Gene PTPRD-30 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP085_AA protein Get Run
AqueP085_AA_1-232 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-240 4.1e-137 450.9 In-house 48-287 (287) alignment 
Range on Protein: 1-240
Range on HMM: 48-287/287.0
NDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSpLVIGEYNIT
.||||.||.|.|.|.||.||.|||||||||||.||||||||||||||||||||||||.|||||||||||||.|.||.|||||||||.. | .|.|||||.
kdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeynie

LSSEETCNGYIERKFEVKNTN-TAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDV
| .||. .||||||.||||.| ....|.|.||||||||||||.|.||||||||||||.||||||||||||||| || |||||||||||||||||||||||
llneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDv

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSNF
||||||||||||||||||.||..|..|||.|||||||||.|
fqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-238 1.5e-122 403.0 In-house 48-290 (290) alignment 
Range on Protein: 2-238
Range on HMM: 48-290/290.0
DKNRSTQFLPPNNHRVPLK--NEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLvIG
 .||..........|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.|....||.||||....|.....|.||||....   .|
llnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.yg

EYNITLSSEETCNGYIERKFEVKNTNT-AATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTE
|..|.|..|||.|.|||||.||||.|. .|.||||||||||||||||.||||||||||||||.|||||||||||||||.||.|||.||||||||||||||
efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckte

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
||||||||||||||||||||||||||||||||||||||||||||
gvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
0050432 (Phosphotyrosine protein) phosphatases II 2-239 1.1e-70 233.8 In-house 70-307 (308) alignment 
Range on Protein: 2-239
Range on HMM: 70-307/308.0
DKNRSTQFLPPNNHRVPLkNEHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST--PSPLVIGEY
||||.. .||  . || | .|. ||||| ...||  | ...||.. .|. ||  .||.|. . ||. ||||. . ||. | |.||||..   ..|..| .
dkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkf

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQrkrGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 .|| |||....|. |..|..|...  .  ||... |||   |  ..|. .|  .|.. ...   ..  ||||||  |.|.. |.|. . ..  ..|| .
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
|||...|  | |.||.|||..||. .....| || ...|. |
dvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
0036941 (Phosphotyrosine protein) phosphatases II 2-237 3.5e-69 228.7 In-house 41-283 (297) alignment 
Range on Protein: 2-237
Range on HMM: 41-283/297.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGEYNIT
.|||.. .|| .. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||| ||||. . |.. | |.||||.. ...|. |.. .|
eknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvt

LSSEET--CNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSGTVSRSAMFCAAATTINKCK---TE
| |.|.  ...|. |..||..|..  .  ||....|.|.  |  ..|...|  ||.. . ...  ... ..||||. |.||..|.|| . ..  .   .|
llsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklke

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
| .|.....|. | |.||.|||..||. . ...| .| ...|.
ggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0046845 (Phosphotyrosine protein) phosphatases II 2-239 4.1e-69 228.4 In-house 30-282 (284) alignment 
Range on Protein: 2-239
Range on HMM: 30-282/284.0
DKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSP
.|||....|| .. || ||.     |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||. ||||. . ||. | |.||||.. ..
sknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

LVIGEYNITLSSEETCNGYIERKFEVKNTN-TAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSGTVSRSAMFCAAATTIN
|..|.. .|| |||....|. |..|..|.. |  .  ||....|.|   |  ..|. .|  .... . ...  |.  ||||||. |.|...|.|. . ..
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllle

KCKTEG---VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
  ..||   ..||....|  | |.||.|||..||. .....| || .. |. .
qlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0051299 (Phosphotyrosine protein) phosphatases II 2-231 5.5e-68 224.8 In-house 51-286 (288) alignment 
Range on Protein: 2-231
Range on HMM: 51-286/288.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStPSPLVIGEY
.|||.. .|| .. || |..    |. ||||| .|.||. |..||... |. ||  .||.|. . ||. ||||. . |.. | |.||||.  ..|..|..
eknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygdi

NITLSSEETCNGYIERKFEVKNT----NTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSGTVSRSAMFCAAATTINKCKT
 .|| |||....|. |..||.|.     .  .. ||... |||   |  ..|. .|  ...... ..  |.  .|||||  |.|...|.|. . ..  ..
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
||..||....|  | |.||.|||..||. .....| ||
eggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 2-231 8.4e-68 224.1 In-house 40-272 (273) alignment 
Range on Protein: 2-231
Range on HMM: 40-272/273.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPS--PLVIGEYNI
||||.. .|| .. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. ||||. . |.. | |.||||..    .|. |.. .
dknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftv

TLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVID
|| ||||...|. |..|..|..|  .  ||... |.|   |  .... .|  ||.. .....  .|. .|||||. |.|...|.|. . ..  ..|| .|
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|....|  | |.||.|||..||. . ...| ||
vleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 2-237 2e-67 223.1 In-house 50-287 (564) alignment 
Range on Protein: 2-237
Range on HMM: 50-287/564.0
DKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTpSPLVIGEY
 |||  . .. .. || |.    .|  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .|.... | .|||.. ..  .||.
aKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gtetygel

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 .||..||. . |. |.|..|....  .. |.|.. |.| ..| .......| .|... ... ....  ||||||  | |. .|..    ... |.|...
tVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
|..|..|  | |..  ||| .||. |....| .|....| 
DiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0040438 (Phosphotyrosine protein) phosphatases II 2-237 1.6e-66 220.1 In-house 45-282 (317) alignment 
Range on Protein: 2-237
Range on HMM: 45-282/317.0
DKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStPSPLVIGEY
||||.. .||  . || |...      ||||| ...|...|..||.. .|. ||  .||.|. . .|| ||||... |.. | |.||||.  ..|..|..
dknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdf

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 .|| |||...|.. |..||.....  .  ||... |.|.  |   .|...|  .|.. . .. .... ..||||. |.|...|.|| . .. ...|| .
tvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
||....|  | |.||.||| .||. . ...| ||  ..|.
dveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0045450 (Phosphotyrosine protein) phosphatases II 2-231 2.8e-65 216.4 In-house 57-304 (307) alignment 
Range on Protein: 2-231
Range on HMM: 57-304/307.0
DKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFI--------NGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST
||||.. .|| ...|| |..     |. ||||| ..        .||. |..||.. .|. .|  .||.|. . .||.||||... |.. | |.||||..
dknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde

PSPLVIGEYNITLSSEETCNGYIERKFEVKNT-NTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSGTVSRSAMFCAAAT
 ..|..|.. .|| |||...||. |..||...  |  .  ||... |.|  .|  ......|  |||. . ...  ... ..||||. |.|...|.|| .
geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 .   ..||.   .|.....|  | |.||.||. .||. . ...| .|
mlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-238 2.9e-64 212.2 In-house 58-297 (298) alignment 
Range on Protein: 2-238
Range on HMM: 58-297/298.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSpLVIGEY
.||| .. .. .  || |..    |. |||||.|...||...|||... |. .|  .||.|. ......||||   .| ..  . .|||.. .    || 
kkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygei

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
...| |.|.   .| ||..|...... ...| | . |.| . |  .| ...| ..... ..|.. ||....|.||  | ||  |.|  . ... |.| |.
tvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
|||||.|  |...||.||| .||  |...|| .||||... 
DvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
Y_phosphatase Protein-tyrosine phosphatase 2-228 1e-63 210.3 Pfam-A 3-234 (235) alignment 
Range on Protein: 2-228
Range on HMM: 3-234/235.0
DKNRSTQFLPPNNHRVPL--KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWP-STPSPLVIGEYN
.|||....|| .. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ..  .|  |...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

ITLS-SEE-TCNGYIERKFEVKNTNTA-ATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
..|  .|.  ...|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||  |.|...|.|. . ......|.
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaee

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 .||.|..|. | |.||.||...||. . ...|
evdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2-228 1e-63 210.3 In-house 3-234 (235) alignment 
Range on Protein: 2-228
Range on HMM: 3-234/235.0
DKNRSTQFLPPNNHRVPL--KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWP-STPSPLVIGEYN
.|||....|| .. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ..  .|  |...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

ITLS-SEE-TCNGYIERKFEVKNTNTA-ATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
..|  .|.  ...|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||  |.|...|.|. . ......|.
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaee

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 .||.|..|. | |.||.||...||. . ...|
evdvlqivkelRkqRpgmvqsleqYiflykail
DSPc_SM00195 2-231 1.4e-63 210.1 In-house 28-262 (263) alignment 
Range on Protein: 2-231
Range on HMM: 28-262/263.0
DKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGE
.|||....|| .. || ||.|.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||. |.||..| |..|||..  .. ..|.
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgk

YNITLSSEETCN-GYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
....| ..|...  .| |..|......  |..|||||..||   |   ... .| ...... ....  .. ||||||  |.|...|... . ..|...| 
isvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeek

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 .|.|...|. | |.||.||| .||. | ...| |.
kvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2-231 1.4e-63 210.1 In-house 28-262 (263) alignment 
Range on Protein: 2-231
Range on HMM: 28-262/263.0
DKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGE
.|||....|| .. || ||.|.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||. |.||..| |..|||..  .. ..|.
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgk

YNITLSSEETCN-GYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
....| ..|...  .| |..|......  |..|||||..||   |   ... .| ...... ....  .. ||||||  |.|...|... . ..|...| 
isvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeek

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 .|.|...|. | |.||.||| .||. | ...| |.
kvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 2-231 1.7e-62 206.8 In-house 47-277 (278) alignment 
Range on Protein: 2-231
Range on HMM: 47-277/278.0
DKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPstPSPLVIGEY
||||.. .|| ...|| |...      ||||| ...||. ...||..  |. .|  .||.|. . .|| ||||. . |.. . |.||||   ..|..|..
dknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdf

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 .|| .||....|. |..||.|. .  .. ||.|. ..|   |  ......|  .... . ..   |. ..||||. |.|...|.|. . ..  ..|| .
tvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|.....|  | |.||.||| .||. .....| ||
dleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-239 1.8e-62 206.3 In-house 48-288 (318) alignment 
Range on Protein: 2-239
Range on HMM: 48-288/318.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTpSPLVIGEY
 ||| .  |. .. || |..    |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| . |||| .|.|.  . . .||||   .  .|. 
aknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.gsrsygkl

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 ..|..| ... |. |.|.|..|.. ... | ||..|.|  .|  ... ..| .. .  ..|.| |.. ||||||. | |  .|.|  . ... | |...
vvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
||||. |  | |..  ||| .||. |....| .| |..|. .
Dvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0039614 (Phosphotyrosine protein) phosphatases II 2-235 3.3e-62 206.0 In-house 58-293 (297) alignment 
Range on Protein: 2-235
Range on HMM: 58-293/297.0
DKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEeVCYQYWPSTPSplVIG
||||.. .|| ...|| ||      .. ||||| ...||.  ...||..  |. .|  .||.|. . .||.||||. ..|..   |.||||.. .  . |
dknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tyg

EYNITLSSEETCNGYIERKFEVKNtnTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSGTVSRSAMFCAAATTINKCKTE
.. .|| ..|...||. |..||.|  .  .  ||..| |.|   |   .....| ..|.. . ...  ... ..||||. |.|...|.|| . .. ...|
dftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
| .||....|  | |.||.||| .||. .....| .|  . 
ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0042113 (Phosphotyrosine protein) phosphatases II 2-231 2e-60 199.6 In-house 11-243 (245) alignment 
Range on Protein: 2-231
Range on HMM: 11-243/245.0
DKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStPSPLVIGEY
||||....|| .. || |...      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | |.. . |.||||.  ..|..|..
dknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdf

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 .|| |||....|. |..||.|. .  .. |..|. ..|.  |  ......| ..|.. . ... .|. ..||||. |.|...|.|| . ..  ..|. .
tvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
......|  | |.||.||| .||. . ...| .|
sleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-229 2.6e-60 198.7 In-house 35-264 (283) alignment 
Range on Protein: 2-229
Range on HMM: 35-264/283.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSpLVIGEYN
 |||  . .| ...|| ||.| .||||||||     ||..| .||| ||. .| ..||||. |...|||||| .  |.... | ||||.  |    ||. 
rknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs.edyGeft

ITLSSEETCNGYIERKFEVKNT-NTAATQSVTQYQITNWDSTGKMTNPQTiLLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
.||  | | | .| ... ...   . .|  .. ||. .| . |. .   . |. .. .   |..  .. |||||| .. |.|.|.||...... .|| |.
vtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
|||.|.|  | |... ||| .||. . ..|| 
dvfavvkimreqrmmavqtldqyklvhelvle
0040439 (Phosphotyrosine protein) phosphatases II 2-231 9.7e-60 197.6 In-house 13-246 (249) alignment 
Range on Protein: 2-231
Range on HMM: 13-246/249.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStPSPLVIGEY
||||.. .||....|| |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... |.. | |.||||.  ..|..|..
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdf

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGV
 .|| |.|....|. |..|..|. .  .  |...|.|.|  .|   .....|  ||..   ...   .. ..||||. |.|...|.|| . ..  ..|. 
tvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|.....|  | |.||.||. .||. . ...| .|
vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-239 1.6e-59 196.2 In-house 11-250 (250) alignment 
Range on Protein: 2-239
Range on HMM: 11-250/250.0
DKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEvCYQYWPSTpSPLVIGEY
.||| ..... .. || |..|.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   .|.... . ||||    .   |. 
eknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve.kaekyGdv

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 ..| |.|.   |. ||. . ... |  . | |.. ..|   |   . ...| ..... ..|.. ||. ..|.||  |.||  |.|  . ... |.| |.
tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
|||.|.|  |...|..|.. .||  ...|.| .|||.| |..
dvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
0045098 (Phosphotyrosine protein) phosphatases II 2-232 2.4e-59 196.3 In-house 35-273 (278) alignment 
Range on Protein: 2-232
Range on HMM: 35-273/278.0
DKNRSTQFLPPNNHRVPlknehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStPSPLVIGEYNITL
|||| ...|| .. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... |.. | |.||||.  ..|..|.. .||
dknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtl

SSEETCNGYIERKFEVKNT----NTAATQSVTQYQITNWDSTGKMTNP--QTILLVIEEMYRTQR------------KRGNTSIVVHCSGTVSRSAMFCA
 |||... |. |...| |.    ..  .  ||......|.  |  ..|  . .| ..|.. . ..              ... ..||||  |.|.....|
lseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

AATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTYLD
| . .  .  ||..|.....|  | |.|| .||. .||. ... .| .| 
aylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRA_pd Subfamily PTPRA 2-231 3.6e-56 185.4 In-house 60-295 (330) alignment 
Range on Protein: 2-231
Range on HMM: 60-295/330.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSpLVIGEY
.|||  . || .  || | .    |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .| .|| |.||||.  . .  |. 
eknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGni

NITLSSEETCNGYIERKFEVK----NTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNtSIVVHCSGTVSRSAMFCAAATTINKCKT
....  |. .. |  ||| |.    .|.  ... |.|.  | |   |  ..|. .| ..... ..... .. .||||||  | |.  |..  . ... |.
rvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervka

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|...|||...|. | |.|  ||| .||. |....| | 
erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-236 6.2e-56 184.8 In-house 50-288 (319) alignment 
Range on Protein: 2-236
Range on HMM: 50-288/319.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTpSPLVIGEY
.||| .. |. .. || |..    |  ||||| ||.||.|...|| . .|. ||  .||.|. ....  .|||.. .|. .  . .|||..  . . |..
kknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrl

NITLSSEETCNGYIERKFEVKNTNTAA-TQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGV
 .|| .||  ..|| ||..... ..   | .|...| |.|   .  .. ...| ..... ....|  .  ||||||  | |   |..   .... | |||
ivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegv

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
.|||.. .  |.|..  ||. .||. |....| ......|
lDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0037934 (Phosphotyrosine protein) phosphatases II 2-230 8.9e-53 174.7 In-house 12-241 (243) alignment 
Range on Protein: 2-230
Range on HMM: 12-241/243.0
DKNRSTQFLPPNNHRVPLKNehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENENNEEVCYQYWPstPSPlVIGEY
.||| . .|| .. || |..   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... |.. | |.||||   .  ..|..
sknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.tygdf

NITLSSEETCNGYIERKFEVKNTN-TAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSGTVSRSAMFCAAATTIN
 .|| |||....|. |.....|.. .  |. |..|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||. |.|.....|| . . 
tvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll

KCkteGvIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTY
..   | .|.....|  | |.|| .||| .||. . ...| .
ll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 2-236 1e-50 167.5 In-house 49-292 (563) alignment 
Range on Protein: 2-236
Range on HMM: 49-292/563.0
DKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStPSPLVIGE
 ||| .. .. .. || |..     .. ||||| .|.||. .||||..  |. .|.  ||.|| ..||. |||.   .|.. . | .|||.   .. .|.
rKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetyga

YNITLSSEETCNGYIERKFEVKNTNTAATQS------VTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrGNTSIVVHCSGTVSRSAMFCAAATTINK
 ..|| .||.   | .|.. .||..  ....      |.||. |.|  .|  . .   |  ..   .....     ||||||  |.|. ....  | ...
lqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkq

CKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
 ..| ...||..||  | |..  |||  ||. .....|  . | ||
iqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_PTPRB_pd Subfamily PTPRB 2-233 2.4e-50 166.2 In-house 53-287 (293) alignment 
Range on Protein: 2-233
Range on HMM: 53-287/293.0
DKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEY
.||| |. || .. || |    .... ||||| .|.||. .. || .  |. .|  .||.|. ......|||| .  |.  . | .|||.. .| . |. 
aknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdi

NITLSSEETCNGYIERKFEVKNtnTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQ-RKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGV
..|| .||. . .. |......  . ....|.||. | |   |   ...|.|  .... ... ..  .. ||||||  | |.  | |  . ... ..| .
kvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedy

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.|.| .. . | ..   |||..||  | | ||..| .
vdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-236 1.3e-49 163.9 In-house 53-289 (297) alignment 
Range on Protein: 2-236
Range on HMM: 53-289/297.0
DKNRSTQFLPPNNHRVPLK--NEH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEeVCYQYWPSTPSPLvIGEY
.|.| .  || .  || |.  |..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..||...  | .||. . .    |. 
eksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdv

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
 ..|.| . ..|.|.|..||.. .. |.. | ||| ..| .       . ...| .|.|.  .  .. .. ..|||.  | | .....    . . | | 
svvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrek

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
 .|.|...|  | ..|  ||| .||. ....|| .| | .|
evdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-235 3.1e-49 162.6 In-house 49-285 (288) alignment 
Range on Protein: 2-235
Range on HMM: 49-285/288.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEY
.|||  . || . .|| ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... ..... |||| .  |.... | .|||..  |   |. 
kknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsv

NITLSSEETCNGYIERKFEVKntNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
..|| .... . ...||....   .     .|||| . |  .|   . . .| ... .  .. .     |.||||  | |.  | |. . |.. ..| .|
tvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyi

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL--DSFE
||. ...  | |..  |||..||. |....|.    |. .
DvagtvaklRkqRallvqtlkqYefiyevllslieedgva
subfamily_PTPN23_pd Subfamily PTPN23 2-231 6.8e-49 161.2 In-house 45-280 (288) alignment 
Range on Protein: 2-231
Range on HMM: 45-280/288.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGEYNI
.||||.  || .. || |.... ||||| |...       ||.. .|. .|.  ||.|. .. .  |||| ...| ... . .|||.    . . |....
eknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsv

TLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVI---EEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCK-TEG
||.|... . ..||.....  .. |..||.  |.|.| . |    |.|.| ..   |..|...... .| .|||||  | |. .|.   . ... .  .|
tlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgng

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
..|. ||..  | |.  .||...|..  ...||.. 
lldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-232 7.3e-49 161.2 In-house 45-277 (515) alignment 
Range on Protein: 2-232
Range on HMM: 45-277/515.0
DKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLV-IGE
 |||    || .. || |     | | ||.|| .|....  ||.| .  |   .  .||... . |||.|.|. . .|..   | .|||  |.  |  |.
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

YNITLSSEETCNGYIERKFEVKNTNTaaTQSVTQYQITNWDSTGKMTNPQTILLVIEEMyRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGV
... | | |.| | | ||..|   .   .. |||.. |.|   |   . ...| .| |. .... . . ....|||  | |  .....   . . ||  .
ikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrm

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.|||....  | ..|  ||| .||  |...|| .| 
vdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-232 8.2e-49 161.1 In-house 46-278 (315) alignment 
Range on Protein: 2-232
Range on HMM: 46-278/315.0
DKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPS-PLVIGE
 |||    || .. || |    .. . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|..   | ||||   .     |.
kknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGs

YNITLSSEETCNGYIERKFEVKNTNTaaTQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGV
....| | |.. . . ||. ......  .. |||.| |.|   |   .  ..| .| |.    ... . |..||||  | |. .....   ... | . .
ikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrs

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.|||...|  | ..|  ||| ..|  |...|| .| 
vdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN12_pd Subfamily PTPN12 2-231 1.6e-48 160.1 In-house 42-277 (290) alignment 
Range on Protein: 2-231
Range on HMM: 42-277/290.0
DKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGE
 |||    || .. || |.    .|. ||||| ||.| ..|...| | .|. .|  .||.||.. ||. .||.|.| |..   | .|||..  ..| .||
kknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefge

YNITLSSEETCN-GYIERKFEVKNTntAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
...||..|.... ... | ..|..    ....|.|.. |.|   |  ......| .||.. ..|. . .. .|||||  | |    .|   . .  |.| 
fevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaek

V---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.   .|||... . | |..  ||| .||. ... |. ..
ipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPRK_pd Subfamily PTPRK 2-229 1.7e-48 160.1 In-house 45-275 (314) alignment 
Range on Protein: 2-229
Range on HMM: 45-275/314.0
DKNRSTQFLPPNNHRVPLKN---E-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPlvIGEY
.||||.. |.....|| |.    . . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  |.    |..|||   .    |. 
eknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdi

NITLSSEETCNGYIERKFEVKN--TNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
...| . |. . .. | | |..   .  ... | |.| ..| . .  .. ...| .. ..  .| . ..  ||||||    |. .|.| .. ..  ..||
kvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmiereg

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
|.|||.. |. | .|.  |.| .||. |....| 
vvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-232 1.6e-46 153.6 In-house 30-269 (274) alignment 
Range on Protein: 2-232
Range on HMM: 30-269/274.0
DKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIG
 ||| .. || .| || |..     |  .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .|.||. | .|.| . .  . .
tknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeise

EY---NITLSSEETCNGYIERKFEVKNTNTaaTQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNT--SIVVHCSGTVSRSAMFCAAATTINK
.|   .|. ..  ..|.|  ||. .|...   ..||. |  |.|  .    ...|.| ...|. ...... .   ..|||||  . |  .| |.  ....
rygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrq

CKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
 . |.|.||...    |... | ||| .||. |....  || 
lreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-229 1.1e-45 151.3 In-house 63-289 (319) alignment 
Range on Protein: 2-229
Range on HMM: 63-289/319.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennEEVCYQYWPSTPSpLVIGEY
|||| .. |. .. .| |..    |  ||||| |..||. |. .| |  |. ||  .||.|| . |...||.|       .. | ||||        ...
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerf

NITLSSEETCNGYIERKFEVKN-TNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
.. ..| | .. |. |..|. . ..    ...||. .  |   |.   |  .. ...   . |........||||||  | |. .. .  . ... | | 
kvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeek

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 .||.....  | |..  || . ||. |.  .| 
qvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-229 1.7e-45 150.7 In-house 27-253 (284) alignment 
Range on Protein: 2-229
Range on HMM: 27-253/284.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennEEVCYQYWPSTPSpLVIGEY
|||| .. |. .. .| |..    |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||        ...
dknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerf

NITLSSEETCNGYIERKFEVKN-TNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG
.. ..| | .. |. |..|. . ..    ....|. .  |   |.   |  .. ...   . |........||||||  | |. .. .  . ... | | 
kvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeek

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 .||.....  | |..  || . ||. |.  .| 
qvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-233 2.1e-45 150.3 In-house 50-290 (325) alignment 
Range on Protein: 2-233
Range on HMM: 50-290/325.0
DKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAIVMLCHENENNEEVCYQYWPST-PSPLVIGE
.|||    .. .. || |.    . . ||||| ... .|.|. |. | .|. .|  ..|... | . ...|..  | ..... | .|||         | 
aknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGg

YNITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVI---EEMYRTQR--KRGNTSIVVHCSGTVSRSAMFCAAATTINKC
 .. | . |.   |. |...||...   |.|| |.|.  ||  |    | |.. ..   ...  . .   .. | |.||||  | |. .| .  . ..| 
levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakv

KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
 .|  .|.|...|  | ..|  |.|| ||  |.. .  .. |
ieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_PTPN6_pd Subfamily PTPN6 2-235 2.3e-44 146.6 In-house 56-301 (306) alignment 
Range on Protein: 2-235
Range on HMM: 56-301/306.0
DKNRSTQFLPPNNHRVPLKNE---HPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGE
 |||    || .. || ||..     ||||| .|..   ...|..| ..  . .|  .||.|. . | . |||. .|.| ..| |..|||.. .    |.
eknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGk

YNITLSSEETCNGYIERKFEVK-NTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG---NTSIVVHCSGTVSRSAMFCAAATTINKCK
...|  ||.. . || |.. |. ...   ...| ||. ..|   |  ..|...|  .|.. | |..     . .||||||  . |   |    . ... .
isvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie

TEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
..|.   ||. .. || | |. | ||| |||. ..... .|... .
kkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-229 4.2e-44 145.8 In-house 51-277 (315) alignment 
Range on Protein: 2-229
Range on HMM: 51-277/315.0
DKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTpsPLVIGEY
.|||  . .. .. || |    ...| ||.|| ||.||. |. .| |..|  .. ..||... . ... ||||    |.... . .|||     .. |..
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGki

NITLSSEETCNGYIERKFEVknTNTAATQSVTQYQITNWDsTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
 .|. |||  . |  | . |  .     . | |...| |  . ....  . |. .    .  ..   ..||||||  | |.  |..  . ... ..| .|
tvtrkseevnteytvrtlsv..vfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenai

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
||.....  | .. . ||...||| |....| 
dvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN3_pd Subfamily PTPN3 2-228 9.5e-44 144.4 In-house 43-272 (280) alignment 
Range on Protein: 2-228
Range on HMM: 43-272/280.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEY
.|||    || .. || ||... ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |.    |.||||.|   |  ||.
sknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygef

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMyRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
......|.. . |. |.. .|...|   ....| | ..|   |  .... .| ..|.. |..|.  .. .|||||. . |. .. .  |.. .  ..  .
svkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 . ....  | |.   |||..||. . . .|
ypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN9_pd Subfamily PTPN9 2-231 1.2e-41 137.7 In-house 44-290 (297) alignment 
Range on Protein: 2-231
Range on HMM: 44-290/297.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWP-STPSPLVIGE
 ||| |  |  .. || |..    |. ||||| |..|||.||||| .  |. .| ..||.|. ...|  |||  .  |.    | |||| .. |    |.
eknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgd

YNITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQR---------KRG---NTSIVVHCSGTVSRSAMFCAA
....  . |. . | .|..|.||..|  ...|| .|.. |   |   . ...| |.|.. ..|          ..|   .  ||||||  . |.  |.. 
lsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitl

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
  .... ...|..||....|  | |.  |.|| .||.  .. || | 
diclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_CG7180_pd Subfamily CG7180 2-231 1.7e-41 136.8 In-house 44-290 (296) alignment 
Range on Protein: 2-231
Range on HMM: 44-290/296.0
DKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEeVCYQYWPSTPsPLVIGEY
.|||  . .|... || |.    .|. ||||||.....  ||..|. | |. .|  .||... |... |.|.|... . ..  . .||| .      || 
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygei

NITLSSEETCNGYIERKFEVKNT----------NTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG-----NTSIVVHCSGTVSRSAMFC
 . . .|..      |.| .. .           .| |  |...|.| |..  |.    . |. . .. |. |..      .  .||..|  .||| ...
fveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyl

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|.  .... . |. .|||. .|  |...|. |..|..|. |....| ..
aidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPN13_pd Subfamily PTPN13 2-233 4.7e-40 132.6 In-house 39-271 (273) alignment 
Range on Protein: 2-233
Range on HMM: 39-271/273.0
DKNRSTQFLPPNNHRVPLKNEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGE-Y
||||  . || .. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .| |...  | .|||..  ..|.. . .
dknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrl

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkrGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
...|   .  .|.  |...||........ |.. . ..|   |  .... .| .. |. | |.   .. ||||||  . || .. .  . ..  . .  .
evellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkef

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
|| ..... | |. | ||| .||  .....|. | |
dvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-232 2e-39 130.1 In-house 40-278 (287) alignment 
Range on Protein: 2-232
Range on HMM: 40-278/287.0
DKNRSTQFLPPNNHRVPLKNEH---PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYN
 ||| .. || .. || | .|     ||||| .. .|....||| | .|.  | |.||... .......... .| |.    ||.|||    |. .| | 
kknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGys

ITLSSEE-TCNGYIERKFEVKNTNTAATQSVTQYQITNWdsTGKMTNPQ---TILLVIE--EMYRTQRK-RGNTSIVVHCSGTVSRSAMFCAAATTINKC
..| . .     |  | . . . .|  .. | |... .|    |   |     | .|..  .    .|.  .   .|||..  . || .. |  . ... 
vvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl

KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.  | .|| .|.   | .. . ||.| |.. ... . ||  
edlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2-230 7e-39 128.4 In-house 35-258 (267) alignment 
Range on Protein: 2-230
Range on HMM: 35-258/267.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNeeVCyQYWPST-PSPLVIGEYNIT
..||  . || .. ||.|...  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| .  ..|  .  ..||          .  . 
ernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..ir.lfwPPkmgqakkyqdltve

LSSEETCNGYIERKFEVKNTNTAAtQSVTQYQITNWDSTGKmtNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVF
 | |.  | |    .|.|  | .| . || |   .|.   .  |   .  ..  . . | . ||  .||.||  | ||  |  . . ... ||||| |.|
hslekeendyqiitlelkfknesa.hnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdif

QVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
. |.  | |..| |.| ..|  | ...  |
dflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN1_pd Subfamily PTPN1 2-227 8.3e-39 128.0 In-house 34-267 (290) alignment 
Range on Protein: 2-227
Range on HMM: 34-267/290.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPS--PLVIG--EY
..||     | .  |. |.... ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  |...  |.||||.  .   |..   ..
nlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtkl

NITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQR-KRGNTSIVVHCSGTVSRSAMFCAAATTIN---KCKT
...| |||. . |. |..|..| .|  |......  | |   |    |.. |  . .. ..   ..     |.|||  . ||  || . | .    | . 
kvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkdd

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
   .|. .||   | .. | .|| .| .  .. .
lssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPRN_pd Subfamily PTPRN 2-227 4.1e-38 125.8 In-house 58-288 (297) alignment 
Range on Protein: 2-227
Range on HMM: 58-288/297.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPlVIGE
.||||...|| .. || ||.    |. ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.. .|.. . |..||| . |  | . 
kknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.vyhi

YNITLSSEET-CNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGnTSIVVHCSGTVSRSAMFCAAATTINKC-KTE
|.. | ||   |. |. | | .|| .|  |..|||.    | ..|  ......|     . .. | |  ..||||||. . |. ....    .|.  |  
yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGv

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
  ||.   |.  | |.|| |.| .|.. ... |
keidiaatlehlrdqrpglvktkdqfefaltav
subfamily_PTPN14_pd Subfamily PTPN14 2-232 3.5e-35 116.4 In-house 51-297 (300) alignment 
Range on Protein: 2-232
Range on HMM: 51-297/300.0
DKNRSTQFLPPNNHRVPL---KNEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST---PSPLV
.|||  ..|| .. || |   |... .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| .|.|.  | ...|.|..    . . 
eknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktve

IGEYNITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNT--------SIVVHCSGTVSRSAMFCAAA
 |....|    |. . .| .....|   .   ..|   | |.|   |   .... |  .||.   .||  ..         ..||||  | |. .   . 
fgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsd

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
  |.  ... .||. .||.  | |.   |||. ||. .......||.
lliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0041856 (Phosphotyrosine protein) phosphatases II 2-230 5.9e-34 112.6 In-house 3-170 (182) alignment 
Range on Protein: 2-230
Range on HMM: 3-170/182.0
DKNRSTQFLPPNNHRvplkneHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenenneevCYQYWPstpsplvigeynitl
|||| . .||... |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||               
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

sseetcngyierkfevkntnTAATQSVTQYQITNWDSTGKMTnPQTILLVIEEMYRtqrkrGNTSIVVHCSGTVSRSAMFCAAATTINKckteGvIDVFQ
                    .  .. ..||. ..|.  |  . ....|  |||...      .  ..||||. |.|.....||   . .    | .....
....................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vslee

VLKSQRIQKPGSVQTVQQYQGIFQIVLTY
..|  | ..||.|.| .||. . ...| .
avklvrsrRpgmvitpnqyfflqlallel
0049772 (Phosphotyrosine protein) phosphatases II 2-237 1.6e-27 92.5 In-house 48-286 (314) alignment 
Range on Protein: 2-237
Range on HMM: 48-286/314.0
DKNRSTQFLPPNnHRVPLKN---EHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM-----------------
||||....|| . .|| |..   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||                 
dknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAl

----LCHENENNeevcyqywpSTPSPLVIGEYNitlsseetcngyierkfEVKNTNTAATQSVTQYQITNWDStGKMTNPQTILLVIEEMYRTqrkRGNT
    |.   .|.         . |..  . ...                 |. . .   .. . .|  ....  |    .. .. ..| . .    . ..
gKtpllildgng.........neptaadlellk.................eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkgg

SIVVHCSGTVSRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVQQYQGIFQIVLTYLDSFETY
 ..|||.. ..|.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. ....
pvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2-238 6.7e-26 86.0 In-house 43-286 (307) alignment 
Range on Protein: 2-238
Range on HMM: 43-286/307.0
DKNRSTQFLPPNNHRVPLKNE--HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTP-SPLVIGEYN
|||| ..    .. |. .| .    ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.  |  .  | ||||      || || .
dknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap

ITLSSEETCNGYIERKFEVKNT------NTAATQSVTQYQITNWDSTGkmtNPQTILLVIEEMYRTQRKrgNTSIVVHCSGTVSRSAMFCAAATTINKC-
 |.| ..   . .    .. |        .  .......| .||   |    ||. |  |. .  .. .  .  .|||||  | ||    | .   .|  
ntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmi

KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL-DSF-ETYS
. .   |. ....  | |.. ..||  ||  . ...| |. . . ||| 
aGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
subfamily_ptpA1_pd Subfamily ptpA1 2-190 2.7e-21 70.8 In-house 49-255 (418) alignment 
Range on Protein: 2-190
Range on HMM: 49-255/418.0
DKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPS-------
 ||| |. || |  || ||.    |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .|.||    | .|||           
sknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiy

---PLVIGEYNITLSS--EETCNGYIERkfEVKNTNTAATQSVTQYQITNWDSTG--KMTNPQTILLviEEMYRTQ-----RKRGNTSIVVHCSGTVSRS
     |.| |.. |    ..     | |  ... |    |. .||||   |        |.|   ||    .   |         |  |.||||  | |.
gngnevfgtysvelveviqdpereiitr..nirltfegetrditqyqyegwpdhnipdhtqpfrqll..hsitnrqnqiipssdrnvpiivhcsagvgrt

AMFCAAATTINK
  ||.|   ..|
gtfctavimmkk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2-231 1.9e-16 54.4 In-house 53-285 (302) alignment 
Range on Protein: 2-231
Range on HMM: 53-285/302.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCHENENNEeVCYQYWP-STPSPLVIGEY
.||.|...  .....| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  |.| ..    ...|  . . .  |. 
kknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkm

NITLSSEETCNGYI-ERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGtVSRSAMFCAAATTINKCKTEGV
 .     |  ..   .   ||   . . .  .. | .||| ..   ..  ..   .....  . |  .....|   | . | ..| ..|....| ...  
fvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknG.aGRagafltlavaveklqkgke

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
  . ...|| | |.| .|....||  .. ..|.|.
pnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-88 6.9e-15 49.3 In-house 47-145 (392) alignment 
Range on Protein: 2-88
Range on HMM: 47-145/392.0
DKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH----ENENNEEVCYQY----WPST
 |||  . || .. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. .    .. ..   . |.    ||  
kknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2-227 2.9e-09 31.0 In-house 49-275 (303) alignment 
Range on Protein: 2-227
Range on HMM: 49-275/303.0
DKNRSTQFLPPNNHRVPLKNEhpDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYNITL
|||| .. .  .  .| | .    || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| ..      .|     | . |  | .
dknrfvdvicldhskvklsds..syihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirv

S---SEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTIlLVIEEMYRTQRKRGNTSIVVHC--SGtVSRSAMFCAAATTI-NKCKTEG
      |  .|.  .   | | .  .   | .|.    .|    ..|. .   | ..    ||  ...  |.   || . |.  |.   |.     . . 
gefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfv.kqiwqlqsvlrkysdstptvymslsg.cgragtfalfetahlslhseqa

VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
 .|. ..|.  |  .  .|| . |.  .. ..
sldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3-236 5.6e-71 234.2 In-house 51-288 (305) alignment 
Range on Protein: 3-236
Range on HMM: 51-288/305.0
KNRSTQFLPPNNHRVPLKNEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSP-LVIGEYNI
...... |...  ..  |....  ||||| ...|||.||..|.| .|. || ..||..| .  |. ||||..  |.... |.|||| . .    .||...
rlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsv

TLSSEETCNGYIERKFEVKN-TNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVID
.|.||.| ..|||||... .  .   ...|.|||.|.|   |  . . ..| .|... ..|.|  .....|||| .|.|. .|.|    ....|.|.|.|
elksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvd

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
||.|||  | .... ||| .||. .....  .. ...|
vfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_Ptp69D_pd Subfamily Ptp69D 3-236 6.7e-54 178.1 In-house 51-291 (307) alignment 
Range on Protein: 3-236
Range on HMM: 51-291/307.0
KNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTpSPLVIGEYN
|||. .  . ...|| ||    .|. ||||| ||.|||||| ||.|  |. .|. .||.|| . .|| ||||  ..| |.. | .|||        |. .
knRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdil

ITLSSEETCNGYIERKFEVKNTN-----TAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKT
..| |||... ||.|...| ...       ... |.||. |.|. .     ....| .||...  ...  .. ||||||  |.||..| | .  ....|.
vklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlka

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
|  .|.|.. |  | |..  ||  .||. ... .| | .  .|
edkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 3-228 1.9e-34 113.9 In-house 6-236 (237) alignment 
Range on Protein: 3-228
Range on HMM: 6-236/237.0
KNRSTQFLPPNNHRVPLKN--EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYNI
|||  .    .  || ||      ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    |.||. |..|||||  |   | . .
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltv

TLSSEETCNGYIERKFEVKNTNTA-ATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVI
.|  .|    |  | . . .  |    . . |||.| |   |   .  ..|    ..    ..    .  ..|||  | |...|    . . ..| . |.
slkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
|... ..|   ..|  .|| .||  |.| .|
diynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3-234 8.6e-30 98.4 In-house 59-286 (290) alignment 
Range on Protein: 3-234
Range on HMM: 59-286/290.0
KNRSTQFLPPNNHRVPLKNEHP-DYINAVFINGYKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPS-PLVIGEYNIT
|||  .    .  || ||. .. ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||   |.    | ||.| .    | .||. ..
knrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvl

LSSEETCNGYI-ERKFEVKNTNTAATQSVTQYQITNWDSTGkMTNPQtiLLVIeEMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTInKCKTEG-VID
 | |.. .  |  . . |.. ..     .  ..|  |     ... .  | ..  . |. ||  .  .|||||  . |.  | |  ... .. ..|  .|
cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valst..lall.rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeld

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
. .. .. |  . .|||   ||  . .|.| .  .|
lldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3-231 1.9e-23 77.9 In-house 38-270 (285) alignment 
Range on Protein: 3-231
Range on HMM: 38-270/285.0
KNRSTQFLPPNNHRVPLKNEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLV-IGEYNIT
 || ..    .. || |||   ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.|     .| .|.|.||
lnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeit

LS--SEETCNGYIERKFEVKNTNTAATQSV--TQYQITNWDSTgkmTNPQTILLVIeEMYRTQRK--RGNTSIVVHCSGTVSRSAMFCAAATTINKCKTE
|.   ||.  | |   . | ||. |... .   . |.  |        |.    .| |.|.  .|    .. |.||||  | |.| |     .  .   .
lteckeeaiagtilnaltvintedasseplymnhvqvpwwpdq...lapedarpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimen

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
  |.......  |  .  .||.  |.  .. ... |.
pniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3-232 4.4e-22 73.2 In-house 51-288 (305) alignment 
Range on Protein: 3-232
Range on HMM: 51-288/305.0
KNRSTQFLPPNNHRVPLKNEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVI---GEYN
|||  .    .| || |..  | .|| | ..    . | || ...|. .|  .|| |  . .| || |||   |   . |..|..|   . .    ..  
knrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk

ITLSSEETCNGYIER--KFEVKNTN------TAATQSVTQYQITNWDSTGKMTNPQTIllvIEEMYRTQRKRGntSIVVHCSGTVSRSAMFCAAATTINK
|..  | . .  ...  | .|..|        . .. ||.|   .|   |  .  ..|   .| . ...  .|   ||||||  . |.         ...
isvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai...lellekarpskg..pivvhcsagigrtgsvvmleyildq

CKTEGVID-VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
  .  .|.   ..|.  | |.  |.|| .||  . |..| |. 
llagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_CG42327_pd Subfamily CG42327 3-155 1.1e-19 65.3 In-house 31-190 (319) alignment 
Range on Protein: 3-155
Range on HMM: 31-190/319.0
KNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPS---TPSPLVI
|.|  . .|  . || |.    ...  |..| .. ||.. .. .| |. .. ... .||... ...   || |.   |.  .|| .|.|.    ..  . 
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GEYNITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQItNWDSTGKMTNPQTILLVIEEM
|.. .||   |. . |.   . .|. .   .. .| |   .|  ..  ....... .. |.
Gdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 3-230 8.3e-19 62.3 In-house 55-289 (310) alignment 
Range on Protein: 3-230
Range on HMM: 55-289/310.0
KNRSTQFLPPNNHRVPL---KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPL---VIGE
||| .. .  .. || |   |  . ||| | ...    ...|| .. |.  |  .||.|| .    .|..||.  |.    |  ||||        .|  
knrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirv

YNITLSSEE--TCNGYIERK-FEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNtsIVVHCSGTVSRSAMFCAAATTINKCKT
 |.. ||||   ||  .     .|   .  |     . .. .|     .  |.     . .   .| . |    |||||  . |  . .|   .|.| . 
tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldr

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
   .|. .|    . ..   .||  ||  | .. . .
glkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3-148 1.1e-16 55.2 In-house 99-242 (244) alignment 
Range on Protein: 3-148
Range on HMM: 99-242/244.0
KNRSTQFLPPNNHRVPLKNEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEevcyqYWPSTpSPLVIGEYNI-
|||    || .  |||| .      |||| |.        .|... |. .|. .||||. .| |  .|.|   .|..|     ||| .  ||   | .| 
knregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpds.eplewyeedit

-TLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTI
 ||.  .        ..|..     . |..| .||.|| | |   |   |
vtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndhfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3-89 7e-16 52.9 In-house 36-126 (297) alignment 
Range on Protein: 3-89
Range on HMM: 36-126/297.0
KNRSTQFLPPNNHRVPLKNEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTP
||| .. |  .. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|.  . |. ||||. 
knryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3-88 1.9e-12 41.6 In-house 50-153 (350) alignment 
Range on Protein: 3-88
Range on HMM: 50-153/350.0
KNRSTQFLPPNNHRVPLK------------NEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQY
||| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  . |.| | ||.|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPST
|.  
Wqeg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-232 1e-40 134.5 In-house 24-265 (270) alignment 
Range on Protein: 4-232
Range on HMM: 24-265/270.0
NRSTQFLPPNNHRVPLKNEHP----DYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSP---LVIG
||... ||  . || |....      |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|.. . | .|||. |     |  |
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledg

EYNITLSSEETCNGYIERKFEVKntNTAATQSVTQYQITNWDSTGK------MTNPQTILLVIEEMYRTQRKRGN-TSIVVHCSGTVSRSAMFCAAATTI
. ... .|||  .||| .. ...  ... .. .. .. ..|   |        .... .| ..... |....  . . ..||||  | |. .. |  ...
kikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiav

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.  .... .|| ....  | ...  ||...||. ... |..| .
rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5-231 4e-21 70.3 In-house 48-271 (288) alignment 
Range on Protein: 5-231
Range on HMM: 48-271/288.0
RSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLV-IGEYnITLSS
| ..    .  || |...   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |   |   .|.||     . || .  |   
ryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.ctvvk

EETcnGYIERKFE---VKNTNTAATQS-VTQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDV
..     |..  .   ......  ..  | .  . .||  |   | .. | ..| .     |  .  ||||.|  | |.. .      ..  . .  . .
kkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgi

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 ..|.. | ..  ..|| .||  ....|| .|
rsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 9-74 1.1e-08 29.0 In-house 55-120 (347) alignment 
Range on Protein: 9-74
Range on HMM: 55-120/347.0
FLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEN
 | |.. .    ..   ||||  |.  . .| .|... |. .| |.||||.   .|| .| .    
vlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 13-237 9.6e-15 49.1 In-house 56-282 (312) alignment 
Range on Protein: 13-237
Range on HMM: 56-282/312.0
NNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYNI------TLSSEET
.  |  |  .   || | |..     . |.....|. ||. .||..      |.|..||   |.  | | .|     . . . .. .       .     
drgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggk

C-NGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSGTVSRSAMFCAAA---TTINKCKTEGVIDVFQV
  .    | . |    |     . .|| . |   |     .| | ..  .     |. .  .. |||  | |.  ..      ... . . . | |.| .
skdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl

LKSQRIQkpgSVQTVQQYQGIFQIVLTYLDSFETY
|. .| .   ||... ||   ...|| .| |   |
lrkdrar...svrvfpqyvyalrcvleflyskgly
0046846 (Phosphotyrosine protein) phosphatases II 16-232 4.9e-30 100.0 In-house 4-174 (176) alignment 
Range on Protein: 16-232
Range on HMM: 4-174/176.0
RVPLKNEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVigeynitlsseetcngyierkf
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. | | .   |..|||   .. .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

evkntntaatqsvtQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKrGnTSIVVHCSGTVSRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              ||. ..|.  |  .  . .| ..|.... ... |   ..||||. ..|.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTVQQYQGIFQIVLTYLD
|| .||. . . .| .|.
qtpeQyrflyefellllk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 17-230 1e-24 81.7 In-house 60-268 (281) alignment 
Range on Protein: 17-230
Range on HMM: 60-268/281.0
VPLKNeHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPS-PLVIGEYNITLSSEETCNGYIERKf
.| ||   ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | | | | .|.|      | . .. ..       .  .  . 
mpnkn.stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.

eVKNTNTAATQSVTQYQITNWDSTgKMTNPQTILLvieEMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGS
 .. .    |. .|..   .|    .. .   ..|   .. |  | |  |  |.|||  | ||  . |   ...  ..   . |. |..   |.  .  |
.lnlsyegetrlithwlwkewpdw.qvpessevml...kilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraas

VQTVQQYQGIFQIVLTY
|||.|||  |....| .
vqtlqqymliwkvlldf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 18-233 6.6e-50 164.8 In-house 59-278 (281) alignment 
Range on Protein: 18-233
Range on HMM: 59-278/281.0
PL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYNITLSSEETCNGYIER
 .    .|.. ||||| |..|||..|..|....|. ..  .||.|. ...|.||||. .| |..   |..|||   | | .|.. ..  .||. . ||||
kvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyier

KFEVkNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPG
||.. ..... |..|.| . |.|  .|  .... .|   .|......|. ....|.|||  | |.  . |  . ......|   .|| .|... | ..  
kfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernl

SVQTVQQYQGIFQIVLTYLDS
 |||| ||. ....|| .|| 
mvqtvvqyefvykavldaldk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 19-239 2.3e-63 208.7 In-house 65-301 (301) alignment 
Range on Protein: 19-239
Range on HMM: 65-301/301.0
LKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTP-SPLVIGEYNITLSSEE------------
|.  . .|||| .|.||.|||.||.|..|| .| ..||..| .  ...|||.. ..|. .. |.||||..  .    |. ..||..|             
ldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnv

-----TCNGYIERKFEVKNTNtaATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVF
     . ||||||||.||...  ....|.|.|.|.|   | . .|.|.| ||...  .|.| |   .||||| ||||| ..|.   ..  || |||.|||
kiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf

QVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
|| |. | .||| |.| .||  |.... .||   .||.|
qvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
0044763 (Phosphotyrosine protein) phosphatases II 19-227 4.3e-23 77.3 In-house 13-167 (178) alignment 
Range on Protein: 19-227
Range on HMM: 13-167/178.0
LKNEHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSplvigeynitlsseetcngyierkfevk
   |  |||||..| ..     ....  |.     ...... . ..|.||.|..| |.. . |..|||.  .                            
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

ntntaatqsvTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSGTVSRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVQ
           ||. ....  |  . .. .| ..| . . .  . .  ..||||  |.||....||   .      |. .......  | ..|  |..  
..........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpg

QYQGIFQIV
|.. . .. 
qlrqLyefe
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 20-231 8.4e-20 65.6 In-house 75-289 (305) alignment 
Range on Protein: 20-231
Range on HMM: 75-289/305.0
KNE-HPDYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYNITLSSeETCNGYIERKFEV
..    ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  |     | |||| .    .     | .    . .  .||  |.
dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivven.vsgskpmerdaei

KNTNTAA------TQSVTQYQITNWDSTGKmtnPQTILLVIEEMyRTQRkRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQK
. |          . || . | |.|   |    |   |  .| .  . |   .  ||||||  . |.    |    ..|   .  .  . ...|. | |.
qitllnltysgdqkmsvrhlqwtewpdrgv...ppckltslell.sair.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqr

PGSVQTVQQYQGIFQIVLTYL
  |.|.  ||  | ...| |.
afsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 20-75 3.8e-07 23.9 In-house 56-112 (332) alignment 
Range on Protein: 20-75
Range on HMM: 56-112/332.0
KNEHPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENE
.. . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |...   .|
qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 21-228 4.4e-29 96.3 In-house 32-237 (239) alignment 
Range on Protein: 21-228
Range on HMM: 32-237/239.0
NEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVigEYNITLSSEETCNGYIERKFEVKN
. | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |  .  .  .||   |    || | | . .
dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..nlrvtlrktevfadyiirtfvmsq

TNTAATQSVTQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
   .  . | ||..| |   |      | .| .      .   |    |.|||  | |.  |    . . ..| .  .|.|. .|. | ..|  ||| .|
vgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseq

YQGIFQIVL
|  |.  ||
yvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 21-228 4.9e-29 96.2 In-house 33-238 (239) alignment 
Range on Protein: 21-228
Range on HMM: 33-238/239.0
NEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVigEYNITLSSEETCNGYIERKFEVKN
. | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |  .  .  .||   |    || | | . .
dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..nlrvtlrktevfadyiirtfvmsq

TNTAATQSVTQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
   .  . | ||..| |   |      | .| .      .   |    |.|||  | |.  |    . . ..| .  .|.|. .|. | ..|  ||| .|
vgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseq

YQGIFQIVL
|  |.  ||
yvfihlavl
0043147 (Phosphotyrosine protein) phosphatases II 22-224 1e-29 98.9 In-house 3-154 (172) alignment 
Range on Protein: 22-224
Range on HMM: 3-154/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnenneevcyqywpstpsplvigeynitlsseetcngyierkfevKNTN
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TAATQSVTQYQITNWDSTGKMtNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVQQY
.  .... ||. ..|.  |   ... .| ..| ... . .. .  ..||||. |.|.....||   .        . .......  | ..||.||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

QGIF
. . 
rfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 22-229 3.5e-26 86.7 In-house 74-277 (439) alignment 
Range on Protein: 22-229
Range on HMM: 74-277/439.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENEnneevCYQYWPSTPSpLVIGEYNITLSSEETCNGYIERKFEVKNTN
 |  |||| .|.|| ..| .| .. |  .|. .||... ..... ||||.   |      |.||||     . |.  .    .     |. | | | |  
phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsdae.vcygdiavrvdrnielpnyvirgfkvfner

--TAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
  |   ..| |.. . |      ..   .|  .  .  .. |.    .|||||  | |.    |   .... |.|  .|.  ..|  | |.   ||.. |
dttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

YQGIFQIVLT
|  |.. || 
yvfiynavle
subfamily_eak_pd Subfamily eak 22-140 1.7e-09 31.5 In-house 76-193 (332) alignment 
Range on Protein: 22-140
Range on HMM: 76-193/332.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTP-SPLVIGEYNITLSSEETCNGYIERKFEVKNT
..  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. |.. |   .|.|      |  | ....  .    | .  |..|..  
nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskG

NTaaTQSVTQYQITNWDSTG
|   |  |  |..  |  | 
ne..thrvlhykvfGwtett
0051429 (Phosphotyrosine protein) phosphatases II 23-234 5.2e-37 123.3 In-house 3-228 (272) alignment 
Range on Protein: 23-234
Range on HMM: 3-228/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENENNEEVCYQYWP-----------STPSPLVIGEYNITLSSEETCN
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.| . . |..|||           ... .  .| . .|| |||...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKFEVKNT-NTAATQSVTQYQITNWDSTGKMTNPqtILLVIEEMYRtqrkrgNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVID--------V
 || |....... .. ..  |.... |.|   |  ...  .| ..|.. .      .  ..||||. ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
.....  | | ||.||| .||. .....| .|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
0051082 (Phosphotyrosine protein) phosphatases II 23-225 1.1e-23 78.9 In-house 2-147 (151) alignment 
Range on Protein: 23-225
Range on HMM: 2-147/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENENNeeVCYQYWPSTPsplvigeynitlsseetcngyierkfevkntnt
..||||. .. |.     ...   |       |.... . ....||.|. | |..   |..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

aatQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRtqrkRGNTSIVVHCSGTVSRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQG
     |....|..|. .|  ......| ..|.. .     .|  ..||||. ..|.....|.   . .      ......|.  |.. ||.||. ||.. 
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IFQ
...
qlf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 23-144 6.5e-15 49.6 In-house 12-129 (130) alignment 
Range on Protein: 23-144
Range on HMM: 12-129/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEevcyqYWPSTpSPLVIGEYNITLSSEE-TCNGYIER-KFEVKNT
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|..|     ||| .  ||   | .|.... .     .|.  ..|... 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpds.ePlewyeediivtltdrdefknikasnleiesd

NTAATQSVTQYQITNWDSTGKMTN
   . |..| .||.|| | |   |
lneshqaltmfqisnwpsdgttpn
subfamily_egg_pd Subfamily egg 24-231 8.9e-21 68.8 In-house 68-270 (307) alignment 
Range on Protein: 24-231
Range on HMM: 68-270/307.0
PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENneEVCYQYWPSTPS-PLVI--GEYNITLSSEETCNGYIERKFEVKNT
 |.| |  ..|      ||.|..|. ||  .||.|.   .|  ||||    |.  | |  ||| ..| .||.  | ..|.    .     . |  ..|  
ddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklv

NTAAT-QSVTQYQiTNWDSTGKMTNPQTILlvieemyRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQT
 .    . .  .|  ... ....  |  .|       |  |.   . .||..   ||..| . |. ... .    | |  . ||..    | ... ||..
Ggddeerflehwq.gdvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsves

VQQYQGIFQIVLTYL
| .|  ....|| ..
vllylfvyrlvlfff
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 24-229 5.9e-20 66.6 In-house 46-257 (290) alignment 
Range on Protein: 24-229
Range on HMM: 46-257/290.0
PDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENENNEE----VCYQYWPSTPS-PLVIGEYNITLSSEETCNGYI
 ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .|....     | .| | .    | ..  ..   | |. .. .
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

ERKFEVKNTNTaATQSVTQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSGTVSRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQK
.|. .||  .      || ... .|...    ...|.| .|. .     |  .| ..|||   .||||.. |      |   |.| . . .|||. | |.
tRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PGSVQTVQQYQGIFQIVLT
   ... ...  .   .. 
alaitsalelafvdagivl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 24-120 2.5e-08 27.6 In-house 90-188 (349) alignment 
Range on Protein: 24-120
Range on HMM: 90-188/349.0
PDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTP-SPLVIGEYNITLSSeETCNGYIERKFEVKNT
 ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..||     |   .   |  | .    .|   | ..||.|
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyi.anvqGnslrvstvkdt
0036282 (Phosphotyrosine protein) phosphatases II 25-225 3.3e-35 116.7 In-house 3-164 (174) alignment 
Range on Protein: 25-225
Range on HMM: 3-164/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPStpsplvigeynitlsseetcngyierkfevknTNTAA
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.|.. . |..|||.                                . .  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

TQSVTQYQITNWDSTGKMTNPQtILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
.... ||. ..|.  |  . .. .| ....... . . ..  ..||||. |.|.....||   .   . |...|........| |.||.||| .||. . 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 27-220 1.2e-29 98.0 In-house 78-270 (301) alignment 
Range on Protein: 27-220
Range on HMM: 78-270/301.0
INAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGEYNITLSSEETC--NGYIERKFEVKNT-NT
| | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... |..||.| .| |.. .. | || ..|.. ..|.   .  ..|..||... . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

AATQSVTQYQITNWDSTGkmtNPQTILLVIEEMYRTqrKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
 ||..|| || ..|   |    |..   . . |     |. .  ||||||  . ||  | ..    .. ...  |.. . ||  | ..  .|||..| 
fatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
0049260 (Phosphotyrosine protein) phosphatases II 31-224 4.5e-29 96.5 In-house 1-143 (152) alignment 
Range on Protein: 31-224
Range on HMM: 1-143/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWpstpsplvigeynitlsseetcngyierkfevkntntaatqsvtQ
||.||. ...||... |. ||. .||.|. . ..|.||||. . |.... |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSGTVSRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
|. ..|.  |  ...| .| ... . .  ... .  ..||||. |.|.....||   .        ........  | ..||.|.. .|.. ..
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 31-119 1.3e-11 38.5 In-house 228-313 (440) alignment 
Range on Protein: 31-119
Range on HMM: 228-313/440.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcheNENNEEVCYQYWPSTPSPLVIGEYNITLSSEETCNGYIERKFEVKN
 ..||  |.||| .. |.  |  .||... | ....|.||   |. |.  |  |||     . .| . .     |  |    | .|.| 
efegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 36-226 1.5e-17 58.4 In-house 2-199 (199) alignment 
Range on Protein: 36-226
Range on HMM: 2-199/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPL-VIGEYNITLSSEETCNGYIERKFEVKNTNTA--ATQSVTQYQ
| .. .| .. |. .|  .||.|. .     |||.  .. |.|     |||.| |     |  ..|  .  |   |    . . |  ||  .|. ...||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWDSTgkmTNPQTIL-----LVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
.| |      | |.  |     .   |. .   .  .. ..||||     . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.
ftswkek...ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiy

QI
|.
qv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 37-226 2e-17 58.0 In-house 2-198 (198) alignment 
Range on Protein: 37-226
Range on HMM: 2-198/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPL-VIGEYNITLSSEETCNGYIERKFEVKNTNTA--ATQSVTQYQI
 .. .| .. |. .|  .||.|. .     |||.  .. |.|     |||.| |     |  ..|  .  |   |    . . |  ||  .|. ...||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWDSTgkmTNPQTIL-----LVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
| |      | |.  |     .   |. .   .  .. ..||||     . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|
tswkek...ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq

I
.
v
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 43-231 7.9e-16 52.9 In-house 39-221 (255) alignment 
Range on Protein: 43-231
Range on HMM: 39-221/255.0
IaespmfnTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSP-LVIGeyNITLSSEETCNGYIERKFEVKNTNT--AATQSVTQYQITNWDST
.       |  .|...|   . . .||||  .|.. | | .|.|      |..   ...... .. .  . |  |.  | .    |. |. |. . |   
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla..dvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiek

GKMTNPQTILLVieemYRTQRKRgnTSIVVHCSGTVSRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
    ... || .    ..  |.    |.|||||  . ||| |  |            . .| . .|  ..|.  | .......|  |    . .||...
naPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 43-230 4.1e-15 50.4 In-house 42-226 (263) alignment 
Range on Protein: 43-230
Range on HMM: 42-226/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSP-LVIGeyNITLSSEETCNGYIERKFEVKN--TNTAATQSVTQYQITNWDST
.    . .|  .|...|   . . .||||  ||.. | | .|.|      ...   |..... .. .  . .  |. .   .   |. |..|. . |  .
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla..nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

GKMTNPQTILLVIeemyRTQRKRgnTSIVVHCSGTVSRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
   .... || ..    .  |.    |.|||||  . ||| |  | .          . .| . .|  ..|.  | .......|  |    . .||..
ndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 44-224 1.5e-15 51.5 In-house 96-281 (302) alignment 
Range on Protein: 44-224
Range on HMM: 96-281/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPST-PSPLVIGEYNI-TLSSEETCNGYIERK------FEVKNTNT--AATQSVTQYQI
   |  .|   .| .|.. ||. .| ||.  |..|. | .|.       |  |.| . |.| ..  . . ..|       |.||...  .  ..|   . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGKMTNPQTILLVIEemYRTQRKrgnTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. |   |   ...| | ..   .    |   ....||||  | |.  . |    |. |... | |. ....  |  . |.||. ||   ..
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 53-231 4.5e-08 26.1 In-house 132-309 (346) alignment 
Range on Protein: 53-231
Range on HMM: 132-309/346.0
RNFWKMIDDRNVTAIVMLCHENENNEEVCYQYWPSTPSPLVIGEYNITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVI
 .|| || . ..  . ..  ..  ..     .          |   |     .      |   ||     . .  .  .. . |    .  .   |. .|
edfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmi

EEMYRTQRKRGNTSIVVHCSGtVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 ...  .. .     ||   |   |.  |  |  .||.       ......|. . |.||.|..  || .|. ||. |.
hqflsekqvqnagvcvvslfg.cgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
0048179 (Phosphotyrosine protein) phosphatases II 57-224 3.6e-15 51.4 In-house 23-138 (144) alignment 
Range on Protein: 57-224
Range on HMM: 23-138/144.0
KMIDDRNVTAIVMLCHENENNEEVCYqywpstpsplvigeynitlsseetcngyierkfevkntntaatqsVTQYQITNWDSTGKMTNPQTILLVIEEMY
... . ..|... |..| |.... ..                                             ..||. ..|.  |  . .. .| ..| . 
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

RTQRkrGNTSIVVHCSGTVSRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. ..   .  ..||||. |.|.....||   .    ..| ......|.  | . ||.|.. .|.. . 
eale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 84-229 5e-16 54.1 In-house 2-141 (145) alignment 
Range on Protein: 84-229
Range on HMM: 2-141/145.0
YWPSTPSP-LVIGEYNITLSSEETCNGYIERKFEVKNTNTAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrgNTSIVVHCSGTVSRSAMFC
||||   | | .| .  .|. |. ..  | . . . .. .  .. ..||. ..|.  |  . ....| ..| . . ...  .  ..||||  |.|.....
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv

AAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
||   .     .| ......|.  | | ||.|....|.. ... .| 
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefele
PTPc_motif_SM00404 108-204 3.8e-06 21.8 In-house 41-121 (140) alignment 
Range on Protein: 108-204
Range on HMM: 41-121/140.0
NgyierkfevkntntAATQSVTQYQITnWDSTGKMTNPQTILLVIEEMYRTqrKRGNTSIVVHCSGTVSRSAMFCAAAT-TINKCKTEGVIDVFQVLK
.               ......  ||   | ..|    . .  |.. . .   .. .....|||   |||||....|   . ...... ....... .
t..............kensgfqilqip.lddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 111-233 2e-15 51.1 In-house 263-387 (392) alignment 
Range on Protein: 111-233
Range on HMM: 263-387/392.0
IERKFEVKNTNTAATQSVTQYQITNWDSTGKMT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRI
.  |   .  .. |. .|||||.  |   |       ...| .|  .  .  .. . ||.|||     |. .||.|   | .      .|.|| .|  | 
vrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilra

QKPGSVQTVQQYQGIFQIVLTYLDS
..  .||| ..|  .....  || .
drmqfvqteeeyafvydvireylht
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 122-231 4.8e-14 46.5 In-house 85-194 (440) alignment 
Range on Protein: 122-231
Range on HMM: 85-194/440.0
TAATQSVTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
   .... ||.   |   |       .| .|...  .| | ||  ..||||  ..|...  |  . . ..|    ||.| ...| | ..|  ||| .|| 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

GIFQIVLTYL
 ... ||  |
fvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 126-189 9.3e-06 19.6 In-house 215-287 (350) alignment 
Range on Protein: 126-189
Range on HMM: 215-287/350.0
QSVTQYQITNWDSTGKMTNPQTILLVIE--------EMYR--TQRKRGnTSIVVHCSGTVSRSAMFCAAATTIN
  | | |. ||   . . ||. || ..|         . .   . .|. ..|.||||  | |  ....    ..
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDslls
PTPc_DSPc_SM00012 128-227 3.4e-22 74.0 In-house 2-103 (105) alignment 
Range on Protein: 128-227
Range on HMM: 2-103/105.0
VTQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG-NTSIVVHCSGTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
|..|..|.|  .|. .... || ..... . ..|.. ....|||||  |.|...|.|... ......| . .|.||..|. | |.||.||| .||. . .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IV
..
al
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 154-230 2.7e-10 34.6 In-house 219-294 (297) alignment 
Range on Protein: 154-230
Range on HMM: 219-294/297.0
EMYRTQRKRgNTSIVVHCSGTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
| .|..  | |. ..||||  | || .   . . ..| . . . ||  .|.  | |..  |||..|.. ....||  
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_CG42327_pd Subfamily CG42327 159-230 1.7e-07 25.2 In-house 242-314 (319) alignment 
Range on Protein: 159-230
Range on HMM: 242-314/319.0
QRKRGNTSIVVHCSGTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 ..  .  .|||||  | |. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey