Gene PTPRD-39 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP094_AA protein Get Run
AqueP094_AA_120-398 phosphatase_domain Get Run
AqueP094_AA_410-673 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 6-45 5e-06 19.7 Pfam-A 46-85 (85) alignment 
Range on Protein: 6-45
Range on HMM: 46-85/85.0
SITYNVNSTNTHIILNDLLFSTVYNISVAAVNSVGRGPFS
. ...| .| |. .|..|  .| |...|.||| .| ||.|
wkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 65-150 4.6e-06 19.9 Pfam-A 11-84 (85) alignment 
Range on Protein: 65-150
Range on HMM: 11-84/85.0
ImDATWSVISWSVPSfiPQDYPIITFEIGYLSDNCSIidvddiddeALDQYNVSSGNRYANITGLNHTSCYIFGVRAYTDNGYGEW
.  .|  ..||| |.  ... ||  .|. | ... .          .  ...|..  . ...|||.  . | | |.|....|.|..
v.tstsltlsWsppk..dgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 104-397 2.2e-60 199.2 In-house 29-276 (281) alignment 
Range on Protein: 104-397
Range on HMM: 29-276/281.0
VDDIDDEALDQYNVsSGNRYANITGLNHTSCYIFGVRAYTdngygewifitnktlshqpsasvaptldddnriiltanpdldmcQREFINANYVDGYSRS
||.    .  . ||   ||| ||.  ..|   .    . .                                            . ..||||.|.||.  
vdntataskadenv.lknrYsnivaYDatrvkvtpneenk............................................ntDYinanfvpgykge

KKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAItEQEKFGPFIVLLKNTQAYSDFVTRQLCItiQDGSNDSHTLTQYHLTTW
|.|..||||. ..||.|| ..|...   |||.|.  |.|| || .|||.   .. |.| ..|  ..... . ...|.. .  .  |... ...| . |.|
keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.selkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaW

PDQGVPDYATSLMTLYKRVMNTWSPSQ-GPILVHCSAGIGRTGIFIAIDLALEQAKKE-GVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEI
||.|||. .. |.   | |... ....  |...|||||.|||| .||.| .......|   .|   ... ||..|. |||.. || |.. || . .
PdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 116-393 1.2e-24 81.7 In-house 46-340 (350) alignment 
Range on Protein: 116-393
Range on HMM: 46-340/350.0
NVSSGNRYANITGLNHTSCYIF-GVRAYtdngygewifitnktlshqpsasvaptldddnriiltA---------NpdldmcqreFINANYVDGY-----
.. . ||| ||   .|.   .  ....                                                .         .|||||.        
elfaknrYknilPYehsrvkLkkslkss.....................................dakkhslstnD.........YinanYlkltrfsve

-SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQ---------------EKFGPFIVLLKNTQA-------YSDFV
   . ||. ||.|...|. ||. .| .     |..||.. | .  || .||..   ..               ..   . . .|.. .         |  
inpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlk

TRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYK---RVMNT------WS-PSQGPILVHCSAGIGRTGIFIAIDLALE------QAKK-E
  .  . |.  . | . . | ..  |.| ..     |...  .    ....           . |||||||||.||||.....|  |.      . .|  
dnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkes

GVIDF--------AGIINRLRQQRMKMVQSLDQYVFLHDAV
  .|           |.|.||.||..|||.|||..|...|.
rkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
0045098 (Phosphotyrosine protein) phosphatases II 121-400 7.6e-67 220.9 In-house 37-275 (278) alignment 
Range on Protein: 121-400
Range on HMM: 37-275/278.0
NRYANITGLNHTSCYifgvraytdngygewifitnktlshqpsasvaptldddnriiltanpdldmcqrEFINANYVDGYsrSKKYVTTQGPMKNTLVDF
||| .|  ..|.  .                                                      ..|||.|.|||  .||.. ||||...|. ||
nRykdilpydhsrVk......................................................dYINAsyidgy..pkkfIatqgPlpstvadf

WYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiTEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQ---DGSNDSHTLTQYHLTTWPDQGVPDYA--TSL
| ..|...  .|||||.|.|.|. || ||||.   . . .|.| | |.... ..|...| | .|     . .. |...|..|...||| |||..   .|.
wrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf

MTLYKRVMNTWS-------------PSQGPILVHCSAGIGRTGIFIAIDLALEQAkkEGVIDFAGIINRLRQQRMK-MVQSLDQYVFLHDAVFEEIICG
  |.... .  .             .|.||.|||||||.|||| ..|..| ||.   ||..|.  ... ||.||.  .||.|.||.||.... | . .|
lellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 125-419 1.3e-135 446.4 In-house 2-305 (305) alignment 
Range on Protein: 125-419
Range on HMM: 2-305/305.0
NITGLNHTSCYIFGVRAYTDNGY----------GEWIFITNKTLSHQPSASVAPTLDDDNRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMK
.|..|.....||...|.|.|.|.          .|.|....|. ... ......||.||.|||||....||  ....|||.|||||.|.|||...|||.|
kiialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

NTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATS
||..|||.||..|....|||||||.||||.|||||||...||...||.|.| ||.....||...|.|.|.|.|....|.|..||.||.|||.|||..|||
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LMTLYKRVMNTWSPSQG-PILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEI
|..|.|||..... ..| |.|||||||.||||.|||.|.|||..|||.|.|.......||..||||||.||||||||||. |.|.||.|.|...|.....
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKLKKN
.||||.
nklkkm
0045450 (Phosphotyrosine protein) phosphatases II 153-395 5.1e-73 241.8 In-house 67-302 (307) alignment 
Range on Protein: 153-395
Range on HMM: 67-302/307.0
ItnktlshqpsasvaptldDDNRIILTANPDLdMCQREFINANYV--------DGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKS
                   |..|..|.  ..  .    .|||.||        ||| ...|.. ||||...|. ||| ..|...   |||||.|.| |. 
y..................dhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

KCRQYWPNAiTEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMN--TWSPSQGPILVHCSAGIG
|| ||||.   |.  .|.| | |.... ..... |.|..|  ||.. |.|.|..| |.|||.|||..  .|  ....|..   ..|..||.|||||||.|
kcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGIFIAIDLALEQAKKEGV---IDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFE
||| |||..|.|.| .|||.   .|.  ....||.||...||...||.||..|..|
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0049772 (Phosphotyrosine protein) phosphatases II 163-393 1.1e-34 116.0 In-house 49-276 (314) alignment 
Range on Protein: 163-393
Range on HMM: 49-276/314.0
SASVAPTLDDDNRIILtanPDLDMCQREFINANYVDGYsrsKKYVTTQGPMKNTLVDF----------WYLI--WQERPVSIVM----------------
  .    |  ||| ||   | |..    .|||.||||.   .|.. ||||...|.|||          | ..  .. ..  |||                
knryldilpadnrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaA

-----LTKLKEGGkskcRQYWPNAITEQEkfgpfivllkntqaysdfvtrqlciTIQDGSND-SHTLTQYHLTTWPDqGVPDYATSLMTLYKRVMNTwsP
     |..| ..|     ....  . . .                         ....  .. ...  .|. . .|| | ..    .  ... . .   .
lgKtpllildgng....neptaadlellk.........................eelydpelferlgikylripvpD.gsaplledfdeflefieea..d

SQGPILVHCSAGIGRTGIFIAIDLALEQAkkeGViDFAGIINRLRQQRM-----KMVQSLDQYVFLHDAV
 .||.||||.||.|||| |..... . .    || ... .....|..|.      ....|.||.| ..|.
kggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefileal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 165-394 6.2e-48 158.0 In-house 46-274 (287) alignment 
Range on Protein: 165-394
Range on HMM: 46-274/287.0
SVAPTldDDNRIILTANPDLDMcqrEFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFI
 | |   ||.|..|.|...|     ..|||||| .| . ......|||.  |. ||| .....|  |....|.  | .. || .|||.        |  .
dvlPi..ddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysv

VLLKNTQAYSDFVTRQLCITIQDGsNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRV-----MNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKK
|||. ..   .. .| | .   .. .... . |..| .|||....  | .|. .   |     ..  .   ||..||...||||.||..|.   ... ..
vlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrled

EGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVF
 | .| | .. |||..|  .||.  |. .| .|. 
lGrvdvaavvirlreyraalvqavvqlrllyealv
0043336 (Phosphotyrosine protein) phosphatases II 168-395 4.2e-72 238.3 In-house 54-275 (278) alignment 
Range on Protein: 168-395
Range on HMM: 54-275/278.0
PTLDDDNRIILTANPDldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPnaiTEQEKFGPFIVLL
  . | .|..|.  .        .|||.|||||....|.. ||||...|. ||| ..|...  .|||||.|.| |. || ||||    . ...|.| | |
ilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtl

KNTQAYSDFVTRQLCITIqDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
.... ..|...|.|..|   |.. |.| |.|| . |||.|||.  ..|. ..|.|..  ..|.||.|||||||.|||| |||..|.|||..||| .|.  
lkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdlee

IINRLRQQRMKMVQSLDQYVFLHDAVFE
....||.||...||...||.||..|..|
avkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 169-399 1.4e-93 307.9 In-house 50-295 (301) alignment 
Range on Protein: 169-399
Range on HMM: 50-295/301.0
TLDDDNRIILTANPDLDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLK
|  |||||||. .|.||.||||.|||.|.||||..||.. .|||||.|||||| |||||.||||||.|.|||| ||||.|||||. .|.|.|||| |.|.
tvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlv

NTQAYSDFVTRQLCITIQDGSN--------------DSHTLTQYHLTTWPDQGV-PDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLA
|.|.| ||| |||...||||||              .|....|...| ||..|| ....| |. . . .. ..... ||..||||....|.|........
neqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsig

LEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIIC
|||.| |||.|  ......|......|. |.||....|.. . . .
lEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
0039614 (Phosphotyrosine protein) phosphatases II 169-401 2.7e-73 242.4 In-house 66-293 (297) alignment 
Range on Protein: 169-401
Range on HMM: 66-293/297.0
TLDDDNRIILTANPDLDMcQREFINANYVDGYSR-SKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKsKCRQYWPNAITeqeKFGPFIVLL
   |..|..|. ... |.    .|||.|||||.. ..|.. ||||...|. ||| ..|...  .|||||||.| |. || ||||.  .   ..|.| | |
lpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtl

KNTQAYSDFVTRQLCITIqdgSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWS--PSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDF
.... ......|.|..|    .. |.|.|... | ||| |||.....|. ... |..  .  |..||.|||||||.|||| |||..|.||| .||| .|.
lkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdv

AGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGK
  ....||.||...||...||.||.||..| . ...
leavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 170-396 3.4e-78 257.5 In-house 57-282 (290) alignment 
Range on Protein: 170-396
Range on HMM: 57-282/290.0
LDDDNRIILTANPDLDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQekFGPFIVLLKN
. |||||.|   ..   |. |.||| |..||. .|.|. ||||..||||||| |||||.   |||||. .| || ||.||||.. |..  .|.| . | |
vyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsiklln

TQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQG-VPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGI
 ........|.| .. .. .......|||..|.|...| |....|.|....... . . . ...|.||||...||...|.|.. .....|.|||||   .
eetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqv

INRLRQQRMKMVQSLDQYVFLHDAVFEE
....|.|....||. .|| .... |.. 
lksqRiqkpgsvqtvqqyqgifqivlty
0040439 (Phosphotyrosine protein) phosphatases II 170-395 7.7e-68 224.1 In-house 22-244 (249) alignment 
Range on Protein: 170-395
Range on HMM: 22-244/249.0
LDDDNRIILTANPDLDMCQreFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiTEQEKFGPFIVLLKN
  | .|..|.  |.|  .   .|||.|.||| ...... ||||...|. ||| ..|...  .|||||.|.| |. || ||||.   .  ..| | | |..
pydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtlls

TQAYSDFVTRQLCITIQdGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMN--TWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
.. ..|...|.|..|   . ..|.| .... | |||.|||..  .|. ....|..  .. |..||.|||||||.||||.|||..|.||| .||. .|.  
vevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdlee

IINRLRQQRMKMVQSLDQYVFLHDAVFE
... ||.||...||...||.||..|..|
avkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 170-395 6.1e-66 217.6 In-house 20-241 (245) alignment 
Range on Protein: 170-395
Range on HMM: 20-241/245.0
LDDDNRIILTANPDLDMCQreFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiTEQEKFGPFIVLLKN
. |..|..|.  .    .   .|||.||||| ...|.  ||||...|. ||| ..|...  .|||||.. | |. || ||||.   |  ..| |.| |..
pydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtlls

TQAYSDFVTRQLCITIqDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWS-PSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGI
.. ..|...|.|..|  .|.. |.. ..|| . |||.||||.  .|  ....| .  . .|.||.|||||||.|||| |||..|.|||..||. ...  .
eehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleea

INRLRQQRMKMVQSLDQYVFLHDAVFE
. .||.||...||...||.||..|..|
vkelrsqRpgavqtpsqyrflyealle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 170-395 1.3e-44 147.0 In-house 67-281 (290) alignment 
Range on Protein: 170-395
Range on HMM: 67-281/290.0
LDDDNRIILTanpdlDMCQREFINANYVDGYSrsKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKN
 .|  |.||      |  . ... ||||.|      .. |||..|.| .|.| .. ||.   |||| .| | ||.|| ||.|.   |   || . ||  .
cndktrvilk.....dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcse

TQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMtlykRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGII
 .   . . ...    .  |  .| |  ... .|||. |.  . .|.    |.. .     ||. ||||||||||| |.||. .|.   .   .| ....
eddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall....rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlv

NRLRQQRMKMVQSLDQYVFLHDAVFE
  ||. |.. ||   ||. | .....
ralrnsrlnsvqvdiqylalveilld
0036941 (Phosphotyrosine protein) phosphatases II 171-411 8.7e-80 263.5 In-house 51-291 (297) alignment 
Range on Protein: 171-411
Range on HMM: 51-291/297.0
DDDNRIILtanpdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNT
 |..|..|      |     .|||.|||||....|.. ||||..||. ||| ..|...  .|||||.| | |. || ||||. . |  ..|.|.| |...
ydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsv

QA--YSDFVTRQLCITIQdGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMN--TWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAK---KEGVI
.   ..|...|.|..|   |...|.|.|..| |.||| |||....||. ....| .    .||.||.|||||||.||.| |||.||.|.| .   ||| .
evvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggv

DFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTV
|.  ... ||.||. .||.|.||.||..|..| . ...|.. . .. .
dileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
0051299 (Phosphotyrosine protein) phosphatases II 171-396 2.1e-79 262.3 In-house 61-285 (288) alignment 
Range on Protein: 171-396
Range on HMM: 61-285/288.0
DDDNRIILTANPDldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiTEQEKFGPFIVLLKNT
 |..|..|.  ..  .    .|||.|.||| ...|.. ||||..||. ||| ..|...   ||||||| | |. || ||||.   . ...|.. | |...
ydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllse

QAYSDFVTRQLCITIQD---GSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
. ..|...|.|..|  |   |.. |.| |..| |.|||.||||....|......|..  ....||..||||||.|||| |||.||.||| .|||..|. .
evlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle

IINRLRQQRMKMVQSLDQYVFLHDAVFEE
...|||.||. |||...||.|...|..| 
avkrlreqRpgmvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 171-416 3.7e-78 258.3 In-house 55-295 (317) alignment 
Range on Protein: 171-416
Range on HMM: 55-295/317.0
DDDNRIILTANPDldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiTEQEKFGPFIVLLKNT
 |..|..|.  .        .|||.||||.....|.. ||||..||. ||| ..|...  .|||||.|.| |. || ||||.   |  ..|.|.| |...
ydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllse

QAYSDFVTRQLCITIQdGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
. ..... |.|...   |...|.|.|..| |.|||.|||.. ..|  . ..| .  ....||.|||||||.|||| |||..|.||| .||| .|.  ...
eelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavk

RLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKL
.||.||...||...||.||.||..| . .. |.. . .. ....||
elreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 171-403 7.4e-77 253.1 In-house 59-284 (287) alignment 
Range on Protein: 171-403
Range on HMM: 59-284/287.0
DDDNRIILTanpdldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITeqEKFGPFIVLLKNT
 |..|..|        .. ..||| ..|||. .|... ...|| ||...|| ||.....  ||||...||  ...| ||||.  .    .|.. . | | 
pdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellne

QAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQG-VPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGII
. ..... |.| .. .. ..| ....||..|.|...| |....|.|. . ... .   .....|.||||...||...|.|.. .....|.|||||   ..
evnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvl

NRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTD
.. |.|....||  .|| |. |.| | . ...| 
ksqriqkpgsvqtveqykfindivleyldsfety
0047943 (Phosphotyrosine protein) phosphatases II 171-395 1.2e-75 249.8 In-house 50-270 (273) alignment 
Range on Protein: 171-395
Range on HMM: 50-270/273.0
DDDNRIILtanpdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITE-QEKFGPFIVLLKN
 |..|..|      ..    .|||.||||| ...|.. ||||..||. ||| ..|...   |||||.| | |. || ||||.   |  ...|.|.| |..
ydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtlls

TQAYSDFVTRQLCITIQDGSNdSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSP--SQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
.. ..|...|.|..|  . .. |.| |..| |.|||.|||.. .||..... |... .   |.||..||||||.|||| |||.||.|.| .||| .|.  
eetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvle

IINRLRQQRMKMVQSLDQYVFLHDAVFE
....||.||. |||...||.||..|..|
avkllrsqRpgmvqtpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 171-395 1.9e-72 238.8 Pfam-A 13-235 (235) alignment 
Range on Protein: 171-395
Range on HMM: 13-235/235.0
DDDNRIILTANPD-LDmcqreFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLK-
 |..|. |. ...  |     .||||||.||...||.. ||||.|.|. ||| ..|||.  .|||||.|.| |. || ||||..  |....| . | || 
ydktrvklkgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelke

NTQ-AYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
... . .....|.| .. ...........|.|.|.|||.|||. ..||. | ..| .. ....||..||||||.||||.|.|.|..|||...|. .|   
kekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlq

IINRLRQQRMKMVQSLDQYVFLHDAVFE
|...||.||..|||||.||.||..|..|
ivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 171-395 1.9e-72 238.8 In-house 13-235 (235) alignment 
Range on Protein: 171-395
Range on HMM: 13-235/235.0
DDDNRIILTANPD-LDmcqreFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLK-
 |..|. |. ...  |     .||||||.||...||.. ||||.|.|. ||| ..|||.  .|||||.|.| |. || ||||..  |....| . | || 
ydktrvklkgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelke

NTQ-AYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
... . .....|.| .. ...........|.|.|.|||.|||. ..||. | ..| .. ....||..||||||.||||.|.|.|..|||...|. .|   
kekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlq

IINRLRQQRMKMVQSLDQYVFLHDAVFE
|...||.||..|||||.||.||..|..|
ivkelRkqRpgmvqsleqYiflykaile
0037934 (Phosphotyrosine protein) phosphatases II 171-395 2.6e-61 202.6 In-house 22-240 (243) alignment 
Range on Protein: 171-395
Range on HMM: 22-240/243.0
DDDNRIILtanPDldmcqREFINANYVDGYsrsKKYVTTQGPMKNTLVD----FWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPnaitEQEKFGPFIVL
 |..|..|   ..       .||||.....   ...  ||||...|. |    || ..|...  .|||||.|.| |. || ||||    ... .|.|.| 
ydhsrvkl...eg.....sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gevtygdftvt

LKNTQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNT--------WSPSQGPILVHCSAGIGRTGIFIAIDLALEQAk
|.... ..|.. | |...  | .. ... ..|| . |||.||||  ..|. . . | .           .|.||.|||||||.|||| .||..| |..  
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.

keGvIDFAGIINRLRQQRMK-MVQSLDQYVFLHDAVFE
  | .|.  ....||.||.  .||...||.||..|. |
..g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN23_pd Subfamily PTPN23 171-396 3.8e-51 168.6 In-house 55-279 (288) alignment 
Range on Protein: 171-396
Range on HMM: 55-279/288.0
DDDNRIILTanpdldMCQREFINANYVDGY-SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKN
.| ||. |         . ..||| .| .  . . ....||.|...|| ||| ......   ||||.. .| || |. .|||..  | .|||.. | ||.
yDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlks

TQAYSDFVTRQLCITIQDGSnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMN----TWSPSQGPILVHCSAGIGRTGIFIAIDLALEQ-AKKEGVID
..  . .| |.| ....| .   ....  .||.||. |||.   .|. . . | .    .  .|. |..||||||.||||.|  .  |...  |..|..|
vretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglld

FAGIINRLRQQRMKMVQSLDQYVFLHDAVFEE
   ...|||.||  |||  .|. |. .|| |.
iiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRD_pd Subfamily PTPRD 172-524 1.1e-120 398.9 In-house 61-413 (564) alignment 
Range on Protein: 172-524
Range on HMM: 61-413/564.0
DDNRIILTANPDLdmCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAiTeQEKFGPFIVLLKNTQ
| .|..|.. .     . ..|||...||| ..|.|. ||||...|. ||| ..|...  .|||||||.| || || .|||.  . .|..| ..| |....
dhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee

AYSDFVTRQLCItIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINR
 ..|.. |.. .  .  |..|.. .|.| | |||.|||..||||..| ..| ....| .|||.||||||.||||.||.||  ||..|.|...|  .....
eladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvka

LRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQYHLLCELTP-DPNDVECKSANAHSNKNRSNNYLPPDKYII
||.||  |||. .||.|.|.|. | . ||.|.. .||.. ..|||.. ..  . ||.|. .. |   .. ....  .   .  ..|||  | |. ..  .
lrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrv

TLKDT----NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC
.|.      . ||||||||..|..|. || .|.|..||| .||.|... .| .||||.
vlsairakeesdyinasyleayrekrafiatqaplkntvedfwrmvweeevkiivmlt
0050432 (Phosphotyrosine protein) phosphatases II 172-402 7.9e-79 260.5 In-house 81-304 (308) alignment 
Range on Protein: 172-402
Range on HMM: 81-304/308.0
DDNRIILtanpdlDmCQREFINANYVDGY--SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAIT-EQEKFGPFIVLLK
| .|..|      |     .|||.|||||   ...|.. ||||..||. ||| ..|...   ||||||| | |. || ||||. .  . ...|.| | |.
dhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtll

NTQAYSDFVTRQLCITIQDGSnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWspSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGI
... ..|...|.|..|  ... .|.|.|..| |.|||.|||.....|......| ..   ..|||.||||||.|||| |||.||.||| .||| .|. ..
seevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfea

INRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKT
...||.||. |||...||.||..|..| . . .|
vkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 172-432 1.9e-78 258.8 In-house 61-318 (319) alignment 
Range on Protein: 172-432
Range on HMM: 61-318/319.0
DDNRIILTANPDldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAitEQEKFGPFIVLLKNTQ
|  |..|.. ..  . . ..|||...||| . .|.. ||.|..||. ||| ..|.|.   .||||||.| .| |...|||..  . |..| .|| |.. .
drtrvvlseldg..vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeee

AYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSP-SQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
  .|.. |.|.. .. .  .. ...... | |||..||..||||. |.||. ....  ..||| ||||||.|||| ||..| .||. |.|||.|   ...
eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvs

RLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQY
||| ||  |||  .|| |...|. | . .|.|.| ...    ...|.....    ||.| ..
rlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
0046845 (Phosphotyrosine protein) phosphatases II 172-402 9.4e-78 256.7 In-house 41-279 (284) alignment 
Range on Protein: 172-402
Range on HMM: 41-279/284.0
DDNRIILTANPDlDMCQREFINANYVDGY-----SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAiTEQEKFGPFIVL
|..|..|.  .. |.   ..|||.|||||      ..||.. ||||..||. ||| ..|...   |||||.| | |. || ||||.   |  ..|.|.| 
dhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvt

LKNTQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWS--PSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEG---
|.... ..|...| |..|  . .. |.|.|..| |.|||.|||.....|..... | .  .  |..|||.||||||.|||| |||.||.||| .|||   
llseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglll

VIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKT
..|. ....|||.||. |||.|.||.|...|..| . ...|
gvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 172-433 1.4e-77 255.9 In-house 59-316 (318) alignment 
Range on Protein: 172-433
Range on HMM: 59-316/318.0
DDNRIILTANPDldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAitEQEKFGPFIVLLKNTQ
|. |. |.   .    . ..|||||.||| |.|.|. .|.|. .|. ||| ..|.     |||||...| || |. .|||.   . ...|   | ||.. 
dhtrvkLqmleg..eegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeev

AYSDFVTRQLCITIqDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTW-SPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
 .||.| |.. .|  .....| .  ||| |.|||.|||. ..||. | ..| ..  ....|||.||||||.||||.|||.|  ||..|.|...|  ....
elsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvk

RLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQYH
.||.||  |||  |||.|..|.. | ...|.|..  .. . .|..|...|| .  | ..|...
qlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
DSPc_SM00195 172-397 2.8e-74 245.1 In-house 39-262 (263) alignment 
Range on Protein: 172-397
Range on HMM: 39-262/263.0
DDNRIILTANPDLdmCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQ
|..|..|. ...    . ..|||||..|....|||. ||||...|. ||| ..|.|.   |||||. .| || || .|||. . ..|.|| . | |....
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

AYS-DFVTRQLCITIQDGsNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
 .. ....|.| .| ..  ......|||. ..|||.|||| ..|.. |.. | .. | |.|||.||||||.||||.|..||..|.. ..|  .|.  |..
kkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

RLRQQRMKMVQSLDQYVFLHDAVFEEI
.||.||..|||.|.|| |...|. | |
elRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 172-397 2.8e-74 245.1 In-house 39-262 (263) alignment 
Range on Protein: 172-397
Range on HMM: 39-262/263.0
DDNRIILTANPDLdmCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQ
|..|..|. ...    . ..|||||..|....|||. ||||...|. ||| ..|.|.   |||||. .| || || .|||. . ..|.|| . | |....
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

AYS-DFVTRQLCITIQDGsNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
 .. ....|.| .| ..  ......|||. ..|||.|||| ..|.. |.. | .. | |.|||.||||||.||||.|..||..|.. ..|  .|.  |..
kkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

RLRQQRMKMVQSLDQYVFLHDAVFEEI
.||.||..|||.|.|| |...|. | |
elRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 172-404 4e-70 231.4 In-house 69-297 (298) alignment 
Range on Protein: 172-404
Range on HMM: 69-297/298.0
DDNRIILTANPdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAitEQEKFGPFIVLLKNTQ
|  |..|...   .  . ..||| ....|.... ...||.|...|..||| ....|   .|||||.|.| .| |. .|||.   ..|..| . | |....
dssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllske

AYSDFVTRQLCITIQDGSnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNtWSPSQG--PILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGII
 ..|...|.| .. .. . ..... | | |.|||.||| .|||...| ..|   .    |  |..|.||||.||.| |||||  ||..||| |.|   ..
efadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvv

NRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDI
..||..|...||. .||||...|| | . .....|
kvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Ptp69D_pd Subfamily Ptp69D 172-416 6.4e-69 227.4 In-house 61-305 (307) alignment 
Range on Protein: 172-416
Range on HMM: 61-305/307.0
DDNRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAitEQEKFGPFIVLLKNTQ
|..|..|.  .  .  . ..|||... ||  .||... |.|. .|. ||| .|..     ||||..|.|  . || .|||.   .. ..|  .| | ...
DktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvsee

AYSDFVTRQLCITIQD----GSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAG
  ||.. |.| .. ..      .||. ..||| |.|.|  ||. |..|. | ..| .  . ...||.|||||| ||.|||.|.|. |.| |.|  .|   
khsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife

IINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKL
..  ||.||  .||||.|||||. |. . .  |.||. ....  .|..|
tvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_PTPRA_pd Subfamily PTPRA 172-431 8.8e-69 226.9 In-house 71-329 (330) alignment 
Range on Protein: 172-431
Range on HMM: 71-329/330.0
DDNRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAitEQEKFGPFIVLLKNTQ
| .|.||.     .  . ..||| ..||| . .|....||| ..|. ||| .||. .  .|||||.|||  ..|| ||||.       .|   | .....
dfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedet

AYSDFVTRQLCIT-IQDGS--NDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGI
   |.  |..... . |..  ..|  ..|.|.|.||| |||  .  .. | |.| ..   | ||| ||||||.|||| ||..|  ||. | |...|  ..
vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfef

INRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQ
..|||.|| .|||.. ||.|.. .. |  . | |.. .      .|||... .... .|.| .
vkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleee
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 172-418 9.2e-68 223.4 In-house 57-298 (315) alignment 
Range on Protein: 172-418
Range on HMM: 57-298/315.0
DDNRIILTANPdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQ
| .|..|      |  ....||| |. ..   | |...||| | .. ||| ...||.. .|||.||..|| | |||||||.  ..  .|| . | | ...
dsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsle

AYSDFVTRQLcitIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINR
| .| |.|.|   .   |..|.|.||...| |||.||.  ..||. | | |     . . ..|||||||.||||..|.||  ..|.|.. ..|   ... 
adtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvkn

LRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKK
||..|...||. ..| |..||| |..   .| ||. ..|  .| |. 
lrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 172-406 1e-66 219.7 In-house 22-245 (250) alignment 
Range on Protein: 172-406
Range on HMM: 22-245/250.0
DDNRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSkCRQYWPnaITEQEKFGPFIVLLKNTQ
|  |..|  .   .  . ..||| ...||. .| ...||||...|..||| ....|   .|||||.||| .|  . ||||  . . ||.|   | |....
dssrvvLekekgdk..esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..vekaekyGdvtvsllske

AYSDFVTRQLCITIQDGsNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSP-SQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
 ..|...|.| .. .   .|. .. |.| ..|||.|||..||. . | |.|  .     ..|..|.||||.||.| |||||  ||..||| |.|   .|.
efadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvik

RLRQQRMKMVQSLDQYVFLHDAVFEEIICgktdilI
.||..|...|.||.||||.. .. . . .      .
vlrkdrphavesleqyvfvyeiilkalds......v
subfamily_PTPRG_pd Subfamily PTPRG 172-418 1.6e-66 219.7 In-house 60-304 (563) alignment 
Range on Protein: 172-418
Range on HMM: 60-304/563.0
DDNRIILTANPDLDMCQrEFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiTEQEKFGPFIVLLKNTQ
|  |. |.  |. .    ..|||||.||| .||....||||.|.|. ||| .||...   |||.|.|.| |. || .|||.   | |..| . | |....
drsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieee

AYSDFVTRQLCITI---QDG--SNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFA
  .   .|.| |     ...   .. .. .||| |.|||.|||....  ..  |.   .     |||.||||||.||||..|..|  |.| ..| ...  
vlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvf

GIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIEnytvEIQKLKK
|.. ..| ||  .||. .||.|||||. | |  ..|..| |    ....||.
gflkhiraqRnflvqteEqYiflhdalleaiasketellae....qveelkn
subfamily_PTPN12_pd Subfamily PTPN12 172-395 1.8e-62 205.8 In-house 53-275 (290) alignment 
Range on Protein: 172-395
Range on HMM: 53-275/290.0
DDNRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQ
| .|. |. . . .  . ..||||.. | . ...|. .|||. .|| ||| .||. .   .||. .. | || ||..|||.   |. .||.| | |.. .
dksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

AYS-DFVTRQLCITIQdgsNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGV---IDFAG
| . ||. |.| .. |   ..|....|.| | |||.|||  |.||. | . | .. . .. |..||||||.||||. ||||.. |. |.| .   .|   
avdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfd

IINRLRQQRMKMVQSLDQYVFLHDAVFE
.. .||.||  .||. .||.... || |
lvlelrkqraalvqtkeqyelvykavae
subfamily_PTPN6_pd Subfamily PTPN6 172-394 7.6e-61 200.7 In-house 67-294 (306) alignment 
Range on Protein: 172-394
Range on HMM: 67-294/306.0
DDNRIILTanpDLDMCQREFINANYVDGYSR--SKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEkFGPFIVLLKN
|..|.||.   . .. . ..|||||... ..  .|.|..||| ...|. ||| ..|||    |||.||  | ||.|| .|||.. ...| .|   |   .
Dhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvs

TQAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQ----GPILVHCSAGIGRTGIFIAIDLALEQAKKEGV---
 .. .|.. |.| .. .. ....... ||| ..|||.|||     .. . . | .  . ..    |||.||||||||||| || ||. |.. .|.|.   
eksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

IDFAGIINRLRQQRMKMVQSLDQYVFLHDAVF
||   ... .|.||  .||  .|| |.. |. 
idiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPN9_pd Subfamily PTPN9 172-395 8.5e-61 200.6 In-house 55-288 (297) alignment 
Range on Protein: 172-395
Range on HMM: 55-288/297.0
DDNRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQ
|. |. |.  .. .  . ..||||.|||| . | ...||||.|.|  ||| ..|... . ||| |.. | |. ||.||||.   ....|| . |   ...
detrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve

AYSDFVTRQLCITIQDgSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNT-------------WSPSQGPILVHCSAGIGRTGIFIAIDLALEQAK
 ..|...|.| |.  .  ..| ..| . ...||| |||. |.||. . . | ..               ||. ||.||||||||||| ||..|..|.. .
eeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle

KEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFE
..|..|    ...||.||  ..|  .||.| . || |
evgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 172-432 1.8e-59 196.5 In-house 61-323 (325) alignment 
Range on Protein: 172-432
Range on HMM: 61-323/325.0
DDNRIILTANPDldMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLI--WQerpVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKN
| .|..| .  |    . ..|||.|.  . . . ....| |. .|. |.| |.  |.    |.|...   ..|| .| .|||. . .  .||.. | |. 
dksrvvletkkd..dpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrt

TQAYSDFVTRQLCITIQDGSnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRV------MNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVI
 . .||.| |.| .   ..  .. .. |..| .|.| ||. . ..|... . |      ... . . .|||||||||.||||.||..  ||..  .|  .
ieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrv

DFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQY
|  | ...||..| .||.. |||.....|. | ...|.||. . ..  ..  |.. .|  .   || ..
difgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekef
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 172-408 2.7e-59 195.7 In-house 64-295 (297) alignment 
Range on Protein: 172-408
Range on HMM: 64-295/297.0
DDNRIILTANPDldMCQREFINANYVDGYSRskKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKsKCRQYWPNAITEQekFGPFIVLLKNTQ
| .|..|    |    . ...|| .| |.    ...||| |||.|. ||| ....|..  ||||....|. | ||..||..  . .  ||   |.|. ..
dssRvkLaivnd..dpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvs

AYSDFVTRQLCITiQDGSNDSHTLTQYHLTTWPDQGVPD--YATSLMTLYKRVMNTWSPSQG-PILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGI
  . |. |.| .| .. .   . . ||. . |||. |.    |.||. | . | ...|  .  |.||||.||.||||....||  . .||.|  .|  |.
ereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifgl

INRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIEN
...|||.|...||  .|| |.. || | ... .|.| .. 
vkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_CG7180_pd Subfamily CG7180 172-402 7.5e-54 177.4 In-house 55-295 (296) alignment 
Range on Protein: 172-402
Range on HMM: 55-295/296.0
DDNRIILTANPDLDMCQreFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKsKCRQYWPNAIteQEKFGPFIVLLKNTQ
| ||..|.     .  .  .||| |||.. . |.|. |..|.|.|. .|| |...|   ..|.|||  .  | .. .||||    .|..|...| . ...
DynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveek

AYSDFVTRQLCITIQ---------DGSNDSHTLTQYHLTTWPD-QGVPDYATSLMTLYKRVM---NTW--SPSQGPILVHCSAGIGRTGIFIAIDLALEQ
 |.....|.. .| .         . . .  ......||.|.  . ||  ...|. | .||    .     | .||..|..| | .|.|...||| .||.
qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlel

AKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGKT
..||. .|. . . .||..| ..|.. ..| .. | . | ..|.|.
vekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 172-418 3.3e-48 159.0 In-house 58-257 (392) alignment 
Range on Protein: 172-418
Range on HMM: 58-257/392.0
DDNRIILTANPdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGkskcrqywpnaiteqekfgpfivllkntq
| .|..|      |. .....|| |....   | |...|||   .| ||| ...||.. .|.|.||||||                              
dsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.............................

aysdfvtrqlcitiqdGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINR
                  .| .| .|.|.| |||..|| ...||. . | |   .     |...|||||.||||. |.||  . .|||  ..|   ..  
................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtn

LRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKK
.|..|  |||. .|| |.. ||.|...  .| | .  .|  .|.|. 
irrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst
subfamily_PTPN14_pd Subfamily PTPN14 172-394 2.1e-46 153.3 In-house 62-293 (300) alignment 
Range on Protein: 172-394
Range on HMM: 62-293/300.0
DDNRIILTANPDLdmcQREFINANYVDGY--SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNA--ITEQEKFGPFIVLL
.|||. |... .    . ..|||  .     .....|...|||...|. ||| ..|..    |||||. .|.|| |. .|.|.     .. .|| | |  
ednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt

KNTQAYSDFVTRQLCITIQDgSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYK-------RVMNTWS--PSQGPILVHCSAGIGRTGIFIAIDLALEQAK
| ..  . ..|..| .     |..  |.     | |||.|||.  .. .   .       .. .. .   |. |.|||||||.||||. |  || ..  .
kfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatle

KEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVF
.. .||   ...|||.||| .||.| || |..... 
hneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPRN_pd Subfamily PTPRN 172-397 2.5e-46 152.7 In-house 69-292 (297) alignment 
Range on Protein: 172-397
Range on HMM: 69-292/297.0
DDNRIILTANPDldMCQREFINANY-VDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAitEQEKFGPFIVLLKNT
|..|. |... .    . ..|||   .|   |.  |..||||. .|. ||| ..|..  | ||.||.|.| | ..|..|||.    .| .. . | |   
dhsrvklkeeas..aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvse

QAY-SDFVTRQLCITIQDgSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKE-GVIDFAGI
  .  |.. | . .   . .... |.||.|  .||..|||  | ||. . ..|  ..     ||.||||.| ||||..|.||| |.. .|    || |  
hiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaat

INRLRQQRMKMVQSLDQYVFLHDAVFEEI
.. ||.|| ..|.. ||. |   || ||.
lehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 172-395 8e-38 125.0 In-house 46-257 (267) alignment 
Range on Protein: 172-395
Range on HMM: 46-257/267.0
DDNRIILTANpdldmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLkegGKSKCRQYWPNAITEQEKFGPFIVLLKNTQ
||.|.||  .      ..|.||| ||.|| . .... ||.|.|||  ||. .| ...   ||.|||    .. . |..||  . . .|.  . |     .
ddtrvilrtk......eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslek

AYSDFVTRQLCITIQDGSndSHTLTQYHLTTWPDQ-GVPDYATSLMTLYKRvmNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
   |.    | . ... |  .| .| |.   |  .     |   |. .  .  |     . |..|.||.|.||.| |. ||  ||.||.||| |    . 
eendyqiitlelkfknes..ahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflr

RLRQQRMKMVQSLDQYVFLHDAVFE
..|.||. .|.....|...|. . |
kirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 172-395 1.3e-37 124.4 In-house 54-275 (307) alignment 
Range on Protein: 172-395
Range on HMM: 54-275/307.0
DDNRIILTAnpdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFG--PFIVLLKN
| .||...     |    ..| |||.    . ||.. .|||..||  .|| .. ||.  |..|| |. | .| ||.||||    ..  ||  |  . ..|
dkgrivvkf....dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan

TQAySDFVTRQLCITIQ----DGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVmntwSPSQGPILVHCSAGIGRTGIFIAIDLALEQA-KKEGVID
  |   .   . .| .     | ...| |....  . |||.|||.   . . | . |       . |..||||||.||.|  .|| |  ..  . .   |
lga.kklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd

FAGIINRLRQQRMKMVQSLDQYVFLHDAVFE
   ... ||.||   .|.  ||..||  ..|
mkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 172-311 3.3e-25 83.6 In-house 46-182 (297) alignment 
Range on Protein: 172-311
Range on HMM: 46-182/297.0
DDNRIILTANPdldmCQREFINANYVDGY--SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKN
||.|. |   .     .|..|||.||         ||. .|||...|. ||| |....    |||..||.|.|..||  |||..  |. | | ..|    
ddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvefls

tQAYSDFVTRQLC---ITIQdgsNDSHTLTQYHLTTWPDQGVPDY
 .   .| . .|    .  .   ..|  ..     .||| |||  
.stsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 173-455 2e-69 229.1 In-house 57-334 (515) alignment 
Range on Protein: 173-455
Range on HMM: 57-334/515.0
DNRIILTANPdlDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQA
 .|..|      |  . ...|| |. ..   | |...||| | .. ||| |..||..  |.|.|||||| |.|| .|||.  ..  ||| . | |  ..|
svrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea

YSDFVTRQLCITIQDgsnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRL
 .. . |.| .. .|   ||.|.||.|.| |||.|||  ..||. | | |    .  . |...|||||.||||..|.||  . .||.  ..|   ... .
ctggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtni

RQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQYHLLCELTPDPNDVECKSANAHSN
||.|...||  .|| |...|| |..   .| | .  .|  .| |.        . .  ... |  |.|||   ...|. .. |
rqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdn
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 173-394 8.8e-63 207.0 In-house 42-265 (274) alignment 
Range on Protein: 173-394
Range on HMM: 42-265/274.0
DNRIILTANPDlDMCQREFINANYVDGYSR-SKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITE--QEKFGPFIVLLKN
  |..|...   .  . ..|||||. ||.. || || ||||. ||. ||| .|.||.   |||||||||  ..|| .|.|.|.    .|..| . .  ..
nsrvllesess.ededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvek

TQAYSDFVTRQLCITIQDGsndSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPS---QGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFA
.    |.  |.| .  .     ..... |  | |||. .|| |..|. | . | .. . .    .|..|||||||||||.||||..|. | ..|.|.|  
iverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

GIINRLRQQRMKMVQSLDQYVFLHDAVF
.|.  ||..|  |||. .|| ..| |. 
kivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 174-394 2.7e-69 228.4 In-house 62-276 (288) alignment 
Range on Protein: 174-394
Range on HMM: 62-276/288.0
NRIILTANPDLDmcQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAiTEQEKFGPFIVLLKNTQAY
.|. |.  .. .  . ..|||.|.||. ..|||..||||. .|. ||| |.....   |||||.| ||||.|| .|||.|  .....| . | |....  
krvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskel

SDFVTRQLCITiqdGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLR
 |||.|.| .     ...  ..|||. ..|||.|||. .. |. | . | .. .  .|||.||||||.||||.|||.| .... ..| .|| ||....||
edfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklR

QQRMKMVQSLDQYVFLHDAVF
.||. .|| | ||.|..... 
kqRallvqtlkqYefiyevll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 174-406 7.5e-61 200.5 In-house 48-275 (283) alignment 
Range on Protein: 174-406
Range on HMM: 48-275/283.0
NRIILTANPDldmcqrEFINANYVD---GYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITeqEKFGPFIVLLKNT
.|. | ...       ..||| ..     | ..|||. .|.|...| |||| ....|. ..|||||||.|. . || ||||.  .  |..|.| | |.. 
wrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs..edyGeftvtlrke

QAYSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
 .   |. ..| .  .  ....  |. | .  | . |      ||. . | . .     .|||.||||.|||||..|||.  ....|. | |.|   ...
ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvk

RLRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILI
 .|.||| .||.|||| ..|..|.|. .|| |.|  
imreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 174-395 9.1e-58 190.3 In-house 18-237 (237) alignment 
Range on Protein: 174-395
Range on HMM: 18-237/237.0
NRIILTANPDLdmcqREFINANYVDGYS-RSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAiTEQEKFGPFIVLLKNTQA
.|..|  .        ..|||.|..|.    |||...|||....  ||| ..|||.   ||||| | || . || .|||..  . . .| . | ||  ..
srvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkee

YSDFVTRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTW--SPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
.||.  | | .. .   ..   . ||..|.|||.|||.....|. . |...|     .  || ..|||||.||||||. ||  | |||.. |.|    . 
fsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvy

RLRQQRMKMVQSLDQYVFLHDAVFE
 . ..|  ..|. |||||.|....|
sieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 174-394 3.6e-36 119.4 In-house 69-286 (305) alignment 
Range on Protein: 174-394
Range on HMM: 69-286/305.0
NRIILTANPDldmcQREFINANYVDGY-SRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQA
. ... ..|       ..| ||||       |... .|||. .|. .||... |..   |||| |  | || || |||| |  |. ..   ||. . . .
qsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs

YSDFVTRQLCITIQDGSN---DSHTLTQYHLTTWPDQGVPDYATSLMTLykrvMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQ-AKKEGVIDFAGI
       .. ||. . .    .. .. . . | |||.|||    . . |    . .   |. ||.|||||||||||  .||.  ||. |..  .  .  .
kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslel....lsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpel

INRLRQQRMKMVQSLDQYVFLHDAVF
.. ||.||   .|.  ||.|.|  ..
vkalrdqrafsiqndvqylfihrvml
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 175-412 4.4e-55 181.9 In-house 64-294 (439) alignment 
Range on Protein: 175-412
Range on HMM: 64-294/439.0
RIILTANPDLdmCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKskcrqYWPNaiTEQEKFGPFIVLLKNTQAYS
|..|   | .   .  .|||||..||   | |..|||| |.|  ||| |..... | |||||.| |  |     |||    ..  .|  .|         
rvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps..daevcygdiavrvdrnielp

DFVTRQLCI-TIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTlYKRVMNTW--SPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINR
..| | . .   .| ..  .|. |.| ..|||. ||  |. ..  . | .|.   .   ||..||||||.||||  ||.|.|||| | |  .|  ||.. 
nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld.flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkv

LRQQRMKMVQSLDQYVFLHDAVFEEIICGKTDILIENYTVE
||.|| .|||.| ||||...||.|.|. |.. ..|...  |
lrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 175-398 1.1e-39 131.2 In-house 45-271 (285) alignment 
Range on Protein: 175-398
Range on HMM: 45-271/285.0
RIILTANPDLDMCQREFINANYVDGYSRS-KKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNT--Q
| |  .   |   .|..| |...    .    |.|||||. .|| |||..|.||.   ..||  | |||  ||  |.|. . |  ||| . . | .   .
rcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckee

AYSDFVTRQLCI-TIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNtWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIIN
| .  .   | .   .| |..   . . ..  ||||  |. |  .. ||| | .   | . || ||||||.|||  |. || |  .  ..  |..  |. 
aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivr

RLRQQRMKMVQSLDQYVFLHDAVFEEII
 .|  |.. |||  |..||.  ..| .|
emramrfqavqshmqflflyvvlmeyfi
subfamily_CG42327_pd Subfamily CG42327 177-325 5.7e-24 79.4 In-house 46-193 (319) alignment 
Range on Protein: 177-325
Range on HMM: 46-193/319.0
ILTANPDLDmcQREFINANYVDGYSRSK-KYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAIT--EQEKFGPFIVLLKNTQAY
.|   .| |  . |...|.|| ||  ..  |...| .....  ||| ..|. .   || ||.| | |  .| .|.|   |  ... .| . | ||. .. 
vlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevk

SDFVTRQLCITIQDGSnDSHTLTQYHLtTWPDQGVPDYATSLMTLYKRVMNT
  ...  | .   |..  |  || |    |.. .||   ..|...  .| ..
dryaistlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevrss
0044763 (Phosphotyrosine protein) phosphatases II 183-392 4.1e-32 106.6 In-house 12-166 (178) alignment 
Range on Protein: 183-392
Range on HMM: 12-166/178.0
DLDMCQREFINANYVDGYsrskKYVTTQGPmkntlVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITeqekfgpfivllkntqaysdfvtrqlc
  ...  ..|||......     |.....|     .|.. |....   .||.||. .|.|. || .|||                               
leglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...........................

itiqdgsndshtlTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQakkeGViDFAGIINRLRQQRMkMVQS
              ||. . .|| ||||    .. ... . .  ....||.|||||||.||.| ..|..| ...    |. ..  .|...|..|. .|..
.............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

LDQYVFLHDA
 .|. .|.. 
pgqlrqLyef
subfamily_PTPN3_pd Subfamily PTPN3 184-394 2.8e-60 198.6 In-house 60-272 (280) alignment 
Range on Protein: 184-394
Range on HMM: 60-272/280.0
LDMCQREFINANYVD----GYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaITEQEKFGPFIVLLKNTQAYSDFVTR
|.  . ..||||||.    . . ...|..||||...|  |||...|...   ||||| | | |. || ||||.  ... ..| | | ...... . .|.|
lkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlr

QLCITIQDgSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKM
.|... .. ........|   . |||.|||| ....... .|| .. | .. |..|||||||||||..|....||    ..  .    |. ..|.||. .
elvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqraml

VQSLDQYVFLHDAVF
||. .|| |. .|..
vqtasqykfvCeail
subfamily_PTPN1_pd Subfamily PTPN1 184-409 9.2e-47 154.1 In-house 51-283 (290) alignment 
Range on Protein: 184-409
Range on HMM: 51-283/290.0
LDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAIT-EQEKFG--PFIVLLKNTQAYSDFVTRQ
|.  . ..|||. |.     ..|. ||||. ||   || ..|...  ..||| |. | .. || ||||.    .. ..    . | | ... .| .. |.
leradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrl

LCITIQdGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNT--WSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGV---IDFAGIINRLRQQ
| .. .  ..........| ||||| |||.  .... .  .| ..   |. .|| ..||||||||.| |. .|  | . .|..    .|    .  ||..
lelenl.ktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrky

RMKMVQSLDQYVFLHDAVFEEIICGKTDILIENY
|. ..|  ||  | . |. | . . |.|  ... 
rlGliqtadqlrfsylaileGakvikgdssvqkr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 184-389 5.1e-36 118.9 In-house 70-273 (301) alignment 
Range on Protein: 184-389
Range on HMM: 70-273/301.0
LDMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCI
..  .|  | ||...   .......||||.|||  ||| .. |     ||||..  |  ..||..| |  |.|. . | | . .||..   .  . .  .
ivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtl

TIQDG--SNDSHTLTQYHLTTWPDQGVPDYATSLMTLykrvMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQ
 ..|     ...|.| |  ..|.|.|||   . |. |    |.    |. ||.|||||||||.  ||. .    . . .  |...  ...||..| . ||
evedstgkfatrtvthyqysewtdrgvPkshaelfdl....melvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

SLDQYVFL
   |  ..
tnsqlywm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 184-392 2.5e-23 77.0 In-house 70-280 (302) alignment 
Range on Protein: 184-392
Range on HMM: 70-280/302.0
LDMCQREFINANYVDGYSRSKKYVTTQGPMKNTL---VDFWYLIWQERPVSIVMLTKLKEGGKsKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVtRQ
|.... ...||  |.  . ... . .| | ...     .|| ...||. ||.|.| . .|  |    ...|.   . ...| . |  .  .  .. .  .
leaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tr

LCIT-IQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKM
..|  . .|  .|   . |.|| |... ||.  ..|..  . | .  .... ....    |.|| |.|..  .|.|. .|.     . |.. .|.|| ..
yviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpra

VQSLDQYVFLHDA
|.||.|||.|. |
vdslkQyvslyia
subfamily_PTPRB_pd Subfamily PTPRB 185-396 9.1e-73 239.8 In-house 75-284 (293) alignment 
Range on Protein: 185-396
Range on HMM: 75-284/293.0
DMCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQeKFGPFIVLLKNTQAYSDFVTRQLCIT
|  . ..|||||..||.  .....||||. .|. ||| ..|...   |||||.| |.|| || .|||.  ...  .|   | |.... ..|.|.|.| |.
desgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkie

IqdgSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTW--SPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQS
    ........||| |.||| |||. ...|... ..| ..   . |..||.||||||.||||.|||.|  |.. ..| ..| .||. .||..|. .||.
k...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt

LDQYVFLHDAVFEE
 .||.|.|..| . 
ekqYifihqcvldl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 185-399 1.5e-11 38.5 In-house 65-281 (303) alignment 
Range on Protein: 185-399
Range on HMM: 65-281/303.0
DMCQREFINANYVDgYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAIT--EQEKFGPFIVLLKNTQAYSDFVTRQLc
 ...  .| |.|..    ||| . || |.  |  ||| .| ...   ...|    |  |      .|.     . |.    .  .|. .    .| . | 
klsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvl.

iTIQDGSNDSHtLTQYHLTTWPDQGVPDYATS----LMTLYKRVMNTWSPSQGPILVHCSaGIGRTGIFIAIDLAL-EQAKKEGVIDFAGIINRLRQQRM
 .. .|.  |  |  .|  .|| . .|  ...     .   . |.  .|.|. .. .  | | ||.| |  .. |     ...  .|.   .. .|. |.
.svsngdyksf.lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfetahlslhseqasldlvkclenvrngrl

KMVQSLDQYVFLHDAVFEEIIC
. || | |. ...  . | .. 
havqnlsqfsvvytllaehvld
subfamily_PTPRK_pd Subfamily PTPRK 186-431 3.5e-73 241.2 In-house 68-311 (314) alignment 
Range on Protein: 186-431
Range on HMM: 68-311/314.0
MCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaitEQEKFGPFIVLLKNTQAYSDFVTRQLCITI
  . ..|||...|.| |..... ||||...|. ||| |...|.  ||||||.|.| |. || .|||.   . |..|.. | | .|.. ...|.| . .. 
dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrvek

-QDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLD
 . | .. ... |.. ..||| .|| .||.|..| .|| ..  ...|.|.|||||| ||||.|||||  |. ...|||.|   ..  ||.... ||.  .
largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvetee

QYVFLHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQ
||.|..|...|  .||.| | . ..     . .. ||  | . .. .
qykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkee
subfamily_egg_pd Subfamily egg 186-399 6.1e-26 85.8 In-house 65-275 (307) alignment 
Range on Protein: 186-399
Range on HMM: 65-275/307.0
MCQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGgkSKCRQYWPNAITEQEKF--GPFIVLLKNTQAYSDFVTRQLCI
.   .|| ||.|.|     ... .| |.|||  ||| ...||.   |||||  ||    .|  |||.| ..  ..  | . .   . .  .| . |   .
qylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

TIqDGSNdshtLTQYHLTTWpdQGVPDYATSLMTLYkRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFA--GIINRLRQQRMKMVQ
 .  |..      . .|  |  ||  .... . . . ||.        |..|..  |. ... ..||..|| .  .  .  .     .  ||..|   |.
kl.vGgd....deerflehw..qgdvnnssdvyspl.rvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsve

SLDQYVFLHDAVF---EEIIC
|  .|.|..  |     ..| 
svllylfvyrlvlfffrdvig
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 187-395 1.4e-56 186.3 In-house 33-238 (239) alignment 
Range on Protein: 187-395
Range on HMM: 33-238/239.0
CQREFINANYVDGYSRS-KKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITeqeKFGPFIVLLKNTQAYSDFVTRQLCITi
 . ..|||.|.  |  | | |..||| .. .  ||| ..|||| . ||||| | || | ||.||||.. .   |.  . | |..|. ..|.. | . .. 
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kycnlrvtlrktevfadyiirtfvms.

QDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQ
| |  . . . |||.| |||.|||.|||... | ... .   |   | ..|||||.|||| |. ||  | ||||.  .|    .. .|..| .|||. .|
qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseq

YVFLHDAVFE
|||.| ||.|
yvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 187-395 2e-56 185.8 In-house 34-239 (239) alignment 
Range on Protein: 187-395
Range on HMM: 34-239/239.0
CQREFINANYVDGYSRS-KKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITeqeKFGPFIVLLKNTQAYSDFVTRQLCITi
 . ..|||.|.  |  | | |..||| .. .  ||| ..|||| . ||||| | || | ||.||||.. .   |.  . | |..|. ..|.. | . .. 
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kycnlrvtlrktevfadyiirtfvms.

QDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQ
| |  . . . |||.| |||.|||.|||... | ... .   |   | ..|||||.|||| |. ||  | ||||.  .|    .. .|..| .|||. .|
qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseq

YVFLHDAVFE
|||.| ||.|
yvfihlavle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 187-395 1.6e-40 133.8 In-house 71-285 (305) alignment 
Range on Protein: 187-395
Range on HMM: 71-285/305.0
CQREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNA----ITEQEKFGPFIVLLKNTQAYS-----DFV
   |.| ||||   . .|... || |...|  ||||. .|..  .| || .|.| |  || .|..      .. .||    .| .. .....     . .
wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

TRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVmntwSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDF-AGIINRLRQQR
 ..  ..|.   ....  |.||   |||.|||   .... | ..      ||.||| |||||||||||  . ..  |.|     .|.    |....|.||
vtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

MKMVQSLDQYVFLHDAVFE
 . .|. .||.|.|. ...
nnsiqtdaqylfvhqviln
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 187-404 1.1e-28 95.2 In-house 44-257 (290) alignment 
Range on Protein: 187-404
Range on HMM: 44-257/290.0
CQREFINANYVDgYSRSKKYVTTQGPMKN-------TLVDFWYLIWQERPVSIVMLTKLKEGGKS----KCRQYWPNAITEQEKFGPFIVLLKNTQAYSD
 . ..| ||.|  ..   . . || | ..       |. .||... ||.  ..||| . .|  .      | .| |... |. ||. . |  |.  .  |
fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

FVTRQLCITIQDGsnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNtwspSQGPILVHCSAGIGRTGIFIAIDLALEQAK-KEGVIDFAGIINRLRQ
. ||.|... .|.    .|.| . |  | .  |..   .|..| . |..    |. |..|||  || |  .. ||.|.      ..| . .. ... ||.
vetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRMKMVQSLDQYVFLHDAVFeeiicgktdI
|| ....|  .. |   ...         .
qralaitsalelafvdagiv.........l
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 187-278 7e-11 36.0 In-house 88-176 (349) alignment 
Range on Protein: 187-278
Range on HMM: 88-176/349.0
CQREFINANYVD--GYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAiteqeKFGPFIVLLKNTQAYSDFVT
   ..|||||.    .|  |||..|| |.  |. ||. .|  ..   .. |.. || .  || .|| .      ..  . | |.|.  |.  | 
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel.....sysnitvklqnsslyianvq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 188-395 7.3e-57 187.4 In-house 47-262 (270) alignment 
Range on Protein: 188-395
Range on HMM: 47-262/270.0
QREFINANYVDGYSR-SKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITE--QEKFGPFIVLLKNTQAYSDFVTRQLCIT
. ..|||||| |..  .|||....||...|| .|| .||.|.  .|||.|.|.| |..|| .|||.   |  . ..|   ||  ...  . .....| ..
ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle

iQDGsnDSHTLTQYHLTTWPDQGVPDYAT------SLMTLYKRVMNTWSPS--QGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQR
 ..|  ... |. .. .||||.|||  .       .|... . | .. .    ..|.|||||||.||||..||.| |..  .... .| . ||..||..|
.ekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdR

MKMVQSLDQYVFLHDAVFE
|..||  .|| ||. || |
malvqhpeqyeflykavve
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 188-392 8.5e-34 111.5 In-house 78-285 (310) alignment 
Range on Protein: 188-392
Range on HMM: 78-285/310.0
QREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaITEQEKFGPFIVlLKNTQAYSDFVTRQLCITI--
  ..| ||||      . .. .|||.. |..||| .|.|||  ||..| |  | |. ||  |||  .   | .|   |  . ...  .|   .|..|.  
yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygcirv.tnlsesseefeicnlavtfvp

-------QDGSNDSHTLTQYHLTTWPDQGVPDYATslMTLYKRVMNTWspSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMK
       |    .   ..  .   |||.||||      |. .|..      .|| .||||||..|... .|..|.......   .|.  ..  |...|..
dnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksrai

MVQSLDQYVFLHDA
 .|.  ||....  
ciqtelqyliidrv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 188-393 8e-32 105.0 In-house 65-265 (281) alignment 
Range on Protein: 188-393
Range on HMM: 65-265/281.0
QREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQd
  ..| |||.      . |. |||| |.|  ||| .||||   .|||| .. |  . || .|.|       .|  . |  ...     .|| .| .. . 
stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye.

GsnDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTwspSqGPILVHCSAGIGRTGIFIAIDLALEQAKKE-GVIDFAGIINRLRQ-QRMKMVQSLDQ
|  ... .|..    |||  ||. .  .. . ...      |  | ..|||||.||.| ..|...||.  .    . |   |. .||   |   ||.|.|
g..etrlithwlwkewpdwqvpessevmlkilrkirar...s.tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq

YVFLHDAV
|...   .
ymliwkvl
subfamily_ptpA1_pd Subfamily ptpA1 188-350 3.8e-30 100.0 In-house 74-249 (418) alignment 
Range on Protein: 188-350
Range on HMM: 74-249/418.0
QREFINANYVDGySRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITE---------QEKFGPFIVLLKNT--QAYSDF
  ..|||||.|| .  |... ||||. ||. ||| ..|..|   ||||..  |  . || .|||. |           .| || . | | .   .   . 
gsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdperei

VTRQLCITIQDGSNDshtLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTW---SPS---QGPILVHCSAGIGRTGIFIAI
.||.. .|..  . |   .|||.   |||. .||..  .  | . . |      ||   . ||.||||||.|||| | . 
itrnirltfegetrd...itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_eak_pd Subfamily eak 188-322 1.1e-11 38.7 In-house 77-207 (332) alignment 
Range on Protein: 188-322
Range on HMM: 77-207/332.0
QREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIqd
.  .|||  ..     .||. |  . .. .  || .. ...  .||.| .  | .  |  .|.|.   |. ||| . |  |.    . . ||.| ..   
rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelsk..

GsNDSHTLTQYHLTTWPDQGVPDYAtSLMTLYKRV
| |..| .  |..  | .  .| |   ...|.| .
G.nethrvlhykvfGwtettlpkye.dflalrkvm
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 188-308 1.1e-08 29.4 In-house 12-126 (130) alignment 
Range on Protein: 188-308
Range on HMM: 12-126/130.0
QREFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWqERPVSIV-MLTKLKEggkskCRQYWPNAITeQEKFGPFIVLLKNTQAYSDFVTRQlCITIQ
. ..|||..|    |...|. || |. .| .||| ..  || | .. .|  ..|       .|||..    | .   |..    .  ....  .  . |.
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsvee.....edeywpdseP.lewyeediivtltdrdefknikas.nleie

DGSNDSH-TLTQYHLTTWPDQGV
.  |.|| .|| .... || .| 
sdlneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 188-245 6.8e-06 19.8 In-house 59-117 (332) alignment 
Range on Protein: 188-245
Range on HMM: 59-117/332.0
QREFINANYVDGYSRSKKYVTTQGPMKN-TLVDFWYLIWQERPVSIVMLTKLKEGGKSK
. .| ||..|||||.   |. .| |... |   || .. . .|  |...  . |  | |
kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 189-431 7.3e-68 223.8 In-house 77-313 (315) alignment 
Range on Protein: 189-431
Range on HMM: 77-313/315.0
REFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAiteQEKFGPFIVLLKNTQAYSDFVTRQLCITIQDg
 ...|||..|||.. ..|...|||  ... ||| |...|    |||||.| || |.|. .|||.    .  .|.. | .|. . ....  | | .. .| 
sdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd.

snDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVF
  . ... |.|.|.||| ||| |...|| |...|.     | |.|.||||||.|||| ||..|  |.||. | .||   .|...||.|.||||...|| |
..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqf

LHDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIEAQ
..||..| ..|| | |  . |  . . |    |    | .. |
iydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 189-417 2.8e-65 215.7 In-house 89-311 (319) alignment 
Range on Protein: 189-417
Range on HMM: 89-311/319.0
REFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTklkeggKSKCRQYWPNAITEQEkfGPFIVLLKNTQAYSDFVTRQLCITIQDG
 ..||| .|.|| | .||...|||..||| ||| .||. .  .||.||      | || ||||. | ..|  . | | ..  .  ...| |.. .. .  
sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike..erfkvkvdsveetaeyvvrdielsedgk

SNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQ--GPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQY
 .|   .||.|.  |||.|||||.. ||.| |.|    |  .   .|.||||||.||||..|..|  |.. |.|  .|   ... ||||| ..||.| ||
ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFLHDAVFEEIICGKTDILIENYTVEIQKLK
 |.. |. || . |..|. . .. . ...| 
kfiysalleehlfghsdvampdfpayleels
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 189-417 1.3e-64 213.4 In-house 53-275 (284) alignment 
Range on Protein: 189-417
Range on HMM: 53-275/284.0
REFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTklkeggKSKCRQYWPNAITEQEkfGPFIVLLKNTQAYSDFVTRQLCITIQDG
 ..||| .. || | .||..||||..||| ||| .||. .  .||.||      | || ||||. | ..|  . | | ..  .  ...| |.. .. .  
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike..erfkvkvdsveeseeyvvrdielsedgk

SNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQ--GPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQY
 .|  ...|.|.  |||.|||||.. ||.| |.|    |  .   .|.||||||.||||..|..|  |.. |.|  .|   ... ||||| ..||.| ||
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFLHDAVFEEIICGKTDILIENYTVEIQKLK
 |.. |. || . |..|. . .. . ...| 
kfiysalleehlfghsdvalpdfpayleels
0041856 (Phosphotyrosine protein) phosphatases II 189-403 8.9e-44 144.6 In-house 19-177 (182) alignment 
Range on Protein: 189-403
Range on HMM: 19-177/182.0
REFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTklkeggkskCRQYWPnaiteqekfgpfivllkntqaysdfvtrqlcitiqdg
  .||||...|. ...... ||||...|. ||. ......  .||.||         ...|||                                     
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.....................................

SNDSHTLTQYHLTTWPDQGVPDyATSLMTLYKRVMNtwspSQGPILVHCSAGIGRTGIFIAIDLALEQakkeGvIDFAGIINRLRQQRMKMVQSLDQYVF
..  .. .||. . ||| ||||   .|  . ..| .    ..||.|||||||.|||| ..|..| ...    | ...  ... .|..|..||....||.|
ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyff

LHDAVFEEIICGKTD
|..|..|.. ..||.
lqlallellllkktr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 189-308 6.2e-10 33.1 In-house 122-235 (244) alignment 
Range on Protein: 189-308
Range on HMM: 122-235/244.0
REFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWqERPVSI-VMLTKLKEggkskCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCitIQD
  .||| .|    |. .|. || |. .| .||| ..  || | . |.|  ..|       .|||..   .       | | . . . .  . .|   |. 
ntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvlgsvee.....edeywpdseplewyeeditvtltdrdefknikasnle..ies

GSNDSH-TLTQYHLTTWPDQGV
  |.|| .|| . .. || .| 
dmneshqaltmfqisnwpsdgt
subfamily_PTPN13_pd Subfamily PTPN13 190-395 1.2e-53 177.1 In-house 61-267 (273) alignment 
Range on Protein: 190-395
Range on HMM: 61-267/273.0
EFINANYVDGYSR--SKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGP-FIVLLKNTQAYSDFVTRQLCITiQ
 .|||...         .|. .|||. .|  ||| ..|. .   |.|.|. ||.|| ||..|||.   .. |    . | | ..| ...|| |.| .. .
gyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk.d

DGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSpSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQY
  |..|. ... ....||| |||  |..|... ..| .  . ..|||.|||||||||.|..|.|| .|.  ...  .|   |...||.||  .||. |||
sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqy

VFLHDAVFE
.| . |. |
ifvykaile
0043147 (Phosphotyrosine protein) phosphatases II 190-390 8.5e-40 131.6 In-house 6-154 (172) alignment 
Range on Protein: 190-390
Range on HMM: 6-154/172.0
EFINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLkeggkskcrqywpnaiteqekfgpfivllkntqaysdfvtrqlcitIQDGS
 .|||.|.|.|   .... ||||. ||| ||| .....    ||.||.|                                                |..
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydpe

NDSHTLTQYHLTTWPDQGVPdYATSLMTLYKRVMN-TWSPSQGPILVHCSAGIGRTGIFIAIDLALeqakkeG-ViDFAGIINRLRQQRMKMVQSLDQYV
. ...  ||. . |||.|||  .  |. ... . .     ..||.|||||||.|||| ..|..| |        . ..  ... .|..|...||. .|| 
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FLH
||.
fly
0051429 (Phosphotyrosine protein) phosphatases II 191-396 3.4e-51 169.8 In-house 6-224 (272) alignment 
Range on Protein: 191-396
Range on HMM: 6-224/272.0
FINANYVDGYSR---SKKYVTTQGPMKNTLVDFWYLiWQERPVSIVMLTKLKEGGKSKCRQYWP----------NAITEQEKFGPFIVLLKNTQAYSDFV
 |||..|.|| |    ...  ..||...|  |||.| ....  .||.|... | |. || .|||          .  ...  .| . | |  .. ..|..
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

TRQLCITIQDGSNDSHTLTQYHLTTWPDQGVPDYAtsLMTLYKRVMNtwspsQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVID--------FAGII
 | |..|.. . .........| | ||| |||. |  | .| . . .     .||.|||||||..|||...|..| |..  .| ..|         ....
lrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

NRLRQQRMKMVQSLDQYVFLHDAVFEE
..||.||...||. .||.||..|. | 
eelraqrpgavqteeqylflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 191-391 3.8e-43 142.5 In-house 4-164 (174) alignment 
Range on Protein: 191-391
Range on HMM: 4-164/174.0
FINANYVDGYSRSKKYVTTQGPMKntlvdFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNaiteqekfgpfivllkntqaysdfvtrqlcitiqDGSN
.|||...|.. ...... .|||..     ||.......  ..|||...|| |. || .|||                                   . . 
yinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lred

DSHTLTQYHLTTWPDQGVPDYATsLMTLYKRVMNTWSP-SQGPILVHCSAGIGRTGIFIAIDLALEQAKkEGVIDFAGIINRLRQQRMKMVQSLDQYVFL
 ...  ||. . ||| |||| .. | ...|.| .  |  ..||.|||||||.||||...|..| | . . |...|   .. .||.||..|||. .|| ||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy
0046846 (Phosphotyrosine protein) phosphatases II 191-394 2.6e-40 133.4 In-house 14-170 (176) alignment 
Range on Protein: 191-394
Range on HMM: 14-170/176.0
FINANYVDGYsrskKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEkfgpfivllkntqaysdfvtrqlcitiqdgsn
.||||...|.    ....||||. .|| ||. ......   .|.||...| |. || .|||   ...                                 
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................................

dshtltQYHLTTWPDQGVPDYaTSLMTLYKRVMNTWSPSqGPILVHCSAGIGRTGIFIAIDLALEqakkEGVIDFAGIINRLRQQRM-KMVQSLDQYVFL
      ||. . ||| ||||. . |..|.. . .  .   ||.|||||||||||| ..|..|       |  ..   .. ..|.||. ..||. .|| ||
......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrfl

HDAVF
.... 
yefel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 191-409 5.5e-35 115.8 In-house 69-283 (288) alignment 
Range on Protein: 191-409
Range on HMM: 69-283/288.0
FINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQDGSN
.|.|| |      .. . .| |.. |.  .| .. ..    ||||..| | || |  .|.|  . |. ..| .    |. .|  | . .   . |.   .
yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskege

DSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVmntwSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLH
..  . . ||  |.|.|||.   | . | ...       | ||.||.|||.|||| .| | .|||... .  .    ....||..|.| .|.  ||...|
ekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvh

DAVFEEIICGKTDILIENY
  |.||..  |   | |..
rcvleelllkkykvlredf
0051082 (Phosphotyrosine protein) phosphatases II 191-393 1.8e-32 107.3 In-house 5-149 (151) alignment 
Range on Protein: 191-393
Range on HMM: 5-149/151.0
FINANYVDGYsrskkYVTTQGPMKntlvDFWYLIWQERPVSIVMLTKLKEGGksKCRQYWPNAIteqekfgpfivllkntqaysdfvtrqlcitiqdgsn
.||..||.|.     .  ..||.     ||. |....   .||.|....| |  .| .|.|..                                     
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

dsHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNtwsPSQGPILVHCSAGIGRTGIFIAIDLALEQakkegvIDFAGIINRLRQQRMKMVQSLDQYVFLH
  ......... |||.|.|..  ... . . ...   ...||.|||||||.||||...|..| |..      .... ... .|..|. .||. .|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAV
 |.
fal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 191-399 1.2e-24 81.5 In-house 69-278 (312) alignment 
Range on Protein: 191-399
Range on HMM: 69-278/312.0
FINANYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAIT-----EQEKFGPFIVLLKNTQAYSDFVTRQLCITI
.| ||.|   .. ...|.||||..|| . || |      .||..|. . | |  || .|  . ..     ..  .  .   ..      | .| ..   .
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvv

QDGSNDSHTLTQYHLTTWPDQGVPDYATSLMtlykRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDL---ALEQAKKEGVIDfagIINRLRQQRMKMVQS
   . .   | .|  ..|||.|.||   . .    |.. .    . |.. |||||.|||| .. |.    || . .|. | |   .   ||..| . |. 
vkatgqesklnhyqwaswpdhgmpdscdtal....rllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkd...sfvllrkdrarsvrv

LDQYVFLHDAVFEEIIC
. |||.   .|.| . .
fpqyvyalrcvleflys
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 195-273 1.7e-11 38.1 In-house 227-301 (440) alignment 
Range on Protein: 195-273
Range on HMM: 227-301/440.0
NYVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEggkSKCRQYWPNAiTEQEKFGPFIVLLKNTQAY
. ..|||. . ...|| |.  |..||| |. . |  .|.|| .|..     |  |||   |    |||| |  | ..  
qefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn.trsvtfgpftvghkgsenm
0049260 (Phosphotyrosine protein) phosphatases II 196-391 8.5e-40 131.3 In-house 1-144 (152) alignment 
Range on Protein: 196-391
Range on HMM: 1-144/152.0
YVDGYSRSKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWpnaiteqekfgpfivllkntqaysdfvtrqlcitiqdgsndshtl
..||| ...... ||||. ||| ||| ....     |||||.| | || || ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALeqakkeGVIDFAGIINRLRQQRMKMVQSLDQYVFLHD
 ||. . ||| |||| .  |. |.. .   .  ..||.|||||||.|||| ..|..| |        ...  .....|..|...|.. .|. ||..
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 197-393 1.1e-22 74.8 In-house 83-284 (302) alignment 
Range on Protein: 197-393
Range on HMM: 83-284/302.0
VDGYSRSKKYVT-TQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQA-YSDFVTRQL----CITIQD---
.||  . .|       | |.||  .| || | .   .| |....|... || .|. . . .. ||| . |  .. .   ..|  ..      . |..   
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

GSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKrVMNTWspsQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYV
 ..  .|.   . ..||| | |. | . . . |   ...   .  .|||||||.|||| ..||   ..  .|. | |.. |.  .|| |   ||. .| .
kkkvkktvdilafsawpdhGapkeaytaldilk.fcesy...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FLHDAV
.|   |
ylllcv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 203-390 2.1e-26 87.3 In-house 4-197 (199) alignment 
Range on Protein: 203-390
Range on HMM: 4-197/199.0
SKKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQDGSNDS-HTLTQYHLT
 ..|..|| |...|. ||| ..|.     |||.   .   ..    ||| . .   |.| . |  |   . .|..   | .| .  .  |   ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDQGVPDYATS--LMTLYKRVMNTWSP-SQGPILVHCSAGIGRTGIFIAIDLALE--QAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLH
.| ..  |. |    ..   . | . .    . |..|||| | | ||.|.|.|. .   .  |  |.|.  . .|||| |  .. ||..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 204-390 2.4e-26 87.1 In-house 4-196 (198) alignment 
Range on Protein: 204-390
Range on HMM: 4-196/198.0
KKYVTTQGPMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQDGSNDS-HTLTQYHLTT
..|..|| |...|| ||| ..|.     |||.   .   ..    ||| . .   |.| . |  |   . .|..   | .| .  .  |   ...| .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDQGVPDYATS--LMTLYKRVMNTWSP-SQGPILVHCSAGIGRTGIFIAIDLALE--QAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLH
| ..  |. |    ..   . | . .    . |..|||| | | ||.|.|.|. .   .  |  |.|.  . .|||| |  .. ||..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 205-382 4.4e-23 76.7 In-house 39-206 (255) alignment 
Range on Protein: 205-382
Range on HMM: 39-206/255.0
KyvttqgpmknTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNtqAYSDFVTRQLCITIQDG-SNDSHTLTQYHLTTW
           |.  |.  | | ..  .|||. ..| |. || .|.|    |. |.    |   .  . .| | | | || . |     ||.. |. . |
l..........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGW

PDQGVPDYATSLMTLYKRVMNtwspSqGPILVHCSAGIGRTGIFIAIDLALE------QAKKEGVIDFAGIINRLRQQRMKMVQS
...  |. |  .. ..| | .    |  ...||||.||||.  |. ..|.        .  . . .|.  ... ||..| . .. 
ieknaPelareilnilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht
subfamily_hpo-7_pd Subfamily hpo-7 208-382 7e-19 62.7 In-house 42-212 (263) alignment 
Range on Protein: 208-382
Range on HMM: 42-212/263.0
TtqgpMKNTLVDFWYLIWQERPVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVLLKNTQAysDFVTRQLCITI--QDgSNDSHTLTQYHLTTWPD
     . .|.  |.  | | ..  .|||.  .| |. || .|.|    |. |.    |   ..|   | . . | ..   ..     ||...|  . |..
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWie

QGVPDYATSLMTLYKRVMNTwspsqGPILVHCSAGIGRTGIFIAIDLALE------QAKKEGVIDFAGIINRLRQQRMKMVQS
.  |  | . . . | . |       .. ||||.||||.  |  ..|.        .  . . .|.  ... ||..| . .. 
kndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 210-397 4.8e-07 22.7 In-house 121-309 (346) alignment 
Range on Protein: 210-397
Range on HMM: 121-309/346.0
QGP-MKN--TLVDFWYLIWQERpVSIVMLTKLKEGGKSKCRQYWPNAITEQEKFGPFIVllKNTQAYSDFVTRQLCIT-IQDGSNDSHTLTQYHLTTWPD
| | |.|   . ||||.|.||. . .| |    .  |      . .     .  | ...  .| .|      ..  |  . .|  ||     .| . |  
qlpqmenesfvedfwymiyqeq.ihlvylmvpddklkntttslfndenggyqytgkmfi..nnrradvsgdpkeytievlpegnsdsvicqvhhhapwkh

QGVPDYATSLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEI
   |  .  .. . .. .      .  . |    | ||.  ||    |..|       .   |.  ..|||   |.|. ||  ..  ||. |
lqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 245-386 3.6e-07 24.0 In-house 149-291 (332) alignment 
Range on Protein: 245-386
Range on HMM: 149-291/332.0
KCRQYWPNAITEQeKFgPFiVLLKNTQAYSDFVTRQLCITIQDGSNDSHTLtQYHLTTWPDQG-VPDYA----TSLMTLYKRVMNTWSPSQGPILVHCSA
 ||..||.  ...  | |  . .. .. .|.   . . .|. .  .| .|.   |.  | |   .|.|     .|.   | |  .      |||.. |..
icrkfwpekrskk.df.pa.lsiqasddhsethmktfnltvtekkqdhqtv.lmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQY
|. .  |. .||. . .  .|  . |   .. .. ||.  ....  |
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpy
0048076 (Phosphotyrosine protein) phosphatases II 248-393 1.6e-27 91.4 In-house 1-139 (145) alignment 
Range on Protein: 248-393
Range on HMM: 1-139/145.0
QYWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCItIQDGSNDSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPSqGPILVHCSAGIGRTGIF
.|||. |...  .|.. . |.  .  .  .|. |..   . .. ... .||. . ||| |||| .  |..... . .  .   ||.|||||||.|||| .
pywpseilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtl

IAIDLALEqakkEGvIDFAGIINRLRQQRMKMVQSLDQYVFLHDAV
.|..| |.    .| ...  .....|.||...|.. .|. ||....
vaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 249-391 1.6e-25 84.9 In-house 2-139 (144) alignment 
Range on Protein: 249-391
Range on HMM: 2-139/144.0
YWPNAITEQEKFGPFIVLLKNTQAYSDFVTRQLCITIQdGSNDSHTLT--QYHLTTWPDQGVPDYATSLMTLYKRVMNTWSpSQGPILVHCSAGIGRTGI
..|. |...  .|.. ..|.  .  .  .|  ...| .   ... . .  ||. . ||| ||||... | .... . .  . . ||.|||||||.|||| 
snpseilpglylgslptaldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgt

FIAIDLALeqakKEGvIDFAGIINRLRQQRMKMVQSLDQYVFLHD
..|..| .    |.| ...  .....|..|. .|.. .|. ||..
lvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 291-429 8e-32 105.1 In-house 87-226 (440) alignment 
Range on Protein: 291-429
Range on HMM: 87-226/440.0
DSHTLTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWS-PSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFL
.|.|| |||   |||.||| .|  .. . . | ..    ..||.||||||| ||||. ||.|  | .||.   ||   .|| .|..| .|||. .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAVFEEIICGKTDILIENYTVEIQKLKKNDPSINCTGIE
|.||.| ..|| | || .. |  .....  .|  . . ..
heavlegllcgdtliledditerveqiqwpnphtdksplq
PTEN_1 294-350 2.1e-07 25.9 In-house 93-150 (196) alignment 
Range on Protein: 294-350
Range on HMM: 93-150/196.0
TLTQYHLTTWPDQGVPDYATSLMTLYkRVMNTWS--PSQGPILVHCSAGIGRTGIFIAI
   .|.   ..| |.|. .  .  .. .... ..  |... .|||| ||.||.|  .| 
sgveylhfpieDhgapslselfdick.sfiewllsdpngnvVlVHCkaGlgRsGtvvaa
PTPc_DSPc_SM00012 295-394 1.2e-33 110.8 In-house 2-104 (105) alignment 
Range on Protein: 295-394
Range on HMM: 2-104/105.0
LTQYHLTTWPDQGVPDYATSLMTLYKRVMNTWSPS--QGPILVHCSAGIGRTGIFIAIDLALEQAKKE-GVIDFAGIINRLRQQRMKMVQSLDQYVFLHD
...|| |.|||.|||....|...| . |..  . |  ..|..||||||.||||.|.|.|..|.| .|| . .|.  |...||.||..|||...||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVF
|. 
all
0038934 (Phosphotyrosine protein) phosphatases II 297-386 4.2e-08 28.6 In-house 81-166 (194) alignment 
Range on Protein: 297-386
Range on HMM: 81-166/194.0
QYHLTTWPDQGVPDYATsLMTLYKRVMNTW--SPSQGPILVHCSAGIGRTGIFIAIDLALEqakkEGViDFAGIINRLRQQRMKMVQSLDQY
.|.   .||.|..     ... . ......    ..| ..||| ||.||||...|  |        |  .    |...|. | ..... |..
eylklpfpddgtvPsle.illrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr....lgm.saeeAialfrekRpgaipnqdyl
subfamily_PTPDC1_pd Subfamily PTPDC1 298-391 2.3e-09 32.0 In-house 85-170 (182) alignment 
Range on Protein: 298-391
Range on HMM: 85-170/182.0
YHLTTWPDQGVPDYATsLMTLYKrVMNtWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAkkegvIDFAGIINRLRQQRMKMVQSLDQYVFLHD
..  .|.| ||.   . .... | |..  . ..| . ||| || ||||. ||  |   .      .. .  |. .|..| | .|. .|  ....
vynfgwkDygvasler.iLdivk.vva.falqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_CDKN3_pd Subfamily CDKN3 299-391 6.8e-07 23.0 In-house 103-190 (202) alignment 
Range on Protein: 299-391
Range on HMM: 103-190/202.0
HLTTWPDQGVPDYATSlMTLYKRVMNTWSPSQGpILVHCSAGIGRTGIFIAIDLALeqakKEGVIDFAGIINRLRQQR-MKMVQSLDQYVFLHD
|    .| .||| |.  . . . .  .    ..  ||||  |.||. . ||  | .     . .|..   |..||. .  . .|.. || .|..
hhypiadglvpdiasc.lkileelrinlkayrk.tlvhcygglgrsslviacllly....lddtiepkdaidklrdlkgsraiqtvkqynylse
Y_phosphatase3 Tyrosine phosphatase family 314-362 9.7e-07 23.9 Pfam-A 108-156 (164) alignment 
Range on Protein: 314-362
Range on HMM: 108-156/164.0
SLMTLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGV
.  . |..|...   ..||.|.||.||  |||...|. |.|  ...| .
dekkayrkvlealaeeegpvlfHCtaGKDRTGvvaalllsllgvdeeti
subfamily_CDC14_pd Subfamily CDC14 317-352 8.9e-06 19.7 In-house 250-285 (328) alignment 
Range on Protein: 317-352
Range on HMM: 250-285/328.0
TLYKRVMNTWSPSQGPILVHCSAGIGRTGIFIAIDL
.. |. ..    ..| | ||| ||.|||| .||  |
aivkkfleiaekaeGaiavhCkaGLGrtGtLiacyl
subfamily_eak_pd Subfamily eak 318-397 7.9e-06 19.5 In-house 226-305 (332) alignment 
Range on Protein: 318-397
Range on HMM: 226-305/332.0
LYKRVMNTwSPSQGPIlVHCSAGIGRTGIFIAIDLAL--EQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEI
..|. . |  ||  || . .. |  |.|.|. ||| .   ..||. .     .| . ...|.. |    |. |....|.. .
tlkkyiht.ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 322-397 5.7e-17 56.5 In-house 220-295 (297) alignment 
Range on Protein: 322-397
Range on HMM: 220-295/297.0
VMNTWSPSQGPILVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEI
 ...  | . ..|||||||.||.|. .  |  |.. .|. . | | |.. ||.|| ..||.|.|. .|.|||.. .
slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 329-393 1.1e-14 48.9 In-house 246-311 (319) alignment 
Range on Protein: 329-393
Range on HMM: 246-311/319.0
SQGPILVHCSAGIGRTGIFIAIDLALEQAKKE-GVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAV
||||. |||| |.||||. || |.|... ..    .|   ..  .|..| . |.. .|| |..  .
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 330-393 2.3e-12 40.9 In-house 265-340 (349) alignment 
Range on Protein: 330-393
Range on HMM: 265-340/349.0
QGPILVHCSAGIGRTGIFIAIDLALE---QAKKE-GVIDF--------AGIINRLRQQRMKMVQSLDQYVFLHDAV
  ..||||||| ||||... .|| |.     ..|   |..          |.| ||.||. ||| | |......|.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 334-401 6e-14 46.2 In-house 2-69 (69) alignment 
Range on Protein: 334-401
Range on HMM: 2-69/69.0
LVHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGK
.||||.| |||| |||| . . . | | ..|    .. .|. |  ||    .|.|.|||. | .  ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 335-401 8.5e-14 45.7 In-house 2-68 (69) alignment 
Range on Protein: 335-401
Range on HMM: 2-68/69.0
VHCSAGIGRTGIFIAIDLALEQAKKEGVIDFAGIINRLRQQRMKMVQSLDQYVFLHDAVFEEIICGK
||||.| |||| |||| . . . | | ..|    .. .|. |  ||   ..|.|.|||. | .  ||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 400-674 1.3e-66 219.9 In-house 1-292 (298) alignment 
Range on Protein: 400-674
Range on HMM: 1-292/298.0
GKTDILIENYTVEIQKLKKNDPSINCTGIEAQYHLLCELTPDPNDVECK--SANAHSNKNRSNNYLPPDKYIITLKD----TNDDYINASYLKGYQGKKE
|.|.|  |...  .|||.. ... . || ..... | . . . .. | .  ....  .|||  .... |.  . |..     . ||||||.|..|.|.. 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED----CCYQYWTG--SKTHGEFSIEVISKKIANGYTERNLKISFDK--ESRSVLQLQVTDWPQDGV
||..| |...|| .||.|... ...|||||   |.     . .||    ..|.||..... ||.    .. |.||.|  |  ..|.| ||..| ||. ||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

VRKAGTILQVINDVRNR-QKKG--PVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
 ..| ..|.....||   |. |  ||.|.||. | ||| .. ..  ||. |.|  |||||| |..|...||||.| |||  ||...  ....
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 401-667 3.4e-52 172.7 In-house 8-286 (319) alignment 
Range on Protein: 401-667
Range on HMM: 8-286/319.0
KTDILIENYTVEIQKL-KKNDPSINCTGIEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFI
..|. .... .. |.| .|.|   . | .|.... .|.|...  | .    .   .|||  | |. || .. |. ..     ||||||...||| |. .|
esdvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyi

IAQSPMENTVREFWKMIVDCKVSTIVMLCgdEDCCYQYWT--GSKTHGEFSIEVISKKIANGYTERNLKISF---DKESRSVLQLQVTDWPQDGVVRKAG
 || |..||. .||.|| . ..||||.|   .| | |||   . .....| ..| | . .. |. |....|     |. |.. |     ||. ||   . 
aaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyps

TILQVINDVRN----RQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDV
 ...... ||      ... ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
dlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
0051299 (Phosphotyrosine protein) phosphatases II 402-672 3e-72 238.8 In-house 3-286 (288) alignment 
Range on Protein: 402-672
Range on HMM: 3-286/288.0
TDILIENYTVEIQKLKKNDPsincTGIEAQYHLLCELTPDpNDVECKSANAHSNKNRSNNYLPPDKYIITLKD----TNDDYINASYLKGYQGKKEFIIA
|.| .|...  ..||..|..    ||...... |..|.|| ... . .  .. .|||. ..|| |.  . |..     ..|||||||..||. |..||..
teisveellklvlkllangl....tglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYW--TGSKTHGEFSIEVISKKIANGYTERNLKIS------FDKESRSVLQLQVTDWPQDGV
| |..||| .||.|. . .|..||||.. ..     |.|||   ||.|.|..... .| .. ..|| |.|...      .|.||| | ....|.|| .||
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

VRKAGTILQVINDVRNR--QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
   .  .|. ...||.   ...||||||||. |.|.|... . ..||| ..|| |||... |..|. .||.|.|.|||  .|...  |.
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 405-675 3.1e-48 159.4 In-house 5-300 (306) alignment 
Range on Protein: 405-675
Range on HMM: 5-300/306.0
LIENYTVEIQKLKKNDPSINCTGIEAQYHLLCELTPDP-NDVECKSANAHSNKNRSNNYLPPDKYIITLKDT---NDDYINASYLKGY--QGKKEFIIAQ
| ..   ....|.|.. |.. .|.| ... | .       . .  . .   .||| .| || |.  ..||.    ..|||||.|.|.   . .|..| .|
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatq

SPMENTVREFWKMIVDCKVSTIVMLCGDE----DCCYQYWTGS---KTHGEFSIEVISKKIANGYTERNLKIS---FDKESRSVLQLQVTDWPQDGVVRK
  .|.|| .||.|... .   |||.  .     . |..||  .   ...|. |.. .|.| .. |. |.|..|   ..||.|.| |.. ..||. || ..
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

AGTILQVINDVRNRQK------KGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGI---VDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
 |..|. ..||...|.      .||.|||||. . | | .  . | |.. . .|.   .|. .. |.||. . | | | .||. .| .|. ||.|.
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 412-670 5e-54 178.3 In-house 8-277 (288) alignment 
Range on Protein: 412-670
Range on HMM: 8-277/288.0
EIQKLKKNDpSINCTGIEAQYHLLCELTPDPNDVECKSANaHSNKNRSNNYLPPDKYIITLKD----TNDDYINASYLKGYQGKKEFIIAQSPMENTVRE
...| .| .   | ||.. .|. | .|  . ..   . |.   .||| .| || |   . ||.    .. |||||||..|...||..| .|.|. .|| .
pvakvakks.arnrtgfseeynsLaalektksvtagrlav.nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWKMIVDCKVSTIVMLC----GDEDCCYQYWTGSKT---HGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVR
||... . |.||||||     |..  | .||  ...   .|.. ......|  . ...|.| .  .|. . . |.| . ||..|| . .  .|.... | 
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvk

NR--QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINL
.   .. ||..||||. | |.|.. ..  .... ..|  .||. . . .|. ..  | ||.||  ||.|.  
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 412-541 2.4e-14 47.8 In-house 5-157 (350) alignment 
Range on Protein: 412-541
Range on HMM: 5-157/350.0
EIQKLKKNDPSINCT-GIEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLK------------DTNDDYINASYLKGY----QGKKEF
..|| .|  . |     ..... |  . . . |||.  .      ||| .| || ..  . ||               .|||||.|||      . . .|
kvqkrsklkliitknstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf

--IIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED----CCYQYWTGSKTHG
  | .|.|. .|| .|.|.|.  ||  |..|  | .     ||.||   . ..
kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 413-674 8.2e-80 262.8 In-house 7-280 (287) alignment 
Range on Protein: 413-674
Range on HMM: 7-280/287.0
IQKLKKNDPSINCTGIEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMI
. .. ....  . .| . |. .| ..| ....|  . |.   .|||... |.||.| . ||....|||||....||. ||.||||.||| ||.|.|||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

VDCKVSTIVMLCG----DEDCCYQYWTGSK--THGEFSIEVISKKIANGYTERNLKISFDK---ESRSVLQLQVTDWPQDGVVRKAGTILQVINDV-RNR
 | .|..|||||     ||. |||||. .|  . ||..||...... .||.||.|..  ..   . ..| | |.|.|.. | | .  ||| ||..  ...
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

QK--KGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
.|  ....|||||||| ||...|.. .....|| ||..||||| |  |  |||.| | |||. |.|..  |...
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN9_pd Subfamily PTPN9 413-671 6e-40 132.1 In-house 3-289 (297) alignment 
Range on Protein: 413-671
Range on HMM: 3-289/297.0
IQKLKKNDPSINCTGIEAQYHLLCELTPDpNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREF
|..| .   . .  |.  .|  . . ..    ...   .| ..||| .. |  |.  ..|. ..     |||||... ||. || || .| |...||..|
ieelvayvkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WKMIVDCKVSTIVMLCG----DEDCCYQYWT----GSKTHGEFSIEVISKKIANGYTERNLKIS--FDKESRSVLQLQVTDWPQDGVVRKAGTILQVIND
|.|. . .| .|||           | |||      |. .|..|..... .  . |..| |.|.   ..|||.|   |.. ||  || . | ..|.|.. 
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VRNRQK---------------KGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLY
||..|                . |.|||||  . |.| .... |.|.. . .| |||... |..|  .  .. | |||.  |  .  |
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0050432 (Phosphotyrosine protein) phosphatases II 414-674 1.3e-75 250.0 In-house 30-301 (308) alignment 
Range on Protein: 414-674
Range on HMM: 30-301/308.0
QKLKKNDPSINCTGIEAQYHLLCELTPdPNDVECKSANAHSNKNRSNNYLPPDKYIITLkDTNDDYINASYLKGY--QGKKEFIIAQSPMENTVREFWKM
. ||. .. .. ...|.... |....| ... .. .  .. .|||. ..|| |.  . | | ..||||||| .||    ...||..|.|..|||  ||.|
dllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrm

IVDCKVSTIVMLCGDEDC----CYQYW-----TGSKTHGEFSIEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVR
. . .|..||||.  ..     |.|||      ||...| |.....| .. ..|| |.|....  |.||| | ... |.|| .||  ..  .|. .. ||
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

NRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
.....||.|||||. |.|.|... . ..||| ..|| ||||.. |..|. .||.|.|.|||  .|...  |...
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 416-674 3e-98 323.2 In-house 5-295 (301) alignment 
Range on Protein: 416-674
Range on HMM: 5-295/301.0
LKKNDPSINCTGIEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDT----NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKM
|...  . . ...|.||. | | ......|.....|.. |......... .. |.. | .    . .||||||..||. ||.||.||.||..|...||..
lgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

IVDCKVSTIVMLCGDEDC----CYQYWTGS----KTHGEFSIEVISKK-----------------IANGYTERNLKISFDKESRSVLQLQVTDWPQDGVV
|.. |...|||... ...    |.|||  |    .. |.|........                   |||.||..|.. ||.|..|||||||||||||||
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvv

RKAGTILQVINDVRNRQKK---GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
|   |.||||.||  ||.|   ||||||||||||||||||||||.||||||||.||||||||.|||.||||||||||| ||||||. |.| 
reprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
0036941 (Phosphotyrosine protein) phosphatases II 416-674 2.5e-71 235.8 In-house 3-279 (297) alignment 
Range on Protein: 416-674
Range on HMM: 3-279/297.0
LKKNDPSINCTGIEAQYHLLCELTPdPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDC
||. ..... .... ... |..| . . . .. .  .. .|||. ..|| |.  . |.| ..|||||||..||. |..||..| |..||| .||.|. . 
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

KVSTIVMLCGDEDC----CYQYW----TGSKTHGEFSIEVISKKI--ANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ
.|..||||. ...     |.|||     .|.|.|.|.....| ..   ..|| |.|....  ..||| | ....|.|| .||   . ..|. |. ||...
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----KKGPVVVHCSDTVSRSGVYCSVSIALEQCK---AEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
    ..|||.||||. |.|||... . ..|.| .    || ||.... |..|. .||||.|||||  .|...  ....
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0039614 (Phosphotyrosine protein) phosphatases II 416-674 1.9e-69 229.7 In-house 22-291 (297) alignment 
Range on Protein: 416-674
Range on HMM: 22-291/297.0
LKKNDPSINCTGIEAQYHLLCELTPDpndVECKSANAHSNKNRSNNYLPPDKYIITLKD-----TNDDYINASYLKGYQG-KKEFIIAQSPMENTVREFW
|.. ..  ..|......  |..|.||    ..    .. .|||. ..|| |   . ||.      ..|||||||..||   ...||..| |...||  ||
llllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

KMIVDCKVSTIVMLCGDEDC---CYQYW--TGSkTHGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ-
.|. . .|..||||.  ...   |.|||  .|. |.|.|...... .  .||| |.|... ..||| | ..|.|.|| .||   . ..|.... ||... 
rmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
   |.|||.||||. |.|.|...   ..|||.. || |||... |..|. .||||.|..||  .||..  ....
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 417-672 5.7e-66 218.1 In-house 11-277 (278) alignment 
Range on Protein: 417-672
Range on HMM: 11-277/278.0
KKNDPSINCTGIEAQYHLLCELTPdpNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMI
 ..    ..|....... |.. ..  .. ..    .. .|||. ..|| |   . |....    .|||||||..||. ...||..| |...||  ||.|.
llelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmv

VDCKVSTIVMLCGDEDC----CYQYW-TGSKTHGEFSIEVISKKIANGYTERNLKIS--FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR--Q
 . .|.|||||.....     |.|||  ||.|.|.|...... .  ..|| |.|...   |.||| |.... ..|| .||     ..|. ...||..   
welgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealed

KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
..|||.||||. |.|.|... . ..||| . || ||.... |..|. .||||.|..||  .|...  |.
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 419-672 2.1e-71 235.9 In-house 5-272 (273) alignment 
Range on Protein: 419-672
Range on HMM: 5-272/273.0
NDPSINCTGIEAQYHLLCELTPdPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVS
 ... . |.......||..|.| . . .. .  .. .|||. ..|| |.  . |.| ..|||||||..||. |..||..| |..||| .||.|. . .|.
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TIVMLCGDEDC----CYQYWTG-----SKTHGEFSIEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK---
.||||. ...     |.|||       |.|.|.|.....| .. ..|| |.|....  ..||| | ....|.|| .||      .|. |..||. ..   
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

-KGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
 .||||||||. |.|.|... . ..|.| ..|| |||... | .|. .||.|.|.|||  .|...  |.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 420-676 1.2e-114 377.6 In-house 16-287 (305) alignment 
Range on Protein: 420-676
Range on HMM: 16-287/305.0
DPSINCTGIEAQYHLLCELtPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTND--DYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKV
. .....|.||||..|.|. ....||..|.||...|.......|..|..|.| |...|  |||||||..||..||..|.||.|..|||..||..||..||
arvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

STIVMLC----GDEDCCYQYWTGSKTH----GEFSIEVISKKIANGYTERNLKISF---DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKKG
||||||.    |..|.|.|||..|||.    ||||.|. |.| |..|.||.||||.   |||||.|||.|.||||..||...|...|..|..|...|||.
stivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd

---PVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTTY
   |..||||..|.|.||...|.||||..|.|..||||.|.|..|......|.||.||....|.....|....
kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 421-675 6.8e-26 85.4 In-house 21-288 (302) alignment 
Range on Protein: 421-675
Range on HMM: 21-288/302.0
PSINCTGIEAQYHLLCELTPDPNDveCKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTV---REFWKMIVDCKV
 |.. . ...... . ..  | .   ||.  ....||.|...  .|. .. |. ..|.|.||| ..  . ... |.|| |  ...    |||.|. . |.
ksldtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

STIVMLCGDEDCCY---QYWT-GSKTHGEFS-IEVISKKIANGYTER---NLKISFDKESRSVLQL--QVTDWPQDGVVRKAGTILQVINDV--RNRQKK
 ..|.| |.|.. .   ...   | .. |.  . |  .|. .   |.    . .  .  | |||     .| |.|. |  | ... . . .|  .. . .
vsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
 ..|.     . | |.  .. .|.|. ...  . . .. |..|  .| || .|.||.|.| ...|||.. 
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 422-674 2.9e-73 241.3 In-house 16-285 (290) alignment 
Range on Protein: 422-674
Range on HMM: 16-285/290.0
SINCTGIEAQYHLLCElTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLK------DTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDC
. . .| ..|.. |   .  .. |. . ..  ...||..|....| . |||.      | ...||||.|.|||. ||..|..|.|..||...|||.|.. 
akgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

KVSTIVMLCG----DEDCCYQYWTGS--KTHGEFSIEVISKKIANGYTERNLKISFDKE---SRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN---RQ
||. ||||.     ... |.|||. |  |. |||||.... .. |.|.||.|..  ...   ..|| |.|.| |...| | .  |||.||. . .   ..
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
 ....||||||||.||.|.|.. .....|| || .||||| |. |  ||| |.| .||. |....  |...
gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0045450 (Phosphotyrosine protein) phosphatases II 422-672 4.2e-66 219.1 In-house 23-304 (307) alignment 
Range on Protein: 422-672
Range on HMM: 23-304/307.0
SINCTGIEAQYHLLCELTPD-PNDVECKSANAHSNKNRSNNYLPPDKYIITLKD-----TNDDYINASYL--------KGYQGKKEFIIAQSPMENTVRE
  . ||...... |...|.. ... .. .  .. .|||. ..|| |   . |..      ..|||||||         .||  |..||..|.|...|| .
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWKMIVDCKVSTIVMLCGDEDC----CYQYW---TGSKTHGEFSIEVISKKIANGYTERNLKIS---FDKESRSVLQLQVTDWPQDGVVRKAGTILQVIN
||.|. . .|..||||......    |.|||    ...|.|.| ....|... .||| |.|...   ...||| | ... |.|| .||     ..|. |.
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

DVRNRQ----KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGI---VDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
 ||. .    |.|||.||||. |.|.|...   ..|.| ..||.   ||.... |..|. .||||...|||  .|...  ..
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 423-586 4.3e-14 46.7 In-house 69-236 (244) alignment 
Range on Protein: 423-586
Range on HMM: 69-236/244.0
INCTGIEAQYHLlceLTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKD--TNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTI
||.  |..   .   . |||. ..       | |||    || |   . |      . |||||..       |.|..| |. .|  .||||... .|  .
inanyiqgsqni...irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvl

VMLCGDEDcCYQYWTGSKTHgEFSIEVISKKIAN-----GYTERNLKISFD-KESRSVL-QLQVTDWPQDGVV
|.|   |.   .||  |.   |.  | |.  ...          ||.|  | .||   |  .|...|| ||  
vvlgsvee.edeywpdsepl.ewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
0040438 (Phosphotyrosine protein) phosphatases II 424-675 1.1e-68 227.2 In-house 16-279 (317) alignment 
Range on Protein: 424-675
Range on HMM: 16-279/317.0
NCTGIEAQYHLLCELTPDpnDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVST
..|... ... |..|..|  . .. .  .. .|||. ..|| |   . |....    .||||||| .|.. |..||..|.|..|||  ||.|. . .|..
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLCGDEDC----CYQYW--TGSKTHGEFSIEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR--QKKGPVV
||||.  |..    |.|||   ...|.|.|.....| .  .|.| |.|...   |.||| | ... |.|| .||     ..|. .. ||.   ...|||.
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvl

VHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
||||. |.|.|... . ..|||.. || |||... |..|. .||||.|.|||  .||... |....
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_PTPRN_pd Subfamily PTPRN 424-668 7.1e-34 111.8 In-house 27-288 (297) alignment 
Range on Protein: 424-668
Range on HMM: 27-288/297.0
NCTGIEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDT----NDDYINASYLKGYQGKK-EFIIAQSPMENTVREFWKMIVDCKVS
| . .|.... ||.   .|.  |  .|.   .||||.. || |. ...||..    ..|||||| .   . ..  .| .|.|. .|| .||.|. .  | 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMLCGDED----CCYQYW--TGSKTHGEFSIEVISKKI-ANGYTERN--LKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN--RQKKGP
 ||.|.  |.     |..||  .||.... . ....|..| .. |  |   ||    .|.|.| |.    ||. ||  .| ..|.    |    | .  |
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

VVVHCSDTVSRSGVYCSVSIALEQC-KAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.. .. ..
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 425-668 4.9e-55 181.4 In-house 5-262 (283) alignment 
Range on Protein: 425-668
Range on HMM: 5-262/283.0
CTGIEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLK---GYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIV
 .. ..... | .|.  . |....||. . .||| .. .| |.... ||  . |||||...     |. .|..||||||...||..||||. | |...||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLC----GDEDCCYQYW--TGSKTHGEFSIEVISKKIANGYTERNLKISFDKESRS---VLQLQVTDWPQDGVVRKAGTI--LQVINDVRNRQKKGPVVV
||     . .  | |||   ||. .||| . .      | .. ..| .  .  ..|   .   || || . |      ..  .  .   ....||||.||
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
||| .. |..|....| .... ..| .||||.| | .|  ...|| ||.||  .....
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN23_pd Subfamily PTPN23 425-671 9.4e-47 154.2 In-house 14-279 (288) alignment 
Range on Protein: 425-671
Range on HMM: 14-279/288.0
CTGIEAQYHLLC-ELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQ-GKKEFIIAQSPMENTVREFWKMIVDCKVSTIVM
 |........|  .   . ..  .  |. .|.||||.. || |.  ..|....|||||||..|.   |  .||..|.|...|. .||.|... |.|.|||
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVm

LCGDEDC----CYQYWTG----SKTHGEFSIEVISKKIANGYTERNLKISFDKE--SRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN------RQKKG
|   |.     . .||      ....|..|. . |.. .. . ||.||... ..   .||  ||.| ||. ||    .|.||... |..      |. | 
llskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt

PVVVHCSDTVSRSGVYCSVSIALEQC-KAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLY
|.|||||  | |.||.. |  |...  | .|..|. || ...|. .   | . ||..  |...  .
PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 425-674 1.9e-43 143.6 In-house 14-278 (281) alignment 
Range on Protein: 425-674
Range on HMM: 14-278/281.0
CTGIEAQYHLLCELTPDpNDVECKSANAHSNKNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTI
 .|   .|. | ..  | |  .   |..  .||| .|    |.  ...    ...| |||||....||.|.||.|..|.|. ... .||.|... |||.|
naGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLCGD----EDCCYQYWTGSK---THGEFSIEVISKKIANGYTERNLKI-SFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDV---RNRQKKGPVV
||.  .       |..||   .   . |.. .. ....  . | ||..|.   . |.|.| ||. | ||. ||  ..  .|.  ..|   .....| |.|
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSDTVSRSGVYCSVSIALEQCKAE-GIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
.|||  | |.|.| ..  ......||   .|| .| . .|...   | |. ||. .| ..  ... 
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPRG_pd Subfamily PTPRG 426-674 1.3e-52 173.8 In-house 19-289 (563) alignment 
Range on Protein: 426-674
Range on HMM: 19-289/563.0
TGIEAQYH-LLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTND-----DYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVST
.|...... |  | ...  |.|  ...   .|||  | .. |.  ..|... .     |||||.|..||| .|.||..| |...|.  ||.|| . .|..
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLCG----DEDCCYQYWT--GSKTHGEFSIEVISKKIANGYTERNLKISF------DK--ESRSVLQLQVTDWPQDGVVRKAGTILQVIND--VRNRQ
|||.          | .||   .|.| |....  |....   ||.|.|.|        ..  . . | | . |.||. ||  ..   |. ..     |..
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
. ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. |..|  ..  |.| |||  ..|..   |..
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0046845 (Phosphotyrosine protein) phosphatases II 427-675 1e-69 230.4 In-house 1-277 (284) alignment 
Range on Protein: 427-675
Range on HMM: 1-277/284.0
GIEAQYHLLCELTPDPN-DVECKSANAHSNKNRSNNYLPPDKYIITLKD-----TNDDYINASYLKGY-----QGKKEFIIAQSPMENTVREFWKMIVDC
|.|.... |. ||...  ....  . .. .|||. ..|| |.  . ||       ..|||||||..||       ||.||..| |..||| .||.|. . 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVSTIVMLCGDEDC----CYQYWT---GSKTHGEFSIEVISKKIANGYTERNLKISF---DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK-
.|..||||.. ..     |.|||    ...|.|.|.....|... ..|| |.|....   ..||| | ....|.|| .||   .  .|. ...||. .. 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

---KGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG---IVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
   .||.|||||. |.|.|... . ..||| ..||    |||... | .|. .||.|.|||||  .|...  |....
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPRB_pd Subfamily PTPRB 427-673 5.2e-50 165.1 In-house 26-286 (293) alignment 
Range on Protein: 427-673
Range on HMM: 26-286/293.0
GIEAQYHLLCELTPDpNDVECKSANAHSNKNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVM
..  .|. | ..  | . |.. .... ..||| .| || |.  . |    .....|||||.|..||. ..||| .| |. .|| .||.|. . |.|.|||
rfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LCG----DEDCCYQYWTGS---KTHGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ----KKGPVVVH
|          | .||       ..|. ........  . .. |.|||. .||.|.| |.. | ||. ||  |. |.|. .. ||...    .|.|.|||
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

CSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQ
||  | |.|.. ..   |.. . | .||.| .   .|...   | | .||  |....  ...
CsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN3_pd Subfamily PTPN3 427-668 1.7e-41 137.0 In-house 16-271 (280) alignment 
Range on Protein: 427-668
Range on HMM: 16-271/280.0
GIEAQYHLLCELTPDPNDVECKSAnAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLK----GYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVM
 . ||.. |    |. .  ... . .  .|||  . || |.  ..||... |||||.|..    . .  . .|..| |...|. .||.|. . |.|.|||
avlaqfeqlyrkkpglaisaarkp.enlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LCGD----EDCCYQYWT---GSKTHGEFSIEVISKKIANGYTERNLKISFDK--ESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ--KKGPVVVH
|          |.|||     . ..||||... ...  . |  |.| ..  .  |.|..|||| ..||. ||  ..  .|.... ||. .  |. |||||
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
||  . |.||.  . .||    |.  | . .. .|.|  .   | | .||. . . |
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_ptpA1_pd Subfamily ptpA1 427-630 1.3e-22 75.1 In-house 22-254 (418) alignment 
Range on Protein: 427-630
Range on HMM: 22-254/418.0
GIEAQYHLLCELTpDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTND----DYINASYLKGYQGkKEFIIAQSPMENTVREFWKMIVDCKVSTIVM
 |. ...|| |    |..      .  ..|||  | || ..  . ||  .|    ||||| |. |    |.|| .| |. ||. .||.|. . ..  |||
kikeefrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivm

LCGD-EDC---CYQYWT-------------GSKTHGEFSIEVIS--KKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ
|  . |.|   | .||              | .  | .|.|..   .        ||....|. |.| . | |   ||.  .  ..  . |..  . |||
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

K--------KGPVVVHCSDTVSRSGVYCSVSIALE
.        . |..||||  | |.| .|.  | ..
nqiipssdrnvpiivhcsagvgrtgtfctavimmk
DSPc_SM00195 428-672 5.1e-68 224.6 In-house 2-262 (263) alignment 
Range on Protein: 428-672
Range on HMM: 2-262/263.0
IEAQYHLLCELTPDPnDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVML
...... | | |..  .....  .. ..|||..|.|| |.  . ||...    .|||||.|.||.. ||..|..| |...||..||.|... ||..||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGDEDC----CYQYWTGS----KTHGEFSIEVISKKIAN-GYTERNLKISFDK--ESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK--KGPVVV
. .|..    |..||  .    .|.|..|........ .  .. |.|......  |.|.| |.|...||. ||  ..  .|.... |.....  .||.||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
|||. |.|.|......|.|.....|  ||.|.. | .|  .||.|.|||||  ||..|  ||
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 428-672 5.1e-68 224.6 In-house 2-262 (263) alignment 
Range on Protein: 428-672
Range on HMM: 2-262/263.0
IEAQYHLLCELTPDPnDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVML
...... | | |..  .....  .. ..|||..|.|| |.  . ||...    .|||||.|.||.. ||..|..| |...||..||.|... ||..||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGDEDC----CYQYWTGS----KTHGEFSIEVISKKIAN-GYTERNLKISFDK--ESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK--KGPVVV
. .|..    |..||  .    .|.|..|........ .  .. |.|......  |.|.| |.|...||. ||  ..  .|.... |.....  .||.||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
|||. |.|.|......|.|.....|  ||.|.. | .|  .||.|.|||||  ||..|  ||
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 428-673 2.3e-40 133.3 In-house 8-260 (267) alignment 
Range on Protein: 428-673
Range on HMM: 8-260/267.0
IEAQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC-GD
|| .. |. ..... . . .  |.   ..|| .. || |. .. |......||||||..||. |. ||. | |..||. .|...| | ||..||.|    
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf

EDCCYQYWTGS----KTHGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQ-VTDWPQDGVVRKA-GTILQVINDVRNRQKKGPVVVHCSDTVSRSG
.|   ..|       | . ....|   .|  | |    |.. | .||   . |     |  .   .     .. ..   .  .   |.||.||| | |||
tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsG

VYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQ
 .  .   ||. | ||..|.|.  . .|  ..| | |.|.|  |....  | .
tflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_CG7180_pd Subfamily CG7180 429-673 5.1e-51 168.1 In-house 16-291 (296) alignment 
Range on Protein: 429-673
Range on HMM: 16-291/296.0
EAQYHLLCELTPDPNDVECKSANA--HSNKNRSNNYLPPDKYIITLK----DTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVM
...|.|...|||  .  .|. .      .|||  . .|.|.  . |.    . ..|||||.|  ..  |||.|. . |...|| |||... | ..|..|.
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LCGDED---CCYQYWTGS--KTHGEFSIEVISKKIANGYTERNLKISFD------------KESRSVLQLQVTDWPQ-DGVVRKAGTILQVINDVRNR--
|.   |    . .||     . .||. .|....|     . |..|.                | | |...|.| |.  | |   . ....... ||    
LtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre

-----QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQ
     ...|||||..|| .||||||... ..||. . |. ||||.  ||.|| .|. | . |.|  ||||.. .. 
kvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 430-667 3.1e-49 163.0 In-house 2-250 (284) alignment 
Range on Protein: 430-667
Range on HMM: 2-250/284.0
AQYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCg
.... .|.|...  | .    .   .|||  . |. || .. |. .      ||||||...||| |. .| .| |..||. .||.|| . ..||||.|  
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

dEDCCYQYWT--GSKTHGEFSIEVISKKIANGYTERNLKISF---DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN----RQKKGPVVVHCSDTV
 .| | |||   . .....| ..| | . .. |. |....|     |. |.. |     ||. ||   .  ...... ||      ... ..|||||  |
.kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

SRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDV
 |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
0045098 (Phosphotyrosine protein) phosphatases II 431-673 1.6e-56 187.1 In-house 11-273 (278) alignment 
Range on Protein: 431-673
Range on HMM: 11-273/278.0
QYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITlkdtndDYINASYLKGYqgKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC-
...    |...|.....     . .|||  ..|| |   .       |||||||..||  .|.||..| |...||  ||.|. . ....||||.. ..  
lefefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

---CYQYWTGS--KTHGEFSIEVISKKIANGYTERNLKIS------FDKESRSVLQLQVTDWPQDGVVRKA--GTILQVINDVRNRQ-------------
   |.|||  .  .|.|.|.....| .. . || | |..        | ||| | .|. . ||  ||        .|.... .|...             
rekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

--KKGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGIVDVFQVTKTVRRTKPG-AVTTLEQYNSIYDVINLYIQ
  ..|||.||||  |.|.|... . . ||..  || ||.... |..|. .|| ||..||||. .|... ....
ldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 431-677 2.1e-29 97.5 In-house 21-282 (307) alignment 
Range on Protein: 431-677
Range on HMM: 21-282/307.0
QYHLLCELTPDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDE---
... |.. ||.   ||. |||.. |. .  .     . .....    ||| | ||      | || || |.|||. .|| |... || ...|||      
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviela

-DCCYQYWTGSK----THGE----FSIEV-ISKKIANG---YTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQkkGPVVVHCSD
   | |||   .    ..||     |..   .||.|         .||. . ..||.. .|| ..||. || .   | . ... ||  .   ||||||| 
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt..npvvvhcsa

TVSRSGVYCSVSIALEQC-KAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTTYK
 | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  |    ||
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 432-670 4.5e-43 142.6 In-house 29-286 (325) alignment 
Range on Protein: 432-670
Range on HMM: 29-286/325.0
YHLLCELTPDPNDVECKSANahSNKNRSNNYLPPDKY---IITLKD-TNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVML---C
. ||    .    |  | .|   .||| .| .. ||    . |.|| .. ||||||||. ...|. |. ||.|. .|. ..|....| . | .|.|    
fgllpsddgiakkvamkpen..kaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneld

GDEDCCYQYWTG----SKTHGEFSIEVISKKIANGYTERNLKISFDKE--SRSVLQLQVTDWPQDGVVRKAGTI---LQVINDVRNR-----QKKGPVVV
...| | .||      ||| | . ..... .    |  | |..   |.  .||| |.|.  |.. || ..  |.   ||... | .|     .  .|..|
lgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINL
|||. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | .||  ||. .  
hcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_PTPN13_pd Subfamily PTPN13 432-668 5.2e-39 129.2 In-house 17-265 (273) alignment 
Range on Protein: 432-668
Range on HMM: 17-265/273.0
YHLLCELTPDPNDVECKSaNAHSNKNRSNNYLPPDKYIITLKDTNDdYINASYLKGYQGKKEF--IIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED-
.. | || |  .  . |. ... .|||  | || |.  ..|.|    |||||..|   ||.|.  |..| |. .||..||.|. . |.. |.|.  . . 
fkelrelkpldtcevgkk.kenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekek

---CCYQYWTGSKT-----HGEFSIEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK-KGPVVVHCSDTVS
    | .||  ||      .. . .|..  .  .|.. |.|...    .||| | .|. ..||  || ..|  .||..  ||. |. .||.|||||  . 
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiG

RSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
|||.. .. ..|.  . .  .|| .. ...|. . | | | .||  .| .|
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 432-668 4.4e-36 119.3 In-house 26-275 (439) alignment 
Range on Protein: 432-668
Range on HMM: 26-275/439.0
YHLLCELTPDPNDVECKSANA-HSNKNRSNNYLPPDKYIITLKDT----NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD
.. .    || . . .  |.     ||| ..  . |   .||...       |||| |.|||  .| .| .| | ..|. .||..... |..|||||.  
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl

EDcCYQYWTGSK--THGEFSIEVISKKIANGYTERNLKISFD----KESRSVLQLQVTDWPQDGVVRKAGTILQV---INDVRNRQKKGPVVVHCSDTVS
 .  |.||  ..   .|. .. |  .     |. | .|.  .    .  |.|||.. . ||.  |  .|  .|.    ||   .... ||||||||  | 
ve.sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvG

RSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
|.|   .. ||||| |.|  ||.  . | .|. .   | .| ||  ||. .
rtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN1_pd Subfamily PTPN1 436-665 4.3e-36 119.1 In-house 13-264 (290) alignment 
Range on Protein: 436-665
Range on HMM: 13-264/290.0
CELTPDPNDVECKSANAHSNK--NRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC----GDEDC
 ... . .|.....|. ..|.  ||  .  | |.  |.|.... |||||| ..  . |...|..| |. |||  ||.|. . |  ..|||      ..  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CYQYWTGSKT-------HGEFSIEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR----QKKGPVVVHCSDTV
|.|||   .        . ......||... . || | |..     .|.|..|.   | ||  || .  .. |. . .||.     ...||.|.|||  .
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

SRSGVYCSVSIALEQCKAEGI---VDVFQVTKTVRRTKPGAVTTLEQYNSIY
 ||| .| |   | . ....    ||. .|   .|. . | . | .| .  |
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 439-668 1e-24 81.7 In-house 21-265 (281) alignment 
Range on Protein: 439-668
Range on HMM: 21-265/281.0
TPDPNDVECKSANAHS--NKNRSNNYLPPDKYIITLKD-----TNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DE
  ||    |   |     .|||  |    |   . ||         ||| | |..    |. .|..| | ..|  .||.|| . . ..|||||     . 
pgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr

DCCYQYWTGS----KTHGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQkkGPVVVHCSDTVSRSGVYC
. | .|.           ..|..     . .      |..|.. |.| . .    .||.  |   .  .|...  .| |    | |.|||  | |||   
ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars..tppvihcsagvgrsgtlm

SVSIALEQCKAE-GIVDVFQVTKTVRRTK-PGAVTTLEQYNSIYDVI
.| |||.  ..   . |. |.   .| |    .| ||.||  |. |.
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 440-673 1.6e-58 193.3 In-house 35-284 (319) alignment 
Range on Protein: 440-673
Range on HMM: 35-284/319.0
PDPNDVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED----CCY
.......  | .  ..||| .| |. |.  ..|.. .     ||||||.. ||| ...|| .|.|.|||. .||.|. . ..|..|||... .     . 
avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklk

QYWTGSK--THGEFSIEVISKKIANGYTERNLKIS---FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKK---GPVVVHCSDTVSRSGVYC
.||.  .  . |.. ... ...  ..|  |.||.     . |.|.| . | |.||...| .|| ..|......|. ..|   ||.|||||. | | | ..
kywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi

SVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQ
 ....||. | ||..|||.. ...|  ..  | . |||. ||...  ...
vldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 440-672 1.6e-53 176.6 In-house 29-277 (315) alignment 
Range on Protein: 440-672
Range on HMM: 29-277/315.0
PDPNDVECKSANAHS--NKNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC----GDEDC
|||.  . ..|  .   .||| .| || |.  . |    .. ..|||||||.|...  | .| .| | . .| .||.|... ||.||||.     ||   
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CYQYWTG----SKTHGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVR--NRQKKGPVVVHCSDTVSRSGVYC
| |||      |   |....|..| .   . . |.| .   .||| | | | |.||. || ......|..| .|.  |..|. ...||||  | |.|| .
crqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

SVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
|.   ..| | .  ||||.. |..|. .|  | | |.|  |||..  ..
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 440-668 7.2e-37 121.7 In-house 30-232 (392) alignment 
Range on Protein: 440-668
Range on HMM: 30-232/392.0
PDPNDVECKSAN--AHSNKNRSNNYLPPDKYIITL---KD-TNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDE--Dccy
|.|.  . ..|.     .||| .| || |.  . |    | ...||.||||..... .| .| .|.|   .. .||.|. . .|.||.|.   .  |   
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

qywtgskthgefsieviskkiangyternlkisFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR--QKKGPVVVHCSDTVSRSGVYCSVSIAL
                                   .. |.| | ..|.||...| ... ..|..|..|.    |   |...|||  | |.||  |.   .
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvv

EQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
 ..|   .||||..   .|| .|  | | |||  ||  .
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 441-668 1.2e-51 170.5 In-house 39-275 (315) alignment 
Range on Protein: 441-668
Range on HMM: 39-275/315.0
DPNDVECKSANAHsnKNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC----GDEDCCYQ
 | ||  |. | .  |||  | .. ||  . |    .| . ||.||....||. |. .| ||.|  ..|..||... . ....||||     |..  . .
hpldvakkienkq..knryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek

YWTGSK-THGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN--RQKKGPVVVHCSDTVSRSGVYCSVSIAL
||   | ..|....  .|... . || | | . |... | |.||..| ||. || . . .....|  |.    .. |..|||||. | |.| .....  |
ywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

EQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
.| .|| ..||... . ||. . ..| ..|||. |||..
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 443-667 3.8e-17 57.0 In-house 33-271 (312) alignment 
Range on Protein: 443-667
Range on HMM: 33-271/312.0
NDVECKSANAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD----EDCCYQYWTG--
.| || .     . ||  |    |.  .||   .. || | ..|     . |...|.|.|||.  ||.. .    ..|..|||      . | .| .   
sdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv

-------SKTHGEFSIEV-ISKKIANGYTERNLKISFDK---ESRsVLQLQVTDWPQDGVVRKAGTILQVINDVRNrqKKGPVVVHCSDTVSRSGVYC--
        . . |.  |. |  |  .  | | ||.       ||. . . | . ||. |.     | |...  |..   | ||. |||  | |.|  .  
gfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkk..dkkpviahcsagvgrtgtlali

-SVSIALEQCKAEGIVDVFQVtktVRRTKPGAVTTLEQYNSIYDV
 |.  || . . . . |.| .   .|. .  .| .. ||     .
esmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrc
0040439 (Phosphotyrosine protein) phosphatases II 444-672 1.9e-61 203.1 In-house 2-246 (249) alignment 
Range on Protein: 444-672
Range on HMM: 2-246/249.0
DVECKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYW-
.... .  .. .|||. ..||.|   . |....    .|||||||..||. |..||..| |...||  ||.|. . ....||||. .. .    |.||| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-TGSKTHGEFSIEVISKKIANGYTERNLKIS--FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ----KKGPVVVHCSDTVSRSGVYCSVSI
  ||...|.|.....| .. ..|| |.|...   |.||| ||..|.|||| .||     ..|. |. ||. .    |.|||.||||. |.|.|...   .
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
.||| . |. ||.... |..|. .||||...|||  .|...  ..
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 444-673 1.2e-54 180.5 In-house 37-287 (307) alignment 
Range on Protein: 444-673
Range on HMM: 37-287/307.0
DVECKSANAHSN--KNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQY
| ..| .. . |  |||...  . ||. . || .|     ||||||..|||. ||.||.|| |.|.|. .||.|| . .| .||||   ..     | .|
dkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WT--GSKTHGEFSIEVISKKIANGYTERNLKISFDK-------ESRSVLQLQVTDWPQDGVVRKAGTILQVINDVR--NRQKKGPVVVHCSDTVSRSGVY
|.    . .|.  ....|.. .. |..|.|..|  |       .|| |.| . | |.   | . | ..|..|. ||  ......|.|||||  |.|||..
WpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif

CSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQ
 .... |.|.|||  ||.|...| .|. ..  |. ||||  .|  .  |..
valdsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN14_pd Subfamily PTPN14 444-675 1.8e-35 117.4 In-house 40-299 (300) alignment 
Range on Protein: 444-675
Range on HMM: 40-299/300.0
DVECKSANAHSNKNRSNNYLPPDKYIITL---KDTNDDYINASYLKGYQGK--KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD----EDCCYQYW
.... . .   .||| .. || ..  . |   |.....||||| .|   |   ...|.||.|.|.||..||.|. . .|. ||||  .     . ...|.
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

TGS------KTHGEFSIEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQ---VINDVRNR--------QKKGPVVVHCSDT
  .       ..|.| .    .. .. .. . ||. .   || |.|. || ||||..|| .   . |.    .. ||..        ..| ||.||||. 
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

VSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
| |.||   . . ..  . .  .|. .| ...|. .   | || ||. .|.|.  |.. .
vGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 445-660 8.8e-20 65.6 In-house 42-269 (301) alignment 
Range on Protein: 445-660
Range on HMM: 42-269/301.0
VECKSANAHSNKNRSNNYlP--PDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD----EDCCYQYWTGSK
..   |  . .|.| ..  |  |.  .  ..| .   | | ...     . ||..|.|..||  .|| |.|  .| .||||.      |. | .| . . 
itesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

T----HGEFSIEVISKK--IANGYTERNLKIS---FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKkgPVVVHCSDTVSRSGVYCSVSIAL
.     | |.|.. .|.  . .  ..|.|..     . ..|.|.  | ..|.. || .    . .... |.. .|  |.|||||. . ||  . .  .  
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek..PivvhcsaGiGrsvafigteyla

EQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQ
 . .|.  ... .  | .|  .  .| | .|
reveadptieltealkhlrehrwngvqtnsq
subfamily_PTPRA_pd Subfamily PTPRA 446-671 5.8e-54 178.2 In-house 51-294 (330) alignment 
Range on Protein: 446-671
Range on HMM: 51-294/330.0
ECKSANAHSNKNRSNNYLPPDK--YIITLKDT--NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYW--T
|  | .   .|||  | || |    |.. |.   . ||||||...||. |..|| || | |.|| .||.|| . | .|||||      .|. |.|||   
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

GSKTHGEFSIEVISKKIANGYTERNLKIS------FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN--RQKKGPVVVHCSDTVSRSGVYCSVSI
|. |.|.  .||  ..... || |.. .        .|.|| | |.  | ||. ||  ..  .|.... |..  .|. ||.|||||  | |.| .. .. 
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda

ALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLY
 ||. |||..||||.. | .|  .|  | |.|||. || |.  |
vlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN12_pd Subfamily PTPN12 446-674 3.3e-52 172.2 In-house 33-279 (290) alignment 
Range on Protein: 446-674
Range on HMM: 33-279/290.0
ECKSANAHSNKNRSNNYLPPDKYIITL--KDTN--DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGS
|. ... . .|||  . || ||  ..|  .. .  .|||||...|| .||.|.| ||.|. .|. .||.|| ...|. .||.|     .   | .||. .
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

----KTHGEFSIEVISKKIAN-GYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK--KGPVVVHCSDTVSRSGVYCSVSIALE
     ..|||.......|  . ... | ||. ..||||.| |.. |.||  || ..| ..|..|..||..|.  . |.|||||  | | |. ... .. |
geeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvre

QCKAEGI---VDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
. ||| |   .|||..  ..|. .. .| | |||. .|  .  ..|.
llkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
0042113 (Phosphotyrosine protein) phosphatases II 447-672 1.2e-57 190.5 In-house 3-243 (245) alignment 
Range on Protein: 447-672
Range on HMM: 3-243/245.0
CKSANAHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYW--TG
. .  .. .|||. ..|| |   . |....    .||||||| .||. .. ||..| |...||  ||.|. . ...|||||. .|.     |.|||   .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SKTHGEFSIEVISKKIANGYTERNLKIS--FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRN---RQKKGPVVVHCSDTVSRSGVYCSVSIALEQ
|.|.|.|.....| .. ..|| |.|...   |.||| |.... ..|| .||     ..|.... ||.   . ..|||.||||. |.|.|... . ..|||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

CKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
 ..|. |..... | .|. .||||.|..||  .|...  ..
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 448-675 1.6e-46 153.6 In-house 23-271 (274) alignment 
Range on Protein: 448-675
Range on HMM: 23-271/274.0
KSANAHSNKNRSNNYLPPDKYIITL--KD---TNDDYINASYLKGYQGK-KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGS
..   ...||| .. || ..  ..|  ..    . .|||| |.|||... | .. .| |. ||| .||.||   .|. ||||      .|. | .|.  .
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

K------THGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ-----KKGPVVVHCSDTVSRSGVYCSVS
.      ..|...|.| ...  |.|. |.| ..  ...|||     ||||   . ..| |.|.....|.. .     | .|||||||  . | |.. ..|
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

IALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
||. | ..|..|||....  .|  . | | | |||. |. .. || . .
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 448-677 2.6e-24 80.4 In-house 50-294 (305) alignment 
Range on Protein: 448-677
Range on HMM: 50-294/305.0
KSANAHSNKNRSNNYLPPDKYIITLKD-TNDDYINASYLKG-YQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDE----DCCYQYWTGS---K
.||.    ||| ..    |. .. |.. .  ||| | |.      .| || || |...|. ||| |... ||  |||||         | |||  .   |
qsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

T--HGEFSIEVIS-KKIANGYTE---RNLKISF-DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNrqKKGPVVVHCSDTVSRSGVYCSVSIALEQ
   ..   .| .|  |  .  .|     |....  ... || .|| |.||. ||     | |...  .|    | |.|||||  . |.|   ..   ||.
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..skvpivvhcsagigrtgtivaieyilek

CKA-EGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTTYK
         . .. |..|  .  .. .  ||  |. |.  |.   ||
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 448-586 1.4e-17 58.5 In-house 28-180 (297) alignment 
Range on Protein: 448-586
Range on HMM: 28-180/297.0
KSANAHSNKNRSNNYLPPDKYIITLKD--TNDDYINASYLKGYQGKK--EFIIAQSPMENTVREFWKMIVDCKVSTIVMLC----GDEDCCYQYWTGS--
   |.   ||| .. |  |.  . |.   |. ||||| |.   . ..   .|.|| |...|| .||.....  | .|||..    .  | |. ||  .  
akrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

--KTHGEFSIEVISKKIANgYTE---RNLKISFDKESRSVLQLQVTDWPQDGVV
  .. |.. .| .|.   . .      .|.. . .||| |   |   ||. || 
erlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvp
0037934 (Phosphotyrosine protein) phosphatases II 449-671 1.2e-53 177.5 In-house 6-241 (243) alignment 
Range on Protein: 449-671
Range on HMM: 6-241/243.0
SANAHSNKNRSNNYLPPDKYIITLKDtnDDYINASYLKGYqgkKEFIIAQSPMENTVRE----FWKMIVDCKVSTIVMLCGDE----DCCYQYWTGSKTH
.  .. .|||  ..|| |   . |..  .|||||.. ...   . .|. | |...|| .    ||.|. . ....||||. ..      |.||| |..|.
llpenlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevty

GEFSIEVISKKIANGYTERNLKISF---DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVR----------NRQKKGPVVVHCSDTVSRSGVYCSVSI
|.|.....| .  ..|| |.|...    |...| | ... . ||  ||      .|. ...||          .. ..|||.||||  |.|.|...   .
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

ALEQCkaeGiVDVFQVTKTVRRTKPG-AVTTLEQYNSIYDVINLY
 |...   | ||.... |..|. .|| ||.|..||  .|...  .
mllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 449-668 2e-27 90.6 In-house 52-279 (290) alignment 
Range on Protein: 449-668
Range on HMM: 52-279/290.0
SANAHSNKNRSNNYLPPDKYIITLKDTND-DYINASYLKGYqgKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGS----KT
 .|.. .|||  .    ||  . |||  | ||. | |.||   |  ||..| ....|| ..|.|... ||..|||||         | ||.        |
dkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

HGEFSIEVISKKIANGYT-ERNLKISFDKES--RSVLQLQVTDWPQDGVVRKAGTILQVINDVRnrQKKGPVVVHCSDTVSRSGVYCSVSIALeQCKAEG
 ||...    ..  .  .  . | .   ..     .  |..  ||.  |   . ..|...  .|  .  ||||||||  . |.| . .. ..| |.  .|
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievgl.qilldG

-IVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
  .|. .. ...|... ..|    ||  . ...
keldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 450-674 3.9e-56 185.4 In-house 43-282 (318) alignment 
Range on Protein: 450-674
Range on HMM: 43-282/318.0
ANAHSNKNRSNNYLPPDKYIITLKDT----NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED----CCYQYWT--GSKT
 ..  .||| .| |. |.  . |...    . |||||.|. ||. ||..| ||.|. .|...||.|. . . ..||||   |.     . .||   ||..
epvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrs

HGEFSIEVISKKIANGYTERNLKISFD--KESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ---KKGPVVVHCSDTVSRSGVYCSVSIALEQCKA
.|.  .|. ...  . |. |..|.. .  .||| | | ..|.||. ||  .....|... .|.. |   ..||.|||||  | | ||.. |.| ||. ||
ygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerika

EGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
|..|||||. |..|. ..  | | .||. ||||.  ....
ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPRK_pd Subfamily PTPRK 450-668 1.8e-52 173.1 In-house 40-273 (314) alignment 
Range on Protein: 450-668
Range on HMM: 40-273/314.0
ANAHSNKNRSNNYLPPDKYIITLKDT----NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG-DEDC---CYQYWTG-SKTH
 . . .||||.. |..|.  ..|. .    . |||||... .|.  ..||..| |...||..||... | . ..||||    |     |..||   ....
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevy

GEFSIEVISKKIANGYTERNLKISF----DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR--QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKA
|.. .|... .. . .  | ....      .| | | |.| . ||. .|  .| ..|...  | .   ...|..|||||    |.|... ..| |.  . 
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmier

EGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
||.||||.. ||.| .|.  | | |||. |||||
egvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 450-674 4.1e-35 115.9 In-house 33-279 (287) alignment 
Range on Protein: 450-674
Range on HMM: 33-279/287.0
AN--AHSNKNRSNNYLPPDKY---IITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC-GDE---DCCYQYWTGSKT-
|.  |  .|||  . || |.    . .  .   ||||| |. .|. ...|| ||.|.  |||.||..... ........    |     ||.||   .  
aeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevP

--HGEFSIEVISKKIAN-GYTERNLKIS-FDK-ESRSVLQLQVTDWPQDGVVRKAGT----ILQV---INDVRNRQKKGPVVVHCSDTVSRSGVYCSVSI
   | .|. .....| .  |. | |..   .  |.| | ||.. .||....   |      .|.|   |.  |. .. ||.|||..  . |||.. .. .
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

ALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
 ... .  | ||| .|   .|  . . | .  |.  .|. .  | .|
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 451-671 1.1e-15 52.4 In-house 33-269 (285) alignment 
Range on Protein: 451-671
Range on HMM: 33-269/285.0
NAHSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGY-QGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC-----GDEDCCYQYWT--G-SKTHG
.|  . ||  .    ..  . ||. . ||| ||...   . .  .| .| |. .|. .||.|| . |.. ..|||     | | |.  |    |     |
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

EFSI-------EVISKKIANGYTERNLKISfDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR-QKKGPVVVHCSDTVSRSGVYCSVSIALEQCK
.. |       | |.  | |  |  | . .   |   . ..||  ||..     |  .... . |..   |. |..||||  | |.  .  .  |  .  
kyeitlteckeeaiagtilnaltvinteda.sseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirim

AEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLY
 .  ...... . .|  .  || .  |.  .| |.  |
enpniemldivremramrfqavqshmqflflyvvlmey
subfamily_PTPRD_pd Subfamily PTPRD 452-674 4.6e-61 202.1 In-house 47-283 (564) alignment 
Range on Protein: 452-674
Range on HMM: 47-283/564.0
AHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDE----DCCYQYWTGS--KTHG
|  .||| .| .. |.  . |. ..     ||||||...||. .|..| .| |...|...||.|. . ..||||||   |    . | .||  .  .|.|
aNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetyg

EFSIEVISKKIANGYTERNLKI--SFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR--QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGI
|. ... ...  . |. |..|.  . ..||| | | . |.||. ||  .| ..|..|..||.   ...||.|||||  | |.|... ... ||. |.|. 
eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeekt

VDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
||..|. |..|. ..  | | |||  |...|. ... 
vDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 452-674 9.2e-60 196.9 In-house 8-244 (250) alignment 
Range on Protein: 452-674
Range on HMM: 8-244/250.0
AHSNKNRSNNYLPPDKYIITLKDTN----DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG---DEDCCYQYWT--GSKTHGE
.  .|||  .... |.  . |. ..     ||||||.|.||...| ||..|.|...|. .||.|... |..|||||      |  . |||   .....|.
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGd

FSIEVISKKIANGYTERNLKISFDKESRS--VLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKK---GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGI
  ... ||..   || |.||.|  |.. .  | ||. . ||  || ..| ..|.....|.  |..   .||.|.||  |.||| .. ..  ||. | | .
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv

VDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQT
||||.| |..|. .|.||..|||| ..| .|  ....
vdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 452-675 1.2e-42 140.8 In-house 19-267 (270) alignment 
Range on Protein: 452-675
Range on HMM: 19-267/270.0
AHSNKNRSNNYLPPDKYIITLKDTND----DYINASYLKGYQGK-KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGSKTH--
 ... ||... ||  .  ..|.. ..     |||| |..|..|. |..| |..|...|...||.||.. ||..|||. |      . | .||. .. .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

----GEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAG------TILQVINDVR---NRQKKG-PVVVHCSDTVSRSGVYCSVS
    |. .. ..|.. ..||  ..|..  . |.| ..  . ..||..||.|...       .|.....||   ....|. |..||||. | |.|.   . 
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

IALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYIQTT
||..  . .. ||| .. . .|. ..  | . |||. .| .. .|....
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 453-672 4.5e-51 168.7 In-house 51-284 (297) alignment 
Range on Protein: 453-672
Range on HMM: 51-284/297.0
HSNKNRSNNYLPPDKYIITLKDTNDD----YINASYLKGYQGkkEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED---CCYQYWT--GSKTHGEF
  .|.| .| || |.  ..|. .|||    |.|||..||..   ..|  | ||..|| .||.|..| .|||||||  |..    | .||.  |..| |. 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdv

SIEVISKKIANGYTERNLKISFDK--ESRSVLQLQVTDWPQDGVVR--KAGTILQVINDVRNR---QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG
|... | .  .|. .|.|... .|    | | | | ..||.. | |  .| ..|..|..||.    ...||..|||.  | | ||....   . . | | 
svvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrek

IVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
 ||.|.. | .|. .|  | | |||. .| ... ..
evdifglvkklrqerpylvqtkeqykfvyvavleal
0049772 (Phosphotyrosine protein) phosphatases II 453-675 4.8e-27 90.9 In-house 46-283 (314) alignment 
Range on Protein: 453-675
Range on HMM: 46-283/314.0
HSNKNRSNNYLPPDkYIITL---KDTNDDYINASYLKGYqgkKEFIIAQSPMENTVREF----------WKMIV--DCKVSTIVM---------------
. .|||. . || |     |      . |||||||..|.   . ||..| |.|.||  |          |.|..  | .| .|||               
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCG---DEdccyqywtgS----------KthgefsieviskkiangyTERNLKISFdkeSRSVLQLQVTDWPQdGVVRKAGTILQVINDVRNRQ
      |..              .          |                  .| . .  |   .| ....  ...|  | .     ...... ... .
AlgKtpllildgng.........neptaadlellk..................eelydpelf...erlgikylripvpD.gsaplledfdeflefieead

KKGPVVVHCSDTVSRSGVYCSVSIALEQCKaegiVDVFQVTKTVRRTKP-----GAVTTLEQYNSIYDVINLYIQTT
|.|||.|||.. ..|.|... . . . ...    |.. .. . ||.. |     |.. .||||  |..... |... 
kggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 453-672 3.9e-22 73.6 In-house 43-271 (288) alignment 
Range on Protein: 453-672
Range on HMM: 43-271/288.0
HSNKNRSNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG-----DEDcCYQY---WTGSKTHGEFS
 . ..| .|    |   . |.|  | ||.|  .   . |. .| ||.|.. |. |.|||...  |  |||||       |    .|     | |..    
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkek.saeyfPsklGekarigrl

IEVISKKIanGYTERNLKISFDKESRS------VLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKkgPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIV
  |. ||      .. .|.|  . |.       | .| . .|..|||  .  . |.... ... ||  |.|||.|  | |.|    . ||||. . .  .
ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk..PivvhssaGvGrtgtlililialeslrlddfl

DVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
 . .. .  |  .  |..|  ||  .. ..  ..
girsllaklreerfkaiqtemqylyvhrcvleel
Y_phosphatase Protein-tyrosine phosphatase 454-668 2.8e-65 215.4 Pfam-A 2-233 (235) alignment 
Range on Protein: 454-668
Range on HMM: 2-233/235.0
SNKNRSNNYLPPDKYIITLKDTN--DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYWT----GSKTHGEF
..|||....|| ||  . ||...   |||||.|.|||. ||.||..| |...|. .||.|... ||..||||. .|.     | |||     .|.|.|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

SIEVI-SKK-IANGYTERNLKISFDKES---RSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ--KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG
..|.  ..| . ..|| |.|... .||.   |.| ||..|.||. || ...  .|..|..|....  |.||||||||. |.|.|......|.|||..||.
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

IVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
 |||.|. |..|. .||.|..||||  .|..|
evdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 454-668 2.8e-65 215.4 In-house 2-233 (235) alignment 
Range on Protein: 454-668
Range on HMM: 2-233/235.0
SNKNRSNNYLPPDKYIITLKDTN--DDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYWT----GSKTHGEF
..|||....|| ||  . ||...   |||||.|.|||. ||.||..| |...|. .||.|... ||..||||. .|.     | |||     .|.|.|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

SIEVI-SKK-IANGYTERNLKISFDKES---RSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ--KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG
..|.  ..| . ..|| |.|... .||.   |.| ||..|.||. || ...  .|..|..|....  |.||||||||. |.|.|......|.|||..||.
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

IVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
 |||.|. |..|. .||.|..||||  .|..|
evdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 454-573 5.7e-12 40.0 In-house 49-171 (305) alignment 
Range on Protein: 454-573
Range on HMM: 49-171/305.0
SNKNRSNNYLPPDKYIITLKDT-NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDE----DCCYQYWTgSKTHGEFSIEVI
..|||  .    |.  . |. .   .|| | |.      | || .|.|.|.|  .|| | .. || .| |||         |..|.. || . ....|  
agknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfa.skdkdvlefeek

SKKIANGYtERNLKISFDKESRSVL
 .||.  . |   ...| |......
gqkisvkf.essvtlkfrkdakakv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 454-670 5.3e-10 33.4 In-house 48-277 (303) alignment 
Range on Protein: 454-670
Range on HMM: 48-277/303.0
SNKNRSNNYLPPDKYIITLKDTndDYINASYLKgYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDccYQYWTGSK---------THGEFS
 .|||  . .  |.  . | |.   || ||||.  . .|  |..| |.  |  .||.||.. ||  ...|  | .  |.   |              | |
mdknrfvdvicldhskvklsds..syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdse..ydklggdsvfprnqdflkfeers

IEVIS---KKIANGYTERNLKISFDKeSRSVLQL-QVTDWPQDGVVRK-----AGTILQVINDVRNRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAE
| |      ....|.. . | .|  .  .| |.. .  .||.. .  .        | |.   .|.  .  | |      . |.| ..    |    ..|
irvgefkrvelgdgwvlkvlsvsngd.yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhse

-GIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINL
   .|. .. ..||  .  ||  | |.  .| ..  
qasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 455-672 9.8e-49 160.8 In-house 45-276 (515) alignment 
Range on Protein: 455-672
Range on HMM: 45-276/515.0
NKNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLC----GDEDCCYQYWTG----SKTHGE
.||| .| || |.  . |     . . ||.||||.....  | .| .| | . .| .||..... .|.||.|.     ||   | .||      |   |.
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

FSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQ--KKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDV
...|..| .   | . |.|..  ...|| | | . |.||. || ... ..|..| .|.  .   . |...|||  | | ||..|.   . . |   .|||
ikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdv

FQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
|.. . .|. .|  | | |||  ||...  ..
fnfvtnirqkrpylvqtqeqyafiygavledl
0041856 (Phosphotyrosine protein) phosphatases II 455-672 1.8e-37 124.1 In-house 3-171 (182) alignment 
Range on Protein: 455-672
Range on HMM: 3-171/182.0
NKNRSNNYLPPDKYIitlkdtNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCgdedcCYQYWTgskthgefsieviskkian
.|||  ..||.|  .      . |||||... |..  ..||..| |. .|| .|..|. . ...|||.|.     ...||                    
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp...................

gyternlkisfDKESRSVLQLQVTDWPQDGVVRkAGTILQVINDVRNrqKKGPVVVHCSDTVSRSGVYCSVSIALEQckaeGiVDVFQVTKTVRRTKPGA
           ... | ..|.. . || .||     ..|. |..|..  ..|||.||||  |.|.|...   . ...    | |..... |.||. .||.
...........ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgm

VTTLEQYNSIYDVINLYI
|.|..||  ..... ...
vitpnqyfflqlallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 455-668 2.9e-36 119.9 In-house 5-235 (237) alignment 
Range on Protein: 455-668
Range on HMM: 5-235/237.0
NKNRSNNYLPPDKYIITLKD--TNDDYINASYLKGYQGK-KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGS---KTHGEFS
 |||  |    |.  . ||   .. |||||.||||..|  |..| || |.|..  .||.|. . | | |||| |    .|  |..||  .   ...| ..
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

IEVISKKIANGYTERNLKISFD---KESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNR----QKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGI
. .  |.    || | | .|     || | . | | | ||. || ... ..|.   .. ||    .. || ..|||  | |.|..  .   | |.| . .
vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkv

VDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
||...  ...   .|  . | .||  |...|
vdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 455-665 4.4e-29 96.3 In-house 10-234 (239) alignment 
Range on Protein: 455-665
Range on HMM: 10-234/239.0
NKNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGK-KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGSKT-HGEFS
 |||  | .  |.  . |    .|   ||||||||. |.|  | .| .|  .| .  .||.|. . .   |||| |     .  |.|||  | . . .. 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

IEVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKKG--PVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDV
. .   ..   |  | . .|   . | | | | ..| ||. || . | ..| .   . .    |  | |.|||  | |.| .  .   | |.| .  ||.
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdi

FQVTKTVRRTKPGAVTTLEQYNSIY
|.  |..|  .|  | | |||  |.
fnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 456-665 4.1e-29 96.4 In-house 10-233 (239) alignment 
Range on Protein: 456-665
Range on HMM: 10-233/239.0
KNRSNNYLPPDKYIITL----KDTNDDYINASYLKGYQGK-KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWTGSKT-HGEFSI
|||  | .  |.  . |    .|   ||||||||. |.|  | .| .|  .| .  .||.|. . .   |||| |     .  |.|||  | . . .. .
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv

EVISKKIANGYTERNLKISF--DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKKG--PVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVF
 .   ..   |  | . .|   . | | | | ..| ||. || . | ..| .   . .    |  | |.|||  | |.| .  .   | |.| .  ||.|
tlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdif

QVTKTVRRTKPGAVTTLEQYNSIY
.  |..|  .|  | | |||  |.
nyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 458-661 3.6e-12 40.4 In-house 42-277 (302) alignment 
Range on Protein: 458-661
Range on HMM: 42-277/302.0
RSNNYLPPDKYIITLKDTNDDYINASYLKgyQGKKEFIIAQSPM-----------------ENTVREFWKMIVDCKVSTIVMLCG----DEDCCYQYWT-
| . ..   | .  |.| ..|.|||  ||   .. ..|.|| ||                  .|.  .| .| . .|. .| ||.    .|  | .|.. 
rkslficepktmaklvdfkndfinanvlk..ldeikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd

---GSKTHGEFSIEVISKKI-ANGYTERN------LKIS----FDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRqkKGPVVVHCSDTVSRSGV
   |  . |..... .| |   . .|...      ..|      .|  ..|  |. . ||. |  ..| | |....       |  |.||||  | |.| 
kvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesy..kknvlvhcsaGvGrtGt

YCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQY
  ..   .. |. . . |. .. . ||. . ||| . .| 
lvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 459-523 2.7e-12 40.9 In-house 52-116 (347) alignment 
Range on Protein: 459-523
Range on HMM: 52-116/347.0
SNNYLPPDKYIITLKDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVML
.   | |.|   .  |  . |||||..|  . .||.|..| |. .|||.||||.   ||. .| .
trvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_eak_pd Subfamily eak 460-581 1.2e-08 28.8 In-house 58-190 (332) alignment 
Range on Protein: 460-581
Range on HMM: 58-190/332.0
NNYLPPDKYIITLKDT---NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDCC---YQYWTGSKT-----HGEFSIEVI
 . .| |.| . |  .   .. ||||| ..  .  ...|..  . |. |  ||.|... |  .||.|  | .     .. .   ||     .| . .|  
vkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverk

SKKIANGYTERNLKISFDKESRSVLQLQVTDWP
.    | .  |.|..|   |.  ||  .|  | 
efvkrniletrllelskGnethrvlhykvfGwt
0046846 (Phosphotyrosine protein) phosphatases II 470-672 3.1e-28 94.1 In-house 5-173 (176) alignment 
Range on Protein: 470-672
Range on HMM: 5-173/176.0
ITLKDTNDDYINASYLKGYQgkkeFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYWTGSKTHGEfsieviskkiangyternlkisf
..  | . |||||... |.     .|. | |...|. .|..|. . .....|.|. . .     |..||   ...|                        
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

dkesrsvlQLQVTDWPQDGVVRKaGTILQVINDVRNRQKKG-PVVVHCSDTVSRSGVYCSVSialeQCKAEGIVDVFQVTKTVRRTKP-GAVTTLEQYNS
        | ....||  ||      .|.... .|...|.| ||.||||  ..|.|...        .. |  ..|... ..||. .| |||.| |||  
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

IYDVINLYI
.|... |..
lyefellll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 470-667 2.6e-16 54.1 In-house 69-285 (310) alignment 
Range on Protein: 470-667
Range on HMM: 69-285/310.0
ITL---KDTNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD--E--DCCYQYWTG---SKTHGEFSIEVISKKiANGYTER
. |   |   .||| | |.|    .. || .| |.. |. .||.|| . .  .|..||    |    |  ||     ..|.|   .  .|.  .. .   
vklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeic

NLKISF-------DKESRSVLQL-----QVTDWPQDGVVR-KAGTILQvinDVRNRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKT
|| ..|       |..   . .|     .  .||. ||   |  |. |    .  . ..||.|||||  . | .| ... ..... .    ||. .|   
nlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq...rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevkte

VRRTKPGAVTTLEQYNSIYDV
.....   . |  ||  |  |
llksraiciqtelqyliidrv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 471-528 1.3e-08 28.7 In-house 54-111 (332) alignment 
Range on Protein: 471-528
Range on HMM: 54-111/332.0
TLKDTNDDYINASYLKGYQGKKEFIIAQSPMEN-TVREFWKMIVDCKVSTIVMlCGDED
. .| .||. |||.. ||  |  .|.||.|... |   ||.|. . | | |..  || |
apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilv.fgdid
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 473-675 4.3e-24 80.2 In-house 42-262 (290) alignment 
Range on Protein: 473-675
Range on HMM: 42-262/290.0
KDTNDDYINASYLKGYQGkKEFIIAQSPMEN-------TVREFWKMIVDCKVSTIVMLCGDED--------CCYQYWTGSK----THGEFSIEVISKKIA
|  ||||| |....  .|  ..|. ||| |.       |. .|| |. . ||  .||||  |.         | .|   |     . . ....  ||   
krfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeke

NGYTERNLKISFDKESR-SVLQLQVTDWPQDGVVRKAGTILQVINDVRnrQKKGPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGIVDVFQVTKTVRRTK
..  .|.| . ||.|    |   .. .| .  | ..  |.|..|. |.  ..| ||.||| | .||| .  .. ..       .| | . .| |..|. .
ddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PGAVTTLEQYNSIYDVINLYIQTT
  |.|. ...  .  .| |... .
alaitsalelafvdagivllaiev
subfamily_CG42327_pd Subfamily CG42327 473-602 1.8e-11 38.3 In-house 52-193 (319) alignment 
Range on Protein: 473-602
Range on HMM: 52-193/319.0
KDTNDDYINASYLKGYQGK-KEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD-ED---CCYQYWTGSKT------HGEFSIEVISKKIANGYTERNL
.| .| |..|||..||.     .| || ..|..  .||... . .  .|| |.   |     | .|.  ..|      .|.. . .  ... . |    |
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl

KIS-FD-KESRSVLQLQVtDWPQDGVVRKAGTILQVINDVRNR
 .   | .||| .      .|.. .|  .  ... .. .||. 
llkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0043147 (Phosphotyrosine protein) phosphatases II 475-665 1.9e-31 104.5 In-house 3-154 (172) alignment 
Range on Protein: 475-665
Range on HMM: 3-154/172.0
TNDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDedccyqywtgskthgefsieviskkiangyternlKISFDKESRSVLQ
 ..||||||||..|   ..||. | |. ||. .||.|. . ....||.|..                                        ....|...|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................lydpellerlgiq

LQVTDWPQDGVVrKAGTILQVINDVRN---RQKKGPVVVHCSDTVSRSGVYCSVSIALeqckaEGIvDVFQVTKTVRRTKPGAVTTLEQYNSIY
.. . ||  ||   .  .|.... ...   ....|||.||||  |.|.|. .   . |     .|. ..... ..||. .||||.. .||. .|
ylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 475-536 1.5e-09 31.6 In-house 88-155 (349) alignment 
Range on Protein: 475-536
Range on HMM: 88-155/349.0
TNDDYINASYLKGY--QGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDC----CYQYWTG
  |||||| |||    . .| .|  | |.  || .|.|.|.  .|  .. |  |..     |..||  
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_egg_pd Subfamily egg 476-672 1.1e-22 75.1 In-house 67-270 (307) alignment 
Range on Protein: 476-672
Range on HMM: 67-270/307.0
NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGD--EDCCYQYWTGSKT------HGEFSIEVISK--KIANGYTERNLKI-S
 ||.| | ..||     |||.||.|. ||| .||.|.   .|  ||||      . |  ||  ...       | . || .    |    ..  .||.  
lddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG

FDKESRSVLQLQvTDWPQDGVVRKAgtiLQVINDVrnRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIV--DVFQVTKTVRRTKPGAVTTLEQYN
 |.| | .   |  |. . . |      |.|.  .  |.   ||||.. . ||....  .. ||| .     |.   | .  . .|. .. .| .  .| 
gddeerflehwq.gdvnnssdvysp...lrvlrkl..rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllyl

SIYDVINLYI
 .| .. ...
fvyrlvlfff
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 476-586 9.6e-11 36.1 In-house 12-127 (130) alignment 
Range on Protein: 476-586
Range on HMM: 12-127/130.0
NDDYINASYLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDcCYQYWTGSKTHG--EFSIEVIS-K-KIANGYTERNLKISFDKES--
...|||||..   .  .|.. .| |. .|  .||||...  |  .|.|   |.   .||  |.     |  | | . . .  .     ||.|. |     
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.edeywpdsePlewyeediivtltdrdefknikasnleiesdlnesh

RSVLQLQVTDWPQDGVV
...  .|...|| ||  
qaltmfqisnwpsdgtt
0051429 (Phosphotyrosine protein) phosphatases II 477-672 5.7e-36 119.9 In-house 4-225 (272) alignment 
Range on Protein: 477-672
Range on HMM: 4-225/272.0
DDYINASYLKGYQG---KKEFIIAQSPMENTVREFWKMiVDCKVSTIVMLCGDE----DCCYQYWT--------------GSKTHGEFSIEVISKKIANG
..||||....|| .   .. .. .. |...|...||..  . ...|||.|...|    . |..||                . ..| ... ..|... . 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTERNLKIS---FDKESRSVLQLQVTDWPQDGVVRKAgtILQVINDVRNrqkKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVD--------VFQVT
|. |.| ..     .|.| |..|. |||| .|| ..|  .|.... ...   .|||.||||  ..|.|... . . |..  .| |||        .... 
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

KTVRRTKPGAVTTLEQYNSIYDVINLYI
. .|.  |||| | |||  .|...  ..
eelraqrpgavqteeqylflyeallell
0036282 (Phosphotyrosine protein) phosphatases II 477-666 8.1e-32 105.7 In-house 2-164 (174) alignment 
Range on Protein: 477-666
Range on HMM: 2-164/174.0
DDYINASYLKGYQGKKEFIIAQSPMEntvreFWKMIVDCKVSTIVMLCGDED----CCYQYWTGskthgefsieviskkiangyternlkiSFDKESRSV
.||||||.|...   ...|. | |..     ||.|. . ...|.|||.  .      |..||                               . ..|..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlg

LQLQVTDWPQDGVVRKAGtILQVINDVRNRQK---KGPVVVHCSDTVSRSGVYCSVSIALEQCKaEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYD
.|.. . || .||   .  .|.... |.. ..   .|||.||||  |.|.|. .   . | . . |. ||.... ...|. .||.|.| .||  .|.
iqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 477-667 2.7e-25 84.1 In-house 3-148 (151) alignment 
Range on Protein: 477-667
Range on HMM: 3-148/151.0
DDYINASYLKGYqgkkeFIIAQSPMEntvrEFWKMIVDCKVSTIVMLCGDE--DCCYQYWTGSKthgefsieviskkiangyternlkisfdkesRSVLQ
.||||.||. |.     ... . |..    .|.... . ...|||.|...|  . |..|..                                  . ||.
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...............................ievlh

LQVTDWPQDGVVRKAGTILQVINDVRNrQKKGPVVVHCSDTVSRSGVYCSVSIALEQckaegiVDVFQVTKTVRRTKPGAVTTLEQYNSIYDV
....|||  |.     ..|.... ... .|.|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
ipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0044763 (Phosphotyrosine protein) phosphatases II 477-669 1.6e-19 65.7 In-house 18-168 (178) alignment 
Range on Protein: 477-669
Range on HMM: 18-168/178.0
DDYINASYLKGYqgkkeFIIAQSPMentvREFWKMIVDCKVSTIVMLCGDEDCC----YQYWTGSKThgefsieviskkiangyternlkisfdkesRSV
 ||||||.  ..     ..... |.     ...... . ....||.|...  .     ..||  .                                  .
sdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................iqy

LQLQVTDWPQDGVVRKAGTILQVINDVRNrQKKGPVVVHCSDTVSRSGVYCSVSIALEQckaeGIvDVFQVTKTVRRTKPgAVTTLEQYNSIYDVIN
|.. . |..   . .    ... |..... .|.|||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.. .|..  
lhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 484-668 2.7e-25 83.6 In-house 228-434 (440) alignment 
Range on Protein: 484-668
Range on HMM: 228-434/440.0
YLKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED-CCYQYW---TGSKTHGEFSIEVISKKIANGYTERNLKISFDKESRSVLQLQVTD
 ..||  |. || .| |.. || .||... | ..|||.||   .|  |  ||   | | | | |..     .  |    | |.. . .|   . |..|  
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqt

WP----QDGVVRKA---GTILQVINDVRN----------RQKKG-PVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQY
||     |||  .     ..||... .|.          |   | |..|||   .  |||.|.|   ||| . .| .||||  . .| ..|  | || .|
wptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdy

NSIYDVI
   | ..
llcykll
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 484-673 6.8e-07 22.2 In-house 107-310 (346) alignment 
Range on Protein: 484-673
Range on HMM: 107-310/346.0
YLKGYQGKKEFIIAQSP-MEN--TVREFWKMIVDCKVSTIVMLCGDEDCC-------YQYWTGSKTHGEFSIEVISKKIANGYTERNLKISFDKESRSVL
|.  .| ....|.|| | |||   | .|| || . ..  . ..  |.           .   | .  | . |.     ..    |  ...  . .| ||.
yfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvi

QLQ--VTDWPQDGVVRKAGTILQVINDVRNRQKKGP--VVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVIN
      . | .     |.  |...| .    ..     | |       |.  .     |..|       ..... |.... .||.| .. || ||| .. 
cqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf

LYIQ
 || 
dyia
0049260 (Phosphotyrosine protein) phosphatases II 485-666 6.1e-25 83.1 In-house 2-144 (152) alignment 
Range on Protein: 485-666
Range on HMM: 2-144/152.0
LKGYQGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDED----CCYQYWtgskthgefsieviskkiangyternlkisfdkesrsvlQLQVTDW
..||  ..|||..| |..||. .||.|. . ...|||||. ...    .|.||.                                       | . . |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlpw

PQDGVVRKAGTILQVINDVRN--RQKKGPVVVHCSDTVSRSGVYCSVSIALeqckaeGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYD
| .||   .  .|...  ..   ..|.|||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 489-667 9.6e-18 59.1 In-house 2-199 (199) alignment 
Range on Protein: 489-667
Range on HMM: 2-199/199.0
QGKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDCCY----QYWT--GSKTHGEFSIEVISKKIA--NGYTERNLKISFD----KESRSVLQLQ
.|.. .| .| |. .|. .||.|. .     |||.  |.         ||    | |    |. | .| |.    ||   | .. .      .| . . |
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VTDWPQDGVVRKAGTILQVIN-----DVRNRQKKGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDV
 | | .      |  .  |.         ...|  ||.|||||    .||. .. | .    . |   .||.|.|.| .|... | ...|..|| ||.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 490-667 1.4e-17 58.6 In-house 2-198 (198) alignment 
Range on Protein: 490-667
Range on HMM: 2-198/198.0
GKKEFIIAQSPMENTVREFWKMIVDCKVSTIVMLCGDEDCCY----QYWT--GSKTHGEFSIEVISKKIA--NGYTERNLKISFD----KESRSVLQLQV
|.. .| .| |. .|. .||.|. .     |||.  |.         ||    | |    |. | .| |.    ||   | .. .      .| . . | 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGVVRKAGTILQVIN-----DVRNRQKKGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDV
| | .      |  .  |.         ...|  ||.|||||    .||. .. | .    . |   .||.|.|.| .|... | ...|..|| ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 496-655 1.7e-09 32.2 In-house 39-204 (255) alignment 
Range on Protein: 496-655
Range on HMM: 39-204/255.0
IaqspmenTVREFWKMIVDCKVSTIVMLCGDED----CCYQYWTGSKTHGE--FSIEVISKKIANGYTERNLKI--SFD--KESRSVLQLQVTDWPQDGV
.       || .|...||  | ...||||  ..     | .|.   |        ..|.. | ..    | |.|   .   |. . |   . . |..   
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

VRKAGTILQVINDVRNRqKkgPVVVHCSDTVSRSGVYCSVSIAL-------EQCKAeGIVDVFQVTKTVRRTKPGAV
 . |  ||...  ||.  |  .||||||  . ||  .  . ..        .. .. . .|  .. . .| ....|.
Pelareilnilkvvrds.k..svvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkrai
subfamily_hpo-7_pd Subfamily hpo-7 501-657 1.1e-08 29.3 In-house 43-212 (263) alignment 
Range on Protein: 501-657
Range on HMM: 43-212/263.0
MENTVREFWKMIVDCKVSTIVMLCGDED----CCYQYWTGSKTHGE--FSIEVISKKIANGYTERNLKIS--FD--KESRSVLQLQVTDWPQDGVVRKAG
. .|. .|...||  | ...||||  ..     | .|.   |        ..| . |. .    . |..   ..  |. . | . . . |..   ...| 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

TILQVINDVRNRqKkgPVVVHCSDTVSRSGVYCSVSIALE-------QCKAeGIVDVFQVTKTVRRTKPGAVTT
 ||.... .||  |  ..|||||  . ||  .  . ..         . .. . .|  .. . .| ....|. |
eilnilkvarns.k..slvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraiht
0048179 (Phosphotyrosine protein) phosphatases II 513-666 9.5e-14 46.8 In-house 26-139 (144) alignment 
Range on Protein: 513-666
Range on HMM: 26-139/144.0
VDCKVSTIVMLCGDEDCCYQYWTgskthgefsieviskkiangyternlkisfdkesrsVLQLQVTDWPQDGVVRKAGTILQVINDVRNR-QKKGPVVVH
 . ...|.. |. . .  .   .                                    ..|.. ..||  ||   .  .|.... ...  ...|||.||
kklgittvinlteeyepeflere....................................giqylhlpwpDhgvpdllellleflefieealeeggpvlVH

CSDTVSRSGVYCSVSIALeqckAEGiVDVFQVTKTVRRTKPGAVTTLEQYNSIYD
||  |.|.|...   . .     .| ...... . ||.  ||||.. .|.. ...
CsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 557-669 2.6e-15 51.9 In-house 32-140 (145) alignment 
Range on Protein: 557-669
Range on HMM: 32-140/145.0
TERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQK-KGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGiVDVFQVTKTVRRTKPGAV
|  ||   .. ..| ..|.. ..||  ||   . ..|.... ... .| .|||.||||  |.|.|...    |.  .. .| |..... . ||.  ||||
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgav

TTLEQYNSIYDVIN
.. .|.. .|... 
pnpgqlrflyefel
DSPc Dual specificity phosphatase, catalytic domain 558-623 4.5e-06 21.6 Pfam-A 28-91 (133) alignment 
Range on Protein: 558-623
Range on HMM: 28-91/133.0
ERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVrnRQKKGPVVVHCSDTVSRSGVYC
| . .... |...  |...| |  .. ....   . ..|...  .||.. |.|||   .|||.  .
evpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatli
DSPc Dual specificity phosphatase, catalytic domain 558-623 4.5e-06 21.6 In-house 28-91 (133) alignment 
Range on Protein: 558-623
Range on HMM: 28-91/133.0
ERNLKISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVrnRQKKGPVVVHCSDTVSRSGVYC
| . .... |...  |...| |  .. ....   . ..|...  .||.. |.|||   .|||.  .
evpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatli
subfamily_DSP12_pd Subfamily DSP12 563-623 5.8e-07 24.0 In-house 42-100 (155) alignment 
Range on Protein: 563-623
Range on HMM: 42-100/155.0
ISFDKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVRnrQKKGPVVVHCSDTVSRSGVYC
 . .|   | ...|..| |.  ...   .... |.. .  ...| |.|||   ||||   .
hklkkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiv
PTPc_motif_SM00404 566-645 6.8e-06 21.0 In-house 43-121 (140) alignment 
Range on Protein: 566-645
Range on HMM: 43-121/140.0
DKESRSVLQLQVTDWPQDGVVRKAGTILQVINDVrnRQKKGPVVVHCSDTVSRSGVYCSV-SIALEQCKAEGIVDVFQVTK
 .... .||... |  .| ....   .|..|...  ..|.| |.|||   ||||.  . .  .  .|....  ...... .
ensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 570-673 8.5e-11 36.1 In-house 186-288 (305) alignment 
Range on Protein: 570-673
Range on HMM: 186-288/305.0
RSVLQLQVTDWPQDGVVRKAGTILQVINDVrnRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIV-DVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
| | .    |||. ||     .||.....   |  |||.|||||  . |.|    .   |.|  |  |. |  .. . .|  .  .. | .||  ...||
rkvthyhwidwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi

NLYIQ
  |..
lnyfr
subfamily_DSP19_pd Subfamily DSP19 571-653 1e-06 23.2 In-house 57-138 (152) alignment 
Range on Protein: 571-653
Range on HMM: 57-138/152.0
SVLQLQVTDWPQDGVVRKAGTILQVINDVRNRQkkGPVVVHCSDTVSRSGvycSVSIA--LEqCKAEGIVDVFQVTKTVRR---TKPG
 .|.... | |.  ...   ..|. |...|. .  | |.|||.  ||||    || ||  ..  .   . . ... ...|.      |
tylsieilDlpetdllsylkealdFieearskd..gavlvHCnAGvSRsa...svviaylmk.keelsleealelvrearpcikPneG
PTPc_DSPc_SM00012 572-668 2.2e-24 81.0 In-house 2-103 (105) alignment 
Range on Protein: 572-668
Range on HMM: 2-103/105.0
VLQLQVTDWPQDGVVRKAGTILQVINDVRNRQKK----GPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GIVDVFQVTKTVRRTKPGAVTTLEQYNSIYD
| ....|.||. || ...  ||.....|.. ..|    .|||||||. |.|.|... ..|.|.|...| . ||.||. | .|. .||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_DSP1_pd Subfamily DSP1 574-663 1.5e-06 22.4 In-house 66-154 (163) alignment 
Range on Protein: 574-663
Range on HMM: 66-154/163.0
QLQVTDWPQDGVVRKAGTILQVINDVRNrqKKGPVVVHCSDTVSRSGVYCSVSI-ALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNS
.|.. | |.. .     .... |..|..  |.| | .||   .|||   | . .   .... |   |  .  ... .   | |  | .|..
klkleDspkadislvfeeviefidevkk..knGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
subfamily_CG42327_pd Subfamily CG42327 601-672 1.5e-13 45.1 In-house 243-315 (319) alignment 
Range on Protein: 601-672
Range on HMM: 243-315/319.0
NRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVINLYI
.|...||.|||||| | |.|.  .  ||... .     ||. |.   ||| .  || | |||. || |.  | 
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 601-668 2.5e-09 31.4 In-house 224-291 (297) alignment 
Range on Protein: 601-668
Range on HMM: 224-291/297.0
NRQKKGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
.  .. ...||||  | ||||     . |.. . . | ||  . . .|  ..  | ||||.. .||..
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 609-667 1.9e-07 25.4 In-house 2-60 (69) alignment 
Range on Protein: 609-667
Range on HMM: 2-60/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDV
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 609-668 5.7e-07 23.8 In-house 1-60 (69) alignment 
Range on Protein: 609-668
Range on HMM: 1-60/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGIVDVFQVTKTVRRTKPGAVTTLEQYNSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal