Gene PTPRD-37 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP092_AA protein Get Run
AqueP092_AA_6-227 phosphatase_domain Get Run
AqueP092_AA_238-513 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-243 9.5e-136 446.2 In-house 66-283 (283) alignment 
Range on Protein: 1-243
Range on HMM: 66-283/283.0
MVNKDDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNtmmgnlrski
.|.|...|..|||..|.||||||||||.||..||..|||||||||||||||||||||.|||||||.|||||.||||||||||.||.|..|          
pvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..........

vnptgridpnkkeyySSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTI
               |||.||||..|||.|||||||.|..|||||||||.||.|||.||||||||||||.|||..||..|.|.|||||||..|..|||.|
...............ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvki

MREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIVACDLQNTIS
|||||||..||||||.||||.||||||||||||.|.|||.||.
mreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqstia
subfamily_PTPRN_pd Subfamily PTPRN 3-87 5.6e-21 69.5 In-house 93-178 (297) alignment 
Range on Protein: 3-87
Range on HMM: 93-178/297.0
NKDDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKET-TSNSFIIRELTL
 ..| ..  ||||||||  || |||.|||.. .. ||.||.|.|.   .|..|||  ||| |. . | |  |   .. ...| . |
ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4-224 1.6e-51 170.1 In-house 84-277 (288) alignment 
Range on Protein: 4-224
Range on HMM: 84-277/288.0
KDDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS-EDYGPFTVTLQKETTSNSFIIRELTLHyntmmgnlrskivn
.......|||||||||  || |||..|...|.  |||||.| |. . || .|||. .  . || .||||... . ..|. |.| |.              
dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..............

ptgridpnkkeyysSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMR
                .. | ||.||.  | . |     . |... ... .. . . |||.|||| | |||| || . . |.   .|  ||. ..|. .|
..............kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklR

EQRMMMIQTLDQYMLVHEAVLE
.||....||| ||. ..|..|.
kqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4-90 8.1e-20 65.9 In-house 70-160 (297) alignment 
Range on Protein: 4-90
Range on HMM: 70-160/297.0
KDDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSED--YGPFTVTLQKETT--SNSFIIRELTLHYN
 |.|.  ||| .||||..|| |||..|...   .|||..||||| | ||  ||||   |    | . |    .|.   .  |. ||.| | 
pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4-87 4.5e-16 53.9 In-house 85-169 (325) alignment 
Range on Protein: 4-87
Range on HMM: 85-169/325.0
KDDEQSQKYIATQGPLDRTVVDFWRMV--WQekaCAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTL
.|| . . ..|.| ||  |. |.||.|  |.   |..|...   .    .|..||| .   |  .|.. | |.   .   .. | | .
rddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 5-224 6.3e-51 168.1 In-house 68-266 (274) alignment 
Range on Protein: 5-224
Range on HMM: 68-266/274.0
DDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG----SEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGNlrski
 ||.|. |.||||||  || |||||..||..  |||||||.|  . ||..|.| .     || || . .. .| .. | . .|.|.|.| .   .     
ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers.....

vnptgridpnkkeyyssaqstllITHYQFIDWLEYGPQPPINSLVKFNKIISN---QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAV
                       ..|| . || .      .|.|... . ...   ....| .|.||||| | ||||.||..| ....   |...|.  .
.......................vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlki

VTIMREQRMMMIQTLDQYMLVHEAVLE
|. .| .|  |.|| .|| |.|.|. .
vcnlrldrGGmvqtseqyelihralcl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 5-223 1.2e-28 94.9 In-house 99-341 (350) alignment 
Range on Protein: 5-223
Range on HMM: 99-341/350.0
DDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDygpFTVTLQKeTTSNSFIIRELTLHYNTMMGNLRskiVNPT
. . . ||||||.|| .|| ||.... . |   |..||...|  . || .||.  . .|   .|| |.  .  |   |.. .|.   . ..      |  
einpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydd...itvklas.kwenimgindsslysadvkkeas...dndn

GRIDPNKKEYYSS------AQSTLLITHYQFIDWLEY----GPQPPINSLVKFNKIISNQT------EHKKGPIVVHCSTGGGRTGAFIGMSCSIK----
   | . |...|       |   . . . |.  |..      |.  ...|   |..| . .      . .  ||.|||| | |||| .. .   ..    
isddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfei

-DALTESI----------IDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
 . ||.              |  .| ..|.||. |.|.|||.. ..||.|
lenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_hpo-7_pd Subfamily hpo-7 5-178 1e-11 39.2 In-house 33-173 (263) alignment 
Range on Protein: 5-178
Range on HMM: 33-173/263.0
DDEQSQKYIAtqgpLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLqkeTTSN--SfiireltlhyntmmgnlrsKIVN
| .. . |.     | .|.  |.... | |.  .|||.  .|. . |||.|.|    |      |..   .|..  |                   ... 
dkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv...cttkvqs...................dvll

PTGRIdpnkKEYYSSAQSTLLITHYQFIDWLEY-GPQPPINSLvkfnKIISNQTEHKkgPIVVHCSTGGGRTGAFIG
 |  .     .. .  . |  ..||..  |.|  .|. ....|    .|.   .. |  ..|||||||.||. ||  
ktlel....lstlgeKkkthtvkhysykgWiekndpelareil....nilkvarnsk..slvvhcstGiGrsaafsv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 5-50 9.9e-07 22.6 In-house 80-125 (347) alignment 
Range on Protein: 5-50
Range on HMM: 80-125/347.0
DDEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRI
 |. |..|| || ||  || |||.||   |   .| . . ..|  |
fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
subfamily_PTPN6_pd Subfamily PTPN6 6-223 6.3e-46 151.8 In-house 94-294 (306) alignment 
Range on Protein: 6-223
Range on HMM: 94-294/306.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS-EDYGPFTVTLQKETTSNSFIIRELTLHYNtmmgnlrskivnpt
 .....|||||| |. || |||||||||..  |||.||  |  . ||..|||.  . |.||  .||  .|.. ...|.|||... .              
kgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..............

gridpnkkeyySSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHK----KGPIVVHCSTGGGRTGAFIGMSCS---IKDALTESIIDIPAV
           ......  . .|.| .| . | .   . ...| . .....|.     .|||||||| | ||||.|| . .    |.   ..  |||  .
...........kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqkl

VTIMREQRMMMIQTLDQYMLVHEAVL
| ..||||  ..|| .|| .|..|. 
vksvreqrsglvqteqqykfvykaik
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 6-224 4.1e-44 145.6 In-house 41-237 (237) alignment 
Range on Protein: 6-224
Range on HMM: 41-237/237.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGnlrskivnpt
|   .||||.||||. .  |||.||||||   ||||| | |  ..|| .||||    . || .||.|.|.     . .| |.| ... .           
dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlk..........

gridpnkkeyyssaqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMR
                  ||  |||  | . |      .|..| | | |...|  . || ..|||.| |||| |. . . ...|  . ..||   |  . 
...............evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysie

EQRMMMIQTLDQYMLVHEAVLE
|.|  .||| |||...|...||
edrpyiiqtkdqyvfihqtile
subfamily_PTPRB_pd Subfamily PTPRB 6-95 5.8e-29 96.0 In-house 90-180 (293) alignment 
Range on Protein: 6-95
Range on HMM: 90-180/293.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR-GSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGN
 .. ...|||||||  || |||||||..|. .|||||.| |  ..|| .|||.   .  ||  .|||..|.. . ..||||... .... .
ynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerk
subfamily_PTPN12_pd Subfamily PTPN12 6-91 2.9e-23 77.2 In-house 79-167 (290) alignment 
Range on Protein: 6-91
Range on HMM: 79-167/290.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDY--GPFTVTLQKETTSN-SFIIRELTLHYNT
 |....|||.|||| .|. |||||.|. .   .||. .. |  ..|| .|||..| |.   |.|.|||..| . .  |.|| |... . 
vegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 6-90 9.6e-23 75.5 In-house 60-148 (270) alignment 
Range on Protein: 6-90
Range on HMM: 60-148/270.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE----DYGPFTVTLQKETTSNSFIIRELTLHYN
|....||||..|||. |. .||||.|.||. ||||.|.|.|. | ||..|||..  |     .|  .|. ..|. .. .|...|.|...
dgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleek
subfamily_PTPN13_pd Subfamily PTPN13 6-90 7.3e-21 69.6 In-house 73-160 (273) alignment 
Range on Protein: 6-90
Range on HMM: 73-160/273.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSED---YGPFTVTLQKETTSNSFIIRELTLHYN
...  .|||.||||  || |||.|||. ||  |.|.|. .|. ..|| .|||.. ..    .. ..|.| | .  ..| .|.|... .
gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 6-87 1.4e-20 68.5 In-house 48-128 (239) alignment 
Range on Protein: 6-87
Range on HMM: 48-128/239.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSeDYGPFTVTLQKETTSNSFIIRELTL
|   . |||||| .  .  |||||.|||. | ||||| | |  . || ||||   |  |  . |||.|      .||| . .
dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycnlrvtlrktevfadyiirtfvm
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 6-87 1.4e-20 68.5 In-house 47-127 (239) alignment 
Range on Protein: 6-87
Range on HMM: 47-127/239.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSeDYGPFTVTLQKETTSNSFIIRELTL
|   . |||||| .  .  |||||.|||. | ||||| | |  . || ||||   |  |  . |||.|      .||| . .
dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycnlrvtlrktevfadyiirtfvm
subfamily_CG42327_pd Subfamily CG42327 6-87 4.1e-15 50.3 In-house 68-153 (319) alignment 
Range on Protein: 6-87
Range on HMM: 68-153/319.0
DEQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR----GSEDYGPFTVTLQKETTSNSFIIRELTL
|.    |||.| .|. .  ||||.||. ..  || ||.|.|    .|..|.|..    . . || . |||..  . . ..|  | |
ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll
0050432 (Phosphotyrosine protein) phosphatases II 7-229 1.7e-63 210.1 In-house 105-302 (308) alignment 
Range on Protein: 7-229
Range on HMM: 105-302/308.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR---GSEDYGPFTVTLQKETTSNSFIIRELTLHYNTmmgnlrskivnp
 ...|.|||||||. || |||||||...   |||||||.|. |.|| ||||.    ||. ||.||||| .|.. .....|.|.| ..             
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg............

tgridpnkkeyyssAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTehKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMRE
               . .. .||.....| ..|  | ...|..| ... ..   ..|||||||| | ||||.|| . . .    .|  .|.. .|  .||
..............dgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklRe

QRMMMIQTLDQYMLVHEAVLEQALCG
||..|.||..||.....|.|| ... 
qRpgmvqtpeqylflyralleylklk
subfamily_PTPRK_pd Subfamily PTPRK 7-247 1.7e-61 202.8 In-house 83-298 (314) alignment 
Range on Protein: 7-247
Range on HMM: 83-298/314.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEdYGPFTVTLQKETTSNSFIIRELTLHYntmmgnlrskivnptgr
......|.|||||. || ||||.|..|....|||||.|.|  |.||..|||  ..  ||.. |.| . .. . ...| ....                  
krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek.................

idpnkkeYYSSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRM
          . . . .. ..||. | ...     ..|.|. . . ...|...|.||||||.|.||||.|| ..  .  . .|...|.  .|  .|....
.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkv

MMIQTLDQYMLVHEAVLEQALCGDTQIVACDLQNTISSLSS
 |..| .||.......|| .|||.| | .......  . . 
nmveteeqykfiydvileaclcgetaipvsefkalylesir
0046845 (Phosphotyrosine protein) phosphatases II 7-230 5.9e-61 201.7 In-house 74-278 (284) alignment 
Range on Protein: 7-230
Range on HMM: 74-278/284.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLhyntmmgnlrskivnptg
 ...|.|||||||. || |||||||....  |||||.| |. |.||.||||. | .  ||.||||| .|.. .....|.|.|                  
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtlel..................

ridpnkkEYYSSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTE--HKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTES---IIDIPAVVTI
       ....  . .. .||.....| ..|  | ...|..| ... .. |  ...|||||||| | ||||.|| . . ..   .|.    .|.. .|  
.......tnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkr

MREQRMMMIQTLDQYMLVHEAVLEQALCGD
.||||..|.|||.||..|.||.|| .... 
lreqRpgmvqtleqyrfvyealleylklkl
DSPc_SM00195 7-224 6.2e-58 191.5 In-house 66-260 (263) alignment 
Range on Protein: 7-224
Range on HMM: 66-260/263.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSN-SFIIRELTLHYNTMmgnlrskivnp
....|||||||||. || |||||||.||   |||||. .|. ..||..|||.   |.|..| ..|.|..... . ..|.|.|.| ...            
nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...........

tgridpnkkeyyssaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMRE
               . |  .|.||. .| . | .   .|.... . . .......||||||||.| ||||.|. ... ..   .|. .|| ..|. .|.
...............eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRk

QRMMMIQTLDQYMLVHEAVLE
||..|.|||.||. ..||.||
qRpgmvqtleqYlfiyeaile
PTPc_SM00194 7-224 6.2e-58 191.5 In-house 66-260 (263) alignment 
Range on Protein: 7-224
Range on HMM: 66-260/263.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSN-SFIIRELTLHYNTMmgnlrskivnp
....|||||||||. || |||||||.||   |||||. .|. ..||..|||.   |.|..| ..|.|..... . ..|.|.|.| ...            
nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...........

tgridpnkkeyyssaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMRE
               . |  .|.||. .| . | .   .|.... . . .......||||||||.| ||||.|. ... ..   .|. .|| ..|. .|.
...............eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRk

QRMMMIQTLDQYMLVHEAVLE
||..|.|||.||. ..||.||
qRpgmvqtleqYlfiyeaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-233 5e-51 168.7 In-house 96-297 (298) alignment 
Range on Protein: 7-233
Range on HMM: 96-297/298.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVtlqkettsnsfiireltlhyNTMMGNLRSKIVNPTGR
.... .||||.|| .||.||||||..|.. .|||||.|.|  ..|...|||..|.| || .||                    . .  .  ..... .  
kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv....................sllskeefadlivrklk

IDPNKKEyyssaqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIIS-NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQR
.  .|.|      ..  . . .|. | . |     .|.... . .  .|.. .. |..|.|| | ||.|.|| ..  .  . .|. .|.  || ..|..|
vskkkee......kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkr

MMMIQTLDQYMLVHEAVLEQALCGDTQI
. ..|| .||. ..|||||   .....|
pgavqteeqYvfiyeavlealdsfndei
subfamily_PTPN1_pd Subfamily PTPN1 7-230 4.8e-40 132.1 In-house 68-277 (290) alignment 
Range on Protein: 7-230
Range on HMM: 68-277/290.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE-----DYGPFTVTLQKETTSNSFIIRELTLHYntmmgnlrskiv
|  ..|| ||||| .||  ||.|||..|. |.||| |. |  .||| ||||.  .|     .   ..|.| .| ... ...| | |.             
eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen............

nptgridpnkkeyySSAQSTLLITHYQFIDWLEYG-PQPPiNSLVKFNKII--SNQTEHKKGPIVVHCSTGGGRTGAFIGMSCS---IKDALTESIIDIP
               ..| |  |.|. .. | ..| |. | ....||   .  |    ...|| |.|||.| ||.|.|. . .    |..    | .|| 
..............lktqetreilhfhyttwpdfgvpesp.aaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdik

AVVTIMREQRMMMIQTLDQYMLVHEAVLEQAL--CGD
 |.  .|..|. .||| ||  . . |.|| |    ||
kvllelrkyrlGliqtadqlrfsylaileGakvikgd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-92 7.9e-30 98.7 In-house 88-173 (290) alignment 
Range on Protein: 7-92
Range on HMM: 88-173/290.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTM
.....|||||||. .|.||||...|||| ..|||||. .|. . || ||||......||.|...|..|.| |..|.|.| .. .. 
kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkns
subfamily_PTPN3_pd Subfamily PTPN3 7-91 5.6e-28 92.7 In-house 81-166 (280) alignment 
Range on Protein: 7-91
Range on HMM: 81-166/280.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLHYNT
.....||||||||..|. |||.|||..|.  ||||| | |. |.|| ||||. . . .|| |.|...|| ...|...|||.|. ..
glvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 7-89 8.9e-28 92.3 In-house 86-170 (305) alignment 
Range on Protein: 7-89
Range on HMM: 86-170/305.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQKETTSNSFIIRELTLHY
....|||..||||. ||.||||....||   |||||||.|. . || |||| . .|  ..|.|.|.|. |.| . .|.|.|..  
krkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 7-92 2.3e-25 84.3 In-house 50-133 (250) alignment 
Range on Protein: 7-92
Range on HMM: 50-133/250.0
EQsQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIkCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTM
|. . .||||||| .|..||||||..||. .|||||.|.|  .  ..||||  ..| ||  ||.| .. .   ...|.| |  .. 
er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadytkrklklskakk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-89 1.6e-23 78.2 In-house 81-164 (281) alignment 
Range on Protein: 7-89
Range on HMM: 81-164/281.0
EQSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLHY
.. ..|||||||.  ..|.||.|||..|..||||.|.  |  ..|| .|||    .  || .||. ..|......| |...|. 
kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkler
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 7-87 1.5e-07 25.8 In-house 32-105 (255) alignment 
Range on Protein: 7-87
Range on HMM: 32-105/255.0
EQSQKYIAtqgpldrTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTL
.. . |.        ||  |.... | |.  .|||. ..|. . |||.|.|    |      |..    .|.  ..| |..
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei
subfamily_PTPRD_pd Subfamily PTPRD 8-302 1.3e-81 269.9 In-house 89-359 (564) alignment 
Range on Protein: 8-302
Range on HMM: 89-359/564.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTmmgnlrskivnptgri
....|||||||| .|. |||||||... . |||||||.|  . ||..|||..|.| || .||||..|.. . ..||...|. ..                
krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk................

dpnkkeyyssAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMM
           ...  .....|..| . |     .||... . ... .|...|||||||| | ||||.|| ... .. . .|  .||  .|. .|.|| .
..........ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRna

MIQTLDQYMLVHEAVLEQALCGDTQIVACDLQNTISSLSSSD-NASVTGFEAQFNVLE-QVSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKS
|.|| .||. .|||.||   ||.|.. . .|..... |.. . . ..||.|. |. |.  . .....  .    .  .|||...||.... || |. 
mVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsa
0051299 (Phosphotyrosine protein) phosphatases II 8-225 1.4e-62 207.2 In-house 90-285 (288) alignment 
Range on Protein: 8-225
Range on HMM: 90-285/288.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGnlrskivnptgri
...|.|||||||. || |||||||...   |||||||.|. |.|| ||||..||. ||..|||| .|.. .....|.|.. ......             
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld.............

dpnkkeyysSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMM
           . .. .||.....| ..|  . ...|..| ... .. ....||.||||| | ||||.|| . . .   ..|  .|.. .|  .||||..
.........gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg

MIQTLDQYMLVHEAVLEQ
|.||..||..|.||.|| 
mvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 8-241 7.6e-61 201.5 In-house 84-291 (317) alignment 
Range on Protein: 8-241
Range on HMM: 84-291/317.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYN-Tmmgnlrskivnptgr
...|.|||||||. || |||||||... . |||||.| |. |.|| ||||....  ||.|||||..|.. .....|.|.. .. .               
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd...............

idpnkkeyyssaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRM
            . .. .||.....| ..|. | ...|..| ... .. |...||..|||| | ||||.||.. . .    .|  .|.. .|  .||||.
............sesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRp

MMIQTLDQYMLVHEAVLEQALCGDTQIVACDLQNT
...||..||. ...|.||  ....| . |..| . 
gavqtpeqyrflydalleylkrkltlepaselklk
0036941 (Phosphotyrosine protein) phosphatases II 8-238 1.7e-60 200.2 In-house 76-289 (297) alignment 
Range on Protein: 8-238
Range on HMM: 76-289/297.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETT--SNSFIIRELTLHYNTMmgnlrskivnp
...|.|||||||. || |||||||...   |||||.| |. |.|| ||||.   .|  ||.|||||.....  ......|.|.. ..             
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn...........

tgridpnkkeyyssaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDAL---TESIIDIPAVV
               . .. .||.....| ..|. . ..||..| . . .. ..  ..||..|||| | ||.|.||.. . .       .|  .||. .|
...............gesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileav

TIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIVACDL
  .||||....|||.||. ..||.||  ....| . ...|
kklReqRpgavqtleqyrflyeallellkkkltkepllkl
0047943 (Phosphotyrosine protein) phosphatases II 8-224 1.2e-59 197.3 In-house 75-270 (273) alignment 
Range on Protein: 8-224
Range on HMM: 75-270/273.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG---SEDYGPFTVTLQKETTSNSFIIRELTLHYNTmmgnlrskivnpt
...|.|||||||. || |||||||....  |||||.|.|. |.|| ||||. |   |. ||.||||| .|.| .....|.|.| ..              
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.............

gridpnkkeyyssAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMR
              . .. .||... .| ..|  | ..||..| ... .. |.  ..||.||||| | ||||.|| . . .    .|  .|.. .|  .|
.............tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

EQRMMMIQTLDQYMLVHEAVLE
.||..|.||..||....||.||
sqRpgmvqtpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 8-224 2.4e-57 189.8 In-house 86-275 (278) alignment 
Range on Protein: 8-224
Range on HMM: 86-275/278.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPsRGSEDYGPFTVTLQKETTSNSFIIRELTLHYN--Tmmgnlrskivnptg
...|.|||||||. || |||||||...   |||||.| |. |.|| |||| .||. ||.|||||.||.. . ...| |.....                 
vprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdg..............

ridpnkkeyyssaqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQR
               .. .|||....| ..|  .....|..| |.. .. |...||..|||| | ||||.||..   .  . .|  .|.. .|  .||||
..............esrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR

MMMIQTLDQYMLVHEAVLE
....||..||. ..||.||
pgavqtpsqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 8-224 4.9e-57 188.4 Pfam-A 40-235 (235) alignment 
Range on Protein: 8-224
Range on HMM: 40-235/235.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWP--SRGSEDYGPFTVTLQ-KET-TSNSFIIRELTLHYNTMMGnlrskivnp
...|.|||||||. |. ||||||||||  .|||||.|.|  | ||.||||  ...|. || ..|.|. ||.  ......|.|.|. ..            
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.........

tgridpnkkeyyssaqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMRE
                 .  ...... .| ..| .   .||... . . ...|.|.||.|||||.| |||| |. ... .. . .|. .|.  .|  .|.
................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRk

QRMMMIQTLDQYMLVHEAVLE
||..|.|.|.||. ...|.||
qRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 8-224 4.9e-57 188.4 In-house 40-235 (235) alignment 
Range on Protein: 8-224
Range on HMM: 40-235/235.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWP--SRGSEDYGPFTVTLQ-KET-TSNSFIIRELTLHYNTMMGnlrskivnp
...|.|||||||. |. ||||||||||  .|||||.|.|  | ||.||||  ...|. || ..|.|. ||.  ......|.|.|. ..            
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.........

tgridpnkkeyyssaqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMRE
                 .  ...... .| ..| .   .||... . . ...|.|.||.|||||.| |||| |. ... .. . .|. .|.  .|  .|.
................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRk

QRMMMIQTLDQYMLVHEAVLE
||..|.|.|.||. ...|.||
qRpgmvqsleqYiflykaile
0045450 (Phosphotyrosine protein) phosphatases II 8-224 2.1e-55 184.0 In-house 105-302 (307) alignment 
Range on Protein: 8-224
Range on HMM: 105-302/307.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE-DYGPFTVTLQKETTSNSFIIRELTLHYNTMMGnlrskivnptgr
...|.|||||||. || |||||.|...  .|||||.| |. |.|| ||||. |.|  ||.||||| .|.. .....| |.....   |            
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg............

idpnkkeyyssaqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESI---IDIPAVVTIM
              .. .||.....| ..|  | ...|..| ... .  |.  |.||..|||| | ||||.||..   ..   .| .   .|.. .|  .
.............esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkll

REQRMMMIQTLDQYMLVHEAVLE
||||. ..|...||. ..||.||
reqRpgavqnpeqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 8-224 2.7e-53 176.5 In-house 52-244 (249) alignment 
Range on Protein: 8-224
Range on HMM: 52-244/249.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTmmgnlrskivnptgri
.....|||||||. || |||||.|...  .|||||.|.|  |.|| ||||..||  || ||||| ..........|.|.|...                 
ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnly................

dpnkkeyyssAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQR
           .... ..|.|..|| ..|  | ...|..| ... .  |.  |.||..|||| | ||||.||..   .    .|  .|.. .|  .|.||
..........dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR

MMMIQTLDQYMLVHEAVLE
....|...||. ..||.||
pgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 8-224 9.8e-52 171.1 In-house 50-241 (245) alignment 
Range on Protein: 8-224
Range on HMM: 50-241/245.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYN-Tmmgnlrskivnptgr
...|.|||||||. || |||||.|...  .|||||.. |. |.|| ||||...|  || ||||| .|.. .....|.|..... .               
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgd...............

idpnkkeyyssaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTE-HKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQR
              .. ..||....| ..|. . ...|..| ... .. . ...||..|||| | ||||.||..   .  . .|  .... .|  .|.||
............desrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR

MMMIQTLDQYMLVHEAVLE
....||..||. ..||.||
pgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 8-245 2e-51 169.9 In-house 89-305 (307) alignment 
Range on Protein: 8-245
Range on HMM: 89-305/307.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTM-MGNLrskivnptgr
...|.|| |.|.. |. |||||... .   ||||..|.|  | ||..|||      ||   |.| .| . . .||||| .  .    |..          
ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev..........

idpnkkeyyssaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRM
            . .  .. |..  | ..      ..|.|. . . .  .....|||||||.| ||.| |. ..  ..   .|  .|| ..|  .|.|| 
............edsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRn

MMIQTLDQYMLVHEAVLEQALCGDTQIVACDLQNTISSL
...| |.||. .. |.|.    |||..   ||...| .|
llvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_PTPRG_pd Subfamily PTPRG 8-240 7e-51 168.1 In-house 89-301 (563) alignment 
Range on Protein: 8-240
Range on HMM: 89-301/563.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIReltlhyntmmgnlrskivnpTGRI
.|...|||||||  |. |||||.|....  |||.|.|.|. | || .|||. .||.|| ..|||..| .  .  .|                    |  |
kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr....................tlvi

DPNKKEYYSSAQSTLLITHYQFIDWLEYGpqPPINSLVKFNKIISNQT--EHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQR
   |..  ..... .|...|.. .| . |   |  || . . .. ...  ... ||||||||.|.|||| .| ..  .|.  .|.....  ..  .| ||
knlklkkkkqcdteklvrqyhytkWPdhg..vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqR

MMMIQTLDQYMLVHEAVLEQALCGDTQIVACDLQN
 ...|| .||. .|.|.||  . ..|...| ....
nflvqteEqYiflhdalleaiasketellaeqvee
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 8-224 6.5e-50 164.5 In-house 83-291 (301) alignment 
Range on Protein: 8-224
Range on HMM: 83-291/301.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPS--RGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGnlrskivnpTG
...|.||.|||...|.|||||..||||  .|||.|.|.|. . || ||||.    ||..|||||||..|..  .|.||.|... .   .          |
ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsn.........ng

RIDPN------KkeyyssaqSTLLITHYQFIDWLEYGP-QPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVV
.|  .      |        |.  .. .| .|| . |  . |   |   ...|  |    .||.||||| . .|.| .. .| ..  .  | ..|.  |.
yierkfkvksdk........sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvt

TIMREQRMMMIQTLDQYMLVHEAVLE
  .| ... ...||.||. ..... .
kavrrskpgaVtTLeqytsiydvidm
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 8-89 1e-30 101.9 In-house 87-168 (318) alignment 
Range on Protein: 8-89
Range on HMM: 87-168/318.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHY
....|||.|.|| .|. |||||||. ... |||||...|  ..|. .||||.||. ||  .|.|..|........||.... 
rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr
subfamily_PTPRA_pd Subfamily PTPRA 8-88 3.5e-29 96.7 In-house 99-179 (330) alignment 
Range on Protein: 8-88
Range on HMM: 99-179/330.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLH
. .|.||.|||...|| |||||.|. |...|||||.|.|  . || ||||. |.  ||  .|....|| .... .|.. ..
ekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 8-216 1e-28 95.0 In-house 88-271 (301) alignment 
Range on Protein: 8-216
Range on HMM: 88-271/301.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSedygpftvtlqkettsNSFIIRELTLHYNTMMGNLRSKIVNPTGRI
.....|||||||. |  ||| |. | .   ||||..  |.|  ||..| |.. |                ... |   ... ...   |. ||.. | ..
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis................ekldigrfkikiknkelilnkkiskrtlev

DPNKKEYyssaqSTLLITHYQFIDWLEYGPqpPiNSLVKFNKIIsNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMM
    ...     .|  .||||. .| ..|   | .| ..  ... .   . . |||||||.| ||. ||||  .  .. ...  |..   .  .||.|  
edstgkf.....atrtvthyqysewtdrgv..P.kshaelfdlm.elvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwn

MIQTLDQYM
 .||  |  
gvqtnsqly
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 8-92 5.2e-28 93.0 In-house 89-171 (319) alignment 
Range on Protein: 8-92
Range on HMM: 89-171/319.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLhyNTM
. .|.||||.||. |. |||||||.|..  .||||||.| |..|...|||.   |.|| ..|||..|   . .|||.|.|  |. 
erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl..nkk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 8-92 2.2e-25 84.2 In-house 84-168 (287) alignment 
Range on Protein: 8-92
Range on HMM: 84-168/287.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTM
.....|....|. .|...||.......  |||||....|. . .| ||||.  |  .|.....| .|......|.|.| .. .. 
ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknk
subfamily_PTPN9_pd Subfamily PTPN9 8-90 3.2e-24 80.5 In-house 83-167 (297) alignment 
Range on Protein: 8-90
Range on HMM: 83-167/297.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWP--SRGSEDYGPFTVTLQKETTSNSFIIRELTLHYN
| . .|||||||..|| |||||||....  ||| |.. |  |.||.||||  .  |...| ..|.  .  ... . .| |...  
qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 8-98 3.9e-24 80.6 In-house 66-150 (284) alignment 
Range on Protein: 8-98
Range on HMM: 66-150/284.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTklqedlRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGNLRS
. .|||||||||| |. |||||.|. ....||.||      . ||||||| .. . .. | | ..  . |. ...|.. |  .. . . |.
rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirk
subfamily_PTPN14_pd Subfamily PTPN14 8-90 1.5e-21 71.6 In-house 91-177 (300) alignment 
Range on Protein: 8-90
Range on HMM: 91-177/300.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS----EDYGPFTVTLQKETTSNSFIIRELTLHYN
....||..||||. || |||.|||...   |||||. .|| . |. .|.|. .|     ..| | || .  ..|.|.| . |.|.. 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 8-88 2.1e-21 71.2 In-house 90-169 (315) alignment 
Range on Protein: 8-88
Range on HMM: 90-169/315.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRgSEDYGPFTVTLQKETTSNSFIIRELTLH
. ..|||.|||.  .| ||||.|..|.   |||||.| |. . |. .||| .    ||..|||...|   . . .| |.  
kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv
subfamily_ptpA1_pd Subfamily ptpA1 8-180 1.6e-20 68.3 In-house 87-250 (418) alignment 
Range on Protein: 8-180
Range on HMM: 87-250/418.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR-GSEDYGPFTVTlqkettsNsfiirELtlhYNTMMGNLRSKIVNPTGR
  ...|.|||||  |. |||||||....  ||||..  |. |||| .||| . | |..  .          |     |.   . |   .|   | .|   
ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygng.......n.....ev...fgtysvelveviqdpere

IDPNKkEYYSSAQSTLLITHYQFIDWLEYGPQ---PPINSLV-----KFNKIISnqTEHKKGPIVVHCSTGGGRTGAFIGMS
|   .    .    |  ||.||.  | ..       |.  |.     . |.||   .  .. ||.||||.| ||||.|    
iitrn.irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiip..ssdrnvpiivhcsagvgrtgtfctav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 8-86 8.7e-17 55.8 In-house 78-158 (287) alignment 
Range on Protein: 8-86
Range on HMM: 78-158/287.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE-DYGPFTVTL-QKETTSNSFIIRELT
. ...||.|||.  || ||||.|...........|.  |. | || .||| |      | ..|.| ...  .  . .| | 
ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 8-83 1.2e-12 42.4 In-house 74-152 (285) alignment 
Range on Protein: 8-83
Range on HMM: 74-152/285.0
QSqKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQ--KETTSNSFIIR
||  ||.|||||  |. |||.|..||| . ..||  | |    ||. |.| .  |   .| . .||   || .    |. 
qs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtiln
subfamily_eak_pd Subfamily eak 8-88 7.6e-09 29.4 In-house 91-173 (332) alignment 
Range on Protein: 8-88
Range on HMM: 91-173/332.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG--SEDYGPFTVTLQKETTSNSFIIRELTLH
  .||| |  . .  |  ||.|| ..|. |||.| .  |    |  .|.| ..    ..| . |. ..    | .  | | |.
vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllels
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 8-60 1.4e-07 25.8 In-house 80-132 (288) alignment 
Range on Protein: 8-60
Range on HMM: 80-132/288.0
QSQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG
  .. | .| ||. |.  .|.|. ..    ||||..| |  . |  .|.||. 
ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl
0039614 (Phosphotyrosine protein) phosphatases II 9-229 1.8e-56 187.2 In-house 100-292 (297) alignment 
Range on Protein: 9-229
Range on HMM: 100-292/297.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRiKCSQYWPSRGSeDYGPFTVTLQKETTSNSFIIRELTLhyntmmgnlrskivnptgrid
..|.|||||||. || |||||||...  .||||||| |. | || ||||..|.  ||.||||| |... . ...|.|..                     
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlev.....................

pnkkeyySSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRM
       .  . .. .||.|...| ..|. | ...| .| ... .. ..  |.||..|||| | ||||.||..   .    .|  .|.. .|  .||||.
.......tnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRp

MMIQTLDQYMLVHEAVLEQALCG
...||..||. ...|.||  ...
gavqtpsqyrflydallellkrk
0045098 (Phosphotyrosine protein) phosphatases II 9-230 1.3e-54 180.8 In-house 63-276 (278) alignment 
Range on Protein: 9-230
Range on HMM: 63-276/278.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGNLrskivnptgrid
..|.|||||||. || |||||.|...  .|||||.|.|. |.|| ||||..||. ||.|||||..|.. . ...| |.... |.. .             
pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltvered............

pnkkeyyssaQSTLLITHYQFIDWLEYGPQPPI--NSLVKFNKIISNQTEH-------------KKGPIVVHCSTGGGRTGAFIGMSCSIKDAltESIID
            .. .||.... | ..|. .    .|. .. . | .  ..             ..||..|||| | ||||..... . ..    |. .|
..........lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvd

IPAVVTIMREQRMM-MIQTLDQYMLVHEAVLEQALCGD
.. .|. .|.||.. ..|.|.||. ..|..||  |.|.
lleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 9-251 1.5e-44 147.1 In-house 86-302 (315) alignment 
Range on Protein: 9-251
Range on HMM: 86-302/315.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTlhyntmMgnlRskivnptgr
 . |||.||||. .| ||||||.|||. .|||.||.||. .||| |||| |   | ..| . |.| .  .    ..|.|.      .   |         
dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklv......t...r.........

idpNKKEYYSsaqstllITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRM
   . .|.         .| .|| .| . | .    ||.|. | .  . ..|. ...||||.| |||| .| .   ....  .. .|.  .|...|..|.
...kseesrt.......vtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrp

MMIQTLDQYMLVHEAVLEQALCGDTQIVACDLQNTISSLSSSDNA
 ..|| ..| ....||||. |  .| |.   . . .  | .| ..
ylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdg
subfamily_CG7180_pd Subfamily CG7180 9-230 7.4e-39 128.1 In-house 84-294 (296) alignment 
Range on Protein: 9-230
Range on HMM: 84-294/296.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRiKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNtmmgnlrskivnptgrID
 ..|| |..| ..|| .|||.|..|.. |.|.|||  .  . .. .||| .. |.||.. | . .| .   . ||.. |  .                | 
kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkk................iv

PNKKEYYSSAQSTLLITHYQFIDWLEYGPQPPI-NSLVKFNKIISNQTEH-----KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMR
   ..       | .....|.  |      | . |.|... . .    |.     ..||.||..| |..|.|.....  ..  .  |  .|.   |  .|
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

EQRMMMIQTLDQYMLVHEAVLEQALCGD
..|  .... ..|. . . .||  ||. 
rsRpqLvenveeYkyiYdvlleavlcnk
0041856 (Phosphotyrosine protein) phosphatases II 9-231 5.8e-36 119.2 In-house 33-176 (182) alignment 
Range on Protein: 9-231
Range on HMM: 33-176/182.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTklqedlrikCSQYWPsrgsedygpftvtlqkettsN-Sfiireltlhyntmmgnlrskivnptgri
....|||||||..|| ||.||.....  .||.||         . .|||                    .                              
atrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................ell............................

dpnkkeyyssaqsTLLITHYQFIDWLEYGPQPpINSLVKFNKIISNqtehKKGPIVVHCSTGGGRTGAFIGMSCSIKDalteSiIDIPAVVTIMREQRMM
             . |...|... |  .|. . ...|..| ... .    ..||..|||| | ||||.....   .|     . .... .|  .|..|..
.............erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpg

MIQTLDQYMLVHEAVLEQALCGDT
|..|..|| ... |.||  |...|
mvitpnqyfflqlallellllkkt
0036282 (Phosphotyrosine protein) phosphatases II 9-220 1.1e-35 118.2 In-house 16-164 (174) alignment 
Range on Protein: 9-220
Range on HMM: 16-164/174.0
SQKYIATQGPLDrtvvdFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSrgsedygpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgrid
. ..||.||||.     ||.|.....  ..|||....|. . || .|||.                                                  
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................................

pnkkeyySSAQSTLLITHYQFIDWLEYGPQPPINsLVKFNKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALtESIIDIPAVVTIMREQRMM
        .   . |. .|... |  .|. .    | .| |.. .  .. ..||..|||| | ||||.....   ..  | || .|. ..|  .| ||..
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpg

MIQTLDQYMLVHE
|.|| .||. ...
mvqtpsQyrflyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 9-254 3.4e-35 116.2 In-house 87-264 (392) alignment 
Range on Protein: 9-254
Range on HMM: 87-264/392.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLrikcsqywpsrgsedygpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgrid
 . |||.|||   .. ||||||.||....|.|.|||.|                                                              
ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............................................................

pnkkeyysSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMM
          ...  .. ..| .| . .     .||.|| | .. .  .   |...|||.| ||||  | . . .  | .  ..|.  .|| .|..| .|
........kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpym

IQTLDQYMLVHEAVLEQALCGDTQIVACDLQNTISSLSSSDNASVT
.|| .|| ... ||||. |  .| |    . . .. ||.| .  |.
vqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvr
0049260 (Phosphotyrosine protein) phosphatases II 9-220 1e-34 114.8 In-house 8-144 (152) alignment 
Range on Protein: 9-220
Range on HMM: 8-144/152.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWpsrgsedygpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgrid
....||||||.. |. |||||... .. .|||||.|.|. ..|| ||.                                                    
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....................................................

pnkkeyyssaqstllitHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIkdalteSIIDIPAVVTIMREQRMMM
                 .|... |  .|... .  |  ....|    ..|.||..|||| | ||||... .   .        ...  .|  .||.|...
.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpga

IQTLDQYMLVHE
... .|.....|
vpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 9-225 1.4e-31 104.6 In-house 81-276 (307) alignment 
Range on Protein: 9-225
Range on HMM: 81-276/307.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDygpfTVTLQKettSNSFIIReltlhyntmmgNLRSKIVNPTGRID
 .|.|..||||. |. .|| |. |||  ...|| |. |  .||| ||||    .      |  ..   .|.  .            || .| . |   . 
pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk....lvfgea...pntisva...........nlgakklapdedli

PNKKEYYSSAQSTLLITHYQFIDWLEYGpQPPINsLVKFNKIisNQTEHKKGPIVVHCSTGGGRTGAFIGMSCsIKDALT--ESIIDIPAVVTIMREQRM
   .     || .  |.|.|. .| . |  |.|| |   | .  . .. .. |.|||||.| ||.|. ...|  ..| .   .   |.  .|  .|.|| 
nvttlkvdwaqksrtiqhlqwenwpdrg.vpqin.ltainll..eavrydtnpvvvhcsaGvGrsGtivaisl.vqdkmiaGinckdmkklveelrsqrh

MMIQTLDQYMLVHEAVLEQ
  |||  ||. .|  .|| 
yaiqteaqylylhrvlley
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 9-224 6.6e-29 95.6 In-house 87-285 (305) alignment 
Range on Protein: 9-224
Range on HMM: 87-285/305.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGsEDYGPFTVTLQKETtsnsfIIRELTLHYnTMMGNLRSKIVNPTGRID
....| || ||..|  ||| | .|.|  || || .|.|    ||..|..|.  .|   |    || .     .  | .  .  .  . ..|. .    |.
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kdvlefeekgqkis.....vkfessvtl.kfrkdakakvtetvlvie

pnkkeyySSAQSTLLITHYQFIDWLEYGPQPPINSLVKfnkiISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIID-IPAVVTIMREQRMM
        . .... .||| .||| . |  .  .....    . ...   |||||||||.| ||||. . .   ... |.  ||.    ..  .||||  
.......gpgekarkvthyhwidwpdrgvpaadlaile....llekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnn

MIQTLDQYMLVHEAVLE
 ||| .||..||. .|.
siqtdaqylfvhqviln
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 9-98 2.5e-24 81.2 In-house 103-186 (319) alignment 
Range on Protein: 9-98
Range on HMM: 103-186/319.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTklqedlRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGNLRS
 .||||.||||| |. |||||.|. ....||.||      . ||||||| .. . .. | | ..  . .. ...|.. |  .. . . |.
kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirk
subfamily_PTPN23_pd Subfamily PTPN23 9-91 9.9e-23 75.3 In-house 82-166 (288) alignment 
Range on Protein: 9-91
Range on HMM: 82-166/288.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS--EDYGPFTVTLQKETTSNSFIIRELTLHYNT
. ..||||.||. |. |||.||...|.  ||||.. .|  . |...|||..    . .|...|||....... .. |.|.|. . 
cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 9-224 1.4e-18 61.3 In-house 106-342 (349) alignment 
Range on Protein: 9-224
Range on HMM: 106-342/349.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSrgsEDYGPFTVTLQKeTTSNSFIIRELTLHYNTMMGNLRSKIVNPTGRID
 .|||||| ||  || ||....  ..   .. |.. .|    || .||      .|  .|| ||  .  ..  ..  .|.. |   .      |    ..
ekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe...lsysnitvklqn.sslyianvqGnslrvstvkdtdndndnnkknCdl

PNKKEYYS---SAQSTLLITHYQFIDWLEYG----PQPPINSLVKFNKIISNQT------EHKKGPIVVHCSTGGGRTGAFIGMSCSIK--DALTESI--
|.. .  .   . ..   .   |. .||. .    |.  ...|   |..| ..       . .  ...||||.| |||| .. .   .     |..    
pddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnk

ID--------IPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
|.        |  .| ..| ||. |.| | |.. ..||.|.
iklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 9-92 3.8e-13 44.1 In-house 4-89 (199) alignment 
Range on Protein: 9-92
Range on HMM: 4-89/199.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHYNTM
 ..||||| ||  |. |||.|||.  .  |||.   | .     . |||.   |.  || ..|| .  ||   . |  | |  || 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 9-91 2.4e-09 31.6 In-house 71-152 (267) alignment 
Range on Protein: 9-91
Range on HMM: 71-152/267.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlriKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHYNT
 ...|.||.||. |. ||. .. ..|   ||.|||  .|   .  ..|| .   .. |  .||    |   | . |  | |... 
knafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 9-56 6e-06 20.2 In-house 81-128 (312) alignment 
Range on Protein: 9-56
Range on HMM: 81-128/312.0
SQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYW
 .....|||||. |.. ||...    ...|..|. . ||   ||..| 
perfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi
0051429 (Phosphotyrosine protein) phosphatases II 10-225 6.7e-37 123.0 In-house 22-224 (272) alignment 
Range on Protein: 10-225
Range on HMM: 22-224/272.0
QKYIATQGPLDRTVVDFWRMvWQEKACAIVMLTKLQEDLRIKCSQYWP------------SRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMmgnlr
 ......|||. |. ||||. ....  .||.|... |  | ||..|||            |  .  || ..|||..|.. . .|.|||.|..        
grlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltllls.....

skivnptgridpnkkeyyssAQSTLLITHYQFIDWLEYGPQPPInsLVKFNKIISNqtehkKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIID----
                    |. .. ..|....||. .|  .    |... ... .     .||..|||| | .||| .. .  .. .   | |.|    
....................agearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----IPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
    . ..|  .|.||. ..|| .||. ..||.|| 
tnlyleeaveelraqrpgavqteeqylflyeallel
0046846 (Phosphotyrosine protein) phosphatases II 10-224 1.5e-35 117.9 In-house 23-171 (176) alignment 
Range on Protein: 10-224
Range on HMM: 23-171/176.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYgpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgridp
 ..||||||| ||. ||..|.....  |.|.||...|  |.|| .|||   ....                                             
srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................................

nkkeyyssaqstllitHYQFIDWLEYGPQPPiNSLVKFNKIISNQTEHKkGPIVVHCSTGGGRTGAFIGMScsikdaLTES--IIDIPAVVTIMREQRM-
                .|....| ..|. .  . | .. ..| .. ... ||..|||| | ||||... .       | |.   ...  ..  .||||. 
................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay......llelekglsveealalvreqRpl

MMIQTLDQYMLVHEAVLE
...|| .||  ..|..|.
gavqtpeQyrflyefell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 10-237 1.6e-34 114.2 In-house 91-290 (439) alignment 
Range on Protein: 10-237
Range on HMM: 91-290/439.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRikcsqYWPSRGSEDYGPFTVTLQKETTSNSFIIRELtlhyntmmgnlrsKIVNptgRIDP
. ||||||| . |. ||||.|...|.  |||||.| |  .     |||| .   ||  .|  ...     ..|| .             |..|   . | 
klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgf.............kvfn...erdt

NKKEyyssaqSTLLITHYqfIDWLEYGPQPPINSLVKF-NKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMM
..||       |.|  ||  | | .         ...|   | | . ... ||.|||||.| ||||. | .  ....  .|  .||  .|...|.||  |
teke......rtvlqfhy..iawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqm

IQTLDQYMLVHEAVLEQALCGDTQIVACD
.|.| ||.....||||.   ||. ..  .
vqalcqyvfiynavledivyGdiavtide
0043147 (Phosphotyrosine protein) phosphatases II 10-220 1.3e-33 111.6 In-house 20-155 (172) alignment 
Range on Protein: 10-220
Range on HMM: 20-155/172.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLqedlrikcsqywpsrgsedygpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgridp
...|||||||..|. |||||.....  .||.||.|                                                                 
drfiatqgplrntladfwrmlkelgithivnltel.................................................................

nkkeYYSSAQSTLLITHYQFIDWLEYGPQpPINSLVKFNKIISN-QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIkdaltE-SiiDIPAVVTIMREQRMM
    .|   . . |. .|... |  .|.. ... | .| ..| . . . ..||..|||| | ||||... .   .     .    ..  .|  .||.|..
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl..sleeavalvrekRpg

MIQTLDQYMLVHE
..|. .||.....
avqnpsqyrflyy
0049772 (Phosphotyrosine protein) phosphatases II 10-224 8.5e-28 93.4 In-house 84-278 (314) alignment 
Range on Protein: 10-224
Range on HMM: 84-278/314.0
QKYIATQGPLDRTVVDF----------WRMV--WQEKACAIVM---------------------LTKLQEDLrikcsQYWPSRGSEDYGpftvtlqkett
.|.|||||||. |||||          ||||  .. .   |||                     |..| .        ... .  |..            
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........

snsfiireltlhyntmmgnlrskivnptgridpnkKEYYSSAQSTLLITHYQFIDWLEyGPQPPINSLVKFNKIISNQteHKKGPIVVHCSTGGGRTGAF
                                   .|.|.    . |. .|  |..   | .|... . .| ..| .   .|.||..|||. | |||| |
...................................eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtf

IGMSCSIKDAlteSIiDIPAVVTIMREQRM-----MMIQTLDQYMLVHEAVLE
. . . .|      . ..  ..  .|..|.      .|..|.||  ..||.||
vvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 10-89 2.3e-21 70.5 In-house 86-167 (515) alignment 
Range on Protein: 10-89
Range on HMM: 86-167/515.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPS--RGSEDYGPFTVTLQKETTSNSFIIRELTLHY
. |||.|||.. .| ||||.|.||.  .|.|.|||.|. .|||..|||     |  .| . | |    .    |.|.||.  
kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 10-91 4.4e-21 70.3 In-house 92-172 (297) alignment 
Range on Protein: 10-91
Range on HMM: 92-172/297.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRiKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHYNT
...|.|| | . || |||.||..|.. .||||....|  . || .||. .|.  .|  .|.|.  .  . || |||..  . 
hrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 10-87 2.4e-19 64.1 In-house 94-171 (310) alignment 
Range on Protein: 10-87
Range on HMM: 94-171/310.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETtSNSFIIRELTL
. .| .||||. |..|||||..||.| .|..| |  |. | ||  |||| | .| ||   ||   |. |. | | .|..
stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 10-85 2.9e-18 60.5 In-house 94-172 (290) alignment 
Range on Protein: 10-85
Range on HMM: 94-172/290.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQKETTSNSFIIRE-L
  .| |||.|  ||.|.|||| |||. ||||| .| || . ||.||.| .  |   .| .||.  .|.. .. ||.  |
amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 10-97 4.3e-16 53.3 In-house 236-321 (440) alignment 
Range on Protein: 10-97
Range on HMM: 236-321/440.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlriKCSQYWPSR-GSEDYGPFTVTLQKETTSNSFIIRELTLHYNTMMGNLR
. .|||| ||| ||.||||.| . .  .|.|| .|..     || |||    |  .|||||  .     |   .| | |.|.  . ..|
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheir
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 10-91 6e-16 52.9 In-house 81-164 (281) alignment 
Range on Protein: 10-91
Range on HMM: 81-164/281.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHYNT
. || ||||   |  |||||.|||.. ||||| .. |  | ||..|.|       ..  ..|. .  |  .|..   | | |. 
rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeg
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 10-61 8.5e-15 49.2 In-house 96-147 (305) alignment 
Range on Protein: 10-61
Range on HMM: 96-147/305.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS
...|..|||||.|. .|| || |.|   |||| |  |  ..||.||||    
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 10-92 4.1e-13 44.0 In-house 4-88 (198) alignment 
Range on Protein: 10-92
Range on HMM: 4-88/198.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHYNTM
..||||| ||  |. |||.|||.  .  |||.   | .     . |||.   |.  || ..|| .  ||   . |  | |  || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt
0037934 (Phosphotyrosine protein) phosphatases II 11-224 2.5e-50 166.6 In-house 45-240 (243) alignment 
Range on Protein: 11-224
Range on HMM: 45-240/243.0
KYIATQGPLDRTVVD----FWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPsrGSEDYGPFTVTLQKETTSNSFIIRELTLHyntmmgnlrskivnptgr
..|||||||. || |    ||||.|...  .|||||.|.|  |.|| ||||  |.. ||.||||| .|.. .....|.|.|                   
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehlddytvrtllle..................

idpnkkeYYSSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQ--------TEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDAlteSiIDIPAVV
       ...  . |.|..||... | ..|. . ...|..| ... .         .....||..|||| | ||||..| .   ..     . .|.  .|
.......nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeav

TIMREQRMM-MIQTLDQYMLVHEAVLE
  .||||.. ..||..||. ..||.||
kllreqRpgkavqtpsqyrflyealle
0044763 (Phosphotyrosine protein) phosphatases II 11-222 1.9e-26 88.2 In-house 30-167 (178) alignment 
Range on Protein: 11-222
Range on HMM: 30-167/178.0
KYIATQGPldrtvVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSedygpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgridpn
 |.....|     .|.........  .||.||. .|  ..|| .|||.. .                                                 
lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................................................

kkeyyssaqstlliTHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDaltesIIDIPAVVTIMREQRMmMIQ
               .|..| .  .|... .  . .| ..| .  . |.||..|||| | ||.|... .   .|       .......  .||.|. ...
..............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivp

TLDQYMLVHEAV
. .|.  ..|  
npgqlrqLyefe
subfamily_egg_pd Subfamily egg 11-234 1.2e-18 61.9 In-house 84-280 (307) alignment 
Range on Protein: 11-234
Range on HMM: 84-280/307.0
KYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlrIKCSQYWPSRGSEDYG----PFTVTLQKETTSNS--FIIRELTLhyntMMGNlrskivnpt
..| .| ||  || ||||||.||.   |||||  .|    .|  |||   |.        . ..  |        | . .| |    . |.         
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl....vGgd.........

gridpnkkeyyssaQSTLLITHYQFiDWLEYGP-QPPINSLvkfnkiisNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIP--AVVTIM
              .  . . |.|  |. . .    |.. |         .  .   |.||..  |  ...... .  .. . |   |   .    |  .
..............deerflehwqg.dvnnssdvysplrvl........rklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvfl

REQRMMMIQTLDQYMLVHEAVL--EQALCGDTQIV
| .| . ...  .|..|.  ||   . . | .. .
rlrrrlsvesvllylfvyrlvlfffrdvigsakel
0051082 (Phosphotyrosine protein) phosphatases II 12-223 2.8e-28 93.8 In-house 15-150 (151) alignment 
Range on Protein: 12-223
Range on HMM: 15-150/151.0
YIATQGPLDrtvvDFWRMVWQEKACAIVMLTKLQEDLriKCSQYWPSRGsedygpftvtlqkettsnsfiireltlhyntmmgnlrskivnptgridpnk
.....|||.    ||........  .||.|....|    .| .|.|. |                                                   
lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................................

keyyssaqstLLITHYQFIDWLEYGPQPPINSLVKFNKIISNqteHKKGPIVVHCSTGGGRTGAFIGMSCSIKDaltesiIDIPAVVTIMREQRMMMIQT
          . ..|....|| ..| .  ......| ... .   .|.||..|||| | ||||..... . . .      ... ...  .|..|....|.
..........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

LDQYMLVHEAVL
 .|..... |.|
nqqflfqlfall
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 13-90 5.6e-07 24.0 In-house 63-153 (290) alignment 
Range on Protein: 13-90
Range on HMM: 63-153/290.0
IATQGPLD-------RTVVDFWRMVWQEKACAIVMLTKLQEDLRI----KCSQYWPSRGSE--DYGPFTVTLQKETTSNSFIIRELTLHYN
|.|| |.         |. .|| |. |||.  .||| . .|  .      |..| | .  |   .. .||  ..  . . ...|||.....
iltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 17-217 7.5e-11 36.0 In-house 98-279 (302) alignment 
Range on Protein: 17-217
Range on HMM: 98-279/302.0
GPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTlqkeTTSNSFIIRELTLHYNTMMGNLRSKivnptgridPNKKEY
 |   |.  .| .. | . . .| |... ||   ||..|.  .  .   .| .||.    | |    . |.|   . .. ..  |          .||. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvk....tvsvktdleeftdkksfklytveik.........nekkkk

ysSAQSTLLITHyqFIDWLEYG-PQPPINSLvkfnKIISNqTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLD
    . |. | .  |  | ..| |. . ..|    .|.    |  |  ..||||.| ||||... .   |.  ... . |.  .|. .|. |   .|. .
..kvkktvdila..fsawpdhGapkeaytal....dilkf.cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq

QYML
| . 
qliy
0038934 (Phosphotyrosine protein) phosphatases II 94-179 1.1e-08 30.5 In-house 48-135 (194) alignment 
Range on Protein: 94-179
Range on HMM: 48-135/194.0
GNLRSKIVNPTGRIDPNK-KEYYSSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGM
  |... |. .  || .. . ||.    . .  .|  . . ..|. |... | .| ...   ..  ..| ..|||  | |||| ... 
rylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
0048076 (Phosphotyrosine protein) phosphatases II 96-223 1.4e-19 65.7 In-house 36-140 (145) alignment 
Range on Protein: 96-223
Range on HMM: 36-140/145.0
LrskivnptgridPNKKEYYSsaqstLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKkGPIVVHCSTGGGRTGAFIGMSCSIKdaltESiIDIP
|             . .|...      |...|....|  .|... .. | .| ..| .  ... ||..|||| | ||||..... . ..    .. ....
l............tselelle.....rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsle

AVVTIMREQRMMMIQTLDQYMLVHEAVL
 ..  .|.||...... .|.  ..|..|
ealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 109-220 1.9e-18 62.0 In-house 42-139 (144) alignment 
Range on Protein: 109-220
Range on HMM: 42-139/144.0
PNKKEYYssaqstllITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEhKKGPIVVHCSTGGGRTGAFIGMSCSIkdalTESiIDIPAVVTIMREQRMMM
|.  | .        ...|....|  .|. . .. | .| ..| .  | ..||..|||| | ||||... .   .    ..  ...  ..  .|..|...
peflere........giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpga

IQTLDQYMLVHE
... .|.. ..|
vpnpgqlrfLle
subfamily_CDC14_pd Subfamily CDC14 110-181 1.3e-06 22.5 In-house 220-285 (328) alignment 
Range on Protein: 110-181
Range on HMM: 220-285/328.0
NKKEYYSSAQSTLLITHYQFidWLEYGPQPPINSLVKFNKIISNQtehkKGPIVVHCSTGGGRTGAFIGMSC
||| |  .      . |.    . . |  |. . . || .|. .     .| |.|||  | ||||..|.   
nkklYdakkftdaGfdhkDl..ffiDGstPsdaivkkfleiaeka....eGaiavhCkaGLGrtGtLiacyl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 114-198 5.9e-08 27.1 In-house 108-167 (255) alignment 
Range on Protein: 114-198
Range on HMM: 108-167/255.0
YYSSAQSTLLITHYQFIDWLEY-GPQPPINSLvKFNKIISNQtehKkgPIVVHCSTGGGRTGAFIgmscsikdaltesiidipavV
...  . |  ..||..  |.|  .|. . . | .  |.. .    |  ..|||||||.||. ||.                    .
tlgekkkthtvkhysykGWieknaPelareil.nilkvvrds...k..svvvhCstGiGrsaafv....................l
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 116-232 7.3e-27 89.1 In-house 167-284 (287) alignment 
Range on Protein: 116-232
Range on HMM: 167-284/287.0
SSAQSTLLITHYQFIDWLEYG-PQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQ
..|.... .. ||. .| . |  . |  .|. ... . .|  . ...|||||| . ||.. |. .  .|. . || .||.  |.  .| |.. ..|| .|
nkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

YMLVHEAVLEQALCGDTQ
|. . ..|||.  ...|.
ykfindivleyldsfety
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 116-225 5.7e-25 82.8 In-house 172-282 (290) alignment 
Range on Protein: 116-225
Range on HMM: 172-282/290.0
SSAQSTLLITHYQFIDWLEYG-PQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQ
.||...  .|.||.  | . |  . |  .|. ..... .|  . ...|||||| . ||.. |. .  .|. . ||  ||. .|.  .| |.. ..|| .|
nsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq

YMLVHEAVLEQ
| .... ||. 
yqgifqivlty
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 117-226 1.6e-12 41.7 In-house 183-289 (305) alignment 
Range on Protein: 117-226
Range on HMM: 183-289/305.0
SAQSTLLITHYQFIDWLEYGPqPPInSLVKFNkIISNqTEHKKGPIVVHCSTGGGRTGAFIGMSCSIK-DALTESIIDIPAVVTIMREQRMMMIQTLDQY
| . .. . | |. .| . |  ||   |  .. ..|      | |||||||.| ||||. . .   ..  |   .   .| .|  .|.|| . ||.  ||
sgdqkmsvrhlqwtewpdrgv.ppc.kltsle.llsa.irgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqy

MLVHEAVLEQA
. .|  .|.  
lfihrvmlnyf
subfamily_PTPRB_pd Subfamily PTPRB 118-224 4.1e-28 93.3 In-house 175-283 (293) alignment 
Range on Protein: 118-224
Range on HMM: 175-283/293.0
AQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQT--EHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQY
....  ...|.|. | ..|     ..|..| . . ...  ...|.||||||| | ||||.|| .   ...  .| ..|| ..|. .||.|....|| .||
ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqY

MLVHEAVLE
. .|..||.
ifihqcvld
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 118-228 2.1e-23 77.8 In-house 133-244 (250) alignment 
Range on Protein: 118-228
Range on HMM: 133-244/250.0
AQSTLLITHYQFIDWLEYGPQPPINSLVKFN-KIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYM
 ..  .. ...|. | . |     .. ...  |. ..| . ...|..|.||.| ||.|||| ... .. . .| ..|.  |. ..|..|. ....|.||.
kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv

LVHEAVLEQALC
 |.|..|.   .
fvyeiilkalds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 118-235 2.5e-23 77.6 In-house 173-293 (297) alignment 
Range on Protein: 118-235
Range on HMM: 173-293/297.0
AQSTLLITHYQFIDWLEYGPQP--PINSLVKFNKIISNQTEHKK-GPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQ
|... ..  |||..| .   .    ..||.|. . . .. .... ||..|||..| |||| .. .   . .|  |  .||  .|. .|..|. ..|| .|
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

YMLVHEAVLEQALCGDTQIVA
| .|..||||  |. ||.| |
ykfvyvavleallsedtriqa
subfamily_PTPN23_pd Subfamily PTPN23 118-226 2.2e-19 64.4 In-house 167-280 (288) alignment 
Range on Protein: 118-226
Range on HMM: 167-280/288.0
AQSTLLITHYQFIDWLEYG-PQPPiNSLVKFNKIISN----QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALT-ESIIDIPAVVTIMREQRMMMIQT
|. .  ..| |.  | |.| |. | ..|..| . . .    . .. | |.|||||.| ||||.|  . . ...  . . ..||. ||  .||||  |.|.
adavksvshlqltsWpelGvPasP.etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqe

LDQYMLVHEAVLEQA
 .|.  . |||||.|
keqlkfsyeavleaa
subfamily_PTPRN_pd Subfamily PTPRN 118-225 3.1e-16 53.9 In-house 183-291 (297) alignment 
Range on Protein: 118-225
Range on HMM: 183-291/297.0
AQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALT-ESIIDIPAVVTIMREQRMMMIQTLDQYM
.. |  .| . |. | | |  .  .||..| . .      .  ||||||| | ||||..| .   ..  |     ||| | .  .|.||  ...| ||. 
tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe

LVHEAVLEQ
..  || |.
faltavaee
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 118-219 4.6e-11 37.3 In-house 91-197 (199) alignment 
Range on Protein: 118-219
Range on HMM: 91-197/199.0
AQSTLLITHYQFIDWLEYGpQPPINSLVKF---NKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKD--ALTESIIDIPAVVTIMREQRMMMIQT
  ||  |.||||  | |    | .  .| |    . .|.. |  |  |..|||| | | || |. .   ..       |..|.  |   .|. |  .| .
ppstreishyqftswkekt.tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

LDQYMLVH
|..| ...
lqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 118-219 4.6e-11 37.3 In-house 90-196 (198) alignment 
Range on Protein: 118-219
Range on HMM: 90-196/198.0
AQSTLLITHYQFIDWLEYGpQPPINSLVKF---NKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKD--ALTESIIDIPAVVTIMREQRMMMIQT
  ||  |.||||  | |    | .  .| |    . .|.. |  |  |..|||| | | || |. .   ..       |..|.  |   .|. |  .| .
ppstreishyqftswkekt.tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

LDQYMLVH
|..| ...
lqhynfiy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 118-225 5.4e-11 36.7 In-house 163-268 (281) alignment 
Range on Protein: 118-225
Range on HMM: 163-268/281.0
AQSTLLITHYQFIDWLEYgpQPPINSLVKFnKIISnQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMRE-QRMMMIQTLDQY
   | ||||. . .| ..  | |  | | . ||.  .   .  | |.|||.| ||.|... .  ...   .  .. ||  .|. .|   |   .|||.||
egetrlithwlwkewpdw..qvpessevml.kilr.kirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqy

MLVHEAVLEQ
||. . .|. 
mliwkvlldf
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 119-244 4.9e-31 103.0 In-house 175-301 (305) alignment 
Range on Protein: 119-244
Range on HMM: 175-301/305.0
QSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKG-PIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYML
. .  ...||. || . |      ||... | . .. .. || |..|||| | ||||.|| ..  .  . .| ..|.  |.  .|..|| |.||||||. 
kesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvf

VHEAVLEQALCGDTQIVACDLQNTISS
.|.|. |   ||||.|.  .|.  .  
lhdaldelitcgdtsiigsnlrarvnk
subfamily_PTPRA_pd Subfamily PTPRA 120-247 6.5e-26 86.0 In-house 189-316 (330) alignment 
Range on Protein: 120-247
Range on HMM: 189-316/330.0
STLLITHYQFIDWLEYG-PQPPInSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLV
.. |.. . |  | . | |  ||  ..|. | . .. . . ||||||||.| ||||.|| ..  ..   .| ..|.  .|  .| ||  |.||. || ..
ksrlvrqfhftswPdvGvPfepi.GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

HEAVLEQALCGDTQIVACDLQNTISSLSS
....||  | |||.. .  |.. . .| .
ykvlleyylygdteldvsslekhlqklyn
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 120-248 1.6e-24 81.6 In-house 176-310 (325) alignment 
Range on Protein: 120-248
Range on HMM: 176-310/325.0
STLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH------KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLD
 |. .  .|.  | . | |    .|. . ... .  |         .||.||||.| ||||.|| . . ..  ..|| .||  .|  .|..|  |..| |
etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

QYMLVHEAVLEQALCGDTQIVACDLQNTISSLSSS
||.|..||. |  ..|.|..  . ..  .|||   
qyiliyealveaymsgntdvpvssfeaklsslqer
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 120-224 1.1e-23 78.7 In-house 168-274 (281) alignment 
Range on Protein: 120-224
Range on HMM: 168-274/281.0
STLLITHYQFIDWLEYGPQPPINSLVKFNKIIS-NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMREQRMMMIQTLDQYML
 |  ... ... | . |     . |..| | .   .....| |.|.|||.| ||||..|..   .| . .| . .|. |||. .|..|..|.||. ||  
etreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyef

VHEAVLE
|. |||.
vykavld
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 120-223 5.2e-08 27.4 In-house 156-256 (290) alignment 
Range on Protein: 120-223
Range on HMM: 156-256/290.0
STLLITHYQFIDWLEYGPQPPINSLVKFNKIISnqteHKKGPIVVHCSTGGGRTGAFIGMSCSIKDAL-TESIIDIPAVVTIMREQRMMMIQTLDQYMLV
  . .||... .| .   |.   .|..  . .      .| |..|||  |  |  |.  .  .      |.. . . .|.  .|.|| ..|..  ..  |
eeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv

HEAVL
  ...
dagiv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 121-257 5.9e-33 109.3 In-house 177-315 (319) alignment 
Range on Protein: 121-257
Range on HMM: 177-315/319.0
TLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVH
|  ..|.|. .| . .      ||... | | . .|. ..|||||||| | ||||.|| ..  .     |...|.  .|  .| || .|.|. .|| ...
tRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiy

EAVLEQALCGDTQIVACDLQNTISSLSSSDNAS-VTGFE
||.|| . .|||.|   ||.. . .|.. .  .  ||.|
ealleaveagdteievqdlrdrlkqlaekvadtgetgle
subfamily_PTPN9_pd Subfamily PTPN9 121-227 4.5e-21 70.1 In-house 172-291 (297) alignment 
Range on Protein: 121-227
Range on HMM: 172-291/297.0
TLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQ------------TEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMM
.  .||.||. | .||     .||... . . ..            . | .. |||||||.| ||||.|| .  ...   ... .|.  .|  .|.||  
srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqraf

MIQTLDQYMLVHEAVLEQAL
.||| .||.. . |||| ||
siqtpeqyefcylavleyal
subfamily_PTPN13_pd Subfamily PTPN13 121-224 7.7e-21 69.6 In-house 165-267 (273) alignment 
Range on Protein: 121-224
Range on HMM: 165-267/273.0
TLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEhKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHE
.  ..| .|..| ..|     ..|..| . . .  . ..||||||||.| ||.|..| .   .     .  .|.  .|  .||||  ..|| |||..|..
srevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk

AVLE
|.||
aile
subfamily_PTPN3_pd Subfamily PTPN3 122-224 1.8e-22 74.6 In-house 171-273 (280) alignment 
Range on Protein: 122-224
Range on HMM: 171-273/280.0
LLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEA
  |.. |...| . |     .....| . . .. . |. |.|||||.| |||| .| .  ..    ..  . ....|  ||.||.|..|| .|| .| ||
rkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea

VLE
.|.
ilk
subfamily_PTPN14_pd Subfamily PTPN14 122-223 4.2e-19 63.6 In-house 183-293 (300) alignment 
Range on Protein: 122-223
Range on HMM: 183-293/300.0
LLITHYQFIDWLEYGPQPPINSLVKFNKII----SNQT-----EHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTL
  . | |..|| . |  . ... ... . .     . .     ...| |..|||| |.||||  |     |.   ..  |||. |....|||||...|||
rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl

DQYMLVHEAVL
 ||  |.....
aqYkfvYkvli
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 122-223 4.3e-14 47.0 In-house 168-274 (287) alignment 
Range on Protein: 122-223
Range on HMM: 168-274/287.0
LLITHYQFIDWLEYGPQPPINSLVKFNKII-----SNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYM
 ..  .....| . .  |   .|..|   .      ..   . ||.|||...| ||.| .. .   ..  .    .|. |||  .||.|  ..|.  |. 
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlr

LVHEAVL
|. ||. 
llyealv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 122-225 1.6e-09 32.2 In-house 167-269 (285) alignment 
Range on Protein: 122-225
Range on HMM: 167-269/285.0
LLITHYQFIDWLEYGPQPPINSLVKFNKIISnQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEA
| . | |   | .         .... | .  . . |. ||.||||.| ||| .|.|.  .    . .  |..  .|  ||  |.  .|.  |.....  
lymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvv

VLEQ
..| 
lmey
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 123-260 2e-30 100.9 In-house 176-315 (318) alignment 
Range on Protein: 123-260
Range on HMM: 176-315/318.0
LITHYQFIDWLEYGPQPPINSLVKFNKIIS-NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEA
 .  |.. .| . |      ||... . .|  |.....||||||||.| |||| || ..  .. .  |...|.  .|. .|||| .|.|| ||| .....
qvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydv

VLEQALCGDTQIVACDLQNTISSLSSSDNA-SVTGFEAQF
.||   .|||.. | ||.. |  |  .|.    | ..|.|
llealasgdtevdasdlrsrirelreqdpesgttemdaef
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 123-268 2.5e-26 86.9 In-house 173-319 (515) alignment 
Range on Protein: 123-268
Range on HMM: 173-319/515.0
LITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
 .| ..| .| . | ..  .||.|. | .  .... . |...|||.| |||| .| .   . .| |  ..|.  .||..|..|. ..|| .|| ....||
tvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

LEQALCGDTQIVACDLQNTISSLSSS-DNASVTGFEAQFNVLEQVSV
||. |  .| |    . . .  | || |    . .  .|. |. .  
ledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcp
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 123-248 1.2e-22 75.7 In-house 186-313 (319) alignment 
Range on Protein: 123-248
Range on HMM: 186-313/319.0
LITHYQFIDWLEYG-PQPPINSLVKFNKI-ISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHE
 || . |  | ..| |. |.. .   .|.   .. |... .||||||.| ||||..| . . ..    |. .|.  .|  .|.||  ..| | ||.... 
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AVLEQALCGDTQIVACDLQNTISSLSSS
|.||. | | ....  |.   .  ||. 
alleehlfghsdvampdfpayleelsnk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 123-247 2.1e-22 75.0 In-house 150-276 (284) alignment 
Range on Protein: 123-247
Range on HMM: 150-276/284.0
LITHYQFIDWLEYG-PQPPINSLVKFNKI-ISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHE
 |. . |  | ..| |. |.. .   .|.   .. |... .||||||.| ||||..| . . ..    |. .|.  .|  .|.||  ..| | ||.... 
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AVLEQALCGDTQIVACDLQNTISSLSS
|.||. | | ....  |.   .  ||.
alleehlfghsdvalpdfpayleelsn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 123-244 1.8e-21 71.0 In-house 90-212 (440) alignment 
Range on Protein: 123-244
Range on HMM: 90-212/440.0
LITHYQFIDWLEYGPQPPINSLVKFN-KIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEA
 . .|..  | . |       ..|.   .  .| .  .||..||||.| ||||  | . . ...|     ||| ...  ||..|  |.|| .|| .||||
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

VLEQALCGDTQIVACDLQNTISS
|||  ||||| |.  |. . .  
vlegllcgdtliledditerveq
subfamily_PTPN12_pd Subfamily PTPN12 123-224 2.2e-20 67.7 In-house 171-275 (290) alignment 
Range on Protein: 123-224
Range on HMM: 171-275/290.0
LITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESI---IDIPAVVTIMREQRMMMIQTLDQYMLVH
 .. ... .| . |    ..||... . . .  |... |.||||| | ||||. | .    .   .| |   .|.  .|. .|.||  ..|| .|| ||.
kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvy

EAVLE
.||.|
kavae
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 123-224 4.3e-17 57.0 In-house 153-262 (270) alignment 
Range on Protein: 123-224
Range on HMM: 153-262/270.0
LITHYQFIDWLEYGPQPPIN------SLVKFNKII-SNQTEHKKG-PIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQ
 ..|... .| . |  .  .      .|.|  . .   ..|..|. |..|||| | |||| .| .   ..   ... .|. |... .|..|| ..|. .|
rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeq

YMLVHEAVLE
| ....||.|
yeflykavve
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 123-226 6.4e-12 40.1 In-house 172-271 (288) alignment 
Range on Protein: 123-226
Range on HMM: 172-271/288.0
LITHYQFIDWLEYGPQPPINSLVKFNKIIsnqtEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
.. .  . .| . |      | ... ...    .  . |||||.|.| ||||..| .   .. .  .  . |. ... .||.|.  |||  ||. ||  |
ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

LEQA
||. 
leel
PTPc_DSPc_SM00012 124-224 1.1e-23 78.8 In-house 2-105 (105) alignment 
Range on Protein: 124-224
Range on HMM: 2-105/105.0
ITHYQFIDWLEYG-PQPPiNSLVKFNKIISNQTEHKK--GPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMREQRMMMIQTLDQYMLVH
..||.. .| . | |... .|.... . . .......  .|.|||||.| |||| |. ... ...  .| . .||  .|  .|.||. |.||..||. ..
vkhyhytgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAVLE
.|.||
ralle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 124-226 4e-17 57.1 In-house 158-259 (267) alignment 
Range on Protein: 124-226
Range on HMM: 158-259/267.0
ITHYQFIDWLEYGP-QPPINSLvkFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
.| | .  |      .| .. |  |  .  || |    |.||.|| | ||.|.|. .   .. | ||.. ||   .  .|.||. ...|...|. .|| .
vtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell

LEQA
 | |
aeya
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 124-224 1.3e-15 52.3 In-house 138-238 (239) alignment 
Range on Protein: 124-224
Range on HMM: 138-238/239.0
ITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
. .|.|  | . |      ... . . |....     | |.|||.| ||||||. . . ...|  .  .||   |  .||.|  |.|| .||...| |||
vyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

E
|
e
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 124-224 2e-15 51.6 In-house 139-239 (239) alignment 
Range on Protein: 124-224
Range on HMM: 139-239/239.0
ITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
. .|.|  | . |      ... . . |....     | |.|||.| ||||||. . . ...|  .  .||   |  .||.|  |.|| .||...| |||
vyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

E
|
e
subfamily_PTPDC1_pd Subfamily PTPDC1 124-220 1.1e-08 29.7 In-house 83-170 (182) alignment 
Range on Protein: 124-220
Range on HMM: 83-170/182.0
ITHYQFiDWLEYGPqPPINSLVKFNKIISNQTEHKkgPIVVHCSTGGGRTGAFIGMSCSIKDALTESiidipAVVTIMREQRMMMIQTLDQYMLVHE
|..|.|  | .||  .......   |...   ...   . |||  | ||||  |      .. || .       ....|..|   ||| .|  ||.|
iyvynf.gwkDygv.asleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 124-225 1.9e-08 28.4 In-house 178-275 (312) alignment 
Range on Protein: 124-225
Range on HMM: 178-275/312.0
ITHYQFIDWLEYGPQppiNSLVKFNKIISNQTEHKKgPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
. |||.  | ..|     .|     ...|     || |.. |||.| ||||... .   |         ..  .  ..| .|   .... ||. .  .||
lnhyqwaswpdhgmp...dscdtalrllsavkkdkk.pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvl

EQ
| 
ef
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 126-260 8.3e-24 79.1 In-house 179-314 (315) alignment 
Range on Protein: 126-260
Range on HMM: 179-314/315.0
HYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
 ...  | . |      .|... . .    . . |.|||||| | ||||.|| ... .. | .| .||.  ..| .|..|. |.|...|| ....|.|| 
qlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

ALCGDTQIVA-CDLQNTISSLSSSDNASVTGFEAQF
 .|||| |     ||.  | |. | ..  | .. ||
fvcgdtsiaqdlylqrydsllapspdtgstllqeqf
0048567 (Phosphotyrosine protein) phosphatases II 133-179 2.9e-06 21.7 In-house 46-97 (157) alignment 
Range on Protein: 133-179
Range on HMM: 46-97/157.0
LEYGpQPPINSLVKFNKIISNQT---EHKKGPIVVHCSTGG---GRTGAFIGM
 ..|  .... |..|.... .     |.....|.|||..|    |||. .|| 
fdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_DSP23_pd Subfamily DSP23 134-220 3.1e-06 21.9 In-house 61-140 (148) alignment 
Range on Protein: 134-220
Range on HMM: 61-140/148.0
EYGPqPPINSLVKFNKIISnQTEHKKGPIVVHCSTGGGRTGAFIgmSCSIKDaltESIIDIPAVVTIMREQRMMMIQTLDQYMLVHE
.| | | .. .|.| ...  ..|.|.  . |||  | ||||...  .| .     |  .     .. .|..|   ..|..|  ||..
dyhp.paleqvvefvrvve.eaeekneavsvhcllgrgrtgtml..acylvk...erklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 148-225 3.1e-14 47.5 In-house 216-294 (297) alignment 
Range on Protein: 148-225
Range on HMM: 216-294/297.0
NKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
 .. | ..|. .. ...||||.| ||.|  .     ..    . | |. |...|.|||| ...|||.|. |...|||..
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_CG42327_pd Subfamily CG42327 151-222 6.7e-15 49.5 In-house 237-311 (319) alignment 
Range on Protein: 151-222
Range on HMM: 237-311/319.0
ISN--QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
||.   |....||.||||| | ||||  |    .|.   .    .||| .|  .|..|   ..| .|| ...  .
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 152-222 6.5e-08 26.3 In-house 211-281 (302) alignment 
Range on Protein: 152-222
Range on HMM: 211-281/302.0
SNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
 ..... . ..|.    | || |||. .  ...   ...   |  .|. .|.||  ....|.||. .. |.
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 155-224 2.8e-11 37.6 In-house 212-281 (290) alignment 
Range on Protein: 155-224
Range on HMM: 212-281/290.0
TEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
  .  ||.|||||.| ||||.|. .  ...  |    .|.  .|  .|. |.  .|   ||... |..|.
lrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 157-224 1.7e-08 28.4 In-house 221-288 (310) alignment 
Range on Protein: 157-224
Range on HMM: 221-288/310.0
HKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
 ..|| |||||.| .|... . .  .|. .     .|.  |.| .. .|.. |||  ||....   . 
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 162-225 2e-13 44.5 In-house 1-64 (69) alignment 
Range on Protein: 162-225
Range on HMM: 1-64/69.0
IVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
.|||||.| ||||.|| .   .    .| ..||   |  ||  | ||.    .|...|.|. | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 163-225 1.2e-13 45.2 In-house 1-63 (69) alignment 
Range on Protein: 163-225
Range on HMM: 1-63/69.0
VVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
|||||.| ||||.|| .   .    .| ..||   |  ||  | ||.   ..||..|.|. | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 215-423 1.9e-18 61.0 In-house 28-237 (244) alignment 
Range on Protein: 215-423
Range on HMM: 28-237/244.0
YMLVHEAVLEQALCGDTQIVACDLQNTISSLSSSDNASVTGFEAQFNVLEQVSVPPQDAVCDVA--RQHPRKNRYQEILPTDQWRVHLKSES--PDYINA
 .|  .|||    . .  |    ...|   |||| . .    .|..    |  . |. .|   |   .   |||    || |  || |   |    ||||
eflqtnavlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyina

VFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeacaqYWPKEGTIEFGEFTISV--REEWGHQSFSRKLLLIRNNKNNMLRRL
 |.        .|..| || .|  |||||...| .  .|.|  . | .|     |||    .|. |  |.|   .    .      | |  . |.  . |
sfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqal

AHFQVDGWSNDDITS
. ||.  |  |  | 
tmfqisnwpsdgttp
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 229-519 1.1e-72 239.8 In-house 1-297 (298) alignment 
Range on Protein: 229-519
Range on HMM: 1-297/298.0
GDTQIVACDLQNTISSLSSSDN-ASVTGFEAQFNVLEQVSVPPQDAVCDVARQ--HPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKG
|.|.| | ||..... |.. ..  ..||....|. |..||   ...  .|||.    .||||..|.. |. || |..    |  |||||.|. .||. . 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDI
||..| || ||  |||.|. ...|.||||| .. | ..  . .|||.||. ..||.|.|....  .  .  . | . ..|..  |.. ....  |.. ..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

TScNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
.. |. .... .. |.. |... |.|....||. .|||  |.|  . ....| ..||||||.|| .|.. ||||| . ||. |...   ... |.. .
pe.natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPN6_pd Subfamily PTPN6 231-513 1.7e-44 147.0 In-house 2-298 (306) alignment 
Range on Protein: 231-513
Range on HMM: 2-298/306.0
TQIVACDLQNTISSLSSS-DNASVTGFEAQFNVLEQVSVPPQDAVCDVAR-QHPRKNRYQEILPTDQWRVHLK---SESPDYINAVFIP--SYKNDKGFI
|...| .... .| |. . .. . .||| .|. |.|  .  .    . |. .  .||||. ||| |. || ||       ||||| .|   . ..|| .|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyi

IAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGT-IEFGEFTISVREEWGHQSF-SRKLLLIRNNKNNMLRRLAHFQVDGWSNDDI
 .|  |..|  |||.|... . . |||.   .|  .| ||.|||.| .  |.|. ...  .|  ....  |.|.. ...|..  |.. ...   | . ..
atqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgv

TScNEGAIINTMNLVKTLQRKSP---NSPILMHCSNMIGRSAVFCAAMATVDQMKSS---SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
 . . ||... .. |.. |...    . ||..|||. |||   |    . .......     .|. ..|| .|    | || . |||....  ..|..
pk.dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0051299 (Phosphotyrosine protein) phosphatases II 238-512 2.9e-68 225.8 In-house 10-286 (288) alignment 
Range on Protein: 238-512
Range on HMM: 10-286/288.0
LQNTISSLSssdNASVTGFEAQFNVLEQVSVPpQDAVCDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETR
| ...  |      ..||....|. | .. ..  .  . .  ..  ||||. ||| |..||.|..    |. ||||| .|. |.... ||..| || .| 
llklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

RDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNN----KNNMLRRLAHFQVDGWSNDDITScNEGAI
 |||.|... ....|||| ...| . | |||||| .|....|..|.  ..|  ....    | ..|.    ...  |.  ||.. .| .... . .  ..
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd.spell

INTMNLVKTLQRkSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
.. ..||.. .. |...|.. |||. .||...|.|.   ..|..   .|||...|| .|   ||.||.  ||.... ... |.
ldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 239-518 3.2e-68 225.7 In-house 25-305 (308) alignment 
Range on Protein: 239-518
Range on HMM: 25-305/308.0
QNTISSLSS--SDNASVTGFEAQFNVLEQVSVpPQDAVCDVARQHPRKNRYQEILPTDQWRVHLkSESPDYINAVFIPSY--KNDKGFIIAQSPLRETRR
. .. .|     .  . ...|..|. | .| . . .  .    ..  ||||  ||| |. ||.| .|. ||||| ... |  |... ||..|.|| .|  
klsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntve

DFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE---GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITsCNEGAIIN
|||.|... ....||||  ..| . | |||||| |   |..|.| ||. ...|  .... .  | ..|....  |.. ||.  .| ....   .  ....
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvP.pspeilld

TMNLVKTLQrksPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
 ..||.. .   |..||. |||. .||...|.|.   ..|..    ||||..|| .|   ||.||.. ||. .. ... |..|. | 
flelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 243-518 1.3e-61 203.4 In-house 11-289 (305) alignment 
Range on Protein: 243-518
Range on HMM: 11-289/305.0
SSLSSSDNASVTGFEAQFNVLEQVsVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESP--DYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMI
. . ..   | .|.|||.. | .    . |  .. |...  ... . .|..|. ..  |.. .  ||||| .. .||. | .|.||.||..| .|||..|
ayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrli

FDREITTIVMLSPIMEGEEEACAQYWPKEGTI--EFGEFTISVREEWGHQSF-SRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVK
..  ..|||||. ..||... | ||||.. |   |||||.. ...|   . .  ||| .  .....  | . ..|.  | .. .     ..... .. |.
veekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq.fatsllslikrvq

TLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
  |.|. . |.| |||. .||. ||.|    ....|   |||||. .|..| . ...||.. ||  .|   . ... . ||
kdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 243-507 5.5e-61 201.1 In-house 10-274 (288) alignment 
Range on Protein: 243-507
Range on HMM: 10-274/288.0
SSLSSSDNASVTGFEAQFNVLEQVSVPPQDAVCDVARQHpRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWK
.     .  . |||. ..|.| ..    .. .   |. . .||||..||| |. ||.||     .. ||||| .| ..|..| .| .|.|| .|  |||.
akvakksarnrtgfseeynsLaalektksvtagrlavna.kknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MIFDREITTIVMLSPIMEGEEEACAQYWPKEGT-IEFGEFTISVREEWGHQSFSRKLLLIRnnKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVK
........|||||. ..||... | .|||....  ..|..|. ..|.   ..|  . ||.   |..  ... ..|  .|.....   ..  ... .. ||
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPe.skapllellrqvk

TLQRKSpNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
. . .    ||..|||. .||. .| |. | .|..... ..||. ||...| . .  ||.. ||  |.  
vanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 246-507 3.3e-50 165.8 In-house 16-274 (315) alignment 
Range on Protein: 246-507
Range on HMM: 16-274/315.0
SSSDNASVTGFEAQFNVLEQVSVPPQDAVCDVARQhpRKNRYQEILPTDQWRVHL----KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIF
.    ..  ||. ... .    . | |   ..  .  .|||| .|...|. ||.|    . .  ||.|| ||. |.  . .| ||.|. .. .|||...|
aqkkastkngfkqdyesipggqlhpldvakkienk..qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvf

DREITTIVMLSPIMEGEEEACAQYWPKEgTIEFGEFTISVREEWGHQSFSRKLLliRNNKNNMLRRLAHFQVDGWSNDDITSCnegaIINTMNLVKTLQR
. .|..||||. ..|||.. . .||| .  . .|..|.. ..|  .. .. . |      .. .| .  ...  | . ...       |. |||..| ..
eedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpky....tiplmnlirtvkq

KSPN--SPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
   |  ..|..|||. .||.  |..  | .||..   ..||.. ....| |  ..||   ||..|.  
hhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_PTPRB_pd Subfamily PTPRB 247-507 5.6e-56 184.7 In-house 18-280 (293) alignment 
Range on Protein: 247-507
Range on HMM: 18-280/293.0
SSDNASVTGFEAQFNVLEQVSVPpQDAVCDVARQHPRKNRYQEILPTDQWRVHL----KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFD
.  . | ..|  ... |..|    |  ... . .   ||||..||| |. ||.|    .... ||||| .|| |.  . || .| || ||. |||.|...
kmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwe

REITTIVMLSPIMEGEEEACAQYWPKE-GTIEFGEFTISVREEWGHQSFSRKLLLIRNnkNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKT-LQ
.. ..||||  ..|.  . | .|||..  .. .|. .... .|   . .  . |.|..  ... |.. ...   |.. .. .  . .... .. |.. ..
kkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektk.tlldfvrtvreaie

RKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
... ..||..|||  .||. .| |    ....... .||.| .| ..| .    ||.. || .||. 
ktaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqc
subfamily_PTPN23_pd Subfamily PTPN23 247-506 8.8e-50 164.1 In-house 8-274 (288) alignment 
Range on Protein: 247-506
Range on HMM: 8-274/288.0
SSDNASVTGFEAQFNVLEQVS-VPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKND-KGFIIAQSPLRETRRDFWKMIFDRE
 .    .|.....|. |||      ..  . .|. .. |||...||| |. ||.|...  ||||| |. .       ||..|.||..|  |||.|.... 
rkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

ITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKT---L
  .||||    | ... ...|||..   | .||.........   . .... | .. ....  . . | |.  |..  . .  |  ... .. |..    
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPe.tllqfldevesayea

QRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS-SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
...  . |...|||  .||. ||.  .| | ...    ..|. | |. .| .    ||.| |.|.   
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsye
0043336 (Phosphotyrosine protein) phosphatases II 248-511 1.7e-62 206.8 In-house 14-276 (278) alignment 
Range on Protein: 248-511
Range on HMM: 14-276/278.0
SDNASVTGFEAQFNVLEQVSVppQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDR
   .. |.....|  | .. .   .  .    ..  ||||  ||| |. ||.|....     ||||| ... |.  ..||..| || ||  |||.|... 
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

EITTIVMLSPIMEGEEEACAQYWPkEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRkS
 .|||||| . .| . . |||||| .|....|.||. ...|  .. . .  | . |....  |   |..  ||  ... . .   ... .. |.. .. .
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreale.d

PNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
.|.|.| |||. .||...|.|.   ..|...   ||....|| .|   |||||.  ||.... ... |
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Ptp69D_pd Subfamily Ptp69D 248-512 2e-57 189.7 In-house 16-286 (307) alignment 
Range on Protein: 248-512
Range on HMM: 16-286/307.0
SDNASVTGFEAQFNVLEQVsVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLK----SESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDR
... .  |..  .. ||.    .....         ||||..| . |. || ||    .|. ||||| || .||. | ||.|| |. .|  |||.|| . 
rkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

EITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNM-----LRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKT
|.|.||||| . | ... ||.|||.| ....|.  . . .|  |. . .. | . ..|..       |..  ..  ||  | .      .... .. |. 
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvre

LQRKSpNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
|.... .|||..|||.  |||..| |    ..|.|    ||.|.|||..| . .  ||.  ||. ..   . | 
lykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 248-506 4.8e-48 159.1 In-house 28-285 (319) alignment 
Range on Protein: 248-506
Range on HMM: 28-285/319.0
SDNASVTGFEAQFNVLEQVSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDR
  .  .| .|..|. . ...|.  |       |   |||. .||. |. .| |.     |  ||||| |.  |.. . .| || || .|  |||.||.. 
dfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

EITTIVMLSpimegeEEACAQYWPKEGTIEFGEFTISVREEWGHQSFS-RKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRK
...|||.|.      .. |.||||... |. ..| ..|      . .  |.. | .. |..  |..  |   || .          ..  .. |. |..|
ncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp.sdlmrlvkkvrhltsk

-SPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
   . .|..|||  .||. |. .  . .|.||  . |||...|...| . .  ||.  |||.|..
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 248-506 1.7e-29 97.4 In-house 5-263 (281) alignment 
Range on Protein: 248-506
Range on HMM: 5-263/281.0
SDNASVTGFEAQFNVLEqvSVPPQDaVCDVARQ--HPRKNRYQEILPTDQWRVHLKS-----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMI
|.. ..  |. .|  |     || | .| |  |    .|||| .|   |  ||.||      .| ||| | .| |    .|.|..| | .||| |||.||
sqkmtlddfkqefsnlp..gdppsd.lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmi

FDREITTIVMLSPIMEGEEEACAQYWPKEG--TIEFGEFTISVREEWGHQSFSRKLLLIRnnKNNMLRRLAHFQVDGWSNDDITSCNEgaiInTMNLVKT
.. . |.||||  ..| . | ||.|.|..    ..| ....|  .    .|.    | .    .   | ..|.    | . ..    |   .  ..... 
wqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpesse...v.mlkilrk

LQRKSpnSPILMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLP-GAVQNKGQYKMIHT
.. .|  .| ..|||  .|||  . |   ... ..|  .. |. | |  .||     .||   || .|  
irars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 249-519 3.7e-139 457.4 In-house 1-283 (283) alignment 
Range on Protein: 249-519
Range on HMM: 1-283/283.0
DNASVTGFEAQFNVLEQVSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIP---SYKNDKGFIIAQSPLRETRRDFWKMIFDREI
||..|........||...|||..||....|....||||.|||.|.|||||.|||||.|||||||||   |||.||..|||||||..|..|||||.||..|
dnlrvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

TTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNN---KNNMLrrLAHFQVDGWsnddiTSCNEGAIINTM---NLVKTL
|.||||....|.....|.|||||.|....||||...|.|....||..|.||.|.|   |...|  |||.||..|     ....|.||||..   |.|..|
taivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvidW.....leygeqaiinslvkfnkvisl

QRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA----------AAYVNLFSTSA
|..|...||..|||..|||.|||.||.|.|......||||||..||.||.....|||...|||..|.|.          .|.|.|.||.|
qteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqstia
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 249-513 1.3e-46 154.0 In-house 10-277 (281) alignment 
Range on Protein: 249-513
Range on HMM: 10-277/281.0
DNASVTGFEAQFNVLEQVSVPpQDAVCDVARQHPRKNRYQEILPTDQWRVHL----KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDRE
.. . .||  ... |... |  . |.   | .   ||||. |   |. ||..    .... ||||| |.|.||..|..|..|.|. ..  .||.|.....
sqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

ITTIVMLSPIMEGEEEACAQYWPKEG-TIEFGEFTISVREEWGHQSFSRKLLLIrNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKS
...|||.   .|..   | .||| .  ....|..|..  .|  .... .. . . .....  |......   | .  . . .  ....  . |. |..|.
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPa.ttkellefrkevlkltekk

PNSPILMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
 . |...|||  .||. .. |    |...... . .|| ..|...| .    ||   ||. ..     ...
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 250-521 1.3e-78 258.9 In-house 16-287 (287) alignment 
Range on Protein: 250-521
Range on HMM: 16-287/287.0
NASVTGFEAQFNVLEQVSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIV
. . .||. || |||||.  ...   ..| |   |||...||. |. || || | ||||||||| .||..| ||||.||. .| |.|||.| ||..|.||
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaiv

MLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREE-WGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKTLQRKSPNSPI
||.  .| .||.| ||||.| .. .||..|.. .|   ..   ||| ....||..  ...  .|.  | .    .. . .|.  ..     |||. |..|
mlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq.tillvieemyktqrkrgntsi

LMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSANF
..|||. .||||.||||  |... |   |.|||| .|..|.  ||.||   |||.|  .  .|.. |.| ..|
vvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0040438 (Phosphotyrosine protein) phosphatases II 250-515 3.2e-65 215.8 In-house 14-279 (317) alignment 
Range on Protein: 250-515
Range on HMM: 14-279/317.0
NASVTGFEAQFNVLEQVSVPpqDAVCDVARQHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREI
. ..|... .|. | .....  .  .    ... ||||  ||| |. ||.|....     ||||| ... ..  . ||..|.|| .|  |||.|...  .
ksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

TTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRkSPN
|.|||| . .| . | |||||| ..|...|.||. ...|  ....    | . .....  |.. ||.  ||  ... . .   ... ...|.. .. .|.
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp.spdllldfleavreale.dpg

SPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLF
.|.| |||. .||...|.||   ..|..    |||...|| .|   |||||. .||. ...... |.. .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0047943 (Phosphotyrosine protein) phosphatases II 250-511 8.4e-65 214.3 In-house 8-271 (273) alignment 
Range on Protein: 250-511
Range on HMM: 8-271/273.0
NASVTGFEAQFNVLEQVSVpPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIV
  ..|.....|. | .. . . .  . .  ..  ||||. ||| |. ||.|.... ||||| ... |.  . ||..| || .|  |||.|...  ...||
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLSPIMEGEEEACAQYWPKEG---TIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKS-PN
|| ...| . | |||||| ||   ....|.||. ...|  ....    | ..|....  |   ||.. || .... . .   ... ..||.. ....  |
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp.slesllefielvrkalealpsn

SPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
.|.. |||. .||...|.|.   .||..    |||...|| .|   ||.||.  ||.... ... |
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPRG_pd Subfamily PTPRG 250-506 3.7e-52 172.3 In-house 15-281 (563) alignment 
Range on Protein: 250-506
Range on HMM: 15-281/563.0
NASVTGFEAQFNVLEQVSV-PPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESP-----DYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDR
  . .||...|. |.. ..    ||    ...  ||||| .|.. |. ||.|.. .      ||||| .|  |.  | ||..| ||..|  |||.||...
adgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

EITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRN-----NKN-NMLRRLAHFQVDGWSNDDITSCNegaiINTMNLVK
. ..|||.. . | . . | .||||......|....   ||  . . . . | |.|     .|. .  ..  ...   | . .  . .    .  .. ||
nvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs....lpvLifvk

TLQRKSP--NSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
  ..  .    ||..|||. .||. ....  . . |... ..|.||...| .| . .  ||.. ||  .| 
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 251-517 2.8e-73 241.3 In-house 17-288 (290) alignment 
Range on Protein: 251-517
Range on HMM: 17-288/290.0
ASVTGFEAQFNVLEQvSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLK--SESPD----YINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDRE
   .||..||..|.. .  .. .  ... .  ..||...|...|. |. |.  |. .|    ||||..|  ||..| .|..|.|. .| .||||.| ...
kgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

ITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQS-FSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDiTSCNEGAIINTMNLVKTLQRKS
.| ||||  |.| ... | ||||...| ..|||.| . .|  ...   ||| .  .|...  . . ..|.  | ...    |. .|. ... .   |||.
vtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkr

PNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFST
 | .|..|||. .|||||||||. |....|.  |.|||| .|..|.  || || . ||..|...   |.. |.|
gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
0045450 (Phosphotyrosine protein) phosphatases II 251-511 4.4e-61 202.6 In-house 24-303 (307) alignment 
Range on Protein: 251-511
Range on HMM: 24-303/307.0
ASVTGFEAQFNVLEQVSVP-PQDAVCDVARQHPRKNRYQEILPTDQWRVHLKS-----ESPDYINAVFI--------PSYKNDKGFIIAQSPLRETRRDF
 ..||....|. | .| |. . .  .    ..  ||||..||| |. ||.|.|     |. ||||| ..        ..|.... ||..|.|| ||  ||
dfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI-EFGEFTISVREEWGHQSFSRKLLLIRNN-KNNMLRRLAHFQVDGWSNDDITScNEGAIINTMN
|.|...  .|.||||.. .| . | |||||| ||.  ..|.||. ...|  .... .  | . .. .... |.. ||.  || .... . .   ... ..
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp.sfeelldfie

LVKTLQRKS-PNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSV---VDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
.|.. .... ...|.| |||  .||...|.||    .|...  .   ||....|| .|   |||||| .||. .. ... .
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 252-515 4.3e-61 202.3 In-house 30-292 (297) alignment 
Range on Protein: 252-515
Range on HMM: 30-292/297.0
SVTGFEAQFNVLEQVSVPpqdAVCDVARQHPRKNRYQEILPTDQWRVHLKSES-----PDYINAVFIPSYKN-DKGFIIAQSPLRETRRDFWKMIFDREI
| |.....|  | .. ..    ..    ..  ||||..||| |. ||.||.|       ||||| ... |.  .. ||..| || ||  |||.|...  .
sktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

TTIVMLSPIMEGEEeACAQYWPKEGTiEFGEFTISVREEWGHQSFSRKLLLIRNnkNNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKS-P
|.|||| . .| .   |||||| ||. ..|.||. ....  .. . .  | ..|  |.  | . |||. ||  |. .  .   ... ..||.. .... .
tvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslellleflelvrealaelpk

NSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLF
. |.| |||. .||...|.||   ..|...   |||...|| .|   |||||. .||. .. ... ... .
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 252-520 1.8e-46 153.2 In-house 13-301 (301) alignment 
Range on Protein: 252-520
Range on HMM: 13-301/301.0
SVTGFEAQFNVLEQVSvpPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSE------SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREI
  ..||.|.. |....  .. ..  .  .. . ||...| . |. |. || .      . .|||| .| .|.. | ||.||.|...| .|||..|..   
hsnkfeeqykelkege..dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVREEWGHQSFSRKLLL--IRNNKNN-------------MLRRLAHFQVDGWSNDDITScNEGA
..|||.    || .. | ||||.  . . |||.||. . .|  . .|  . |   |..  ||               . .  .||  | .| .   .   
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr.eprt

IINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSAN
... .. |   |.|   .|.. |||. ..|| |.|.   ...| |.  |||||| .| .| . ||||.   || .|.     |..| || ||
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
0036941 (Phosphotyrosine protein) phosphatases II 253-515 2.4e-66 219.4 In-house 12-280 (297) alignment 
Range on Protein: 253-515
Range on HMM: 12-280/297.0
VTGFEAQFNVLEQVSVpPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLS
 .... .|  | .. . . .  .    ..  ||||  ||| |. ||.|..|. ||||| ... |. .. ||..| || .|  |||.|...  .|.||||.
lalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

PIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWG--HQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKS-PNSP
. .| . | |||||| |  .....|.||. ....    .... .  | . ...|.  |.. ||.. ||  ... . .   ... ..||.. .... ...|
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.spaslldfielvrkvlkllpsggp

ILMHCSNMIGRSAVFCAAMATVDQMK---SSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLF
.| |||. .|||..|.||   ..|..       ||....|| .|   |||||. .||. .. . . ... .
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 253-518 5.3e-60 198.1 In-house 22-289 (319) alignment 
Range on Protein: 253-518
Range on HMM: 22-289/319.0
VTGFEAQFNVLEQVSVPpQDAVCDvARQHPRKNRYQEILPTDQWRVHLK----SESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTI
 |..| .|. |.. .   .   ..   .  .|||||.||. |. || |.    .|. ||||| || .|.. . || .|.|| .|  |||.|....|. ..
etllekefkllkeavnd.tfdsas.keenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessiv

VMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNM-LRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKTLQRKSPNSP
|||. . |  .  . .|||.|   |.|.... . ||   . .  . | ........  |.. |||   |...|.      .... .. ..  ..|. . |
vmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat.slldllkrirksrektqsgP

ILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
| .|||. .||   |..  |.....|  .|.|||.||...|.  .  ||.. |||.|.    ..|. ..| 
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 253-512 9e-24 78.4 In-house 25-285 (302) alignment 
Range on Protein: 253-512
Range on HMM: 25-285/302.0
VTGFEAQFNVLEQVSVPPQDavCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINA--VFIPSYKndKGFIIAQSPLRETR---RDFWKMIFDREITT
 .  ...|. .... |. .   | . .....||. ...   |. .| |. |  .|.||  | .|. .  .  |.|| | ...     .||.|.|...|..
taevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivs

IVMLspIMEGEE-EACAQYWP--KEGTIEFGEFTISVRE--EWGHQSFSRKL-LLIRNNKNNMLRRLAHFqvDGWSNDDITsCNEGAIINTMNLVkTLQR
.|.|  ..| |  ..  ...|   .   |.|.. . .|   .   . .   . .|  .  | .|  . ..  . | .. .   . ...|.|.  |   . 
vvil..vgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvp.vkyaeliktaakv.fakk

KSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
 . ......   | .|| ..| .....|....... . . ..||..| . | ||..  || ...  .. |.
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_egg_pd Subfamily egg 253-512 4.8e-18 59.9 In-house 13-270 (307) alignment 
Range on Protein: 253-512
Range on HMM: 13-270/307.0
VTGFEAQFNVLEQVSVpPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSE----SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTI
| ..| ...|||...   .     ..  .  | | . .   |  ||.|. .    . |.| |  .        ||.||.||..|  |||.|.|  |.  |
vqelerrlevleesvd.eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLSPIMEGeeEACAQYWPKEG--TIEF--GEFTISVREEWG--HQSF-SRKLLLIRNNKNNmlRRLAHFQVDgwsndDItscNEGAIINTMNLVKTLQR
|||.   |   | |  ||||    .. .  | . |   .        |   || |.  ....  | | |.| |          | . .   ..... |..
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddee..rflehwqgd.....vn...nssdvysplrvlrklrn

KSpnSPILMHCSNMIGRSAVFCAAMATV-DQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
 |   |..... . . ..|.. |.  .. . ..       | ..|. .| . . .|.   .| ... | . ..
ls..kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 254-511 6.4e-52 171.5 In-house 26-283 (297) alignment 
Range on Protein: 254-511
Range on HMM: 26-283/297.0
TGFEAQFNVLEQVSVPPQDAVcdVARQHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNdkGFIIAQSPLRETRRDFWKMIFDREITTIV
. |. .|. | .  . ||       .    |.||. |||.|. ||.|..       ||.|| |....|.   .|  | | ..|  |||.|..| ...|||
dvfseeflclpeaniqpqtva..ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstiv

MLSPIMEGEEeACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITS-CNEGAIINTMNLVKTLQRKSPNSPI
||.   |...  ||.||...|. .||. .. .      . |... | ....|. . | .  .|   | ....    .  .... .. |.    .  ..|.
mlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
|.||.. .|| .|...    | ..|    ||.|..|| .| . |  || | |||... .   .
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 254-512 8.7e-37 121.6 In-house 6-259 (267) alignment 
Range on Protein: 254-512
Range on HMM: 6-259/267.0
TGFEAQFNVLEQVSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSP
. .| .|. ....|   .   . .| .   .||... || |. || |. .  .|||| .. .||  . ||. | ||. |  ||...| |.....||.| .
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

IMEGEeeaCAQYWPKE--GTIEFGEFTISVREEWGHQSFSRkLLLIRNNKNNMLRRLAHFQVDGWsndDITSCNEGAIINTMNLVKTLQRKSPNSPILMH
. ...     ..|| .   . .. ..|.    |   . .   . |  . ||.  . .. .    |   .| . |.  .   . ..   | .  | |....
vftdn...irlfwPPkmgqakkyqdltvehslekeendyqi.itlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvva

CSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
||. .|||  |  . . ....|  .|.|.|. ....|   .| |. | .|  || | | | 
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 254-511 8.1e-32 105.4 In-house 16-276 (307) alignment 
Range on Protein: 254-511
Range on HMM: 16-276/307.0
TGFEAQFNVLEQVSvpPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSE--SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVML
. .  .|.|| . .  |.    .  .  . |||||..   |. |. .| .  . ||| | ..    . | || || || .|. .|| |. . .. ...||
qalvdefrvlakkt..pegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

SPIMEGEEEACAQYWPKEG--TIEFGE--FTISVREeWGHQSFSRK--LLLIRN---NKNNMLRRLAHFQVDGWSNDDITSCNEGAIintmNLVKTLQRK
  ..|  .  | |||| |   .  |||   |||| .  | . ..    |. . .   .  .  | . |.| . | .  .   | .||    ||... . .
ckvielakikceqywpleegqklvfgeapntisvan.lgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltai....nlleavryd

spNSPILMHCSNMIGRSAVFCAAMATVDQM-KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
  . |...|||  .|||    |     |.| .     |. . |...| . . |.|.. ||  .| .   |
..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 254-326 1.5e-06 22.3 In-house 23-94 (95) alignment 
Range on Protein: 254-326
Range on HMM: 23-94/95.0
TGFEAQFNVLEQVSVPPQDAVCDVArqHPRKNRYQEILPTDQWRVHLKSE-SPDYINAVFIPSYKNDKGFIIAQ
  |. .|. .   |  |  .    |     |||. .|.| |  || | .    |||||.|.  |   . .| ||
qefdnefksismtsgapytvgssea..nipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
0046845 (Phosphotyrosine protein) phosphatases II 255-518 7.8e-65 214.4 In-house 1-280 (284) alignment 
Range on Protein: 255-518
Range on HMM: 1-280/284.0
GFEAQFNVLEQVSVPPQ-DAVCDVARQHPRKNRYQEILPTDQWRVHLKS-----ESPDYINAVFIPSY-----KNDKGFIIAQSPLRETRRDFWKMIFDR
|.|..|  | .. |..  .  . .. ..  ||||. ||| |..||.|||     |. ||||| ... |     .. | ||..| || .|  |||.|... 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

EITTIVMLSPIMEGEEEACAQYWPKEG-TIEFGEFTISVREEWGHQSFSRKLLLIRNNK-NNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQR
....|||| ...| . | |||||| || ....|.||. ...|. .... .  | ..|.. ..  |.. ||.. .|  |. .  .   ... ..||..|..
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrelle

K-SPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSS---VVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
. ....||. |||. .||...|.|..   .|..  .   .|||...|| .|   ||.||.  ||.... ... |..|. | 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_PTPRA_pd Subfamily PTPRA 255-511 2.2e-57 189.4 In-house 33-294 (330) alignment 
Range on Protein: 255-511
Range on HMM: 33-294/330.0
GFEAQFNVLEQVSVppqDAVCDVARQ--HPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTI
 |  .|| |   ..   .|....| .    .|||. .||| |  ||.|      |. ||||| ||  ||. . || || |..||  |||.||.... .||
lfreefnalPagpi...qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati

VMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIR----NNKNNMLRRLAHFQVDGWSNDDITSCNEGaIINTMNLVKTLQRKSP
|||. . | .|| ||||||.||.. .|. ...|..|   .... . .|..    . ...  | .. |   .| .  . .   | ... .. ||.|...| 
vmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG.mlkllkkvkklnqqsa

NsPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
. || .|||  .||.  |..  | ....|.  .||||..||..| . |  || . ||..|.     |
g.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
DSPc_SM00195 256-512 2.1e-61 202.9 In-house 2-262 (263) alignment 
Range on Protein: 256-512
Range on HMM: 2-262/263.0
FEAQFNVLEQVSVPPqdAVCDVAR-QHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVM
....|. ||.   |    . .... .  .||||..||| |. ||.||.|      ||||| .|  ....| .|..| || .| .|||.|........|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWGHQ-SFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQRKSpNSP
|.  .| ..| |..|||.|  |. .||.... ..|.  .. .. .. | .......  |.. ..|. .| . ..   ..  ... .. ||. ...| ..|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp.dstksvlellravkksksts.sgp

ILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
|. |||. .||...|...   ...... . ||.|..||..| . ||.||.. ||..|.. ...|.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 256-512 2.1e-61 202.9 In-house 2-262 (263) alignment 
Range on Protein: 256-512
Range on HMM: 2-262/263.0
FEAQFNVLEQVSVPPqdAVCDVAR-QHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVM
....|. ||.   |    . .... .  .||||..||| |. ||.||.|      ||||| .|  ....| .|..| || .| .|||.|........|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWGHQ-SFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQRKSpNSP
|.  .| ..| |..|||.|  |. .||.... ..|.  .. .. .. | .......  |.. ..|. .| . ..   ..  ... .. ||. ...| ..|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp.dstksvlellravkksksts.sgp

ILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
|. |||. .||...|...   ...... . ||.|..||..| . ||.||.. ||..|.. ...|.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 256-519 1.3e-58 193.5 In-house 22-287 (318) alignment 
Range on Protein: 256-519
Range on HMM: 22-287/318.0
FEAQFNVLEQVSVPPQDAVCdVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVML
...... |....  .      .     .||||. ||. |. ||.|.     |. ||||| .|. |...| .| ||.|| || .|||.|..... ..||||
lseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

SPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNSPILMH
. ..|   . ...|||..|....|. .. ..||   ...  . . .......  |    ...  |.. .. . . . ... .  |.. |.|| ..||..|
tqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpe.sgaslldlvrqvskaqqksgagpivvh

CSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
||  .||  ||.|  . ....|  ..||||||||..| . .  || . ||..|..    ... . | .
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 256-507 2.7e-51 169.2 In-house 20-271 (515) alignment 
Range on Protein: 256-507
Range on HMM: 20-271/515.0
FEAQFNVLEQVSVPPQDaVCDVARQHpRKNRYQEILPTDQWRVHL----KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVML
|  .|. |    . ||  |..    . .||||..||| |. || |     .   ||.|| .|||..||| .| .| |.. .  |||..... ..|||.|.
fseefhdlpgpniypqt.vaqeeinf.kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

SPIMEGEEEACAQYWPK--EGTIEFGEFTIS-VREEWGHQSFSRKLLLIRNNKnnmLRRLAHFQVDGWSNDDITSCnEGAIINTMNLVKTLQRKSPnSPI
.   ||.   |..|||.    ...||.. .. |  |   .   ||| ......    | .. |.  .| .  .      ...  .  ||. . .    |.
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkh.tssllklikevkadhgqyt.hpl

LMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
..|||  .||  |.....  | ..| . .||||..|.|.| . |  || . || .|.  
iihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 256-506 5.4e-31 102.5 In-house 22-273 (439) alignment 
Range on Protein: 256-506
Range on HMM: 22-273/439.0
FEAQFNVLEQVSVPPQDAVCDVARQH-PRKNRYQEILPTDQWRVHLK----SESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVM
|.  |. .. .| . .   . .|...   ||||... . |  || |.         |||| .|  | .|| .| .| | .||  |||......  .||||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LSPIMEGEEeacaqYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLIRNN--KNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNSPI
|. ..|        ||| .. . .|. .. |  .     .  . . . |.  ...  | . .|.   | . .. . .   ... .  ... . |    |.
ltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpa.qashvldflrainsandkeeygpv

LMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
..|||  .||.    |   ...|.|.   ||.   || .| .    ||.  || .|. 
vvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyn
subfamily_PTPRN_pd Subfamily PTPRN 257-513 1.3e-33 111.0 In-house 32-293 (297) alignment 
Range on Protein: 257-513
Range on HMM: 32-293/297.0
EAQFNVLEQVSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKN-DKGFIIAQSPLRETRRDFWKMIFDREITTIVML
|.... | .    |. .    | .  .|||....|| |. ||.||.|.     ||||| .|         .| .|.|| .|  |||.|.... .. ||.|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

SPIMEGEEEACAQYWPKEGTIEFGEFTISVREE--WGHQSFSRKlLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKTLQRKsPNSPIL
... | . ..|..|||.||.  .. . . .  |  | .. . |  . ..| ...  | .. |    | . .. .    ....    |    |    .||.
trleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrs.fylknlqtsetrtvtqfhflswpeegvPasak.sllefrrkvnksyrG.rscpiv

MHCSNMIGRSAVFCAAMATVDQM-KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
.|||.  ||. |...    .... |    .|.  |.. .| . || |. | |.... |  |  ||
vhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_ptpA1_pd Subfamily ptpA1 257-471 2.6e-23 77.5 In-house 24-255 (418) alignment 
Range on Protein: 257-471
Range on HMM: 24-255/418.0
EAQFNVLEQvSVPPQDAVCDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYkNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLS
. .| .||. || | ..     ..   |||| .||| .. ||.||     |  ||||| .|      | || .| || .|  |||.|...     |||||
keefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmls

PIMEGEEEACAQYWPKEGTIE-----------FGEFTISVREewGHQSFSRKLL--LIRNNKNNMLRRLAHFQVDGWSNDDITSCNEG------AIINTM
   |     | .|||..   |           || ... . |    |   |...   ||   .   | ....| .|| . .|    .       .| |  
resencrikcdrywpeqiggeqfsiygngnevfgtysvelve..viqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

NlvKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQ
|  . .     | ||..|||  .||.  ||.|.  . .
n..qiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 260-387 6.1e-24 79.1 In-house 26-167 (392) alignment 
Range on Protein: 260-387
Range on HMM: 26-167/392.0
FNVLEQVSVPPQDAVCdvARQHPRKNRYQEILPTDQWRVHL----KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIM
|  | .  . || .         .||||..||| |. ||.|     .   ||.|| .|||..|.| .| .|.|   .  |||.|.|. ..|||.|.. . 
fhdlpgpdiypqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

EGE----EEACAQY----WPKEG----TIEFGEFTISVREEWGH
||.      ..||.    || ..    |  . .|   |. ..|.
egdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq
subfamily_PTPN14_pd Subfamily PTPN14 262-513 7.9e-35 115.3 In-house 28-297 (300) alignment 
Range on Protein: 262-513
Range on HMM: 28-297/300.0
VLEQVSVPPQDAVCDVARQ--HPRKNRYQEILPTDQWRVHLK---SESPDYINAVFIP--SYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPI
  |...   .||....|.     .|||....|| .. ||.|.    .| .||||  |      ... .|.||.||. | .|||.|... ... ||||  .
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

MEGEEEACAQYWPKE----GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEGaIINTMNLVKTLQRK--------
 |.  | . .|.||.     |.|||.| .. .     .|.  . | ..    .  | . |.|   |..... .  .|  .. .. |. ..||        
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkg.flsyLeevqsvrrktnsevesk

SPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
. . |.|.|||. .||. |   .   .  ..   ..|. .... .|      ||. .|||.....   |..
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 268-511 6.3e-47 155.3 In-house 32-287 (325) alignment 
Range on Protein: 268-511
Range on HMM: 32-287/325.0
VPPQDAVCDVA---RQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREiTTIVMLSPIMEGEEE
.|..|..   .    .   |||...... |. || |..     | ||||| .. ..|. . |. ||.|| .|  |.|....| . ...|..  .......
lpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkd

ACAQYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRK-----SPNSPILMHCS
 ||.|||||   . .|| . ...|       .  . | ... |.   | .  ||. .| .         ..|. ..|||... .        .|||.|||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqk.rpatlisilqlvkavservtantkastpilvhcs

NMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
. .||. || .  . ....   | ||.|. ||..| . |  |.   || .|..  . .
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 268-512 3.7e-17 56.9 In-house 35-279 (303) alignment 
Range on Protein: 268-512
Range on HMM: 35-279/303.0
VPPQDAVCDVArQHPRKNRYQEILPTDQWRVHLKSESpdYINAVFIpSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP
.||. .  .   .   |||. ...  |. .|.|   |  || | ..   . .|  |..| ||  |  |||.|| .. .  ...|    | ..      .|
lppsvsknqfv.knmdknrfvdvicldhskvklsdss..yihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

KEG-TIEFGEFTISVREEWG---HQSFSRKLLLIRNNKNNMLRRLAHFQvdGWSNDDITSCNEGAIINTMNLVKTLQRK-SPNSPILMHCSNMIGRSAVF
..   ..| | .| | |       . .. |.| . | . . .  . |..   |  ..| |     ... .  .... || |...| .       ||.  |
rnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtf

---C-AAMATVDQMKSSSVVDVFQTVKNMRVNlpgAVQNKGQYKMIHTLAAAYV
     | ..  ..  |  .| ....|.| |.    ||||  |. ...|| | .|
alfetahlslhseqasldlvkclenvrngrlh...avqnlsqfsvvytllaehv
0045098 (Phosphotyrosine protein) phosphatases II 269-513 1.5e-55 183.9 In-house 21-273 (278) alignment 
Range on Protein: 269-513
Range on HMM: 21-273/278.0
PPQDAVCDVARQHPRKNRYQEILPTDQWRVHlksespDYINAVFIPSYknDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK
.|..  . . . .  |||| .||| |. ||.      ||||| .|..|  .| ||..| || .|  |||.|...  ||.|||| . .|.. | |||||| 
ipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

EGTIEFGEFTISVREEWGHQSFSRKLLLIRNN----KNNMLRRLAHFQVDGWSNDDITSCN-EGAIINTMNLVKTLQR------------KSPNSPILMH
.|....|.||. . .|  .. .    ||..|     .... | . |..  .|   .. | .    ... .. ..  ..             ... |.| |
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSNMIGRSAVFCAAMATVDQMksSSVVDVFQTVKNMRVNLPG-AVQNKGQYKMIHTLAAAYVN
||  .||.....||.   ...   ..||....|| .|   || ||||..||. .. ... ...
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN13_pd Subfamily PTPN13 270-506 2.2e-43 143.5 In-house 25-263 (273) alignment 
Range on Protein: 270-506
Range on HMM: 25-263/273.0
PQDAvCDVARQ--HPRKNRYQEILPTDQWRVHLKSESPdYINAVFI--PSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQY
|.|  |.|...  . .||||...|| |. ||.|..|.. |||| .|  |  |.   .|..| || || .|||.|..... . |.|..   |...  | .|
pldt.cevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPKEG--TIEFGE-FTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKTLQRksPNSPILMHCSNMIGRSAVF
||..   ..   . ..... .   ...|. . | ..... .  |..||..   | . .. |  .  ... .  |..||.   ..||..|||  |||| ..
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaa.ellqfvaevrrlqt..dagPivvhcsaGiGrsGtl

CAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
 .  . .. ..    .|| ..|...|    | || | || ... 
itidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 270-514 2.7e-43 142.9 In-house 10-266 (270) alignment 
Range on Protein: 270-514
Range on HMM: 10-266/270.0
PQDAVCDVARQHpRKNRYQEILPTDQWRVHLKSESP----DYINAVFIPSY-KNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQ
 .... ..||.. . |||..|||. . || |....      |||| ... . ...| .| |..||  | ..||.||.... |.|||.....|   . |..
sesdlpeaargk.klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer

YWPKEG----TIEFGEFTISVREEWGHQSFSRKLLLIRnnKNNMLRRLAHFQVDGWSNDDITSCNE-----GAIINTMNLVKTLQRKSPN-SPILMHCSN
|||.|     ..|.|. .. . .|  .. . .. | ..  ..   ||| ||.   | .. . . ..       ...... |.  ...  . .|.|.|||.
YWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

MIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNL
 .||. .. |   .|  ..... ||| . ....| . .  ||   ||....   . |.. 
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_CG7180_pd Subfamily CG7180 271-512 3.9e-47 155.3 In-house 32-290 (296) alignment 
Range on Protein: 271-512
Range on HMM: 32-290/296.0
QDAVCDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeACAQYW
 |  ...  .   |||. ...| |. || |..    |. ||||||.. |.  .| .|. . | .||  .||....|.|| ..|.|.  .. ..  . .||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PKEGTIEFGEFTISVREEWGHQSFSRKLL-LIRN---------NKNNMLRRLAHFQVDGWSNDDITSCNEGAIINTMNLVKTLQRKS----PNSPILMHC
|...  ..||. . . ||     .  . . | ..         . .   | . .||.  |  .|       |.|. .. |.....|      ..|.....
pnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
|.  .|| |..|. |......    ||||. || .| . |. |.|. .|| |  .   .|
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 271-506 1.8e-46 153.9 In-house 15-249 (284) alignment 
Range on Protein: 271-506
Range on HMM: 15-249/284.0
QDAVCDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSpimegeEEACAQYW
 |       |   |||. .||. |. .| |.     |  ||||| ||  |.. . .| .| || .|  |||.||.. ...|||.|.      .. |.|||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PKEGTIEFGEFTISVREEWGHQSFS-RKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRK-SPNSPILMHCSNMIGRSAVFCA
|... |. ..| ..|      . .  |.. | .. |..  |..  |   || .      .   ..  .. |. |..|   ...|..|||  .||. |. .
plkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp.sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
  . .|.||  . |||...|...| . .  ||.  |||.|..
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 272-489 7.5e-13 42.8 In-house 34-256 (312) alignment 
Range on Protein: 272-489
Range on HMM: 34-256/312.0
DAVCDVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK-EG
|. |    .    ||| .|   |. |  |  .   || | |.    . . |...|.|| .|   ||.. .    |.|..|. ..|   | ||.|     |
dsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

TIEFGEFTI---SVRE-EWGHQS---FSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEGAiintMNLVKTLqrKSPNSPILMHCSNMIGRSAVFC
 ... .  .   .. | | | .|    . ..| .  .      .| |.|   | .  .    . |    . |. ..  |  . |.. |||  .||.  ..
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdta....lrllsav..kkdkkpviahcsagvgrtgtla

---AAMATVDQMKSSSVVDVFQTVKNMRV
   . .|.. . .   | |.|  ... | 
liesmiaalrhprkqnvkdsfvllrkdra
subfamily_PTPN12_pd Subfamily PTPN12 273-512 4e-49 162.0 In-house 32-277 (290) alignment 
Range on Protein: 273-512
Range on HMM: 32-277/290.0
AVCDVARQHPRKNRYQEILPTDQWRVHLKSE----SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK
. .  . .. .||||..||| |. ||.|. .      ||||| ||   .... .| ||.|| .|  |||.||.. ... .||.  ..| .   |..|||.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

E--GTIEFGEFTISVRE-EWGHQSFSRKLLLIRNNknNMLRRLAHFQVDGWSNDDITSCnEGAIINTMNLVKTLQRkSPNSPILMHCSNMIGRSAVFCAA
|   ..|||||.... | .. .. |  . | ....  .  |..  |.   | . .. |  .  ... ..||..||. | ..|...|||  .||  . .| 
egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPss.aksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiai

MATVDQMKSSSV---VDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
  . ...|.  .   .|||. | ..| . . .|| | ||....   | .|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN9_pd Subfamily PTPN9 273-507 5.4e-49 161.8 In-house 34-285 (297) alignment 
Range on Protein: 273-507
Range on HMM: 34-285/297.0
AVCDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP-
. .   |   .||||...|  |. ||.|..    |  ||||| |.  ||. |.|| .| ||..| .|||.|....|. .|||   ..|     |.|||| 
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

-KEGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQR------------KSPNSPILMHCSN
 .| ..|||....|. |   .. .  . | |.| |..  |.. |||. .| .  . |    .... .. |.  |             .  . ||..||| 
eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssa.aslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

MIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
 |||.  |..   ....... ..|||..||| .|     ..|   ||.. .  
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 274-373 4.5e-17 56.6 In-house 45-147 (310) alignment 
Range on Protein: 274-373
Range on HMM: 45-147/310.0
VCDVARQHPRKNRYQEILPTDQWRVHL---KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG
  .  ...  |||| ...  |. ||.|   ||   ||| | .. .    . || .| ||. |  |||.|||.    .|..|  ..|     |  |||  |
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

TIE
  |
vte
0040439 (Phosphotyrosine protein) phosphatases II 275-511 1.6e-57 190.3 In-house 5-245 (249) alignment 
Range on Protein: 275-511
Range on HMM: 5-245/249.0
CDVARQHPRKNRYQEILPTDQWRVHLKS----ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG
.     .. ||||. ||| |. ||.|..    .  ||||| .|. |.  . ||..| || ||  |||.|...  ||.||||.. .| . | |||||| .|
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

TIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKS-PNSPILMHCSNMIGRSAVFCAAMATV
..|.|.||. ....  .... .  | . |....  |.  |.|. .|  |. .. .   ... ...|.. ...  ...|.| |||. .||...|.||   .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

DQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
.|..    ||....|| .|   |||||| .||. .. ... .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN1_pd Subfamily PTPN1 276-502 1.3e-38 127.4 In-house 25-261 (290) alignment 
Range on Protein: 276-502
Range on HMM: 25-261/290.0
DVARQHP--RKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG---
 .|...    .|||... | |  |..|.... ||||| ..   . .. .|..| || .|   ||.|.....  ..|||  ..| |.  ||||||..    
reaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

TIEFG--EFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRKSP-NSPILMHCSNMIGRSAVFCA---
....   .... . .|  .. . ..|| . | | .  | . ||    |..  . ..  .| .. .  |.     |.   | ..|||  ||||  ||    
ellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpesp.aaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

AMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYK
 .. ... .  | ||. ... ..|    | .| . | .
clvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 276-511 9.1e-27 88.8 In-house 38-270 (288) alignment 
Range on Protein: 276-511
Range on HMM: 38-270/288.0
DVARQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIE
|.  . | ..||...   |  ||.|. ..  ||.|  ..| |... .| ||.||. |   .|||... ..  ||||. ..|   |. |.|.| .   .. 
dsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRR-LAHFQVDGWSNDDITScnegAIINTMNLVKTLqrKSPNSPILMHCSNMIGRSAVFCAAMATVDQM
.| .   |...        |. |.|..|.   .  . .  .  | .| .        .  ..|.. |  || . ||..|.|. .||.. .   .  ....
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPe....nylsplrllevl..kslqkPivvhssaGvGrtgtlililialesl

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
...  . . . ....| .   |.| . ||  .| .   .
rlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 278-508 4.1e-53 175.2 In-house 39-273 (315) alignment 
Range on Protein: 278-508
Range on HMM: 39-273/315.0
AR--QHPRKNRYQEILPTDQWRVHL----KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--E
||  .  .||||..||| |. || |    .|   ||||| .|.|...|| .| .| ||. .  |||.|... ..|||||..   ||.   |.||||.   
aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

GTIEFGEFTISVRE-EWGHQSFSRKLlLIRNNKNnmLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLqRKSPNSPILMHCSNMIGRSAVFCAAMAT
 ..|||.. ... . |   .   |||  .|. ..   |... ||  .| .  .   . ..... .  ||.  ... . ..|.|||  .||. |.....  
dsvefGsikvellsleadtdgvarkl.vtrksee..srtvtqfqftewPdkGvdk.qtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidev

VDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
|.|.| ...||||..|||.| . |  || . .| .|.   
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_CG42327_pd Subfamily CG42327 278-432 1.9e-18 61.2 In-house 25-186 (319) alignment 
Range on Protein: 278-432
Range on HMM: 25-186/319.0
ARQHPRKNRYQEILPTDQWRVHLKSE----SPDYINAVFIPSYKNDK-GFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE---
      |.|. ...|  . || |..     .  |..| ..  |.. .  .| || .| ..  |||......   .|| |. . |   . ||.|.| .   
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

-GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVdGWSNDDITScNEGAIINT
 .|  .|.. .....   .. .    ||... .... | |.|.    | . .. . .| |.|  
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPa.eeaaliam
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 278-385 2.7e-18 60.8 In-house 44-166 (350) alignment 
Range on Protein: 278-385
Range on HMM: 44-166/350.0
ARQHPRKNRYQEILPTDQWRVHLK-----------S-ESPDYINAVFI----PSYKNDKGF--IIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEE
  .   ||||..||| .. ||.||           | .. ||||| ..    .| . . .|  | .|.||..|  ||.|.|.  ... |..|.. .| . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

EACAQYWPKEGtieFGEFTISVREEW
| | .||.. .   . ..|. . . |
ekcyrYWqegs...ydditvklaskw
subfamily_PTPRK_pd Subfamily PTPRK 279-507 1e-49 164.1 In-house 41-272 (314) alignment 
Range on Protein: 279-507
Range on HMM: 41-272/314.0
RQHPRKNRYQEILPTDQWRVHLKSE----SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIeF
 .. .|||...||. |. || |..     | ||||| .| |||. . ||..| ||.|| .|||....| . ..||||. ..|     | .|||..... .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.y

GEFTISVRE-EWGHQSFSRKLLLIR-NNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQRKsPNSPILMHCSNMIGRSAVFCAAMATVDQM
|.. . . | |   .  .| . . . . . .  | . .||  ||.. |.  ... .... .  ||. | .  . .|..|||.  ||. .|.|    .| .
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvP.vsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
.  .|||||..||..| . .  |. . |||.|.  
eregvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 279-509 1.5e-28 94.6 In-house 33-267 (285) alignment 
Range on Protein: 279-509
Range on HMM: 33-267/285.0
RQHPRKNRYQEILPTDQWRVHLKSESPDYINAVFIPSY-KNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFG
   |  ||| ..   .. || ||    ||| | ..    |..  .| .| || ||  |||.||.. .|. ..||  ..||  | || |.|..    ..||
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

EFTISVRE---EWGHQSFSRKLLLIrNNKNN--MLRRLAHFQVDGWsNDDITSCNEGAIINTMNLVKTLQRKspNSPILMHCSNMIGRSAVFCA-AMATV
.. |.. |   |    .    | .| | ..       . | ||  |  |...  .   .|.  . || .. |  . || .|||  .||.| |     ||.
kyeitlteckeeaiagtilnaltvi.ntedasseplymnhvqvpww.pdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyati

DQMKSSsVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAA
  |.    ..... |..||     |||.. |. ... .  
rimenp.niemldivremramrfqavqshmqflflyvvlm
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 279-503 3.3e-18 60.8 In-house 17-250 (290) alignment 
Range on Protein: 279-503
Range on HMM: 17-250/290.0
RQHPRKNRYQEILPTDQwRVHLK----SESPDYINAVFIpSYKNDKGFIIAQSPLRET-------RRDFWKMIFDREITTIVMLSPIMEGEEE----ACA
..|  ..|..  | ..  || ||      . ||| | .. .. |.  .|. |||. ..         .|| |. . ... .|||   .| ...    |||
kkhemdqRlevpLveat.rvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

QYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLrRLAHFQVDGWSNDDITSCNegaiINTMNLVKTLQrkSPNSPILMHCSNMIGRSAV
.| |..  . . |. .|..  .   .. . .. |... .... .  . | .. ||..  .   .    .  ..|.....    ..|...|| . | |||.
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedt....ktllsliqkvk..asktpvivHcvdGiSrsAa

FCAAMATVDQMK-SSSVVDVFQTVKNMRVNLPGAVQNKGQYKM
. |       .  .|. | . . .|..| .   |.... ..  
laaiilgyQkiaetsgsvkledvlkalrkqralaitsalelaf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 280-516 3.5e-58 191.8 In-house 8-246 (250) alignment 
Range on Protein: 280-516
Range on HMM: 8-246/250.0
QHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEaCAQYWPKEGTIEFG
|   |||| .|.. |. || |..|.     |||||.|. .|.. | ||..|.|| .|  |||.|.......|||||. . | |.. . |||| |.. ..|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

EFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSS
. |.|. ..  .  .  . | . ..|..  | . ...   | .  .   .  |... .. |.. |... |.|....||. .|||  |.|  | ....| .
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPe.vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFS
 |||||. .| .| . |.||. . || ......  ... ..
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
0042113 (Phosphotyrosine protein) phosphatases II 280-512 2e-56 186.5 In-house 8-243 (245) alignment 
Range on Protein: 280-512
Range on HMM: 8-243/245.0
QHPRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFG
 .. |||| .||| |. ||.|....     ||||| ... |.  ..||..| ||.||  |||.|...  |||||||.. .| . . |||||| ......|
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

EFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSS
.||. ...|  .... .  | . |....  |   |..  .|  |. .  .   ... ...|.. .....| |.| |||  .||...|.||   ..|... 
dftvtllseehlddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
  |.....|| .|   |||||. .||. .. ... ..
lgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 280-510 1.1e-49 164.5 In-house 9-240 (243) alignment 
Range on Protein: 280-510
Range on HMM: 9-240/243.0
QHPRKNRYQEILPTDQWRVHLksESPDYINAVFIPSYKNdkgFIIAQSPLRETRRD----FWKMIFDREITTIVMLSPIMEGEEEACAQYWPkeGTIEFG
..  ||||. ||| |. ||.|  |. ||||| .|. ...   .|. | || ||  |    ||.|...  ||.|||| . .| . | ||||||  |....|
enlsknrysdilpydhsrvkl..egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtyg

EFTISVREEWGHQSFSRKLLLIRNNK-NNMLRRLAHFQVDGWSndDITSCN-EGAIINTMNLVKTLQRK-------SPNSPILMHCSNMIGRSAVFCAAM
.||. . .|  ....    ||..| . ..  |   |..  .|   | .  .    ... .. |.. ...       ....|.| |||  .||.....|| 
dftvtllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

ATVDQMkssSvVDVFQTVKNMRVNLPG-AVQNKGQYKMIHTLAAA
   ...   . ||....|| .|   || |||. .||. .. ... 
lmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 280-513 2.3e-49 162.9 In-house 27-269 (274) alignment 
Range on Protein: 280-513
Range on HMM: 27-269/274.0
QHPRKNRYQEILPTDQWRVHLKSES-----PDYINAVFIPSYKN-DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI-
 . .||||..||| .. || |.|||      .|||| .|  |.. .| .. .| || .|  |||.||. .|.. ||||  . | .|. ||.|.|..  . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---EFGEFTISVREEWGHQSFSRKLLLIRNNKNnmLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRK--SPNSPILMHCSNMIGRSAVFCAAMA
   ..|.. | |..   .. .| . |.... ..   |.. |.    |  |  .  .  ....... |.. ...   . .|...|||  |||  .| |.  
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

TVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
.| |.. ..||||...| |.|..  | ||.. ||..||   . |..
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 280-506 1e-46 154.2 In-house 40-270 (280) alignment 
Range on Protein: 280-506
Range on HMM: 40-270/280.0
QHPRKNRYQEILPTDQWRVHLKSESPDYINAVFI----PSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEF
.   ||||..||| |. ||.||... ||||| ..    || .  . .|..| ||..|  |||.|........||||  ..|     | ||||..  ..|.
enlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeley

GEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLqRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS
|||.. ...|  ..|.  . |........  |.. ..|   |.. .. . .   ... .. |..| |.. ..|...|||  |||. |. .   ..  . .
gefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds.adflefvervrkl.rsgkeePvvvhCsaGigrtGvlilletalaliea

SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH-T
.  | . . |..||      ||...|||..  .
aepvypldivrtmrdqramlvqtasqykfvCea
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 280-512 2.6e-23 77.2 In-house 47-287 (305) alignment 
Range on Protein: 280-512
Range on HMM: 47-287/305.0
QHPRKNRYQEILPTDQWRVHLKSESP-DYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGE
|.  ||||...   |. ||.|..  | .|| | .. .  | | || .|.|| .|  ||| | ..  . .| ||  ..|   . |..|.. .   ..|| |
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

--FTISVREEWG-HQSFSR-------KLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCnEGAIINTmnLVKTlqrKSPNSPILMHCSNMIGRSAVFCAAM
    |||. |     .| .       .  |. .   .  |. .|.    | .  . .  . ||..   | |.   ..   || .|||  |||.       
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa.dlailel..leka...rpskgpivvhcsagigrtgsvvmle

ATVDQMKSSSVVDV-FQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
  .||. .  ...   . .. .| .   ..|   || ..| .   |.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0049772 (Phosphotyrosine protein) phosphatases II 280-512 4e-21 71.5 In-house 45-280 (314) alignment 
Range on Protein: 280-512
Range on HMM: 45-280/314.0
QHPRKNRYQEILPTDqWRVHLKS---ESPDYINAVFIPSYkndKGFIIAQSPLRETRRDF----------WKMIF--DREITTIVM--------------
 .. ||||..||| |  ||.|..   .. ||||| .. ..   . ||..| || .|  ||          |.|..  |. . .|||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LSPIMEGEeeacaqywpkegtieF----------GeftisvreewghqsfsrkllL-------IrnnkNNMLRRLAHFQVDGWSNDditscNE
       | .....                                                              ..  .. .. |...| .      .
aAlgKtpllildgng...............neptaadlellk....................eelydpelf....erlgikylripvpDgsap.....ll

GAIINTMNLVKTLqrkSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSsSVVDVFQTVKNMRVNLP--GAVQNKGQYKMIHTLAAAYV
  .   .......   ....|.|.||.  .||...|..|.  . ...  |. .... |...|   |  |....  || .|.     |.
edfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 281-503 9.5e-29 95.1 In-house 50-272 (301) alignment 
Range on Protein: 281-503
Range on HMM: 50-272/301.0
HPRKNRYQEILPTDQWRVHLKSESP-DYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEF
.  |.||...    .  |.. ..     | | .||.  . . ||..|.||..|. ||| |.   .. .||||.  .| .|| |..| | .   ... | |
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

TISVREE---WGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKtlqrKSpNSPILMHCSNMIGRSAVFCAAMATVDQMKS
.| ....     ..   |.| .    ..   | . |.|   |.. ..       . . |.|||    || . ||..|||. ||||  | ..     ....
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksh.aelfdlmelvk....ks.ekPivvhcsaGiGrsvafigteylarevea

SSVVDVFQTVKNMRVNLPGAVQNKGQYKM
   ... ...|..| .   .||.. |   
dptieltealkhlrehrwngvqtnsqlyw
Y_phosphatase Protein-tyrosine phosphatase 282-508 3.9e-61 201.8 Pfam-A 2-233 (235) alignment 
Range on Protein: 282-508
Range on HMM: 2-233/235.0
PRKNRYQEILPTDQWRVHL-KSES-PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP--KEGTIEFGEF
 .||||..||| |. ||.| .||.  ||||| .. .||..| ||..| || .|  |||.|........||||   .| ..|.||||||  .|.. ..|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TISVR--EEWGHQSFSRKLLLIRNNKNN-MLRRLAHFQVDGWSNDDITSCNEGAIiNTMNLVKTLQrKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS
.. ..  |.  ....  . | ....|..   |.. .... .| . .. ..... . .... |.. . .. ..|.. |||. .||...|.|... ..|...
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
 . |||.|.||..| . ||.||.  ||.... . 
eeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 282-508 3.9e-61 201.8 In-house 2-233 (235) alignment 
Range on Protein: 282-508
Range on HMM: 2-233/235.0
PRKNRYQEILPTDQWRVHL-KSES-PDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP--KEGTIEFGEF
 .||||..||| |. ||.| .||.  ||||| .. .||..| ||..| || .|  |||.|........||||   .| ..|.||||||  .|.. ..|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TISVR--EEWGHQSFSRKLLLIRNNKNN-MLRRLAHFQVDGWSNDDITSCNEGAIiNTMNLVKTLQrKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS
.. ..  |.  ....  . | ....|..   |.. .... .| . .. ..... . .... |.. . .. ..|.. |||. .||...|.|... ..|...
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
 . |||.|.||..| . ||.||.  ||.... . 
eeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 282-505 1.1e-34 114.4 In-house 55-276 (290) alignment 
Range on Protein: 282-505
Range on HMM: 55-276/290.0
P--RKNRYQEILPTDQWRVHLKSESP-DYINAVFIPSYKNdkGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK-EG-TIEFGE
.  .||||...   |. || ||   . ||. | ..   |    ||..| .|..|  |.|.|. . ....||||  ..|     |.||.|. || .. |||
tefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FTISVREEWGH-QSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLqrkspNSPILMHCSNMIGRSAVFCAAMATVDQMKSS
.|.   ||  . .   .|.| .|. ..    .| |...  | .  ..  .  |.. |.  ....     . |. .|||  |||.  | |  .... .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst.lallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldG

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
  .|. ..|. .|    ..||   || .. 
keldlldlvralrnsrlnsvqvdiqylalv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 282-511 1.1e-34 114.5 In-house 39-276 (287) alignment 
Range on Protein: 282-511
Range on HMM: 39-276/287.0
PRKNRYQEILPTDQWRVHLKSE---SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK-EGTIEFGEF
 .|||| ..|| |. || |  |     ||||| ...||..|. || ||.|.  | ||||....... .......  .|     | .|||. |  .  | .
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGy

TISVREEWG-HQSF-SRKLLLIRNNKNNmLRRLAHFQVDGWSNDDITSCNEGAIINTMNL--VKTLQRK-SPNSPILMHCSNMIGRSAVFCAAMATVDQM
.. . .    .  .  | | ||  . ..  | .  ...  | .. ..    | |  ...      |.|. |   |...|..  |||| .. | .. |...
svvlldydikePeygvralrlidletre.arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
..   ||| ..|  .|    . ||   |....    ..|
edlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 282-510 1.5e-29 97.8 In-house 33-293 (297) alignment 
Range on Protein: 282-510
Range on HMM: 33-293/297.0
P-RKNRYQEILPTDQWRVHLKSESP--DYINAVFI--PSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEF
  |||||..|| ||. ||.|.   .  ||||| ..  |  ..|  .|.|| ||..|  |||........ .|||.. . |.  . || |||.  ..  . 
slrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

GEFTI----SVREEWGHQSFsRKLLLIRNnknNMLRRLAHFQVDGWSNDDITS--------------CN-----EGAIIN-----TMNLVKTLQRKSP-N
|.. .    |. .|. .  .  .| ||     .  | . | |  .| .  . |              |        |...      .  ...|. . | |
gdvvveflsstsdefdrvil.telqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprn

SPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAA
 ..|.|||  .||| |   ... .....   . ||   .. .| . .  ||   |........ .
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 282-506 2.4e-27 90.6 In-house 9-235 (239) alignment 
Range on Protein: 282-506
Range on HMM: 9-235/239.0
PRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKN-DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKeGTIEFGE
  |||| .|.  |. || |.  |     ||||| ..  |    | .| .|  .  .  |||.|...     ||||. ..|| .. | ||||   | .. .
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stskycn

FTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINtMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSS
. ...|.      .  . ... .  .   | . ....  | .  .      |..  .    | .      | ..|||  .||.  |    | . | |   
lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyat.avlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

VVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
 ||.|. || .| . |  ||   || .|| 
tvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 282-506 2.5e-27 90.6 In-house 8-234 (239) alignment 
Range on Protein: 282-506
Range on HMM: 8-234/239.0
PRKNRYQEILPTDQWRVHLKSES----PDYINAVFIPSYKN-DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKeGTIEFGE
  |||| .|.  |. || |.  |     ||||| ..  |    | .| .|  .  .  |||.|...     ||||. ..|| .. | ||||   | .. .
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stskycn

FTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINtMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSS
. ...|.      .  . ... .  .   | . ....  | .  .      |..  .    | .      | ..|||  .||.  |    | . | |   
lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyat.avlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

VVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
 ||.|. || .| . |  ||   || .|| 
tvdifnyvkairedrphmvqtseqyvfihl
subfamily_PTPRD_pd Subfamily PTPRD 283-519 1.1e-66 220.7 In-house 50-288 (564) alignment 
Range on Protein: 283-519
Range on HMM: 50-288/564.0
RKNRYQEILPTDQWRVHLK----SESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFT
.||||..|.. |. || |.     |. ||||| || .|...| .| .| || || .|||.|.......|||||. . | ... |..|||..|| ..||.|
aKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygelt

ISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQrKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVV
... ||   . .. . . ....|..  |   .|.   | . ..      .... .. |..|. .. . ||. |||. .||. .|..  | ....|.. .|
VtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektv

DVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
|..|.||..| . .  ||.. ||  ||.  . ... ..|. 
DiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 283-506 5.9e-36 118.9 In-house 5-233 (237) alignment 
Range on Protein: 283-506
Range on HMM: 5-233/237.0
RKNRYQEILPTDQWRVHLKSE--SPDYINAVFIPSYKN-DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEFGEFT
 |||| .|   |. || ||    . ||||| .. ..    | .| || ||  .  |||.|...   . ||||. ..||.|. | .|||.      .| .|
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

ISVREEWGHQSF-SRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSV
.|.. .     .  | ||| .. . . .| .  .|   | .  .       .    |...  .  |  .| ..|||  .||...|    | . | |   |
vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkv

VDVFQTVKNMRVNLPGAVQNKGQYKMIHT
||... |...  . |  .| | || .|| 
vdiynyvysieedrpyiiqtkdqyvfihq
0041856 (Phosphotyrosine protein) phosphatases II 283-510 1.4e-31 104.9 In-house 3-169 (182) alignment 
Range on Protein: 283-510
Range on HMM: 3-169/182.0
RKNRYQEILPTDQWRvhlkseSPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSpimegeeeaCAQYWPkegtiefgeftisvr
 ||||..||| |. |       .||||| .. ..  .. ||..| || .|  ||..|. .. |||||.|.         . .|||               
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

eewghqsfsrklllirnnkNNMLRRLAHFQVDGWSNDDITScnEGAIINTMNLVKTlqrksPNSPILMHCSNMIGRSAVFCAAMATVDQmkSSSVVDVFQ
                   ..  |   ...  .|  .....     ... .. |.      .. |.| |||  .||.....||     .  . |. ....
...................ellerlgiqylylpwpDhgvpd..ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl..gvsleeavk

TVKNMRvnlPGAVQNKGQYKMIHTLAAA
.|...|   ||.|..  || ... ..  
lvrsrR...pgmvitpnqyfflqlalle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 283-511 2.8e-22 73.7 In-house 57-288 (305) alignment 
Range on Protein: 283-511
Range on HMM: 57-288/305.0
RKNRYQEILPTDQWRVHLKSESP-DYINAVFIPS-YKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEFGEFTI
 |||||..   ||  |.|.  || ||| | ..      .| || || || .|  .|| |. .. .  ||||   .|     ||||||   |        |
tknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgi

SVREEWGHQSFSRKLLLIRN-----NKNNMLRRLAHFQVDGWSNDDITSCNegaiINTMNLVKTLqRkSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS
 | .  | . . |   .           .    . |.|   | .  .  |.    . ...|. .. |   . ||..|||  |||.    |    ....  
vvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppck....ltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiae

S-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
  ..  . . || .| .   ..||  || .|| .   |
nkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 284-368 1.5e-07 25.1 In-house 51-155 (349) alignment 
Range on Protein: 284-368
Range on HMM: 51-155/349.0
KNRYQEILPTDQWRVHLKS------------------ESPDYINAVF--IPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACA
||||..||| .  || ||                      ||||| .  .. .. .| .|  | ||  |  ||.|.|   ..  .. |.   | . | | 
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPK
.|| .
iywqe
subfamily_eak_pd Subfamily eak 285-438 5.1e-13 43.1 In-house 56-212 (332) alignment 
Range on Protein: 285-438
Range on HMM: 56-212/332.0
NrYQEILPTDQWRVHLKSE---SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG--TIEFGEFTI
|   .|.| |.  |.| |       ||||  .   .  . .|..  .  .    ||.|....   .||.|   .| . |   .|.|...   ..|| . .
n.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv

SVREEWGHQSFSRKLLLIRnnKNNMLRRLAHFQVDGWSNDDITSCNEG-AIINTMNLVKT
  .|   .. .  .|| ..  | |   |. |..| ||.. ..   ..  |. ..|  | .
erkefvkrniletrllels..kGnethrvlhykvfGwtettlpkyedflalrkvmkevGv
0046846 (Phosphotyrosine protein) phosphatases II 297-510 1.3e-26 88.8 In-house 4-171 (176) alignment 
Range on Protein: 297-510
Range on HMM: 4-171/176.0
RVHLKSESPDYINAVFIPSYKndkgFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFgeftisvreewghqsfsrklll
|..   ...||||| .| ...    .|. | ||..|  ||..|...  ||..|.|   .| .   |..||| . . ..                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

irnnknnmlrrlaHFQVDGWSNDDITSCneGAIINTMNLVKTLQRKSpnSPILMHCSNMIGRSAVFCAAMatvdQMKSSSVVDVFQTVKNMRVNLP-GAV
             .... .|   .. .    .... ...... ...    |.| |||  |||.....||      ....  ..|..... .|   | |||
.............qylhlpwpDhgvpdl..elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QNKGQYKMIHTLAAA
|. .||....  .  
qtpeQyrflyefell
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 301-354 1.2e-08 28.9 In-house 66-120 (347) alignment 
Range on Protein: 301-354
Range on HMM: 66-120/347.0
KSESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVML-SPI
  ..  ||||  |   . .| .|..| || .| ||||||..   .| .| .  ||
addvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
0044763 (Phosphotyrosine protein) phosphatases II 302-508 3e-21 71.3 In-house 15-167 (178) alignment 
Range on Protein: 302-508
Range on HMM: 15-167/178.0
SESPDYINAVFIPSYkndkgFIIAQSPLretrRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTiefgeftisvreewghqsfsrklllirnnk
 |. |||||..|  .     ..... |      |..... .  ||.||.|.. .|.  . | .|||.|                                
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

nnmlrrlahFQVDGWSNDDITSCN-EGAIINTMNLVKTLQRkSPNSPILMHCSNMIGRSAVFCAAMATVDQmkSSSVVDVFQTVKNMRvnlPgAVQNKGQ
         .|.  .  .| . ..    . ..........  ....|.| |||  .|||....||     .  . |. .... |...|   | .|.| ||
.........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl..glsleeaielvrerR...p.ivpnpgq

YKMIHTLA
.. .. ..
lrqLyefe
0043147 (Phosphotyrosine protein) phosphatases II 303-506 8e-28 92.7 In-house 3-155 (172) alignment 
Range on Protein: 303-506
Range on HMM: 3-155/172.0
ESPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPImegeeeacaqywpkegtiefgeftisvreewghqsfsrkllliRNNKN
|. ||||| ... |   . ||. | |||.|  |||.|. .. ||.||.| .                                             ... 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

NMLRRLAHFQVDGWSNDDITscNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVdqmKSSSVVDVFQTVKNMRvnlPGAVQNKGQYK
.  |   ...  .|   . .  .   ..........|. .||. |.| |||  .||.....||       .. |. .....|...|   ||||||..||.
llerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lglsleeavalvrekR...pgavqnpsqyr

MIHT
 .. 
flyy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 304-423 1.8e-13 44.9 In-house 12-128 (130) alignment 
Range on Protein: 304-423
Range on HMM: 12-128/130.0
SPDYINAVFIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeacaqYWPKEGTIEFGE--FTISVREEWGHQSFSRKLLLIRNNK
  .|||| |.    . . .. .| || .|  |||||...| .  .|.|  . | .|     |||    .|. |   .... .  . .    . | | .. 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleiesdl

NNMLRRLAHFQVDGWSNDDITS
|.  . |. ||.  |  |  | 
neshqaltmfqisnwpsdgttp
0051429 (Phosphotyrosine protein) phosphatases II 305-514 1.8e-32 108.4 In-house 4-227 (272) alignment 
Range on Protein: 305-514
Range on HMM: 4-227/272.0
PDYINAVFIPSYKN---DKGFIIAQSPLRETRRDFWKMiFDREITTIVMLSPIMEGEEEACAQYWP------------KEGTIEFGEFTISVREEWGHQS
..|||| ... | .   .. .. .. ||. | .|||..  .  |.|||.| . .| . . | .|||             . ||..| ... . .|. .  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FSRKLLLIRNN-KNNMLRRLAHFQVDGWSNDDITScneGAIINTMNLVKTlqrkspNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVD--------V
.    ||...  .... |.. |..  .|  . . .    |... ..|. .      . |.|.|||  ..|.....|.   . ..  . .||        .
yilrellltlllsagearevmhlhytdwpdhgvpq...eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNL
...|. .|   |||||. .||....  ...... 
eeaveelraqrpgavqteeqylflyeallellrs
0051082 (Phosphotyrosine protein) phosphatases II 305-505 3.6e-22 74.0 In-house 3-146 (151) alignment 
Range on Protein: 305-505
Range on HMM: 3-146/151.0
PDYINAVFIPSYkndkgFIIAQSPLRetrrDFWKMIFDREITTIVMLSPIMEGEeeACAQYWPKEGtiefgeftisvreewghqsfsrklllirnnknnm
.||||. .. ..     ... . ||     ||.... .  |.|||.| . .| .   |..|.|..|                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

lRRLAHFQVDGWSNDDITSCnegaiINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVdQMksssvVDVFQTVKNMRVNLPGAVQNKGQYKMI
 ... |.....|.. ..  .     ..... .  | .. .| |.|.|||  .||.....|..    ..     |....... .|   ||.|| . |. ..
.ievlhipildwpdpglpls.....fdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfq

H
.
l
0036282 (Phosphotyrosine protein) phosphatases II 306-505 6.9e-34 112.4 In-house 3-163 (174) alignment 
Range on Protein: 306-505
Range on HMM: 3-163/174.0
DYINAVFIPSYKNDKGFIIAQSPLRetrrdFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKegtiefgeftisvreewghqsfsrklllirnNKNNML
||||| ..  .   ...|. | ||.     ||.|...  |||.||| . .| . . | .|||                                ... . 
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

RRLAHFQVDGWSNDDITSCNEgaIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKsSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
|   ...  .|  .   . ..  ... ...|.. . ..|. |.| |||  .||.....||.    ... .|.||....|. .|   ||.||. .||. ..
rlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0049260 (Phosphotyrosine protein) phosphatases II 312-505 1.4e-24 81.9 In-house 1-143 (152) alignment 
Range on Protein: 312-505
Range on HMM: 1-143/152.0
FIPSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWpkegtiefgeftisvreewghqsfsrklllirnnknnmlrrlahf
||. |.. . ||..| |...|  |||.|. .  |||||||   .|  .. |.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QVDGWSNDDITSCNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVdqmKSSSVVDVFQTVKNMRvnlPGAVQNKGQYKMIH
|.  .  .| . ..   ..  ..|.    ..... |.| |||  .||.....||       .  |. .... |...|   ||||.|.||.. ..
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml...lgvsleeavalvrekR...pgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 316-380 2.2e-10 34.5 In-house 232-294 (440) alignment 
Range on Protein: 316-380
Range on HMM: 232-294/440.0
YKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPImegEEEACAQYWPKE-GTIEFGEFTIS
| . . || .| ||  |  |||... | .|.||.||  .   .. .|. ||| .  .. || ||. 
yskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 317-505 1.2e-17 58.8 In-house 2-197 (199) alignment 
Range on Protein: 317-505
Range on HMM: 2-197/199.0
KNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKN--NMLRRLAHFQ
| .. .| .| |||||  |||.|...     |||.       |   . |||    || ..| ......    .  ..   |.. ||       | ..|.|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VDGWSNDDITS--CNEGAIINTMNLVKTLQRkSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS--SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
   | .          | .. . .. |  ..   ..|...|||.  | . || |    |   .   .||||.|.  | .|    | .    .|..|.
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 319-505 1.6e-17 58.4 In-house 3-196 (198) alignment 
Range on Protein: 319-505
Range on HMM: 3-196/198.0
DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVREEWGHQSFSRKLLLIRNNKN--NMLRRLAHFQVD
.. .| .| |||||  |||.|...     |||.       |   . |||    || ..| ......    .  ..   |.. ||       | ..|.|  
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWSNDDITS--CNEGAIINTMNLVKTLQRkSPNSPILMHCSNMIGRSAVFCAAMATVDQMKS--SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
 | .          | .. . .. |  ..   ..|...|||.  | . || |    |   .   .||||.|.  | .|    | .    .|..|.
swkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 326-502 1.7e-12 41.4 In-house 97-278 (302) alignment 
Range on Protein: 326-502
Range on HMM: 97-278/302.0
QSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFT---ISVREEWG----HQSFSRKLLLIRNNKNNMlRRLAH---FQV
  | ..|.  .| .| . ... .| |. ..|.||. ||.|. ..  |...||..|   .||...       .||    . |.|.| .. .       .. 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilaf

DGWSNDDITSCNEgaiiNTMNLVKTLqrKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYK
 .| .       .    ......|    .|    .|.|||. .||.  . |    ..  .   | |. . |. .|    ||||.. |  
sawpdhGapkeay....taldilkfc..esykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_hpo-7_pd Subfamily hpo-7 329-475 6.3e-12 39.9 In-house 43-188 (263) alignment 
Range on Protein: 329-475
Range on HMM: 43-188/263.0
LRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWgHQSFSRKLLLIR--NNkNNMLRRLAHFQVDGWSNDDITSc
| .|   |...|   . ...|||.   | . | | .|.| |  .   . . .... .   ..   . | |.   ..    .. . |..  || .      
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvq.sdvllktlellstlge.KkkthtvkhysykgWiekndpe.

NEGAIintMNLVKtLQRKSpnSPILMHCSNMIGRSAVFCAAMATVDQM----KSS
.   |   .|..| . |.|   .. .|||. ||||| |  |     .|    . .
larei...lnilk.varns..kslvvhcstGiGrsaafsvaElvyqkmirsldtt
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 332-476 2.4e-13 44.7 In-house 40-183 (255) alignment 
Range on Protein: 332-476
Range on HMM: 40-183/255.0
TRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLIRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAI
|   |...|   . ...|||.   | . | | .|.| |  .   . . .... .   .  .    ..    .    . . |..  || .       .  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar.ei

INTMNLVktlqRKSpnSPILMHCSNMIGRSAVFCAAMATVDQ----MKSSS
 | . .|    |.|   ....|||. ||||| |  |     .    .. ..
lnilkvv....rds..ksvvvhCstGiGrsaafvlaelvyqkmirsldtte
0048076 (Phosphotyrosine protein) phosphatases II 398-508 4.3e-12 41.4 In-house 37-139 (145) alignment 
Range on Protein: 398-508
Range on HMM: 37-139/145.0
RNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRKspNSPILMHCSNMIGRSAVFCAAMatvdQMKSSSvVDVFQTVKNMRVNLPGAVQN
 .....  |   ...  .|   .. .     ... ..........  . |.| |||  .||.....||.     |.. . |....... .|   ||||.|
tselellerlgiqylylpwpDhgvpdll.ellleflefieealke..ggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpn

KGQYKMIHTLA
 ||..... . 
pgqlrflyefe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 406-506 3e-13 43.9 In-house 89-188 (440) alignment 
Range on Protein: 406-506
Range on HMM: 89-188/440.0
RRLAHFQVDGWSNDDITSCnEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
| | ... .|| .  .     | ... .. |.  | |. |.|.|.|||   ||..|  |  . . . | |  .|.|  ...|| | |  ||   || ..|
rtlkqyhyqgwpdkgvpkf.agpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

T
 
e
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 407-512 1.4e-13 45.0 In-house 279-385 (392) alignment 
Range on Protein: 407-512
Range on HMM: 279-385/392.0
RLAHFQVDGWSNDDITsCNEG--AIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMI
 .. .|  ||        . |  ...  .  ||.   .  .  ||.||    ||. |||.||  . |.     ||.||||| .| .    || . .| ..
tvtqyqfhgwpkhgsd.qqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafv

HTLAAAYV
. .   |.
ydvireyl
PTPc_DSPc_SM00012 409-508 1.1e-20 69.2 In-house 3-103 (105) alignment 
Range on Protein: 409-508
Range on HMM: 3-103/105.0
AHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRKSP-NSPILMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
 |... ||..  . .    .|..... ||. ..||  ..|.. |||. .||...|.|.   ..|.... . ||.||.|| .|   ||.||.. || ....
khyhytgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LA
  
al
0048179 (Phosphotyrosine protein) phosphatases II 410-507 9.4e-12 40.4 In-house 51-140 (144) alignment 
Range on Protein: 410-507
Range on HMM: 51-140/144.0
HFQVDGWsnDDITSCNE-GAIINTMNLVKTLQRksPNSPILMHCSNMIGRSAVFCAAMatvdQMKSSSvVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
...  .|  .|    .    .............  .. |.| |||  .||.....||      ||    ........ .|   ||||.| ||..... .
qylhlpw..pDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLley
0038934 (Phosphotyrosine protein) phosphatases II 418-506 4.7e-06 21.9 In-house 88-171 (194) alignment 
Range on Protein: 418-506
Range on HMM: 88-171/194.0
NDDITSCNEGAIINTMNLVKTLQRKSPNSPILMHCSNMIGRSAVFCA-AMATVDQMkssSVVDVFQTVKNMRvnlPGAVQNKGQYKMIHT
 ||.|. .   . . ..||..  ...|.  .. ||   .||.....| ..  . .|   |. .  .... .|   |||..| ........
pddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm...saeeAialfrekR...pgaipnqdyleallk
subfamily_CG42327_pd Subfamily CG42327 440-512 5.2e-10 33.5 In-house 242-315 (319) alignment 
Range on Protein: 440-512
Range on HMM: 242-315/319.0
QRKSPNSPILMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
 ... . |. .|||. .||. .  |.  .. ... |   ||. |.|  .| .   ||..| ||..|.  .  | 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 449-506 2.8e-10 34.4 In-house 2-59 (69) alignment 
Range on Protein: 449-506
Range on HMM: 2-59/69.0
LMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
..|||   ||.  | | |  . ..||  .||.|  |. ||   |  | |. .| .|| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihd
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 450-506 3.1e-10 34.2 In-house 2-58 (69) alignment 
Range on Protein: 450-506
Range on HMM: 2-58/69.0
MHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
.|||   ||.  | | |  . ..||  .||.|  |. ||   |  | |. .| .|| 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihd