Gene PTPRD-29 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP083_AA protein Get Run
AqueP083_AA_246-413 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 7-77 2.7e-06 20.6 Pfam-A 2-76 (85) alignment 
Range on Protein: 7-77
Range on HMM: 2-76/85.0
TPTGLNATRLstGLAHVKLSWSTV----SGATGYEVYYQQPNSTP--VSVSNTSSTTINITSGLFRGITYTFDVVSY
 |..|...    .   . ||||      .  ||||| |.. ...   ........||  . .||  | .|.| | ..
aPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
fn3 Fibronectin type III domain 98-181 5.3e-14 45.3 Pfam-A 2-83 (85) alignment 
Range on Protein: 98-181
Range on HMM: 2-83/85.0
PVGDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSDT-SYTVNITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
..... .|.| | |.|.||.. .   ..|||||| ..| . ..   . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 153-420 1.3e-44 147.1 In-house 171-301 (301) alignment 
Range on Protein: 153-420
Range on HMM: 171-301/301.0
Nrmynltglipytnytvsiipynynmngparqeiqltgesipgvisdlrhsrppteitivwnpptipngiitvyeiryreststgpynitnttntyysil
                |                                                                                   
n...................................................................................................

glipntsytigvraytsigpgewtdrgyttteiqtfNGYIERKFEVKNNNtgATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHC
                                    ||||||||.||...  ....|.|.|.|.|   | . .|.|.|.||...  .|.| |   .||||
....................................ngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHC

SDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
||||||| ..|.   ..  || |||.||||| |. | .||| |.| .||  |.... .||   .||.|
SdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
fn3 Fibronectin type III domain 206-275 2.5e-14 46.3 Pfam-A 13-84 (85) alignment 
Range on Protein: 206-275
Range on HMM: 13-84/85.0
PTEITIVWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYSILGLIPNTSYTIGVRAYTSIGPGEW
.|..|. |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
stsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
0049772 (Phosphotyrosine protein) phosphatases II 247-418 1.5e-12 43.4 In-house 155-286 (314) alignment 
Range on Protein: 247-418
Range on HMM: 155-286/314.0
TyysilglipntsytigvraytsigpGEWTDRGYTTTEiqtfngyierkfEVKNNNTGATQSVTQYQITNWDLtGKLTNPQTILMVIEEMYRTqrkRGNT
.                         .|.| . . . .            |. ...   .. . .|  ....  |    .. .. ..| . .    . ..
g.........................neptaadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkgg

SIVVHCSDTVSRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVQQYQGIFQIVLTYLDSFETY
 ..|||.. ..|.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. ....
pvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 260-419 8.2e-75 246.4 In-house 152-290 (290) alignment 
Range on Protein: 260-419
Range on HMM: 152-290/290.0
YtigvraytsigpgewtdrgyttTEIQTFNGYIERKFEVKNNNT-GATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSR
                       .. .|.|.|||||.||||.|. ||.|||||||||||| |||.|||||||.||||||.||||||||||||||||||.|
l......................lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgr

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
savfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
0036282 (Phosphotyrosine protein) phosphatases II 261-406 1.3e-17 59.5 In-house 60-164 (174) alignment 
Range on Protein: 261-406
Range on HMM: 60-164/174.0
TigvraytsigpgewtdrgyttteiqtfngyierkfevknNNTGATQSVTQYQITNWDLTGKLTNPQtILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSA
.                                       . .  .... ||. ..|.  |  . .. .| ....... . . ..  ..||||  |.|..
e.......................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

MFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
...||   .   . |...|........| |.||.||| .||. . .
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 268-407 4.5e-09 30.7 In-house 54-199 (199) alignment 
Range on Protein: 268-407
Range on HMM: 54-199/199.0
TSIGPGEWTDRGYTTTEIQTFNGYIERKFEVKNNNTG--ATQSVTQYQITNWDltgKLTNPQTIL-----MVIEEMYRTQRKRGNTSIVVHCSDTVSRSA
|  | |...    ||  | |   |    . . || |   .|. ...||.| |    . | |.  |     .   |. .   .  .. ..|||||    . 
tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk...ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftg

MFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
.| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
vfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 268-407 4.5e-09 30.8 In-house 53-198 (198) alignment 
Range on Protein: 268-407
Range on HMM: 53-198/198.0
TSIGPGEWTDRGYTTTEIQTFNGYIERKFEVKNNNTG--ATQSVTQYQITNWDltgKLTNPQTIL-----MVIEEMYRTQRKRGNTSIVVHCSDTVSRSA
|  | |...    ||  | |   |    . . || |   .|. ...||.| |    . | |.  |     .   |. .   .  .. ..|||||    . 
tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk...ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftg

MFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
.| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
vfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
0051429 (Phosphotyrosine protein) phosphatases II 275-415 3.9e-17 58.3 In-house 87-228 (272) alignment 
Range on Protein: 275-415
Range on HMM: 87-228/272.0
WTDRGYTTTEIQTFNGYIERKFEVKNN-NTGATQSVTQYQITNWDLTGKLTNPqtILMVIEEMYRtqrkrgNTSIVVHCSDTVSRSAMFCAAATTINKCK
. .  .|........ || |......  ..|..  |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .    
ygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvs

TEGVID--------VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
 | ..|        ......  | | ||.||| .||. .....| .|.|.
letivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0037934 (Phosphotyrosine protein) phosphatases II 276-411 2.8e-22 74.9 In-house 101-241 (243) alignment 
Range on Protein: 276-411
Range on HMM: 101-241/243.0
TDRGYTTTEIQTFNGYIERKFEVKNNN-TGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRK-------RGNTSIVVHCSDTVSRSAMFCAAAT
 |   |.........|. |.....| . .. |. |..|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||  |.|.....|| .
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

TINKCkteGvIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTY
 . ..   | .|.....|  | |.|| .||| .||. . ...| .
mllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 280-412 2e-27 92.2 In-house 167-304 (307) alignment 
Range on Protein: 280-412
Range on HMM: 167-304/307.0
YTTTEIQTFNGYIERKFEVKNN-NTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV
 |...... .||. |..||...  || .  ||... |.|  .|  ......|  |||. . ...  ... ..||||. |.|...|.|| . .   ..||.
vtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegt

---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
   .|.....|  | |.||.||. .||. . ...| .|
lldvdlleavkllreqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 280-412 5.2e-27 90.2 In-house 111-243 (245) alignment 
Range on Protein: 280-412
Range on HMM: 111-243/245.0
YTTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID
 |.........|. |..||.|. .. .. |..|. ..|.  |  ......| ..|.. . ... .|. ..||||. |.|...|.|| . ..  ..|. ..
vtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.....|  | |.||.||| .||. . ...| .|
leeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 280-410 1.3e-26 88.2 In-house 134-264 (283) alignment 
Range on Protein: 280-410
Range on HMM: 134-264/283.0
YTTTEIQTFNGYIERKFEVKNN-NTGATQSVTQYQITNWdltgKLTNPQTILMVI---EEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE
 |  .  | | .| ... ...|  . .|  .. ||. .|       ..|.|.  .   . .   |..  .. |||||| .. |.|.|.||...... .||
vtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdalte

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 |.|||.|.|  | |... ||| .||. . ..|| 
svvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN9_pd Subfamily PTPN9 280-412 8.9e-16 52.8 In-house 146-290 (297) alignment 
Range on Protein: 280-412
Range on HMM: 146-290/297.0
YTTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQR---------KRG---NTSIVVHCSDTVSRSAMFCAAAT
 .. |... . | .|..|.|| .|. ...|| .|.. |   |   . ...| |.|.. ..|          ..|   .  ||||||  . |.  |..   
vsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldi

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.... ...|..||....|  | |.  |.|| .||.  .. || | 
clsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0050432 (Phosphotyrosine protein) phosphatases II 281-420 9.6e-32 105.9 In-house 171-307 (308) alignment 
Range on Protein: 281-420
Range on HMM: 171-307/308.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQrkrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
|.........|. |..|..|...| .  ||... |||   |  ..|. .|  .|.. ...   ..  ||||||. |.|.. |.|. . ..  ..|| .||
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
|...|  | |.||.|||..||. .....| || ...|. |
feavkklReqRpgmvqtpeqylflyralleylklkltkln
0036941 (Phosphotyrosine protein) phosphatases II 281-418 1.1e-30 102.4 In-house 140-283 (297) alignment 
Range on Protein: 281-418
Range on HMM: 140-283/297.0
TTTEIQT--FNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCK---T
|......  ...|. |..||.....| .  ||....|.|.  |  ..|...|  ||.. . ...  ... ..||||. |.||..|.|| . ..  .   .
tllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklk

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
|| .|.....|. | |.||.|||..||. . ...| .| ...|.
eggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0046845 (Phosphotyrosine protein) phosphatases II 281-420 4.3e-30 100.5 In-house 138-282 (284) alignment 
Range on Protein: 281-420
Range on HMM: 138-282/284.0
TTTEIQTFNGYIERKFEVKNNN-TGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRK-RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEG--
|.........|. |..|..|.. || .  ||....|.|   |  ..|. .|  .... . ...  |.  ||||||. |.|...|.|. . ..  ..||  
tllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekegll

-VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
 ..||....|  | |.||.|||..||. .....| || .. |. .
lgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0040438 (Phosphotyrosine protein) phosphatases II 281-418 7.7e-30 99.7 In-house 146-282 (317) alignment 
Range on Protein: 281-418
Range on HMM: 146-282/317.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
|...... .|.. |..||...... .  ||... |.|.  |   .|...|  .|.. . .. .... ..||||. |.|...|.|| . .. ...|| .||
tllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
....|  | |.||.||| .||. . ...| ||  ..|.
eeavkelreqRpgavqtpeqyrflydalleylkrkltl
0047943 (Phosphotyrosine protein) phosphatases II 281-412 4.7e-29 97.1 In-house 140-272 (273) alignment 
Range on Protein: 281-412
Range on HMM: 140-272/273.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID
|.....|...|. |..|..|..|| .  ||... |.|   |  .... .|  ||.. .....  .|. .|||||. |.|...|.|. . ..  ..|| .|
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|....|  | |.||.|||..||. . ...| ||
vleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 281-412 8e-29 96.4 In-house 152-286 (288) alignment 
Range on Protein: 281-412
Range on HMM: 152-286/288.0
TTTEIQTFNGYIERKFEVKNN----NTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEG
|.........|. |..||.|.     .| .. ||... |||   |  ..|. .|  ...... ..  |.  .|||||. |.|...|.|. . ..  ..||
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
..||....|  | |.||.|||..||. .....| ||
gvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 281-416 6.5e-28 93.5 In-house 159-293 (297) alignment 
Range on Protein: 281-416
Range on HMM: 159-293/297.0
TTTEIQTFNGYIERKFEVKNnnTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID
|...... .||. |..||.|  .| .  ||..| |.|   |   .....| ..|.. . ...  ... ..||||. |.|...|.|| . .. ...|| .|
tllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
|....|  | |.||.||| .||. .....| .|  . 
vleavkelreqRpgavqtpsqyrflydallellkrkl
0043336 (Phosphotyrosine protein) phosphatases II 281-412 1.6e-26 88.8 In-house 147-277 (278) alignment 
Range on Protein: 281-412
Range on HMM: 147-277/278.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
|.........|. |..||.|. .| .. ||.|. ..|   |  ......|  .... . ..   |. ..||||. |.|...|.|. . ..  ..|| .|.
tllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdl

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
....|  | |.||.||| .||. .....| ||
eeavkelreqRpgavqtpsqyrflyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 281-412 8.1e-25 83.3 In-house 114-246 (249) alignment 
Range on Protein: 281-412
Range on HMM: 114-246/249.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID
|.........|. |..|..|. .| .  |...|.|.|  .|   .....|  ||..   ...   .. ..||||. |.|...|.|| . ..  ..|. .|
tllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.....|  | |.||.||. .||. . ...| .|
leeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 281-413 2.1e-24 81.8 In-house 124-273 (278) alignment 
Range on Protein: 281-413
Range on HMM: 124-273/278.0
TTTEIQTFNGYIERKFEVKNN----NTGATQSVTQYQITNWDLTGKLTNP--QTILMVIEEMYRTQR------------KRGNTSIVVHCSDTVSRSAMF
|........ |. |...| |     ... .  ||......|.  |  ..|  . .| ..|.. . ..              ... ..||||  |.|....
tllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl

CAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTYLD
.|| . .  .  ||..|.....|  | |.|| .||. .||. ... .| .| 
vaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 281-417 2.3e-23 77.8 In-house 151-289 (297) alignment 
Range on Protein: 281-417
Range on HMM: 151-289/297.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLT--NPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVI
... ..  .|.|.|..||..... |.. | ||| ..|         . ...| .|.|.  .  .. .. ..|||.  | | .....    . . | |  .
vllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekev

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
|.|...|  | ..|  ||| .||. ....|| .| | .|
difglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 281-413 9.1e-21 69.1 In-house 137-269 (274) alignment 
Range on Protein: 281-413
Range on HMM: 137-269/274.0
TTTEIQTFNGYIERKFEVKNNNTgaTQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNT--SIVVHCSDTVSRSAMFCAAATTINKCKTEGVI
....| . |.|  ||. .|. .   ..||. |  |.|  .    ...|.| ...|. ...... .   ..|||||  . |  .| |.  .... . |.|.
kvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
||...    |... | ||| .||. |....  || 
dvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN23_pd Subfamily PTPN23 281-412 2.2e-20 67.7 In-house 145-280 (288) alignment 
Range on Protein: 281-412
Range on HMM: 145-280/288.0
TTTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEE---MYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCK-TEG
|  . .. . ..||..... ... |..||.  |.|.|   |    |.|.| ...|   .|...... .| .|||||  | |. .|.   . ... .  .|
tlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgng

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
..|. ||..  | |.  .||...|..  ...||.. 
lldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 281-416 2.2e-20 67.9 In-house 151-285 (288) alignment 
Range on Protein: 281-416
Range on HMM: 151-285/288.0
TTTEIQTFNGYIERKFEVKnnNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
| .| .. . ...||....   ..    .|||| . |  .|   . . .| ... .  .. .     |.||||. | |.  | |. . |.. ..| .|||
tlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL--DSFE
. ...  | |..  |||..||. |....|.    |. .
agtvaklRkqRallvqtlkqYefiyevllslieedgva
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 281-413 3e-20 67.3 In-house 149-278 (315) alignment 
Range on Protein: 281-413
Range on HMM: 149-278/315.0
TTTEIQTFNGYIERKFEVKNNNtgATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTqRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
.. ....  . . ||. ... .  ... |||.| |.|   |   .  ..| .| |.    ... . |..||||  | |. .....   ... | . ..||
ellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
|...|  | ..|  ||| ..|  |...|| .| 
fnfvknlrakrpylvqteeeyafiydavledll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 282-420 4.1e-32 106.5 In-house 150-288 (318) alignment 
Range on Protein: 282-420
Range on HMM: 150-288/318.0
TTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
 .|  ... |. |.|.|..... ... | ||..|.|  .| .... ..| .. .  ..|.| |.. ||||||  | |  .|.|  . ... | |...|||
lkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf

QVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
|. |  | |..  ||| .||. |....| .| |..|. .
qtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_PTPRD_pd Subfamily PTPRD 282-418 2.1e-31 104.2 In-house 152-287 (564) alignment 
Range on Protein: 282-418
Range on HMM: 152-287/564.0
TTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
 .| .... |. |.|..|....  .. |.|.. |.|  .|  ......| .|... ... ....  ||||||  | |. .|..    ... |.|...|..
leeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiy

QVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
|..|  | |..  ||| .||. |....| .|....| 
qyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 282-417 6.2e-29 96.1 In-house 152-288 (319) alignment 
Range on Protein: 282-417
Range on HMM: 152-288/319.0
TTEIQTFNGYIERKFEVKNNNTGA-TQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
  | .  ..|| ||........   | .|...| |.|   .  .. ...| ..... ....|  .  ||||||. | |   |..   .... | |||.||
leeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
|.. .  |.|..  ||. .||. |....| ......|
fstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
DSPc_SM00195 282-412 1e-27 92.5 In-house 132-262 (263) alignment 
Range on Protein: 282-412
Range on HMM: 132-262/263.0
TTEIQTF-NGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
..| ..  . .| |..|......  |..|||||..||   |   ... .| ...... ....  .. ||||||. |.|...|... . ..|...|  .|.
lvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdi

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|...|. | |.||.||| .||. | ...| |.
feivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 282-412 1e-27 92.5 In-house 132-262 (263) alignment 
Range on Protein: 282-412
Range on HMM: 132-262/263.0
TTEIQTF-NGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
..| ..  . .| |..|......  |..|||||..||   |   ... .| ...... ....  .. ||||||. |.|...|... . ..|...|  .|.
lvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdi

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|...|. | |.||.||| .||. | ...| |.
feivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 282-414 5.6e-21 69.9 In-house 146-278 (281) alignment 
Range on Protein: 282-414
Range on HMM: 146-278/281.0
TTEIQTFNGYIERKFEVkNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDV
.|. .. . ||||||.. ....| |..|.| . |.|  .|  .... .|   .|......|. ....|.|||  | |.  . |  . ......|   .||
staeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
 .|... | ..   |||| ||. ....|| .|| 
kavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 282-409 4.3e-12 40.7 In-house 111-237 (239) alignment 
Range on Protein: 282-409
Range on HMM: 111-237/239.0
TTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMViEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
  . . |  || | | . .      . | ||..| |   |      ..| .       .   |    |.|||  | |.  |    . . ..| .  .|.|
lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl.rrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdif

QVLKSQRIQKPGSVQTVQQYQGIFQIVL
. .|. | ..|  ||| .||  |.  ||
nyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 282-409 4.7e-12 40.6 In-house 112-238 (239) alignment 
Range on Protein: 282-409
Range on HMM: 112-238/239.0
TTEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMViEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
  . . |  || | | . .      . | ||..| |   |      ..| .       .   |    |.|||  | |.  |    . . ..| .  .|.|
lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl.rrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdif

QVLKSQRIQKPGSVQTVQQYQGIFQIVL
. .|. | ..|  ||| .||  |.  ||
nyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 283-417 1.3e-36 121.3 In-house 153-288 (305) alignment 
Range on Protein: 283-417
Range on HMM: 153-288/305.0
TEIQTFNGYIERKFEVKN-NNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
.. .|...|||||... . ..   ...|.|||.|.|   |  . . ..| .|... ..|.|  .....||||..|.|. .|.|    ....|.|.|.|||
ksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvf

QVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
.|||  | .... ||| .||. .....  .. ...|
evlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_PTPN6_pd Subfamily PTPN6 283-415 1.6e-19 65.1 In-house 162-300 (306) alignment 
Range on Protein: 283-415
Range on HMM: 162-300/306.0
TEiQTFNGYIERKFEVK-NNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRG---NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV-
.| .. . || |.. |. ... . ...| ||. ..|   |  ..|...|  .|.. | |..     . .||||||. . |   |    . ... ...|. 
se.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgld

--IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
  ||. .. || | |. | ||| |||. ..... .|... 
adidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 283-415 5.1e-10 33.5 In-house 159-286 (290) alignment 
Range on Protein: 283-415
Range on HMM: 159-286/290.0
TEIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTgklTNPQTILMVIeEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTInKCKTEG-VIDVF
 | .  .  | . . |.. ..|    .  ..|  |      . ... | ..  . |. ||  .  .|||||  . |.  | |  ... .. ..|  .|. 
eeddkdaniikktlsvrdkdsGkehklkhlkikswpdk...svalstlall.rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldll

QVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
.. .. |  . .|||   ||  . .|.| .  .|
dlvralrnsrlnsvqvdiqylalveilldlGkdf
Y_phosphatase Protein-tyrosine phosphatase 284-409 5.3e-28 93.4 Pfam-A 108-234 (235) alignment 
Range on Protein: 284-409
Range on HMM: 108-234/235.0
EIQ-TFNGYIERKFEVKNNNTG-ATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
...   ..|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||. |.|...|.|. . ......|. .||.
kekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvl

QVLKSQRIQKPGSVQTVQQYQGIFQIVL
|..|. | |.||.||...||. . ...|
qivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 284-409 5.3e-28 93.4 In-house 108-234 (235) alignment 
Range on Protein: 284-409
Range on HMM: 108-234/235.0
EIQ-TFNGYIERKFEVKNNNTG-ATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
...   ..|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||. |.|...|.|. . ......|. .||.
kekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvl

QVLKSQRIQKPGSVQTVQQYQGIFQIVL
|..|. | |.||.||...||. . ...|
qivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 284-414 3.1e-23 77.4 In-house 155-290 (325) alignment 
Range on Protein: 284-414
Range on HMM: 155-290/325.0
EIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVI---EEMYRTQR--KRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVI
 |...  |. |...||. . | |.|| |.|.  ||  |    | |.. ..   ...  . .   .. | |.||||. | |. .| .  . ..|  .|  .
tieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
|.|...|  | ..|  |.|| ||  |.. .  .. |
difgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_PTPRK_pd Subfamily PTPRK 284-410 5.9e-21 69.6 In-house 148-275 (314) alignment 
Range on Protein: 284-410
Range on HMM: 148-275/314.0
EIQTFNGYIERKFEVKN--NNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVF
| .. . .. | | |..   .  ... | |.| ..|   .  .. ...| .. ..  .| . ..  ||||||    |. .|.| .. ..  ..|||.|||
etellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvf

QVLKSQRIQKPGSVQTVQQYQGIFQIVLT
.. |. | .|.  |.| .||. |....| 
navktlrsrkvnmveteeqykfiydvile
subfamily_PTPRB_pd Subfamily PTPRB 284-414 1.1e-18 62.2 In-house 158-287 (293) alignment 
Range on Protein: 284-414
Range on HMM: 158-287/293.0
EIQTFNGYIERKFEVKNnnTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQ-RKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQ
. .. . .. |......  . ....|.||. | |   |   ...|.|  .... ... ..  .. ||||||  | |.  | |  . ... ..| ..|.| 
aeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifg

VLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.. . | ..   |||..||  | | ||..| .
ivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN13_pd Subfamily PTPN13 284-414 1.8e-17 58.5 In-house 143-271 (273) alignment 
Range on Protein: 284-414
Range on HMM: 143-271/273.0
EIQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQV
..|  .|.  |...||....|... |.. . ..|   |  .... .| .. |. | |.   .. ||||||  . || .. .  . ..  . .  .|| ..
kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkei

LKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
... | |. | ||| .||  .....|. | |
vrklreqrqgvvqtkdqyifvykailevlks
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 285-421 2.9e-71 234.8 In-house 150-287 (287) alignment 
Range on Protein: 285-421
Range on HMM: 150-287/287.0
IQTFNGYIERKFEVKNNN-TGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQV
 .. .||||||.||||.| .|..|.|.|||||||| |||.|.|||||.||||||.|||||||||||||||||| ||||||||||||||||||||||||||
eevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqv

LKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSNF
|||||||||||||||.||..|..|||.|||||||||.|
lksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 285-418 8.6e-33 108.8 In-house 163-296 (298) alignment 
Range on Protein: 285-418
Range on HMM: 163-296/298.0
IQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVL
 ..|  .| ||..|.....  ...| | . |.|   |  .| ...| ..... ..|.. ||....|.||. | ||  |.|  . ... |.| |.|||||.
keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvv

KSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
|  |...||.||| .||  |...|| .||||...
kvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 285-420 2.9e-29 97.0 In-house 115-250 (250) alignment 
Range on Protein: 285-420
Range on HMM: 115-250/250.0
IQTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVL
 ..|  |. ||. . ...    . | |.. ..|   |   . ...| ..... ..|.. ||. ..|.||  |.||  |.|  . ... |.| |.|||.|.
keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvi

KSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
|  |...|..|.. .||  ...|.| .|||.| |..
kvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 285-413 5.8e-20 65.9 In-house 152-277 (515) alignment 
Range on Protein: 285-413
Range on HMM: 152-277/515.0
IQTFNGYIERKFEVKNNNTgaTQSVTQYQITNWDLTGKLTNPQTILMVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVL
...  | | ||..|  ..   .. |||.. |.|   |   . ...| .| |. .... . . ....|||  | |  .....   . . ||  ..|||...
leactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfv

KSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.  | ..|  ||| .||  |...|| .| 
tnirqkrpylvqtqeqyafiygavledll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 285-413 1.5e-16 55.2 In-house 132-265 (270) alignment 
Range on Protein: 285-413
Range on HMM: 132-265/270.0
IQTFNGYIERKFEVKnnNTGATQSVTQYQITNWDLTGK------LTNPQTILMVIEEMYRTQRKRGN-TSIVVHCSDTVSRSAMFCAAATTINKCKTEGV
 .  .||| .. ...  ..| .. .. .. ..|   |        .... .| ..... |....  . . ..||||. | |. .. |  ....  .... 
eekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkk

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.|| ....  | ...  ||...||. ... |..| .
vdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Ptp69D_pd Subfamily Ptp69D 286-415 8.3e-22 72.7 In-house 156-289 (307) alignment 
Range on Protein: 286-415
Range on HMM: 156-289/307.0
QTFNGYIERKFEVKNNN-----TGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDV
.. . ||.|...| ...       ... |.||. |.|. .     ....| .||...  ...  .. ||||||  |.||..| | .  ....|.|  .|.
ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdi

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
|.. |  | |..  ||  .||. ... .| | .  
fetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 286-409 4e-18 60.8 In-house 163-288 (319) alignment 
Range on Protein: 286-409
Range on HMM: 163-288/319.0
QTFNGYIERKFEVKN-NNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEE-MYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQV
.  . |. |..|. .  .    ...||. .  |   |.   |  ......   . |........||||||  | |. .. .  . ... | |  .||...
eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynf

LKSQRIQKPGSVQTVQQYQGIFQIVL
..  | |..  || . ||. |.  .|
vrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 286-410 4.4e-18 60.8 In-house 127-253 (284) alignment 
Range on Protein: 286-410
Range on HMM: 127-253/284.0
QTFNGYIERKFEVKN-NNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEE-MYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQV
.  . |. |..|. .  .    ....|. .  |   |.   |  ......   . |........||||||  | |. .. .  . ... | |  .||...
eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynf

LKSQRIQKPGSVQTVQQYQGIFQIVLT
..  | |..  || . ||. |.  .| 
vrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN3_pd Subfamily PTPN3 286-409 4.8e-16 53.5 In-house 150-272 (280) alignment 
Range on Protein: 286-409
Range on HMM: 150-272/280.0
QTFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLK
.. . |. |.. .|...|   ....| | ..|   |  .... .| ..|.. |..|.  .. .|||||  . |. .. .  |.. .  ..  . . ....
detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivr

SQRIQKPGSVQTVQQYQGIFQIVL
  | |.   |||..||. . . .|
tmrdqramlvqtasqykfvCeail
subfamily_PTPN12_pd Subfamily PTPN12 287-412 1.1e-18 62.2 In-house 152-277 (290) alignment 
Range on Protein: 287-412
Range on HMM: 152-277/290.0
TFNGYIERKFEVKNNntGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQV
. .... | ..|...  .....|.|.. |.|   |  ......| .||.. ..|. . .. .|||||  | |    .|   . .  |.| .   .|||..
vdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdl

LKSQRIQKPGSVQTVQQYQGIFQIVLTYL
. . | |..  ||| .||. ... |. ..
vlelrkqraalvqtkeqyelvykavaelv
0049260 (Phosphotyrosine protein) phosphatases II 287-405 7.4e-13 43.9 In-house 55-143 (152) alignment 
Range on Protein: 287-405
Range on HMM: 55-143/152.0
TfngyierkfevknnntgatqsvtQYQITNWDLTGKLTNPQTILMVIEEMYRTqRKRGNTSIVVHCSDTVSRSAMFCAAATTInkckteGVIDVFQVLKS
                        ||. ..|.  |  ...| .|.... . .  ... .  ..||||  |.|.....||   .        ........ 
i.......................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeaval

QRIQKPGSVQTVQQYQGIF
 | ..||.|.. .|.. ..
vrekRpgavpnpgqlrfly
subfamily_PTPN1_pd Subfamily PTPN1 287-407 1.4e-12 42.0 In-house 142-266 (290) alignment 
Range on Protein: 287-407
Range on HMM: 142-266/290.0
TFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQR-KRGNTSIVVHCSDTVSRSAMFCAAATTIN---KCKTEGVIDVFQ
. . |. |..|..| .|  |......  | |   |    |.. |  . .. ..   ..     |.|||  . ||  || . | .    | .    .|. .
rksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikk

VLKSQRIQKPGSVQTVQQYQGIFQI
||   | .. | .|| .| .  .. 
vllelrkyrlGliqtadqlrfsyla
subfamily_PTPN14_pd Subfamily PTPN14 287-413 1.8e-12 41.9 In-house 163-297 (300) alignment 
Range on Protein: 287-413
Range on HMM: 163-297/300.0
TFNGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNT--------SIVVHCSDTVSRSAMFCAAATTINKCKTEGVI
. . .| .....|   ..  ..|   | |.|   |   .... |  .||.   .||  ..         ..||||. | |. .   .   |.  ... .|
dsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneei

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
|. .||.  | |.   |||. ||. .......||.
dikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 287-409 1.3e-10 36.0 In-house 112-236 (237) alignment 
Range on Protein: 287-409
Range on HMM: 112-236/237.0
TFNGYIERKFEVKNNNTG-ATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVL
 |  |  | . . .. |    . . |||.| |   |   .  ..|    ..    ..    .  ..|||  | |...|    . . ..| . |.|... .
efsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyv

KSQRIQKPGSVQTVQQYQGIFQIVL
.|   ..|  .|| .||  |.| .|
ysieedrpyiiqtkdqyvfihqtil
subfamily_PTPRN_pd Subfamily PTPRN 289-408 5.6e-15 49.8 In-house 169-288 (297) alignment 
Range on Protein: 289-408
Range on HMM: 169-288/297.0
NGYIERKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGnTSIVVHCSDTVSRSAMFCAAATTINKC-KTEGVIDVFQVLKSQ
. |. | | .|| .|  |..|||.    |  .|  ......|     . .. | |  ..||||||| . |. ....    .|.  |    ||.   |.  
ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehl

RIQKPGSVQTVQQYQGIFQIV
| |.|| |.| .|.. ... |
rdqrpglvktkdqfefaltav
0041856 (Phosphotyrosine protein) phosphatases II 289-411 9.7e-14 46.8 In-house 72-170 (182) alignment 
Range on Protein: 289-411
Range on HMM: 72-170/182.0
NgyierkfevknnnTGATQSVTQYQITNWDLTGKLTnPQTILMVIEEMYRtqrkrGNTSIVVHCSDTVSRSAMFCAAATTINKckteGvIDVFQVLKSQR
              .  .. ..||. ..|.  |  . ....|  |||...      .  ..||||  |.|.....||   . .    | .......|  |
p.............ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvr

IQKPGSVQTVQQYQGIFQIVLTY
 ..||.|.| .||. . ...| .
srRpgmvitpnqyfflqlallel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 289-409 1.2e-09 32.8 In-house 141-256 (290) alignment 
Range on Protein: 289-409
Range on HMM: 141-256/290.0
NGYIERKFEVKNNNtGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMyrtqrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCK-TEGVIDVFQVLKSQ
.. ..|. .|| .. .    || ... .|. .    ...|.| .|. .     |  .| ..||| | .||||.. |      |   |.| . . .|||. 
ddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RIQKPGSVQTVQQYQGIFQIVL
| |.   ... ...  .   ..
rkqralaitsalelafvdagiv
0044763 (Phosphotyrosine protein) phosphatases II 289-408 1.7e-09 33.1 In-house 75-167 (178) alignment 
Range on Protein: 289-408
Range on HMM: 75-167/178.0
NgyierkfevknnntgatqsvTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKckteGViDVFQVLKSQR
.                     ||. ....  |  . .. .| ..| . . .  . .  ..||||  |.||....||   .      |. .......  |
g....................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

IQKPgSVQTVQQYQGIFQIV
 ..|  |..  |.. . .. 
erRp.ivpnpgqlrqLyefe
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 289-413 2e-09 31.7 In-house 151-278 (287) alignment 
Range on Protein: 289-413
Range on HMM: 151-278/287.0
NgYIERKFEVKNNNTGATQSVTQYQITNWdlTGKLTNPQ---TILMVIEE--MYRTQRK-RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQ
. |  | . . . .|  .. | |... .|    |   |     | .|..       .|.  .   .|||..  . || .. |  . ... .  | .|| .
e.ygvralrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaa

VLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
|.   | .. . ||.| |.. ... . ||  
vvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPRA_pd Subfamily PTPRA 290-412 1.4e-23 78.3 In-house 170-295 (330) alignment 
Range on Protein: 290-412
Range on HMM: 170-295/330.0
GYIERKFEVK----NNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNtSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLK
 |  ||| |.    . .  ... |.|.  | |   |  ..|. .| ..... ..... .. .||||||  | |.  |..  . ... |.|...|||...|
dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvk

SQRIQKPGSVQTVQQYQGIFQIVLTYL
. | |.|  ||| .||. |....| | 
rlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 290-410 1.6e-08 28.4 In-house 155-277 (439) alignment 
Range on Protein: 290-410
Range on HMM: 155-277/439.0
GYIERKFEVKNNN--TGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQ
 |. | | | |.   |   ..| |.. . |      ..   .|  .  .  .. |.    .|||||  | |.    |   .... |.|  .|.  ..|  
nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvl

RIQKPGSVQTVQQYQGIFQIVLT
| |.   ||.. ||  |.. || 
rkqrkqmvqalcqyvfiynavle
subfamily_PTPRG_pd Subfamily PTPRG 291-417 2.5e-18 60.6 In-house 161-292 (563) alignment 
Range on Protein: 291-417
Range on HMM: 161-292/563.0
YIERKFEVKN-----NNT-GATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVL
| .|.. .||     ..     . |.||. |.|  .|  . .   |. ..   .....     ||||||  |.|. ....  | ... ..| ...||..|
ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgfl

KSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
|  | |..  |||  ||. .....|  . | ||
khiraqRnflvqteEqYiflhdalleaiasket
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 291-401 2e-09 31.6 In-house 164-270 (301) alignment 
Range on Protein: 291-401
Range on HMM: 164-270/301.0
YIERKFEVKNNN-TGATQSVTQYQITNWDLTGkltNPQTILMVIEEMYRTqrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRI
 ..|..||..     ||..|| || ..|   |    |..   . . |     |. .  ||||||. . ||  | ..    .. ...  |.. . ||  | 
iskrtlevedstgkfatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlre

QKPGSVQTVQQY
..  .|||..| 
hrwngvqtnsql
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 292-411 2.6e-18 61.0 In-house 142-258 (267) alignment 
Range on Protein: 292-411
Range on HMM: 142-258/267.0
IERKFEVKNNNTGAtQSVTQYQITNWDLTGKltNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
    .|.| .|  | . || |   .|..  .  |   .  ..  . . | . ||  .||.||| | ||  |  . . ... ||||| |.|. |.  | |.
qiitlelkfknesa.hnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqr

PGSVQTVQQYQGIFQIVLTY
.| |.| ..|  | ...  |
iglvdtkeryiyihellaey
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 294-414 8.7e-15 49.0 In-house 265-387 (392) alignment 
Range on Protein: 294-414
Range on HMM: 265-387/392.0
RKFEVKNNNTGATQSVTQYQITNWDLTGKL--TNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
 |   . ... |. .|||||.  |   |    .  ...| .|  .  .  .. . ||.|||     |. .||.|   | .      .|.|| .|  | ..
skqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradr

PGSVQTVQQYQGIFQIVLTYLDS
  .||| ..|  .....  || .
mqfvqteeeyafvydvireylht
0048076 (Phosphotyrosine protein) phosphatases II 294-410 4.4e-13 44.6 In-house 32-141 (145) alignment 
Range on Protein: 294-410
Range on HMM: 32-141/145.0
RKFEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKrgNTSIVVHCSDTVSRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPG
. . . .. .. .. ..||. ..|.  |  . ....| ..| . . ...  .  ..||||  |.|.....||   .     .| ......|.  | | ||
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpg

SVQTVQQYQGIFQIVLT
.|....|.. ... .| 
avpnpgqlrflyefele
subfamily_CG7180_pd Subfamily CG7180 296-412 1.1e-17 58.6 In-house 169-290 (296) alignment 
Range on Protein: 296-412
Range on HMM: 169-290/296.0
FEVKNNNTGATQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRG-----NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQ
 | ... .  |  |...|.| |.|  |.    . |. . .. |. |..      .  .||..|| .||| ...|.  .... . |. .|||. .|  |..
teqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrs

KPGSVQTVQQYQGIFQIVLTYL
.|. |..|..|. |....| ..
RpqLvenveeYkyiYdvlleav
0043147 (Phosphotyrosine protein) phosphatases II 297-405 3.1e-15 51.8 In-house 53-154 (172) alignment 
Range on Protein: 297-405
Range on HMM: 53-154/172.0
EVKNNNTGATQSVTQYQITNWDLTGKLtNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSV
|  .. .. .... ||. ..|.  |   ... .| ..| ... . .. .  ..||||  |.|.....||   .        . .......  | ..||.|
ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgav

QTVQQYQGIF
|. .||. . 
qnpsqyrfly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 297-405 3.9e-08 27.1 In-house 176-281 (302) alignment 
Range on Protein: 297-405
Range on HMM: 176-281/302.0
EVKNNN--TGATQSVTQYQITNWDLTGKLTNPQTILMVIEemYRTQRKrgnTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGS
|.||..  .   ..|   . . |   |   ...| | ..   .    |   ....||||  | |.  . |    |. |... | |. ....  |  . |.
eiknekkkkkvkktvdilafsawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGa

VQTVQQYQGIF
||. ||   ..
vqdeqqliyll
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 298-412 1.2e-07 26.1 In-house 161-271 (288) alignment 
Range on Protein: 298-412
Range on HMM: 161-271/288.0
VKNNNTGATQS-VTQYQITNWDLTGKLTNPQTILMVIEEMyrtqrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
......| ..  | .  . .||  |   | .. | ..| .     |  .  ||||.|  | |.. .      ..  . .  . . ..|.. | ..  ..|
lriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiq

TVQQYQGIFQIVLTYL
| .||  ....|| .|
temqylyvhrcvleel
0046846 (Phosphotyrosine protein) phosphatases II 300-413 2.5e-12 42.4 In-house 77-174 (176) alignment 
Range on Protein: 300-413
Range on HMM: 77-174/176.0
NnntgatqsvtQYQITNWDLTGKLTNpQTILMVIEEMYRTQRKrGnTSIVVHCSDTVSRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
           ||. ..|.  |  .  . .| ..|.... ... |   ..||||  ..|.....||      ...|  ..|...|.  | |.| |.||| 
i..........qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

QQYQGIFQIVLTYLD
.||. . . .| .|.
eQyrflyefellllk
0048179 (Phosphotyrosine protein) phosphatases II 300-405 7.9e-12 40.6 In-house 48-138 (144) alignment 
Range on Protein: 300-405
Range on HMM: 48-138/144.0
NnntgatqsVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRkrGNTSIVVHCSDTVSRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQ
.        ..||. ..|.  |  . .. .| ..| . . ..   .  ..||||  |.|.....||   .    ..| ......|.  | . ||.|.. .
e........giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg

QYQGIF
|.. . 
qlrfLl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 300-419 8.7e-11 36.4 In-house 169-286 (307) alignment 
Range on Protein: 300-419
Range on HMM: 169-286/307.0
NNNTGATQSVTQYQITNWDLTGkltNPQTILMVIEEMYRTQRKrgNTSIVVHCSDTVSRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTV
 . .. .......| .||   |    ||. |  |. .  .. .  .  .|||||  | ||    | .   .|  . .   |. ....  | |.. ..|| 
vdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqte

QQYQGIFQIVLTYL-DSF-ETYS
 ||  . ...| |. . . ||| 
aqylylhrvlleyflelyketye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 302-413 1.9e-08 28.4 In-house 181-288 (305) alignment 
Range on Protein: 302-413
Range on HMM: 181-288/305.0
NTGATQSVTQYQITNWDLTGKltnPQTILMVIEEMYRTQRKRGntSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVQQ
  . .. ||.|   .|   |    | . | ..| . ...  .|   ||||||  . |.         ...  .  .|.   ..|.  | |.  |.|| .|
pgekarkvthyhwidwpdrgv...paadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq

YQGIFQIVLTYLD
|  . |..| |. 
ylfvhqvilnyfr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 304-410 8.3e-17 56.1 In-house 172-277 (315) alignment 
Range on Protein: 304-410
Range on HMM: 172-277/315.0
GATQSVTQYQITNWDlTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQG
   . | |...| |  . ....  . || .    .  ..   ..||||||. | |.  |..  . ... ..| .|||.....  | .. . ||...||| 
dnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqf

IFQIVLT
|....| 
iydalle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 304-411 1.3e-07 25.6 In-house 164-268 (281) alignment 
Range on Protein: 304-411
Range on HMM: 164-268/281.0
GATQSVTQYQITNWDltgKLTNPQTIlMVIEEMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVQQY
| |. .|..   .|        |..   |. .. |  | |  |  |.|||  | ||  . |   ...  ..   . |. |..   |.  .  ||||.|||
getrlithwlwkewp...dwqvpess.evmlkilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqy

QGIFQIVLTY
  |....| .
mliwkvlldf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 304-412 4.3e-06 20.6 In-house 185-289 (305) alignment 
Range on Protein: 304-412
Range on HMM: 185-289/305.0
GATQSVTQYQITNWDLTGKltnPQTILMVIEEMYRTqRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQ
. . || . | |.|   |    |   |  .| .    |   .  ||||||  . |.    |    ..|   .  .  . ...|. | |.  |.|.  || 
dqkmsvrhlqwtewpdrgv...ppckltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqyl

GIFQIVLTYL
 | ...| |.
fihrvmlnyf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 304-412 6e-06 20.5 In-house 113-221 (255) alignment 
Range on Protein: 304-412
Range on HMM: 113-221/255.0
GATQSVTQYQITNWDLTGKLTNPQTILMVieemYRTQRKRgnTSIVVHCSDTVSRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
  |. |. |. . |       ... || .    ..  |.    |.|||||  . ||| |  |            . .| . .|  ..|.  | .......
kkthtvkhysykGWieknaPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraih

TVQQYQGIFQIVLTYL
|  |    . .||...
tPlqlafsilmvldlv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 306-412 4.9e-13 43.2 In-house 88-194 (440) alignment 
Range on Protein: 306-412
Range on HMM: 88-194/440.0
TQSVTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
.... ||.   |   |       .| .|...  .| | ||  ..||||  ..|...  |  . . ..|    ||.| ...| | ..|  ||| .||  ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QIVLTYL
. ||  |
eavlegl
0051082 (Phosphotyrosine protein) phosphatases II 307-406 1.3e-11 39.8 In-house 58-147 (151) alignment 
Range on Protein: 307-406
Range on HMM: 58-147/151.0
QSVTQYQITNWDLTGKLTNPQTILMVIEEMYRtqrkRGNTSIVVHCSDTVSRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
  |....|..|. .|  ......| ..|.. .     .|  ..||||  ..|.....|.   . .      ......|.  |.. ||.||. ||.. ...
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
PTPc_DSPc_SM00012 309-408 1.6e-21 71.9 In-house 2-103 (105) alignment 
Range on Protein: 309-408
Range on HMM: 2-103/105.0
VTQYQITNWDLTGKLTNPQTILMVIEEMYRTQRKRG-NTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
|..|..|.|  .|. .... || ..... . ..|.. ....|||||. |.|...|.|... ......| . .|.||..|. | |.||.||| .||. . .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IV
..
al
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 312-412 6e-09 29.7 In-house 186-285 (302) alignment 
Range on Protein: 312-412
Range on HMM: 186-285/302.0
YQITNWDLTGKLTNPQTILMVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
| .|||  .  ...  ..   .....  .   .. ..|.     . | ..| ..|....| ...    . ...|| | |.| .|....||  .. ..|.|
yvltnWkqkkvpvkyaeliktaakvfakk.ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

L
.
i
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 323-412 2.2e-07 23.8 In-house 218-309 (346) alignment 
Range on Protein: 323-412
Range on HMM: 218-309/346.0
LTNPQTILMVIEEM--YRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
| .|   | .|  .  . ....  |. . |       |.  |  |  .||.       ......|. . |.||.|..  || .|. ||. |.
lqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 335-411 7.4e-10 33.2 In-house 219-294 (297) alignment 
Range on Protein: 335-411
Range on HMM: 219-294/297.0
EMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
| .|..  | |. ..||||  | || .   . . ..| . . . ||  .|.  | |..  |||..|.. ....||  
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_egg_pd Subfamily egg 338-412 8.2e-06 19.7 In-house 195-270 (307) alignment 
Range on Protein: 338-412
Range on HMM: 195-270/307.0
RTQRKrGNTSIVVHCSDTVSRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVQQYQGIFQIVLTYL
|  |.   . .||.. . ||..| . |. ... .    | |  . ||..    | ... ||..| .|  ....|| ..
rklrn.lskpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_CG42327_pd Subfamily CG42327 339-411 5.4e-08 26.9 In-house 241-314 (319) alignment 
Range on Protein: 339-411
Range on HMM: 241-314/319.0
TQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
. ..  .  .|||||| | |. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey