Gene PTPRD-34 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP089_AA protein Get Run
AqueP089_AA_1721-1874 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 432-510 1.3e-11 37.7 Pfam-A 3-85 (85) alignment 
Range on Protein: 432-510
Range on HMM: 3-85/85.0
VSNIMFASVSSVSMNVSWSEVPcdGRNGPITGYYLTYNSN------IVNITEGDKRTHIFRDLSPYTNYTMSIVPYNAVGMGPPS
..|. . .|.| |...|||. .   ..|||||| ..| .           ............| |.|.|....  .|..| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 532-604 2.1e-12 40.2 Pfam-A 10-84 (85) alignment 
Range on Protein: 532-604
Range on HMM: 10-84/85.0
DFSPYLLSMVWNPPTIPNGIITVYEIRYGESTSTG---PYNVTNTTNtYYSIAGLIPNTSYTIGVRAYTSIGPGEW
. ..  |.. |.||. ..| || ||..| |.....    ..|..||.  . . || |.|.|.. |.|..  | |..
evtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 616-696 1.5e-10 34.2 Pfam-A 2-85 (85) alignment 
Range on Protein: 616-696
Range on HMM: 2-85/85.0
SVQGLMVIPLNASSVHVSWVLPD--ISPISYYTLYYNKSTDD--VFSVNVSNTSTHAVVTGLtGSSTEYGFRISVTIGDFEGQLS
....| |.. ...|...||  |.   .||..|.. | ....     ...|..|.|....|||   .||| ||.    |. ||. |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgL.kpgteYefrVqavngagegpeS
Ig_2 Immunoglobulin domain 717-783 3.6e-07 22.1 Pfam-A 12-67 (80) alignment 
Range on Protein: 717-783
Range on HMM: 12-67/80.0
SIGESYNMTCIVSvldlLIPSTIIQWSKtpPNDTLPSLSNGettsiHYIKSLNTSDAGQYTCTATVS
. ||. ..|| ..      | . .||.|   ...|..  |.      .|.... .|.|.|||.|. |
tegenvtLtCqap....gnptpkvqwyk..dgeelsqsqna.....lfipnvsaedsGtYtCrasns
Ig_2 Immunoglobulin domain 809-911 5.2e-08 24.8 Pfam-A 5-80 (80) alignment 
Range on Protein: 809-911
Range on HMM: 5-80/80.0
NLSFsrvTDLLAGSSLNLTCSFSLDPRIDtpvtimTVWTRGSNLFSANERViidnssslqsvVYFTLLSANDTGYYQCKVdfipvSNFVTnsSNVSSTIY
. ..   | . .|....|||... .|  .        |.......| ...            ..  ..||.| | |.|..     ||  .  |..|... 
sapp...tvvtegenvtLtCqapgnptpk......vqwykdgeelsqsqna...........lfipnvsaedsGtYtCra.....snseg..skqsnsve

LNV
..|
vtv
Ig_2 Immunoglobulin domain 939-1008 6.7e-07 21.3 Pfam-A 14-68 (80) alignment 
Range on Protein: 939-1008
Range on HMM: 14-68/80.0
YDNFTLTCTATK-PAIVlselmLVWTHNGagrdGIIAttgSSNNIktntLTVSNTSINDAGYYRCNATLNV
 .|.||||.|.  |. .     . |...|     ..    .| |.    | ..|.| .|.| |.| |..  
genvtLtCqapgnptpk.....vqwykdg....eels...qsqna....lfipnvsaedsGtYtCrasnse
ig Immunoglobulin domain 941-1003 6.8e-09 27.0 Pfam-A 3-63 (64) alignment 
Range on Protein: 941-1003
Range on HMM: 3-63/64.0
NFTLTCTAtkpAIVLSELMLVWTHNGAGRDGIIATTGSSNNIKTNT-LTVSNTSINDAGYYRCN
..||||..        .    |...|.|.     | ...|. . .. ||..|.. .|.|.|.| 
svtLtCsv...ssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv
fn3 Fibronectin type III domain 1134-1212 4.8e-13 42.2 Pfam-A 2-84 (85) alignment 
Range on Protein: 1134-1212
Range on HMM: 2-84/85.0
APLNCTVSNIESDAVDLYWSPPDklLQNGRIMSYNVSCSFVGNNS----FDTVDTE--LFISDLDPYTTYTCNVSAVNKVGGGPA
|| | .||.. |. . | ||||.   ..| | .|.| .. .|...    |..  |.  . ...| |.|.|...| |||..|.||.
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 1228-1310 1.4e-06 21.5 Pfam-A 3-83 (85) alignment 
Range on Protein: 1228-1310
Range on HMM: 3-83/85.0
PRNF-ISTPNKTFIFFHWMAPELPNGVIIHYNLTVTNLDRANttvSIINVTDSSDIIESLITGFSPYQNYTASVSASTIIGTGP
|.|. .|  . | . ..| .|. ..| | .|.... . .  .      ..| ...  .  .||  |...|. .| | .  |.||
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 1344-1418 7.6e-13 41.6 Pfam-A 8-83 (85) alignment 
Range on Protein: 1344-1418
Range on HMM: 8-83/85.0
VPSINDTAVNITWRPPLYPNGRITGYNVTNDNNGRS-YWIPMMSVESVYSYTITELNIGELYNFTIRAFNDLGGGE
| ....| ....| ||  ..| ||||.|.  . | . .|      .. .|.|.|.|. |  |.|...| |. |.|.
vsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 1445-1513 1.3e-08 28.0 Pfam-A 12-75 (85) alignment 
Range on Protein: 1445-1513
Range on HMM: 12-75/85.0
DKTTITVNWDSKTfDGVGAFFAYKVTATTTSTRKrqsgSPIEMIVPYNTTSVSLTGVNPNLTYQITVSY
  |..|..|.  . || | .  |.|.  .... .     . |  || .|||| ||| .|. .|...|  
tstsltlsWsppk.dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqa
0045450 (Phosphotyrosine protein) phosphatases II 1714-1874 1.3e-35 119.1 In-house 4-220 (307) alignment 
Range on Protein: 1714-1874
Range on HMM: 4-220/307.0
NEFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSG---APYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD----SDYINACFV--------DGY
.  ..| . .. ..||... .. . .  ||...         .|.......|..|||. .|.||| ||| |..  .    |||||| .|        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

ARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVY-----------------------------------------DAWEEVGRKVSLLC
 .|. .||.||||  ||.|||.|.||.. ..|||||. .| |..                                             |.   ..    
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

EWLGHDLPHTLWPILEL
.| .|..| .. ..|..
gwpdhgvppsfeelldf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1715-1809 9e-67 215.4 In-house 1-95 (95) alignment 
Range on Protein: 1715-1809
Range on HMM: 1-95/95.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRDSDYINACFVDGYARKNCYIAAQG
|||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||
efkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_PTPRB_pd Subfamily PTPRB 1715-1842 2.5e-38 126.8 In-house 3-134 (293) alignment 
Range on Protein: 1715-1842
Range on HMM: 3-134/293.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSISM-TSGAPYTAGSSEANIPKNRFLNIFPYDATRVAL---TTKRDSDYINACFVDGYARKNCYIAAQGP
. |||... |..|| .|...|| .| .|.....   .    .| ....|  |||. || |||..|| |   .....|||||| ...||  .. .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV
|  ||||||.|.||.| . ||||| ..| |||
lpetvddfWrmvwekkssiivmltqlvekgkv
0039614 (Phosphotyrosine protein) phosphatases II 1715-1867 4.4e-36 120.3 In-house 10-201 (297) alignment 
Range on Protein: 1715-1867
Range on HMM: 10-201/297.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGaPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD----SDYINACFVDGYAR-KNCYIAAQG
|. ||..||.. ..| .. || . ...||...      .|. . ...|..|||. .|.||| .|| |.....    |||||| .|||| . .. .||.||
esipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK-------------------VYDAWEEVGRKVSLLC----------------EWLGHDLPHT
||  ||.|||.|.||.. ..|||||  .| |.                   . .  .. | .|  |.                 |  |. |..
PlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvpps
subfamily_PTPRA_pd Subfamily PTPRA 1715-1841 5.6e-34 112.5 In-house 10-142 (330) alignment 
Range on Protein: 1715-1841
Range on HMM: 10-142/330.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSISM-TSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGP
.. |. |  .   .    ..  . | .||...   .  | . . | | |  |||..||.||| .|| |..|.   .|||||| |.||| .|. .||||||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

LRRTVDDFWHMIWEHKLNHIVMLTGIIEAG--K
...||.||| ||||.|   ||||| . |    |
keetvedfwrmiweqksativmltelkerkeek
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1715-1839 8.8e-25 82.4 In-house 6-129 (297) alignment 
Range on Protein: 1715-1839
Range on HMM: 6-129/297.0
EFKPIHVSVFHSHVLEmhSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTK---RDSDYINACFVDGYARknCYIAAQGPL
| .|| .| | . | .  . . . | .||. .  .   | |      |..|.|. || |||  || |       ||||.|| || |.     .|. | | 
errpiplsdfatlvqk..nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

RRTVDDFWHMIWEHKLNHIVMLTGIIEA
. ||.||| |..... . ||||.   | 
katvadfWamvldeqvstivmlnddner
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1716-1841 9.4e-29 95.3 In-house 3-131 (315) alignment 
Range on Protein: 1716-1841
Range on HMM: 3-131/315.0
FKPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVAL---TTKRDSDYINACFVDGYARKNCYIAAQGPLR
..|| .  . ..| . .... . | ....||      |        |  |||. || .|| .|| |    .. .|||.|| |.|||..|. |||||||. 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

RTVDDFWHMIWEHKLNHIVMLTGIIEAGK
 .|.||| ...|... .|||||...|  |
asvkdfwrlvfeedigkivmltnlvegek
subfamily_PTPRD_pd Subfamily PTPRD 1717-1842 2.8e-48 159.9 In-house 3-131 (564) alignment 
Range on Protein: 1717-1842
Range on HMM: 3-131/564.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALT---TKRDSDYINACFVDGYARKNCYIAAQGPLRR
|||.|. ...|| ....|||..|..|.|.|.. .  . .| . .|| .|||. || .||..|| |.    . .|||||| |.||| ... |||.|||| .
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVDDFWHMIWEHKLNHIVMLTGIIEAGKV
|..||| |.||.. . ||||| . | |||
tiedFWRmvweqnsstiVmltkleEkgkv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1717-1842 1.3e-38 127.8 In-house 3-131 (319) alignment 
Range on Protein: 1717-1842
Range on HMM: 3-131/319.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFVDGYARKNCYIAAQGPLRR
..|.|  ..... ...|.... ...||| .....   ..  | | | .|||. || .|| |||.|..   . .|||||| |.||| ... .||.|.||  
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TVDDFWHMIWEHKLNHIVMLTGIIEAGKV
|..||| |.||..   .||||.. | .||
tiedfWrmvWeeessivvmltklveklkv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1717-1841 5.1e-37 122.6 In-house 2-128 (305) alignment 
Range on Protein: 1717-1841
Range on HMM: 2-128/305.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTsGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRDS---DYINACFVDGYARKNCYIAAQGPLRR
|.| .. ..... |....||.......||. .. . ..  |..|||  |||. .|...|  |. ||.| .    |||||..|||| ||..||.|||||. 
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TVDDFWHMIWEHKLNHIVMLTGIIEAGK
||.|||..|.| | ..|||||...| ||
tvadfWrliveekvstivmltklveggk
0050432 (Phosphotyrosine protein) phosphatases II 1717-1843 2.8e-36 120.8 In-house 24-151 (308) alignment 
Range on Protein: 1717-1843
Range on HMM: 24-151/308.0
KPIHVSVFHSHVLEmhSNSDQEFDNEFKSISMTSG-APYTAGSSEANIPKNRFLNIFPYDATRVALttKRDSDYINACFVDGY--ARKNCYIAAQGPLRR
....|  .. .. .   .. . .. ||. . ..    .|.... ..|..|||. .|.||| .|| |  . .|||||| .||||   ... .||.||||  
lklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpn

TVDDFWHMIWEHKLNHIVMLTGIIEAGKV--Y
||.|||.|.||.. ..||||| ..| |..  .
tvedFwrmvweqnvrvIvmLtklvengrekca
0051299 (Phosphotyrosine protein) phosphatases II 1718-1873 3.5e-38 127.1 In-house 4-206 (288) alignment 
Range on Protein: 1718-1873
Range on HMM: 4-206/288.0
PIHVSVFHSHVLEMHSNSDQEFDNEFKSISMTS-GAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD---SDYINACFVDGYARKNCYIAAQGPLRR
.|.|. ....||... |.   . .||. .       ...|.. ..|..|||. .|.||| .|| |..  .   |||||| ..||| .|. .||.||||  
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVDDFWHMIWEHKLNHIVMLTGIIEAGKVY-------------------------------------DA----WEEVGRKVSLL--CEWLGHDLPHTLWP
||.|||.|.||.. ..|||||...| |..                                      .     ...  |.|  .    |  |. |... .
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

ILE
.|.
lld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1718-1841 7.3e-35 115.4 In-house 3-129 (288) alignment 
Range on Protein: 1718-1841
Range on HMM: 3-129/288.0
PIHVSVFhSHVLEMHSNSDQEFDNEFKSI-SMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFVDGYARKNCYIAAQGPLRR
|||.|   ..| ... .. ..| .|..|. .. .    |||.   | .|||. || ||| .|| |.    ....||||| ..||. .|. |||.||||  
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPlad

TVDDFWHMIWEHKLNHIVMLTGIIEAGK
||.|||....|.| . |||||...| ||
tvndfWelvyenktstivmltelveggk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1718-1842 1.3e-24 81.6 In-house 2-127 (315) alignment 
Range on Protein: 1718-1842
Range on HMM: 2-127/315.0
PIHVSVFHSHVLEmhSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVAL---TTKRDSDYINACFVDGYARKNCYIAAQGPLRRT
|| |. | . | .        | .||. .      . ...  . | .|||. ||.|.| .|| |     . ||||||| .. ..   ..|||.||||. .
pipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

VDDFWHMIWEHKLNHIVMLTGIIEAGKV
|||||.|....|   |||.|   |  |.
vddfwrmvlqekvttivmvtkkqegdki
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1718-1845 2.4e-24 80.5 In-house 3-131 (392) alignment 
Range on Protein: 1718-1845
Range on HMM: 3-131/392.0
PIHVSVFHSHVLEMhsNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVAL---TTKRDSDYINACFVDGYARKNCYIAAQGPLRRT
|| |. | . | .        | .||. .      | |..  | |..|||. ||.|||..|| |       ||||.|| .....  ...|||.|||   .
pipvaqfpafvekn..rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

VDDFWHMIWEHKLNHIVMLTGIIEAGKVYDA
.||||.|.....   |.|.| . |. |  ||
lddfwrmvfqenvttiamvtklkegdkgdda
subfamily_PTPRG_pd Subfamily PTPRG 1719-1841 1.3e-37 124.3 In-house 1-130 (563) alignment 
Range on Protein: 1719-1841
Range on HMM: 1-130/563.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSISM---TSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTK----RDSDYINACFVDGYARKNCYIAAQGPL
..|. |..|| ..|...|. |..||... .   ..  .... . . |  ||| ||| .|| .|| |.      .. ||||| ..||| ... .||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

RRTVDDFWHMIWEHKLNHIVMLTGIIEAGK
. |.||||.||||.. . |||.| . | |.
kdtfddFWrmiWeqnvaiivmitnlvergr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1719-1842 2.5e-37 123.7 In-house 2-129 (318) alignment 
Range on Protein: 1719-1842
Range on HMM: 2-129/318.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTA-GSSEANIPKNRFLNIFPYDATRVALTTK---RDSDYINACFVDGYARKNCYIAAQGPLRRT
|.|. ..||| ..... . ....|.. .| ..  . .    ...|  |||. || .|| |||.|...    .|||||| ..||| ||. |||||.|| .|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VDDFWHMIWEHKLNHIVMLTGIIEAGKV
..||| |.|| .   ||||| . |.||.
ieDfWrmvWeqnsavivmltqeeergka
0043336 (Phosphotyrosine protein) phosphatases II 1719-1874 3.4e-35 117.3 In-house 2-198 (278) alignment 
Range on Protein: 1719-1874
Range on HMM: 2-198/278.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTV
|.|. .. ..||.. |. . . .||...      .|. . ...|..|||. .|.||| .|| |.      ||||||| .|||| ... .||.||||  ||
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

DDFWHMIWEHKLNHIVMLTGIIEAGKVY--------------------------------------DAWEEVGRKVSLLCEWLGHDLPHTLWPILEL
.|||.|.||.. ..|||||.  | |.|                                          |.    .     |  |..|..| ..|..
edFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1719-1842 1.4e-29 97.9 In-house 2-131 (290) alignment 
Range on Protein: 1719-1842
Range on HMM: 2-131/290.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSISMT-SGAPYTAGSSEANIPKNRFLNIFPYDATRVALT---TKRD--SDYINACFVDGYARKNCYIAAQGPLR
| |. |  .| . |.. .. | |.||..  . |    | | .. | ..||| || .||  |. |     ..|   .|||||...||  |. |||.|||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

RTVDDFWHMIWEHKLNHIVMLTGIIEAGKV
.|. |||..||..|   ||||| ||| |||
ntlvdFWkliwqekvtiivmltniieegkv
subfamily_Ptp69D_pd Subfamily Ptp69D 1719-1841 2.5e-29 97.4 In-house 4-130 (307) alignment 
Range on Protein: 1719-1841
Range on HMM: 4-130/307.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSISM-TSGAPYTAGSSEANIPKNRFLNIFPYDATRVALT---TKRDSDYINACFVDGYARKNCYIAAQGPLRRT
|..   .. .   . ..|. . .|....   ..    ...  . |  |||. .| ..| ||| |.    | ||||||| |. ||  |. .||||.|.  |
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

VDDFWHMIWEHKLNHIVMLTGIIEAGK
..||| ||.| ... ||||. . |  .
igDfWRmiaeqevtlivmlsnlteknr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1719-1848 2e-28 94.2 In-house 2-134 (287) alignment 
Range on Protein: 1719-1848
Range on HMM: 2-134/287.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSISM--TSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTtKRDSDYINACFVDGYARKNCYIAAQGPLRRTVD
| |. |   | . | .....| | |. .     .    | . .. | .|||. .| ..|  || |  ... |||||.|.|||  |. .|.|..|. .|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntar

DFWHMIWEHKLNHIVMLTGIIEAG--KVYDAWEE
.||..|.... . ||||.   |    . |. | |
nfWkliddrnvtaivmlcqekendeevcyqyWpe
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1722-1841 9.8e-23 75.8 In-house 8-129 (325) alignment 
Range on Protein: 1722-1841
Range on HMM: 8-129/325.0
SVFHSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD---SDYINACFVDGYARKNCYIAAQGPLRRTVDDF
  .  || . ... .. | .||. .    |  ...    .|. |||| |. ..| .|| | ||.|   |||||| ..  . .|. ..||| ||  |..|.
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WHMIWEHKlNHIVMLTGIIEAGK
| .. . .   .|... ... ||
WrlvldWr.csvvvvlneldlgk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1723-1845 2.1e-24 80.8 In-house 6-134 (439) alignment 
Range on Protein: 1723-1845
Range on HMM: 6-134/439.0
VFHSHVLEMHSNSDQEFDNEFKSISMTSGA---PYTAGSSEANIPKNRFLNIFPYDATRVAL---TTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVD
 |. || ... | .. |...|..|. ||       .  . | . .|||. .. ..| |||.|        | |||| ...||  .. |||.||| . |.|
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWHMIWEHKLNHIVMLTGIIEAGKVYDA
||| ...|.|  .||||| ..|. | . .
dfwrlviekktvtivmltnlvesykywps
0040438 (Phosphotyrosine protein) phosphatases II 1725-1873 6.4e-37 122.9 In-house 6-196 (317) alignment 
Range on Protein: 1725-1873
Range on HMM: 6-196/317.0
HSHVLEMHSNSDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD---SDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHM
. ..| .. .. . . .||. .   .  .|. .. ..|..|||. .|.|||..|| |.       |||||| .|||. .|. .||.||||  ||.|||.|
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

IWEHKLNHIVMLTGIIEAGK---------------------VYDAWEEVGRKVSLLC------------------EWLGHDLPHTLWPILE
.||.....|||||   | |.                     ...  |. | ..  |.                   |  |..| .. ..|.
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld
subfamily_PTPRK_pd Subfamily PTPRK 1725-1848 2.8e-26 87.1 In-house 10-134 (314) alignment 
Range on Protein: 1725-1848
Range on HMM: 10-134/314.0
HSHVLEMHSNSDQEFDNEFKSISMTsgapYTAGSSEANIPKNRFLNIFPYDATRVALTTKR-D--SDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHM
  ..  .. .    | .|..|.       . |   . |  |||. .| .|| .|| |.|   |  |||||| ..|.| | . .|..||||. || ||| .
lqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

IWEHKLNHIVMLTGIIEAG--KVYDAWEE
.....   ||||| ..| |  | .  | |
vydencasivmltelvevgrvkClkyWPe
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1726-1842 2.2e-32 107.3 In-house 4-124 (281) alignment 
Range on Protein: 1726-1842
Range on HMM: 4-124/281.0
SHVLEMHSNSDQEFDNEFKSISM-TSGAPYTAGSSEANIPKNRFLNIFPYDATRVALT---TKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHM
 |. ....|... | .|.....    . . ||  ...|. |||. ||. |||||| .|   .. ..||||| ||.||  .. |||.|||.  ....||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEHKLNHIVMLTGIIEAGKV
.||.| . |||.|  |||||.
vweqkvsaivmvtreieagkl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1727-1841 1.1e-25 85.0 In-house 8-124 (301) alignment 
Range on Protein: 1727-1841
Range on HMM: 8-124/301.0
HVLEMHSNSdqeFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD-----SDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHM
||  .|||.   |....|... ..  . | | ||.| . ||| || .||  |. |..|..      .|||| ..||| .|. .||||||...|. |||..
hvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

IWEHKLNHIVMLTGIIEAGK
||..|  .|||.|.  |  |
iwqekpvsivmvtnlkegtk
subfamily_PTPN14_pd Subfamily PTPN14 1728-1842 3.3e-24 80.4 In-house 15-133 (300) alignment 
Range on Protein: 1728-1842
Range on HMM: 15-133/300.0
VLEMHSNSDQEFdNEFKSIS-MTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD--SDYINACFVDGY--ARKNCYIAAQGPLRRTVDDFWHMI
.||.. .. . |  |.  |. .   | ..... . | .|||| .. ||. .|| |.. ..  ..||||  .     ...  ||.|||||. || |||.|.
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmv

WEHKLNHIVMLTGIIEAGKV
||.... ||||| ..| || 
Weqgvqlivmlteeeedgke
subfamily_PTPRN_pd Subfamily PTPRN 1729-1853 9.2e-22 72.1 In-house 21-153 (297) alignment 
Range on Protein: 1729-1853
Range on HMM: 21-153/297.0
LEMHSNSDQEFDNEFKSISMTSGAPYTA--GSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFV-DGYARKNCYIAAQGPLRRTVDDFWHMI
|| | .  . ...|....      | |.  ...| |. |||  ...||| .|| |..   . .|||||| .. |   |. .|||.||||  || ||| |.
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmv

WEHKLNHIVMLTGIIEAG--KVYDAWEEVGRKV
||.    ||.|| . | |  ...  | . | .|
weqGvvvivnltrleeegvkqckrywpdeGsev
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1729-1833 7.5e-08 26.3 In-house 6-116 (347) alignment 
Range on Protein: 1729-1833
Range on HMM: 6-116/347.0
LEMHSNSD-QEFDNEFksiSMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKR--------DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFW
|...  |    ||...   .  | . .|.   | .. |||  .    ||||| |. ..           ||||  .     .. || .| ||  || |||
ldikeaslstyfdenl...anyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfw

HMIWEHKLNHIVML
.|.   |.  .| .
kmvsvtkvtqvvti
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1730-1842 1.9e-31 104.5 In-house 20-139 (298) alignment 
Range on Protein: 1730-1842
Range on HMM: 20-139/298.0
EMHSNSDQEFDNEFKSISMTSG----APYTAGSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMI
 .....   ...||. .. .|     . ........|  |||. .| ..| .|| |..   . .|||||| |...| ..| .||.|.|| .|| |||.|.
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WEHKLNHIVMLTGIIEAGKV
.|.. . ||||| . | .|.
teedigtiVmltnleeldkt
subfamily_PTPN6_pd Subfamily PTPN6 1732-1841 2.5e-25 84.1 In-house 21-137 (306) alignment 
Range on Protein: 1732-1841
Range on HMM: 21-137/306.0
HSNSDQEFDNEFKSISMT---SGAPYTAGSSEANIPKNRFLNIFPYDATRVAL--TTKRDSDYINACFVDGYAR--KNCYIAAQGPLRRTVDDFWHMIWE
.| . . | .||.... .   .    . |.   |  |||. ||.|.| ||| |      .|||||| .... ..  ...|||.|| |. || |||.|.|.
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

HKLNHIVMLTGIIEAGK
 . . |||.|  .| ||
ensrvivmttkevErgk
subfamily_ptpA1_pd Subfamily ptpA1 1732-1839 1.1e-18 62.2 In-house 16-126 (418) alignment 
Range on Protein: 1732-1839
Range on HMM: 16-126/418.0
HSNSDQEFDNEFKSISMTSGAPYT-AGSSEANIPKNRFLNIFPYDATRVALT---TKRDSDYINACFVDGYARKNcYIAAQGPLRRTVDDFWHMIWEHKL
| .  ..  .||. .  . |   |  |  . |  |||. ||.| . ||| |     |  |||||| ..||   |. .|..||||  |. |||.|.|| . 
hikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrc

NHIVMLTGIIEA
  ||||.   | 
riivmlsresen
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1733-1849 8.2e-26 85.4 In-house 10-129 (287) alignment 
Range on Protein: 1733-1849
Range on HMM: 10-129/287.0
SNSDQEFDNeFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVAL--TTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHI
 . |.|.|. .|  | .| | . |    |.. |||. ...|.| ||| |  ...  |||||| .| .| ... .||||||.  || ||| ...|..   .
ddvdkevda.lkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv

VMLTGIIEAGK--VYDAWEEV
...|  .| ..  .|  | | 
itmtreveearlkcykywPer
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1733-1840 1.3e-23 78.3 In-house 5-113 (283) alignment 
Range on Protein: 1733-1840
Range on HMM: 5-113/283.0
SNSDQEFDNEFKSISMTSgAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRDsDYINACFVD---GYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNH
.|. . | . .| .|. .  . .  |.. | .|||. .| |.|  || | ..   |||||.|.     | ... ||.||.||.||| |||.|....|   
vnnnklfrevlkrlsvpd.ldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMLTGIIEAG
||||| . |  
ivmltklqedl
subfamily_PTPN12_pd Subfamily PTPN12 1734-1842 2.9e-28 93.6 In-house 5-123 (290) alignment 
Range on Protein: 1734-1842
Range on HMM: 5-123/290.0
NSDQEFDNEFKSISMTSG-------APYTAGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIW
....|| .||... ..|         . .||..| |. |||. .|.||| .|| |....   .|||||| |. | . |  |||||||| .|.||||.|||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

EHKLNHIVMLTGIIEAGKV
|.... .||.  ..| || 
eknveivvmaCrevelgkk
subfamily_PTPN23_pd Subfamily PTPN23 1734-1842 1.9e-24 81.0 In-house 12-123 (288) alignment 
Range on Protein: 1734-1842
Range on HMM: 12-123/288.0
NSDQEFDNEFKSISMTSGAPYT---AGSSEANIPKNRFLNIFPYDATRVALTTKRDsDYINACFVDGYA-RKNCYIAAQGPLRRTVDDFWHMIWEHKLNH
.   ..|..|| . ..  .         .. .  |||. .|.||| .|| |  ..| |||||.|| . .    ..||.|.||. |. ||| |..| | . 
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD.DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLTGIIEAGKV
||||.   | || 
iVmllskeelgkp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1734-1836 3.4e-21 70.5 In-house 3-106 (267) alignment 
Range on Protein: 1734-1836
Range on HMM: 3-106/267.0
NSDQEFDNEFKSISMTSGAPYT--AGSSEANIPKNRFLNIFPYDATRVALTTKRDsDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIV
....|...||. |   |    |     .| |  .||. .  ||| ||| | || . .|||| .|.|| .|| .|. |.||. |. ||. .| ..|.  ||
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkee.eyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTGI
.|| .
lltkv
0047943 (Phosphotyrosine protein) phosphatases II 1735-1874 4.2e-35 116.9 In-house 10-191 (273) alignment 
Range on Protein: 1735-1874
Range on HMM: 10-191/273.0
SDQEFDNEFKSI-SMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALtTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVML
. . .  ||. . |..   .|.... ..|. |||. .|.||| .|| | .  .|||||| .|||| .|. .||.||||  ||.|||.|.||.. ..||||
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

TGIIEAGK--VYDAWEEVGRK----------------------------------------VSLLCEWLGHDLPHTLWPILEL
| ..| |.   .  | . | .                                        . .  .|  |. |..| ..||.
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef
subfamily_CG7180_pd Subfamily CG7180 1735-1843 2.5e-23 77.2 In-house 15-126 (296) alignment 
Range on Protein: 1735-1843
Range on HMM: 15-126/296.0
SDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIV
   |.. |.| ..  .     .|  . |. |||  .. ||| .|| |..   . .|||||| .||.. .|. ||  ..| ..|||.|| ...... . .|
frveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MLTGIIEAGKVY
.||   .  | |
vLtktfdfakmy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1735-1842 1.4e-15 52.1 In-house 14-122 (307) alignment 
Range on Protein: 1735-1842
Range on HMM: 14-122/307.0
SDQEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTK-RDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVML
  |.. .||. ..  .    |. . .||  |||. ..   | .|. ....   |||| | ..    . . .|.|||||  |. .|| |. ..|.. ..||
gvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TGIIEAGKV
  .|| .|.
ckvielaki
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1737-1834 1.8e-27 91.5 In-house 34-136 (319) alignment 
Range on Protein: 1737-1834
Range on HMM: 34-136/319.0
QEFDNEFKSISMT--SGAPYTAGSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIV
...  ||. ..    ..|  |    . |  |||. ||...| ..| |     .  |||||| ||.|| ||. ||||||||  |..||| ||||..   ||
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLT
.||
llt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1737-1842 1.2e-24 81.3 In-house 18-126 (515) alignment 
Range on Protein: 1737-1842
Range on HMM: 18-126/515.0
QEFDNEFKSISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVAL---TTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVML
  | .||. .      | |    | | .|||. ||.||| .|| |     . .|||.|| .. ..   ..|||.|||.. .|||||.......   |.|.
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TGIIEAGKV
|   |  |.
tklkegdki
DSPc_SM00195 1739-1848 4e-31 103.7 In-house 2-117 (263) alignment 
Range on Protein: 1739-1848
Range on HMM: 2-117/263.0
FDNEFKSISMT-SGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLT
...||... .  |  . | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.||||  ||.|||.|.||.| . |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GIIEAG--KVYDAWEE
   | |  |... |.|
eeeengkekcdrywpe
PTPc_SM00194 1739-1848 4e-31 103.7 In-house 2-117 (263) alignment 
Range on Protein: 1739-1848
Range on HMM: 2-117/263.0
FDNEFKSISMT-SGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLT
...||... .  |  . | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.||||  ||.|||.|.||.| . |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GIIEAG--KVYDAWEE
   | |  |... |.|
eeeengkekcdrywpe
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1739-1840 5.6e-24 79.7 In-house 7-111 (274) alignment 
Range on Protein: 1739-1840
Range on HMM: 7-111/274.0
FDNEFKSISMTSgAPYtAGSSEANIPKNRFLNIFPYDATRVALTT----KRDSDYINACFVDGYAR-KNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVML
...|| .. .    .    .   .  |||. .|.| . .|| |..    . ||.|||| .. || . ...|.|.||||  ||.|||.||.... . ||||
lekeflelPlnf.dqe.eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TGIIEAG
| . || 
tklkean
0046845 (Phosphotyrosine protein) phosphatases II 1740-1873 2.4e-35 117.7 In-house 3-189 (284) alignment 
Range on Protein: 1740-1873
Range on HMM: 3-189/284.0
DNEFKSISMTSGA---PYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD----SDYINACFVDGY-----ARKNCYIAAQGPLRRTVDDFWHMIWEHKL
. ||. . .       .....  ..|. |||. .|.||| .|| |..  .    |||||| .||||      .|. .||.||||  ||.|||.|.||.. 
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

NHIVMLTGIIEAGKV--YDAW-------------------------------------EEVGRKVSLL--CEWLGHDLPHTLWPILE
..|||||...| |..  .  |                                     ..  |.|  .   .|  |. |... ..||
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlle
subfamily_PTPN13_pd Subfamily PTPN13 1740-1842 3.2e-23 77.4 In-house 14-117 (273) alignment 
Range on Protein: 1740-1842
Range on HMM: 14-117/273.0
DNEFKSIS-MTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRDsdYINACFVDGYARKNC--YIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGI
..||| .  . .    . | ...|  |||. |..|||.||| |  .    |||| ..     |.   |||.||||  ||.||| |.|| | . |.|.|  
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

IEAGKV
 | |||
kekgkv
subfamily_PTPN1_pd Subfamily PTPN1 1740-1842 1.7e-22 74.5 In-house 9-111 (290) alignment 
Range on Protein: 1740-1842
Range on HMM: 9-111/290.0
DNEFKSISMTSG-APYTAGSSEANIPKNRFLNIFPYDATRVALTtKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIE
.. .. |.  .   | ..   ..| ..||. .. ||| .|. |  . | ||||| .|.    |  || .|||| .||| ||.|.||.|   .|||  ..|
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle.radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

AGKV
 ...
keqi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1740-1842 2.8e-11 37.5 In-house 14-116 (332) alignment 
Range on Protein: 1740-1842
Range on HMM: 14-116/332.0
DNEFKSISMTSgaPYTAGSSEANIPKNRFLNIFPYDATRVALTTKR-DSDYINACFVDGYARKNCYIAAQGPLRR-TVDDFWHMIWEHKLNHIVMLTGII
 |.... .||   | |      |.  ||   .. .| .|| |. .    |. || .||||..|..|| || |.   |   ||.|. |.| . |...  | 
lnqmhtsamty..pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid

EAGKV
|  | 
ekqkr
0045098 (Phosphotyrosine protein) phosphatases II 1745-1874 6.6e-31 103.1 In-house 16-181 (278) alignment 
Range on Protein: 1745-1874
Range on HMM: 16-181/278.0
SISMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVAlttkrdsDYINACFVDGYarKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVY-
 ... .   .| .  . |..|||. .|.||| .||        ||||| ..|||  .. .||.||||  ||.|||.|.||.. ..|||||. .| |..  
llllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

------------------------------------------DAWEEVGRKVSLLCEWLGHDLPHTL--WPILEL
                                            .|. | ..  .  |  |. |..   ...|||
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflel
0049772 (Phosphotyrosine protein) phosphatases II 1745-1847 3.8e-18 61.7 In-house 29-156 (314) alignment 
Range on Protein: 1745-1847
Range on HMM: 29-156/314.0
SISMTSGAPYTAGSSEANIPKNRFLNIFPYDaTRVALtT---KRDSDYINACFVDGYarkNCYIAAQGPLRRTVDDF----------WHMI--WEHKLNH
|.|...   ..... ..|. |||.|.|.|.| .|| |      ..|||||| .|||.   . .||.||||  ||.||          |.|.  .....  
slsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IVM---------------------LTGIIEAGkvydawE
|||                     |... . |       
ivmsrdevladelsrLdaAlgKtpllildgng......n
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1747-1843 4.9e-16 53.2 In-house 40-137 (305) alignment 
Range on Protein: 1747-1843
Range on HMM: 40-137/305.0
SMTSGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRDSDYINACFVDGY-ARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVY
 ||  |  .  |.. .| |||. ..   | . | |     |||| | .|      .. .|.||||| .|.|.|| |. ..|...||||   .| ||. 
dmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk
0036941 (Phosphotyrosine protein) phosphatases II 1749-1847 2.4e-35 117.7 In-house 26-125 (297) alignment 
Range on Protein: 1749-1847
Range on HMM: 26-125/297.0
TSGAPYTAGSSEANIPKNRFLNIFPYDATRVALtTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK--VYDAW
    .........|..|||. .|.||| ||| | .. .||||||..|||| .|. .||.||||  ||.|||.|.||.. ..|||||  .| |.   .  |
lllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqyw

E
 
p
subfamily_egg_pd Subfamily egg 1750-1846 3.6e-15 50.4 In-house 28-127 (307) alignment 
Range on Protein: 1750-1846
Range on HMM: 28-127/307.0
SGAPYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD---SDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVYDAW
   ..|   |. |  | |   .   | .||.|  .|     |.| |  |.|    | .| || ||. |||||| |... . ..|||||   |. .    |
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyyw
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1750-1840 2e-14 48.2 In-house 25-113 (285) alignment 
Range on Protein: 1750-1840
Range on HMM: 25-113/285.0
SGAPYTAgsSEANIPKNRFLNIFPYDATRVALTtKRDSDYINACFVDGYAR-KNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG
  . |||   |||   ||. ..   . ||| |  ..| ||| | ..    . .. ||..||||  |. ||||||.. |. ...||  ..| |
pnctyta..yeanpdlnryadvrcieetrvvlk.nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1751-1847 2.6e-18 60.9 In-house 22-123 (297) alignment 
Range on Protein: 1751-1847
Range on HMM: 22-123/297.0
GAPYTAGSSEANIPKNRFLNIFPYDATRVALT-TKRDSDYINACFVDGY--ARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK--VYDA
|  ...   .. . |||. .|. .| ||| |  .  ..||||| .|       .  || |||||..||||||....|. .. |||.. . | |.   .  
gesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WE
| 
wp
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1751-1842 1.7e-15 51.8 In-house 32-122 (288) alignment 
Range on Protein: 1751-1842
Range on HMM: 32-122/288.0
GAPYTAGSSEANIPKNRFLNIFPYDATRVALTtkRDSDYINA-CFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV
..  .. |  ||  ..|. |..  |.||| |.   |.|.  |   |     |.  | || ||. |.. .|.|. |  ...||||. ..| || 
asidiidsfianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke
0040439 (Phosphotyrosine protein) phosphatases II 1753-1874 2.6e-30 101.2 In-house 2-165 (249) alignment 
Range on Protein: 1753-1874
Range on HMM: 2-165/249.0
PYTAGSSEANIPKNRFLNIFPYDATRVALTTKRD---SDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVY------
.|. .. ..|..|||. .|.||| .|| |.  ..   |||||| ..||| .|. .||.||||  ||.|||.|.||.. ..|||||   | |..       
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

---------------------------------DAWEEVGRKVSLLCEWLGHDLPHTLWPILEL
                                    |..  ..     |  |..| .. ..|..
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf
subfamily_PTPN9_pd Subfamily PTPN9 1754-1842 7.2e-29 95.7 In-house 34-125 (297) alignment 
Range on Protein: 1754-1842
Range on HMM: 34-125/297.0
YTAGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV
..|  . ||. |||. ..  || ||| |...     |||||| ||||| .|...||.||||..||.||| |.||..   ||| | ..| |..
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1754-1834 6.8e-27 89.7 In-house 17-100 (284) alignment 
Range on Protein: 1754-1834
Range on HMM: 17-100/284.0
YTAGSSEANIPKNRFLNIFPYDATRVALTT---KRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLT
 |    . |  |||. .|...| ..| |     .  |||||| |. || ||. |||.||||  |..||| ||||..   ||.||
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1754-1840 3.2e-14 47.3 In-house 29-119 (281) alignment 
Range on Protein: 1754-1840
Range on HMM: 29-119/281.0
YTAGSSEANIPKNRFLNIFPYDATRVALTT----KRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG
 |.     |  |||.|||   | .|| |      |  .||| | ..     |  || .||| . |  |||.|||. .   ||||  ..|. 
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn
0037934 (Phosphotyrosine protein) phosphatases II 1755-1874 2.2e-26 88.3 In-house 3-158 (243) alignment 
Range on Protein: 1755-1874
Range on HMM: 3-158/243.0
TAGSSEANIPKNRFLNIFPYDATRVALttkRDSDYINACFVDGYarkNCYIAAQGPLRRTVDD----FWHMIWEHKLNHIVMLTGIIEAGKV--------
. .....|..|||. .|.||| .|| |    .|||||| .....   . .|| ||||  ||.|    ||.|.||.. ..|||||  .| |..        
siallpenlsknrysdilpydhsrvkl...egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpg

-----------------------------YD-AWEEVGRKVSLLCEWLGHDLPHTLWPILEL
                             .|   ..      .   | .|. | .  ..|..
evtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1755-1833 2.2e-10 34.7 In-house 40-114 (303) alignment 
Range on Protein: 1755-1833
Range on HMM: 40-114/303.0
TAGSSEANIPKNRFLNIFPYDATRVALTtkrDSDYINACFVDGYARKNCyIAAQGPLRRTVDDFWHMIWEHKLNHIVML
.      |. |||| ..   | ..| |.   || || | ...  ..|.. | .| ||  |  ||| || | |.. ...|
sknqfvknmdknrfvdvicldhskvkls...dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlll
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1755-1797 2.8e-06 21.1 In-house 32-76 (244) alignment 
Range on Protein: 1755-1797
Range on HMM: 32-76/244.0
TAGSSEANIPKNRFLNIFPYDATRVALTT--KRDSDYINACFVDG
|     ||  |||..||.|.| ||| |..  |  |||||| ...|
tnavlsanatknryinilpfdetrvilssskkegsdyinanyiqg
0042113 (Phosphotyrosine protein) phosphatases II 1756-1873 7.8e-30 99.5 In-house 3-162 (245) alignment 
Range on Protein: 1756-1873
Range on HMM: 3-162/245.0
AGSSEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV----------
 .. ..|..|||. .|.||| ||| |.      |||||||..|||| ... .||.||||. ||.|||.|.||.....|||||   | |.|          
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

------------------------------YDAWeEVGRKVSLLCEWLGHDLPHTLWPILE
                              .| . .    . .   | .|. |..|  .|.
sltygdftvtllseehlddytvrtlevtnlgdde.srevihyhylpwpdhgvpdllellld
subfamily_PTPN3_pd Subfamily PTPN3 1757-1842 7.6e-27 88.9 In-house 36-124 (280) alignment 
Range on Protein: 1757-1842
Range on HMM: 36-124/280.0
GSSEANIPKNRFLNIFPYDATRVALTTKRDsDYINACFVD----GYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV
    .|..|||. .| ||||||| |.  .  ||||| .|.    . .  | |||.||||..|. |||.|.||.| . ||||| ..| |.|
arkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1759-1845 3.8e-27 90.1 In-house 6-95 (250) alignment 
Range on Protein: 1759-1845
Range on HMM: 6-95/250.0
SEANIPKNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVYDA
  .|  |||. .| ..| .|| | ...   .|||||| |..||  .. .||.|||| .|. ||| |..|.| . ||||| . | .|.|  
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1759-1847 8.6e-15 49.1 In-house 49-141 (310) alignment 
Range on Protein: 1759-1847
Range on HMM: 49-141/310.0
SEANIPKNRFLNIFPYDATRVALTT--KRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVY--DAWE
 . .. |||. ..   |..|| |.    |  ||| | .|     .. .| .||||. |. ||| ||.. . . |..|  . | |.      | 
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1760-1846 1.7e-16 55.1 In-house 6-98 (239) alignment 
Range on Protein: 1760-1846
Range on HMM: 6-98/239.0
EANIPKNRFLNIFPYDATRVALT---TKRDSDYINACFVDGYA-RKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK--VYDAW
  |  |||. ||  || .|| |        |||||| ..  |    ..|||.|| .  .  |||.|.|. .   ||||||.||  |  ... |
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqyw
subfamily_eak_pd Subfamily eak 1760-1839 7e-06 19.6 In-house 50-130 (332) alignment 
Range on Protein: 1760-1839
Range on HMM: 50-130/332.0
EANIPKNrFLNIFPYDATRVALTTK--RDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEA
  .. .|  ..| |||   | ||.       ||||  ..     . || .  .    |  || |. | |   ||.|   .| 
leavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1761-1846 2e-16 54.9 In-house 6-97 (239) alignment 
Range on Protein: 1761-1846
Range on HMM: 6-97/239.0
ANIPKNRFLNIFPYDATRVALT---TKRDSDYINACFVDGYA-RKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK--VYDAW
 |  |||. ||  || .|| |        |||||| ..  |    ..|||.|| .  .  |||.|.|. .   ||||||.||  |  ... |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqyw
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1761-1842 1e-15 52.2 In-house 55-134 (290) alignment 
Range on Protein: 1761-1842
Range on HMM: 55-134/290.0
ANIPKNRFLNIFPYDATRVALTTKRDSDYINACFVDGYarKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV
... |||. ..   | ||| |    | ||. | .|.|   |  .| .||.|. || |.| |. ..|   ||||  .|| || 
tefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka
Y_phosphatase Protein-tyrosine phosphatase 1762-1841 3e-28 94.2 Pfam-A 1-81 (235) alignment 
Range on Protein: 1762-1841
Range on HMM: 1-81/235.0
NIPKNRFLNIFPYDATRVAL-TTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.||||  |..|||.|.|..| . |||||   | |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr
Y_phosphatase Protein-tyrosine phosphatase 1762-1841 3e-28 94.2 In-house 1-81 (235) alignment 
Range on Protein: 1762-1841
Range on HMM: 1-81/235.0
NIPKNRFLNIFPYDATRVAL-TTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.||||  |..|||.|.|..| . |||||   | |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr
0041856 (Phosphotyrosine protein) phosphatases II 1762-1873 8.2e-21 69.8 In-house 1-100 (182) alignment 
Range on Protein: 1762-1873
Range on HMM: 1-100/182.0
NIPKNRFLNIFPYDATRvalttkrDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTgiieaG--KVYDAWEEVGRKVSLLcEW
|..|||. .|.||| .|       |.||||| ...|. . . .||.|||| .|| ||..|..|.. ..||.||     .    .. .|  | ..  |  |
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywpellerlgiqylyl.pw

LGHDLPHtLWPILE
 .|. |  |  .|.
pDhgvpd.ldelld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1763-1841 7.1e-21 69.5 In-house 4-84 (237) alignment 
Range on Protein: 1763-1841
Range on HMM: 4-84/237.0
IPKNRFLNIFPYDATRVALTT-KRDSDYINACFVDGYAR-KNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK
  |||. ||  || .|| |     .||||||....|.    . ||||||||  . |||| |.|. |   ||||||.||  .
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegne
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1763-1850 2.7e-16 54.3 In-house 48-154 (350) alignment 
Range on Protein: 1763-1850
Range on HMM: 48-154/350.0
IPKNRFLNIFPYDATRVALT-----------TKRDSDYINACFVDGY----A-RKN-CYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG--KVY
  |||. ||.||. .|| |            . . .||||| ..           .  |||.|.||..|||||...| . | . |..||  .| .  |.|
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

DAWEEVG
  |.| .
rYWqegs
subfamily_CG42327_pd Subfamily CG42327 1763-1842 1.1e-13 45.5 In-house 29-113 (319) alignment 
Range on Protein: 1763-1842
Range on HMM: 29-113/319.0
IPKNRFLNIFPYDATRVALTTKRD---SDYINACFVDGYARK-NCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG-KV
 .|.|..|. |   ||| |  . |   . |..| .| ||    | ||||| .|  .  ||| ..|| .   || || . | | ||
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1763-1840 7e-13 43.0 In-house 49-126 (305) alignment 
Range on Protein: 1763-1840
Range on HMM: 49-126/305.0
IPKNRFLNIFPYDATRVALTTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG
  |||. ..   |  || | .    .|| | .|   .  . .| .| || .|  |||.| ...|.. | ||  ..| |
agknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1763-1848 9.2e-07 22.5 In-house 49-155 (349) alignment 
Range on Protein: 1763-1848
Range on HMM: 49-155/349.0
IPKNRFLNIFPYDATRVALTTK-----------------RDSDYINACFVD--GYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEA--GK
  |||. .|.||. .|| |                    .  ||||| ..    .. .. ||| | ||  |||||...|   ... .. |.   |   .|
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

VYDAWEE
..  |.|
cdiywqe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1764-1840 5.2e-11 36.6 In-house 98-175 (244) alignment 
Range on Protein: 1764-1840
Range on HMM: 98-175/244.0
PKNRFLNIFPYDATRVALTTK-RDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG
 |||    .|.|  || |.       |||| ||    |   || .| ||  |  |||.|. | ..| .|.|  . |  
wknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1765-1841 4.4e-22 73.4 In-house 23-103 (270) alignment 
Range on Protein: 1765-1841
Range on HMM: 23-103/270.0
KNRFLNIFPYDATRVALTTKR---DSDYINACFVDGYARK-NCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK
 ||. .| |  |||| | . .    . |||| .| |.  . . ||||.|||  |. .|| ||||.| . |||.||. | |.
lnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1765-1839 3.2e-10 34.2 In-house 53-127 (301) alignment 
Range on Protein: 1765-1839
Range on HMM: 53-127/301.0
KNRFLNIFPYDATRVALTTKRDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEA
|.|. ..     | | . ..     | | ...   . . .||.||||. | .||| |.  .....||||.  .| 
khryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvek
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1765-1841 3.6e-08 27.5 In-house 46-121 (312) alignment 
Range on Protein: 1765-1841
Range on HMM: 46-121/312.0
KNRFLNIFPYDATRVALTTKrDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGK
 ||. ||  .|  | .|.   .  || | ||   .. . ....||||  |.  ||..        |..|.|..| | 
lnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgs
0044763 (Phosphotyrosine protein) phosphatases II 1773-1873 5.6e-09 31.4 In-house 1-97 (178) alignment 
Range on Protein: 1773-1873
Range on HMM: 1-97/178.0
PYDATRVALTTKRD---SDYINACFVDGYarknCYIAAQGPlrrtvDDFWHMIWEHKLNHIVMLTGIIEAGK---VYDAWEEVGRKVSLLcEWLGHDLPH
|.| ||| |.. ..   ||||||......     |.....|      |.. ...|....|||.||. .| |.      ..|| | ..  .  . .|. | 
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeagiqylhi.pipDhgvpd

TLWPILE
 |. .||
llehfle
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1773-1840 9.2e-08 26.5 In-house 4-66 (130) alignment 
Range on Protein: 1773-1840
Range on HMM: 4-66/130.0
PYDATRVAlttkrDSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAG
... .|.      . .|||| ||    | . |. .| ||  |  |||.|. |  .| .|.|  . |  
efevsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed
0046846 (Phosphotyrosine protein) phosphatases II 1783-1849 1.3e-12 43.3 In-house 8-72 (176) alignment 
Range on Protein: 1783-1849
Range on HMM: 8-72/176.0
TKRDSDYINACFVDGYarknCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKV--YDAWEEV
   |.||||| ...|.    ..|| ||||.||. ||..|..|.. ...|.||  .| |..  .. |.|.
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpel
0043147 (Phosphotyrosine protein) phosphatases II 1786-1870 7.1e-15 50.6 In-house 4-83 (172) alignment 
Range on Protein: 1786-1870
Range on HMM: 4-83/172.0
DSDYINACFVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIieagkVYDAWEEVGR-KVSLLCEWLGHDLPhTLWP
.|||||| ..|.|   . .|| |||||.|..|||.|..|.. .|||.||.      .||.. ..      | . |  |. | .|  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.....lydpellerlgiqylylpwpDhgvp.llel
0051429 (Phosphotyrosine protein) phosphatases II 1787-1844 2.2e-13 46.0 In-house 4-63 (272) alignment 
Range on Protein: 1787-1844
Range on HMM: 4-63/272.0
SDYINACFVDGYAR---KNCYIAAQGPLRRTVDDFWHMiWEHKLNHIVMLTGIIEAGKVYD
|.|||| .|.|| |   .. .....|||. |..|||.. .|.....||.|..  | |..  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkc
0036282 (Phosphotyrosine protein) phosphatases II 1787-1865 7.5e-13 44.0 In-house 2-83 (174) alignment 
Range on Protein: 1787-1865
Range on HMM: 2-83/174.0
SDYINACFVDGYARKNCYIAAQGPLRrtvddFWHMIWEHKLNHIVMLTGIIEAG--KVYDAWEEVGR------KVSLLCEWLGHDLP
|||||| ..|.. . . .|| ||||.     ||.|..|......|||.  .| |  |... | |            | . | .|  |
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvp
0051082 (Phosphotyrosine protein) phosphatases II 1787-1857 1e-10 36.9 In-house 3-64 (151) alignment 
Range on Protein: 1787-1857
Range on HMM: 3-64/151.0
SDYINACFVDGYarkncYIAAQGPlrrtVDDFWHMIWEHKLNHIVMLTGIIEAGKVYDAWEEVGRKVSLLC
|||||. .|.|.     ... .||     .||. ...|.....||.|..  | |. .. ..| |..|  . 
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeergycpeylpelgievlhip
0049260 (Phosphotyrosine protein) phosphatases II 1794-1863 1.7e-11 39.5 In-house 1-66 (152) alignment 
Range on Protein: 1794-1863
Range on HMM: 1-66/152.0
FVDGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGIIEAGKVYDAWEEvgrkVSLLCEWLGHD
|.||||... .||.|||.. |..|||.|..|.. ..|||||   | ||.. ..        | . |  | 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....qylhlpwpDhg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1796-1836 1e-07 25.7 In-house 230-270 (440) alignment 
Range on Protein: 1796-1836
Range on HMM: 230-270/440.0
DGYARKNCYIAAQGPLRRTVDDFWHMIWEHKLNHIVMLTGI
.||..||..||.| ||  || ||| .. ....  |.||  .
egyskknafiatqmpldstvldfwrlvhdyristiimlnql
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1802-1833 4.4e-07 24.3 In-house 5-36 (199) alignment 
Range on Protein: 1802-1833
Range on HMM: 5-36/199.0
NCYIAAQGPLRRTVDDFWHMIWEHKLNHIVML
  |||.| ||| |. ||| |.||    ||||.
rryiatqhplretmadfwqmvwetgsghivmv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1802-1833 4.6e-07 24.2 In-house 4-35 (198) alignment 
Range on Protein: 1802-1833
Range on HMM: 4-35/198.0
NCYIAAQGPLRRTVDDFWHMIWEHKLNHIVML
  |||.| ||| |. ||| |.||    ||||.
rryiatqhplretladfwqmvwetgsghivmv