Gene PTPRD-32 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP087_AA protein Get Run
AqueP087_AA_789-1009 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 294-374 2.9e-12 39.8 Pfam-A 5-83 (85) alignment 
Range on Protein: 294-374
Range on HMM: 5-83/85.0
DIILSSVESVSMTVSWDEVPcnGRKGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLRGLIPYTNYTVSIIPYNYNMNGP
.. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|.|| |.|.|....  .| . .||
nlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 397-468 8.3e-14 44.7 Pfam-A 11-84 (85) alignment 
Range on Protein: 397-468
Range on HMM: 11-84/85.0
KNPDAINIVWNPPTIPNGIITVYEIRYRESTSTG-SYTITNTTDT-IYSIVGLIPNTSYTIGVRAYTSIGPGEW
 ... ... |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
Ig_3 Immunoglobulin domain 677-751 6e-07 21.6 Pfam-A 1-75 (75) alignment 
Range on Protein: 677-751
Range on HMM: 1-75/75.0
KPVIEEFPSNMTTEEGCqVLLKVKVKDTS-KPSFNWYHNGDLVTDDYAHELRGDGSLLLVSVEEKHKGTYRFVANN
||||   ||...|..|  | |   ..... .|.. ||  .. . .       ....| . || ... |||. ||.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 677-764 9.9e-07 20.7 Pfam-A 1-80 (80) alignment 
Range on Protein: 677-764
Range on HMM: 1-80/80.0
KPVIEEFPSNmtTEEGCQVLLKVKVKDTSKPSFNWYHNGDLVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANND-AGTVSQQVVLTV
|||... |..   .||..| |  ....  .|.. ||..|....   .        |.. .|.....|||. .| |.  ...|. | .||
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
I-set Immunoglobulin I-set domain 678-764 1.9e-13 42.0 Pfam-A 1-90 (90) alignment 
Range on Protein: 678-764
Range on HMM: 1-90/90.0
PVIEEFPSNMTTEEGCQVLLKVKVKDTSKPSFNWYHNGDLVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVSQQVVLTV
|.... .......|| .| |...|. . .||..|...|  .. .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
0051299 (Phosphotyrosine protein) phosphatases II 785-1008 8e-51 168.6 In-house 3-272 (288) alignment 
Range on Protein: 785-1008
Range on HMM: 3-272/288.0
NLIPVRQFGEFVANGHAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVS-----------------------------------------
. |.|... ..| . .|.|. |....| .| |   |.| .|.| | |.  ||. .|.                                           
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

---RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILGEYNITLLKENTSNRYIERKFEVKNT----NTGAKQSVTQFQVTNWDSTGEVKNP
    .||.|. . ||. ||||... |.. | |.||||. .. ...|.. .|||.| . . |. |..||.|.     .| .. ||.|..|||   |   .|
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

QTILMIIEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .| ......| ..  |.  .|||||. |||.. |.|. . ..  ..||..||....|  | |.||.|||.
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0045450 (Phosphotyrosine protein) phosphatases II 786-1008 1.5e-46 154.9 In-house 8-290 (307) alignment 
Range on Protein: 786-1008
Range on HMM: 8-290/307.0
LIPVRQFGEFVANGHAKGNEGFKNQFMMLDSGES--DHTGTAGLTPSNKLLNRFANIVVS----------------------------------------
.|.....  .|.  ......|.. .| .| | .    .. ...| | || .||. .|.                                          
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

-------------RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNT-NTGAKQSVTQFQVTNWDS
              .||.|. . .||.||||....|.. | |.||||.... .  |.. .|||.|.. . |. |..||...  ||    ||.|. |.|  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

TGEVKNPQTILMIIEEMYKTQRKR-GNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
.|  ......| .|||. | ...  ... ..||||. |||.. |.|| . .   ..||.   .|.....|  | |.||.||. 
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 786-843 2.9e-22 73.9 In-house 1-58 (290) alignment 
Range on Protein: 786-843
Range on HMM: 1-58/290.0
LIPVRQFGEFVANGHAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVS
|||| .||||||||||||||||.|||.|||||||.|| | |||.|||||||||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 786-844 2e-18 61.4 In-house 1-60 (287) alignment 
Range on Protein: 786-844
Range on HMM: 1-60/287.0
LIPVRQFGEFVANGHAKGNEGFKNQFMMLDS-GESDHTGTAGLTPSNKLLNRFANIVVSR
||||..||||||.|||||||||||||..|.. .....  | .....|| .||...|.|  
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpd
0043336 (Phosphotyrosine protein) phosphatases II 787-1008 3.3e-44 146.8 In-house 2-263 (278) alignment 
Range on Protein: 787-1008
Range on HMM: 2-263/278.0
IPVRQFGEFVANGHAKGNEGFKNQFMMLDSGESdHTGTAGLTPSNKLLNRFANIVV--------------------------------------------
|.| .. ..... ..... .....|  |.|     | . .| | || .||. .|.                                             
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPstSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMI
  .||.|. . .|| ||||....|.. . |.||||  .. .  |.. .|||||.. . |. |..||.|. .| .. ||... ..|   |   .....| .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.... . ..   |. ..||||. |||.. |.|. . ..  ..|| .|.....|  | |.||.||| 
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
0039614 (Phosphotyrosine protein) phosphatases II 791-1008 1.2e-44 148.4 In-house 18-275 (297) alignment 
Range on Protein: 791-1008
Range on HMM: 18-275/297.0
QFGEFVANGHAKGNEGFKNQFMMLDSGESDhtGTAGLTPSNKLLNRFANIVVS----------------------------------------------R
 .  ..   .|... .....|..| |   |   . .| | || .||. .|.                                                 
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

NFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSSgiILGEYNITLLKENTSNRYIERKFEVKNtnTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. . .||.||||....|..   |.||||....    |.. .||||. . . |. |..||.|  .|    ||.||.|.|   |   .....| ..|
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

EMYKTQRKR-GNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. . ...  ... ..||||. |||.. |.|| . .. ...|| .||....|  | |.||.||| 
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0040438 (Phosphotyrosine protein) phosphatases II 792-1008 9.4e-47 155.2 In-house 5-262 (317) alignment 
Range on Protein: 792-1008
Range on HMM: 5-262/317.0
FGEFVANGHAKGNEGFKNQFMMLDSGESDhTGTAGLTPSNKLLNRFANIVVSR--------------------------------------------NFW
. ...   ..... .....|..|.|   | | . .. | || .||. .|.                                               .||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

KMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMY
.|. . .|| ||||....|.. | |.||||.  . .  |.. .|||.| . . .. |..||...... .  ||.|. |.|.  |  ..|...| ..|.. 
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

KTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .. .... ..||||. |||.. |.|| . .. ...|| .||....|  | |.||.||| 
eale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp
0050432 (Phosphotyrosine protein) phosphatases II 794-1008 3.9e-50 166.3 In-house 33-285 (308) alignment 
Range on Protein: 794-1008
Range on HMM: 33-285/308.0
EFVANghAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVS-----------------------------------------RNFWKMIDD
... .  |... ... .|. | |   ... ...| | || .||. .|.                                            .||.|. .
kllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

RNVTAIVMLCQEKENDLEVCYQYWPST--SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQ
 ||. ||||... ||. | |.||||..  .. .. | . .|||.| . . |. |..|..|...|    ||.|. |||   |   .|. .| ..|.. |..
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl

rkrGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.
...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 800-1008 6.2e-48 159.0 In-house 7-258 (273) alignment 
Range on Protein: 800-1008
Range on HMM: 7-258/273.0
HAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVSR----------------------------------------NFWKMIDDRNVTAIV
...|. ... .| .| |   ..| ...| | || .||. .|.                                           .||.|. . ||. ||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLCQEKENDLEVCYQYWPSTSS--GIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKR-GNT
||... |.. | |.||||..     .. |.. .|||.|.| . |. |..|..|..|| .  ||.|..|.|   |   ... .| .||.. |....  .|.
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

SIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .|||||. |||.. |.|. . ..  ..|| .||....|  | |.||.|||.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 801-1008 8.2e-48 158.6 In-house 9-263 (297) alignment 
Range on Protein: 801-1008
Range on HMM: 9-263/297.0
AKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVSRN----------------------------------------FWKMIDDRNVTAIVM
.... ... .|. |..   . . ...| | |. .||. .|.   .                                        ||.|. . ||| |||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LCQEKENDLEVCYQYWPST-SSGIILGEYNITLLKENT--SNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKR-GNT
|... |.. | |.||||..  . .  |.. .|||....  .. |. |..||..|..| .  ||.|..|.|.  |   .|...| .||.. | ...  ...
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

SIVVHCSDTVGRSAIFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
 ..||||. ||||. |.|| . ..  .   .|| .|.....|. | |.||.|||.
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0046845 (Phosphotyrosine protein) phosphatases II 807-1008 6.2e-47 155.7 In-house 2-260 (284) alignment 
Range on Protein: 807-1008
Range on HMM: 2-260/284.0
FKNQFMMLDSGESDH--TGTAGLTPSNKLLNRFANIVVS--------------------------------------------------RNFWKMIDDRN
.. .|..| |   ..  . ...| | |. .||. .|..                                                    .||.|. . |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTN-TGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRK-
|. ||||... ||. | |.||||.... ...|.. .|||.|.. . |. |..|..|.. ||    ||.|..|.|   |   .|. .| ..... . ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTV
 |.  ||||||. |||.. |.|. . ..  ..||   ..||....|  | |.||.|||.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0045098 (Phosphotyrosine protein) phosphatases II 819-1008 2.4e-41 137.3 In-house 21-258 (278) alignment 
Range on Protein: 819-1008
Range on HMM: 21-258/278.0
SDHTGTAGLTPSNKLLNRFANIVV--------------------------------SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILG
.  . | .| ..|. .||. .|.                                   .||.|. . ..|.||||....|.. | |.||||. .. .. |
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltyg

EYNITLLKENTSNRYIERKFEVKNT----NTGAKQSVTQFQVTNWDSTGEVKNP--QTILMIIEEMYKTQR------------KRGNTSIVVHCSDTVGR
.. .|||.| . . |. |...| |.    ... .  ||... ..|.  |   .|  . .| ..|.. . ..              ... ..||||  |||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SAIFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTV
.. ..|| . .  .  ||..|.....|  | |.|| .||. 
tGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 824-979 4.8e-15 50.3 In-house 22-172 (255) alignment 
Range on Protein: 824-979
Range on HMM: 22-172/255.0
TAGLTPSNKLLNRFANIVVSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLKenTSNRYIERKFEVKNTNT--GAKQSVT
| .. |...  ..  ...   .|...|   . . .||||  .|.. | | .|.|    .  .| . |.|  |  .|.  . |  |.  | .     . |.
tehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFQVTNWDSTGEVKNPQTILMIIeemyKTQRKRgnTSIVVHCSDTVGRSAIFCAAATTI
 .. . |      .... || |.    |  |.    |.|||||  .|||| |  |    
hysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvy
0040439 (Phosphotyrosine protein) phosphatases II 825-1008 1.7e-40 134.6 In-house 5-232 (249) alignment 
Range on Protein: 825-1008
Range on HMM: 5-232/249.0
AGLTPSNKLLNRFANIVVS--------------------------------------------RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStS
 .| | || .||. .|.                                               .||.|. . ..|.||||....|.. | |.||||. .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

SGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKR-GNTSIVVHCSDTVGRSAIFCAAATTI
. .  |.. .|||...... |. |..|..|. .| .  |...|.|.|  .|  ......| .||.. | ...   .. ..||||. |||...|.|| . .
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

NKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  ..|. .|.....|  | |.||.||. 
eqlekelgvdleeavkllrsqRpgavqnp
0049772 (Phosphotyrosine protein) phosphatases II 826-999 1.3e-13 46.8 In-house 41-255 (314) alignment 
Range on Protein: 826-999
Range on HMM: 41-255/314.0
GLTPSNKLLNRFANIV-------------------------------------------------VSRNFWKMI--DDRNVTAIVM--------------
.  . |.  ||. .|.                                                 .  |.|.|.  .|.||  |||              
adlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCQEKENDlevcyqywpstssGIIlGEYNITLLKentsnryierkfEVKNTNTGAKQSVTQFQVTNWDStGEVKNPQTILMIIEEMYKTqrkR
       |..  .|              ..   . .. |||            |. . .   .. . ..  ....  |..  .. .. ..| . .    .
aAlgKtpllildgng.............nep.taadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea...d

GNTSIVVHCSDTVGRSAIFCAAATTINKCKTeGVIDVFQVLKSQRI
 .. ..|||.. .||.. |..||  . ...   . .... ....| 
kggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp
0037934 (Phosphotyrosine protein) phosphatases II 827-1008 2.2e-37 124.3 In-house 6-228 (243) alignment 
Range on Protein: 827-1008
Range on HMM: 6-228/243.0
LTPSNKLLNRFANIV---------------------------------------VSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPstSSGiILGE
| | |.  ||. .|.                                       .  .||.|. . ..|.||||....|.. | |.||||  ..    |.
llpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.tygd

YNITLLKENTSNRYIERKFEVKNTN-TGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRK-------RGNTSIVVHCSDTVGRSAIFCAAATTI
. .|||.|.. . |. |.....|.. .. .. |.... ..|   |   .|. .| ...|... ...        ..  ..||||  |||.. ..|| . .
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

NKCkteGvIDVFQVLKSQRIQKPG-SVQTV
 ..   | .|.....|  | |.|| .||| 
lll...g.vdleeavkllreqRpgkavqtp
0042113 (Phosphotyrosine protein) phosphatases II 829-1008 7.1e-41 135.6 In-house 7-229 (245) alignment 
Range on Protein: 829-1008
Range on HMM: 7-229/245.0
PSNKLLNRFANIVVS--------------------------------------------RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGII
| || .||. .|.                                               .||.|. . ..|.||||..| |.. . |.||||. .. . 
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslt

LGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKT
 |.. .|||.|.. . |. |..||.|. .. .. |.... ..|.  |.  .....| ..|.. | ... .|. ..||||. |||.. |.|| . ..  ..
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

EGVIDVFQVLKSQRIQKPGSVQTV
|. .......|  | |.||.||| 
elgvsleeavkelrsqRpgavqtp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 838-1007 9.1e-17 55.5 In-house 96-221 (392) alignment 
Range on Protein: 838-1007
Range on HMM: 96-221/392.0
ANIVVSRNFWKMIDDRNVTAIVMLCQEKENDlevcyqywpstssgiilgeynitllkentsnryierkfevkntNTGAKQSVTQFQVTNWDSTGEVKNPQ
 |.    .||.|. . |||.|.|. . || |                                           .   ...|.||..|.|   .  |   
pnaaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhts

TILMIIEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
..| .|.|. |..  .    ...|||  |||...  .  . . ..|.  ..|||...   | ..|  |||
sllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 840-939 3.9e-08 27.2 In-house 147-242 (244) alignment 
Range on Protein: 840-939
Range on HMM: 147-242/244.0
IVVSRNFWKMIDDRNVTAIVMLCQEKENDlevcyQYWPSTSsGIILGEYNITL-LKENTSNRYI-ERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQ
   | .||||. .| |  .|.|   .|.|     .||| .   .   | .||. | .    . |   ..|..     ..|..| ||..|| | |   |  
adtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdse.plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndh

TI
 |
fi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 842-1008 1e-19 65.6 In-house 63-226 (239) alignment 
Range on Protein: 842-1008
Range on HMM: 63-226/239.0
VSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIilGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
 | .||.|. .     ||||    |   . |.|||| ..|     .  .|| | .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMYKtQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  .. | .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 842-1008 1.2e-19 65.5 In-house 64-227 (239) alignment 
Range on Protein: 842-1008
Range on HMM: 64-227/239.0
VSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIilGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
 | .||.|. .     ||||    |   . |.|||| ..|     .  .|| | .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMYKtQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  .. | .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 842-935 1.6e-07 25.7 In-house 40-129 (130) alignment 
Range on Protein: 842-935
Range on HMM: 40-129/130.0
VSRNFWKMIDDRNVTAIVMLCQEKENDlevcyQYWPStSSGIILGEYNITLL-KENTSNRYIE-RKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKN
 | .||||. .| |  .|.|   .|.|     .|||  |  .   | .|..   .    ..|.  ..|...    ..|..| ||..|| | |   |
tsmdfwkmmleryvnvlvvlgsveeed.....eywpd.sePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdgttpn
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 843-1008 1.5e-41 137.2 In-house 88-252 (283) alignment 
Range on Protein: 843-1008
Range on HMM: 88-252/283.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNT-NTGAKQSVTQFQVTNWDSTGEVKnPQTILM
 ..||||. |...|||||| . .|.  . | ||||.  | .  ||. .|| || ||| .| ... ...   . ..  .. .|| .| . ||   .   |.
vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslv

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl
subfamily_PTPN3_pd Subfamily PTPN3 843-1008 1.2e-30 101.4 In-house 97-261 (280) alignment 
Range on Protein: 843-1008
Range on HMM: 97-261/280.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMI
. .||.|. ..... |||| .  |.    |.||||.|.  . .||..... ||.... |. |.. .|...|  .....|.| ..|   |  .... .| .
atdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflef

IEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|.. ...|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.
verv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 843-1007 4.1e-27 89.9 In-house 105-264 (315) alignment 
Range on Protein: 843-1007
Range on HMM: 105-264/315.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTssGIILGEYNITLLKENTSNRYIERKFEVknTNTGAKQSVTQFQVTNWDsTGEVKNPQTILMI
 ..||... . ... |||| .  |.. . . .|||     .| |.. .|. .|.  ..|  | . |  .     . | |...| |  . .| .  . || 
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswp.dmgvpkytiplmn

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.    |  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||.
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqv
0036282 (Phosphotyrosine protein) phosphatases II 843-1007 2.3e-26 87.9 In-house 27-155 (174) alignment 
Range on Protein: 843-1007
Range on HMM: 27-155/174.0
SrnFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStssgiilgeynitllkentsnryierkfevknTNTGAKQSVTQFQVTNWDSTGEVKNPQtILMI
.  ||.|. . ..|..|||..|||..|. |..|||.                                . .  .... |.. ..|.  |.   .. .| .
a..fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.llef

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
...... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
vkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_PTPN9_pd Subfamily PTPN9 843-1007 2.8e-25 83.9 In-house 98-275 (297) alignment 
Range on Protein: 843-1007
Range on HMM: 98-275/297.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWP-STSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
...||.|. ...|  |||  .  |.    | |||| .. | .  |..... .. .... | .|..|.||..|. ...|| ||.. |   |  .. ...| 
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslld

IIEEMYKTQR---------KRG---NTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
..|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 843-1008 3.6e-20 66.9 In-house 103-267 (301) alignment 
Range on Protein: 843-1008
Range on HMM: 103-267/301.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENT--SNRYIERKFEVKNTNT-GAKQSVTQFQVTNWDSTGEVKNPQT
| .|| |.   .|  ||||.|. |.  |.| .| |..  . . .| ..|.. ....  ... ..|..||...    | ..|| .| ..|   |  |    
sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshae

ILMIIeEMYktqrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  .. |.     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.
lfdlm.elv....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn
0051082 (Phosphotyrosine protein) phosphatases II 843-1009 3.4e-17 57.9 In-house 22-140 (151) alignment 
Range on Protein: 843-1009
Range on HMM: 22-140/151.0
SRNFWKMIDDRNVTAIVMLCQEKENDleVCYQYWPSTSsgiilgeynitllkentsnryierkfevkntntgakQSVTQFQVTNWDSTGEVKNPQTILMI
.  |.... . ....||.|..|.|..   |..|.|...                                      |.......|. .|   .....| .
ladflellkelgiktivnlrseeerg..ycpeylpelg....................................ievlhipildwpdpglplsfdavlef

IEEMYKtqrkRGNTSIVVHCSDTVGRSAIFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVV
.|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.  
lellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq
subfamily_CG42327_pd Subfamily CG42327 843-947 3.9e-12 40.5 In-house 85-191 (319) alignment 
Range on Protein: 843-947
Range on HMM: 85-191/319.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG---IILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVtNWDSTGEVKNPQTI
| .||... ...   || |..  |. ..|| .|.|.  ..      |.. .|| . .. .||.   . .|. .    . .| .   .|  ..   .....
ssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaal

LMIIEEMY
. .. |. 
iamllevr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 843-1007 2.3e-06 21.5 In-house 95-261 (312) alignment 
Range on Protein: 843-1007
Range on HMM: 95-261/312.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNI------TL-LKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKN
. .||..      |.|..||   |.  | | .|     . . | .. .       . .  .. ..   | . |    || .  . ..| . |   |    
cthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds

PQTILMIIEEMYKTQRkrgntSIVVHCSDTVGRSAIFCAAA---TTINKCKTEGVIDVFQVLKSQRIQkpgSVQT
 .| | ..  . | ..      .. |||  |||.  ..      ... . . . | |.| .|. .| .   ||..
cdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar...svrv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 844-1009 2.4e-90 297.4 In-house 100-265 (287) alignment 
Range on Protein: 844-1009
Range on HMM: 100-265/287.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNTN-TGAKQSVTQFQVTNWDSTGEVKNPQTILMI
|||||.||||||||||||||||||| ||||||||...| ..||||||.||.|.... |||||.||||.| .|.||.|.|.|.|||||||.|..|||||..
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||| 
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 844-1009 1.3e-86 285.1 In-house 105-270 (290) alignment 
Range on Protein: 844-1009
Range on HMM: 105-270/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIiLGEYNITLLKENTSNRYIERKFEVKNTNT-GAKQSVTQFQVTNWDSTGEVKNPQTILMI
..|||.|....||.||||....|.. ..|.||||....   .||..|.||.|.| |.|||||.||||.|. ||||||||.|.|||||||.|.||||||..
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 844-1007 7.4e-48 158.3 In-house 103-268 (305) alignment 
Range on Protein: 844-1007
Range on HMM: 103-268/305.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLKENTSNRYIERKFEVKN-TNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
..||..| .  |. ||||.. .|.. . |.|||| . .    .||....|  |.| . |||||... .  .   ...|.|.|.|.|   | .. . ..| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|... |.|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... |||
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 844-1008 5.3e-44 145.1 In-house 99-279 (301) alignment 
Range on Protein: 844-1008
Range on HMM: 99-279/301.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKEN-----------------TSNRYIERKFEVKNTNtgAKQSVTQFQVT
..||..| .  ...|||....||.  . |.||||... .    |. ..|| .|.                 ..| ||||||.||...  . ..|.|.|||
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvt

NWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|   | |..|.|.|..|... ..|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.| 
dWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTL
Y_phosphatase Protein-tyrosine phosphatase 844-1008 1.9e-41 137.4 Pfam-A 56-223 (235) alignment 
Range on Protein: 844-1008
Range on HMM: 56-223/235.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWP-STSSGIILGEYNITLL-KEN-TSNRYIERKFEVKNTNTG-AKQSVTQFQVTNWDSTGEVKNPQTI
  ||.|. ...|..||||....|.. | | |||| ...     |.....|  ||.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYKTQrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... |.. .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 844-1008 1.9e-41 137.4 In-house 56-223 (235) alignment 
Range on Protein: 844-1008
Range on HMM: 56-223/235.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWP-STSSGIILGEYNITLL-KEN-TSNRYIERKFEVKNTNTG-AKQSVTQFQVTNWDSTGEVKNPQTI
  ||.|. ...|..||||....|.. | | |||| ...     |.....|  ||.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYKTQrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... |.. .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
DSPc_SM00195 844-1007 1.8e-40 134.3 In-house 83-247 (263) alignment 
Range on Protein: 844-1007
Range on HMM: 83-247/263.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSN-RYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
. ||.|. ...|. ||||..|.||. | |..|||..| .    |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
......|....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.|||
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
PTPc_SM00194 844-1007 1.8e-40 134.3 In-house 83-247 (263) alignment 
Range on Protein: 844-1007
Range on HMM: 83-247/263.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSN-RYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
. ||.|. ...|. ||||..|.||. | |..|||..| .    |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
......|....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.|||
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 844-1007 2.2e-39 130.4 In-house 103-265 (318) alignment 
Range on Protein: 844-1007
Range on HMM: 103-265/318.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
..||.|. ..| . |||| ||.|.  . . .||||  | . .|.  ..| .| ... |. |.|.|..|.. ... | |...|.|  .|  ... ..| ..
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 .  |.|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 844-1008 5.5e-35 115.8 In-house 66-228 (250) alignment 
Range on Protein: 844-1008
Range on HMM: 66-228/250.0
RNFWKMIDDRNVTAIVMLCQEKENDLEvCYQYWPSTSSGiILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
 .||.|. ......|||| . ||.. . . ||||   .  . |.  ..||....   |. ||. . ...   .. | |.. ..|   |  .. ...| ..
edfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLell

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
kkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 844-1010 1.4e-33 111.2 In-house 98-264 (281) alignment 
Range on Protein: 844-1010
Range on HMM: 98-264/281.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVkNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
 .||.|. ...|.||||. .| |..   |..|||  .| ...|.. .. ..|.....||||||.. ....| ...|.|.. |.|  .|  .... .|   
vafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefr

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVI
.|..|...|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   ||||| 
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 844-1007 1.3e-32 107.9 In-house 101-262 (315) alignment 
Range on Protein: 844-1007
Range on HMM: 101-262/315.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPS-TSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWDSTGEVKNPQTILMI
 .||.|. . .||.|||. . .|.|   | ||||   .  . .|.....||. ..    . ||. ......  .. ||||| |.|   |  |.  ..| .
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllkl

IEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. |..... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||
ikev.kadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt
subfamily_PTPRK_pd Subfamily PTPRK 844-1007 1.7e-31 104.2 In-house 100-262 (314) alignment 
Range on Protein: 844-1007
Range on HMM: 100-262/314.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGiiLGEYNITLLKENTSNRYIERKFEVKN--TNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
..||... | | ..|||| . .|.    |..|||  ..    |. ...|.. .. . .. | | |..   .  ... | ||| ..| . .  .. ...| 
kdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

IIEEMYKTQRKrGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. .. |.| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.|
lvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvet
subfamily_PTPN12_pd Subfamily PTPN12 844-1007 1.8e-31 104.1 In-house 97-262 (290) alignment 
Range on Protein: 844-1007
Range on HMM: 97-262/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGII-LGEYNITLLKENTSN-RYIERKFEVKNTntGAKQSVTQFQVTNWDSTGEVKNPQTILM
 .||.||.. ||. .||.|.| |..   | .|||..    .  ||...|| .|.. .  .. | ..|..   .....|.||. |.|   |  ......| 
ddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssakslle

IIEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQT
.||.. ..|. . .. .|||||  |||  . .|   . .  |.| .   .|||... . | |..  |||
lielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 844-1007 1.8e-31 103.8 In-house 100-261 (515) alignment 
Range on Protein: 844-1007
Range on HMM: 100-261/515.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPS-TSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWDSTGEVKNPQTILMI
 .||... . |||.|.|. . ||.|   | .|||   .  . .|.... |.  ..    | ||..|   .    . ||||. |.|   |  |. ...| .
ddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllkl

IEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. |... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||
ikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 844-1007 8.2e-31 102.2 In-house 106-269 (297) alignment 
Range on Protein: 844-1007
Range on HMM: 106-269/297.0
RNFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSSGIiLGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVK--NPQTILM
 .||.|. | .|..|||| ...|.|   | .||. ...   .|.  ..||  .  . .|.|..||.. .. |.. | |.| ..| .  . .  . ...| 
adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllk

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|.|. |.  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  |||
lisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt
subfamily_PTPN23_pd Subfamily PTPN23 844-1009 2.7e-30 100.2 In-house 97-267 (288) alignment 
Range on Protein: 844-1009
Range on HMM: 97-267/288.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMI
  ||.|. .. .  |||| ...| . . . .|||.        |....|| ...... ..||.....  .. |..||.  |.|.| . |  . |.|.| .
nDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqf

IEE---MYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVV
..|   .|...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||.. 
ldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 844-1007 2.1e-26 87.6 In-house 87-253 (274) alignment 
Range on Protein: 844-1007
Range on HMM: 87-253/274.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEY---NITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWDSTGEVKNPQTIL
 .||.||  ..|. |||| . ||.. . | .|.| . .  | ..|   .|.  | .. | |  ||. .|...   ..||. .  |.|  .   ....|.|
adfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantll

MIIEEMYKTQRKRGNT--SIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | |||
dlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt
subfamily_PTPN1_pd Subfamily PTPN1 844-1008 1.6e-25 84.4 In-house 85-257 (290) alignment 
Range on Protein: 844-1008
Range on HMM: 85-257/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS--GIILG--EYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTI
  ||.|. ...  |.||| .  |..   |.||||.  .   ..|   .....|..|.... |. |..|..| .|   .....|  | |   |  . |.. 
dhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaf

LMIIEEMYKTQR-KRGNTSIVVHCSDTVGRSAIFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTV
|  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .|| 
lkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
subfamily_PTPN13_pd Subfamily PTPN13 844-1007 2.9e-25 84.1 In-house 91-254 (273) alignment 
Range on Protein: 844-1007
Range on HMM: 91-254/273.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS-GIILGE-YNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
..||.|. ..... |.|. .|||..   | .|||.. .  . . . ....||| .  . .  |...||....|. . |.... ..|   |  .... .| 
kdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq

IIEEMYKTQRkrGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. |. . |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | |||
fvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 844-1009 7.8e-24 78.9 In-house 94-264 (287) alignment 
Range on Protein: 844-1009
Range on HMM: 94-264/287.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLK-ENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWdsTGEVKNPQ---TI
|.||... .......... .| |.    ||.|||     . .| | ..||. .. .  |  | . . . .|   . | |... .|    .|  |     |
rdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavgli

LMIIEE--MYKTQRK-RGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 ....     . .|.  .   .|||..  .||| |. |  . ... .  | .|| .|.   | .. . ||.||
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 844-1009 3.2e-23 77.1 In-house 78-251 (270) alignment 
Range on Protein: 844-1009
Range on HMM: 78-251/270.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG---IILGEYNITLLKENTSNRYIERKFEVKntNTGAKQSVTQFQVTNWDSTGEVKNP----
..||.|| ...||||||. . .|.  . | .|||. .     .  |. ... |.|. .. || .. ...  ..| .. .. |. ..|   | ....    
ksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedssl

--QTILMIIEEMYKTQRKRGN-TSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
  . .| ..... .....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||...
stdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe
subfamily_PTPN14_pd Subfamily PTPN14 844-1008 2.2e-22 74.4 In-house 107-282 (300) alignment 
Range on Protein: 844-1008
Range on HMM: 107-282/300.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPST---SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTIL
..||.|. . .|. |||| .|.|.  | ...|.|..    . .  |....|    ..|...| .....|   .. ...|  .| |.|   |  ..... |
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl

MIIEEMYKTQRKRGNTS--------IVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  .||.   .||  ...        ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||.
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
0051429 (Phosphotyrosine protein) phosphatases II 844-1009 2.4e-22 75.4 In-house 36-212 (272) alignment 
Range on Protein: 844-1009
Range on HMM: 36-212/272.0
RNFWKMiDDRNVTAIVMLCQEKENDLEVCYQYWP-----------STSSGIILGEYNITLLKENTSNRYIERKFEVKNT-NTGAKQSVTQFQVTNWDSTG
..||..  . ....||.|..| | . . |..|||           ..   | .| . .|||.| . . || |....... ..|.   |.... |.|   |
adfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

EVKNPqtILMIIEEMYKtqrkrgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVV
  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.|||  
vpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqtee
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 844-1008 3.9e-21 70.3 In-house 59-225 (237) alignment 
Range on Protein: 844-1008
Range on HMM: 59-225/237.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGA-KQSVTQFQVTNWDSTGEVKNPQTILMI
 .||.|. . . . ||||    |.. . |..|||||      | . ..| |..    |  | . . .  |    . . |.| | |   |  ..  ..| .
ddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrf

IEEMYKTQRKRGN-TSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  .. .  ..  . .  ..|||  |||..||    . . ..| . |.|... ..|   ..|  .|| 
rkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtk
0041856 (Phosphotyrosine protein) phosphatases II 844-1008 1.1e-19 66.1 In-house 48-157 (182) alignment 
Range on Protein: 844-1008
Range on HMM: 48-157/182.0
RNFWKMIDDRNVTAIVMLCqekendlevCYQYWPstssgiilgeynitllkentsnryierkfevkntnTGAKQSVTQFQVTNWDSTGEVKnPQTILMII
 .|..|. ....|.||.|.         ...|||                                   .  .. ..|.. ..|.  |    ....| .|
adflrmlkelgittivnlt.........eelywp...................................ellerlgiqylylpwpDhgvpd.ldelldfi

EEMYKtqrkrGNTSIVVHCSDTVGRSAIFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTV
||...      .  ..||||  |||.. ..||   . .    | .......|  | ..||.|.| 
eevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitp
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 844-1007 9.8e-19 62.1 In-house 108-268 (290) alignment 
Range on Protein: 844-1007
Range on HMM: 108-268/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLKENTS-NRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGeVknPQTILM
 ..|.|. . .|.||||||.  |.    | ||.| ..   . .||. ..  .|..  .. | . . |.. ..| .  .  ...  |     |  ... | 
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.v..alstla

IIEEMYKTQRKRGntSIVVHCSDTVGRSAIFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQT
..  ..  ..  |   .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .||| 
llrtlrilrkasG..pvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqv
0046846 (Phosphotyrosine protein) phosphatases II 844-1007 2e-18 62.2 In-house 37-158 (176) alignment 
Range on Protein: 844-1007
Range on HMM: 37-158/176.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIIlgeynitllkentsnryierkfevkntntgakqsvtQFQVTNWDSTGEVKNpQTILMII
 .|..|. . ..||.|.|..|.| .   |..|||   .  |                                    |.....|.  |     . .| ..
adflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl.elllell

EEMYKTQRKRgnTSIVVHCSDTVGRSAIFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQT
|.... ...     ..||||  .||.. ..||      ...|  ..|...|.  | |.| |.|||
efirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt
0044763 (Phosphotyrosine protein) phosphatases II 844-1006 3.3e-16 54.9 In-house 38-155 (178) alignment 
Range on Protein: 844-1006
Range on HMM: 38-155/178.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgiilgeynitllkentsnryierkfevkntntgakqsvTQFQVTNWDSTGEVKNPQTILMII
 ...... . ..|.||.|..|.|.  . |..|||.  .                                       |.. ....  |.   .. .| ..
addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhipipDhgvpdllehflefv

EEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKckTEGVIDVFQVLKSQRiqkPgSVQ
| . . .  . .  ..||||  ||||. ..||   .       . .... ....|   |  |.
efieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl..glsleeaielvrerR...p.ivp
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 844-1009 5.6e-15 49.7 In-house 105-266 (439) alignment 
Range on Protein: 844-1009
Range on HMM: 105-266/439.0
RNFWKMIDDRNVTAIVMLCQEKEndlevCYQYWPSTsSGIILGEYNITLLKENTSNRYIERKFEVKNTNTG--AKQSVTQFQVTNWDSTGEVKNPQTILM
 .||... ..... ||||..  |      |.||||  . .. |.  .   ..    .|. | | | |       ...| ||. . |       .   .| 
ddfwrlviekktvtivmltnlve.....sykywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 844-1007 2.8e-14 47.3 In-house 105-273 (302) alignment 
Range on Protein: 844-1007
Range on HMM: 105-273/302.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITLLKENTS-NRYIER------KFEVKNTN--TGAKQSVTQFQVTNWDSTGEV
  .| .|.. ||. .| ||. .|.. . | .|.     |   .|.| .. .. .|  ... ..      . |.||..  .  |..|  .. . |   |  
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGap

KNPQTILMIIE--EMYKtqrkrgnTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|...| | |.   | ||       ....||||  |||.  . |    |. |... | |. ....  |  . |.||.
keaytaldilkfcesyk.......knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 844-1008 9.8e-14 45.7 In-house 95-255 (281) alignment 
Range on Protein: 844-1008
Range on HMM: 95-255/281.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERkFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
 .||.|| . | ||||||||  | . | | .|.|  .   .  .      .. | |. .     .. .  |  . .|..   .|      .  . .| |.
adfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvt.trlnlsyegetrlithwlwkewpdwqvpessevmlkil

eemyKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTV
    .  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||.
....rkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtl
subfamily_hpo-7_pd Subfamily hpo-7 844-979 1.9e-13 44.9 In-house 48-178 (263) alignment 
Range on Protein: 844-979
Range on HMM: 48-178/263.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLkeNTSNRYIERKFEVKNTN--TGAKQSVTQFQVTNWDSTGEVKNPQTIL
 .|...|   . . .||||  .|.. | | .|.|    .  .| . |..    .. .  . .  |. .|       . |.... . |  . ...... ||
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvctt..kvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

MIIeemyKTQRKRgnTSIVVHCSDTVGRSAIFCAAATTI
 |.    |  |.    |.|||||  .|||| |  | .  
nil....kvarns..kslvvhcstGiGrsaafsvaElvy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 844-1007 3.5e-13 44.2 In-house 96-262 (307) alignment 
Range on Protein: 844-1007
Range on HMM: 96-262/307.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS-GIILGEYNITLLKENTSNRYIERKFEVKN------TNTGAKQSVTQFQVTNWDSTGevkNP
 .|| |. . .| ...|||.  |     | ||||       . || . |.  .|   . .    .. |        ..  ......| .||   |    |
ysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vp

QTILMIIEEMYKTQRKrgNTSIVVHCSDTVGRSAIFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQT
|. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||
qinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 844-1008 8e-13 43.0 In-house 96-257 (288) alignment 
Range on Protein: 844-1008
Range on HMM: 96-257/288.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTsnRYIERKFE---VKNTNTGAKQS-VTQFQVTNWDSTGEVKNPQTI
 ..|||. . .|  |||||.  |  .|   .|.||     .    . |  |..     |..  .   ......| ..  | .  . .||  |  .| .. 
eelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsp

LMIIEEMyktqrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..|| 
lrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqte
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 844-1005 2.2e-11 38.3 In-house 18-186 (198) alignment 
Range on Protein: 844-1005
Range on HMM: 18-186/198.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITLLKENTSNRYIERKFEVKNTNT--GAKQSVTQFQVTNWD--STGEVKNPQT
 .||.|. .     |||. ... |       |||.| ||    |  ..|     |   |    . . |  |   . . ....| | |   .| .|     
adfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvg

ILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSV
...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | .
fvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgii
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 844-1005 2.3e-11 38.2 In-house 19-187 (199) alignment 
Range on Protein: 844-1005
Range on HMM: 19-187/199.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITLLKENTSNRYIERKFEVKNTNT--GAKQSVTQFQVTNWD--STGEVKNPQT
 .||.|. .     |||. ... |       |||.| ||    |  ..|     |   |    . . |  |   . . ....| | |   .| .|     
adfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvg

ILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSV
...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | .
fvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgii
subfamily_egg_pd Subfamily egg 844-1010 7.3e-10 33.0 In-house 97-258 (307) alignment 
Range on Protein: 844-1010
Range on HMM: 97-258/307.0
RNFWKMIDDRNVTAIVMLCQEKENdlEVCYQYWPSTSS-GII--LGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTIL
 .||.|.   .|  ||||   ||.  | |  ||| . |  ..   | ..|. || .     . |  ..|   .  ..   .    ... ...|  |  .|
ddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl

MIIEEMyktqrkrgNTSIVVHCSDTVGRSAIFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVVI
  . ..         . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|. 
rklrnl........skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 844-1008 2.3e-07 24.5 In-house 107-271 (302) alignment 
Range on Protein: 844-1008
Range on HMM: 107-271/302.0
RNFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSSG-IILGEYNITLLKENTSNRYIeRKFEVKNTNTGAKQSVT--QFQVTNWDSTGEVKNPQTIL
 .||.|. ..... .|.| .|.| .     ...| .|      |.  .   | . ..     .. .     |  .||      .||| ..   ..  .. 
eeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli

MIIEEMYKtQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  ...... .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|...
ktaakvfa.kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl
subfamily_PTPRD_pd Subfamily PTPRD 845-1007 1.8e-43 144.1 In-house 106-266 (564) alignment 
Range on Protein: 845-1007
Range on HMM: 106-266/564.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. ..|.. |||| . .|.. . | .|||...     ||. .|| .|.. . |. |.|..|....  .. |.||. |.| ..|  ......| .|.
dFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

EMYKTQrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
kvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 845-1007 1.1e-39 131.4 In-house 114-275 (298) alignment 
Range on Protein: 845-1007
Range on HMM: 114-275/298.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGiILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. ......|||| . .| |   . .|||.. .    || ...||....   .| ||..|.....  ...| |...|.| . |. .| ...| ...
dFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

EMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.|||
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt
subfamily_PTPRA_pd Subfamily PTPRA 845-1008 2.8e-34 113.5 In-house 116-281 (330) alignment 
Range on Protein: 845-1008
Range on HMM: 116-281/330.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVK----NTNTGAKQSVTQFQVTNWDSTGEVKNPQTIL
.||.|| ... ..|||| . || . | |.||||.  . .  |. .... .|. .. |  ||| |.    .|.  ... |.||  | |   |   .|. .|
dfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGml

MIIEEMYKTQRKRGNtSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..... |.... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  ||| 
kllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 845-1007 1e-32 108.5 In-house 106-268 (319) alignment 
Range on Protein: 845-1007
Range on HMM: 106-268/319.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNTNTGA-KQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|. ....  .|||.. .|.    . .|||..      |.. .||..|.  . || ||..... ..     .|..|| |.|   .  .. ...| ..
dfWrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
... |...|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqr
subfamily_Ptp69D_pd Subfamily Ptp69D 845-1007 2.4e-31 104.0 In-house 106-271 (307) alignment 
Range on Protein: 845-1007
Range on HMM: 106-271/307.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTsSGIILGEYNITLLKENTSNRYIERKFEVKNTN-----TGAKQSVTQFQVTNWDSTGEVKNPQTI
.||.|| . .|| |||| ...| . . | .|||     .  |. ...| .|.. . ||.|...| ...       ... |.|.. |.|. .   . ....
DfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

LMIIEEMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| .||.... ...  .. ||||||  ||||.|| | .  ....|.|  .|.|.. |  | |..  || 
lklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs
subfamily_PTPRB_pd Subfamily PTPRB 845-1009 3.2e-31 103.5 In-house 109-272 (293) alignment 
Range on Protein: 845-1009
Range on HMM: 109-272/293.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNtnTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. ......|||| |  |.  . | .|||.... .. |. ..||..|.. . .. |......  . ....|.|.. | |   |  ....|.| ...
dfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvr

EMYKTQ-RKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.. ... ..  .. ||||||  |||. .| |  . ... ..| ..|.| .. . | ..   |||. 
tvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 845-1008 1.8e-30 101.0 In-house 105-265 (288) alignment 
Range on Protein: 845-1008
Range on HMM: 105-265/288.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKntNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||... ..... |||| .  |.. . | .|||..      |. ..||..... . ...||....   .. .  .||.| . |  .|  .. . .| ...
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr

EMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 . |.. .     |.||||. |||. .| |. . |.. ..| .|||. ...  | |..  |||.
qv.kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtl
subfamily_PTPN6_pd Subfamily PTPN6 845-1008 3.4e-30 100.1 In-house 113-283 (306) alignment 
Range on Protein: 845-1008
Range on HMM: 113-283/306.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVK-NTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|. . | . |||. .| |   | |..|||....    |....| ..|.. ..|| |.. |. ... . ...| |.. ..|   |  |.|...|  .
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMYKTQRKRG---NTSIVVHCSDTVGRSAIFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
|.. . |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| 
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 845-1008 4.1e-29 96.7 In-house 106-274 (325) alignment 
Range on Protein: 845-1008
Range on HMM: 106-274/325.0
NFWKMIDDRNvTAIVMLCQEKENDLEVCYQYWPST-SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
..|... | . ...|..  | ... . | .|||   .    .|  .. |   ..   |. |...||... |  .|| |||.  ||  |  | | |.. |.
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

EEM---YKTQR--KRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .    .. .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.||
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv
subfamily_PTPRG_pd Subfamily PTPRG 845-1007 6.5e-29 95.6 In-house 106-272 (563) alignment 
Range on Protein: 845-1007
Range on HMM: 106-272/563.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQS------VTQFQVTNWDSTGEVKNPQT
 ||.|| ..||. |||. . .|.  . | .|||.    . .|. ..|| .|..   | .|.. .||..  .|..      |.|.. |.|  .|  . .  
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

ILMIIEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |. ..   .... .    ||||||  |||. ....  | ... ..| ...||..||  | |..  |||
vLifvkkssaank.aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 845-1009 2.8e-27 90.9 In-house 119-278 (319) alignment 
Range on Protein: 845-1009
Range on HMM: 119-278/319.0
NFWKMIDDRNVTAIVMLCqekendLEVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKN-TNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|| . |...||.|        . | ||||     |  ..... .   . .. |. |..|. . ..   ....|||    |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

EE-MYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 845-1009 4.1e-27 90.4 In-house 83-242 (284) alignment 
Range on Protein: 845-1009
Range on HMM: 83-242/284.0
NFWKMIDDRNVTAIVMLCqekendLEVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKN-TNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|| . |...||.|        . | ||||     |  ..... .   . |. |. |..|. . ..   .....||    |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlv

EE-MYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|
kkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv
subfamily_PTPRN_pd Subfamily PTPRN 845-1007 1.8e-26 87.5 In-house 115-277 (297) alignment 
Range on Protein: 845-1007
Range on HMM: 115-277/297.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIiLGEYNITLLKENT-SNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|. .. |. ||.|.. .|.... |..||| . | .  . |.. |. |   .. |. | | .|| .|   ..||||    | ..|   .....|   
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr

EEMYKTQRKRGnTSIVVHCSDTVGRSAIFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQT
  . |. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|
rkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt
subfamily_CG7180_pd Subfamily CG7180 845-1007 1.4e-22 74.8 In-house 100-275 (296) alignment 
Range on Protein: 845-1007
Range on HMM: 100-275/296.0
NFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKNT-------NTG---AKQSVTQFQVTNWDSTGEVK
.||... |... |.|.|... .     . .||| .|     ||  . ...|..      |.| .. .       ...    .  |..||.| |..  .| 
efWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP

NPQTILMIIEEMYKTQRKRG-----NTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
   . |. . .. .. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..
lstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 845-1008 2.2e-21 71.0 In-house 87-245 (267) alignment 
Range on Protein: 845-1008
Range on HMM: 87-245/267.0
NFWKMIDDRNVTAIVMLCQEKENDLEvcyQYWPST-SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKqSVTQFQVTNWDSTGEVKNPQTilMII
.|...| |..|. ||.| .  ....    ..||          .  .    |.  | |    .|.|  |  |.  || .   .|.   . |       ..
dfltvihdqkvpvivlltkvftdnir...lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkwnintnnkpylk..plf

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  . | | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
gilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
0049260 (Phosphotyrosine protein) phosphatases II 845-1007 4.3e-20 67.4 In-house 24-135 (152) alignment 
Range on Protein: 845-1007
Range on HMM: 24-135/152.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWpstssgiilgeynitllkentsnryierkfevkntntgakqsvtQFQVTNWDSTGEVKNPQTILMIIE
.||.|. . ..|.||||... |.. . |.||.                                            |.. ..|.  |  ...| .|....
dfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllflll

EMYKTqRKRGNTSIVVHCSDTVGRSAIFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQT
 . |  ... .  ..||||  |||.. ..||   .        ........  | ..||.|..
fiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn
0043147 (Phosphotyrosine protein) phosphatases II 845-1007 9.1e-19 63.3 In-house 35-146 (172) alignment 
Range on Protein: 845-1007
Range on HMM: 35-146/172.0
NFWKMIDDRNVTAIVMLCQEkendlevcyqywpstssgiilgeynitllkentsnryierkfevKNTNTGAKQSVTQFQVTNWDSTGEVkNPQTILMIIE
 ||.|. ....|.||.|...                                             .. .. .... |.. ..|.  |   ... .| ..|
dfwrmlkelgithivnltel............................................lydpellerlgiqylylpwpDhgvp.llelllefle

EMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQT
 ... . .. .  ..||||  |||.. ..||   .        . .......  | ..||.||.
fidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 845-999 8.9e-15 49.6 In-house 82-236 (290) alignment 
Range on Protein: 845-999
Range on HMM: 82-236/290.0
NFWKMIDDRNVTAIVMLCQEKENDLE----VCYQYWPSTSSG-IILGEYNITLLKENTSNRYIERKFEVKNtNTGAKQSVTQFQVTNWDSTGEVKNPQTI
.|| |. . .|. .||||. .|.. .     | .| | .  . . ..  ..   .  . .  ..|. .||  . . .  ||  .. .|...   ....|.
kfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktl

LMIIEEMYKTqrkrgNTSIVVHCSDTVGRSAIFCAAATTINKCK-TEGVIDVFQVLKSQRI
| .|. . .      .| ..||| | . |||.. |      |   |.| . . .|||. | 
lsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 845-1007 2.8e-13 44.5 In-house 90-255 (285) alignment 
Range on Protein: 845-1007
Range on HMM: 90-255/285.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITL--LKENTSNRYIERKFEVKNTNTGAKQS--VTQFQVTNWDSTGEvknPQTI
.||.|| . ... ..|||   |  .| |  |.|     .  .|.|.|||   ||..    |   . | ||.  . .   . . ||  |        |.  
dfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla...peda

LMIIeEMYKTQRKR--GNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  .| |.||  .|    .. |.||||  |||.| |     .  .   .  |.......  |  .  .||.
rpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 845-1009 6.8e-12 39.6 In-house 111-276 (305) alignment 
Range on Protein: 845-1009
Range on HMM: 111-276/305.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGiILgEYNITLLKENTS-NRYIERKFEVKNTN------TGAKQSVTQFQVTNWDSTGEvknPQ
.|| |. ...|  |||||.  |     | |||| .     | | .  .. || | .. .||  |.. |        . | || ..| |.|   |    | 
efwwmviqnkveqivmlcktvelgklkcaqywpaaqge.kl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...pp

TILMIIEEMYKTqRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVV
  |  .| .    |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. |
ckltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndv
subfamily_ptpA1_pd Subfamily ptpA1 845-982 3.2e-10 34.3 In-house 104-256 (418) alignment 
Range on Protein: 845-982
Range on HMM: 104-256/418.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG----------IILGEYNITLLKENT-SNRY-IERkfEVKNTNTGAKQSVTQFQVTNWDSTGE
.||.|. .  .  |||| .| ||    | .|||    |           ..| |.. |..     .|  | |  ... |  |  . .||.|   |     
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfegetrditqyqyegwpdhni

VKNPQTILMIIEEMYKTQRK-----RGNTSIVVHCSDTVGRSAIFCAAATTINKC
    | .  ..  . . | .       |  |.||||  |||.  ||.|   ..| 
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 845-1007 4.1e-09 30.6 In-house 103-272 (305) alignment 
Range on Protein: 845-1007
Range on HMM: 103-272/305.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIIL---GEYNITLLKENTSNRYIER--KFEVKNTN------TGAKQSVTQFQVTNWDSTGev
.|| |  . .| || |||. .|   . |..|..|    ..    ..  |..  | ...  ...  | .|..|        . .. ||..   .|   |  
dfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg..

kNPQTILMIIEEMYKTQRKRGntSIVVHCSDTVGRSAIFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQT
  | . | |.| . |..  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.||
.vpaadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 845-1011 1.2e-08 28.9 In-house 109-279 (310) alignment 
Range on Protein: 845-1011
Range on HMM: 109-279/310.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIE---RKFEVKNT---NTGAKQSVTQFQVTNWDSTGEVKNPQT
.||.|| .    .|..||.  |.    |  ||||       |   .| | | . .  |      |   |    .  |.    . .. .|    .   |. 
dfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde

ILMIIEEMYKTQRKRGNtsIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVIH
    . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| . .
kchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy
subfamily_eak_pd Subfamily eak 845-934 3.6e-07 23.9 In-house 108-196 (332) alignment 
Range on Protein: 845-934
Range on HMM: 108-196/332.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSNRYIERKFEVKNTNTGakQSVTQFQVTNWDSTGEVK
 ||.|. ...  |||.| .. |..||   .|.|  .   .  | ....  .    | .  |..|..  |      |  ..|  |  |   |
afwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlpk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 845-884 6.1e-07 23.6 In-house 91-130 (297) alignment 
Range on Protein: 845-884
Range on HMM: 91-130/297.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGII
.||... ...| .|||... .|.  . |. ||||.  .  
dfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 845-881 1.1e-06 22.7 In-house 119-155 (350) alignment 
Range on Protein: 845-881
Range on HMM: 119-155/350.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS
.|.|.|   .|. |..| .. |..|| ||.||.  | 
dfykvillnkvkvilsltsdvelnlekcyrYWqegsy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 845-928 3.2e-06 20.7 In-house 251-329 (440) alignment 
Range on Protein: 845-928
Range on HMM: 251-329/440.0
NFWKMIDDRNVTAIVMLCQEkeNDlEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWD
.||... | ....|.|| |   ||   |  |||  .  . .| . .     .  ||   | .|.|  .    . . ||.|  | 
dfwrlvhdyristiimlnql..nd.ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee..vheirqfevqtwp
0048179 (Phosphotyrosine protein) phosphatases II 849-1008 2.4e-11 39.1 In-house 24-131 (144) alignment 
Range on Protein: 849-1008
Range on HMM: 24-131/144.0
MIDDRNVTAIVMLCQEKENDLEVCYqywpstssgiilgeynitllkentsnryierkfevkntntgakqsVTQFQVTNWDSTGEVKNPQTILMIIEEMYK
.. . ..|... |. | |.. . ..                                             ..|.. ..|.  |    .. .| ..| . .
llkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefiee

TQRkrGNTSIVVHCSDTVGRSAIFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTV
 ..   .  ..||||  |||.. ..||   .    ..| ......|.  | . ||.|.. 
ale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp
0048076 (Phosphotyrosine protein) phosphatases II 875-1008 3.1e-12 41.9 In-house 2-129 (145) alignment 
Range on Protein: 875-1008
Range on HMM: 2-129/145.0
YWPST-SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKrgNTSIVVHCSDTVGRSAIFC
||||    |. || .  .|  |.  .  | . . . .. .. .. ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.. ..
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv

AAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTV
||   .     .| ......|.  | | ||.|...
aaylmll....lg.vsleealelvrsqrpgavpnp
Filo_glycop Filovirus glycoprotein 894-960 5.1e-06 13.3 Pfam-A 192-260 (364) alignment 
Range on Protein: 894-960
Range on HMM: 192-260/364.0
KENTSNRYIERKFEVKNTNTGAKQSVTQFQV--TNWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVV
.|.....|.  . | . ...|...| . |.|  |..    . . ||... . |....|...   |  ..
tedstskYatstleyevedfGteeseiLfevdnttyvqlersltPqfLvqlnetikltnkrsnttgkli
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 908-975 2.8e-07 24.6 In-house 207-282 (350) alignment 
Range on Protein: 908-975
Range on HMM: 207-282/350.0
VKNTNTGAKQsVTQFQVTNWDSTGEVKNPQTILMIIE---EMY-------KTQRKRGnTSIVVHCSDTVGRSAIFCAA
.. . .     | |.|| ||   . . ||. || ..|   ..          . .|. ..|.||||  |||  .... 
itlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 917-1008 5.5e-11 36.5 In-house 89-180 (440) alignment 
Range on Protein: 917-1008
Range on HMM: 89-180/440.0
QSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... |..   |   |  |    .| .|... ..| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp
PTPc_DSPc_SM00012 919-1007 4.7e-19 63.9 In-house 2-92 (105) alignment 
Range on Protein: 919-1007
Range on HMM: 2-92/105.0
VTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKRG-NTSIVVHCSDTVGRSAIFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQT
|.....|.|  .|  .... || ..... | ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 945-1008 6.5e-06 20.2 In-house 219-281 (297) alignment 
Range on Protein: 945-1008
Range on HMM: 219-281/297.0
EMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| ....  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl