Gene PTPRD-4 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP095_AA protein Get Run
AqueP095_AA_1025-1306 phosphatase_domain Get Run
AqueP095_AA_1312-1568 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ig_2 Immunoglobulin domain 150-225 4.9e-10 31.3 Pfam-A 11-73 (80) alignment
Range on Protein: 150-225
Range on HMM: 11-73/80.0
MSLNSSFVLNCTDDsGDPLSTFQWFKDDINITASTNPqlsitqytdrisyLTVTNVSPELAGSYKCATNN-GIGKSQ
.. .....|.|. . |.|  ..|| ||.  .. |.|              | . |||.| .|.| | . | . .|. 
vtegenvtLtCqap.gnptpkvqwykdgeelsqsqna.............lfipnvsaedsGtYtCrasnsegskqs

I-set Immunoglobulin I-set domain 150-230 9e-10 30.2 Pfam-A 12-88 (90) alignment
Range on Protein: 150-230
Range on HMM: 12-88/90.0
MSLNSSFVLNCTDdSGDPLSTFQWFKDDINITASTNPQLSITQytdRISYLTVTNVSPELAGSYKCATNNGIGKSQAVADI
.| ..|  |.||  .|.|  ...|.||. ... | . ... ..    .. ||..||... .|.|.|  .| .||..| | .
vseGesvelectv.eGepepsvsWakdgselkssqrvkvtvee...aeytLtIsnvevsDeGkYtckatnsagkaeakaeL

I-set Immunoglobulin I-set domain 243-332 7.3e-08 24.1 Pfam-A 7-90 (90) alignment
Range on Protein: 243-332
Range on HMM: 7-90/90.0
PLNSSVPVGQSIQLLVHFIGGyPLPTVTWYRLlG-ITN-SNRVPITDPRasasgqYSLNLTITNSSLSDDGLYLLMINNTIGAIEIEFNVTI
. .  | .|.|..| ..  |  | |.|.|..  |  .. |.|| .|          .  |||.| . || | | . ..| .|  | ......
lkdvevseGesvelectveGe.pepsvsWakd.gselkssqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

V-set Immunoglobulin V-set domain 245-320 3.3e-06 17.9 Pfam-A 10-101 (114) alignment
Range on Protein: 245-320
Range on HMM: 10-101/114.0
NSSVPVGQSIQLLVHFIggY--PLPTVTWYRLLG------IT-------NSNRVPITDPRAS--ASG-QYSLNLTITNSSLSDDGLYLLMINNT
  .| .|.|. | ...   .     ...||.         |.       ||.  .  . | .  ..| .....|||.| .|.| |.| ... ..
pvtvaeGgsvtLpCfys..ssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds

0050432 (Phosphotyrosine protein) phosphatases II 1021-1307 1.3e-92 305.8 In-house 24-301 (308) alignment
Range on Protein: 1021-1307
Range on HMM: 24-301/308.0
EHVGRDEFQEHVEKldKNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLqeipGvPHSHYINANFIKGY--HDDKLYIATQ
...  ... ...||  ..   ...| || ..|. |.. .  | |...  ..||||.|. ..||.|| |    . ..|.||||....||  . .. .||||
lklsvldllkllek..aldlglleeefeellsvkplley..svallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatq

GPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS---GQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTteKERTVLQFHYTAWPDRNV
||...|..|||||||||.. .|||||.|.|  . ||.||||..   |  .||.. |.. .  .|..||.| ... | .|   ..||| .||||.||| .|
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgv

PAQASHVLDFLRAINSANDKeeyGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVY
| .....||||..... ...   ||||||||||||||||.||||..||||. |..||. ..| .||.|| .||| . ||.|.. |.|| . .
Ppspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1022-1320 5.4e-189 623.2 In-house 1-294 (439) alignment
Range on Protein: 1022-1320
Range on HMM: 1-294/439.0
HVGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPK
||||||||||||||||||||||.||||.||||||||||||||||.|||||||||.|||||||||||||||||||||||||||.||||.||||||||||||
hvgrdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

EETTDDFWRMVWEQRTVTIVMLTNLMESYKskchqYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASH
.||||||||.|.|..||||||||||.||||     ||||....||||||||||||||||.|.||||||||||||||||||||||||.||||.||||||||
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

VLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDR
|||||||||||||||||||.||||||||||||||||||||||||||||||||||||..|||||||||||||||.||.||.||||||||.|||||||| .
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke

0051299 (Phosphotyrosine protein) phosphatases II 1022-1303 1.9e-96 318.2 In-house 4-284 (288) alignment
Range on Protein: 1022-1303
Range on HMM: 4-284/288.0
HVGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPK
..  .|. ..|.|| .| . .. | || . |  ||. .  | |...  ..||||.|. ..||.|| |. ..||..| ||||..|.||. .. .||||||.
eisveellklvlkllangltglleefeellsllpdltl..saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

EETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNE--RDTTEKERTVLQFHYTAWPDRNVPAQA
..|..|||||||||.. .|||||.|.|  . ||.||||..|  .|||| |.  .  .|..||.| ..| |    | ....||| .||||.||| .||  .
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

SHVLDFLRAINSANDkEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
...|||||....|.     ||.|||||||||||||.||||..||||. |..||. ..| .||.|| .||| ..||.|.. |.||
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

subfamily_PTPRB_pd Subfamily PTPRB 1023-1303 2.6e-95 313.8 In-house 7-283 (293) alignment
Range on Protein: 1023-1303
Range on HMM: 7-283/293.0
VGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKE
.  ..|.|||.|. .. .  |.| .| ...   | |. |  | .. ...||||... ..||.|| |... . ..| |||||.|.||.  . .||||||  
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavka..aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS-GQCCYGDIAVRVDRNIELPHYTIRGFKVFNerdtTEKERTVLQFHYTAWPDRNVPAQASH
||.|||||||||... .|||||.|.|  | ||..|||.   .. |||| | .  . || ...|| .|. .    ...||.| |.|.|.||| .|| ... 
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektkt

VLDFLRAINSAN-DKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
.|||.|....|  .... .||||||||||||||| ||||  |.... |. ||| |||. ||..|...||.  ||||||...|.
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld

subfamily_Ptp69D_pd Subfamily Ptp69D 1023-1324 5.4e-91 299.9 In-house 4-305 (307) alignment
Range on Protein: 1023-1324
Range on HMM: 4-305/307.0
VGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKE
. .|. .| ... ... .. . . .| ....  |  .  . .... .. |||| |. |||.||| |..|.|  .| ||||.|||||.. | .|| |.| |
iaiddleealksrkrdtdfglakeyekLeareidkst..kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTT---EKERTVLQFHYTAWPDRNVPAQA
.| .|||||..||   .||||.|| |  . ||..|||   .. |||| |.. .. . ..|.|| ..| .  ...   |..| |.|.|||.|.| .|| .|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

SHVLDFLRAINSANDKEeYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKD
  .|.... ... . ..  .||||||||||||.|...|||. |.|||.|.||||  .|  ||.||. .|| | ||.|.. |.|. . |||| ...|...|
rgllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

RCMKL
.  .|
aierl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1023-1325 2.8e-84 277.9 In-house 4-303 (305) alignment
Range on Protein: 1023-1325
Range on HMM: 4-303/305.0
VGRDEFQEHVEKLDKNKQEIFNEIFEFINSTsPDYACIaslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKE
.. |........  ..... ... .. . .. ..   .     .| ...|||....  .|. |. |.| . ...|.||||....||.  | ||..||| .
ialddlaayikearvysdkgleaqykslyee.eesidv...gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

ETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC--CYGDIAVRVDRNIELPHYTIRGFKVFNERDtTEKERTVLQFHYTAWPDRNVPAQAS
.| .||||...| ...||||||.|.|  |.||.|||| | .    .|.. | .  . . . |..| .|. .|..  ...|||||.. | |||  || .|.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfat

HVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDR
 .|.... .. .  |..  |..|||||||||||. ||.|||||.|| |. ||. ...  ||..| .||| | || |.|.|. | |  ||| . .. .. |
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

CMKLQ
  ||.
vnklk

0043336 (Phosphotyrosine protein) phosphatases II 1024-1303 1.4e-86 285.7 In-house 3-275 (278) alignment
Range on Protein: 1024-1303
Range on HMM: 3-275/278.0
GRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPdyaCIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEE
.. ........| .| . .. . || ..|  .   .  | |...  ..||||.|. ..||.|| |. ..|...| ||||....||.  . .|||||| .|
svkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPsSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNerDTTEKERTVLQFHYTAWPDRNVPAQASHVL
|..||||||||... ||||||.|.|  . ||.|||| .|  .|||. |.. . ..|..||.| ..| |    . ..|||...||..||| .|| . |..|
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslslll

DFLRAINSANDkEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|||.|...|..  . ||..||||||||||||.|||...||||. | .||.  .| .||.|| ..|| . ||.|...|.||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_PTPN14_pd Subfamily PTPN14 1024-1303 9e-62 203.7 In-house 8-294 (300) alignment
Range on Protein: 1024-1303
Range on HMM: 8-294/300.0
GRDEFQEHVEKLDKnKQEIFNEiFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVpHSHYINANFIKGY--HDDKLYIATQGPK
 .|.  ...||  . . ..| | .| |   . |  .  | |. . .. |||..||  ....|| |.      .. ||||  ||      .. ||..||| 
tkdkrakilekkle.egkvfte.yeripkkredall..staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPl

EETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS----GQCCYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYTAWPDRNVPA
| |  |||.||||| .  |||||.  |. | |...|.|..     .  .|   |    . . . .. .|.|.  .   ...||||. . || |||..|| 
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglkl..khlpskeertvwhlqytDWpdhgvPe

QASHVLDFLRAINSAND--------KEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
  .. |..|. ..|           ||.  |..||||||||||| .|  |. .. |. ....||| ... ||.||  .||.|.|| |.......
DvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPRD_pd Subfamily PTPRD 1025-1334 1.1e-120 399.0 In-house 7-316 (564) alignment
Range on Protein: 1025-1334
Range on HMM: 7-316/564.0
RDEFQEHVEKLDKNKQEIFNEIFEFINSTsPDYAciASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEET
 .|..|||.||..|..  |.| .. |..  .      . |...  . |||| .. |.||.|| |....|.. |.||||.||.||. .| |||||||..||
vaelkehvaklkansdlkfeeeykkieeg.qqft..weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYTAWPDRNVPAQASHVLD
..|||||||||.. ||||||.| |. | |||.|||..|.. ||.. | .  . || .|.|| ||.  .. .... |.| |||.|.|||..|| .| ..||
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRAINSANdKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKL
..| ....| ... |||||||||||||||| |..|. ||..| |..||| ..|. |||||. |||  .||||||.|||| .  |.| |.....|.. .||
lirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

QEP------TLINEEF
.|       | .. ||
aeveedtemtgleleF

subfamily_PTPRA_pd Subfamily PTPRA 1025-1325 1.6e-95 314.8 In-house 16-315 (330) alignment
Range on Protein: 1025-1325
Range on HMM: 16-315/330.0
RDEFQEHVEKLDKNKQEIFNEIFEFINSTSpdYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEET
 ....| ...   .  . | | |. . ...    .   ||..| .. |||. ..  .|..|| |... ||..| |||| ||.||.. . .||.|||||||
vekleeeirirsaddnklfreefnalPagp..iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeet

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTT--EKERTVLQFHYTAWPDRNVPAQASHV
 .|||||.|||.. ||||||.| |  ..||.||||. |   ||.| | |. . .| .||.| | | .  |.|  .|.| | |||.|.|||  ||...  .
vedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm

LDFLRAINSANDKEEYgPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCM
|..|..... |...   ||||||||||||||| |.||  ||..| |.|||. ..|  ||.|| ||||.. || ||....||  .|||| . .  .. .  
lkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

KLQ
||.
kly

0045450 (Phosphotyrosine protein) phosphatases II 1025-1303 3.6e-86 285.0 In-house 11-302 (307) alignment
Range on Protein: 1025-1303
Range on HMM: 11-302/307.0
RDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGV-PHSHYINANFI--------KGYHDDKLYI
.  .  .| .| ..  ... . || ..|  ... .  | |...  ..||||.|. ..||||| |. ..|  ..|.||||...        .||. .. .|
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

ATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC-CYGDIAVRVDRNIELPHYTIRGFKVFNErDTTEKERTVLQFHYTAWPDRN
|||||..|| .|||||.|||.. .|||||.|.|  . ||.||||..|.  .||.. |.. .  .|..||.| ..| .  | |...||| .||||.||| .
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhg

VPAQASHVLDFLRAINSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENK---VDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||   ...|||......|...  . ||..||||||||||||.||....|.||. |..   ||.  .| .||.|| ..|| . ||.|...|.||
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1026-1327 2.4e-105 347.1 In-house 5-302 (318) alignment
Range on Protein: 1026-1327
Range on HMM: 5-302/318.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASlaAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETT
.....||..| .. .  ..| .| .. ..   . . |   .. ...|||| .. |.||||| ||.. |.. | |||||.| ||. .| |||.|.|  || 
edleshvrrlresGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpeti

DDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNerDTTEKERTVLQFHYTAWPDRNVPAQASHVLDF
.||||||||| . .|||||...|. | |.|.||||.|   ||.. | .. ..|| .|..| ||| .  . .|..|.| |.|||.|||..||......||.
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldl

LRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQ
.| ...|. |...|||||||||||||||. ||.|| ||..| |. ||. ..|. ||.||. |||.  ||.||....|| .  ||| |  .....|  .|.
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

EP
|.
eq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1026-1326 5.3e-99 326.3 In-house 8-304 (319) alignment
Range on Protein: 1026-1326
Range on HMM: 8-304/319.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDyacIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETT
.|..|....|... .  ... |. .. ...|     . | .| ...||||... |.|.|||.|.|..||. | ||||.|| ||.. . .||||.|.|.|.
qeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

DDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVfNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDF
.||||||||... ..||||.| |  | |...|||.     || . | .. . || .| || .|. |.. .  . |.| .|.||.||| .|| .|  .||.
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldl

LRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQ
|. |. . .|.. |||||||||||||||| |.||..||..|.|. .|.  .|  || ||. |||   ||.||..|.|| .  ||| . .....|| ..|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

E
|
e

subfamily_PTPRG_pd Subfamily PTPRG 1026-1322 9.6e-91 299.7 In-house 4-306 (563) alignment
Range on Protein: 1026-1322
Range on HMM: 4-306/563.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHS-HYINANFIKGYHDDKLYIATQGPKEET
.||..|| .|  . .  |.| || ..|.. .    |. . .. .. |||| .. |.|..||.|...||. ..  |||||.|.||.  | .|||||| ..|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFN----ERDTTEKERTVLQFHYTAWPDRNVPAQAS
.||||||.|||.. .|||.||| |. . ||..|||. .   || . |.  ..  |  ||.| ... |    . . ...|..| |.||| ||| .|| .. 
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

HVLDFLRAInSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKD-
 || | .   ||  |.| |||||||||||||||| |.||  |.|.. ||.|.. |..  .| ||  .||   ||||.|.|.|| |  ..| .. .. .. 
pvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveel

-RCM
  | 
knct

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1026-1304 1.6e-66 219.1 In-house 5-282 (290) alignment
Range on Protein: 1026-1304
Range on HMM: 5-282/290.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQEIPGVPH--SHYINANFIKGYHDDKLYIATQGPKEE
|.| |.|..  .. .| |.. |. ..|.. ...    |.    ....||....   |  |.||..|.| .    .|||| .||||...| ||||||| ..
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltss..nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTtEKERTVLQFHYTAWPDRNVPAQASHVL
|  |||...|....  |||||| .|. | ||.||||.|..  || . ...  . .| .|..| ..| |.. . .....| |.. |.|..    .. . .|
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtil

DFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILED
  .. ..  . |.  ..||||||..|||... .|....... | |  .|.  ..  .| |. ..||.  || .|.. .|. 
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1026-1311 1.2e-64 213.1 In-house 5-284 (287) alignment
Range on Protein: 1026-1311
Range on HMM: 5-284/287.0
DEFQEHVEKLDKNKQEIFNEIFEFINS-TSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQeipgVPHSHYINANFIKGYHDDKLYIATQGPKEET
..| | |.|  .. .| |.. |  ... |  .     ..| .  .. |||....   |  || |.      |  |||| ||.||...| .|....|  .|
ekfgefvakghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEkERTVLQFHYTAWPDRN-VPAQASHVL
  .||.......  .||||....|. ...|.||||..   ..|. ....  .    .|..| ..| |.  ... ...| |...|.|...  |. ... .|
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqtill

DFLRAINsANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTA
 . . .  .. |.  ..||||||..|||... .| ...... | |  .|.  ..   | |. ..||.  ||.|| ...|| .  ..| 
vieemyk.tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1026-1119 8.4e-10 32.7 In-house 8-95 (95) alignment
Range on Protein: 1026-1119
Range on HMM: 8-95/95.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASlaaHEYDQTKNRYRDVGAFDHTRVTLQEipgVPHSHYINANFIKGYHDDKLYIATQG
  |. || ..  | .. |.. |  |. ||     . |    | .  |||. ..  .| |||.|        | |||| |. ||   . |||.||
svfhshvlemhsnsdqefdnefksismtsgapytvgs...seanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

0039614 (Phosphotyrosine protein) phosphatases II 1027-1305 4.2e-87 287.6 In-house 18-289 (297) alignment
Range on Protein: 1027-1305
Range on HMM: 18-289/297.0
EFQEHVEKLDKNKQEIFNEIFEFINSTSPDyaciASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGV-PHSHYINANFIKGYHD-DKLYIATQGPKEET
 .  .. ....|.  .. . || . |  ||     | |...  ..||||.|. ..||.|| |. ..|| ..| ||||....||.  .. .|||||| .||
vldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

TDDFWRMVWEQRTVTIVMLTNLMESYKsKCHQYWPSSGQcCYGDIAVRVDRNIELPHYTIRGFKVFNerdtTEKERTVLQFHYTAWPDRNVPAQASHVLD
..|||||||||.. .|||||.|.|  . ||.||||..|. .|||. |.. . ..|..||.| ..| |    ....||| .|.|| ||| .||  ....|.
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellle

FLRAINSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
||.....|. .  . ||..||||||||||||.||....||||. | .||.. .| .||.|| ..|| . ||.|...|.|| .
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1027-1312 2.1e-85 281.6 In-house 13-297 (298) alignment
Range on Protein: 1027-1312
Range on HMM: 13-297/298.0
EFQEHVEKLDKNKQEIFNEIFEFINSTSPDY-ACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETT
 .|. ...  |.|   ... |. .||.| .  .   . | ..... |||| |. |.|..|| |... .  .| |||| |...|.. . .||||.| .||.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

DDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTteKERTVLQFHYTAWPDRNVPAQASHVLDF
 ||||||.|.   |||||||| |. | |.|.|||..|.  ||.| |.. .. |   ...| .|| ... .  |||.| |.|.| |||. ||..|. |||.
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldl

LRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAV
|| ..  . .    |..|.|||||||.|| ||.|  ||..| |..||.  .|  |||.| ..||.  ||.||..|.|| .  ... .
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0040438 (Phosphotyrosine protein) phosphatases II 1028-1339 7.5e-93 306.5 In-house 5-310 (317) alignment
Range on Protein: 1028-1339
Range on HMM: 5-310/317.0
FQEHVEKLDKNKQEIFNEIFEFINSTSPDyacIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDD
. .....|.|.   .. | || . | ..|     | |...  . ||||.|.  .||.|| |. ..|...| ||||....|..  . .||||||...|..|
lllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
||||||||.. .|||||.|.|  . ||.||||. .   |||. |..   .||...|.| ..| .    ....||| .||||.||| .||   ...||||.
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfle

AINSANDkEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQEP
|...|.. .. ||..||||||||||||.||....||||. |..||.. .| .||.|| ..|| . ||.|.. |.|| . ...| . . |.| ...||..|
avreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip

TLINEEFNKIGS
  ... ..|. .
lalddvklkeke

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1028-1332 3.7e-66 218.5 In-house 10-315 (325) alignment
Range on Protein: 1028-1332
Range on HMM: 10-315/325.0
FQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAheyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDD
. |||||   . |. |   |... |  .    .| . .   .. |||...| |.|..|| |.     |.| ||||.... . . . ..|.| |. .|..|
lvehvekkkaqdqdgfahefgllpsddgiakkvamkpe...nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatind

FWRMVWEQRtVTIVMLTNLMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTteKERTVLQFHYTAWPDRNVPAQASHVLDF
.||.| . |  ..|...| ..  | .| .|||        .| . |..    |.  |  | ..| . ..   . |.| ||.. .|.|  |. . . .. .
lWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG..etrsvkqfqlqswddmGvqkrpatlisi

LRAINSANDK-----EEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDR
|. ..  ...     .  .||.|||||||||||. |.|  ||...  | .||| | |  |||.| .||..  |||.|..|. | .. |.| | .  |. .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

CMKLQEPTLINE
   |||   . .
lsslqernpltq

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1029-1305 4.9e-82 270.2 In-house 3-276 (281) alignment
Range on Protein: 1029-1305
Range on HMM: 3-276/281.0
QEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAahEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDF
..|...|..|... | | .| ...   | .  || |  . ...||||... |.|.|||....     .. ||||||..||...| |||||||  .. ..|
rkhlkqlsqndnaGfieeyeklaaigvdntataska..denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSG-QCCYGDIAVRVDRNIELPHYTIRGFKVfnERDTtEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
|.|||||.  .|||.|. .|. | |||.|||    .  |||. |.  .. | ..|  | ||.  ||..  ..|.| |..||||||  |||.....|.| .
WqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eres.getreveqlaytaWPdhGvPattkellefrk

AINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLE-NKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
.......|..  |.|.||||||||||| |||| ...... | ...|.| .|. |||.|. |||.. || |.. |.|. .
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_PTPN9_pd Subfamily PTPN9 1029-1303 2.1e-74 245.3 In-house 7-288 (297) alignment
Range on Protein: 1029-1303
Range on HMM: 7-288/297.0
QEHVEKldKNKQEIFNEIFEFINStSPdyACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDF
 ..|..  |.|. . .| .|  |  ..  .  .  . .  . .|||| ||  .|.|||.|..... ..| ||||||. ||.  | .|||||| ..|..||
vayvke..kgkrGlskeyaeirne.pv..eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFL
|||||||....||| | ..|  . || ||||..   .  .||. |..    |  .|..| ... |   .||..|.|  | ...|||  || .|. .||.|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv..kteesrkvthfqflsWPdyGvPssaaslldvl

RAINSAND------------KEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
... ..              . .  |||||||||.||||| |.|||.|..|. ...||.   |  ||.||  ..|   || | . |.||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1030-1307 6.8e-86 282.9 In-house 10-280 (288) alignment
Range on Protein: 1030-1307
Range on HMM: 10-280/288.0
EHVEKLDKNKQEIFNEIFEFI-NSTSPDYACIASLAAheyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDF
..| | ...... |.| .. . .  . .  ....||    ...|||||.. ..|..|| |.. . .. . ||||..|.|.. .| |||||||  .| .||
akvakksarnrtgfseeynsLaalektksvtagrlav...nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndf

WRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ-CCYGDIAVRVDRNIELPHYTIRGFKVFnerdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
|..|.|..| ||||||.|.|  |.||..|||....   ||.. | .  . || ... | . .      ...|... |..|.|||| .||...  .|..||
WelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellr

AINSANDKEeYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILeDIVY
 .. ||...  |||.|||||||||||| |||| ...... |...|. |.|. |||||...|| | ||.||....| ....
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll.slie

subfamily_PTPN6_pd Subfamily PTPN6 1030-1303 8.5e-77 253.1 In-house 11-295 (306) alignment
Range on Protein: 1030-1303
Range on HMM: 11-295/306.0
EHVEKLDKN----KQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQeIPGVPHSHYINANFIKGY--HDDKLYIATQGPKEE
..|..|.|.    ... |.| || .. .   .    . .|.   ..||||. .  ||||||.|.  |.|| | |||||.||.     || ||||||  |.
qrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclet

TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ-CCYGDIAVRVDRNIELPHYTIRGFKVFNeRDTTEKERTVLQFHYTAWPDRNVPAQASHV
|  |||||||.. .  |||.|. .|  |.|| .|||.. .   ||.| |.  .. .| .|..| ..| . ... ..||.| |.|...||| .||.. ..|
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfksWPdhgvpkdpgav

LDFLRAINSANDKEE---YGPIVVHCSAGVGRTGTIIALDIALEQLK---LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||. .|. ... |    ||||||||||.|||||.| .|| |....   |. ..||. .|  .|.||...||   || |...|| .
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_PTPN23_pd Subfamily PTPN23 1031-1304 5.3e-56 184.6 In-house 5-279 (288) alignment
Range on Protein: 1031-1304
Range on HMM: 5-279/288.0
HVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQeipgVPHSHYINANFIKGYHDD-KLYIATQGPKEETTDDFW
....   . .  ... |. ....    |   |.|. .   .|||.||.  .||.||.|.      .  |||| |.|.       .||||.|...|  |||
elqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS-GQ-CCYGDIAVRVDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
.||.||.. .||||..  |  | |...|||.. |.   .||. | . .. |....  | .|.  ..  ... ..|   ..|.||.  |||  ...|.|| 
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld..adavksvshlqltsWpelGvPasPetllqfld

AINS---ANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKV-DIKGIVTFLRKQRKQMVQALCQYIFIHNAILED
...|   |. ..   |.||||||||||||..  .  |...|. .| . ||  .|  ||.||. |||   |. |  .|.|| 
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0036941 (Phosphotyrosine protein) phosphatases II 1034-1318 7.9e-87 286.6 In-house 6-290 (297) alignment
Range on Protein: 1034-1318
Range on HMM: 6-290/297.0
KLDKNKQEIFNEIFEFINSTSPdyACIASLAAHEYDQTKNRYRDVGAFDHTRVTLqeipGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVW
. ...   .. . || . .  .   .  | |. .  ..||||.|. ..||||| |    . ..| ||||....||. .. .||||||...|..|||||||
lekllflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EQRTVTIVMLTNLMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIE--LPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAI
||.. .|||||.|.|  . ||.||||.   .  .|||. |.. .  .  |..||.| ..| .    ....||| .|||| ||| .||  ....|||....
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielv

NSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLK---LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFK
......  . ||..|||||||||.||.||.|..|.||.    |..|||. .| .||.|| ..|| | ||.|.. |.|| . ...| . .....
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1035-1303 6.7e-59 194.0 In-house 12-291 (301) alignment
Range on Protein: 1035-1303
Range on HMM: 12-291/301.0
LDKNKqeiFNEIFEFINSTSPDYACIaslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPG--VPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMV
  .||   |.| .. ....... . .     .| ... ||....  .|. |..|.. |   . . .||||..|.|| . | .||.||| ..|  ||||..
khsnk...feeqykelkegedksctv...glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrli

WEQRTVTIVMLTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRNIELPHYTIRGFKVF-----N----ERDT----TEKERTVLQFHYTAWPDRNVPA
|....|.|||.||| |. ||||.||||.|   .  .| . | .  .  .| ..|| ..|      |    ||      . . ..|||.. | ||.  |  
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

QASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
.   ||  .  .  .. | . ||.|||||..|.|.|. ....|.||| | |  ||. ...  .|...  .|. | ||..|...| .
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1035-1303 2.1e-46 153.3 In-house 11-275 (307) alignment
Range on Protein: 1035-1303
Range on HMM: 11-275/307.0
LDKNKQEIFNEiFEFINSTSPDYACIaslAAHEYDQTKNRYRDVGAFDHTRVTLQeIPGVpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWE
|||  |.. .| |. .   .|.   .    | . .. ||||.|| . |..|. .. ..|.  | || ||..    . | .|..|||.|.|  .|| |. .
ldkgvqalvde.frvlakktpegvtv...eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

QRTVTIVMLTNLMESYKSKCHQYWPSS-GQ-CCYGDIAVRVDR-NIELPHYTI--RGFKVFN-ERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRA
..  ...|| ...|  | ||.||||   ||   .|. .  .   |.   . .      .| . . | ..| ||. .. .. |||| ||      ...| |
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

INSANDkeeygPIVVHCSAGVGRTGTIIALDIALEQ-LKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
..  ..     |.||||||||||.|||.|. .  .. .. .|  |.| .|  ||.||.  .|.  ||...|  .||
vrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1035-1303 9.7e-43 140.9 In-house 19-287 (305) alignment
Range on Protein: 1035-1303
Range on HMM: 19-287/305.0
LDKNKQEIFNEIFEFINSTSPDYACIASLA--AHEYDQTKNRYRDVGAFDHTRVTLQEIPgvpHSHYINANFIKG-YHDDKLYIATQGPKEETTDDFWRM
||   . . .|. .. . | || . .|  |  . . ..|||||.|| . |.. | |.. .    |.|| ||..      .| .|..||| ..| |.|| |
ldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwm

VWEQRTVTIVMLTNLMESYKSKCHQYWPSSG-QC--CYGDIA-VRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
| ...   |||| . .|  | || |||| .  .     . |    |  .  .   .     ..|   . ... .| ....| |||| ||      |..| 
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslells

AINSANdkeeyGPIVVHCSAGVGRTGTIIALDIALEQLKlENK--VDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||  ..      |||||||||.||||||.|..  ||..  |||    .  .|  || ||   .|.  ||.|||  .|.
airgsk.....vpivvhcsagigrtgtivaieyilekia.enkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1036-1313 1.7e-60 199.3 In-house 4-274 (283) alignment
Range on Protein: 1036-1313
Range on HMM: 4-274/283.0
DKNKQEIFNEIFEFINStsPDYAciASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGvphsHYINANFIK---GYHDDKLYIATQGPKEETTDDFWRMV
 .|....| | .. ..   ||    | .|. . ...|||.... . |  || |.  .     .|||| ||     |..|| ||..|.| ..|  |||.||
rvnnnklfrevlkrlsv..pdld..adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTtEKERTVLQFHYTAWPDRNVPAQASHVLDFlRAINSA
.... ..|||||.|.|  . || ||||. |   ||. .| . ..     ..|. . . ..  . ...  .  . .  | . .  |    .. |   . | 
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssa.kstlllahyqvidWleygeqaiinslvkf.nkvisl

NDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVT
  ... ||||||||.|.|||.. ||.  ...... |  ||.  .|. .|.||  .||.| || ..|...||. . ||| ..
qteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1036-1296 2e-31 103.9 In-house 18-272 (301) alignment
Range on Protein: 1036-1296
Range on HMM: 18-272/301.0
DKNKQEIFNEIFEFINSTSPDYACIASLAAHeYDQTKNRYRDVGAFDHTRVTL-QEIPGVPhshyINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWE
|..  ...|  .| .| |. |   |    |.   . |.||  |    .| | . ..   ||    | ||.|.   . . .|||||| ..|..||| |.  
ddktakfynttienvnvttidkdhitesyay.lpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvq

QRTVTIVMLTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRN--IELPHYTIRGFKVfneRDTTEK--ERTVLQFHYTAWPDRNVPAQASHVLDFLRA
    .||||.. .|  ..||..| |..   .   |   ...  .  |   . . | ..|   .|.|.|   |||. . |. |.||.||    .. |..  
ydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlev...edstgkfatrtvthyqysewtdrgvPkshaelfdlmel

InsandKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIF
.     |.   |||||||||.||. . |. ..   ... .......  .  ||..| . ||   |  .
v.....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

0047943 (Phosphotyrosine protein) phosphatases II 1037-1303 7.9e-87 286.5 In-house 8-270 (273) alignment
Range on Protein: 1037-1303
Range on HMM: 8-270/273.0
KNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLqeipGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQR
..   .. | || . |. |.. .  | |...  ..||||.|. ..||.|| |    | ..|.||||....||.  . .||||||...|..|||||||||.
llgltllleefelllslkpllty..svallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

TVTIVMLTNLMESYKSKCHQYWPSSG---QCCYGDIAVRVDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSAN
. .|||||.|.|  . ||.||||..|      ||.. |.. .  . ..||.| ... |    |...||| .|||| ||| .||.. ...|.|......|.
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrkal

DKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
 .  . ||.|||||||||||||.||||..|.||. |..||.. .| .||.||  ||| ..||.|...|.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1037-1303 2.8e-48 159.0 In-house 24-281 (290) alignment
Range on Protein: 1037-1303
Range on HMM: 24-281/290.0
KNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEipGVPhSHYINANFIKGYHddKLYIATQGPKEETTDDFWRMVWEQR
|| .|.  | .| .    |      ..  .. . .||||.||   | ||| |..  | .   |. ||..|| .    .| |||. ..|. |.|||| ...
knvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gyd.GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqek

TVTIVMLTNLMESYKSKCHQYWPS-SGQC-CYGDIAVRVDRNIELPHYTIRGFKVFNERDtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANd
. .|||| .|.|  |.||.||.|  .|.   .|.|.|    . .    .|.      ..| . ||  .  ..  .|||. |.  .  .|  ||..  |. 
vaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkd.sGkehklkhlkikswpdksvalstlallrtlrilrkas.

keeyGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
    ||.|||||||.|||||..|....|. |    ..|. ..|  ||. | . ||   ||. . ...|.
....GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_PTPN1_pd Subfamily PTPN1 1038-1312 1.8e-63 209.0 In-house 3-280 (290) alignment
Range on Protein: 1038-1312
Range on HMM: 3-280/290.0
NKQEIFNEIFEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGvphsHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRT
.|.. ..||.. |.  . |. . .  | .. ....||||||  .||.|..|..       .||||....  . .. || ||||  .|.| ||.|||||..
dkkrlykeiyldirkeasdfptre..aklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqks

VTIVMLTNLMESYKSKCHQYWPSSGQ---CCYGDIAVRVD--RNIELPHYTIRGFKVFNerDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAI-NS
 ..||| ...|  . ||.||||.  .     . |. ..|.  .. .  .||.| ... |   .|.. |..|.||||.|||  ||   .  |.||  . .|
kavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen..lktqetreilhfhyttwpdfgvpespaaflkflfkvres

ANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENK---VDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI--VYGDTAV
   ....|| |.|||||.||.||.. .|  | ... ...   ||||  .  |||.|  ..|.  |  | . |||| .  . ||..|
GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv

subfamily_eak_pd Subfamily eak 1038-1219 2.4e-12 40.9 In-house 17-198 (332) alignment
Range on Protein: 1038-1219
Range on HMM: 17-198/332.0
NKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDV-G--AFDHTRVTLQEIPgVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWE
||. |.| | . ||  .        |. .| .....  |.| .   .|.  | |       .  ||||  ..  .  . || |  ..|.    ||.|| |
nknhiwnrinqrinivadlddyqrllsisetarleavnrnvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvle

QRTVTIVMLTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTtekeRTVLQFHYTAWPDRNVPAQA
|.. .||.| . .|    |  .|.|  .  .  .| . |     ..   .  | ...    .|      || ...  | . ..|   
qkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet....hrvlhykvfGwtettlpkye

subfamily_CG7180_pd Subfamily CG7180 1041-1307 1.4e-62 206.1 In-house 17-292 (296) alignment
Range on Protein: 1041-1307
Range on HMM: 17-292/296.0
EIFNEIFEFINStSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTI
  .. ... ..       | . | ..   . |||. .|  .|..|| |... |  .|.|||| .. ..  .| || |..||.|| |.|||.|... . ..
veyklelkltpr.leigdCagglrke..nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VMLTNLMESYKsKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNE--------RDTTEKERTVLQFHYTAWPD-RNVPAQASHVLDFLRAINS
|.||. ..  | ....|||  ..  ||.| | . .. .... .|| ||.  .        .. . ..|.|..|..| |.   .||  .. .....| ...
vvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

ANDKE----EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVY
  .|     |.||.||..| |..|.|  .|.|..||... |..||. . |  ||..|.|.|.   .| .| . .|| .. 
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1041-1303 5.6e-41 135.3 In-house 6-257 (267) alignment
Range on Protein: 1041-1303
Range on HMM: 6-257/267.0
EIFNEIFEFINSTSPDYACIASLAAHEyDQTKNRYRDVGAFDHTRVTLQEIPGVphshYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTI
  ... || |.  |.. . |.   |..  | .||. |.  .|.||| |..        |||| ...||.  . .|.||.| . |  ||. .. .|.  .|
ceiekefelikkisdtsstisqsiaek.nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLtnlMESYKSKCHQYWPSS-GQC-CYGDIAVRVDRNIELPHYTIRGFKVfneRDTTEKERTVLQFHYTAWpdrNVPAQASHVLDFLRAINSANDKEEY
|.|   . ... . ...||   ||.  | |..|    . |   | |  ...   .   |  . |  ..|  |   |. ..    |  | .| . |. |. 
vll...tkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtlyyykkw...nintnnkpylkplfgilaknqleng

G-PIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
. |.||.||.||||.|| . .|  ||..| |. .||   .  .|.||  .|... .||.||. . |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1042-1325 5.9e-59 194.4 In-house 21-256 (392) alignment
Range on Protein: 1042-1325
Range on HMM: 21-256/392.0
IFNEifEFINSTSPDYACiASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIV
.| |  || .  .||     . | .| .. ||||...  .| .|| |. |  .|.| |.|| .|.... .| |||.|||.  . |||||||..... ||.
lffe..efhdlpgpdiyp.qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

MLTNLMESYkskchqywpssgqccygdiavrvdrnielphytirgfkvfnerdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSanDKEEYG-P
|.|.| |                                                .. ||| |||.| |||..|| ..| .| |.. ...  |  .|  |
mvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka..dfGqythp

IVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQ
...|||||||||| .|..|  . . |    ||.  .|| .|..|  |||.  || ||. |.|||... .| . .  | |.  .|.
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

subfamily_PTPN12_pd Subfamily PTPN12 1043-1303 5.1e-78 256.9 In-house 14-275 (290) alignment
Range on Protein: 1043-1303
Range on HMM: 14-275/290.0
FNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVM
|... .  .    . .. .. . .|....||||.|.  .|..||.|..| ....| ||||||||| .... |||.|||  .| ||||||.||...  .||
fqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvm

LTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRNIELP-HYTIRGFKVFNErdttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDkEEYG
. ...|  | ||..|||..|  .. .|.. | ....  .   ..|| .|| ..    ...|.| |||||||||..||..|...|........ .. .|  
aCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.seda

PIVVHCSAGVGRTGTIIALDIALEQLKLEN---KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|.||||||||||||||||.|.. |.|| |.   ..|.  .|. |||||. .||.  || ....|..|
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1043-1109 1.6e-10 34.9 In-house 24-87 (440) alignment
Range on Protein: 1043-1109
Range on HMM: 24-87/440.0
FNEIFEFINSTSPDYACIASLAaheYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYH
|.. . .. |   . . ||||     .. |||||.. |.||.|| |.|. |||.|.|||| .|.| .
fedewsllpsglsqpsdiaslp...nnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1043-1224 6.9e-08 25.6 In-house 5-163 (169) alignment
Range on Protein: 1043-1224
Range on HMM: 5-163/169.0
FNEIFEFINSTspDYA-CIASLAAheyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINAnfikgyhddklyiatqgpkeettddfwRMVWEQRTVTIV
.||. ||..    .|   .| |..   ..||||     |  |||| || .     | ||||                           ||.||  .  ||
ynelkefmkti..eynnfmaeltc...netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasviv

MLTNLMES--YK--SKCHQYWPSS--GQCCYGDIAVRVDRNIELPHYTIRGFK---VFNERDTTEKERtVLQFHYTAWPDRNVPAQASHVLD
.| .  .   .    . .|  |.   |.     . || |.   . .     |.   |. . | .  |. .  .||..||.  ||    ||  
vlgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvtek.lsllhystwpqngvpqspvhvgh

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1043-1223 5.1e-07 22.7 In-house 4-161 (169) alignment
Range on Protein: 1043-1223
Range on HMM: 4-161/169.0
FNEIFEFINSTspDYA-CIASLAaheYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINAnfikgyhddklyiatqgpkeettddfwRMVWEQRTVTIV
.||. ||..    .|   .| |.    ..||||     |  |||| || .     | ||||                           ||.||  .  ||
ynelkefmkti..eynnfmaelt...cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasviv

MLTNLMES--YK--SKCHQYWPSS--GQCCYGDIAVRVDRNIELpHYTIRG-FKVFNERDTTEKERTV--LQFHYTAWPDRNVPAQASHVL
.| .  .   .    . .|  |.   |.     . || |.        . | |.|    .  ... |.    .||..||.  ||    || 
vlGdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpn.tsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvg

subfamily_PTPN13_pd Subfamily PTPN13 1044-1303 6.3e-66 217.4 In-house 14-267 (273) alignment
Range on Protein: 1044-1303
Range on HMM: 14-267/273.0
NEIFEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGvphshYINANFIKGYHDD--KLYIATQGPKEETTDDFWRMVWEQRTVTIV
.| |. ..   |   |    . .. ...|||||.|  .|.|||.|..  |     ||||..||   ..    |||.|||  ||..|||.|||||..  |.
aeefkelrelkpldtcev..gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLTNLMESYKSKCHQYWPSSGQ---CCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDkeEY
|.|.  |. | |||.|||.| .     .. . |.. .  .|  ...| ..| .    ... | | ......||| .||..| ..| |.. ... ..  . 
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds..esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..da

GPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||||||||.||.||.|..|..|. .. ....|.| ||  ||.||. .||.  ||||...||||
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

0046845 (Phosphotyrosine protein) phosphatases II 1046-1308 9.9e-91 299.3 In-house 5-277 (284) alignment
Range on Protein: 1046-1308
Range on HMM: 5-277/284.0
IFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGV-PHSHYINANFIKGY-----HDDKLYIATQGPKEETTDDFWRMVWEQRTVT
 || ..|  ... .  | |...  ..||||.|. ..||.|| |. ..|  ..|.||||....||     .  | .||||||...|..|||||||||.. .
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLTNLMESYKSKCHQYWPSSG-QCCYGDIAVRVDRNIELPHYTIRGFKVFNErDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDK-EE
|||||.|.|  . ||.||||..|    |||. |.. .  . ..||.| ... |. ..|...||| .||||.|||..||......|.|||........ . 
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

YGPIVVHCSAGVGRTGTIIALDIALEQLKLEN---KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYG
 ||||||||||||||||.||||..||||. |.   .||. ..| .||.|| .||| | ||.|...|.|| . ..
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1046-1302 1e-56 186.9 In-house 15-274 (287) alignment
Range on Protein: 1046-1302
Range on HMM: 15-274/287.0
IFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
 .. .   |   . .   | . ..  |||| ||  .|.||| | . .    | |||||.. .|.||. .||.|||   |  ||||.|.|.|. .....| 
evdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

LMESYKSKCHQYWPSSGQCC--YGDIAVRVDRNIELPHYTIRGFKVFNeRDTtEKERTVLQFHYTAWPDRNVPAQ----ASHVLDFLRAINSANDKEEYG
 .|  . ||..|||   .     |   | .|..|  |.|..| ... .  .| .. | | |... .|||. ..      .  |||  . |. | | .| |
eveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid.let.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
|.|||...|.||.|...|. . ...|.   .||.  .| .||..|. .|||  |. .. .|. 
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

DSPc_SM00195 1047-1303 1.6e-85 282.0 In-house 6-260 (263) alignment
Range on Protein: 1047-1303
Range on HMM: 6-260/263.0
FEFINSTSPDYaciA-SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
|| ...  ..      . |...  ..||||...  .||||| |..... ..| |||||.|||.. .| |||||||...| .||||||||... .|||||.
fekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELP-HYTIRGFKVFNERDttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeYGPIV
 .|. | ||..|||..  |.  .|.| | . .... . ....| ... .| .  |..|.| |..|..|||..|| ....||..|||... ....  ||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||||||||||....||.|..|. |.||||. ||. ||||| .||| | ||.||..||||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 1047-1303 1.6e-85 282.0 In-house 6-260 (263) alignment
Range on Protein: 1047-1303
Range on HMM: 6-260/263.0
FEFINSTSPDYaciA-SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
|| ...  ..      . |...  ..||||...  .||||| |..... ..| |||||.|||.. .| |||||||...| .||||||||... .|||||.
fekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELP-HYTIRGFKVFNERDttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeYGPIV
 .|. | ||..|||..  |.  .|.| | . .... . ....| ... .| .  |..|.| |..|..|||..|| ....||..|||... ....  ||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||||||||||....||.|..|. |.||||. ||. ||||| .||| | ||.||..||||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

subfamily_PTPN3_pd Subfamily PTPN3 1047-1303 7.8e-72 236.5 In-house 21-273 (280) alignment
Range on Protein: 1047-1303
Range on HMM: 21-273/280.0
FEFINSTSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQEIPgvphSHYINANFIKG----YHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVM
|| .    |. |. |.  ..  . .||||||. ..|.|||.|.| .    . |||||...      .  . ||||||| ..|. |||.|||||.. .|||
feqlyrkkpglaisaarkpe..nlsknryrdilpydatrvklkese....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTNLMESYKSKCHQYWPSSG-QCCYGDIAVRVDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPI
||.|.|. . |||||||... .. ||.. |.. .. |   | .| . . ...  |..||..||. |.|||| .|| .....|.|.. ....   .|  |.
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke.ePv

VVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|||||||.|||| .|.|..||  .  ...| .  ||  .| ||. .||.  || |. .|||.
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1047-1303 2e-45 149.6 In-house 17-267 (281) alignment
Range on Protein: 1047-1303
Range on HMM: 17-267/281.0
FEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQE-IPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
|  .    |   | .    .  .. |||| .. ..| .|| |.  .|    . || ||.|.     . || |||||.||  |||||.|.. | .|||| .
fsnlpgdppsdlctv..fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

LMESYKSKCHQYWPSSGQCCYGDIAVRVDRN---IELPHYTIRgFKVFNErdttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANdkeeyGPIV
..|. . || .|.|   .||     . |. .   ..    | | ...  |     . | . .. .  ||| .||  .  .|  || | .        | |
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.lnlsye....getrlithwlwkewpdwqvpessevmlkilrkirars.....tppv

VHCSAGVGRTGTIIALDIALEQLKLENK-VDIKGIVTFLRK-QRKQMVQALCQYIFIHNAILE
.||||||||.||..|..|||. ..      ||| ||. ||   |   ||.| ||..| . .|.
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1048-1324 2.9e-72 238.2 In-house 24-296 (315) alignment
Range on Protein: 1048-1324
Range on HMM: 24-296/315.0
EFINSTSPDYACiASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLM
|| .   ||       | .. ...||||...  .|..|| |. |   |.| |||| .||...||| |||.|||.. . |||||||..... ||||.|.. 
efhdlpdPdiyr.qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkq

ESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIELPHYTIRGFkvfNERDtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYgPIVVHC
|. | || ||||   .    .| | | .         ..| .     |. .|. ||| ||..| |||. |. |.| .| ..... . |.|.|. ...|||
egdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrk.seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef.sllvhc

SAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKL
|||||||| .|..|  ..|.| .. ||.  .|. ||..| ..||.  .| ||..|.|||. . .| ...  | |.   |
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdl

subfamily_egg_pd Subfamily egg 1049-1308 4.6e-32 105.9 In-house 22-276 (307) alignment
Range on Protein: 1049-1308
Range on HMM: 22-276/307.0
FINSTSPDYAcIAsLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLME
 .. .. . . .   || .  ..| | . |   | .||.|.   |     .| || .||      .| .| |  .| |||||||....   |||||   |
vleesvdeis.lt.taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrke

SykSKCHQYWPSSGQC--C--YGDIA---VRVDRNIElPHYTIRGFKVFNERdttEKERTVLqfHYTaWpDRNVPAQASHVLDFLRAINSANDkeeygPI
|   .|. ||| . .       | .    ..||.. . | ...  .|.       ..|| .   |.  . | |  ..    |  || .  .       |.
s..erceyywpkaesdslvtvpGslrienlkvdskad.plfrvtklklvGgd...deerfle..hwq.g.dvnnssdvysplrvlrklrnlsk.....pv

VVHCSAGVGRTGTIIALDIALEQLKL--ENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL---EDIVYG
||..  || ...|..|..||| .|      |  ..  | |||..|.  |..  .|.|..  .|    |..  
vvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1053-1307 2.7e-36 120.1 In-house 27-273 (288) alignment
Range on Protein: 1053-1307
Range on HMM: 27-273/288.0
TSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQeipgVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKS
 ||. | | .  ..  . |..||...   | ||| |.         ||.|| .   . ..  | .| | . | . .|.|. |.    ||||..|.|  | 
dspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

KCHQYWPSS-GQC-CYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKErTVLQFHYTAWPDRNVPAQASHVLDFLRAInsandKEEYGPIVVHCSAGVG
|  .|.||  |.   .| .   | .. .  . ...   . ... . ||   | . |.  |.|  || .    | .|  .     |.   |||||.|||||
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvG

RTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVY
||||.|   ||||.|.|.. . |. ... ||..|.. .|.  ||...|  .||....
rtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1054-1309 3.4e-30 99.8 In-house 32-279 (312) alignment
Range on Protein: 1054-1309
Range on HMM: 32-279/312.0
SPDYACIASLAAHEydqtKNRYRDVGAFDHTRVTLQeipGvPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSK
 .|  | | |  ..     ||| ..  .|  | ||    |     || |||.|     . ...|||| |.|.  ||...    ...|..|. ..|    |
vsdsectaflkfkd....lnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsek

CHQYWPS-SGQCCYGDIAVRVDRNI--EL-----PHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINsaNDKEeygPIVVHC
| .|     |     |  |  .     |.      . | | .||     .| .|  . .. ...|||  .|      | .| |..  .||    |.. ||
cakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvk..atgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkk...pviahc

SAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEdIVYGD
|||||||||.. ..  .  |.   | ..| .  .|||.| . |... ||..   ..|| ..|  
sagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle.flysk

subfamily_PTPRN_pd Subfamily PTPRN 1059-1305 4.3e-57 188.1 In-house 46-292 (297) alignment
Range on Protein: 1059-1305
Range on HMM: 46-292/297.0
CIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQY
. ...| .|   .|||...| ..||.||.|.|     .|.|||| .|         |||||||  .|  |||.||||| .| ||.||.| |.  ..|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPSSGQCCYGDIAVR-VDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKeEYGPIVVHCSAGVGRTGTII
||  |.  |.   |. |   |    | .| | . | .  |.. ||| |||. .||...|||.|  .|.| | .| .       |||||||.|.||||. |
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlq..tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

ALDIALEQLK-LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
..|. |..|.   ...||   .  || ||...|..  |. |.  |. |..
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1061-1324 2.2e-72 238.8 In-house 35-295 (515) alignment
Range on Protein: 1061-1324
Range on HMM: 35-295/515.0
ASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS
 ..|  | . .||||...  .| .|| |. |   ||| |.|| .|.... || |||.|||.. ..|||||.|..... ||.|.|.| |. |.|| .||| 
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

--SGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDttekERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPIVVHCSAGVGRTGTIIAL
  .    .| | | .         ..| ..|  . |     ||| |||.| |||. || ..| .| ..... . ... .  |...|||||||||| .|..
kpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisi

DIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKL
|  . . |  . ||.  .|| .|..| ..||.  || ||..|.|||. . .| . .  | |    |
dsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

subfamily_PTPRK_pd Subfamily PTPRK 1062-1322 3.5e-82 270.7 In-house 36-294 (314) alignment
Range on Protein: 1062-1322
Range on HMM: 36-294/314.0
SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS
  | .. ...|||. |. |.|..||.|. | | |.| ||||..| .|.  . .|.||||..||. ||||.|..... .|||||.|.|  . || .|||  
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GQCcYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKeEYGPIVVHCSAGVGRTGTIIALDIA
..  |||| | . .   |  . .| |.| .   . |. |.| ||....||| .|| .|  .|...| ... ... | |.|||||||| ||||| ||.|| 
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

LEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCM
|. .. |. ||.  .|  ||...  ||..  ||.||...|||  . |.||. . |||   .
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl

subfamily_ptpA1_pd Subfamily ptpA1 1062-1265 2.3e-36 120.5 In-house 40-256 (418) alignment
Range on Protein: 1062-1265
Range on HMM: 40-256/418.0
SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHdDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS
|   .... .|||| ..   .|||| |..|     | |||||.| | .  | .|.||||  .|  ||||||||.|   ||||.   |  . || .|||  
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

-----------GQCCYGDIAVRVDRNIELPHytiRGFKVFNERDTTEKE-RTVLQFHYTAWPDRNVPAQASHVLDFLRAINSAND-----KEEYGPIVVH
           |.  .|  .| .   |. |    |     | | | | | | . |..|  |||.|.| ..  . ..|..|   ..      .   ||.||
iggeqfsiygngnevfgtysvelveviqdpe...reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGVGRTGTIIALDIALEQL
||||||||||. .  | ...|
csagvgrtgtfctavimmkkl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1063-1318 1.6e-76 252.7 In-house 55-304 (319) alignment
Range on Protein: 1063-1318
Range on HMM: 55-304/319.0
LAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTnlmesyKSKCHQYWPSSG
 |  . .. |||. .. |||...| |. . |.  | |||| |..||   . |||.|||...| .|||||.||... |||.||      | || ||||  .
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki

QCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIA
.  ..   |.||   |   |..| ... ..   .   | . |||.  |||  || ..| .. ... ..  ..||.   .|||||||||||||. |.||. 
vikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFK
|...| |..||.  .|  ||.||...|| | || ||. |.||. ..| . |.. .| 
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfp

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1063-1306 3e-33 110.0 In-house 29-271 (285) alignment
Range on Protein: 1063-1306
Range on HMM: 29-271/285.0
LAAHEYDQTKNRYRDVGAFDHTRVTLQEIpgvpHSHYINANFIKGY-HDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS
 .|.| .   ||| || . . ||| |..        || |....   .|.  ||.||||  ||  |||.|.....   ..||  |.|    ||  |.|  
ytayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

-GQ-CCYGDIAVRVD--RNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEygPIVVHCSAGVGRTGTIIA
 |.   .|   . .   ..  .    .  . | |  |.. .   . . .   |||.  | .|  .... . ..  | ||.  ||.|||||||||| |.. 
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek..picvhcsagvgrtatfvg

LDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
.| |  ..  . ....  ||  .|  | | ||.  |..|..  ..| ..
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1064-1306 6e-81 266.3 In-house 4-243 (250) alignment
Range on Protein: 1064-1306
Range on HMM: 4-243/250.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSkCHQYWPSSGQ
| .  .. |||| |. |.|..|| |..  |  .| |||| |..||.. |..|||||| ..|. ||||||.|. . |||||||| || |  .|||||  . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

CCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALE
  |||. | .  . |   ||.| .|. ..  . ..||.| |.|...|||. ||..|  ||..|. ... ... . .|..|.|||||||.|. ||.|  ||
ekyGdvtvsllskeefadytkrklklska..kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
.|| |..||.  ..  |||.| ..|..| ||.|....||. ..
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

0042113 (Phosphotyrosine protein) phosphatases II 1064-1303 3.1e-80 264.4 In-house 4-241 (245) alignment
Range on Protein: 1064-1303
Range on HMM: 4-241/245.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ
|... ...||||.|. ..||||| |....| ..| ||||....||.  . .|||||| .||..|||||.||..  ||||||...|  . ||.||||... 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

CCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALE
  |||. |.. .   |..||.| ..| |.   . ..|.|...||. ||| .||   ...||||.....|  . . ||..||||||||||||.||....||
ltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||. | .|..  .| .||.|| ..|| . ||.|.. |.||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 1064-1303 6.9e-74 243.7 In-house 5-240 (243) alignment
Range on Protein: 1064-1303
Range on HMM: 5-240/243.0
AAHEYDQTKNRYRDVGAFDHTRVTLqeipgvPHSHYINANFIKGYhdDKlYIATQGPKEETTDD----FWRMVWEQRTVTIVMLTNLMESYKSKCHQYWP
| ......||||.|. ..||.|| |      . | |||||.|...  .. .|||||| .||..|    ||||.||... .|||||.|.|  . ||.||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

ssGQCCYGDIAVRVDRNIELPHYTIRGFKVFNeRDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDK-------EEYGPIVVHCSAGVGRT
  |. .|||. |..    .|..||.| ... |  |... .|.| ..||..||| .||   ...||||.....  ..        . ||..||||||||||
..gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTIIALDIALEQLklenKVDIKGIVTFLRKQRKQ-MVQALCQYIFIHNAILE
||.||... |..|    .||.  .| .||.|| . .|| . ||.|.. |.||
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1064-1317 3e-64 212.0 In-house 46-296 (297) alignment
Range on Protein: 1064-1317
Range on HMM: 46-296/297.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDdkLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKsKCHQYWPSSGQ
| .  .  |.||...  .|  ||.|. .   | | |.|| |.||..    .|.|| |...| .|||.||..... |||||... |. | || .||. .| 
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

CCYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYTAWPDRNVPA--QASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIA
  .||..| .    |   .  | ..|  ... . ..| | |.... |||..|.   .|| .|...  ..   .... ||..|||.||||||| ....|  
ttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

LEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEF
. . | |..||| |.|. ||..| ..||.  || |...|.|| ..  ||.. .. |
vaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf

0049772 (Phosphotyrosine protein) phosphatases II 1064-1303 8.7e-46 152.4 In-house 41-278 (314) alignment
Range on Protein: 1064-1303
Range on HMM: 41-278/314.0
AAHEYDQTKNRYRDVGAFDhTRVTLqEIPGVPHSHYINANFIKGYhddKLYIATQGPKEETTDDF----------WRMV--WEQRTVTIVM---------
| ..  ..|||| |.  .| .|| |    .|  | ||||....|.   . .||||||.|.| .||          ||||  ..... .|||         
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTNLMESYkskchqywpssgqccygdiavrvdrnielPHYTIRGFKVFNERD--TTEKERTVLQFHYTAWPDRNVPaQASHVLDFLRA
            |..|.. .                             ...| . .. ..|.       ||........ .|| ..|   .....||..
lsrLdaAlgKtpllildgng.............................neptaadlellkeelydpelferlgikylripvpDgsap.lledfdeflef

INSAndkEEYGPIVVHCSAGVGRTGTIIALDIALEQLklenKVDIKGIVTFLRKQRK-----QMVQALCQYIFIHNAILE
|..|   .. ||..|||.||.||||| ..... . .|    .|... .. ..|..|       ... |.||.||..|.||
ieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1064-1212 9.1e-11 35.8 In-house 91-232 (244) alignment
Range on Protein: 1064-1212
Range on HMM: 91-232/244.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEipGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESykskcHQYWPSSGQ
|    .  |||      ||  || | .  |     |||| |.        || || |  .|. |||.|. |.    .|.|  . |       .||| |  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep

CCY--GDIAVRVDRNIELphYTIRGFKVFNERDTTEKERTVLQFHYTAWPD
  .   ||.| .    |.    |.  ..  | |  |  ...  |  . || 
lewyeeditvtltdrdef..knikasnleiesdmneshqaltmfqisnwps

0040439 (Phosphotyrosine protein) phosphatases II 1065-1303 3.1e-80 264.6 In-house 7-244 (249) alignment
Range on Protein: 1065-1303
Range on HMM: 7-244/249.0
AHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC
 .. .. ||||.|. ..||.|| |. .||...| ||||..|.||.  . .|||||| .||..|||||.||..  .|||||.|.|  . ||.||||..|  
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

CYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALE
 |||. |.. . .....||.| ... |    . ..||||...|| ||| .||   ...|||..|...|...  . ||..||||||||||||.||....||
eygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

QLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||. |..||.. .| .||.|| ..|| . ||.|...|.||
qlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1065-1327 8e-78 256.5 In-house 45-301 (315) alignment
Range on Protein: 1065-1327
Range on HMM: 45-301/315.0
AHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSgQC
 .  .. |||| .. |.|..|| |  .   |||.|.|||||.||   . |||.|||. .. .||||.|.|.   .|||||||.|  |.|. .|||   . 
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kv

CYGDIAVRVDRNIELPHYTIRGFKVFNerdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPIVVHCSAGVGRTGTIIALDIALEQ
 || |.|    .    .||.| . |       .. |.|.|.|||.||| .||. .  .... | ..  ....  |.|||||||||||||| |.||  |.|
iyGkitvtrkseevnteytvrtlsvvf....gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

LKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQEP
.. || .|.  ..| .|..|..|||.. || ||..|.|| .| |||... | . .|   |  |
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllap

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1065-1303 2.8e-66 218.3 In-house 16-262 (270) alignment
Range on Protein: 1065-1303
Range on HMM: 16-262/270.0
AHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSG-
..  ... |||.|.    .|||.|.|.   ... |||||...|... .| |||..||.. |. .||||.||... .|||.|.|.|  ..|| .|||..  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

---QCCYGDIAVRVDRNIELPHYTIRGFKVFnerDTTEKERTVlQFHYTAWPDRNVPAQAS------HVLDFLRAINSANDKEEY-GPIVVHCSAGVGRT
   .. .|.|.|..  .     | ..  ..    .. |..| |  |.|..|||. || ..       ..|  |||.   ... .  .|..||||||||||
ekvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||.||||||.. |. ..|||.  |.. |||.| ..||   || |...|..|
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1065-1302 4.5e-39 128.8 In-house 48-287 (310) alignment
Range on Protein: 1065-1302
Range on HMM: 48-287/310.0
AHEYDQTKNRYRDVGAFDHTRVTLQeIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC
|..    |||| ||   | .|| |. |    .  || ||..|  .  . .| .||| . |  |||||....|. .|..| . .|  . ||  |||| |  
aykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

-CYGDIAVRV----DRNIELPHYTIR---GFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFlRAINsandKEEYGPIVVHCSAGVGRTGTII
  || | |        ..|.   ..         .|. .  ||  |   ..  |||| || .  | .   | .     .  .|| |||||||..|.....
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rlla....qvrhgpcvvhcsagkdrlyvvv

ALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
||......|.  .|||.. ..| |.|.| . .|.  ||..|.   .
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1065-1143 1.3e-08 28.7 In-house 33-116 (347) alignment
Range on Protein: 1065-1143
Range on HMM: 33-116/347.0
AHEYDQTKNRYRDVGAFDHTRVTLQ-----EIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVML
  | . .||| .||   | ||| |        .  .   ||||  ||    .| || || |  .|  |||.||   .   .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

0045098 (Phosphotyrosine protein) phosphatases II 1066-1303 7.7e-78 257.0 In-house 30-270 (278) alignment
Range on Protein: 1066-1303
Range on HMM: 30-270/278.0
HEYDQTKNRYRDVGAFDHTRVTlqeipgvphsHYINANFIKGYhdDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCC
 . .. ||||.|. ..||.||            ||||..|.||  .| .||||||...|..|||||.||... .|||||.|.|  . ||.||||..|   
ylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

YGDIAVRVDRNIELPHYTIRGFKVFNE--RDTTEKERTVLQFHYTAWPDRNVPAQA--SHVLDFLRAINSAND------------KEEYGPIVVHCSAGV
|||. |..    .|..||.| ..| |   .... ..|.| ..||. ||| .|| .   ...|..|. |..|..             .. ||..|||||||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

GRTGTIIALDIALEQLklENKVDIKGIVTFLRKQRKQ-MVQALCQYIFIHNAILE
|||||..|... ||.|  |..||.  .|..||.|| . .|| | ||.|.. ..||
gRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1068-1319 8.6e-76 250.1 In-house 24-269 (284) alignment
Range on Protein: 1068-1319
Range on HMM: 24-269/284.0
YDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTnlmesyKSKCHQYWPSSGQCCYG
 .. |||. .. |||...| |. . |.  | |||| ||.||   . |||||||...| .|||||.||... |||.||      | || ||||  ..  ..
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

DIAVRVDRNIELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIALEQLK
   |.||   |   |..| ... ..   . . |.. |||.  |||  || ..|... ... ..  ..||.   .|||||||||||||. |.||. |...|
rfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKD
 |..||.  .|  ||.||...|| |.|| ||. |.||. ..| . |.. .|  
eekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpa

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1068-1303 5.8e-63 207.2 In-house 6-238 (239) alignment
Range on Protein: 1068-1303
Range on HMM: 6-238/239.0
YDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGqCCY
 ...|||| .. ..||.|| |...   ||| ||||.... |    | ||||||  | .. |||||.|..| . ||||| |.| .| ||||||| |    |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sky

GDIAVRVDRNIELPHYTIRGFKVfNERDTTEkERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSaNDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLK
 .. | . .   .  | || | . ..   || || | |.|.| |||. ||  |. || . | |   .      | |.||||||||||... .|  | | |
cnlrvtlrktevfadyiirtfvm.sqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
 .. |||   |  .|..| .|||.  ||.||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1068-1303 8.6e-63 206.7 In-house 7-239 (239) alignment
Range on Protein: 1068-1303
Range on HMM: 7-239/239.0
YDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGqCCY
 ...|||| .. ..||.|| |...   ||| ||||.... |    | ||||||  | .. |||||.|..| . ||||| |.| .| ||||||| |    |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sky

GDIAVRVDRNIELPHYTIRGFKVfNERDTTEkERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSaNDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLK
 .. | . .   .  | || | . ..   || || | |.|.| |||. ||  |. || . | |   .      | |.||||||||||... .|  | | |
cnlrvtlrktevfadyiirtfvm.sqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
 .. |||   |  .|..| .|||.  ||.||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1068-1303 1e-44 147.5 In-house 47-285 (305) alignment
Range on Protein: 1068-1303
Range on HMM: 47-285/305.0
YDQTKNRYRDVGAFDHTRVTLqeIPGVPHsHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCY-
 .. ||||.||| .|. || |   .  || .|| ||..    . | .| || | |.|  ||| | ....  .| || ||.|    ||..|..|  .    
qeagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

-----GDIAVRVDRNIELPHYTIRGFKVF----NERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRainsaNDKEEYGPIVVHCSAGVGRTGTIIA
       |.|...   .|   .    ||         . || | | ..|.  |||| |||    .|..|      . .   ||||||||||.||||... 
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.....karpskgpivvhcsagigrtgsvvm

LDIALEQLKLENKVD-IKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|.  |.||   ....  . |.  .|.||.. .|.  ||.|.|. ||.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1068-1321 1.5e-22 74.4 In-house 50-298 (302) alignment
Range on Protein: 1068-1321
Range on HMM: 50-298/302.0
YDQTKNRYRDVGAFDHTRVTLQEIPgvphSHYINANFIKGYHDDKLYIATQGPKEETT---DDFWRMVWEQRTVTIVMLTNLMESYKsKCHQYWP-SSG-
 .  ||.  || . |...| |.. |     .|.||  ..  .  .  | .| || ...   ..|||||.... |..|.|    |  |   ....|  || 
knlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

QCCYGDIAVRVDRnIELPHYTIRGF--KVFNErDTTEKERTVLQfHYTAWPDRNVPAQASHVLDFLRAInSANDKEEYGPIVVHCSAGVGRTGTIIALDI
   ||.. | . . .|  . .   .   |. | . ..   . .. . | |.. .|| . ...      .  |.. .   ..|.    |.|| |....| .
ykeygkmfvNnrk.VekaeeektryviEvlPe.gcsnsvlanvy.vltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav

ALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILediVYGDTAVTIDEFKDRC
|.|.|. .... || ||. .|.|| ..|..|.||.... |.|   .|. . || .| |.. 
aveklqkgkepnikeivksiRsqRpravdslkQyvslyiall...lyikkkvtkpeekkkk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1069-1302 1.1e-71 236.1 In-house 28-265 (274) alignment
Range on Protein: 1069-1302
Range on HMM: 28-265/274.0
DQTKNRYRDVGAFDHTRVTL-QEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC--
 ||||||...   ...||.| .| .  . |.|||||.||||.  .| |.|||||  .| .|||||......  |||||.| |. ..||..|.| . ..  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--CYGDIAVRVDRNIELPHYTIRGFKVFNERDttekERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE--YGPIVVHCSAGVGRTGTIIALDI
   |||. ..|.  .|  .|..| . . .  .    ||.|  . ||.|||...| .|...||... .......|.   .|.|||||||.||||  || .|
serygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
|. ||. |..||. .||. || .|  |||.  || .||.|. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1069-1303 8.7e-65 213.2 In-house 3-237 (237) alignment
Range on Protein: 1069-1303
Range on HMM: 3-237/237.0
DQTKNRYRDVGAFDHTRVTLQEIPGVphSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC-CY
.. |||| .. |.||.|| |.   .   | ||||...||.    | |||.||| | . ||||.|||...   ||||| |.|. . |||.||||. |  .|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIAVRVDRNIELPHYTIRGFKVFNeRDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRA-INSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQL
| ..| . .. |.  ||.| . ... | | .. | . |...|.|||| || |.. .| | .  || ..   | || ..|||||||||| .. .|  | | 
gvltvslkkkeefsdytvrslllsk.rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
| .. |||   |  . ..|  ..|.  ||.|||..|||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1069-1226 1.4e-28 94.6 In-house 33-190 (297) alignment
Range on Protein: 1069-1226
Range on HMM: 33-190/297.0
DQTKNRYRDVGAFDHTRVTLQEipGVPHSHYINANFIKGYH--DDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCC-
   ||||||. |.| ||| |.   ... . ||||...   .   |  || .||| ..| ||||..|.||   .|||...| |  ..||  ||||. |   
slrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

-YGDIAVRVDRN--IELPHYTIRGFKVFNErdttEKERTVLQFHYTAWPDRNVPAQASHVLDFL
  ||. |    .   |  .  .  ....      ...| |    . .|||  ||..   .  | 
kagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfq

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1069-1306 9.2e-20 65.4 In-house 47-280 (303) alignment
Range on Protein: 1069-1306
Range on HMM: 47-280/303.0
DQTKNRYRDVGAFDHTRVTLQEipgvphSHYINANFIKgYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ-CCYG
.  |||. ||  .||..| | .      | || |....  . .|  | || |   |. |||.|. ||.   ...|    |  |   .  .|   .   . 
nmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DIAVRVDRNIELPHYTIRGFKVFNERDTTEKErTVLQFHYTAWPDRNVPAQ-ASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIALEQL
. ..||    ..       .||    . . |   .   || |||  ..|.. .....  .  ..|   |     | |    .|.||.||.  .. |   |
ersirvgefkrvelgdgwvlkvlsvsngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

KLEN-KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
. |.  .|.   .  .|. | . || |.|. ...  . | ..
hseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

Y_phosphatase Protein-tyrosine phosphatase 1070-1303 3.6e-82 270.7 Pfam-A 2-235 (235) alignment
Range on Protein: 1070-1303
Range on HMM: 2-235/235.0
QTKNRYRDVGAFDHTRVTLQEIPGvpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWP--SSGQCCYG
..||||.|. ..|.||| |.. .|  .| |||||..|||...| .|||||| ..| .|||||||.... .|||||.|.|. . ||.||||  ..... ||
kkknRykdilpydktrvklkgseg..psdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIAVRVD-RNI-ELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANdKEEYGPIVVHCSAGVGRTGTIIALDIALEQL
|| |..  ..  .  .||.| ... .. . . ..|.| |.|||.|||..||......||..|.... . ... ||.|||||||||||||..||||.||||
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
. |..||.. ||  ||||| .||| | ||||...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1070-1303 3.6e-82 270.7 In-house 2-235 (235) alignment
Range on Protein: 1070-1303
Range on HMM: 2-235/235.0
QTKNRYRDVGAFDHTRVTLQEIPGvpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWP--SSGQCCYG
..||||.|. ..|.||| |.. .|  .| |||||..|||...| .|||||| ..| .|||||||.... .|||||.|.|. . ||.||||  ..... ||
kkknRykdilpydktrvklkgseg..psdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIAVRVD-RNI-ELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANdKEEYGPIVVHCSAGVGRTGTIIALDIALEQL
|| |..  ..  .  .||.| ... .. . . ..|.| |.|||.|||..||......||..|.... . ... ||.|||||||||||||..||||.||||
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
. |..||.. ||  ||||| .||| | ||||...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0041856 (Phosphotyrosine protein) phosphatases II 1070-1309 5.8e-51 168.0 In-house 2-175 (182) alignment
Range on Protein: 1070-1309
Range on HMM: 2-175/182.0
QTKNRYRDVGAFDHTRvtlqeipgvpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTnlmesykskCHQYWPssgqccygdi
..||||.|.  .||.|          ...|||||.. |.. .. .||||||  .|. ||.||..|..  |||.||         ...|||          
ldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

avrvdrnielphytirgfkvfnerdtTEKERTVLQFHYTAWPDRNVPAqASHVLDFLRAINSandkeEYGPIVVHCSAGVGRTGTIIALDIALEQlklen
                          .. ||...|..|. ||| .||   ...|||......     | ||..||||||||||||..|... ...     
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGD
.|..  .| ..|..| .||. . ||.|.. |.|| . ...
gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_CG42327_pd Subfamily CG42327 1070-1231 2.1e-31 103.7 In-house 29-192 (319) alignment
Range on Protein: 1070-1231
Range on HMM: 29-192/319.0
QTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDK-LYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS----GQC
. |.|. .|  . .|||.||.|.  ....|..|....||.| .  |||.| . |... ||||.||||.. .|| ||.| |    .| .|.|..    .. 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

CYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYtAWPDRNVPAQASHVLDFLRAINS
 |||| | .  .    .| |  . .   |   |. | .  . |  |.. .|||. . ..  |  ..|
lyGdilvtlkgrevkdryaistlll..krvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1070-1175 9.1e-21 69.0 In-house 48-164 (350) alignment
Range on Protein: 1070-1175
Range on HMM: 48-164/350.0
QTKNRYRDVGAFDHTRVTLQE----IPGVPHSH----YINANFIKGY-----HDDKL-YIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCH
 .||||...  ..|.|| |..      .. ||.    |||||..|        . .  |||||.|  .| |||.... .     |..||...|    ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPSSGqccYGDIAVRVDR
.||.  .   | || |..  
rYWqegs...ydditvklas

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1070-1174 3.7e-12 40.2 In-house 49-166 (349) alignment
Range on Protein: 1070-1174
Range on HMM: 49-166/349.0
QTKNRYRDVGAFDHTRVTLQEIP----GVPHSH----------YINANFIK--GYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSK
 .||||.|.  ..|.|| |.. .    .. .|.          |||||..|   .  .| ||||| |   | |||....  ..   .. |..  |    |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHQYWPssgQCCYGDIAVRVD
|..||    .  | .| |.. 
cdiywq...elsysnitvklq

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1072-1154 1.1e-08 29.0 In-house 37-118 (332) alignment
Range on Protein: 1072-1154
Range on HMM: 37-118/332.0
KNRYRDVGAFDHTRVTLQEIPGvpHSHYINANFIKGYHDDKLYIATQGPKEETTD-DFWRMVWEQRTVTIVMLTNLMESYKSKC
 ||   . .|||.|| |    |  .  . ||... ||     || .| | .. |.  ||||| |..   |... .. |  | |.
mnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1073-1324 6.3e-22 73.0 In-house 23-269 (290) alignment
Range on Protein: 1073-1324
Range on HMM: 23-269/290.0
NRYrDVGAFDHTRVTLQEIPGVPHSHYINANFIKgYHDDKLYIATQGPKEET-------TDDFWRMVWEQRTVTIVMLTNLMESYKS----KCHQYWPSS
.|. .|  . .||| |..      . || ||... . ..   |.|| |.|..         .|| |. . .   .||| . .|  .      | .| | |
qRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

G--QCCYGDIAVRVDRNIELPHYTIRGFKVFNErdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINsandkEEYGPIVVHCSAGVGRTGTIIALD
   .  .... |.    ..     .|   |  .    |.| ||    .  | ..||. .   .|. .. ..      .  |..|||  |. |  .. |..
vgeelkfkgltvkCkskekeddvetRelvvkfd...deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaii

IALEQLK-LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILedivygdtaVTIDEFKDRCMKL
..   .  ....| .. ..  ||||| ....   .. |.  .|.         . . |..|. .. 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqfaee

0044763 (Phosphotyrosine protein) phosphatases II 1081-1300 7.2e-39 128.6 In-house 2-166 (178) alignment
Range on Protein: 1081-1300
Range on HMM: 2-166/178.0
FDHTRVTLQEIPGVPHSHYINANFIKGYhddkLYIATQGPkeettDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQccygdiavrvdrnielp
.|.||| |....|.. | ||||..| ..    ||.....|      |......|.   .||.||. .| .. ||..|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

hytirgfkvfnerdttekertvLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPIVVHCSAGVGRTGTIIALDIALEQlklenKVDIKGIVTFL
                      .|.... .|| .||   .|.|.|...|..| |... ||..|||||||||.||..|... ...     ....  .. ..
......................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RKQRKqMVQALCQYIFIHNA
|..|  .|.   |. ...  
rerRp.ivpnpgqlrqLyef

0046846 (Phosphotyrosine protein) phosphatases II 1088-1302 2.6e-44 146.4 In-house 3-170 (176) alignment
Range on Protein: 1088-1302
Range on HMM: 3-170/176.0
LQEIPGVPHSHYINANFIKGYhddkLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYgdiavrvdrnielphytirgf
|...   ....|||||.| |.    ..|||||| ..|. ||..|..|..  ..|.||...|  . ||..|||   .  .                     
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvfnerdttekertvlQFHYTAWPDRNVPAQaSHVLDFLRAINSANDKEeyGPIVVHCSAGVGRTGTIIALDialeQLKLENKVDIKGIVTFLRKQRK-Q
                |.... ||| .||   ...|..|..|..| ..   ||..||||||.|||||..|..     |.||. ...  .. ..|.||  .
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQALCQYIFIHNAIL
.||  .|| |.. ..|
avqtpeQyrflyefel

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1091-1212 2.3e-07 25.2 In-house 7-123 (130) alignment
Range on Protein: 1091-1212
Range on HMM: 7-123/130.0
IPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESykskcHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVF
.  ..  .||||.|.      . |. || |  .|. |||.|. |.    .|.|  . |       .||| |    . .  . |          |.  .. 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnle

NERDTTEKERTVLQFHYTAWPD
 |.|  |  ...  |. . || 
iesdlneshqaltmfqisnwps

0051429 (Phosphotyrosine protein) phosphatases II 1094-1304 7.7e-54 178.4 In-house 1-224 (272) alignment
Range on Protein: 1094-1304
Range on HMM: 1-224/272.0
VPHSHYINANFIKGYHD---DKLYIATQGPKEETTDDFWRMvWEQRTVTIVMLTNLMESYKSKCHQYWP------------SSGQCCYGDIAVRVDRNIE
.| |.||||....||.    ........|| . | .||||. .|..  |||.|....|  . ||..|||            |  .  ||.. |..   . 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPHYTIRGFKVFNERDTTEKeRTVLQFHYTAWPDRNVPAQAshVLDFLRAINSandkeeYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVD------
|..|..| . . .. ...|  |.|...|||.|||..|| .|  .|..|.....       ||..||||||..||||..||.. |... ||  ||      
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IKGIVTFLRKQRKQMVQALCQYIFIHNAILED
  . ..|  ||.|| ..||   ||.|...|.|| 
lyleeaveelraqrpgavqteeqylflyeallel

0043147 (Phosphotyrosine protein) phosphatases II 1095-1298 1.2e-43 144.2 In-house 3-154 (172) alignment
Range on Protein: 1095-1298
Range on HMM: 3-154/172.0
PHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLmesykskchqywpssgqccygdiavrvdrnielphytirgfkvfnERD
..|.||||.....|.  . .||||||  .|..|||||..|.   .||.||.|                                             . |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

TTEKERTVLQFHYTAWPDRNVPaQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALeqlkleNKVDIKGIVTFLRKQRKQMVQALCQY
..  ||...|..|. ||| .||  ....|.||. |...  ... ||..||||||||||||..|... |       ....  .| ..|..| ..||   ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIH
.|..
rfly

0051082 (Phosphotyrosine protein) phosphatases II 1095-1302 5.2e-38 125.3 In-house 1-150 (151) alignment
Range on Protein: 1095-1302
Range on HMM: 1-150/151.0
PHSHYINANFIKGYhddklYIATQGPkeetTDDFWRMVWEQRTVTIVMLTNLMESYksKCHQYWPSSGqccygdiavrvdrnielphytirgfkvfnerd
|.|.|||.... |.     .....||    ..||.....|.   |||.|....| .  .|..|.|. |                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ttekeRTVLQFHYTAWPDRNVPAQASHVLDFLRAINSandkEEYGPIVVHCSAGVGRTGTIIALDIALEQlklenkVDIKGIVTFLRKQRKQMVQALCQY
     ..||..... ||| ..|     ||.||.....     . ||..||||||.|||||..||.. |..      |..  .. ..|..|  .||   |.
.....ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

IFIHNAIL
.|.. |.|
lfqlfall

0036282 (Phosphotyrosine protein) phosphatases II 1097-1298 1.2e-46 154.0 In-house 2-163 (174) alignment
Range on Protein: 1097-1298
Range on HMM: 2-163/174.0
SHYINANFIKGYHDDKLYIATQGPKEettddFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSsgqccygdiavrvdrnielphytirgfkvfnerDTT
|.||||.......  . .||.||| .     ||.|..|..  |.|||....|  . ||..|||.                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

EKERTVLQFHYTAWPDRNVPAQAShVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKlENKVDIKGIVTFLRKQRKQMVQALCQYIF
  ||...|..|. |||..||  .  .|.|......|  . . ||..||||||||||||..|... | .|. |. ||.  .|  ||.|| .|||   ||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IH
..
ly

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1097-1305 4.2e-06 19.6 In-house 101-309 (346) alignment
Range on Protein: 1097-1305
Range on HMM: 101-309/346.0
SHYINANFIKGYHDDKLYIAT--QGPKEETTDDFWRMVWeQRTVTIVMLTNLMESYKSKCHQYW-PSSGQCCY-GDIAV---RVDRNIELPHYTIrgfKV
 | .   |.    . || .|   |  .|   .||| |.. |  . .| |    .  |      .    |   | | . .   | |   .   |||   .|
vhlvvlyfvifqfehklivaqlpqmenesfvedfwymiy.qeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeyti...ev

FNERDTtekERTVLQF-HYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVhCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMV
. | ..   .  . |  |.. |   . | ..  .. ..  . | .. .. |  ||    | ||. ..|    |..||    . .|  |.  ...||   |
lpegns...dsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggv

QALCQYIFIHNAILEDI
... ||  |.  ... |
esfaqyasiyaivfdyi

0049260 (Phosphotyrosine protein) phosphatases II 1104-1298 7.6e-42 137.9 In-house 1-143 (152) alignment
Range on Protein: 1104-1298
Range on HMM: 1-143/152.0
FIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWpssgqccygdiavrvdrnielphytirgfkvfnerdttekertvl
||.||.  . .|||||| ..|..|||||..|.   ||||||.|.| .| ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFHYTAWPDRNVPAQASHVLDFLRAINSAnDKEEYGPIVVHCSAGVGRTGTIIALDIALeqlkleNKVDIKGIVTFLRKQRKQMVQALCQYIFIH
|.... ||| .||  . ..|..|..|. .  ... ||..||||||||||||..|... |      ..|... .| ..|..|...|.   |..|..
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1106-1163 9.7e-09 29.0 In-house 230-284 (440) alignment
Range on Protein: 1106-1163
Range on HMM: 230-284/440.0
KGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMEsykSKCHQYWPSSGQ
.||   . .|||| | . |  ||||.| . |  ||.|| .| .     |  |||   .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntr

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1111-1298 2e-26 87.4 In-house 4-197 (199) alignment
Range on Protein: 1111-1298
Range on HMM: 4-197/199.0
DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYT
.. ||||| |  ||  |||.||||  .  |||. .     ..    |||.  ||   || ..| .      | |||  . . |.  .    | . .. .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDRNVPAQASHVlDFL---RAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKL--ENKVDIKGIVTFLRKQRKQMVQALCQYIFIH
.| ..  |  |  |  |.   | .    ..|   |..|||| | | || ..|||| .   .      ||.  .   ||. |  .. .| .| ||.
swkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1112-1298 2.2e-26 87.3 In-house 4-196 (198) alignment
Range on Protein: 1112-1298
Range on HMM: 4-196/198.0
KLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTA
. ||||| |  ||  |||.||||  .  |||. .     ..    |||.  ||   || ..| .      | |||  . . |.  .    | . .. .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDRNVPAQASHVlDFL---RAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKL--ENKVDIKGIVTFLRKQRKQMVQALCQYIFIH
| ..  |  |  |  |.   | .    ..|   |..|||| | | || ..|||| .   .      ||.  .   ||. |  .. .| .| ||.
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1118-1301 3.9e-23 76.3 In-house 97-284 (302) alignment
Range on Protein: 1118-1301
Range on HMM: 97-284/302.0
QGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVR-VDRNIELPHYTI-RGFKVF-----NERDTTEKERTVLQFHYT
  || .|.. .| .. . ..  .| |....|. . || .|.     |.  .|  .|. |. . .| ..|  ..||..     ||. ......||  ....
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDRNVPAQASHVLDFLRAINSANDKeeygpIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAI
||||   |..| . || |.  .|   .     ..||||||||||||..|.   ..  . ..  |.  ||. .|. |   ||   | |..   .
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1124-1311 5.3e-18 60.0 In-house 40-226 (255) alignment
Range on Protein: 1124-1311
Range on HMM: 40-226/255.0
TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRniELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASH
| | |....  ..| ..|||... |  . ||..|.|    ..  . |..| . .     .  .|  ..  .     | .||  ..|. |...| | .|  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLDFLRAINSAndKeeygPIVVHCSAGVGRTGTIIALDIALE----QLKLEN--KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILeDIVYGDTA
.|  |...  .  |    ..|||||.|.||. . .  ...      .|.  .  ..| . ... ||..||. ..   |  |    .| |.|.  ..
ilnilkvvrds..k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl.dlvfpkge

subfamily_hpo-7_pd Subfamily hpo-7 1124-1302 5.9e-14 46.6 In-house 46-224 (263) alignment
Range on Protein: 1124-1302
Range on HMM: 46-224/263.0
TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIElpHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASH
| | |....  ..| ..|||..  |  . || .|.|    ..  . ...| . . ..     ..  .. .  .   | .|| .. |. |...| | .|  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLDFLRAINSAndKeeygPIVVHCSAGVGRTGTIIALDIALE----QLKLENK--VDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
.|  |..      |    ..|||||.|.||.      ...      .|.  .   .|   ... ||..||. ..   |  |    .|
ilnilkvarns..k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

subfamily_PTEN_pd Subfamily PTEN 1185-1295 6.9e-07 24.4 In-house 60-170 (184) alignment
Range on Protein: 1185-1295
Range on HMM: 60-170/184.0
RGFKVFNERDTTEKERTVLQFHYTAWP-DRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIaLEQLKLENKVDIKGIVTFLRKQ
  .|..| |   . . . .. . . .| | . |.. . . .... |..  ....   .|||| || ||||..|.  . |..|.||.. ... . .  | .
dhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayl.lkslllekaeealelfaeaRtk

RKQMVQALCQYI
 |. |.   |  
nkkgvtiPsqrR

0048076 (Phosphotyrosine protein) phosphatases II 1189-1301 2.3e-27 90.8 In-house 36-139 (145) alignment
Range on Protein: 1189-1301
Range on HMM: 36-139/145.0
VfnERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeyGPIVVHCSAGVGRTGTIIALDIALEqlkleNKVDIKGIVTFLRKQRKQMV
.   ....  ||...|..|. |||..||  ....|.||..|..| ...  ||..||||||||||||..|... |.     ..|..  .. ..|.|| ..|
l..tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

QALCQYIFIHNAI
.   |..|.. ..
pnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 1189-1299 4.3e-27 90.0 In-house 36-139 (144) alignment
Range on Protein: 1189-1299
Range on HMM: 36-139/144.0
VFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeyGPIVVHCSAGVGRTGTIIALDIALeqlklENKVDIKGIVTFLRKQRKQMV
. .|.. .. ||...|.... |||..||  ....|.||..|..| ...  ||..||||||||||||..|... .     ....... .. ..|..| ..|
lteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QALCQYIFIHN
.   |..|...
pnpgqlrfLle

PTEN_1 1191-1257 9e-10 33.7 In-house 83-149 (196) alignment
Range on Protein: 1191-1257
Range on HMM: 83-149/196.0
NERDTTEKERTVLQFHYTAWPDRNVPAQASHvLDFLRAINSANDK-EEYGPIVVHCSAGVGRTGTIIA
...| .| ..  ....   ..| ..|  ... .|... . ..  . .. . ..||| ||.||.||..|
rsydleeffksgveylhfpieDhgapslsel.fdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

0038934 (Phosphotyrosine protein) phosphatases II 1194-1258 2.6e-11 39.0 In-house 71-135 (194) alignment
Range on Protein: 1194-1258
Range on HMM: 71-135/194.0
DTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIAL
|..| |.  ....   .||.... . . .|.||....  ... . | ..||| ||.|||||..| 
dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

PTPc_motif_SM00404 1196-1286 1.1e-06 23.6 In-house 43-123 (140) alignment
Range on Protein: 1196-1286
Range on HMM: 43-123/140.0
TEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAInsandKEEYGPIVVHCSAGVGRTGTIIALdialEQLKlENKVDIKGIVTFLRKQRKQ
 ......||         .. .. . ||||....     ... | ..||| ||| |..|.|.     . .. .......  . |....|..
ensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliia....Ylmr.yrqlslaeayefvkerRpi

subfamily_PRL_pd Subfamily PRL 1196-1289 3.1e-06 21.3 In-house 49-135 (151) alignment
Range on Protein: 1196-1289
Range on HMM: 49-135/151.0
TEKERTVLQFHYTAWPDRNVPAQAsHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIaleqlkLENKVDIKGIVTFLRKQRKQMVQ
.. |.. .. .  |. | .||...  | ..|. ....  .|    . ||| ||.||.  ..|| .      .|. .. .  | |.|..|.  . 
eklekegievldlafddGavPpee.vveeWlellkekfkeepkstvavhcvaGlGraPvlvalal......ieaGmkyedavefirekrrgain

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1198-1328 3e-31 103.2 In-house 87-217 (440) alignment
Range on Protein: 1198-1328
Range on HMM: 87-217/440.0
KERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFI
. ||. |.|| .|||. ||  |. || ... .| ...|   ||..||||||.|||| |||.|  | . |  ...||  ..  .|..| ||||.  || |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HNAILEDIVYGDTAVTIDEFKDRCMKLQEPT
|.|.|| .. ||| .  |.  .|  ..| | 
heavlegllcgdtliledditerveqiqwpn

PTPc_DSPc_SM00012 1201-1303 4.8e-36 118.5 In-house 1-105 (105) alignment
Range on Protein: 1201-1303
Range on HMM: 1-105/105.0
TVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIALEQLKLE-NKVDIKGIVTFLRKQRKQMVQALCQYIFIH
|| ..|||.||| .|| .....|..|||... . |.|  .|.|||||||||||||..||||.|.||. | ..|||. ||  ||||| .||| . ||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

NAILE
.|.||
ralle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1201-1303 7.7e-14 45.8 In-house 219-342 (349) alignment
Range on Protein: 1201-1303
Range on HMM: 219-342/349.0
TVLQFHYTAWPDRNVPAQA----------SHVLDFLRAINSaNDKEEYGPIVVHCSAGVGRTGTIIALDIALE----------QLKLENKV--DIKGIVT
 .||. .  |.|  .              ....| | | .   |...  ...|||||| ||||... ||. |.          ..||...    |  || 
ellqlqvknwldlslllnPisilqalevkndliddlfarly.ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

FLRKQRKQMVQALCQYIFIHNAILE
 ||||| .||| | |.|.|..|.|.
elrkqrismvqnlaqfiaiyealLk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1202-1302 3.7e-17 57.1 In-house 217-341 (350) alignment
Range on Protein: 1202-1302
Range on HMM: 217-341/350.0
VLQFHYTAWPDRNVPAQASHV----------LDFLRAiNSANDKEEYGPIVVHCSAGVGRTGTIIALDIALE-------------QLKLENKV--DIKGI
|.|...  |.| ..  .   .          .| | | .|  |...  ||.||||||||||||...||  |.             .|.  .|.   |. |
vyqlqvknWkDlslllnPesilqalevkndliddlfa.eshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VTFLRKQRKQMVQALCQYIFIHNAIL
|  ||||| .||| | |.|||..|.|
vnelrkqrismvqnldqfifiYeall

subfamily_PTPDC1_pd Subfamily PTPDC1 1202-1297 1.6e-09 32.4 In-house 82-168 (182) alignment
Range on Protein: 1202-1297
Range on HMM: 82-168/182.0
VLQFHYTAWPDRNVPAqASHVLDFLRAINSANDKEeygPIVVHCSAGVGRTGTIIALdialeQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFI
 . ..  .|.| .|..   ..||  . ...| ...    . ||| || |||| .||       |   .... .  ....|..| . .|.  |  ..
giyvynfgwkDygvas.leriLdivkvvafalqeg...kvavhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqvelv

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1205-1303 9.6e-06 19.3 In-house 232-333 (347) alignment
Range on Protein: 1205-1303
Range on HMM: 232-333/347.0
FHYTAWPDRNVPAQASHVLDFLRAINS---AN---DKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRkqmVQALCQYIFIH
.  |.|| .. | .  .|| ..||      .    . |   |.|| |  |. |. |..   | .||.   .  |   .   .| ||      .   ||  
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqr...agvftmsifyt

NAILE
 ||  
yaira

subfamily_DSP23_pd Subfamily DSP23 1210-1290 4.7e-07 24.6 In-house 59-131 (148) alignment
Range on Protein: 1210-1290
Range on HMM: 59-131/148.0
WPDRNvPAQASHVLDFLRAINSANDKEEygPIVVHCSAGVGRTGTIIALDIALEQlklenKVDIKGIVTFLRKQRKQMVQA
 .|   |     | .|.| .. |..|.|   . |||  | |||||..|  .  |.     |.     .. .|..|   |..
iddyh.ppaleqvvefvrvveeaeekne..avsvhcllgrgrtgtmlacylvker.....klaaaeaiaevrrlrpgsvet

subfamily_CDC14_pd Subfamily CDC14 1214-1293 6.6e-07 23.5 In-house 245-313 (328) alignment
Range on Protein: 1214-1293
Range on HMM: 245-313/328.0
NVPAQAsHVLDFLRAINSAndkeeYGPIVVHCSAGVGRTGTIIALDIaLEQLKLenkvDIKGIVTFLRKQRKQMVQALCQ
 .| .|  |  ||.....|      | |.||| ||.|||||.||  . ... ..      . ....||  |  .| .  |
stPsda.ivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacyl.mkhyrf....taaeaiawlricrPGsvigpqq

subfamily_CG42327_pd Subfamily CG42327 1232-1301 8.1e-20 65.7 In-house 241-311 (319) alignment
Range on Protein: 1232-1301
Range on HMM: 241-311/319.0
ANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLE-NKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAI
.  .|..||.||||| ||||||..|| |||...|.   . |||  .| ..|..| . |..  || ||.. .
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1240-1305 9.1e-14 46.0 In-house 230-295 (297) alignment
Range on Protein: 1240-1305
Range on HMM: 230-295/297.0
PIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
...|||||||||.| ..  |. |..|. .   |.. |...||.|| ..||.| |. ....|.|. .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1241-1306 1.4e-16 54.6 In-house 1-66 (69) alignment
Range on Protein: 1241-1306
Range on HMM: 1-66/69.0
IVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
.|||||.| |||||.||. . . ..| |  |||   | ..|| |  ||    .|||||.|. | . 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1242-1308 1.2e-15 51.6 In-house 1-67 (69) alignment
Range on Protein: 1242-1308
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYG
|||||.| ||||| ||. . . ..| |  |||   | ..|| |  ||    .|.|||.|. | .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

0050432 (Phosphotyrosine protein) phosphatases II 1310-1571 1.3e-30 102.2 In-house 24-303 (308) alignment
Range on Protein: 1310-1571
Range on HMM: 24-303/308.0
TAVTIDEFKDRCMKLQEPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFeTDKDSKFTSYYLDGY--WTPNLFIKSPSPTKETEE
. ......  ...|. ...|..|||... ||||. .                   .   | |    ....     | |||  . |. ||   .|...| |
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntve

LFWRLIVQNECTHIINLSPAD----ITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKF
 |||.. ......|. |   .    .. . | |...|.  |..|..|| . . . . .. .| . . | .|. ..... ..|      .. | .. ...|
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

IQGCLVEAeschrGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDKLL
.. .         ...||..|     |  | |..| ..|.. .||. .|...  ..   | || . ... | ..|..||||  ..|
lelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0051299 (Phosphotyrosine protein) phosphatases II 1310-1566 1.5e-28 95.5 In-house 3-285 (288) alignment
Range on Protein: 1310-1566
Range on HMM: 3-285/288.0
TAVTIDEFKDRCMK--LQEPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFETDKDSKFTSY----YLDGYWTPNLFIKSPSPTK
|.. ..|. ....|  .  .|.. |||... |..|. .                   .   | | . . ... ...|    |.|||.... ||    |..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE----EDSSTLKLKYIQYQEMLLKQCFP
.| | |||.. ......|. | . .    .. . | |.   .  |..|..||   . . . .. .| . . |      |. ... . ..|      .. .
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

RADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
 .. ...|.. .    .    |..|...|     |  | |..| ..|.. .||. .|.|.  ..   | ||.. ... | ..|..||||
spellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0039614 (Phosphotyrosine protein) phosphatases II 1311-1569 2.3e-28 94.9 In-house 15-291 (297) alignment
Range on Protein: 1311-1569
Range on HMM: 15-291/297.0
AVTIDEFKDRCMKLQEPTLINEEFNKIGSVKPPAQACPGP----------------SIVPFETDKDSKFTS-----YYLDGYWT-PNLFIKSPSPTKETE
 ... ..  ...|. ..||. .|| .. |.||.   .  |                | | . . ... . |      |.|||.  .. || .  |..|| 
plsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

ELFWRLIVQNECTHIINLSPADIT---TYSYIPPDVGdrqlKFGPLTVSVGRKQFNTGFSTRDISIFNeeDSSTLKLKYIQYQEMLLKQCFPRADKFIKF
| |||.. .. .|.|..| . .      ..| |...|    ..|..|| . . . . |. .| ... |  .. ..... .||  .   .. | .. ...|
edFwrmvweqgvtvivmLtklvelgrkcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

IQGCLVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDK
.. .    ... ....|.|.|  .  |  | |... ..|.. .||. .|.|.  ..   |.|| . ....| ..||.|||.  .
lelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0047943 (Phosphotyrosine protein) phosphatases II 1322-1566 4e-31 103.9 In-house 6-271 (273) alignment
Range on Protein: 1322-1566
Range on HMM: 6-271/273.0
MKLQEPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFETDKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHI
.||  .||. |||... |.||.                     .   | |  . ....     |.|||.... ||    |...| | |||.. .. ...|
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

INLSPAD----ITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESCHRG
. | . .    .. . | |...|.  |..|..|| . . . . .. .| . . | ... ... ....| .    .. |  . ...||. .    |.....
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

nHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
 .|...|  .  |  | |..| ..|.. .||. .|.|.  ..   | || . ....| ..|..||||
.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0045450 (Phosphotyrosine protein) phosphatases II 1323-1566 1.6e-27 92.5 In-house 22-303 (307) alignment
Range on Protein: 1323-1566
Range on HMM: 22-303/307.0
KLQEPTLINEEFNKIGSVKP--------------------PAQACPGPSIVPFETDKDS-------------KFTSYYLDGYWTPNLFIKSPSPTKETEE
.|  .|.. .||.|. ||..                    .   .   . | . . ..|              .  ..||||. .. ||   .|..|| |
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

LFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE-EDSSTLKLKYIQYQEMLLKQCFPRADKFIK
 |||.. .. .|.|..|.. .    .  . | | .  . .| .|..|| . ...   |.  | . . .  ... ........| .    .. |  . ...
dFwrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

FIQGCLVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERI---IDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
||. ..   |.. ....|.|.|  .  |  | |... ..|.. .|| .   .|||.  ..   |.|| . |...| ..|..|||.
fieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0036941 (Phosphotyrosine protein) phosphatases II 1326-1567 3.8e-29 97.3 In-house 11-277 (297) alignment
Range on Protein: 1326-1567
Range on HMM: 11-277/297.0
EPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFETDKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS
 ..|. .|| .. .....                     .   . | .. .... .   |.|||. .. ||    |...| | |||.. .. .|.|..|.
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

PADI----TTYSYIPPDVGDrQLKFGPLTVSVGRKQF--NTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAeSCHRGNH
. .     . ..| |...|.  |..|..|| . . .   .... .| . . . ... ........|       . . .. ...||. ..    .  ....
elvelgrekcaqywpleege.sltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsgg

PILIHDDGSNGPVGIFATLAYCLQRAK---KERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYS
|.|.|  .  |  | |... ..||. .   ||. .|.|.  ..   |.|| . .|..| ..|..|||. 
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0043336 (Phosphotyrosine protein) phosphatases II 1347-1566 2.2e-28 95.0 In-house 56-276 (278) alignment
Range on Protein: 1347-1566
Range on HMM: 56-276/278.0
CPGPSIVPFETDKDSKFTSYY----LDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPpdvgDRQLKFGPLTVSVGRK
.   | | .. ..    ..|.    .|||. |. || .  |..||.| |||.. .. .|.|..| . .    .. . | |    .  |..|..|| . . 
pydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp....ggsltygdftvtllke

QFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLlKQCFP-RADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQ
. . .. .|.. . |  |. ...   ..|  .   ...|   . ...|..  .   |     |.|.|.|  .  |  | |..| ..|....||. .||..
ehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdlee

SANHHYLQCPGLIVNLQFYAYCYDCLLEY
  ..   |.|| . ....| ..|..||||
avkelreqRpgavqtpsqyrflyealley

subfamily_PTPRK_pd Subfamily PTPRK 1350-1566 3.6e-17 57.2 In-house 60-276 (314) alignment
Range on Protein: 1350-1566
Range on HMM: 60-276/314.0
PSIVPFETDKDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvGdrQLkFGPLTVSVGRKQFNTGF
. ... . | .|..  . ..|.|  |. ||    | .|| . ||||. ...|. |. |.       .  . | | | .  .  .|.. | . . . .. .
vflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.t..ev.ygdikvelvetellael

STRDISIFN--EEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESchrGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHH
 .|  .. .     . . ... .|.      .    |  ..|...      |    .. .|..|     |  |.| ...  |. ...|...|. . .   
vvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktl

YLQCPGLIVNLQFYAYCYDCLLEY
  . . ..   . | ..|| .|| 
rsrkvnmveteeqykfiydvilea

0040439 (Phosphotyrosine protein) phosphatases II 1351-1566 6.6e-29 96.7 In-house 26-245 (249) alignment
Range on Protein: 1351-1566
Range on HMM: 26-245/249.0
SIVPFETDKDSKFTSY----YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNT
| |  .  ..   ..|    |.|||. .. ||    |..|| | |||.. .. .|.|..|.. .    .. . | |.   .  |..| .|| . . . . 
srvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsleygdftvtllsvevkd

GFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHH
.. .| . . | .|..... . |||  .   .. |  . ...||. ..   |.. . ..|.|.|  .  |  |.|... ..|.. .||. .||..  .. 
dytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll

YLQCPGLIVNLQFYAYCYDCLLEY
  |.|| . |...| ..|..|||.
rsqRpgavqnpeqyrflyeallel

0042113 (Phosphotyrosine protein) phosphatases II 1351-1566 2.7e-26 87.9 In-house 24-242 (245) alignment
Range on Protein: 1351-1566
Range on HMM: 24-242/245.0
SIVPFETDKDSKFTSYY----LDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNT
. | .  |. . ...|.     |||. .. || .  |..|| | |||.. .. .|.|..|.. .    .. . | |.   .  |..| .|| . . . . 
trvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...gesltygdftvtllseehld

GFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKF---IQGCLVEaeschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSA
.. .| ... |. |. ...   ..|  .   .. .  . ...|   .. .| |      .|.|.|.|  .  |  | |... ..|....||. ..| .  
dytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeav

NHHYLQCPGLIVNLQFYAYCYDCLLEY
 .   |.|| . ....| ..|..|||.
kelrsqRpgavqtpsqyrflyeallel

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1351-1574 6.6e-18 59.7 In-house 48-266 (267) alignment
Range on Protein: 1351-1574
Range on HMM: 48-266/267.0
SIVPFETDKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTY-SYIPPDVGDRQlKFGPLTVSVGRKQFNTGF--STR
..|.. | ..    . |..|| | | ||    | | |   |. .| ..... |. | .. .     . || .|. . |.  |||    .. .  .   | 
trvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqak.kyqdltvehslekeendyqiitl

DISiFNEEDSSTLKLKYiqYQEMLLKQcfpRADKFIKFIQGCLVEAeSCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCP
..  |..| .  . | |  |..  ..        ..| . | | .      ||.|.... .   |  | | ..   |.|||.| . |. .   .   | .
elk.fknesahnvtlyy..ykkwnint...nnkpylkplfgilakn.qlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqri

GLIVNLQFYAYCYDCLLEYSDKLLKEE
||.  .. | |... | ||..  ||||
glvdtkeryiyihellaeyaegrlkee

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1356-1565 3.5e-18 60.6 In-house 72-277 (315) alignment
Range on Protein: 1356-1565
Range on HMM: 72-277/315.0
ETDKDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE
|.|..|..  . ..|||  .. .| . .|  .. . ||||. ......|. |.       .       |... .|..||.   .. || .. | .|.  .
endphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfg

E-DSSTLKLKYIQYQEMLLKQcfpRADKFIKFIQGCLVEAESCHrgnHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNL
.     ..|.|  . .| . .    .  ....|.   .  ..      .|..| .   |  | | ||   |..|. |..||. .  .    .  ...  .
dnirevvqlhytswpdmgvpk...ytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

QFYAYCYDCLLE
. | . || |||
eqyqfiydalle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1356-1567 1.1e-12 42.8 In-house 68-288 (325) alignment
Range on Protein: 1356-1567
Range on HMM: 68-288/325.0
ETDKDSKFTSY----YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS---PADITTYSYIPPDVGDRQlKFGPLTVSVGRKQFNTGFSTRD
|| ||.  . |    ||  .   . |. . .|  .| . .|||... .|. .. |      .     | | ..|. . .||.| |..   .  . .  | 
etkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksk.tfGglevklrtieeisdyvhrv

ISIFNEEDSSTLKLKYIQYQEML--LKQCFPRA-DKFIKFIQGCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQ
. . . ..  |. .|  |.|       | .| .   ... ..       .  ..  |||.|     |  |.|..|   |..  .|  .|.... ..   .
ldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkd

CPGLIVNLQFYAYCYDCLLEYS
 | ..     |  .|..| |. 
rpsmvetvdqyiliyealveay

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1357-1568 2e-18 61.5 In-house 33-243 (250) alignment
Range on Protein: 1357-1568
Range on HMM: 33-243/250.0
TDKDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHII---NLSPADITTYSYIPPDVgdrQLKFGPLTVSVGRKQFNTGFSTRDISIF
.||.| .  . .|.||   ..|| . .| ..| | |||...... . |.   ||.  . |   |.| ..     |.| .|||.  |.  . . .| . . 
gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek...aekyGdvtvsllskeefadytkrklkls

NEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVN
... ..   .. ...     |     |   .....   |.|.  . || |....     |  | | ..   |.|.|||...|. .  .    . |. .  
kakkaderivrqlhfvvWPdkgvPevatavLellkk..vqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphaves

LQFYAYCYDCLLEYSD
|. | ..|  .|.. |
leqyvfvyeiilkald

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1358-1568 1.5e-17 58.5 In-house 69-279 (287) alignment
Range on Protein: 1358-1568
Range on HMM: 69-279/287.0
DKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPDVGdrqLKFGPLTVSVGRKQFNTGFSTRDISIFN
 ..    . ..|||   . || . ||  .|   ||.|| ... | |. |.      .   | | | .     . .|. ....  .. |.|.  |.. . |
ehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvlGeyniellneevnagyierklevkn

EEDsSTLKLKYIQYQEMLLKQC--FPRADKFIKFIQGCLveAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIV
..  .. |..  |||    ..    ..    .  |.      .  .||| .|..|   . |  ..|   |  ....|.| .||..|  ..   | || . 
knk.agdkqqvkqyqitnWdstgkvtepqtillvieemy..ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvq

NLQFYAYCYDCLLEYSD
  . | . .| .||| |
tveqykfindivleyld

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1359-1567 2e-20 68.3 In-house 82-290 (298) alignment
Range on Protein: 1359-1567
Range on HMM: 82-290/298.0
KDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP---ADITTYSYIPPDVGDRqlKFGPLTVSVGRKQFNTGFSTRDISIFNE
..| .    .|..|   | || .  | .|| | |||...... . |. | .    | |.|.   ||.| .  ..| .|||. .|.  . . .| . . ..
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskk

EDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQ
. ... ... ... .   |.    |   .....   |.|   . ||.|....     |  | |  .   |.|.|||. .|..|  .    . ||..   .
keekerevrqlhftsWpdkgvpenatsvldllrk..vrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

FYAYCYDCLLEYS
 |...|.  ||. 
qYvfiyeavleal

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1359-1567 5.9e-19 63.3 In-house 72-280 (318) alignment
Range on Protein: 1359-1567
Range on HMM: 72-280/318.0
KDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADIT----TYSYIPpdvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFN
..| .  . |.|||   . .| . .|  || | |||.. . ... |. |.            | |   ..   ..| |.| .  .   . .  | ... .
egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP...skgsrsygklvvelkeevelsdyvlrefkvtr

EEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNL
.| ... . .  .| .   .     . .......   |..   . |..||..|  .  |  |.| ..   |.|.|.| ..|..|  ..   | . ..   
teeeesrqvrqyhytsWpdegvpesgaslldlvrq..vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

QFYAYCYDCLLEYS
. | ..|| |||. 
dqyefiydvlleal

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1360-1566 1.5e-21 71.9 In-house 73-282 (305) alignment
Range on Protein: 1360-1566
Range on HMM: 73-282/305.0
DSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS----PADITTYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFN-
||..  . |.|||   . .| . .| |.| . ||||||.   ..|. |.      .   . | |  ... . .||...| .  ..  ... .|...| . 
dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte.kkefgefsvelksektasdyieRklkisie

EEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQgcLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNL
.||. .  .   |  .   .     |  ....|.   |. .  .  . |.|.|   . |  |.| ..   |.|.||| ..|. .  ..   . .... .|
dedkesrtvlqyqltdWPdhGvpqfatsllslik..rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

QFYAYCYDCLLEY
. | ...| | |.
dqYvflhdaldel

0046846 (Phosphotyrosine protein) phosphatases II 1360-1568 4.5e-08 28.6 In-house 8-174 (176) alignment
Range on Protein: 1360-1568
Range on HMM: 8-174/176.0
DSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD---ITTYSYIPPDVGDRQLkfgpltvsvgrkqfntgfstrdisifneed
.  . .| .....  ...|    |. .| . |.... .. .|...||            ...|.. . ..                              
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

sstlKLKYIQYQEMLLKQCfPRADKFIKFIQGCLveaeschRGNHPILIHDDGSNGPVGIFATLAyclqRAKKERIIDLLQSANHHYLQCP-GLIVNLQF
    . ...   ..   .     .....||. .|       . ..|.|.|  .  |  | .. .       ..|. .....   .   | | | . . ..
....qylhlpwpDhgvpdl.elllellefireal.......keggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YAYCYDCLLEYSD
| ..|...|.. .
yrflyefellllk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1361-1420 1.4e-14 48.4 In-house 77-135 (439) alignment
Range on Protein: 1361-1420
Range on HMM: 77-135/439.0
SKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAdITTYSYIPPD
  ... |..||....|.|... |.||| . ||||.... ...|..|.   . .| | | |
hyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl.vesykywpsd

subfamily_CG7180_pd Subfamily CG7180 1362-1566 3.2e-19 63.7 In-house 72-289 (296) alignment
Range on Protein: 1362-1566
Range on HMM: 72-289/296.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP-ADITT--YSYIPPDVgdrQLKFGPLTVSVGRKQFNTGFSTRDISIFNE----
   . | |..  .. .|    |.||| . ||||. ..|.  ...|.   | .    ||.|..    . ..|.. | . ...  . . .| . .  .    
YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks...keqygeifveiveekqyanlkirtfkltkkival

------EDSSTLKLKYIQYQEMLLKQCFPRA-DKFIKFIQGCLVEAESC--HRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQ
      ..  |  .| .|..|  |.. .|     .|....   .  |    .  . |....     . .|.. ..  .|. ..||  .|. . .     .
teqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrs

CPGLIVNLQFYAYCYDCLLEY
 |.|. | . | |.|| |||.
RpqLvenveeYkyiYdvllea

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1362-1566 8.8e-15 49.3 In-house 74-276 (315) alignment
Range on Protein: 1362-1566
Range on HMM: 74-276/315.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINL---SPADI-TTYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDS
 . . |. .. . . .| |  | | . . |||...|.. | |. .   .  |      | |   .|   .|| . |..   . .|.  .| . . . |.|
yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad.svefGsikvellsleadtdgvarklvtrksees

STLKlkYIQYQEMLLKQCFPRADKFIKFIQGclVEAEsCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
 |.     |..|   |    ..  ..|.|.   | |.  .. ....|.|     |  |.. ..  .....|..| .|...  .    . | |.   . ||
rtvt..qfqftewPdkGvdkqtssllklike..vkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

YCYDCLLEY
. || .||.
fiydavled

0041856 (Phosphotyrosine protein) phosphatases II 1362-1566 1.3e-11 39.9 In-house 21-170 (182) alignment
Range on Protein: 1362-1566
Range on HMM: 21-170/182.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSpaditTYSYIPpdvgdrqlkfgpltvsvgrkqfntgfstrdisifneedsSTLK
. . ....|.. .. ||    |...| . |.|.. .. .|.|.||.      . | |                                       . |.
yInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp.......................................elle

LKYIQYQEM-LLKQCFPRADKFIKFIQGCLVeaeschrGNHPILIHDDGSNGPVGIFATLAYCLQRakkeRiIDLLQSANHHYLQCPGLIVNLQFYAYCY
   |||. .     . |  |....||. .|         ..|.|.|  .  |  | .. . .....    . ..| .  ..   . || ......| ...
rlgiqylylpwpDhgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflq

DCLLEY
..|||.
lallel

0049772 (Phosphotyrosine protein) phosphatases II 1362-1574 1.8e-06 23.4 In-house 74-287 (314) alignment
Range on Protein: 1362-1574
Range on HMM: 74-287/314.0
KFTSYYLDGYwtpNLFIKSPSPTKETEELF----------WRLIV-QNECTHIINLSPADIT----------------------Tysyippdvgdrqlkf
 ... |.||.   . || .  |...| . |          ||... .   ...|  |  ...                      .               
yinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............

gpltvsvgrkqfntgfstrdiSIFNEEDSSTLKlkyiqyQEMLLKQCFPR--------------------ADKFIKFIQGClveaeschRGNHPILIHDD
                     .. ...|  .||      .|.  .. |.|                     |.|..||. .        . ..|.|.|  
.....................neptaadlellk......eelydpelferlgikylripvpDgsaplledfdeflefieea........dkggpvlvHCk

GSNGPVGIFATLAYCLQR--AKKERIIDLLQSANHhYLQCPGLIVNLQFYAYCYDCLLEYSDKLLKEE
.  |  | |...||.. .     | ... ...... .   ||.| .|. | .....|||| ..|.|. 
aGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkkfy

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1362-1574 2.8e-06 21.0 In-house 75-241 (392) alignment
Range on Protein: 1362-1574
Range on HMM: 75-241/392.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA---DittysyippdvgdrqlkfgpltvsvgrkqfntgfstrdisifNEEDSS
 . . |.... . . .| | .|   . . |||.. |.. | |. ..     |                                          . .|  
ylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................kgddar

TLklKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAY
|      .. |   |.   ..  ..|||.   |.|.   .  ||..||     | .|.  ..   . .||| |..|...       . | ..   . ||.
tv..aqfhftewPdkdvpkhtssllkfike..vkadfG.qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyaf

CYDCLLEysDKLLKEE
 | ..||  | | .. 
iygavle..dllwrnt

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1363-1566 9.6e-16 51.9 In-house 74-275 (515) alignment
Range on Protein: 1363-1566
Range on HMM: 74-275/515.0
FTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIIN---LSPADIT-TYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS
| . |. .. . . .| |  | | . . ||||..|.. | |.    |.  |      | |   ||  .||| . |..   .  ||   | . .  ..|| 
fnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd.svkfGsikvelvsleactggikrkltvlkgddsr

TLKlkYIQYQEMLLKQCFPRADKFIKFIQGclVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAY
|.     ...|   |   ...  ..|.|.   | |.   . .||..||     |  |.. ..  .. .||. |..|...  .    . | |.   . ||.
tvt..qfhfteWPdkGvpkhtssllklike..vkadhg.qythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

CYDCLLEY
 |. .||.
iygavled

subfamily_PTPN9_pd Subfamily PTPN9 1363-1569 9.7e-13 42.8 In-house 73-292 (297) alignment
Range on Protein: 1363-1569
Range on HMM: 73-292/297.0
FTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS
  . ..|||  .. ||    | |.| . |||.. ..|.  |.          .    | |.. .. . .|| |.||.   . .  . .| . | | ... 
inanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees.saefgdlsvsnveveeeedykvrvleiknvktee

TLKLKYIQYQEMLLKQCFPRADKFIKF------IQGCLVEA----ESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPG
. |. . |.           | .....       |...|..    .  |  . ||..|     |  | |.|| .||.| ...  .|. .. ..   |   
srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqraf

LIVNLQFYAYCYDCLLEYSDK
 |   . |..|| ..|||. .
siqtpeqyefcylavleyale

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1364-1568 2.1e-18 61.5 In-house 80-284 (319) alignment
Range on Protein: 1364-1568
Range on HMM: 80-284/319.0
TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVGD-RQLKFGPLTVSVGRKQFNTGFSTRDISIfNEEDSS--TL
 . ..|||   . ||   .| ..| | |||.. ..|.  .. |.         .     .    ..| |.| .  ..   ..  |.... |.  |   | 
nasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetR

KLKYIQYQEMLLKQCFPRADKFIKFIQGcLVEAEScHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCY
..|  ||.|   ..   .|   .....  . .. . .  . || .|     |  | | .|   |.| |.| ..|. . ...  .| . .. . . | ..|
evkhfqyteWpdhdvPekatslldllkr.irksre.ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiy

DCLLEYSD
. |||. .
ealleave

subfamily_PTPRB_pd Subfamily PTPRB 1364-1568 2.7e-13 44.6 In-house 83-286 (293) alignment
Range on Protein: 1364-1568
Range on HMM: 83-286/293.0
TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPDvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDssT
 . |..||..|. || .  |  || . |||.. ..... |. |        .    | | |  ...  .| ..|..  ..  . . .|...| .|..  .
nanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad..eepvlyGdikvtlvaeeeledwvirelkiekeke..e

LKLKYIQYQEMLLKQCFPRADKFIKFIQGCLvEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYC
 |..  ...         .......|..    || . .  ..||..|     |  |.| .|   ||. ..| ..|..    .   .   |. . . | . 
rkvrqyhftsWpdhgvPektktlldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi

YDCLLEYSD
..|.|..  
hqcvldllr

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1364-1570 1.1e-09 32.8 In-house 61-271 (274) alignment
Range on Protein: 1364-1570
Range on HMM: 61-271/274.0
TSYYLDGYW-TPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS---PADI-TTYSYIPPDVGD-RQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDs
 . |. ||  . . ..    |  .| . |||.| |.|.. |. |     |.      | | . .   . ..| . . |  .  . ..| | ... . |. 
nanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.

sTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
 . ..|.. | .   ..   .|........    ..|. .    |...|     |  |.| .   .... ..| ..|.|.   .  |.  |.. . . | 
.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqye

YCYDCLLEYSDKL
. .  | .|  .|
lihralclylkrl

0046845 (Phosphotyrosine protein) phosphatases II 1365-1570 6.3e-28 93.4 In-house 62-277 (284) alignment
Range on Protein: 1365-1570
Range on HMM: 62-277/284.0
SYYLDGY-----WTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEE
  |.|||     .... ||    |...| | |||.. ......|. | . .    .  . | |..  .  |..|..|| . ... . .. .| ... |..
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlg

-DSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAEScHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKER---IIDLLQSANHHYLQCPGLIV
 .. ........| .    .. | .. ...|.. .    |. . |..||..|. .  |  | |..| ..|.. .||.    .|.|.  ..   | || . 
ytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

NLQFYAYCYDCLLEYSDKL
.|. | ..|..||||  ..
tleqyrfvyealleylklk

Y_phosphatase Protein-tyrosine phosphatase 1365-1565 9.6e-23 76.2 Pfam-A 32-235 (235) alignment
Range on Protein: 1365-1565
Range on HMM: 32-235/235.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVGDrQLKFGPLTVSVG--RKQFNTGFSTRDISIFNEEDSS
  |..||.... || .  |.|.| | |||...|.... |. |   .     ..  | | . .. .|..| ..| .    |. .... .|.... .....|
AnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygdikvelkekekedekeytlrklelkkkkees

-TLKLKYIQYQEMLlKQCFP-RADKFIKFIQGCLVEAescHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFY
 . ..| ..|..   ... |  .......|. .  .    .  ..|...|     |  |.|..| ..|.....|. .|.||  ..   | ||.. .|. |
ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY

AYCYDCLLE
...|...||
iflykaile

Y_phosphatase Protein-tyrosine phosphatase 1365-1565 9.6e-23 76.2 In-house 32-235 (235) alignment
Range on Protein: 1365-1565
Range on HMM: 32-235/235.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVGDrQLKFGPLTVSVG--RKQFNTGFSTRDISIFNEEDSS
  |..||.... || .  |.|.| | |||...|.... |. |   .     ..  | | . .. .|..| ..| .    |. .... .|.... .....|
AnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygdikvelkekekedekeytlrklelkkkkees

-TLKLKYIQYQEMLlKQCFP-RADKFIKFIQGCLVEAescHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFY
 . ..| ..|..   ... |  .......|. .  .    .  ..|...|     |  |.|..| ..|.....|. .|.||  ..   | ||.. .|. |
ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY

AYCYDCLLE
...|...||
iflykaile

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1365-1570 8.5e-19 62.5 In-house 81-286 (290) alignment
Range on Protein: 1365-1570
Range on HMM: 81-286/290.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPDvgDRQLkFGPLTVSVGRKQFNTGFSTRDISIFNEEDSsTL
  |..||   . .|   .|...|   ||.||.|...| |. |         . . | |    | .  .|. .. .   .  ... .| ... |.. .   
AcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka.ygefsikllneetlneyierklevknknsa.ga

KLKYIQYQ--EMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAY
| . .|||   .  .   .     .  |.   ..    .|||..|..|  .. |  ..| ..|  ....|.|  ||..|  ..   | ||..   | | .
kqsvtqyqitnwdstgkvtnpqtillviee..myktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg

CYDCLLEYSDKL
 .. .|.| |..
ifqivltyldsf

subfamily_Ptp69D_pd Subfamily Ptp69D 1365-1570 3.3e-16 54.3 In-house 81-289 (307) alignment
Range on Protein: 1365-1570
Range on HMM: 81-289/307.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTY----SYIPPDvgdRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS--
. .. ||   . || .  |  .| . |||.| . | | |. ||  . ..      | | .    . ..| . | . .... . .  |.... . ...|  
asfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesge

-TLKLKYIQYQEMLLK-QCFPR-ADKFIKFIQGClVEAESCHrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQF
   . | .||. .  |    |. |   .|.|.    | .. .  . ||..|     |  ||| .|.  ||. |.|  .|. .   .   | . |. .|. 
vedsrkvvqyhytgWkDskvPevargllklieqv.relykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleq

YAYCYDCLLEYSDKL
| ..|  ||.||.. 
Yvflyralldyssyg

subfamily_PTPRA_pd Subfamily PTPRA 1365-1572 1.5e-15 51.9 In-house 91-303 (330) alignment
Range on Protein: 1365-1572
Range on HMM: 91-303/330.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPpDVGdrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTL
. ..|||   . || .  | .|| | |||.| . . . |. |.      .   . | | | |   . .| ..|.|  ..    .. |.. . .  |..  
asfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.deG..lvtyGnirvevedetvlvdytvrkflvqqlpdatre

KLK-YIQ-YQ-EMLLKQCFPRAD-KFIKFIQGclVEAESCHRGNhPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFY
| .  .. .  .   .   |      .|...   |..     .. || .|     |  | | .|   |.| | ||..|. .  ..  || | ..  .. |
kksrlvrqfhftswPdvGvPfepiGmlkllkk..vkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

AYCYDCLLEY---SDKLLK
 ..|  ||||    |  |.
efiykvlleyylygdteld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1365-1567 6.2e-14 46.7 In-house 80-279 (288) alignment
Range on Protein: 1365-1567
Range on HMM: 80-279/288.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPdvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFneEDSSTL
. |.||.   . .| . .|  .| . ||.|. .|. . |. |.      . .   | |   .|.. ..| .|| .  ..  . | .| . .    . . |
asyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd..adkpknyGsvtvtlveskeledfvlrkllle..kkktel

KLKYIQYQEMLLKQcFPR-ADKFIKFIQGCLVEAESChrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYC
...  ||.    ..  |. .  ......   |  ..      ||..|     |  |.| .|   ... ..|  ||..   ..   | . |. .|. | ..
eitqyqylaWpdhg.vPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

YDCLLEYS
|..||.  
yevllsli

subfamily_PTPRG_pd Subfamily PTPRG 1365-1566 1.5e-13 44.8 In-house 81-286 (563) alignment
Range on Protein: 1365-1566
Range on HMM: 81-286/563.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFN----EED
  |.|||   . || .  | |.| . |||.| ... . |. ..            | |    |  ...| |.|   ...  .  ..| ..| |    ...
AnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...desetygalqvtlieeevlalytvrtlviknlklkkkk

SSTLKLKYIQYQEML-LKQCFPRADKF-IKFIQGClveAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQ
.   ... .||.      .. |    . ..|..     . . ..   ||..|..   |  |..  |   |.. ..| ...... . |  .| . |. .  
qcdteklvrqyhytkWPdhgvPehslpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteE

FYAYCYDCLLEY
 | . .| ||| 
qYiflhdallea

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1365-1566 2.5e-11 37.9 In-house 70-276 (287) alignment
Range on Protein: 1365-1566
Range on HMM: 70-276/287.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINL----SPADITTYSYIPPDvgDRQLKFGPLTVSV-GRKQFNTGFSTRDISIFNEEDSST
. |. .|   . || . .|   |   |||...... . .| .      |   .| | |    .. .. |  .| .  ... .  ...| . . . |   .
anyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrvGGysvvlldydikePeygvralrlidletrea

LKLKYIQYQEMLLKQCFPRADKFIKFIQGC--LVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
  .| ... ..  |   | |  .|.|.  .   .|..    .  |...|||   |  ||. ..  ...| ..   .|  .   .   .  .|.     . 
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlr

YCYDCLLEY
. |. |  |
llyealvty

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1365-1571 1.4e-10 35.7 In-house 74-280 (281) alignment
Range on Protein: 1365-1571
Range on HMM: 74-280/281.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIIN----LSPADITTYSYIPpDvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIfNEEDSSTL
. ...||  .. .| . .|  .. . ||....... . |.     .    .  . | | | .. .||.| .||.  ... .. . .| ... ..|.. | 
anfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.d.dnselkygdvtvkstaeeekatyierkfkl.eresgetr

KLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKE-RIIDLLQSANHHYLQCPGLIVNLQFYAYC
... ..|.    .     . ....| .   |.  . .. ..|..||     |  | . .|   ......| . .|. .  ..   .   ..  .  |.. 
eveqlaytaWPdhGvPattkellefrke..vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefv

YDCLLEYSDKLL
|  .|.. || |
ykavldaldkel

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1365-1566 2.2e-09 31.4 In-house 75-292 (301) alignment
Range on Protein: 1365-1566
Range on HMM: 75-292/301.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADIT----TYSYIpPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS--
. |.|||   . || . .| |.|   |||||.|.  ..|. .   . .    .. |  |.   .. .|||.|| .  .|    |  |....  .. |.  
asyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw.pnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnng

----TLKLK-------YIQYQEMLL--KQCFPRADKFIKFIQGCLVEAESChrGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQ
    ..| |        .|.|          .     .. |.  .    .   |  |...|   . .  |.. ..   |  .| | ..|. |  .    .
yierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki..gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrs

CPGLIVNLQFYAYCYDCLLEY
 || .  |. |   || . .|
kpgaVtTLeqytsiydvidmy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1365-1564 2.6e-09 30.9 In-house 226-435 (440) alignment
Range on Protein: 1365-1564
Range on HMM: 226-435/440.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYS-YIPpdVGDRQLKFGPLTVSV-GRKQFNtGFSTRDISIFNEEDSSTLKL
   ..||   | || .  |   |   ||||. . . . || |   .  | | | |  |  | . |||.||   | ...|     | . .   |.   .. 
qqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywp..vntrsvtfgpftvghkgsenmn.rvkvrtlelkykeevheirq

-------KYIQYQEML-LKQCFPRADKFIKFIQGCLVE--AESCHRGN-HPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIV
        .|| . .   .||.    ... ... | ..  .|    |.  |||.|        |.| |.  ||.. ...  ||..|      |  | .. 
fevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvp

NLQFYAYCYDCLL
 |  |  ||  | 
tltdyllcykllt

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1365-1564 5.8e-09 30.5 In-house 35-236 (237) alignment
Range on Protein: 1365-1564
Range on HMM: 35-236/237.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPdvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTL
.|  .   ||. .| .  | . . . ||... |. |. |. |.      ..  . | |    |.   .| ||||. .|.  . .. | . ....     .
tylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps..tdqpaaygvltvslkkkeefsdytvrslllskrltlkev

KLKYiQYQE-MLLKQCFPRAD-KFIKFIQGcLVEaESCH-RGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
.| . |||     ..  |.    ...| .  ... .| |     | .||     | .|||  .   |..||.....|. .       . | .|   . | 
rlih.qyqftswpdrgvpqqtaallrfrkn.iin.rsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyv

YCYDCLL
. .. .|
fihqtil

subfamily_PTPN12_pd Subfamily PTPN12 1365-1572 3.4e-07 24.4 In-house 73-282 (290) alignment
Range on Protein: 1365-1572
Range on HMM: 73-282/290.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS---P-ADITTYSYIpPDVGDRQLKFGPLTVSVGRKQ-FNTGFSTRDISIFNEEDSSt
. .. |   .  .| . .|  .| . |||.| . . . .. .      . .    |  |. |...|.||...|.. ... .. .|  | . . ....|  
anfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW.peegeeelefgefevtleeekavdddflirtLkveaqkesr.

lKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERI---IDLLQSANHHYLQCPGLIVNLQFY
 |.. ..|..   ...  .|.. ...|.      |   . ..|...|     |  |.  .. |  .  |.|.|   .|. .   .   | . |.   . |
.kvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

AYCYDCLLEYSDKLLK
 . | ...|.  | |.
elvykavaelvqkele

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1366-1566 2.3e-14 48.6 In-house 59-254 (284) alignment
Range on Protein: 1366-1566
Range on HMM: 59-254/284.0
YYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSpADiTTYSYIPPDVGDrqlKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTlKLKYI
 .. ||  .. .| .  | ..| . |||.| . .|. |. |.  |     | | ..     | .   |.|   .    .  ||| . ..      . |  
sfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kd.kcsqywplkivi...keerfkvkvdsveeseeyvvrdielsedgkekd.irkir

QYQEML-LKQCFPRAD-KFIKFIQGcLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCL
|.  .   ..  |    .......  .   .| ......|..|     |  |.. .|   |.| |.|. .|. .  .    | . |. .|  | ..|  |
qfhflgwpdvgvpdypsdlmrlvkk.vrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

LEY
|| 
lee

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1366-1565 3.7e-14 47.7 In-house 95-289 (319) alignment
Range on Protein: 1366-1565
Range on HMM: 95-289/319.0
YYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSpADiTTYSYIPPDVGDrqlKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSsTLKLKYI
 ...||  .. .| .  | ..| . |||.| . .|. |. |.  |     | | ..     | .   |.|   .    .  ||| . ..    . . |  
sfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kd.kcsqywplkivi...keerfkvkvdsveetaeyvvrdielsedgke.kdirkit

QYQEMLL-KQCFPraDKFIKFIqgCLVE----AESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCY
|.  .   ..  |  |  ....  .||.     .|  .....|..|     |  |.. .|   |.| |.|. .|. .  .    | . |. .|  | ..|
qfhflGwpdvGvp..dypsdlm..rlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiy

DCLLE
  |||
salle

0036282 (Phosphotyrosine protein) phosphatases II 1366-1561 2.7e-12 42.2 In-house 8-164 (174) alignment
Range on Protein: 1366-1561
Range on HMM: 8-164/174.0
YYLDGYWTPNLFIKSPSPTKeteelFWRLIVQNECTHIINLSPADITT----YSYIPPdvgdrqlkfgpltvsvgrkqfntgfstrdisifneeDSSTLK
..||... .. .| .  |..     ||... .. .|....| .         . | |                                     ... |.
spldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lredle

LKYIQYQEMLLKQCFP----RADKFIKFIQGCLVEaeschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKkERIIDLLQSANHHYLQCPGLIVNLQFYA
   |||. .      .      ..|.||.. .| |      ...|.|.|  .  |  |... . ..|.. . |. .| |.      ||.|| . . ..| 
rlgiqylylpwpDhgvpdlsillefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

YCYD
..|.
flyy

0043147 (Phosphotyrosine protein) phosphatases II 1366-1560 9e-10 34.0 In-house 11-154 (172) alignment
Range on Protein: 1366-1560
Range on HMM: 11-154/172.0
YYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAdittysyippdvgdrqlkfgpltvsvgrkqfntgfstrdisifnEEDSSTLKLKYI
.|||.|. |. ||    |. .| . |||.. .. .|||.|| .                                             . | . |.  .|
syldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpellerlgi

QYQEMLLKQ----CFPRADKFIKFIQGCLveaesCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANhhylqcPGLIVNLQFYAYCY
||. .         .   ..|..||.  |     . . ..|.|.|  .  |  | .. . ..|.. . | ...|....       || . | ..| ..|
qylylpwpDhgvpllellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvrekR......pgavqnpsqyrfly

0040438 (Phosphotyrosine protein) phosphatases II 1367-1583 5.7e-30 100.1 In-house 78-292 (317) alignment
Range on Protein: 1367-1583
Range on HMM: 78-292/317.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKL
| ||.. .. ||   .|...| | |||.. .. .|.|..| . .    .. . | |    .  |..|..|| .   . . |.  | . . . .|| ....
yvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtv

KYIQYQEMLLKQCFPRADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDC
. ..|       . |  | ...|.. .    |   ....|.|.|  .  |  | |... ..|.. .||. .|. .  ..   |.|| . ....| ..||.
thfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

LLEYSDKLLKEESLPPIYENI
||||  . |. |.... .  .
lleylkrkltlepaselklkl

DSPc_SM00195 1367-1566 1.5e-21 72.2 In-house 61-261 (263) alignment
Range on Protein: 1367-1566
Range on HMM: 61-261/263.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVgDRQLKFGPLTVSVGRKQFNT-GFSTRDISIFNEEDSSTLK
|..|.. .. .|    |...| | |||........ |. |.  .     . ..| | .  ... .|| ..| . ...     . .|.... .|... | |
yikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrk

LKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESChrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYD
.. .||..   ...   ......... .  . ..    ..||..| .   |  |.|.|. ..|.. ..|  .|. .  ..   | ||.. .|..|...|.
vtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiye

CLLEY
..|||
ailey

PTPc_SM00194 1367-1566 1.5e-21 72.2 In-house 61-261 (263) alignment
Range on Protein: 1367-1566
Range on HMM: 61-261/263.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVgDRQLKFGPLTVSVGRKQFNT-GFSTRDISIFNEEDSSTLK
|..|.. .. .|    |...| | |||........ |. |.  .     . ..| | .  ... .|| ..| . ...     . .|.... .|... | |
yikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrk

LKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESChrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYD
.. .||..   ...   ......... .  . ..    ..||..| .   |  |.|.|. ..|.. ..|  .|. .  ..   | ||.. .|..|...|.
vtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiye

CLLEY
..|||
ailey

subfamily_PTPRD_pd Subfamily PTPRD 1367-1569 2.8e-20 67.5 In-house 83-283 (564) alignment
Range on Protein: 1367-1569
Range on HMM: 83-283/564.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvgDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKL
..||| ... .| .  |..|| | |||.. ..... |. |.           .| | .  . . ..| |||..  ..  . .. |.... ....|.. . 
fidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g.tetygeltVtleeeeeladyeirtfklkkkkssesreV

KYIQYQEMLLKQCFPRADKFIKFIQGclVEAEScHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDC
.  .. .   .     | .....|.   |.| . .....||..|     |  |.| .. ..|.|.|.|. .|. |  ..   | . .. . . |..... 
rqFhFtsWPdhgvpesatslLdlirk..vraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFihea

LLEYSDK
.||. ..
ilealac

0045098 (Phosphotyrosine protein) phosphatases II 1367-1567 1.2e-19 66.2 In-house 58-272 (278) alignment
Range on Protein: 1367-1567
Range on HMM: 58-272/278.0
YLDGYwtPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE----EDSS
|.|||  |. ||    |...| . |||.. .. .|.|..| .      .  . | |.   .  | .|..|| .   . .  . .|.. . |     ||  
yidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredle

TLKLKYIQYQEMLLKQCFPRA-----DKFIKFIQGCLVE-------AESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAkkERIIDLLQSANHHYLQC
........|  .    . .       .....||. .| .         ... ...|.|.|     |  | .. . ..|..   |. .|||.  ..   | 
srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqR

PG-LIVNLQFYAYCYDCLLEYS
||  . ||..| ..|..|||. 
pglavqnleqyrflyefllell

0051429 (Phosphotyrosine protein) phosphatases II 1367-1571 3.6e-15 51.8 In-house 11-229 (272) alignment
Range on Protein: 1367-1571
Range on HMM: 11-229/272.0
YLDGYWT---PNLFIKSPSPTKETEELFWRLiVQNECTHIINLSPAD----ITTYSYIP---------PDVGDRQLKFGPLTVSVGRKQFNTGFSTRDIS
...||.    |.... |. |.. |.. ||||  .. ...|..| . .      .. |.|         .| .. .  .| |.| .  ... . .  | . 
dvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrell

IFNE-EDSSTLKLKYIQYQEMLLKQCFPRAdkFIKFIQGCLVeaeschrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIID--------LLQSANH
. ..   . ....  ..|. ..     . |  ...... .|         ..|.|.|  .  .  |... | ..|..  .| |.|        |..  ..
ltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee

HYLQCPGLIVNLQFYAYCYDCLLEYSDKLL
   | || . . ..|...|..|||. ..||
lraqrpgavqteeqylflyeallellrsll

0049260 (Phosphotyrosine protein) phosphatases II 1367-1561 1.7e-08 29.8 In-house 1-144 (152) alignment
Range on Protein: 1367-1561
Range on HMM: 1-144/152.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVgdrqlkfgpltvsvgrkqfntgfstrdisifneedsstlklkyiQ
..|||. |. ||    |. .| . |||.. .. .|.|..|   .  .. . .                                               |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

-----YQEMLLKQCFPRADKFIKFIQGClveaesCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANhhylqcPGLIVNLQFYAYCYD
        .   .     . ...||. .      ... ..|.|.|  .  |  | .. . ..|.. . | ...|.....      || . | ... ..|.
ylhlpwpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylmllgvsleeavalvrekR......pgavpnpgqlrflye





subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1367-1571 6.1e-08 27.0 In-house 55-268 (270) alignment
Range on Protein: 1367-1571
Range on HMM: 55-268/270.0
YLDGYW-TPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVGD-RQLKFGPLTVSVGRKQFNTGFSTRDISIFneEDSSTL
|. |.   .. .| . .|.. | . |||.|.... | |. ...           | |.....  .|..| ..| .  .. ..|. .. . .   |.... 
yvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeer

KLKYIQYQEMLLKQCF------PRADKFIKFIQGCLVEAESCHRGNhPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQ
.|   .|..   .          ..|. .| ..      .. .... |.|.|.    |  |.. .| ....  .... .|.|.  ..   . . |.   .
rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe

FYAYCYDCLLEYSDKLL
 |.. |  ..|| ....
qyeflykavveyaerra

0051082 (Phosphotyrosine protein) phosphatases II 1369-1564 5.5e-06 21.6 In-house 7-150 (151) alignment
Range on Protein: 1369-1564
Range on HMM: 7-150/151.0
DGYWTPNLFIKSPSPTKeteeLFWRLIVQNECTHIINLSPADITTYSYIP-PDVGdrqlkfgpltvsvgrkqfntgfstrdisifneedsstLKLKYIQY
.  .  . .. |  |.      |..|. .. ...|.|| . . . | . . |. |                                     .....|..
nfsyvtgglyrsggpla....dflellkelgiktivnlrseeergycpeylpelg.....................................ievlhipi

QEML---LKQCFPRADKFIKFIQGclveaeschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHhylqcpGLIVNLQFYAYCYDCLL
  .    | ..|. . .|.....           .|.|.|.|  .  |  |... |  .|..   | ... ... ..      |..   | . ... .||
ldwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrp......gvvqpnqqflfqlfall





0037934 (Phosphotyrosine protein) phosphatases II 1371-1566 1.1e-18 63.1 In-house 43-241 (243) alignment
Range on Protein: 1371-1566
Range on HMM: 43-241/243.0
YwtPNlFIKSPSPTKETEEL----FWRLIVQNECTHIINLSPAD----ITTYSYIPpdvgDRQlKFGPLTVSVGRKQFNTGFSTRDISIFNEE-DSSTLK
.  |. .| .  |..|| |     |||.. .. .|.|..| . .    .  . | |    . .  .|..|| .   .   ..  | ... | . |  |. 
t..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gev.tygdftvtllseehlddytvrtlllenldlddltrl

LKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAES-----CHRGNHPILIHDDGSNGPVGIFATLAYCLQRAkkeRiIDLLQSANHHYLQCPG-LIVNLQF
   ..|  .   .. .  . ...|.. .    |.     .  ...|.|.|  .  |  | .... ..|..    . .||..  ..   | ||  . ....
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq

YAYCYDCLLEY
| ..|..|||.
yrflyeallel

0044763 (Phosphotyrosine protein) phosphatases II 1373-1565 2.6e-06 22.7 In-house 27-169 (178) alignment
Range on Protein: 1373-1565
Range on HMM: 27-169/178.0
TPNLFIKSPSPtketeELFWRLIVQNECTHIINLSPADITT----YSYIPPDVGdrqlkfgpltvsvgrkqfntgfstrdisifneedsstLKLKYIQYQ
.|.|.. |  |     . ...|. .. .|||.||.. .       . | | . |                                     .. ..| . 
lpglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.....................................iqylhipip

EMLLKQCFPRADKFIKFIQGCLveaescHRGNHPILIHDDGSNGPVGIFATLAYCLQRakkeRIiDLLQSANHHYLQCPgLIVNLQFYAYCYDCLLE
 .   . .   ..|..||. .|      .. ..|.|.|     |  | .. . .....    .. .| .  ..   . |  . |  .. ..|.. |.
Dhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

subfamily_PTPN3_pd Subfamily PTPN3 1375-1568 7.3e-12 39.8 In-house 84-276 (280) alignment
Range on Protein: 1375-1568
Range on HMM: 84-276/280.0
NLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPdVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEM
| .| .  | ..| . ||... ..... |. |        .  . | |   .| .|..| ..| . ... .. . .|.. . ..| .   |.  .|| . 
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.ted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaW

LLKQCFPRADKFIKFIQGCLvEAEscHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSD
  ..    ...|..|..    ..   .  ..|...|  .  |  |.. .|  .|.   ... .  |.   .   |   |. . . | .  ...|. ..
pdhgvPddsadflefvervr.klr..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

subfamily_PTPN6_pd Subfamily PTPN6 1375-1569 2.3e-06 21.8 In-house 98-299 (306) alignment
Range on Protein: 1375-1569
Range on HMM: 98-299/306.0
NLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPDvGDRQLkFGPLTVSVGRKQFNTGFSTRDISIFN-EEDSSTLKLKYIQYQE
. .| .    ..| . |||...|.... |. .           . | |    ...  .| ..|.  ... .. .  |..|. . ...... ..   ....
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde.eekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

MLLKQCFPRADKFIKFIQGCLVEAESCH-RGNHPILIHDDGSNGPVGIFATLAYCLQRAKK---ERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLE
   . .    . ...|..    ..|... . . ||..|     |  | |  .   |.  .|   .  ||. .. . .  |  ||.   | | . |  . .
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

YSDK
| ..
yiet

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1376-1565 2.8e-15 50.9 In-house 76-264 (283) alignment
Range on Protein: 1376-1565
Range on HMM: 76-264/283.0
LFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPpDVGdrQLKFGPLTVSVGRKQFNTGFSTRDISIFNE-EDSSTLKLKYIQYQEM
 .| . || ..|   ||... ... | |. |..     .|    | |   |    ..|..||.. .   .  |. . . . ..    ||| | . |... 
kyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP.krG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW

LLKQCFPRADKFIKFiqgCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLE
|  .  .  . ..||    .| .   .  . ||..|     |  ..| ...  .. |. | ..|. .  .    | .... .|. |   ..  ||
leygeqaiinslvkf...nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1376-1566 4.2e-11 37.5 In-house 93-283 (297) alignment
Range on Protein: 1376-1566
Range on HMM: 93-283/297.0
LFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQC
 .| .  | |.| . ||....... . |. |.  . .. .       .   .|| ..| .   .  .||. |.... ...  ..  .|  |. |   |. 
rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkav

fPRADKfIKFIQGCLVEAESCHRGN--HPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
 .| |. .. ..  . | .  . .|   |.|.|     |  |.. |.  .. .||.|  .|...  ..   . | |.   . |.. |  .||.
.erkds.assllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

subfamily_PTPN23_pd Subfamily PTPN23 1377-1571 1.2e-10 35.7 In-house 85-284 (288) alignment
Range on Protein: 1377-1571
Range on HMM: 85-284/288.0
FIKSPSPTKETEELFWRLIVQNECTHIINLSPADITT----YSYIPPDVGDRQlKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMlL
|| . .| ..|   ||......    |. |   . .      .| | | |. . |||.|.|.. ...    .. |....  .. . . .....|...   
fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv.kfgdlsvtlksvretethvervlkletldadavksvshlqltsW.p

KQCFPR-ADKFIKFIQGCLV-EAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRA-KKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDK
.   |   .....|..       .  .. . |...|     |  |.|| .   ..   |.. ..|..|  ..   |    . . . .  .|.  ||.  .
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

LL
 |
vl

subfamily_PTPN14_pd Subfamily PTPN14 1377-1566 8.1e-07 23.3 In-house 95-295 (300) alignment
Range on Protein: 1377-1566
Range on HMM: 95-295/300.0
FIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPD-VGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEML
.| . .| . | . ||... ... . |. |          ...|.| .    ....||   |.   ..  . . |. . .     .   .. ..||..  
yivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

LKQCFPRADKFIKFIQGC---LVEAES---CHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLE
 ... .  ..|.....       ...|    .  . |.|.|     |  |.  .    ..  .... ||. .. ..   |   |. .|  | . |. |..
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

Y
|
y

subfamily_PTPN13_pd Subfamily PTPN13 1380-1566 8.4e-07 23.5 In-house 82-268 (273) alignment
Range on Protein: 1380-1566
Range on HMM: 82-268/273.0
SPSPTKETEELFWRLIVQNECTHIINL----SPADITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQC
.  |  || . ||... . ... |. .        .    | |   ...    . |.|.. . |   ||. |.. . . | . . ..  ... .    . 
cqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgv

FPRADKFIKFIQgclvEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
   |.....|..    |  . .. . ||..|     |  |.. |.   |.  .... .|. .  ..   |  |..   . | ..|  .|| 
Pssaaellqfva....evrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1425-1584 5.5e-102 336.4 In-house 278-439 (439) alignment
Range on Protein: 1425-1584
Range on HMM: 278-439/439.0
QLKFGPLTVSVGR--KQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAY
....| ..|....  |.||.||||||||||||||||.|||||||||||||||||||.|||||||||||||.|||||||||||||||||||||||||||||
divyGdiavtidefkkefnagfstrdisifneedssllklkyiqyqemllkqcfprvdkfikfiqgclveveschrgnhpilihddgsngpvgifatlay

CLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDKLLKEESLPPIYENIA
|||||||||||||||||||||||.|||||||||||||||||||||||||||||||.||||||
clqrakkeriidllqsanhhylqspglivnlqfyaycydclleysdkllkeeslpsiyenia

PTPc_DSPc_SM00012 1462-1565 9.1e-07 24.4 In-house 5-105 (105) alignment
Range on Protein: 1462-1565
Range on HMM: 5-105/105.0
LKYIQYQEMllkqCFPR-ADKFIKFIQGCLVEAESCHRgNHPILIHDDGSNGPVGIFATLAYCLQRAKKE-RIIDLLQSANHHYLQCPGLIVNLQFYAYC
..| .....    . |. .|....... .  . . . . ..|...|.    |  |.|..|...||. .|| . .|..|  ..   | ||.. ... | ..
yhytgwpdh....gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDCLLE
|..|||
yralle