Gene PTPRD-40 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP096_AA protein Get Run
AqueP096_AA_0-173 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-176 2.8e-85 281.2 In-house 98-287 (305) alignment 
Range on Protein: 1-176
Range on HMM: 98-287/305.0
MENTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTGSKTH----GEFSVEVNNERSANGYTERNLKLSF---DKETRSVLQFQVTDWPQDGVVRKA
..|||.|||...|..||||||||.    |..|.|.|||..|||.    ||||||...|..|..|.||.||.|.   |||.|.|||.|.||||..||...|
lkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfa

GTILQVINDVRNRQKRG---PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTTN
...|..|..|...||..   |..||||..|.|.||...|.||||.. ||.|||||.|.|..|......|.|..||....|..|.......
tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-175 6.5e-76 249.9 In-house 94-296 (301) alignment 
Range on Protein: 1-175
Range on HMM: 94-296/301.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTG----SKTHGEFSVEVNNER-----------------SANGYTERNLKLSFDKETRSVLQF
|..|..|||......|...|||... ...    |.|||      |.. |.|.|...||                  | |||.||..| . ||....|||.
mkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlql

QVTDWPQDGVVRKAGTILQVINDVRNRQK---RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
||||||||||||   |.||||.||  ||.    ||||||||||||||||||||||.||||  |||||||||||.||||||||||| ||| ||||.|| |.
qvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

QTT
|  
qln
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-175 8.2e-56 184.0 In-house 100-286 (290) alignment 
Range on Protein: 1-175
Range on HMM: 100-286/290.0
MENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGS--KTHGEFSVEVNNERSANGYTERNLKLSFDKE---TRSVLQFQVTDWPQDGVVRKAGT
..||..||||.... ||. ||||.     ... |.|||. |  |. ||||....||.. |.|.||.|..  ...   ..|| |.|.| |...| | .  |
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

ILQVINDVRN-RQK--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
||.||. . . . |  ....||||||||.||.|.|.. .....| .|||.||||| |. |  ||| |.|..||  |..|.  |... 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-176 2.9e-54 179.0 In-house 95-282 (287) alignment 
Range on Protein: 1-176
Range on HMM: 95-282/287.0
MENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGSK--THGEFSVEVNNERSANGYTERNLKLSFDK---ETRSVLQFQVTDWPQDGVVRKAGT
| ||.|.|||.. | .|..|||||     ||. |||||. .|  . ||...|. ||   .||.||.|..  ..   ....| |.|.|.|.. | | .  |
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

ILQVIND-VRNRQKR--GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTTN
|| ||.. .....||  ...|||||||| ||...|.. .....| .|||.||||| |  |  |||.| | |||  |.||.  |... .
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
0050432 (Phosphotyrosine protein) phosphatases II 1-174 1.2e-52 174.6 In-house 117-301 (308) alignment 
Range on Protein: 1-174
Range on HMM: 117-301/308.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW-----TGSKTHGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRKA
..||| |||.|. ...|..||||.  ..     |.|||      ||...| |.|.. .| . ..|| |.|.|..  |.|.| | .|. |.|| .||  ..
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

GTILQVINDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
  .|. .. ||.... ||.|||||. |.|.|... . ..|||  ||| ||||.. |..|. .||.|.| |||  .|...  |...
eilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 1-172 3.6e-50 166.4 In-house 101-286 (288) alignment 
Range on Protein: 1-172
Range on HMM: 101-286/288.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW--TGSKTHGEFSVEVNNERSANGYTERNLKLS------FDKETRSVLQFQVTDWPQDGVVRK
..||| |||.|. ...|..||||.. ..     |.|||   ||.|.|...|.  .| . ..|| |.|...      .|.|.| | .|..|.|| .||   
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

AGTILQVINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
.  .|. ...||.   .. ||||||||. |.|.|... . ..|||  |||.|||... |..|. .||.|.| |||  .|...  |.
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 1-174 1.4e-49 164.4 In-house 86-276 (284) alignment 
Range on Protein: 1-174
Range on HMM: 86-276/284.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWT---GSKTHGEFSVEVNNERSANGYTERNLKLSF---DKETRSVLQFQVTDWPQDGVVRKAG
..||| |||.|. ...|..||||.. ..     |.|||    ...|.|.|.|.. .|   ..|| |.|.|..   ..|.| | .|..|.|| .||   . 
lpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspe

TILQVINDVRNRQK----RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEG---VVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
 .|. ...||. ..     ||.|||||. |.|.|... . ..||| .|||   .|||... | .|. .||.|.| |||  .|...  |...
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0036941 (Phosphotyrosine protein) phosphatases II 1-174 4.2e-49 162.8 In-house 87-279 (297) alignment 
Range on Protein: 1-174
Range on HMM: 87-279/297.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW----TGSKTHGEFSVEVNNERS--ANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRK
..||| |||.|. ...|..||||. ...     |.|||     .|.|.|.|.|.. .. .   ..|| |.|....  ..|.| | .|..|.|| .||   
lpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpes

AGTILQVINDVRNRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCI---KEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
. ..|. |. ||...    . |||.||||. |.|||... . ..|.|     ||| ||.... |..|. .||||.| |||  .|...  ....
paslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0039614 (Phosphotyrosine protein) phosphatases II 1-174 1.1e-48 161.7 In-house 110-291 (297) alignment 
Range on Protein: 1-174
Range on HMM: 110-291/297.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC---CYQYW--TGSkTHGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQV
...|| |||.|. ...|..||||.  ...   |.|||  .|. |.|.|.|.. ..   .||| |.|... ..|.| | .||.|.|| .||   . ..|..
lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef

INDVRNRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
.. ||...    | |||.||||. |.|.|...   ..|||. ||| |||... |..|. .||||.| .||  .||..  ....
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0047943 (Phosphotyrosine protein) phosphatases II 1-171 1.2e-48 161.3 In-house 86-271 (273) alignment 
Range on Protein: 1-171
Range on HMM: 86-271/273.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTG-----SKTHGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRKA
..||| |||.|. ...|..||||. ...     |.|||       |.|.|.|.|.. .| . ..|| |.|.|..  ..|.| | .|..|.|| .||    
lpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppsl

GTILQVINDVRNRQK----RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
  .|. |..||. ..     ||||||||. |.|.|... . ..|.| .||| |||... | .|. .||.|.| |||  .|...  |
esllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPRD_pd Subfamily PTPRD 1-176 1.4e-48 160.9 In-house 100-285 (564) alignment 
Range on Protein: 1-176
Range on HMM: 100-285/564.0
MENTVRDFWKMMVDYKVSTIVMLCGDE----DCCYQYWTGS--KTHGEFSVEVNNERSANGYTERNLKL--SFDKETRSVLQFQVTDWPQDGVVRKAGTI
...|..|||.|. ....||||||   |    . | .||  .  .|.||. |....|   . |. |..||  . ..|.| | ||. |.||. ||  .| ..
laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LQVINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTTN
|..|..||.   ...||.|||||  | |.|... ... ||.  .|..||..|. |..|. ..  | |.|||  |...|  ...  |
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
Y_phosphatase Protein-tyrosine phosphatase 1-168 1.9e-48 160.3 Pfam-A 51-233 (235) alignment 
Range on Protein: 1-168
Range on HMM: 51-233/235.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWT----GSKTHGEFSVEVN-NER-SANGYTERNLKLSFDKET---RSVLQFQVTDWPQDGVVR
...|. |||.|....||..||||. .|.     | |||     .|.|.|...||.  .|    ..|| |.|.|. .||    |.| |...|.||. || .
lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpe

KAGTILQVINDVRNRQ--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
..  .|..|..|....  |.||||||||. |.|.|......|.|||. .|. |||.|. |..|...||.|.. |||  .|..|
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1-168 1.9e-48 160.3 In-house 51-233 (235) alignment 
Range on Protein: 1-168
Range on HMM: 51-233/235.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWT----GSKTHGEFSVEVN-NER-SANGYTERNLKLSFDKET---RSVLQFQVTDWPQDGVVR
...|. |||.|....||..||||. .|.     | |||     .|.|.|...||.  .|    ..|| |.|.|. .||    |.| |...|.||. || .
lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpe

KAGTILQVINDVRNRQ--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
..  .|..|..|....  |.||||||||. |.|.|......|.|||. .|. |||.|. |..|...||.|.. |||  .|..|
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
DSPc_SM00195 1-172 2.7e-48 159.9 In-house 78-262 (263) alignment 
Range on Protein: 1-172
Range on HMM: 78-262/263.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTGS----KTHGEFSVEVNNERSAN-GYTERNLKLSFDK--ETRSVLQFQVTDWPQDGVVRKA
...||.|||.|... ||..||||. .|..    |..||  .    .|.|..||.. .. . .  .. |.|.|....  |||.| |.|...||. ||  ..
lpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdst

GTILQVINDVRNRQK--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
  .|.... |.....   ||.|||||. |.|.|......|.|... .|  ||.|.. | .| ..||.|.|.|||  ||..|  |.
ksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-172 2.7e-48 159.9 In-house 78-262 (263) alignment 
Range on Protein: 1-172
Range on HMM: 78-262/263.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTGS----KTHGEFSVEVNNERSAN-GYTERNLKLSFDK--ETRSVLQFQVTDWPQDGVVRKA
...||.|||.|... ||..||||. .|..    |..||  .    .|.|..||.. .. . .  .. |.|.|....  |||.| |.|...||. ||  ..
lpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdst

GTILQVINDVRNRQK--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
  .|.... |.....   ||.|||||. |.|.|......|.|... .|  ||.|.. | .| ..||.|.|.|||  ||..|  |.
ksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040438 (Phosphotyrosine protein) phosphatases II 1-174 4.8e-48 159.4 In-house 95-278 (317) alignment 
Range on Protein: 1-174
Range on HMM: 95-278/317.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW--TGSKTHGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRKAGTI
..||| |||.|. ...|..||||.  |..    |.|||   ...|.|.|.|.. .|   .|.| |.|...   |.|.| | .|. |.|| .||     ..
lpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

LQVINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
|. .. ||.   .. |||.||||. |.|.|... . ..|||. ||| |||... |..|. .||||.| |||  .||..  |...
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-176 2.5e-46 153.3 In-house 108-294 (298) alignment 
Range on Protein: 1-176
Range on HMM: 108-294/298.0
MENTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWTG--SKTHGEFSVEVNNERSANGYTERNLKLSFDK--ETRSVLQFQVTDWPQDGVVRKAGTI
...|| |||.|.......|||||   |.     . .||    ..|.||..|.. .. .   .. |.||.|  |  ..|.| |...| ||. || ..| ..
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsv

LQVINDVRNRQ-KRG--PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTTN
|.....||  | . |  ||.|.||. | ||| .. ..  ||.  || ||||||| |..|...||||.|.|||  ||...  .... |
ldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0043336 (Phosphotyrosine protein) phosphatases II 1-171 5.8e-46 152.5 In-house 97-276 (278) alignment 
Range on Protein: 1-171
Range on HMM: 97-276/278.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW-TGSKTHGEFSVEVNNERSANGYTERNLKLS--FDKETRSVLQFQVTDWPQDGVVRKAGTIL
...|| |||.|. ...|.|||||.....     |.|||  ||.|.|.|.|.. .| . ..|| |.|...   |.|.| |.... ..|| .||     ..|
lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

QVINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
. ...||..   . |||.||||. |.|.|... . ..|||  ||| ||.... |..|. .||||.|..||  .|...  |
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 1-171 2.5e-45 150.9 In-house 116-303 (307) alignment 
Range on Protein: 1-171
Range on HMM: 116-303/307.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW---TGSKTHGEFSVEVNNERSANGYTERNLKLS---FDKETRSVLQFQVTDWPQDGVVRKAG
...|| |||.|. ...|..||||......    |.|||    ...|.|.| |.. .|   .||| |.|...   ...|.| | .|. |.|| .||     
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfe

TILQVINDVRNRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
..|. |. ||. .    | |||.||||. |.|.|...   ..|.|  |||.   ||.... |..|. .||||...|||  .|...  .
elldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 1-171 6.3e-45 149.1 In-house 63-245 (249) alignment 
Range on Protein: 1-171
Range on HMM: 63-245/249.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW--TGSKTHGEFSVEVNNERSANGYTERNLKLS--FDKETRSVLQFQVTDWPQDGVVRKAGTI
...|| |||.|. ......||||. .. .    |.|||   ||...|.|.|.. .. . ..|| |.|.|.   |.|.| ||..|.|||| .||     ..
lpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedl

LQVINDVRNRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
|. |. ||. .    | |||.||||. |.|.|...   ..|||  ||. ||.... |..|. .||||...|||  .|...  .
ldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-175 1.1e-44 147.6 In-house 61-245 (250) alignment 
Range on Protein: 1-175
Range on HMM: 61-245/250.0
MENTVRDFWKMMVDYKVSTIVMLCG---DEDCCYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSFDKETRS--VLQFQVTDWPQDGVVRKAGTIL
...|. |||.|....|..|||||      |  . |||   .....|.  |.. ..     || |.||||  |.. .  | |.. . ||  || ..| ..|
lqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavL

QVINDVRNRQKR---GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
.....|.  |..   .||.|.||  |.||| .. ..  ||.  || |||||.| |..|. .|.||...||| ..| ||  .....
ellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0037934 (Phosphotyrosine protein) phosphatases II 1-170 4e-41 136.5 In-house 53-240 (243) alignment 
Range on Protein: 1-170
Range on HMM: 53-240/243.0
MENTVRD----FWKMMVDYKVSTIVMLCGDE----DCCYQYWTGSKTHGEFSVEVNNERSANGYTERNLKLSF---DKETRSVLQFQVTDWPQDGVVRKA
...|| |    ||.|. ......||||. ..      |.||| |..|.|.|.|.. .|.. ..|| |.|.|.    |..|| | ... . ||  ||    
lpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdsp

GTILQVINDVR----------NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCikeGvVDVFQVTKTVRRSKPG-AVTTQEQYDSIYDIIDL
  .|. ...||          .. . |||.||||  |.|.|...   . |...   | ||.... |..|. .|| ||.|..||  .|...  
edlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-174 1.3e-40 134.4 In-house 101-286 (297) alignment 
Range on Protein: 1-174
Range on HMM: 101-286/297.0
MENTVRDFWKMMVDYKVSTIVMLCGDED---CCYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSFDK--ETRSVLQFQVTDWPQDGVVR--KAGT
|..|| |||.|..|..|||||||  |..    | .||.  |..| |. ||...   . .|. .|.|... .|   .| | |.| ..||.. | |  .| .
mkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

ILQVINDVRNR---QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
.|..|..||.    .. ||..|||.  | | ||....   . .  .|  ||.|.. | .|...|  | |.|||  .| ..  .. .
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0045098 (Phosphotyrosine protein) phosphatases II 1-173 4e-39 130.1 In-house 73-273 (278) alignment 
Range on Protein: 1-173
Range on HMM: 73-273/278.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTGS--KTHGEFSVEVNNERSANGYTERNLKLS------FDKETRSVLQFQVTDWPQDGVVRK
...|| |||.|. ......||||.. ..     |.|||  .  .|.|.|.|.. .|   . || | |..        | |.| | ... . ||  ||   
lpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpsl

A--GTILQVINDVRNRQ---------------KRGPVVVHCSDTVSRSGVYCSVSIALEQCikEGVVDVFQVTKTVRRSKPG-AVTTQEQYDSIYDIIDL
     .|.... .|...               . |||.||||  |.|.|... . . ||..  ||.||.... |..|. .|| ||...|||  .|. . .
pilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

YVQ
...
lll
subfamily_Ptp69D_pd Subfamily Ptp69D 1-174 7.6e-38 125.3 In-house 100-288 (307) alignment 
Range on Protein: 1-174
Range on HMM: 100-288/307.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSFDK-------ETRSVLQFQVTDWPQDGVVR
.|.|. |||.|. . .| .||||   ..     | .||.    . .|.  |.. .|.... |..|.|..|  |       ..| |.|.. | |.   | .
veatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

KAGTILQVINDVR--NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
 | ..|..|. ||  ....|.|.|||||  |.|||.. .... |.|. .|  ||.|...| .|. ..  |.  |||  .|  .  | . 
vargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_CG7180_pd Subfamily CG7180 1-174 2.9e-37 122.9 In-house 94-292 (296) alignment 
Range on Protein: 1-174
Range on HMM: 94-292/296.0
MENTVRDFWKMMVDYKVSTIVMLCGDED---CCYQYWTGS--KTHGEFSVEVNNERSANGYTERNLKLSFD------------KETRSVLQFQVTDWPQ-
...|| .||... | ..|..|.|.   |    . .||     . .||. ||. .|..    . |..||                ||| |..||.| |.  
kketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele

DGVVRKAGTILQVINDVRN---R----QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
| |   . ....... ||    .    ...|||||..|| .||||||... ..||. .||. ||||.  ||.|||.|. | . |.|  |||..  .| .
dkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_PTPRK_pd Subfamily PTPRK 1-168 3.9e-37 122.8 In-house 95-273 (314) alignment 
Range on Protein: 1-168
Range on HMM: 95-273/314.0
MENTVRDFWKMMVDYKVSTIVMLCG-DEDC---CYQYWTG-SKTHGEFSVEVNNERSANGYTERNLKLSF----DKETRSVLQFQVTDWPQDGVVRKAGT
...||.|||... |.. ..||||    |     |..||   ....|.. ||. .    . .  | ....      .|.| | ||| . ||. .|  .| .
lqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

ILQVINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
.|...  | .   .. |..|||||    |.|... ..| |.   .|||||||.. ||.| .|.  | |.|||  |||.|
llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN6_pd Subfamily PTPN6 1-176 1.9e-36 120.7 In-house 107-301 (306) alignment 
Range on Protein: 1-176
Range on HMM: 107-301/306.0
MENTVRDFWKMMVDYKVSTIVMLCGDE----DCCYQYWTGS---KTHGEFSVEVNNERSANGYTERNLKLS---FDKETRSVLQFQVTDWPQDGVVRKAG
.|.|| |||.|... .   |||.  .     . |..||  .   ...|. ||.  .|.|.. |. |.|..|   ..||.|.| |.. ..||. || .. |
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg

TILQVINDVRNRQK------RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTTN
..|. ..||...|.       ||.|||||. . | | .  . | |..  |.|.   .|. .. |.||. . | | |..||  .| .|  |..|..
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-175 6.6e-36 118.8 In-house 82-271 (274) alignment 
Range on Protein: 1-175
Range on HMM: 82-271/274.0
MENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGSK------THGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAG
. ||| |||.|.   .|. ||||      .|. | .|.  ..      ..|.....|..  . |.|. |.| |.  ...|||  .  ||||   . ..| 
lpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddan

TILQVINDVRNRQ-----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
|.|.....|.. .     |..|||||||  . | |.. ..|||. |  .|.||||....  .|  . | | |.|||. |. .. ||.. .
tlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_PTPN3_pd Subfamily PTPN3 1-168 1.4e-30 101.2 In-house 93-271 (280) alignment 
Range on Protein: 1-168
Range on HMM: 93-271/280.0
MENTVRDFWKMMVDYKVSTIVMLCGD----EDCCYQYWT---GSKTHGEFSVEVNNERSANGYTERNLKLSFDK--ETRSVLQFQVTDWPQDGVVRKAGT
...|. |||.|. . |.|.||||          |.|||     . ..|||||....|.. . |  |.| |.  .  | |..||.| ..||. ||  ..  
laktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsad

ILQVINDVRNRQ--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
.|.... ||. .  |. |||||||  . |.||.  . .||    ..  | . .. .|.|  .   | |..||  . . |
flefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_PTPN14_pd Subfamily PTPN14 1-175 1.1e-22 75.4 In-house 102-299 (300) alignment 
Range on Protein: 1-175
Range on HMM: 102-299/300.0
MENTVRDFWKMMVDYKVSTIVMLCGD----EDCCYQYWTGS------KTHGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRK
.|.||.|||.|. . .|. ||||  .     . ...|.  .       ..|.| |  .  .... .. . ||| .   || |.|. .| ||||..|| . 
leltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeD

AGTILQ---VINDVRNRQ--------KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
  . |.    .. ||..         .. ||.||||. | |.||   . . ..   .. ..|. .| ...|. .   | |  ||  .|...  |.. .
vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-168 5e-22 73.2 In-house 81-255 (267) alignment 
Range on Protein: 1-168
Range on HMM: 81-255/267.0
MENTVRDFWKMMVDYKVSTIVMLC-GDEDCCYQYWTGS----KTHGEFSVEVNNERSANGYTERNLKLSFDKET-RSVLQFQVTDWPQDGVVRKAG-TIL
..||. ||.... |.||..||.|    .|   ..|       | . ...|| . |.  | |    |.| | .|. . |  .    |  .   .     ..
lkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplf

QVINDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
 ..   .  .   |.||.||| | ||| .  .   ||.  .|||.|.|.  . .|  ..| | |.|.|  |....
gilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-175 3.4e-21 70.3 In-house 89-280 (287) alignment 
Range on Protein: 1-175
Range on HMM: 89-280/287.0
MENTVRDFWKMMVDYKVSTIVMLC-GDE---DCCYQYWTGSKT---HGEFSVEV-NNERSANGYTERNLKLSfDKETRS---VLQFQVTDWPQDGVVRKA
.  ||||||..... ........    |     ||.||   .     | .|| . . .     |. | |.|  | |||    | |... .||....   |
iaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPta

GT----ILQV---INDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
      .|.|   |.  |. .. ||.|||..  . |||.. .. . ...  . | ||| .|   .|  . . | .  |.  .|. .  | .| 
vglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
0049772 (Phosphotyrosine protein) phosphatases II 1-174 9.9e-17 57.1 In-house 93-282 (314) alignment 
Range on Protein: 1-174
Range on HMM: 93-282/314.0
MENTVRDF----------WKMMV--DYKVSTIVM---------------------LCG---DEdccyqywtgS----------Kthgefsvevnnersan
.|.|| ||          |.|..  |..| .|||                     |..              .          |                
leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.........neptaadlellk................

gyT-------ErnlklsfdkeTRSVLQFQVTDWPQdGVVRKAGTILQVINDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCikeGVvDVFQVTKTV
  .                  .| ....  ...|  | .     ...... ... .| |||.|||.. ..|.|... . . . ..   || .. .. . |
..eelydpelf..........erlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedv

RRSKP-----GAVTTQEQYDSIYDIIDLYVQT
|.  |     |.. ..|||  |....  |...
rlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1-160 3.3e-16 53.9 In-house 99-269 (301) alignment 
Range on Protein: 1-160
Range on HMM: 99-269/301.0
MENTVRDFWKMMVDYKVSTIVMLCGD----EDCCYQYWTGSKT----HGEFSVEVNNERSA--NGYTERNLKLS---FDKETRSVLQFQVTDWPQDGVVR
..||  ||| |.| |.| .||||.      |. | .| . . .     | |.....|. .   .  ..|.|..     . .||.|. .| ..|.. || .
lkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPk

KAGTILQVINDVRNRQKrgPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQ
    . .... |.. .|  |.|||||. . ||  . .  .   .   .  ... .  | .|  .  .| |..|
shaelfdlmelvkksek..PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_egg_pd Subfamily egg 1-172 7.3e-16 52.7 In-house 92-270 (307) alignment 
Range on Protein: 1-172
Range on HMM: 92-270/307.0
MENTVRDFWKMMVDYKVSTIVMLCGD--EDCCYQYWTGSKT------HGEFSVEVNNERSA--NGYTERNLKL-SFDKETRSVLQFQvTDWPQDGVVRKA
. ||| |||.|.   .|  ||||      . |  ||  ...       | . .|  .  |.    ..  .|||   |.| | .  .|  |. . . |   
lkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysp

gtiLQVINDVrnRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVV--DVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
   |.|.  .  |.   ||||.. . ||....  .. ||| . ..  ..   | .  . .|. .. .| .  .|  .| .. ...
...lrvlrkl..rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1-166 2.6e-15 51.1 In-house 13-197 (198) alignment 
Range on Protein: 1-166
Range on HMM: 13-197/198.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDCCY----QYWT----GSKTHGEFSVEVNNERSANGYTERNLKLSFD----KETRSVLQFQVTDWPQDGVVRK
. .|. |||.|. .     |||.  |.         ||     |.  .| .|| ..   .   ||   | |. .      || . ..| | | .      
lretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnv

AGTILQVIN-----DVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALE--QCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
|  .  |.         ...|  ||.|||||    .||. .. | .   .  |  |||.|.|.| .|... | ... ..|. ||.
alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1-166 2.8e-15 51.0 In-house 14-198 (199) alignment 
Range on Protein: 1-166
Range on HMM: 14-198/199.0
MENTVRDFWKMMVDYKVSTIVMLCGDEDCCY----QYWT----GSKTHGEFSVEVNNERSANGYTERNLKLSFD----KETRSVLQFQVTDWPQDGVVRK
. .|. |||.|. .     |||.  |.         ||     |.  .| .|| ..   .   ||   | |. .      || . ..| | | .      
lretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnv

AGTILQVIN-----DVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALE--QCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
|  .  |.         ...|  ||.|||||    .||. .. | .   .  |  |||.|.|.| .|... | ... ..|. ||.
alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-168 8.7e-14 46.2 In-house 91-267 (288) alignment 
Range on Protein: 1-168
Range on HMM: 91-267/288.0
MENTVRDFWKMMVDYKVSTIVMLCG-----DEDcCYQYW---TGSKThgEFSVEVNNERSANGYTERNLKLSFDKETRSVLQF------QVTDWPQDGVV
.. |.  .|||...  |  |||||       |    .|.    | |.   .    .  .  .   .. .|.|  . .. . .        . .|..||| 
lngtieelWkmllesdveyivmlcellekGkek.saeyfPsklGeka..rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP

RKAGTILQVINDVRNRQKrgPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
 .  . |.... ... ||  |.|||.|  | |.|    . ||||.   .  . . .. .  | ..  |..|. ||  .. ..
enylsplrllevlkslqk..PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-173 4.9e-13 43.5 In-house 97-288 (305) alignment 
Range on Protein: 1-173
Range on HMM: 97-288/305.0
MENTVRDFWKMMVDYKVSTIVMLCG-----DEDcCYQYWTG-SKTHGEF-----SVEVNNERSANGYTERNLKLS----------FDKETRSVLQFQVTD
.|.|  ||| | .. || .| |||       .  |..|..   |   ||      . |  | |..   ... |              ...| | ..   |
lektcadfwymclqdkveaifmlcnllekgakk.cleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwid

WPQDGVVRKAGTILQVINDVrnRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVD-VFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQ
||. ||     .||.....   |  .||.|||||  . |.|    .   |.| .   ...   .. . .|  .  .. |..||  ....|  |..
wpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1-162 3.9e-11 37.2 In-house 91-266 (312) alignment 
Range on Protein: 1-162
Range on HMM: 91-266/312.0
MENTVRDFWKMMVDYKVSTIVMLCGD----EDCCYQYWTG---------SKTHGEFSVEVN-NERSANGYTERNLKLSFDKET--RSVLQFQVTDWPQDG
.|||.  ||.. .    ..|..|||      . | .| .           . . |.  |..   .| .  | | ||.          . ..| . ||. |
lentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhg

VVRKAGTILQVINDVRNRQKrgPVVVHCSDTVSRSGVYC---SVSIALEQCIKEGVVDVFQVtktVRRSKPGAVTTQEQYD
.     | |...  |.. .|  ||. |||  | |.|  .   |.  || .  |. | |.| .   .|. .  .| .  || 
mpdscdtalrllsavkkdkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-176 1.6e-46 153.8 In-house 101-287 (319) alignment 
Range on Protein: 2-176
Range on HMM: 101-287/319.0
ENTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWTGSK--THGEFSVEVNNERSANGYTERNLKL---SFDKETRSVLQFQVTDWPQDGVVRKAGTI
|||. |||.|. ....|..|||... .     . .||.  .  . |.. |....|.  ..|  |.|||   | . |||.| .|| |.||...| .|| ..
entiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LQVINDVRNRQKR---GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTTN
|......|. ...   ||.|||||. | | | .. ....||.  .|||.|||.. ...|  ..  | ..|||  ||...  .|.. .
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0042113 (Phosphotyrosine protein) phosphatases II 2-171 1.1e-42 141.5 In-house 62-242 (245) alignment 
Range on Protein: 2-171
Range on HMM: 62-242/245.0
ENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYW--TGSKTHGEFSVEVNNERSANGYTERNLKLS--FDKETRSVLQFQVTDWPQDGVVRKAGTIL
..|| |||.|. .....|||||. .|.     |.|||   .|.|.|.|.|.. .| . ..|| |.|...   |.|.| |.... ..|| .||     ..|
petvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllelll

QVINDVRN---RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
.... ||.   . . |||.||||. |.|.|... . ..|||  ||. |..... | .|. .||||.|..||  .|...  .
dflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-174 6.8e-42 138.6 In-house 99-282 (318) alignment 
Range on Protein: 2-174
Range on HMM: 99-282/318.0
ENTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSFD--KETRSVLQFQVTDWPQDGVVRKAGTIL
 .|..|||.|. . . ..||||   |.     . .||   ||...|.  ||...| . . |. |..|.. .  .|.| | |...|.||. ||  .....|
petieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasll

QVINDVRNRQ---KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
... .|.. |   ..||.|||||  | | ||.. |.| ||.  .|..|||||. |..|. ..  | |..||. |||..  ....
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPN12_pd Subfamily PTPN12 2-174 3.7e-39 129.3 In-house 93-279 (290) alignment 
Range on Protein: 2-174
Range on HMM: 93-279/290.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGS----KTHGEFSVEVNNERSAN-GYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTI
 .|. |||.|. ...|. .||.|     .   | .||. .     ..|||.|....|.  . ... | ||. ..||.|.| ||. |.||  || ..| ..
pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksl

LQVINDVRNRQKR--GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
|..|..||..|..   |.|||||  | | |. ... .. |.  .| .   .|||..  ..|. .. .| |.|||  .|  .  .||.
lelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-168 1.3e-38 127.5 In-house 85-262 (283) alignment 
Range on Protein: 2-168
Range on HMM: 85-262/283.0
ENTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYW--TGSKTHGEFSVEVNNERSANGYTERNLKLSFD---KETRSVLQFQVTDWPQDGVVRKAGTI
..||.|||||. | |...||||     . .  | |||   ||. .||| | ...| . | .. ..| |  .   |.|  .  .|| || . |      ..
drtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinsl

--LQVINDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
  .  .   ....|.||.||||| .. |..|....| ....   | |||||.| | .|  ...|| |..||  .....
vkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPRA_pd Subfamily PTPRA 2-171 6.6e-38 125.4 In-house 111-294 (330) alignment 
Range on Protein: 2-171
Range on HMM: 111-294/330.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYW--TGSKTHGEFSVEVNNERSANGYTERNLKLS------FDKETRSVLQFQVTDWPQDGVVRKA
|.|| |||.|. ..| .|||||      .|. |.|||   |. |.|.  |||..|  .. || |.. .        .|..| | ||  | ||. ||  ..
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

GTILQVINDVRN--RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
  .|.... |..  .|. ||.|||||  | |.| .. ..  ||.   |..||||.. | .|  .|  | |.|||  || ..  |
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-168 1.1e-35 118.1 In-house 100-275 (288) alignment 
Range on Protein: 2-168
Range on HMM: 100-275/288.0
ENTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTGSKT---HGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQ
 .|| |||... ..|.||||||     |..  | .||  ...   .|.. |.. ...  . ...|.| |  .|. . . |.| . ||..|| . .  .|.
adtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskaplle

VINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
... | .   .. ||..||||. | |.|.. ..  ....  .| ..||. . . .|....  | |..||  ||...
llrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_PTPRG_pd Subfamily PTPRG 2-175 4.1e-35 116.0 In-house 101-290 (563) alignment 
Range on Protein: 2-175
Range on HMM: 101-290/563.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSF------DK--ETRSVLQFQVTDWPQDGVVR
..|. |||.|. . .|..|||.          | .||   .|.| |...|   .|     ||.|.|..        ..  . . | |.. |.||. ||  
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

KAGTILQVIND--VRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
..   |. ..     |... ||.|||||  |.|.|.|. ..  |.|  .| .|.||.. |..|  ..  |.|.|||  ..|..   ... 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_PTPRB_pd Subfamily PTPRB 2-173 4.7e-34 112.8 In-house 104-286 (293) alignment 
Range on Protein: 2-173
Range on HMM: 104-286/293.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGS---KTHGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQ
 .|| |||.|. . |.|.||||          | .||       ..|. .|....|.. . .. |.||.. .||.|.| |.. | ||. ||  |. |.|.
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlld

VINDVRNRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQ
 .. ||...    ...|.|||||  | |.|.. ..   |..  .| .||.| .   .|...   | |..||  |.. .  ...
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-166 2.3e-33 110.8 In-house 114-285 (319) alignment 
Range on Protein: 2-166
Range on HMM: 114-285/319.0
ENTVRDFWKMMVDYKVSTIVMLCgdEDCCYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSF---DKETRSVLQFQVTDWPQDGVVRKAGTILQVI
.||. |||.|. .|..||||.|   .| | |||   . .....| |.|.    .. |. |...||     |. |.. ||    ||. ||   .  .....
dntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

NDVR----NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
. ||      ..| ..|||||  | |.|||  . . |..  .|  |||... . .|. ..  |    ||  || 
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-166 3.7e-33 110.2 In-house 78-249 (284) alignment 
Range on Protein: 2-166
Range on HMM: 78-249/284.0
ENTVRDFWKMMVDYKVSTIVMLCgdEDCCYQYWT--GSKTHGEFSVEVNNERSANGYTERNLKLSF---DKETRSVLQFQVTDWPQDGVVRKAGTILQVI
.||. |||.|. .|..||||.|   .| | |||   . .....| |.|.    .. |. |...||     |. |.. ||    ||. ||   .  .....
dntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlv

NDVR----NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
. ||      ..| ..|||||  | |.|||  . . |..  .|  |||... . .|. ..  |    ||  || 
kkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2-175 1.3e-31 104.6 In-house 74-267 (270) alignment 
Range on Protein: 2-175
Range on HMM: 74-267/270.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGSKTH------GEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAG-
..|...||.|... ||..|||. |      . | .||. .. .      |. .| . .|. ..||  ..|.|  . |.| .. |. ..||..||.|... 
pttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreeds

-----TILQVINDVR---NRQKRG-PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQTT
      .|.....||   ...... |..||||. | |.|.   . ||..   ... ||| .. . .|. ..  | . |||  .|  . .|....
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN23_pd Subfamily PTPN23 2-174 1.3e-30 101.2 In-house 93-282 (288) alignment 
Range on Protein: 2-174
Range on HMM: 93-282/288.0
ENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTG----SKTHGEFSVEVNNERSANGYTERNLKLSFDK--ETRSVLQFQVTDWPQDGVVRKAGT
..|. |||.|... |.|.||||   |.     . .||      ....|..|| ....|... . ||.|||.. .  ...||   |.| ||. ||    .|
qstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPet

ILQVINDVRN------RQKRGPVVVHCSDTVSRSGVYCSVSIALEQC-IKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
.||... |..      |. . |.|||||  | |.||.. |  |...   ..|..|. || ...|. .   | ..||.   |...  ... 
llqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
0051429 (Phosphotyrosine protein) phosphatases II 2-171 9.8e-29 96.2 In-house 32-224 (272) alignment 
Range on Protein: 2-171
Range on HMM: 32-224/272.0
ENTVRDFWKMmVDYKVSTIVMLCGDE----DCCYQYWT--------------GSKTHGEFSVEVNNERSANGYTERNLKLS---FDKETRSVLQFQVTDW
..|..|||..  .....|||.|...|    . |..||                . ..| ..| .  |   . |. |.| |.     .|.| |.... |||
pltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

PQDGVVRKAgtILQVINDVRNrqkRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVD--------VFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
| .|| ..|  .|.... ...    |||.||||  ..|.|... . . |..  .| .||        .... . .|.  |||| |.|||  .|...  .
pdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-168 6.5e-28 92.5 In-house 55-235 (237) alignment 
Range on Protein: 2-168
Range on HMM: 55-235/237.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTG---SKTHGEFSVEVNNERSANGYTERNLKLSFD---KETRSVLQFQVTDWPQDGVVRKAGT
|..  |||.|. . | | |||| |    .|  |..||      ...| ..| .  .     || | | ||     || | . |.| | ||. || ... .
esscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa

ILQVINDVRNR----QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
.|.   .. ||    .. || ..|||  | |.|..  .   | |. .. |||...  ...   .|  . |..||  |.. |
llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 2-171 6.5e-28 92.9 In-house 44-170 (182) alignment 
Range on Protein: 2-171
Range on HMM: 44-170/182.0
ENTVRDFWKMMVDYKVSTIVMLCgdedcCYQYWTgskthgefsvevnnersangyternlklsfDKETRSVLQFQVTDWPQDGVVRkAGTILQVINDVRN
 .|| ||..|. .....|||.|.     ...||                               ....| ..|.. . || .||     ..|. |..|..
lstvadflrmlkelgittivnlt.....eelywp..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle

rqKRGPVVVHCSDTVSRSGVYCSVSIALEQcikeGvVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
  . |||.||||  |.|.|...   . ...    | |..... |.||. .||.|.| .||  ..... ..
..eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_PTPN9_pd Subfamily PTPN9 2-172 1.2e-27 91.8 In-house 95-290 (297) alignment 
Range on Protein: 2-172
Range on HMM: 95-290/297.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWT----GSKTHGEFSVEVNNERSANGYTERNLKLS--FDKETRSVLQFQVTDWPQDGVVRKAGT
..||.|||.|. . .| .|||           | |||      |. .|..||.. . .. . |..| |...   ..|.|.|  ||.. ||  || . | .
kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaas

ILQVINDVRNRQK---------------RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
.|.|.. ||..|                  |.|||||  . |.| .... |.|..  ..|.|||... |..|  .  .. |.|||   |  .  | 
lldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2-168 1.7e-26 87.7 In-house 101-275 (439) alignment 
Range on Protein: 2-168
Range on HMM: 101-275/439.0
ENTVRDFWKMMVDYKVSTIVMLCGDEDcCYQYWTGSK--THGEFSVEVNNERSANGYTERNLKLSFDK----ETRSVLQFQVTDWPQDGVVRKAGTILQV
..|. |||..... |..|||||.   .  |.||  ..   .|. .| |. .     |. | .|.  ..      |.||||. . ||.  |  .|  .|. 
kettddfwrlviekktvtivmltnlve.sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

---INDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
   ||   .... ||||||||  | |.|   .. |||||   |  ||.  . | .|. .   | .  ||  ||. .
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0043147 (Phosphotyrosine protein) phosphatases II 2-165 7.1e-25 83.1 In-house 30-154 (172) alignment 
Range on Protein: 2-165
Range on HMM: 30-154/172.0
ENTVRDFWKMMVDYKVSTIVMLCGDedccyqywtgskthgefsvevnnersangyternlKLSFDKETRSVLQFQVTDWPQDGVVrKAGTILQVINDVRN
 ||. |||.|. ......||.|..                                     .  ....|...|.. . ||  ||   .  .|.... ...
rntladfwrmlkelgithivnltel...................................lydpellerlgiqylylpwpDhgvp.llellleflefide

---RQKRGPVVVHCSDTVSRSGVYCSVSIALeqcikeG-VvDVFQVTKTVRRSKPGAVTTQEQYDSIY
   ... |||.||||  |.|.|. .   . |        . ..... ..||. .||||....||  .|
llalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2-167 1.2e-24 81.5 In-house 246-433 (440) alignment 
Range on Protein: 2-167
Range on HMM: 246-433/440.0
ENTVRDFWKMMVDYKVSTIVMLCGDED-CCYQYW---TGSKTHGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWP----QDGVVRKA---G
. || |||... ||..|||.||   .|  |  ||   | | | | |.|  .     |    | |.| . .|   . ||.|  ||     |||  .     
dstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwiqsdgvqsqeqcmd

TILQVINDVRN-------RQKR----GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDI
..||... .|.        | |     |..|||   .  |||.|.|   |||  ..| .||||  . .| |.|  | |  .|   | .
avlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykl
0046846 (Phosphotyrosine protein) phosphatases II 2-171 2.5e-24 81.4 In-house 33-172 (176) alignment 
Range on Protein: 2-171
Range on HMM: 33-172/176.0
ENTVRDFWKMMVDYKVSTIVMLCGDEDC----CYQYWTGSKTHGEfsvevnnersangyternlklsfdketrsvlQFQVTDWPQDGVVRKaGTILQVIN
..|. ||..|. .......|.|. . .     |..||   ...|                                |.....||  ||      .|....
prtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................qylhlpwpDhgvpdl.elllelle

DVRNRQKRG-PVVVHCSDTVSRSGVYCSVSialeQCIKEGVVDVFQVTKTVRRSKP-GAVTTQEQYDSIYDIIDLY
 .|...|.| ||.||||  ..|.|...        ...|  ..|... ..||. .| |||.|.|||  .|. . |.
firealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefelll
0049260 (Phosphotyrosine protein) phosphatases II 2-166 1.2e-23 78.9 In-house 19-144 (152) alignment 
Range on Protein: 2-166
Range on HMM: 19-144/152.0
ENTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWtgskthgefsvevnnersangyternlklsfdketrsvlQFQVTDWPQDGVVRKAGTILQVIN
.||. |||.|. .....|||||. ...    .|.||.                                       |.. . || .||   .  .|... 
pntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlpwpDhgvpdlsqlllflll

DVRN--RQKRGPVVVHCSDTVSRSGVYCSVSIALeqcikeGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
 ..   ..| |||.||||  |.|.|...   . |        |..... . ||. .||||....|.  .|.
fieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN1_pd Subfamily PTPN1 2-165 1.4e-23 78.1 In-house 81-264 (290) alignment 
Range on Protein: 2-165
Range on HMM: 81-264/290.0
ENTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTGSKT-------HGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRK
 |||  ||.|. . |  ..|||      ..  |.|||   .        . ...|.. .| . . || | |.|     .|||..|.|  | ||  || . 
pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpes

AGTILQVINDVRNR----QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTQEQYDSIY
 .. |. . .||.     .. ||.|.|||  . ||| .| |   | .  |..    ||. .|   .|. . | . |..| .  |
paaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_PTPRN_pd Subfamily PTPRN 2-168 2.3e-23 77.4 In-house 110-288 (297) alignment 
Range on Protein: 2-168
Range on HMM: 110-288/297.0
ENTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYW--TGSKTHGEFSVEVNNER-SANGYTERNLKL--SFDKETRSVLQFQVTDWPQDGVVRKAGTI
 .|| |||.|. .  |  ||.|.  |.     |..||  .||.... . |..  |   .. |  | . |     .|||.| ||    ||. ||  .| ..
astvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksl

LQVINDVRN--RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKeGV--VDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
|.    |    | .  |.|||||| . |.|||. . . |.. .| ||  .|.    . .|  .|| | |..|.. ..  .
lefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllk.Gvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-168 1.1e-20 68.5 In-house 104-279 (290) alignment 
Range on Protein: 2-168
Range on HMM: 104-279/290.0
ENTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGS----KTHGEFSVEVNNERSANGYTERNLKLSFDKE-TR--SVLQFQVTDWPQDGVVRKAG
..|| |.|.|... ||..|||||         | ||.        | ||..|   .| . .  . ...    ||.  .   .  ...  ||.  |   . 
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl

TILQVINDVRnrQKRGPVVVHCSDTVSRSGVYCSVSIALeQCIKEG-VVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
..|...  .|  .  ||||||||  . |.| . .. ..| |.. .|  .|. .. ...|.|. ..|  . ||  . .|.
allrtlrilr..kasGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2-172 7.6e-20 66.2 In-house 77-259 (290) alignment 
Range on Protein: 2-172
Range on HMM: 77-259/290.0
ENTVRDFWKMMVDYKVSTIVMLCGDED--------CCYQYWTGSK----THGEFSVEVNNERSANGYTERNLKLSFDKETRS-VLQFQVTDWPQDGVVRK
. |. .|| |. . ||  .||||  |.         | .|   |     . . ..|.  .    ..  .|.| . ||.|    |   .. .| .  | ..
nStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqed

AGTILQVINDVRnrQKRGPVVVHCSDTVSRSGVYCSVSIALEQCI-KEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
  |.|..|. |.  ... ||.||| | .||| .  .. ..    . ..| | . .| |..|. .  |.|.....  .   | |..
tktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2-168 1.5e-19 65.1 In-house 92-273 (307) alignment 
Range on Protein: 2-168
Range on HMM: 92-273/307.0
ENTVRDFWKMMVDYKVSTIVMLCGDE----DCCYQYWTGSKTHGEFS------VEVNNERSA------NGYTERNLKLSFDKETRSVLQFQVTDWPQDGV
|||. .|| |... || ...|||         | |||   .            . |.|  .       .     .||. . ...|.. ..| ..||. ||
entqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgv

VRKAGTILQVINDVRNRQkrGPVVVHCSDTVSRSGVYCSVSIALEQCIK-EGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
 .   | . ... ||  .   |||||||  | |||   ..|.  .. |. .   |. .. . .|  .. |. |. ||  .. ..
pqinltainlleavrydt..npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2-171 2.5e-17 57.5 In-house 106-288 (305) alignment 
Range on Protein: 2-171
Range on HMM: 106-288/305.0
ENTVRDFWKMMVDYKVSTIVMLCGDE----DCCYQYWT---GSKTHGEFSVEVNNERSA---NGYTE---RNLKLSF-DKETRSVLQFQVTDWPQDGVVR
..|. .|| |... ||  |||||         | |||    | | .    . |.|   .   .  .|     |.|..  ... || ..| |.||. ||  
dqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvpp

KAGTILQVINDVRNrqKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEG-VVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
   | |...  .|    . |.|||||  . |.|   ..   ||.  ..  .  . .. |..|  .  .. .. ||  |. ..  |
ckltslellsairg..skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_ptpA1_pd Subfamily ptpA1 2-130 1.9e-14 48.2 In-house 99-254 (418) alignment 
Range on Protein: 2-130
Range on HMM: 99-254/418.0
ENTVRDFWKMMVDYKVSTIVMLCGD-EDC---CYQYWTG-------------SKTHGEFSVEVNNE--RSANGYTERNLKLSFDKETRSVLQFQVTDWPQ
 ||. |||.|. . ..  ||||  . |.|   | .||                .  | .|||. .           ||..|.|. ||| . |.|   ||.
pntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpd

DGVVRKAGTILQVINDVRNRQK--------RGPVVVHCSDTVSRSGVYCSVSIALE
  .  ..  . |..  . |||.          |..||||  | |.| .|.  | ..
hnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2-174 6.6e-14 46.0 In-house 103-287 (302) alignment 
Range on Protein: 2-174
Range on HMM: 103-287/302.0
ENTVRDFWKMMVDYKVSTIVMLCGDEDCCY---QYWT-GSKTHGEFS-VEVNNERsANGYTER----NLKLSFDKETRSVLQF--QVTDWPQDGVVRKAG
|. | .||.|. . |. ..|.| |.|.. .   ...   | .. |.  . ||| .  .   |      . .  .  . |||     .| |.|. |  | .
edsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

TILQVINDV--RNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQT
.. . . .|  .. .   ..|.     . | |.  .. .|.|.  |.  . . .. |..|  .| || . .|| |.| .. ||...
eliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2-166 2.2e-10 34.6 In-house 104-284 (310) alignment 
Range on Protein: 2-166
Range on HMM: 104-284/310.0
ENTVRDFWKMMVDYKVSTIVMLCGD--E--DCCYQYWTG---SKTHGEFSVEvNNERSANGYTERNLKLSFDKETR-------S-----VLQFQVTDWPQ
. |. |||.|. . .  .|..||    |    |  ||     ..|.|   |  |   |.. .   || ..|  .               |   .  .||.
qhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

DGVVR-KAGTILQvinDVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
 ||   |  |. |    .  . . ||.|||||  . | .| ... .....  .   ||. .|   ...|.   . |. ||  |  
rgvpdekchtvpq...rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2-86 1.5e-09 32.2 In-house 86-180 (297) alignment 
Range on Protein: 2-86
Range on HMM: 86-180/297.0
ENTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTG----SKTHGEFSVEVNNERSANgYTE---RNLKLSFDKETRSVLQFQVTDWPQDGVV
..|| |||.....  | .|||..    .  | |. ||       .. |.. ||   . | . .      .|.| . .|.| |   |   ||. || 
satvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvp
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-173 8.8e-40 131.5 In-house 98-278 (315) alignment 
Range on Protein: 3-173
Range on HMM: 98-278/315.0
NTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTG----SKTHGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQ
 .| |||.|....||.||||.     ||   | |||      |   |...||. .  .  . . |.| .   .|.| | ||| |.||. || ......|.
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllk

VINDVR--NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQ
.| .|.  |..|  ...||||  | |.|| .|.   ..|  .. .||||.. |..|. .|  | |.|.|  |||..  ...
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3-171 1.2e-37 124.5 In-house 103-279 (315) alignment 
Range on Protein: 3-171
Range on HMM: 103-279/315.0
NTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTGSK-THGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQVIN
..|.|||... ......||||     |..  . .||   | ..|...|   .|   . || | |   |... | |.|...| ||. || . . .....| 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlir

DVRN--RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII-DLY
 |.    .. |..|||||. | |.| .....  |.|   | ..||... . ||. . ..| . |||. |||.. . .
tvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-172 5.2e-37 122.1 In-house 97-276 (515) alignment 
Range on Protein: 3-172
Range on HMM: 97-276/515.0
NTVRDFWKMMVDYKVSTIVMLC----GDEDCCYQYWTG----SKTHGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQ
 .| |||.......|.||.|.     ||   | .||      |   |...||.    .  | . |.|..  ....| | ||. |.||. || ... ..|.
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllk

VINDVRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
.| .|.    |   |...|||  | | ||..|.   . .  .  .||||.. . .|. .|  | |||||  ||...  ..
likevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-171 4.9e-32 106.3 In-house 102-287 (325) alignment 
Range on Protein: 3-171
Range on HMM: 102-287/325.0
NTVRDFWKMMVDYKVSTIVML---CGDEDCCYQYWTG----SKTHGEFSVEVNNERSANGYTERNLKLS--FDKETRSVLQFQVTDWPQDGVVRKAGTI-
.|. |.|....|.. | .|.|    ...| | .||      ||| | . |..        |  | |..    . ||||| |||.  |.. || ..  |. 
atindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli

--LQVINDVRNR-----QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
  ||... | .|     .  .|..||||. | |.||. |.  ||.. |.|  ||.|.. | .|. .|  | | .||  ||. .  .
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-173 2.9e-29 97.0 In-house 95-277 (281) alignment 
Range on Protein: 3-173
Range on HMM: 95-277/281.0
NTVRDFWKMMVDYKVSTIVMLCGD----EDCCYQYWTGSK---THGEFSVEVNNERSANGYTERNLKL-SFDKETRSVLQFQVTDWPQDGVVRKAGTILQ
... .||.|....|||.|||.  .       |..||   .   . |.. |. ..|.. . | ||..||   . |||.| |.. | ||. ||  ..  .|.
aslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkelle

VINDVRN---RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKE-GVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYVQ
  ..|..   ...  |.|.|||  | |.|.| ..  ..... .|   .|| .| . .|...   | |  ||. .| ..  ...
frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN13_pd Subfamily PTPN13 3-168 5.2e-28 93.1 In-house 88-265 (273) alignment 
Range on Protein: 3-168
Range on HMM: 88-265/273.0
NTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWTGSKT-----HGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRKAGT
.||.|||.|. . |.. |.|.  . .     | .||  ||      .. . ||. .    .|.. |.|...    .|.| | ... ..||  || ..|  
etvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaae

ILQVINDVRNRQK-RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
.||..  ||. |. .||.|||||  . |||.. .. ..|.   ..  .|| .. ...|. . | | |..||  .| .|
llqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-168 2.2e-25 83.9 In-house 99-232 (392) alignment 
Range on Protein: 3-168
Range on HMM: 99-232/392.0
NTVRDFWKMMVDYKVSTIVMLCGDE--DccyqywtgskthgefsvevnnersangyternlklsFDKETRSVLQFQVTDWPQDGVVRKAGTILQVINDVR
 .. |||.|. . .|.||.|.   .  |                                      ...|.| ||..|.||...| ... ..|..|..|.
aslddfwrmvfqenvttiamvtklkegd....................................kgddartvaqfhftewPdkdvpkhtssllkfikevk

NR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
    |   |...|||  | |.||  |.   . .. |  .||||..   .|| .|  | |.|||  ||  .
adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3-168 1.4e-18 61.5 In-house 92-265 (281) alignment 
Range on Protein: 3-168
Range on HMM: 92-265/281.0
NTVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGS----KTHGEFSVEVNNERSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQ
.|  |||.|. . . ..|||||     . . | .|.           ..||. ..    .      |.||.. ||| . ..   .||.  |   .  .|.
etradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk

VINDVRNRQkrGPVVVHCSDTVSRSGVYCSVSIALEQCIK-EGVVDVFQVTKTVRRS-KPGAVTTQEQYDSIYDII
..  .| |    | |.|||  | |||   .| |||.       . |. |.   .| . .  .| | .||  |. ..
ilrkirars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_hpo-7_pd Subfamily hpo-7 3-173 5.5e-11 36.9 In-house 45-229 (263) alignment 
Range on Protein: 3-173
Range on HMM: 45-229/263.0
NTVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWTGSKT----HGEFSVEVNNERSANGYTERNLKLSFD--KETRSVLQFQVTDWPQDGVVRKAGTI
.|.  |....|  | ...||||  ..     | .|.   |       . .| . .  |      ..|   ..  |.|. | ... . |..   ...|  |
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQVINDVRNRqKrgPVVVHCSDTVSRSGVYCSVSIALEQCI------KEGVVDVFQVTKTVRRSKPGAVTTQEQYD-SIYDIIDLYVQ
|.... .||  |  ..|||||  . ||  .  . ..  . |      . . .|  .. . .| |...|. |  |   ||. ..|. ..
lnilkvarns.k..slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3-169 2.7e-09 31.4 In-house 86-267 (285) alignment 
Range on Protein: 3-169
Range on HMM: 86-267/285.0
NTVRDFWKMMVDYKVSTIVMLC-----GDEDCCYQYWT--G-SKTHGEFSVEVN--NERSANGYTERNLKLSFDKETRS----VLQFQVTDWPQDGVVRK
.|. |||.|. . |.. ..|||     | | |.  |    |     |.. . .   .| .  |    .| .   ... |    . . ||  ||..     
etlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlaped

AGTILQVINDVRN-RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIID
|  .... . |..   |  |..||||  | |.  .  .  |  . ...  ...... . .|  .  || .. |.  .| .. 
arpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 3-86 4.6e-07 24.2 In-house 39-127 (130) alignment 
Range on Protein: 3-86
Range on HMM: 39-127/130.0
NTVRDFWKMMVDYKVSTIVMLCGDEDcCYQYWTGSKTHG--EFSVEVN--NERSANGYTERNLKLSFDKET--RSVLQFQVTDWPQDGVV
.|  ||||||..  |  .|.|   |.   .||  |.     |  . |   .    .     ||. . |     ...  ||...|| ||  
dtsmdfwkmmleryvnvlvvlgsvee.edeywpdsePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdgtt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3-86 9.5e-07 22.7 In-house 148-236 (244) alignment 
Range on Protein: 3-86
Range on HMM: 148-236/244.0
NTVRDFWKMMVDYKVSTIVMLCGDEDcCYQYWTGSKTHG----EFSVEVNNERSANGYTERNLKLSFDK-E-TRSVLQFQVTDWPQDGVV
.|  ||||||.. .|  .|.|   |.   .||  |.       . .| . .          ||..  |  |  ...  ||...|| ||  
dtsmdfwkmmlerhvnvlvvlgsvee.edeywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4-165 3e-23 77.2 In-house 64-234 (239) alignment 
Range on Protein: 4-165
Range on HMM: 64-234/239.0
TVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGSKT-HGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRKAGTILQVI
.  |||.|| . .   |||| |     .  |.|||  | . . .. | . .      |  | . .|   . | | | |...| ||. || . | ..| . 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr

NDVRNRQKRG--PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIY
  . .    |  | |.|||  | |.| .  .   | |. |.  ||.|.  |..|  .|  | | |||  |.
rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-165 3e-23 77.2 In-house 63-233 (239) alignment 
Range on Protein: 4-165
Range on HMM: 63-233/239.0
TVRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWTGSKT-HGEFSVEVNNERSANGYTERNLKLSF--DKETRSVLQFQVTDWPQDGVVRKAGTILQVI
.  |||.|| . .   |||| |     .  |.|||  | . . .. | . .      |  | . .|   . | | | |...| ||. || . | ..| . 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr

NDVRNRQKRG--PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIY
  . .    |  | |.|||  | |.| .  .   | |. |.  ||.|.  |..|  .|  | | |||  |.
rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4-168 6.2e-12 40.1 In-house 40-218 (255) alignment 
Range on Protein: 4-168
Range on HMM: 40-218/255.0
TVRDFWKMMVDYKVSTIVMLCGDED----CCYQYWTGSKTH----GEFSVEVNNERSANGYTERNLKLSFD--KETRSVLQFQVTDWPQDGVVRKAGTIL
||  |....|  | ...||||  ..     | .|.   |       . .| . .  .      ... . .   |.|. |  .. . |..    . |  ||
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QVINDVRNRqKrgPVVVHCSDTVSRSGVYCSVSIALEQCI------KEGVVDVFQVTKTVRRSKPGAVTTQEQYD-SIYDII
...  ||.  |  .||||||  . ||  .  . ..  . |      . . .|  .. . .| ....|. |  |   ||. ..
nilkvvrds.k..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 5-161 4.6e-13 43.3 In-house 104-277 (302) alignment 
Range on Protein: 5-161
Range on HMM: 104-277/302.0
VRDFWKMMVDYKVSTIVMLCG----DEDCCYQYWT----GSKTHGEFSVEVN-NERSANGYTER-----------NLKL-SFDKETRSVLQFqvTDWPQD
.  .| .. .|.|. .| ||.    .|  | .|..    |  . |...|.    .   . .|..           | |  .  | | ..|.|  . ||. 
lekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf..sawpdh

GVVRKAGTILQVINDVRNRQKrgPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQY
|  ..| | |....     .|   |.||||  | |.|   ..   .. | |. | |. .. . ||. . ||| ...| 
Gapkeaytaldilkfcesykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
0036282 (Phosphotyrosine protein) phosphatases II 6-166 1.1e-26 89.0 In-house 27-164 (174) alignment 
Range on Protein: 6-166
Range on HMM: 27-164/174.0
RdFWKMMVDYKVSTIVMLCGDED----CCYQYWTGskthgefsvevnnersangyternlklSFDKETRSVLQFQVTDWPQDGVVRKAGtILQVINDVRN
. ||.|. .....|.|||.  .      |..||                               . ..|...|.. . || .||   .  .|.... |..
a.fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlgiqylylpwpDhgvpdlsi.llefvkfvee

RQKR---GPVVVHCSDTVSRSGVYCSVSIALEQCIkEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
 ...   |||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.|..||  .|.
alsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 6-167 3.6e-22 74.0 In-house 23-148 (151) alignment 
Range on Protein: 6-167
Range on HMM: 23-148/151.0
RDFWKMMVDYKVSTIVMLCGDE--DCCYQYWTGSKthgefsvevnnersangyternlklsfdketRSVLQFQVTDWPQDGVVRKAGTILQVINDVRNrQ
 ||.... .....|||.|...|  . |..|..                                  . ||.....|||  |.     ..|.... ... .
adflellkelgiktivnlrseeergycpeylpelg...............................ievlhipildwpdpglplsfdavleflellld.k

KRGPVVVHCSDTVSRSGVYCSVSIALEQcikegvVDVFQVTKTVRRSKPGAVTTQEQYDSIYDI
| |||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  ..  
kngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0044763 (Phosphotyrosine protein) phosphatases II 7-170 1.7e-18 62.3 In-house 39-169 (178) alignment 
Range on Protein: 7-170
Range on HMM: 39-169/178.0
DFWKMMVDYKVSTIVMLCGDEDCC----YQYWTGSKThgefsvevnnersangyternlklsfdketRSVLQFQVTDWPQDGVVRKAGTILQVINDVRNr
|..... ......||.|...  .     ..||  .                                  .|.. . |..   . .    ... |..... 
ddlellkelgithivnlteelelgflkcdpywpeeag..............................iqylhipipDhgvpdllehflefvefieeald.

QKRGPVVVHCSDTVSRSGVYCSVSIALEQcikeGVvDVFQVTKTVRRSKPgAVTTQEQYDSIYDIIDL
.| |||.||||  |.|||. .   . ...    |. ..... . ||. .| .|....|.  .|..   
ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
0048179 (Phosphotyrosine protein) phosphatases II 11-166 9.8e-16 53.3 In-house 24-139 (144) alignment 
Range on Protein: 11-166
Range on HMM: 24-139/144.0
MMVDYKVSTIVMLCGDEDCCYQYWTgskthgefsvevnnersangyternlklsfdketrsVLQFQVTDWPQDGVVRKAGTILQVINDVRNR-QKRGPVV
.. .....|.. |. . .  .   .                                    ..|.. ..||  ||   .  .|.... ...  .. |||.
llkklgittvinlteeyepeflere....................................giqylhlpwpDhgvpdllellleflefieealeeggpvl

VHCSDTVSRSGVYCSVSIALeqciKEGvVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
||||  |.|.|...   . .    |.| ...... . ||.  ||||....|.  ...
VHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 11-172 2e-06 20.7 In-house 149-309 (346) alignment 
Range on Protein: 11-172
Range on HMM: 149-309/346.0
MMVDYKV-STIVMLCGDEDCCYQYwTGSKTHGEFSVEVNNErsangYTERNLKLSFDKETRSVLQ--FQVTDWPQDGVVRKAGTILQVINDVRNRQKRGP
|. | |.  |   |  ||.  ||| ||     .   .|  .       |  ...  . .. ||.    . . | .     |.  |...| .    ..   
mvpddklkntttslfndenggyqy.tgkmfinnrradvsgd.....pkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqn

VVVhCSDTVSRSGVYCS---VSIALEQcIKEGV-VDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
. | |  ..  .|  ||      |..| . .|.  ..... |.... .||.| .  || ||| |.  |.
agv.cvvslfgcgracsfigalyainq.lnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
0048076 (Phosphotyrosine protein) phosphatases II 51-169 2.5e-17 58.4 In-house 26-140 (145) alignment 
Range on Protein: 51-169
Range on HMM: 26-140/145.0
RSANGYTERNLKLSFDKETRSVLQFQVTDWPQDGVVRKAGTILQVINDVRNRQKRG-PVVVHCSDTVSRSGVYCsvsiALEQCIKEGvVDVFQVTKTVRR
.. . .|  ||   .. ..| ..|.. ..||  ||   . ..|.... ... .|.| ||.||||  |.|.|...    |.  ....| |..... . ||.
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrs

SKPGAVTTQEQYDSIYDIID
  ||||....|.  .|. . 
qrpgavpnpgqlrflyefel
PTPc_motif_SM00404 54-124 2.5e-06 22.4 In-house 41-99 (140) alignment 
Range on Protein: 54-124
Range on HMM: 41-99/140.0
NgyternlklsFDKETRSVLQFQVTDWPQDGVVRKAGTILQVINDVrnRQKRGPVVVHCSDTVSRSGVYCS
.            .. . .|| .. |  .| ....   .|..|...  ..|.| |.|||   ||||.  . 
t..........kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatlii
DSPc Dual specificity phosphatase, catalytic domain 63-122 3.7e-06 21.8 Pfam-A 33-90 (133) alignment 
Range on Protein: 63-122
Range on HMM: 33-90/133.0
LSFDKETRSVLQFQVTDWPQDGVVRKAGTILQVINDVrnRQKRGPVVVHCSDTVSRSGVY
 .. |. .  |. .| |  .. ....   . ..|...  .||.. |.|||   .|||.  
naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatl
DSPc Dual specificity phosphatase, catalytic domain 63-122 3.7e-06 21.8 In-house 33-90 (133) alignment 
Range on Protein: 63-122
Range on HMM: 33-90/133.0
LSFDKETRSVLQFQVTDWPQDGVVRKAGTILQVINDVrnRQKRGPVVVHCSDTVSRSGVY
 .. |. .  |. .| |  .. ....   . ..|...  .||.. |.|||   .|||.  
naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatl
subfamily_DSP12_pd Subfamily DSP12 66-123 1.3e-07 26.2 In-house 45-100 (155) alignment 
Range on Protein: 66-123
Range on HMM: 45-100/155.0
DKETRSVLQFQVTDWPQDGVVRKAGTILQVINDVRnrQKRGPVVVHCSDTVSRSGVYC
.| . | .. |..| |.  ...   .... |.. .  ...| |.|||   ||||   .
kkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 69-132 2.7e-06 21.4 In-house 214-289 (350) alignment 
Range on Protein: 69-132
Range on HMM: 214-289/350.0
TRSVLQFQVTDWPQDGVVRKAGTILQVIN------D------VRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQC
   |.|.||  |.  ... .   |||...      |        . ..  |..||||  | | |.....   |.. 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf
subfamily_DSP19_pd Subfamily DSP19 71-152 3.1e-07 24.9 In-house 57-131 (152) alignment 
Range on Protein: 71-152
Range on HMM: 57-131/152.0
SVLQFQVTDWPQDGVVRKAGTILQVINDVRNRQkrGPVVVHCSDTVSRSgvycsVSIALEQCIKEGVVDVFQVTKTVRRSKP
 .|. .. | |.  ...   ..|. |...|. .  | |.|||.  ||||     .|...   .|.  ... .  ..||  .|
tylsieilDlpetdllsylkealdFieearskd..gavlvHCnAGvSRs.....asvviaylmkkeelsleealelvrearp
PTPc_DSPc_SM00012 72-168 8e-26 85.7 In-house 2-103 (105) alignment 
Range on Protein: 72-168
Range on HMM: 2-103/105.0
VLQFQVTDWPQDGVVRKAGTILQVINDVRNRQK----RGPVVVHCSDTVSRSGVYCSVSIALEQCIKE-GVVDVFQVTKTVRRSKPGAVTTQEQYDSIYD
| ....|.||. || ...  ||.....|.. ..    ..|||||||. |.|.|... ..|.|.|. || . ||.||. | .|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

II
..
al
subfamily_DSP1_pd Subfamily DSP1 74-148 2.8e-06 21.5 In-house 66-136 (163) alignment 
Range on Protein: 74-148
Range on HMM: 66-136/163.0
QFQVTDWPQDGVVRKAGTILQVINDVRNrqKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKegVVDVFQVTKTVR
. .. | |.. .     .... |..|..  |.| | .||   .|||   | . .  .. ..  . . |. .| .|
klkleDspkadislvfeeviefidevkk..knGkvlihCqaGisRsstlclaylmktkrvs..leeafdfvkqrR
subfamily_DSP23_pd Subfamily DSP23 91-171 5.7e-06 21.1 In-house 72-145 (148) alignment 
Range on Protein: 91-171
Range on HMM: 72-145/148.0
TILQVINDVRNRQKrgPVVVHCSDTVSRSGVYCSVSIaleqcIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLY
 ...|...  ....   | |||     |.|   .  .     .||  .   .    ||| .||.| | || . ..|   ..
efvrvveeaeekne..avsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi
subfamily_CG42327_pd Subfamily CG42327 101-172 5.8e-14 46.5 In-house 243-315 (319) alignment 
Range on Protein: 101-172
Range on HMM: 243-315/319.0
NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKE-GVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDIIDLYV
.|...||.|||||| | |.|.  .  ||...  .    ||. |.   ||| .  || |.|||. || ..  | 
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 101-168 6e-09 30.2 In-house 224-291 (297) alignment 
Range on Protein: 101-168
Range on HMM: 224-291/297.0
NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDII
.  .  ...||||  | ||||     . |..  |. . ||  . . .|  ..  | | ||.. .||..
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 109-167 5e-07 24.0 In-house 2-60 (69) alignment 
Range on Protein: 109-167
Range on HMM: 2-60/69.0
VVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDI
|||||    |.| . .. . . .   | .||.|   . .|. .|  |  . .|  |.| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 109-167 1.2e-06 22.7 In-house 1-59 (69) alignment 
Range on Protein: 109-167
Range on HMM: 1-59/69.0
VVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTQEQYDSIYDI
|||||    |.| . .. . . .   | .||.|   . .|. .|  |  ...|  |.| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda