlflllldPllrkrvkaseqlqteeddddarpavaaadsldls
I-set Immunoglobulin I-set domain 481-567 1e-15 49.3 Pfam-A 1-90 (90) alignment 
Range on Protein: 481-567
Range on HMM: 1-90/90.0
PVIEEFPNDVTSEEGREVLLKVKFKGTPTPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVNQQVVLTV
|.... ..||. .|| .| |... .|.|.||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
Ig_2 Immunoglobulin domain 481-564 1.3e-07 23.5 Pfam-A 2-77 (80) alignment 
Range on Protein: 481-564
Range on HMM: 2-77/80.0
PVIEEFPndVTSEEGREVLLKVKFKGTPTPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANNDAGT-VNQQVV
||... |  .. .||  | |  ...| |||.. ||..||...   .        |.. .|.....|||. .| |. |  ... | 
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsve
Ig_3 Immunoglobulin domain 483-554 1.7e-06 20.2 Pfam-A 4-75 (75) alignment 
Range on Protein: 483-554
Range on HMM: 4-75/75.0
IE-EFPNDVTSEEGreVLLKVKFKGTP-TPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHKGTYRFVANN
|  .....|||...  | |    .|.| .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
isvspsptvtsggn..vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
0051299 (Phosphotyrosine protein) phosphatases II 587-810 7.5e-53 175.2 In-house 3-272 (288) alignment 
Range on Protein: 587-810
Range on HMM: 3-272/288.0
NLIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH---------------------------------------
. |.||.. ..| . .|.|. |....| .| |   |.| ...| | |.. ||. .|.   |                                       
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

-----FWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVTGEYNITLLNENTNNRYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNP
     ||.|. . ||. ||||... |...| |.||||. .. |. |.. .|||.| ... |. |..||.|.     .| .. ||.|. |||   |   .|
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

QTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0045450 (Phosphotyrosine protein) phosphatases II 588-810 1e-47 158.8 In-house 8-290 (307) alignment 
Range on Protein: 588-810
Range on HMM: 8-290/307.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGES--DHTATVGLSPSNKPLNRFANIVVS----------------------------------------
.|.....  .|.  ......|.. .| .| | .    .. ...|.| ||..||. .|.                                          
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

-------------RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNN-NTGAKQSVTQFQITNWDS
              .||.|. . .||.||||... |...| |.||||. .  |. |.. .|||.|.. . |. |..||...  ||    ||.|. |.|  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

TGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
.|  ......| .|||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. 
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 588-645 9.7e-23 75.4 In-house 1-58 (290) alignment 
Range on Protein: 588-645
Range on HMM: 1-58/290.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVS
||||..||||||||||||||||||||.|||||||.||.||||..|||.|||||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 588-645 8.6e-20 65.9 In-house 1-59 (287) alignment 
Range on Protein: 588-645
Range on HMM: 1-59/287.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDS-GESDHTATVGLSPSNKPLNRFANIVVS
|||||.||||||.|||||||||.|||..|.. .....  |......||..||...|.| 
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvp
subfamily_PTPRD_pd Subfamily PTPRD 588-644 4.7e-06 20.5 In-house 4-59 (564) alignment 
Range on Protein: 588-644
Range on HMM: 4-59/564.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDSGeSDHTATVGLSPSNKPLNRFANIVV
 |||... |.||. .|...  | ...  ...| . .| ..   | ||. ||.|||| 
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyaniva
0043336 (Phosphotyrosine protein) phosphatases II 589-810 3.6e-46 153.2 In-house 2-263 (278) alignment 
Range on Protein: 589-810
Range on HMM: 2-263/278.0
IPVEQFGEFVANGHAKGNEGFRNQFMMLDSGESdHTATVGLSPSNKPLNRFANIVV--------------------------------------------
|.|... ..... ..... .....|  |.|     | ...|.| ||..||. .|.                                             
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPsaSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMI
  .||.|. . .|| ||||... |.... |.||||  .. |. |.. .|||.|.... |. |..||.|. .| .. ||... ..|   |   .....| .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| 
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
0050432 (Phosphotyrosine protein) phosphatases II 590-811 1.8e-52 173.9 In-house 27-286 (308) alignment 
Range on Protein: 590-811
Range on HMM: 27-286/308.0
PVEQFGEFVANghAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH-----------------------------------------F
.|... ... .  |... ... .|. | |   ... .|.| | ||..||. .|.   |                                         |
svldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedF

WKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA--SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
|.|. . ||. ||||... ||..| |.||||.   .. |. | . .|||.| ... |. |..|..|...|    ||.|. |||   |   .|. .| ..|
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

EMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||. 
lvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0039614 (Phosphotyrosine protein) phosphatases II 590-810 4.2e-46 153.1 In-house 15-275 (297) alignment 
Range on Protein: 590-810
Range on HMM: 15-275/297.0
PVEQFGEFVANGHAKGNEGFRNQFMMLDSGESDhtATVGLSPSNKPLNRFANIVVSRH------------------------------------------
|.. .  ..   .|... .....|..| |   |   ...|.| ||..||. .|.   |                                          
plsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

----FWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASNalVTGEYNITLLNENTNNRYIERKFEVKNnnTGAKQSVTQFQITNWDSTGEVKNPQTILM
    ||.|. . .||.||||....|...  |.||||. ..  . |.. .|||.. ... |. |..||.|  .|    ||.|| |.|   |   .....| 
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellle

IIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0040438 (Phosphotyrosine protein) phosphatases II 592-810 8.1e-50 165.2 In-house 3-262 (317) alignment 
Range on Protein: 592-810
Range on HMM: 3-262/317.0
EQFGEFVANGHAKGNEGFRNQFMMLDSGESDhTATVGLSPSNKPLNRFANIVVSR--------------------------------------------H
... ...   ..... .....|..|.|   | | .|.. | ||..||. .|.                                               .
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEE
||.|. . .|| ||||... |...| |.||||.  . |. |.. .|||.| ... .. |..||...... .  ||.|. |.|.  |  ..|...| ..|.
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

MYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
vreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp
0047943 (Phosphotyrosine protein) phosphatases II 602-810 3.2e-50 166.5 In-house 7-258 (273) alignment 
Range on Protein: 602-810
Range on HMM: 7-258/273.0
HAKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH----------------------------------------FWKMIDDRNVTAIV
...|. ... .| .| |   ..| .|.| | || .||. .|.   |                                        ||.|. . ||. ||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLCQENENNQEVCYQYWPSASN--ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNT
||... |...| |.||||.  .   |. |.. .|||.|.|.. |. |..|..|..|| .  ||.|. |.|   |   ... .| .||.. .....  .|.
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 603-810 4.1e-50 166.1 In-house 9-263 (297) alignment 
Range on Protein: 603-810
Range on HMM: 9-263/297.0
AKGNEGFRNQFMMLDSGESDHTATVGLSPSNKPLNRFANIVVSRH----------------------------------------FWKMIDDRNVTAIVM
.... ... .|. |..   . . .|.|.| |...||. .|.   |                                        ||.|. . ||| |||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENT--NNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNT
|... |.. | |.||||.   . |. |.. .|||....  .. |. |..||.....| .  ||.|..|.|.  |   .|...| .||.. . ...  ...
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

SIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
 ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0046845 (Phosphotyrosine protein) phosphatases II 609-811 2.2e-48 160.4 In-house 2-261 (284) alignment 
Range on Protein: 609-811
Range on HMM: 2-261/284.0
FRNQFMMLDSGESDH--TATVGLSPSNKPLNRFANIVVS--------------------------------------------------RHFWKMIDDRN
.. .|..| |   ..  . .|.| | |. .||. .|..                                                    .||.|. . |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-
|. ||||... ||..| |.||||. .. |. |.. .|||.|.... |. |..|..|.. ||    ||.|..|.|   |   .|. .| ..... . ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVV
 |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0045098 (Phosphotyrosine protein) phosphatases II 620-810 9.6e-43 141.9 In-house 20-258 (278) alignment 
Range on Protein: 620-810
Range on HMM: 20-258/278.0
ESDHTATVGLSPSNKPLNRFANIVV--------------------------------SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVT
 .  . |..| ..|...||. .|.                                   .||.|. . ..|.||||... |...| |.||||. .. |. 
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggslty

GEYNITLLNENTNNRYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNP--QTILMIIEEMYRTQR------------KRGNTSIVVHCSDTVG
|.. .|||.| ... |. |...| |     ... .  ||......|.  |   .|  . .| ..|.. . ..              ... ..||||  ||
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTV
|.....|| . .  .  ||..|.....|  | |.|| .||. 
RtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl
0049772 (Phosphotyrosine protein) phosphatases II 622-820 6.3e-14 47.9 In-house 35-273 (314) alignment 
Range on Protein: 622-820
Range on HMM: 35-273/314.0
DHTATVGLSPSNKPLNRFANIVVSR-------------------------------------------------HFWKMI--DDRNVTAIVM--------
..| .|.  . |.  ||. .|.                                                     .|.|.  .|.||  |||        
eltilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LCQENENNqevcyqywpsasnA-------L--VtgeynitllnentnnryierkfEVKNNNTGAKQSVTQFQITNWDStGEVKNPQT
             |..  .|.             .                                 |. ...   .. . ..  ....  |..  .. 
elsrLdaAlgKtpllildgng.............neptaadlellk......................eelydpelferlgikylripvpD.gsaplled

ILMIIEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDVFQVLKSQRIQKPGSvQTVVSVQLYLPYE
.. ..| . .    . .. ..|||.. .||.. |..||  . ...   . .... ....|  .|    .. . ..|. ..
fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp.gfieqleqyefil
0040439 (Phosphotyrosine protein) phosphatases II 625-810 9.7e-42 138.7 In-house 3-232 (249) alignment 
Range on Protein: 625-810
Range on HMM: 3-232/249.0
ATVGLSPSNKPLNRFANIVVS--------------------------------------------RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS
 .|.| | ||..||. .|.                                               .||.|. . ..|.||||... |...| |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

aSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAAT
 .. |. |.. .|||...... |. |..|..|. .| .  |...|.|.|  .|  ......| .||..   ...   .. ..||||. |||...|.|| .
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..  ..|. .|.....|  | |.||.||. 
mleqlekelgvdleeavkllrsqRpgavqnp
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 625-808 7.4e-16 53.0 In-house 21-205 (255) alignment 
Range on Protein: 625-808
Range on HMM: 21-205/255.0
ATVGLSPSNKPLNRFANIVVSRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA-LVTGEYNITLLNenTNNRYIERKFEVKNNNT--GAKQSV
 | .. |.... ..  ...   .|...|   . . .||||  .|...| | .|.|   .  |.  . |.|  .  . .  . |  |.  . .     . |
ctehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtv

TQFQITNWDSTGEVKNPQTILMIIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
. .. . |      .... || |.    .  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......
khysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraih
0037934 (Phosphotyrosine protein) phosphatases II 626-810 8.5e-38 125.7 In-house 3-228 (243) alignment 
Range on Protein: 626-810
Range on HMM: 3-228/243.0
TVGLSPSNKPLNRFANIVVSRH---------------------------------------FWKMIDDRNVTAIVMLCQENENNQEVCYQYWPsaSNAlV
...|.| |.. ||. .|.   |                                       ||.|. . ..|.||||... |...| |.||||  ..  .
siallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.t

TGEYNITLLNENTNNRYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAA
 |.. .|||.|.. . |. |.....| . .. .. |.... ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....|| 
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

TTINKCkteGvIDVFQVLKSQRIQKPG-SVQTV
. . ..   | .|.....|  | |.|| .||| 
lmllll...g.vdleeavkllreqRpgkavqtp
0042113 (Phosphotyrosine protein) phosphatases II 627-810 1.8e-42 140.8 In-house 3-229 (245) alignment 
Range on Protein: 627-810
Range on HMM: 3-229/245.0
VGLSPSNKPLNRFANIVVS--------------------------------------------RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaS
|.| | ||..||. .|.                                               .||.|. . ..|.||||..| |.... |.||||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

NALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
. |..|.. .|||.|.... |. |..||.|. .. .. |.... ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

KCKTEGVIDVFQVLKSQRIQKPGSVQTV
  ..|. .......|  | |.||.||| 
qlekelgvsleeavkelrsqRpgavqtp
0041856 (Phosphotyrosine protein) phosphatases II 633-810 3.3e-20 67.9 In-house 1-157 (182) alignment 
Range on Protein: 633-810
Range on HMM: 1-157/182.0
NKPLNRFANIVVS----------------------------------RHFWKMIDDRNVTAIVMLCqenennqevCYQYWPsasnalvtgeynitllnen
|...||. .|.                                     .|..|. ....|.||.|.         ...|||                   
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...................

tnnryierkfevknnnTGAKQSVTQFQITNWDSTGEVKnPQTILMIIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKS
                .  .. ..|.. ..|.  |    ....| .|||...      .  ..||||  |||.....||   . .    | .......| 
................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavkl

QRIQKPGSVQTV
 | ..||.|.| 
vrsrRpgmvitp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 641-810 1.9e-15 51.2 In-house 97-222 (392) alignment 
Range on Protein: 641-810
Range on HMM: 97-222/392.0
NIVVSRHFWKMIDDRNVTAIVMLCQENENNqevcyqywpsasnalvtgeynitllnentnnryierkfevknnNTGAKQSVTQFQITNWDSTGEVKNPQT
|.     ||.|. . |||.|.|. . .| .                                           .   ...|.||..|.|   .  |   .
naaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtss

ILMIIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.| .|.|.   . . |. .  ...|||  |||...  .  . . ..|.  ..|||...   | ..|  ||| 
llkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk
0036282 (Phosphotyrosine protein) phosphatases II 644-809 2.3e-26 87.9 In-house 27-155 (174) alignment 
Range on Protein: 644-809
Range on HMM: 27-155/174.0
VsrhFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSasnalvtgeynitllnentnnryierkfevknNNTGAKQSVTQFQITNWDSTGEVKNPQtILM
    ||.|. . ..|..|||..|.|.. . |..|||.                                . .  .... |.. ..|.  |.   .. .| 
a...fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.lle

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
fvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 644-810 1.1e-18 62.3 In-house 64-227 (239) alignment 
Range on Protein: 644-810
Range on HMM: 64-227/239.0
VSRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVtgEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
 |  ||.|. .     ||||    |  .. |.|||| ...  .  .  .|| . .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 644-810 1.1e-18 62.3 In-house 63-226 (239) alignment 
Range on Protein: 644-810
Range on HMM: 63-226/239.0
VSRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVtgEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
 |  ||.|. .     ||||    |  .. |.|||| ...  .  .  .|| . .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 644-741 5.2e-09 30.1 In-house 149-242 (244) alignment 
Range on Protein: 644-741
Range on HMM: 149-242/244.0
VSRHFWKMIDDRNVTAIVMLCQENENNQevcyqYWPSaSNALVTGEYNITL-LNENTNNRYI-ERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTI
 |  ||||. .| |  .|.|   .|...     |||  |. |   | .||. | .  . . |   ..|.. .   ..|..| |||.|| | |   |   |
tsmdfwkmmlerhvnvlvvlgsveeede.....ywpd.seplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndhfi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 645-810 1.2e-40 134.1 In-house 88-252 (283) alignment 
Range on Protein: 645-810
Range on HMM: 88-252/283.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNN-NTGAKQSVTQFQITNWDSTGEVKnPQTILM
 . ||||. |...|||||| .  |.... | ||||.   .   ||. .|| .| |.| .| ... ...|  . ..  .. .|. .| . ||   .   |.
vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslv

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl
subfamily_PTPN3_pd Subfamily PTPN3 645-810 1.2e-31 104.7 In-house 97-261 (280) alignment 
Range on Protein: 645-810
Range on HMM: 97-261/280.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMI
. .||.|. ..... |||| .  |. .  |.||||. .. |  ||..... .|.... |. |.. .|...|  .....|.| ..|   |  .... .| .
atdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflef

IEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.
verv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta
subfamily_PTPN1_pd Subfamily PTPN1 645-811 2.5e-28 93.6 In-house 84-258 (290) alignment 
Range on Protein: 645-811
Range on HMM: 84-258/290.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN--ALVTG--EYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQT
  |||.|. ...  |.||| .  |..|  |.||||.  .  .|.    .....|..|.... |. |..|..| .|   .....|  | |   |  . |..
vdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa

ILMIIEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .||  
flkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad
subfamily_PTPN14_pd Subfamily PTPN14 645-811 2.6e-22 74.2 In-house 106-283 (300) alignment 
Range on Protein: 645-811
Range on HMM: 106-283/300.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA---SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTI
 . ||.|. . .|. |||| .|.|. .| ...|.|.     . .  |....|    .. ...| .....|   .. ...|  .| |.|   |  ..... 
vqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgf

LMIIEEMYRTQRKRGNT--------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|  .||.   .||  ..         ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. 
lsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 645-816 1.8e-21 71.2 In-house 103-271 (301) alignment 
Range on Protein: 645-816
Range on HMM: 103-271/301.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENT--NNRYIERKFEVKNNNT-GAKQSVTQFQITNWDSTGEvknPQT
|  || |.   .|  ||||.|. |...|.| .| |.  |. |  | ..|.. |...  |.. ..|..||..     | ..|| .| ..|   |    |..
sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgv...Pks

ILMIIEEMYRTqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVvsVQLY
   . . |     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.   |||
haelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn..sqly
0051082 (Phosphotyrosine protein) phosphatases II 645-814 9.1e-18 59.8 In-house 22-143 (151) alignment 
Range on Protein: 645-814
Range on HMM: 22-143/151.0
SRHFWKMIDDRNVTAIVMLCQENENNqeVCYQYWPSASnalvtgeynitllnentnnryierkfevknnntgakQSVTQFQITNWDSTGEVKNPQTILMI
. .|.... . ....||.|..| |..   |..|.|...                                      |....|..|. .|   .....| .
ladflellkelgiktivnlrseeerg..ycpeylpelg....................................ievlhipildwpdpglplsfdavlef

IEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVVSVQ
.|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.    .
lellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl
subfamily_hpo-7_pd Subfamily hpo-7 645-808 7.9e-15 49.5 In-house 47-211 (263) alignment 
Range on Protein: 645-808
Range on HMM: 47-211/263.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTgEYNITLLNENTNNRYIERKFEVKN--NNTGAKQSVTQFQITNWDSTGEVKNPQTIL
   |...|   . . .||||  ||...| | .|.|   .       |...   .. .  . .  |. .  ..    . |.... . |  . ...... ||
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk.lanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

MIIeemyRTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
 |.    .    |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......
nil....kva..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraih
subfamily_CG42327_pd Subfamily CG42327 645-748 1.4e-11 38.6 In-house 85-190 (319) alignment 
Range on Protein: 645-748
Range on HMM: 85-190/319.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA---SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQItNWDSTGEVKNPQTI
|  ||... ...   || |..  |.  .|| .|.|.     |  . |.. .|| . ....||.   . .|. .    . .| .   .|  ..   .....
ssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaal

LMIIEEM
. .. |.
iamllev
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 645-737 9e-09 29.7 In-house 41-129 (130) alignment 
Range on Protein: 645-737
Range on HMM: 41-129/130.0
SRHFWKMIDDRNVTAIVMLCQENENNQevcyqYWPSaSNALVTGEYNITL-LNENTNNRYIER-KFEVKNNNTGAKQSVTQFQITNWDSTGEVKN
| .||||. .| |  .|.|   .|...     |||  |. |   | .|.. | .  . ..|.  ..|....   ..|..| |||.|| | |   |
smdfwkmmleryvnvlvvlgsveeede.....ywpd.sePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdgttpn
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 645-810 8.1e-08 26.3 In-house 95-262 (312) alignment 
Range on Protein: 645-810
Range on HMM: 95-262/312.0
SRHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS------NALVTGEYNITL-LNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKN
. |||..      |.|..||   |.  | | .|           .  |  ||   . .  .....   | . |  . || .  . ..| . |   |    
cthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds

PQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVFQVLKSQRIQkpgSVQTV
 .| | ..  .     |. .  .. |||  |||.  ..      ... . . . | |.| .|. .| .   ||...
cdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar...svrvf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 646-811 7.3e-91 299.1 In-house 100-265 (287) alignment 
Range on Protein: 646-811
Range on HMM: 100-265/287.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNaLVTGEYNITLLNENTNNRYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILMI
| |||.|||||||||||||||.||..||||||||. .. .| |||||.||||..|. |||||.||||.| .|.||.|.|.|||||||||.|..|||||..
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 646-818 3.7e-89 293.4 In-house 105-281 (290) alignment 
Range on Protein: 646-818
Range on HMM: 105-281/290.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALvTGEYNITLLNENTNNRYIERKFEVKNNNT-GAKQSVTQFQITNWDSTGEVKNPQTILMI
..|||.|....||.||||....|.....|.||||.....   ||..|.||||.| |.|||||.||||.|. ||||||||.|||||||||.|.||||||..
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ----LYLP
|||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||...|    ..| 
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 646-810 4.2e-48 159.1 In-house 103-269 (305) alignment 
Range on Protein: 646-810
Range on HMM: 103-269/305.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA-LVTGEYNITLLNENTNNRYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILM
. ||..| .  |. ||||..  |.... |.|||| . .     ||....| .|.| . |||||... . ..   ...|.|.|.|.|   | .. . ..| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| 
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 646-811 4.6e-45 148.6 In-house 99-280 (301) alignment 
Range on Protein: 646-811
Range on HMM: 99-280/301.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNEN-----------------TNNRYIERKFEVKNNNtgAKQSVTQFQIT
. ||..| .  ...|||.....|. .. |.||||....     |. ..|| ||.                 .|| ||||||.||...  . ..|.|.|.|
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvt

NWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.|   | |..|.|.|..|...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  
dWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLe
Y_phosphatase Protein-tyrosine phosphatase 646-810 2.3e-43 143.7 Pfam-A 56-223 (235) alignment 
Range on Protein: 646-810
Range on HMM: 56-223/235.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWP-SASNALVTGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKNPQTI
 .||.|. ...|..||||....|...| | |||| . .. | .|.....|  .|.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 646-810 2.3e-43 143.7 In-house 56-223 (235) alignment 
Range on Protein: 646-810
Range on HMM: 56-223/235.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWP-SASNALVTGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKNPQTI
 .||.|. ...|..||||....|...| | |||| . .. | .|.....|  .|.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
DSPc_SM00195 646-810 5e-41 136.1 In-house 83-248 (263) alignment 
Range on Protein: 646-810
Range on HMM: 83-248/263.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNN-RYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
..||.|. ...|. ||||..|.||..| |..|||. | .  . |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 646-810 5e-41 136.1 In-house 83-248 (263) alignment 
Range on Protein: 646-810
Range on HMM: 83-248/263.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNN-RYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
..||.|. ...|. ||||..|.||..| |..|||. | .  . |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 646-809 3.8e-39 129.6 In-house 103-265 (318) alignment 
Range on Protein: 646-809
Range on HMM: 103-265/318.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
. ||.|. ..| . |||| ||.|. .. . .||||   .   |.  ..| .| . . |. |.|.|..... ... | |...|.|  .|  ... ..| ..
eDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 646-810 2.1e-35 117.2 In-house 66-228 (250) alignment 
Range on Protein: 646-810
Range on HMM: 66-228/250.0
RHFWKMIDDRNVTAIVMLCQENENNQEvCYQYWPSAsNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 .||.|. ......|||| . .|.... . ||||   .|   |.  ..||....   |. ||. . ...   .. | |.. ..|   |  .. ...| ..
edfWrmvleeksgtivmLtnLkesekt.yhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLell

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
kkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl
subfamily_PTPRB_pd Subfamily PTPRB 646-811 7.4e-33 108.8 In-house 108-272 (293) alignment 
Range on Protein: 646-811
Range on HMM: 108-272/293.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNnnTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 .||.|. ......|||| |  |. .. | .|||. ... . |. ..||..|.. . .. |......  . ....|.|.. | |   |  ....|.| ..
ddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

EEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek
subfamily_PTPRK_pd Subfamily PTPRK 646-810 2.9e-32 106.8 In-house 100-263 (314) alignment 
Range on Protein: 646-810
Range on HMM: 100-263/314.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNAlvTGEYNITLLNENTNNRYIERKFEVKN--NNTGAKQSVTQFQITNWDSTGEVKNPQTILM
. ||... | | ..|||| .  |. .  |..|||  ..    |. ...|.. .... .. | | |..   .  ... | ||| ..| . .  .. ...| 
kdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

IIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
lvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 646-809 1.1e-31 104.6 In-house 100-261 (515) alignment 
Range on Protein: 646-809
Range on HMM: 100-261/515.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS-ASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTgaKQSVTQFQITNWDSTGEVKNPQTILMI
  ||... . |||.|.|. . .|...  | .|||   ....  |.... |.  ..    | ||..|  ..    . ||||. |.|   |  |. ...| .
ddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllkl

IEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||
ikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 646-812 1.1e-27 91.8 In-house 106-267 (315) alignment 
Range on Protein: 646-812
Range on HMM: 106-267/315.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAsnALVTGEYNITLLNENTNNRYIERKFEVKNNNtgAKQSVTQFQITNWDsTGEVKNPQTILMII
. ||... . ... |||| .  |.... . .|||     .. |.. .|. .|. |..|  | . |  ..    . | |...| |  . .| .  . || .
kdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswp.dmgvpkytiplmnl

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..  
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq
subfamily_PTPN13_pd Subfamily PTPN13 646-809 5.8e-27 89.6 In-house 91-254 (273) alignment 
Range on Protein: 646-809
Range on HMM: 91-254/273.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV--TGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILM
. ||.|. ..... |.|. .| |...  | .|||.  |  .  .. ....||. .  . .  |...||....|. . |.... ..|   |  .... .| 
kdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq

IIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | |||
fvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_PTPN9_pd Subfamily PTPN9 646-809 8.2e-26 85.7 In-house 99-275 (297) alignment 
Range on Protein: 646-809
Range on HMM: 99-275/297.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMI
. ||.|. ...|  |||  .  |. .  | ||||. .. .   |..... .. .... | .|..|.|| .|. ...|| ||.. |   |  .. ...| .
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

IEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 646-815 1.2e-25 85.0 In-house 78-255 (270) alignment 
Range on Protein: 646-815
Range on HMM: 78-255/270.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA---LVTGEYNITLLNENTNNRYIERKFEVKnnNTGAKQSVTQFQITNWDSTGEVKNP----
..||.|| ...||||||. . .|.... | .|||. ..    | .|. ... |.|. .. || .. ...  ..| .. .. |. ..|   | ....    
ksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedssl

--QTILMIIEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
  . .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||... ...
stdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyef
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 646-820 1.5e-24 81.3 In-house 94-271 (287) alignment 
Range on Protein: 646-820
Range on HMM: 94-271/287.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNE-NTNNRYIERKFEVKNNNTGAKQSVTQFQITNWdsTGEVKNPQ---TI
| ||... .......... .| |. .  ||.|||     .  | | ..||.  . .  |  | . . . .|   . | |... .|    .|  |     |
rdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavgli

LMIIEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYLPYE
 ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.||  || | ||
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv..qlrllye
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 646-810 9.4e-23 75.5 In-house 86-245 (267) alignment 
Range on Protein: 646-810
Range on HMM: 86-245/267.0
RHFWKMIDDRNVTAIVMLCQENENNqeVCyQYWPSA-SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKqSVTQFQITNWDSTGEVKNPQTILmi
 .|...| |..|. ||.| .  ..|  .  ..||    .|    .  .    |. .| |    .|.| .|  |.  || .   .|.   . |     |  
tdfltvihdqkvpvivlltkvftdn..ir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkwnintnnkpylkpl..

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
0051429 (Phosphotyrosine protein) phosphatases II 646-815 1.1e-22 76.5 In-house 36-216 (272) alignment 
Range on Protein: 646-815
Range on HMM: 36-216/272.0
RHFWKMiDDRNVTAIVMLCQENENNQEVCYQYWP-----------SASNALVTGEYNITLLNENTNNRYIERKFEVKNN-NTGAKQSVTQFQITNWDSTG
..||..  . ....||.|..|.| ... |..|||           ..      | . .||| | . . || |......  ..|.   |.... |.|   |
adfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

EVKNPqtILMIIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVVSVQL
  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.|||   .. 
vpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylf
0043147 (Phosphotyrosine protein) phosphatases II 646-821 6e-20 67.1 In-house 34-158 (172) alignment 
Range on Protein: 646-821
Range on HMM: 34-158/172.0
RHFWKMIDDRNVTAIVMLCQEnennqevcyqywpsasnalvtgeynitllnentnnryierkfevKNNNTGAKQSVTQFQITNWDSTGEVkNPQTILMII
 .||.|. ....|.||.|...                                             .. .. .... |.. ..|.  |   ... .| ..
adfwrmlkelgithivnltel............................................lydpellerlgiqylylpwpDhgvp.llelllefl

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVVSVQLYLPYED
| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.    .. . .|.
efidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyfek
0046846 (Phosphotyrosine protein) phosphatases II 646-810 3.6e-19 64.6 In-house 37-159 (176) alignment 
Range on Protein: 646-810
Range on HMM: 37-159/176.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVtgeynitllnentnnryierkfevknnntgakqsvtQFQITNWDSTGEVKNpQTILMII
 .|..|. . ..||.|.|..| | ..  |..|||   .. .                                    |.. ..|.  |     . .| ..
adflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl.elllell

EEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| 
efirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp
0044763 (Phosphotyrosine protein) phosphatases II 646-809 1.3e-17 59.4 In-house 38-156 (178) alignment 
Range on Protein: 646-809
Range on HMM: 38-156/178.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNalvtgeynitllnentnnryierkfevknnntgakqsvTQFQITNWDSTGEVKNPQTILMII
 ...... . ..|.||.|..| |.... |..|||.  .                                       |.. ....  |.   .. .| ..
addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhipipDhgvpdllehflefv

EEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
efieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 646-812 1.2e-15 51.7 In-house 105-276 (302) alignment 
Range on Protein: 646-812
Range on HMM: 105-276/302.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENTN-NRYIER------KFEVKNNNTG--AKQSVTQFQITNWDSTGEV
  .| .|.. ||. .| ||.  |.... | .|.     . |  |.| .. .. .|. ... ..      . |.||...    |..|  .. . |   |  
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGap

KNPQTILMIIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
|...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.   
keaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 646-811 2e-15 51.2 In-house 105-266 (439) alignment 
Range on Protein: 646-811
Range on HMM: 105-266/439.0
RHFWKMIDDRNVTAIVMLCQENEnnqevCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKNNNT--GAKQSVTQFQITNWDSTGEVKNPQTILM
 .||... ..... ||||..  |      |.|||| ... . |.  .    .    .|. | | | |.      ...| ||. . |       .   .| 
ddfwrlviekktvtivmltnlve.....sykywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

IIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 646-812 6.6e-15 49.9 In-house 96-265 (307) alignment 
Range on Protein: 646-812
Range on HMM: 96-265/307.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNNRYI--ERK-F---EVKNNNTGAKQSVTQFQITNWDSTGevkNP
 .|| |. . .| ...|||.  |  .  | ||||    . || || . |.  .|   . .  . .     ..| . ..  ......| .||   |    |
ysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vp

QTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
|. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| . 
qinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 646-812 7e-13 43.2 In-house 96-259 (288) alignment 
Range on Protein: 646-812
Range on HMM: 96-259/288.0
RHFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTnnRYIERKFE---VKNNNTGAKQS-VTQFQITNWDSTGEVKNPQTI
  .|||. . .|  |||||.  |  .|   .|.||     .    . |   ..     |..  .   ......| ..  | .  . .||  |  .| .. 
eelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsp

LMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
| ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..||   
lrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemq
subfamily_PTPRD_pd Subfamily PTPRD 647-809 2.9e-44 146.7 In-house 106-266 (564) alignment 
Range on Protein: 647-809
Range on HMM: 106-266/564.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
 ||.|. ..|.. |||| . .|.... | .|||. .     ||. .|| .|.. . |. |.|..|....  .. |.||. |.| ..|  ......| .|.
dFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

EMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
kvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 647-810 3.4e-40 133.2 In-house 114-276 (298) alignment 
Range on Protein: 647-810
Range on HMM: 114-276/298.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
 ||.|. ......|||| . .| ..  . .|||.  ..   || ...||....   .| ||..|.....  ...| |.. |.| . |. .| ...| ...
dFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

EMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| 
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 647-810 6.3e-35 115.7 In-house 106-269 (319) alignment 
Range on Protein: 647-810
Range on HMM: 106-269/319.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAsNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA-KQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. ....  .|||.. .|. .  . .|||.. |  . |.. .||..|.  . || ||........     .|..|| |.|   .  .. ...| ..
dfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. 
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp
subfamily_PTPRA_pd Subfamily PTPRA 647-812 1.5e-34 114.3 In-house 116-283 (330) alignment 
Range on Protein: 647-812
Range on HMM: 116-283/330.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNPQTIL
 ||.|| ... ..|||| . .| ..| |.||||.   ..  |. .... .|.  . |  ||| |..     .  ... |.||  | |   |   .|. .|
dfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGml

MIIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||   
kllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 647-814 2.7e-34 113.5 In-house 99-266 (281) alignment 
Range on Protein: 647-814
Range on HMM: 99-266/281.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVkNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
.||.|. ...|.||||. .| |...  |..|||  ...|  |.. .. ..|.....||||||.. ....| ...|.|.. |.|  .|  .... .|   .
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrk

EMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSVQ
|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||  .
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqye
subfamily_PTPN12_pd Subfamily PTPN12 647-810 3e-33 110.0 In-house 98-263 (290) alignment 
Range on Protein: 647-810
Range on HMM: 98-263/290.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV-TGEYNITLLNENTNN-RYIERKFEVKNNntGAKQSVTQFQITNWDSTGEVKNPQTILMI
 ||.||.. ||. .||.|.| |...  | .|||.  .  . .||...|| .|.. .  .. | ..|...  .....|.||. |.|   |  ......| .
dfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllel

IEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
||.. ..|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| 
ielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk
subfamily_PTPN6_pd Subfamily PTPN6 647-812 1.4e-32 108.0 In-house 113-285 (306) alignment 
Range on Protein: 647-812
Range on HMM: 113-285/306.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVK-NNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. . | . |||. .|.| ..| |..|||....   .|....| ..|.....|| |.. |. ... . ...| |.. ..|   |  |.|...|  .
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVS
|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||   
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqq
subfamily_PTPN23_pd Subfamily PTPN23 647-814 6.7e-32 105.4 In-house 98-270 (288) alignment 
Range on Protein: 647-814
Range on HMM: 98-270/288.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. .. .  |||| ...| ... . .|||.. . . . |....|| .... . ..||..... ... |..||.  |.|.| . |  . |.|.| ..
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

EE---MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
.|   .|...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..  ..
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 647-809 6.7e-32 105.6 In-house 102-262 (315) alignment 
Range on Protein: 647-809
Range on HMM: 102-262/315.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS-ASNALVTGEYNITLLNENTNNRYIERKFEVKNNNtgAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. . .||.|||. . .|...  | ||||   ...   |.....||. ...   . ||. ... .  ... ||||| |.|   |  |.  ..| .|
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllkli

EEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||
kevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt
subfamily_Ptp69D_pd Subfamily Ptp69D 647-810 7.1e-32 105.7 In-house 106-272 (307) alignment 
Range on Protein: 647-810
Range on HMM: 106-272/307.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAsNALVTGEYNITLLNENTNNRYIERKFEVKNNN-----TGAKQSVTQFQITNWDSTGEVKNPQTI
 ||.|| . .|| |||| ...| |.. | .|||   .    |. ...| .|.. . ||.|...| ...       ... |.|.. |.|. .   . ....
DfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

LMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .||...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  
lklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 647-811 1.6e-31 104.5 In-house 105-266 (288) alignment 
Range on Protein: 647-811
Range on HMM: 105-266/288.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKnnNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIE
.||... ..... |||| .  |.... | .|||.| .    |. ..||..... . ...||....   .. .  .||.| . |  .|  .. . .| ...
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr

EMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||. 
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 647-810 1.2e-30 101.7 In-house 107-270 (297) alignment 
Range on Protein: 647-810
Range on HMM: 107-270/297.0
HFWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASNALvTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVK--NPQTILMI
 ||.|. | .|..|||| ..||...  | .||.  . .   |.  ..||  .  . .|.|..||..... |.. | |.| ..| .  . .  . ...| .
dfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllkl

IEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  ||| 
isevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk
subfamily_PTPRG_pd Subfamily PTPRG 647-809 8.8e-30 98.4 In-house 106-272 (563) alignment 
Range on Protein: 647-809
Range on HMM: 106-272/563.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSaSNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAK------QSVTQFQITNWDSTGEVKNPQT
 ||.|| ..||. |||. . .|.... | .|||.  ...  |. ..|| .|..   | .|.. .|| .  .|      . |.|.. |.|  .|  . .  
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

ILMIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||
vLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 647-811 1e-29 98.7 In-house 106-275 (325) alignment 
Range on Protein: 647-811
Range on HMM: 106-275/325.0
HFWKMIDDRNvTAIVMLCQENENNQEVCYQYWPSA-SNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 .|... | . ...|..  | ..... | .|||   ...   |  .. |   ..   |. |...||. . |  .|| |||.  ||  |  | | |.. |.
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

EEM---YRTQR--KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
. .     . .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| 
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 647-810 3.1e-28 93.6 In-house 88-254 (274) alignment 
Range on Protein: 647-810
Range on HMM: 88-254/274.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEY---NITLLNENTNNRYIERKFEVKNNNTgaKQSVTQFQITNWDSTGEVKNPQTILM
 ||.||  ..|. |||| . .|.|.. | .|.| | .. ....|   .|.  . ...| |  ||. .|. .   ..||. .  |.|  .   ....|.| 
dfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlld

IIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | ||| 
lvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 647-813 4.3e-28 93.5 In-house 119-280 (319) alignment 
Range on Protein: 647-813
Range on HMM: 119-280/319.0
HFWKMIDDRNVTAIVMLCqenennQEVCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|| . |...||.|       .. | ||||   .    ..... .   .  . |. |..|. .  .   ....||| .  |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

EE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 647-813 7e-28 92.9 In-house 83-244 (284) alignment 
Range on Protein: 647-813
Range on HMM: 83-244/284.0
HFWKMIDDRNVTAIVMLCqenennQEVCYQYWPSASNAlVTGEYNITLLNENTNNRYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|| . |...||.|       .. | ||||   .    ..... .   .  . |. |..|. .  .   .....|| .  |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlv

EE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  
kkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_PTPRN_pd Subfamily PTPRN 647-812 2.1e-25 84.0 In-house 115-280 (297) alignment 
Range on Protein: 647-812
Range on HMM: 115-280/297.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNAlVTGEYNITLLNENT-NNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMII
.||.|. .. |. ||.|.. .|.. . |..|||   .. | . |.. |. |    . |. | | .|| .|   ..||||    | ..|   .....|   
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr

EEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
  . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|   
rkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq
subfamily_CG7180_pd Subfamily CG7180 647-810 3e-23 76.9 In-house 100-276 (296) alignment 
Range on Protein: 647-810
Range on HMM: 100-276/296.0
HFWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASnALVTGEYNITLLNENTNNRYIERKFEVKNN-------NTGA---KQSVTQFQITNWDSTGEVK
 ||... |... |.|.|... . ..  . .|||  |     ||  . ...|..      |.| .. .       ...    .  |..||.| |..  .| 
efWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP

NPQTILMIIEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
   . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|
lstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv
0049260 (Phosphotyrosine protein) phosphatases II 647-817 4.4e-21 70.6 In-house 24-143 (152) alignment 
Range on Protein: 647-817
Range on HMM: 24-143/152.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWpsasnalvtgeynitllnentnnryierkfevknnntgakqsvtQFQITNWDSTGEVKNPQTILMIIE
.||.|. . ..|.||||... |.. . |.||.                                            |.. ..|.  |  ...| .|....
dfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllflll

EMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVVSVQLYL
 . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..    .. .
fiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 647-809 2.5e-20 67.7 In-house 60-224 (237) alignment 
Range on Protein: 647-809
Range on HMM: 60-224/237.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA-KQSVTQFQITNWDSTGEVKNPQTILMII
 ||.|. . . . ||||    |.|.. |..||||. .    | . ..|  ..    |  | . . .. |    . . |.|.| |   |  ..  ..| . 
dfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfr

EEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .||
kniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 647-810 2.8e-20 67.1 In-house 109-269 (290) alignment 
Range on Protein: 647-810
Range on HMM: 109-269/290.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPS-ASNALVTGEYNITLLNENTN-NRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGeVknPQTILMI
 .|.|. . .|.||||||.  |. .  | ||.|  . ..|  ||. ..  .|... .. | . . |.. ..| .  .  ..|  |     |  ... | .
diwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.v..alstlal

IEeMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTV
.  . |. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .|||  
lr.tlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 647-803 8.6e-17 56.2 In-house 82-238 (290) alignment 
Range on Protein: 647-803
Range on HMM: 82-238/290.0
HFWKMIDDRNVTAIVMLCQENENNQE----VCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNtGAKQSVTQFQITNWDSTGEVKNPQTI
.|| |. . .|. .||||. .|....     | .| | . .  |  .  ..   .  ...  ..|. .|| .. . .  ||  .. .|...   ....|.
kfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktl

LMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQK
| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.
lsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 647-812 2.8e-16 54.0 In-house 96-257 (281) alignment 
Range on Protein: 647-812
Range on HMM: 96-257/281.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNA-LVTGEYNITLLNENTNNRYIERKFEVknNNTGAKQSVTQFQITNWDSTgEVKNPQTILMii
 ||.|| . | ||||||||  | |.| | .|.|  . . |   .. ..  .   |.  .  ....     |  . .|..   .|    .| .   ...  
dfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdw.qvpessevml..

eEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVVS
 .. |  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||.  
.kilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 647-812 1.7e-13 44.9 In-house 111-277 (305) alignment 
Range on Protein: 647-812
Range on HMM: 111-277/305.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNeNTNNRYIERKFEVKNN------NTGAKQSVTQFQITNWDSTGEvknPQT
.|| |. ...|  |||||.  |  .  | |||| |    ..    | . |  . .. .||  |..        . . | || ..| |.|   |    |  
efwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivven.vsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppc

ILMIIEEMYRTqRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVS
 |  .| .    |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. | 
kltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 647-811 2.2e-11 38.3 In-house 90-257 (285) alignment 
Range on Protein: 647-811
Range on HMM: 90-257/285.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV-TGEYNITLLN--ENTNNRYIERKFEVKNNNTGAKQS--VTQFQITNWDSTGevkNPQTI
 ||.|| . ... ..|||   |   | |  |.|     .|  |.|.||| .  |..    |   . | | .  . .   . . |.  |        |.  
dfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdql...apeda

LMIIeEMYRTQRK--RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
  .| |.|.  .|    .. |.||||  |||.| |     .  .   .  |.......  |  .  .||. .
rpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 647-808 5.8e-11 36.9 In-house 19-187 (198) alignment 
Range on Protein: 647-808
Range on HMM: 19-187/198.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA--KQSVTQFQITNWD--STGEVKNPQTI
 ||.|. .     |||. ... |..     |||.. . .   |  ..|     |.  |    . . || |     . ....|.| |   .| .|     .
dfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgf

LMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
..   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
vvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 647-808 6.1e-11 36.9 In-house 20-188 (199) alignment 
Range on Protein: 647-808
Range on HMM: 20-188/199.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASN-ALVTGEYNITLLNENTNNRYIERKFEVKNNNTGA--KQSVTQFQITNWD--STGEVKNPQTI
 ||.|. .     |||. ... |..     |||.. . .   |  ..|     |.  |    . . || |     . ....|.| |   .| .|     .
dfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgf

LMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
..   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
vvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis
subfamily_egg_pd Subfamily egg 647-811 1.5e-10 35.3 In-house 98-257 (307) alignment 
Range on Protein: 647-811
Range on HMM: 98-257/307.0
HFWKMIDDRNVTAIVMLCQENENnqEVCYQYWPSA-SNALVT--GEYNITLLNENTNNRYIERKFEVKN--NNtGAKQSVTQFQiTNWDSTGEVKNPQTI
 ||.|.   .|  ||||    |.  | |  ||| | |..|||  | ..|. |. . .   . |  ..|    .   .. .  .|  ... ...|  |  .
dfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq.gdvnnssdvysplrv

LmiieemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVV
|       |  |.   . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|.
l.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 647-811 1.5e-09 31.9 In-house 109-277 (310) alignment 
Range on Protein: 647-811
Range on HMM: 109-277/310.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIER---KF---EVKNNNTGAKQSVTQFQITNWDSTGEVKNPQT
 ||.|| .    .|..||.  |. .  |  ||||   .   |   .| |.| ...  |      |   .|  ..  |.    . .. .|    .   |. 
dfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde

ILMIIEEMYRTQRKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
    . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| .
kchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtel
subfamily_ptpA1_pd Subfamily ptpA1 647-785 2.1e-09 31.6 In-house 104-257 (418) alignment 
Range on Protein: 647-785
Range on HMM: 104-257/418.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS----------NALVTGEYNITLLNEN--TNNRYIERkfEVKNNNTGAKQSVTQFQITNWDSTGE
 ||.|. .  .  |||| .|.|| .  | .|||                | | |.. |..     .   | |  ...    |  . .||.|   |     
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfegetrditqyqyegwpdhni

VKNPQTILMIIEEMYRTQRK-----RGNTSIVVHCSDTVGRSAMFCAAATTINKCK
    | .  ..  .   | .       |  |.||||  |||.  ||.|   ..|  
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 647-810 9.6e-09 29.1 In-house 108-271 (302) alignment 
Range on Protein: 647-810
Range on HMM: 108-271/302.0
HFWKMIDDRNVTAIVMLCQENENNQeVCYQYWPSASNALVtgEYNITLLNENTNNRYIERK----FEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTIL
.||.|. ..... .|.| .|.| ..    ...|  |.. .  ||.   .|    ..  | |     ||  ..      ..   .||| ..   ..  .. 
eFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk..eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli

MIIEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  .....  .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|...
ktaakvfa.kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 647-809 1.3e-08 29.0 In-house 103-272 (305) alignment 
Range on Protein: 647-809
Range on HMM: 103-272/305.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALV---TGEYNITLLNENTNNRYIERKFEVKNNN--------TGAKQSVTQFQITNWDSTGev
 || |  . .| || |||.  |   . |..|..|  .  .    ..  |..  | ...  .... . | ..         . .. ||..   .|   |  
dfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg..

kNPQTILMIIEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQT
  | . | |.| . ...  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.||
.vpaadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 647-701 9.8e-08 26.2 In-house 91-146 (297) alignment 
Range on Protein: 647-701
Range on HMM: 91-146/297.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNN
 ||... ...| .|||... .|. .. |. ||||.  . | .|.. .  | . ...
dfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 647-713 8.6e-07 23.0 In-house 119-185 (350) alignment 
Range on Protein: 647-713
Range on HMM: 119-185/350.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNN
 |.|.|   .|. |..| .. |.| | ||.||.  |   .|   . .  |    |    . ..||..
dfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkke
subfamily_eak_pd Subfamily eak 647-734 9.4e-07 22.5 In-house 108-194 (332) alignment 
Range on Protein: 647-734
Range on HMM: 108-194/332.0
HFWKMIDDRNVTAIVMLCQENENNQEVCYQYWPSAS-NALVTGEYNITLLNENTNNRYIERKFEVKNNNTGakQSVTQFQITNWDSTGE
 ||.|. ...  |||.| .. |.. |   .|.|  . . |  | ....  .   .| .  |..|..  |      |  ...  |  |  
afwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 647-729 1.4e-06 22.0 In-house 251-328 (440) alignment 
Range on Protein: 647-729
Range on HMM: 251-328/440.0
HFWKMIDDRNVTAIVMLCQENennQEVCYQYWPSASNALVTGEYNITLLNENTNNRYIERKFEVKNNNTgaKQSVTQFQITNW
 ||... | ....|.|| | |   .  |  |||  . ..  | . .     .  ||   | .|.| ..    . . ||..  |
dfwrlvhdyristiimlnqln...dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee..vheirqfevqtw
0048179 (Phosphotyrosine protein) phosphatases II 670-811 6.2e-12 41.0 In-house 43-132 (144) alignment 
Range on Protein: 670-811
Range on HMM: 43-132/144.0
NQEVCYqywpsasnalvtgeynitllnentnnryierkfevknnntgakqsVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkrGNTSIVVHCSDTVG
. . ..                                             ..|.. ..|.  |    .. .| ..| . . ..   .  ..||||  ||
eflere.............................................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvg

RSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVV
|.....||   .    ..| ......|.  | . ||.|..  
Rtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg
Filo_glycop Filovirus glycoprotein 695-762 4.5e-06 13.5 Pfam-A 191-260 (364) alignment 
Range on Protein: 695-762
Range on HMM: 191-260/364.0
LNENTNNRYIERKFEVKNNNTGAKQSVTQFQI--TNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVV
 .|.. ..|.  . | . ...|...| . |..  |..    . . ||... . |....|...   |  ..
mtedstskYatstleyevedfGteeseiLfevdnttyvqlersltPqfLvqlnetikltnkrsnttgkli
0048076 (Phosphotyrosine protein) phosphatases II 697-810 6.1e-12 40.9 In-house 23-129 (145) alignment 
Range on Protein: 697-810
Range on HMM: 23-129/145.0
ENTNNRYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVL
|.  .  | . . . .. .. .. ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|
ellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KSQRIQKPGSVQTV
.  | | ||.|...
elvrsqrpgavpnp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 703-779 5.5e-07 23.6 In-house 200-284 (350) alignment 
Range on Protein: 703-779
Range on HMM: 200-284/350.0
YIERKFEVKNNNTGAKQsVTQFQITNWDSTGEVKNPQTILMIIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAAT
  .   ...   .     | |.|. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....   
dnnsltaitlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 719-810 6.4e-11 36.2 In-house 89-180 (440) alignment 
Range on Protein: 719-810
Range on HMM: 89-180/440.0
QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... |..   |   |  |    .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp
PTPc_DSPc_SM00012 721-810 6.6e-19 63.4 In-house 2-93 (105) alignment 
Range on Protein: 721-810
Range on HMM: 2-93/105.0
VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 746-814 3e-06 21.3 In-house 218-285 (297) alignment 
Range on Protein: 746-814
Range on HMM: 218-285/297.0
EEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
 | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.   .
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe