Gene PTPRD-41 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP097_AA protein Get Run
AqueP097_AA_0-163 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-166 3.5e-78 257.8 In-house 108-287 (305) alignment 
Range on Protein: 1-166
Range on HMM: 108-287/305.0
MIVDCKVSTIVMLC----GDEDCCYQYWTGSMRH----GEFSVEVNNKRSANGYTERNLKLSF---DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEV
.||..||||||||.    |..|.|.|||..|...    ||||||......|..|.||.||.|.   |||||.|||.|.||||..||...|...|..|..|
liveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

RNRQKRG---PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTTN
...||..   |..||||..|.|.||...|.||||.. ||.|||||.|.|..|......|.| .||....|..|..|....
qkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-165 7.3e-70 230.0 In-house 104-296 (301) alignment 
Range on Protein: 1-165
Range on HMM: 104-296/301.0
MIVDCKVSTIVMLCGDEDC----CYQYWTG----SMRHGEFSVEVNNKR-----------------SANGYTERNLKLSFDKESRNVLQFQVTDWPQDGV
.|.. |...|||... ...    |.|||      | . |.|.|...|.                  | |||.||..| . ||.|..|||.||||||||||
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

VRKAGTILQVINEVRNRQK---RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
||   |.||||..|  ||.    ||||||||||||||||||||||.||||  |||||||||||.||||||||||| ||| ||||.|| |.|  
vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-165 9.7e-49 160.8 In-house 110-286 (290) alignment 
Range on Protein: 1-165
Range on HMM: 110-286/290.0
MIVDCKVSTIVMLCG----DEDCCYQYWTGS--MRHGEFSVEVNNKRSANGYTERNLKLSFDKE---SRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN
.|.. ||. ||||.     ... |.|||. |   . ||||....| .. |.|.||.|..  ...   ...| |.|.| |...| | .  |||.||.|. .
liwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

-RQK--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
 . |  ....||||||||.||.|.|.. .....| .|||.||||| |. |  ||| |.| .||  |..|.  |... 
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-166 2.6e-47 156.2 In-house 105-282 (287) alignment 
Range on Protein: 1-166
Range on HMM: 105-282/287.0
MIVDCKVSTIVMLCG----DEDCCYQYWTGS--MRHGEFSVEVNNKRSANGYTERNLKLSFDK---ESRNVLQFQVTDWPQDGVVRKAGTILQVINEV-R
.| | .|..|||||     ||. |||||. .  .  ||...|. |.   .||.||.|..  ..   . ..| |.|.|.|.. | | .  ||| ||.|  .
liddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk

NRQKR--GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTTN
...||  ...|||||||| ||...|.. .....| .|||.||||| |  |  |||.| | |||  |.||.  |... .
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
0050432 (Phosphotyrosine protein) phosphatases II 1-164 5e-47 156.1 In-house 127-301 (308) alignment 
Range on Protein: 1-164
Range on HMM: 127-301/308.0
MIVDCKVSTIVMLCGDEDC----CYQYW-----TGSMRHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEV
|. . .|..||||.  ..     |.|||      ||...| |.|.. .  . ..|| |.|.|..  |.||| | .|. |.|| .||  ..  .|. ...|
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
|.... ||.|||||. |.|.|... . ..|||  ||| ||||.. |..|. .||.|.|||||  .|...  |...
rkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 1-162 2.7e-44 147.2 In-house 111-286 (288) alignment 
Range on Protein: 1-162
Range on HMM: 111-286/288.0
MIVDCKVSTIVMLCGDEDC----CYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLS------FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINE
|. . .|..||||.. ..     |.|||   ||. .|...|.  .  . ..|| |.|...      .|.|||.| .|..|.|| .||   .  .|. ...
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

VRNR--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
||.   .. ||||||||. |.|.|... . ..|||  |||.|||... |..|. .||.|.|||||  .|...  |.
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 1-164 4.5e-44 146.3 In-house 96-276 (284) alignment 
Range on Protein: 1-164
Range on HMM: 96-276/284.0
MIVDCKVSTIVMLCGDEDC----CYQYWT---GSMRHGEFSVEVNNKRSANGYTERNLKLSF---DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
|. . .|..||||.. ..     |.|||    .....|.|.|.. ..   ..|| |.|.|..   ..||| | .|..|.|| .||   .  .|. ...||
mvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

NRQK----RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEG---VVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
. ..     ||.|||||. |.|.|... . ..||| .|||   .|||... | .|. .||.|.|.|||  .|...  |...
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0036941 (Phosphotyrosine protein) phosphatases II 1-164 5e-43 142.9 In-house 97-279 (297) alignment 
Range on Protein: 1-164
Range on HMM: 97-279/297.0
MIVDCKVSTIVMLCGDEDC----CYQYW----TGSMRHGEFSVEVNNKRS--ANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINE
|. . .|..||||. ...     |.|||     .|. .|.|.|.. .  .   ..|| |.|....  ..||| | .|..|.|| .||   . ..|. |..
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

VRNRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCI---KEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
||...    . |||.||||. |.|||... . ..|.|     ||| ||.... |..|. .||||.|.|||  .|...  ....
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0047943 (Phosphotyrosine protein) phosphatases II 1-162 5.4e-43 142.8 In-house 96-272 (273) alignment 
Range on Protein: 1-162
Range on HMM: 96-272/273.0
MIVDCKVSTIVMLCGDEDC----CYQYWTG-----SMRHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEV
|. . .|..||||. ...     |.|||       |...|.|.|.. .  . ..|| |.|.|..  ..||| | .|..|.|| .||      .|. |..|
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

RNRQK----RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
|. ..     ||||||||. |.|.|... . ..|.| .||| |||... | .|. .||.|.|||||  .|...  |.
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 1-164 1e-42 142.0 In-house 120-291 (297) alignment 
Range on Protein: 1-164
Range on HMM: 120-291/297.0
MIVDCKVSTIVMLCGDEDC---CYQYW--TGSmRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQ--
|. . .|..||||.  ...   |.|||  .|. ..|.|.|.. .    .||| |.|... ..||| | .||.|.|| .||   . ..|.....||...  
mvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
  | |||.||||. |.|.|...   ..|||. ||| |||... |..|. .||||.||.||  .||..  ....
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
Y_phosphatase Protein-tyrosine phosphatase 1-158 2.2e-42 140.5 Pfam-A 61-233 (235) alignment 
Range on Protein: 1-158
Range on HMM: 61-233/235.0
MIVDCKVSTIVMLCGDEDC----CYQYWT----GSMRHGEFSVEVN-NKR-SANGYTERNLKLSFDKES---RNVLQFQVTDWPQDGVVRKAGTILQVIN
|... ||..||||. .|.     | |||     .|...|...||.  ..    ..|| |.|.|. .||.   | | |...|.||. || ...  .|..|.
mvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlir

EVRNRQ--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
.|....  |.||||||||. |.|.|......|.|||. .|. |||.|. |..|...||.|.. |||  .|..|
kvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1-158 2.2e-42 140.5 In-house 61-233 (235) alignment 
Range on Protein: 1-158
Range on HMM: 61-233/235.0
MIVDCKVSTIVMLCGDEDC----CYQYWT----GSMRHGEFSVEVN-NKR-SANGYTERNLKLSFDKES---RNVLQFQVTDWPQDGVVRKAGTILQVIN
|... ||..||||. .|.     | |||     .|...|...||.  ..    ..|| |.|.|. .||.   | | |...|.||. || ...  .|..|.
mvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlir

EVRNRQ--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
.|....  |.||||||||. |.|.|......|.|||. .|. |||.|. |..|...||.|.. |||  .|..|
kvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRD_pd Subfamily PTPRD 1-166 4.1e-42 139.5 In-house 110-285 (564) alignment 
Range on Protein: 1-166
Range on HMM: 110-285/564.0
MIVDCKVSTIVMLCGDE----DCCYQYWTGS--MRHGEFSVEVNNKRSANGYTERNLKL--SFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR
|. . ..||||||   |    . | .||  .   ..||. |.....   . |. |..||  . ..|||.| ||. |.||. ||  .| ..|..|..||. 
mvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvral

--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTTN
  ...||.|||||  | |.|... ... ||.  .|..||..|. |..|. ..  | |.|||  |...|  ...  |
nepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
0040438 (Phosphotyrosine protein) phosphatases II 1-164 6e-42 139.4 In-house 105-278 (317) alignment 
Range on Protein: 1-164
Range on HMM: 105-278/317.0
MIVDCKVSTIVMLCGDEDC----CYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR
|. . .|..||||.  |..    |.|||   ... .|.|.|.. .    .|.| |.|...   |.||| | .|. |.|| .||     ..|. ...||. 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
  .. |||.||||. |.|.|... . ..|||. ||| |||... |..|. .||||.|||||  .||..  |...
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
DSPc_SM00195 1-162 1.5e-41 137.9 In-house 88-262 (263) alignment 
Range on Protein: 1-162
Range on HMM: 88-262/263.0
MIVDCKVSTIVMLCGDEDC----CYQYWTGS----MRHGEFSVEVNNKRSAN-GYTERNLKLSFDK--ESRNVLQFQVTDWPQDGVVRKAGTILQVINEV
|... ||..||||. .|..    |..||  .    ...|..||.. .. . .  .. |.|.|....  |.|.| |.|...||. ||  ..  .|.....|
mvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellrav

RNRQK--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
.....   ||.|||||. |.|.|......|.|... .|  ||.|.. | .| ..||.|.| |||  ||..|  ||
kkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-162 1.5e-41 137.9 In-house 88-262 (263) alignment 
Range on Protein: 1-162
Range on HMM: 88-262/263.0
MIVDCKVSTIVMLCGDEDC----CYQYWTGS----MRHGEFSVEVNNKRSAN-GYTERNLKLSFDK--ESRNVLQFQVTDWPQDGVVRKAGTILQVINEV
|... ||..||||. .|..    |..||  .    ...|..||.. .. . .  .. |.|.|....  |.|.| |.|...||. ||  ..  .|.....|
mvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellrav

RNRQK--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
.....   ||.|||||. |.|.|......|.|... .|  ||.|.. | .| ..||.|.| |||  ||..|  ||
kkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-166 3.9e-40 133.0 In-house 118-294 (298) alignment 
Range on Protein: 1-166
Range on HMM: 118-294/298.0
MIVDCKVSTIVMLCGDED----CCYQYWTG--SMRHGEFSVEVNNKRSANGYTERNLKLSFDK--ESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR
|... ...|||||   |.     . .||    . ..||..|.. .| .   .. |.||.|  |  ..|.| |...| ||. || ..| ..|.....||  
mvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

Q-KRG--PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTTN
| . |  ||.|.||. | ||| .. ..  ||.  || ||||||| |..|...||||.| |||  ||...  .... |
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0043336 (Phosphotyrosine protein) phosphatases II 1-162 5.8e-40 132.9 In-house 107-277 (278) alignment 
Range on Protein: 1-162
Range on HMM: 107-277/278.0
MIVDCKVSTIVMLCGDEDC----CYQYW-TGSMRHGEFSVEVNNKRSANGYTERNLKLS--FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR-
|. . .|.|||||.....     |.|||  ||...|.|.|.. .  . ..|| |.|...   |.||| |.... ..|| .||     ..|. ...||.. 
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

-QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
  . |||.||||. |.|.|... . ..|||  ||| ||.... |..|. .||||.||.||  .|...  |.
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-165 5.9e-40 132.3 In-house 110-286 (319) alignment 
Range on Protein: 1-165
Range on HMM: 110-286/319.0
MIVDCKVSTIVMLCGDED----CCYQYWTGSM--RHGEFSVEVNNKRSANGYTERNLKL---SFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN
|. . ..|..|||... .     . .||.     . |.. |......  ..|  |.|||   | . |.|.| .|| |.||...| .|| ..|......|.
mvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

RQKR---GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
 ...   ||.|||||. | | | .. ....||.  .|||.|||.. ...|  ..  | .||||  ||...  .... 
srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
0040439 (Phosphotyrosine protein) phosphatases II 1-162 7.9e-40 132.4 In-house 73-246 (249) alignment 
Range on Protein: 1-162
Range on HMM: 73-246/249.0
MIVDCKVSTIVMLCGDEDC----CYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLS--FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR
|. . ....||||. .. .    |.|||   ||. .|.|.|.. .  . ..|| |.|.|.   |.||| ||..|.|||| .||     ..|. |..||. 
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

Q----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
.    | |||.||||. |.|.|...   ..|||  ||. ||.... |..|. .||||..||||  .|...  ..
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 1-162 2.4e-39 131.3 In-house 126-304 (307) alignment 
Range on Protein: 1-162
Range on HMM: 126-304/307.0
MIVDCKVSTIVMLCGDEDC----CYQYW---TGSMRHGEFSVEVNNKRSANGYTERNLKLS---FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
|. . .|..||||......    |.|||    ... .|.| |.. ..   .||| |.|...   ...||| | .|. |.|| .||     ..|. |.|||
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

NRQ----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
. .    | |||.||||. |.|.|...   ..|.|  |||.   ||.... |..|. .||||..||||  .|...  ..
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-165 5.6e-39 128.8 In-house 71-245 (250) alignment 
Range on Protein: 1-165
Range on HMM: 71-245/250.0
MIVDCKVSTIVMLCG---DEDCCYQYWT--GSMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRN--VLQFQVTDWPQDGVVRKAGTILQVINEVRNRQ
|... |..|||||      |  . |||   .. ..|.  |.. .|     || |.||||  |.. .  | |.. . ||  || ..| ..|.....|.  |
mvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasq

KR---GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
..   .||.|.||  |.||| .. ..  ||.  || |||||.| |..|. .|.||.. ||| ..| ||  .....
qqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0042113 (Phosphotyrosine protein) phosphatases II 1-161 1.6e-37 124.6 In-house 71-242 (245) alignment 
Range on Protein: 1-161
Range on HMM: 71-242/245.0
MIVDCKVSTIVMLCGDEDC----CYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLS--FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN-
|. . ...|||||. .|.     |.|||   .|...|.|.|.. .  . ..|| |.|...   |.|||.|.... ..|| .||     ..|.....||. 
mlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrka

--RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLY
  . . |||.||||. |.|.|... . ..|||  ||. |..... | .|. .||||.||.||  .|...  .
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-164 1.1e-36 121.5 In-house 108-282 (318) alignment 
Range on Protein: 1-164
Range on HMM: 108-282/318.0
MIVDCKVSTIVMLCGDED----CCYQYWT--GSMRHGEFSVEVNNKRSANGYTERNLKLSFD--KESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR
|. . . ..||||   |.     . .||   ||. .|.  ||.... . . |. |..|.. .  .|||.| |...|.||. ||  .....|... .|.. 
mvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

Q---KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
|   ..||.|||||  | | ||.. |.| ||.  .|..|||||. |..|. ..  | | .||. |||..  ....
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0037934 (Phosphotyrosine protein) phosphatases II 1-161 3.1e-36 120.5 In-house 67-241 (243) alignment 
Range on Protein: 1-161
Range on HMM: 67-241/243.0
MIVDCKVSTIVMLCGDE----DCCYQYWTGSMRHGEFSVEVNNKRSANGYTERNLKLSF---DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR---
|. . ....||||. ..      |.||| |....|.|.|.. . .. ..|| |.|.|.    |...|.| ... . ||  ||      .|. ..|||   
mlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefi

-------NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCikeGvVDVFQVTKTVRRSKPG-AVTTPEQYDSIYDIIDLY
       .. . |||.||||  |.|.|...   . |...   | ||.... |..|. .|| ||.||.||  .|...  .
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-163 2.2e-35 117.0 In-house 106-278 (315) alignment 
Range on Protein: 1-163
Range on HMM: 106-278/315.0
MIVDCKVSTIVMLC----GDEDCCYQYWTG----SMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR--
|... ||.||||.     ||   | |||      |.. |...||. .  .  . . |.| .   .|||.| ||| |.||. || ......|..| ||.  
mvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad

NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
|..|  ...||||  | |.|| .|.   ..|  .. .||||.. |..|. .|  | | |.|  |||..  ...
ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0045098 (Phosphotyrosine protein) phosphatases II 1-163 5.4e-34 113.2 In-house 83-273 (278) alignment 
Range on Protein: 1-163
Range on HMM: 83-273/278.0
MIVDCKVSTIVMLCGDEDC----CYQYWTG--SMRHGEFSVEVNNKRSANGYTERNLKLS------FDKESRNVLQFQVTDWPQDGVVRKA--GTILQVI
|. . ....||||.. ..     |.|||    |...|.|.|.. .    . || | |..        | |||.| ... . ||  ||        .|...
mlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflell

NEVRNRQ---------------KRGPVVVHCSDTVSRSGVYCSVSIALEQCikEGVVDVFQVTKTVRRSKPG-AVTTPEQYDSIYDIIDLYIQ
...|...               . |||.||||  |.|.|... . . ||..  ||.||.... |..|. .|| ||...|||  .|. . ....
efirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-164 8.8e-34 112.0 In-house 111-286 (297) alignment 
Range on Protein: 1-164
Range on HMM: 111-286/297.0
MIVDCKVSTIVMLCGDED---CCYQYWT--GSMRHGEFSVEVNNKRSANGYTERNLKLSFDK--ESRNVLQFQVTDWPQDGVVR--KAGTILQVINEVRN
|..| .|||||||  |..    | .||.  |..  |. ||...   . .|. .|.|... .|    | | |.| ..||.. | |  .| ..|..|.|||.
mvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrk

R---QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
    .. ||..|||.  | | ||....   . .  .|  ||.|.. | .|...|  | | |||  .| ..  .. .
dfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-163 1.2e-32 107.7 In-house 105-277 (515) alignment 
Range on Protein: 1-163
Range on HMM: 105-277/515.0
MIVDCKVSTIVMLC----GDEDCCYQYWTG----SMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR
.... .|.||.|.     ||   | .||      |.. |...||.    .  | . |.|..  ...|| | ||. |.||. || ... ..|..| ||.  
lvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkad

--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
  |   |...|||  | | ||..|.   . .  .  .||||.. . .|. .|  | | |||  ||...  .. 
hgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN12_pd Subfamily PTPN12 1-163 1.4e-32 107.7 In-house 102-278 (290) alignment 
Range on Protein: 1-163
Range on HMM: 102-278/290.0
MIVDCKVSTIVMLCG----DEDCCYQYWTGS----MRHGEFSVEVNNKRSA-NGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN
|| ...|. .||.|     .   | .||. .    ...|||.|......   .... | ||. ..||||.| ||. |.||  || ..| ..|..|..||.
miweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvre

RQKR--GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
.|..   |.|||||  | | |. ... .. |.  .| .   .|||..  ..|. .. .| | |||  .|  .  ..|
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Ptp69D_pd Subfamily Ptp69D 1-165 3.1e-32 106.9 In-house 110-289 (307) alignment 
Range on Protein: 1-165
Range on HMM: 110-289/307.0
MIVDCKVSTIVMLCGDEDC----CYQYWT--GSMRHGEFSVEVNNKRSANGYTERNLKLSFDK-------ESRNVLQFQVTDWPQDGVVRKAGTILQVIN
|| . .| .||||   ..     | .||.    ...|.  |.. ...... |..|.|..|  |       .||.|.|.. | |.   | . | ..|..|.
miaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVR--NRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
.||  ....|.|.|||||  |.|||.. .... |.|. .|  ||.|...| .|. ..  |.  |||  .|  .  |.. .
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_CG7180_pd Subfamily CG7180 1-163 3.2e-32 106.4 In-house 104-291 (296) alignment 
Range on Protein: 1-163
Range on HMM: 104-291/296.0
MIVDCKVSTIVMLCGDED---CCYQYWTGS--MRHGEFSVEVNNKRSANGYTERNLKLSFD------------KESRNVLQFQVTDWPQ-DGVVRKAGTI
.. | ..|..|.|.   |    . .||      ..||. ||. ....    . |..||                | | |..||.| |.  | |   . ..
lvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnal

LQVINEVRN---R----QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
..... ||    .    ...|||||..|| .||||||... ..||. .||. ||||.  ||.|||.|. | . |.|  |||..  .. 
ielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPRA_pd Subfamily PTPRA 1-161 6.7e-32 105.7 In-house 120-294 (330) alignment 
Range on Protein: 1-161
Range on HMM: 120-294/330.0
MIVDCKVSTIVMLCG----DEDCCYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLS------FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINE
|| . | .|||||      .|. |.|||   |.. .|.  |||...  .. || |.. .        .|.|| | ||  | ||. ||  ..  .|.....
miweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk

VRN--RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLY
|..  .|. ||.|||||  | |.| .. ..  ||.   |..||||.. | .|  .|  | | |||  || ..  |
vkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-158 5e-31 102.6 In-house 94-262 (283) alignment 
Range on Protein: 1-158
Range on HMM: 94-262/283.0
MIVDCKVSTIVMLC----GDEDCCYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRN---VLQFQVTDWPQDGVVRKAGTI--LQVINEV
|. | |...||||     . .  | |||   ||. .||| | ...  . | .. ..| |  .  ...   .  .|| || . |      ..  .  .   
mvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl

RNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
....|.||.||||| .. |..|....| ....   | |||||.| | .|  ...|| | .||  .....
qteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-158 7.3e-31 102.2 In-house 111-275 (315) alignment 
Range on Protein: 1-158
Range on HMM: 111-275/315.0
MIVDCKVSTIVMLC----GDEDCCYQYWTG-SMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN--RQ
.. . ....||||     |..  . .||    . .|...|   ..   . || | |   |... |.|.|...| ||. || . . .....|  |.    .
lvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtn

KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
. |..|||||. | |.| .....  |.|   | ..||... . ||. . ..| . |||. |||..
svgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_PTPRK_pd Subfamily PTPRK 1-158 1.7e-30 101.0 In-house 105-273 (314) alignment 
Range on Protein: 1-158
Range on HMM: 105-273/314.0
MIVDCKVSTIVMLCG-DEDC---CYQYWTG-SMRHGEFSVEVNNKRSANGYTERNLKLSF----DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN
.. | . ..||||    |     |..||   .. .|.. ||. .    . .  | ....      .| | | ||| . ||. .|  .| ..|... .| .
lvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk

R--QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
   .. |..|||||    |.|... ..| |.   .|||||||.. ||.| .|.  | | |||  |||.|
sqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRG_pd Subfamily PTPRG 1-165 3.9e-30 99.6 In-house 110-290 (563) alignment 
Range on Protein: 1-165
Range on HMM: 110-290/563.0
MIVDCKVSTIVMLCG----DEDCCYQYW--TGSMRHGEFSVEVNNKRSANGYTERNLKLSF------DK--ESRNVLQFQVTDWPQDGVVRKAGTILQVI
|| . .|..|||.          | .||   .|.. |...|   ..     ||.|.|..        ..  . ..| |.. |.||. ||  ..   |. .
miWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifv

N--EVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
.  .  |... ||.|||||  |.|.|.|. ..  |.|  .| .|.||.. |..|  ..  |.| |||  ..|..   |.. 
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-165 4.7e-30 99.6 In-house 92-271 (274) alignment 
Range on Protein: 1-165
Range on HMM: 92-271/274.0
MIVDCKVSTIVMLCG----DEDCCYQYWTGSM------RHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
||   .|. ||||      .|. | .|.  .       |.|.....|... . |.|. |.| |.  ...|.|  .  ||||   . ..| |.|....||.
miyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleve

NRQ-----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
. .     |..|||||||  . | |.. ..|||. |  .|.||||....  .|  . | | | |||. |. .. || . .
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-159 6.5e-30 99.2 In-house 109-276 (288) alignment 
Range on Protein: 1-159
Range on HMM: 109-276/288.0
MIVDCKVSTIVMLC----GDEDCCYQYWTGSM---RHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQ
.. . |.||||||     |..  | .||  .    ..|.. |.. ...  . ...|.| |  .|. ... |.| . ||..|| . .  .|.... | . .
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan

--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIID
  . ||..||||. | |.|.. ..  ....  .| ..||. . . .|....  | | .||  ||... 
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRB_pd Subfamily PTPRB 1-163 1.2e-28 95.0 In-house 113-286 (293) alignment 
Range on Protein: 1-163
Range on HMM: 113-286/293.0
MIVDCKVSTIVMLCG----DEDCCYQYWTGS---MRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQ
|. . |.|.||||          | .||      . .|. .|....... . .. |.||.. .||.|.| |.. | ||. ||  |. |.|. ...||...
mvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

----KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
    ...|.|||||  | |.|.. ..   |..  .| .||.| .   .|...   | | .||  |.. .  ...
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-165 1.5e-28 94.6 In-house 83-267 (270) alignment 
Range on Protein: 1-165
Range on HMM: 83-267/270.0
MIVDCKVSTIVMLCG----DEDCCYQYWTG------SMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAG------TILQ
||.. ||..|||. |      . | .||.       ....|. .| . ... ..||  ..|.|  . |.|... |. ..||..||.|...       .|.
miweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllk

VINEV---RNRQKRG-PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
....|   ....... |..||||. | |.|.   . ||..   ... ||| .. . .|. ..  | .||||  .|  . .|....
mlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-156 1.5e-26 88.5 In-house 123-285 (319) alignment 
Range on Protein: 1-156
Range on HMM: 123-285/319.0
MIVDCKVSTIVMLCgdEDCCYQYWT--GSMRHGEFSVEVNNKRSANGYTERNLKLSF---DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR----N
|| . ..||||.|   .| | |||   . .....| |.|.    .. |. |...||     |. |.. ||    ||. ||   .  ...... ||     
miweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
 ..| ..|||||  | |.|||  . . |..  .|  |||... . .|. ..  |    ||  || 
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-156 2.2e-26 88.0 In-house 87-249 (284) alignment 
Range on Protein: 1-156
Range on HMM: 87-249/284.0
MIVDCKVSTIVMLCgdEDCCYQYWT--GSMRHGEFSVEVNNKRSANGYTERNLKLSF---DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR----N
|| . ..||||.|   .| | |||   . .....| |.|.    .. |. |...||     |. |.. ||    ||. ||   .  ...... ||     
miweyncstivllt..kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk

RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
 ..| ..|||||  | |.|||  . . |..  .|  |||... . .|. ..  |    ||  || 
enhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_PTPN3_pd Subfamily PTPN3 1-158 5.9e-26 86.0 In-house 103-271 (280) alignment 
Range on Protein: 1-158
Range on HMM: 103-271/280.0
MIVDCKVSTIVMLCGD----EDCCYQYWT---GSMRHGEFSVEVNNKRSANGYTERNLKLSFDK--ESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN
|. . |.|.||||          |.|||     ....|||||....... . |  |.| |.  .  |.|..||.| ..||. ||  ..  .|.....||.
mvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrk

RQ--KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
 .  |. |||||||  . |.||.  . .||    ..  | . .. .|.|  .   | |..||  . . |
lrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-161 1.5e-25 85.0 In-house 110-287 (325) alignment 
Range on Protein: 1-161
Range on HMM: 110-287/325.0
MIVDCKVSTIVML---CGDEDCCYQYWTGS----MRHGEFSVEVNNKRSANGYTERNLKLSFDK--ESRNVLQFQVTDWPQDGVVRKAGTI---LQVINE
...| . | .|.|    ...| | .||        . | . |..        |  | |..   |  |.| | |||.  |.. || ..  |.   ||....
lvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

VRNR-----QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLY
| .|     .  .|..||||. | |.||. |.  ||.. |.|  ||.|.. | .|. .|  | | .||  ||. .  .
vservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-164 4.3e-25 83.4 In-house 103-278 (281) alignment 
Range on Protein: 1-164
Range on HMM: 103-278/281.0
MIVDCKVSTIVMLCGD----EDCCYQYWTGS---MRHGEFSVEVNNKRSANGYTERNLKL-SFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN-
|... |||.|||.  .       |..||      .. |.. |. ..... . | ||..||   . |.|.| |.. | ||. ||  ..  .|.  .||.. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

--RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKE-GVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQT
  ...  |.|.|||  | |.|.| ..  ..... .|   .|| .| . .|...   | |  ||. .| ..  ... 
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN23_pd Subfamily PTPN23 1-163 6.9e-25 82.4 In-house 102-281 (288) alignment 
Range on Protein: 1-163
Range on HMM: 102-281/288.0
MIVDCKVSTIVMLCGDEDC----CYQYWT----GSMRHGEFSVEVNNKRSANGYTERNLKLSFDKE--SRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
|... |.|.||||   |.     . .||      ....|..|| ....|... . ||.|||.. ..   ..|   |.| ||. ||    .|.||...||.
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

N------RQKRGPVVVHCSDTVSRSGVYCSVSIALEQC-IKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
.      |. . |.|||||  | |.||.. |  |...   ..|..|. || ...|. .   | . ||.   |...  ...
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
0041856 (Phosphotyrosine protein) phosphatases II 1-162 1.6e-24 81.9 In-house 53-171 (182) alignment 
Range on Protein: 1-162
Range on HMM: 53-171/182.0
MIVDCKVSTIVMLCgdedcCYQYWTgsmrhgefsvevnnkrsangyternlklsfDKESRNVLQFQVTDWPQDGVVRkAGTILQVINEVRNrqKRGPVVV
|. . ...|||.|.     ...||                               ... |...|.. . || .||     ..|. |.||..  . |||.|
mlkelgittivnlt.....eelywp..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlV

HCSDTVSRSGVYCSVSIALEQcikeGvVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
|||  |.|.|...   . ...    | |..... |.||. .||.|.||.||  ..... ...
HCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallell
0036282 (Phosphotyrosine protein) phosphatases II 1-156 1.7e-24 81.8 In-house 31-164 (174) alignment 
Range on Protein: 1-156
Range on HMM: 31-164/174.0
MIVDCKVSTIVMLCGDED----CCYQYWTGsmrhgefsvevnnkrsangyternlklSFDKESRNVLQFQVTDWPQDGVVRKAGtILQVINEVRNRQKR-
|. . ...|.|||.  .      |..||                               . ..|...|.. . || .||   .  .|.....|.. ... 
mlkelgittvvmlleekelglykcinywpe...........................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsed

--GPVVVHCSDTVSRSGVYCSVSIALEQCIkEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
  |||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.||.||  .|.
pggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN9_pd Subfamily PTPN9 1-161 4.1e-24 80.1 In-house 104-289 (297) alignment 
Range on Protein: 1-161
Range on HMM: 104-289/297.0
MIVDCKVSTIVMLCG----DEDCCYQYWT----GSMRHGEFSVEVNNKRSANGYTERNLKLS--FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
|. . .| .|||           | |||      |...|..||.. . .. . |..| |...   ..|||.|  ||.. ||  || . | ..|.|...||
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

NRQK---------------RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLY
..|                  |.|||||  . |.| .... |.|..  ..|.|||... |..|  .  .. |||||   |  .  |
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN13_pd Subfamily PTPN13 1-158 1.4e-23 78.6 In-house 96-265 (273) alignment 
Range on Protein: 1-158
Range on HMM: 96-265/273.0
MIVDCKVSTIVMLCGDED----CCYQYWTGSMR-----HGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEV
|. . |.. |.|.  . .     | .||  |..     .. . ||. .    .|.. |.|...    .|||.| ... ..||  || ..|  .||.. ||
mvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaev

RNRQK-RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
|. |. .||.|||||  . |||.. .. ..|.   ..  .|| .. ...|. . | | | .||  .| .|
rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-158 3.5e-23 77.1 In-house 64-235 (237) alignment 
Range on Protein: 1-158
Range on HMM: 64-235/237.0
MIVDCKVSTIVMLCG----DEDCCYQYWTGS---MRHGEFSVEVNNKRSANGYTERNLKLSFD---KESRNVLQFQVTDWPQDGVVRKAGTILQ----VI
|. . | | |||| |    .|  |..||  .     .| ..| .  |     || | | ||     || | . |.| | ||. || ... ..|.    .|
mvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrknii

NEVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
|. .  .. || ..|||  | |.|..  .   | |. .. |||...  ...   .|  . | .||  |.. |
nrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-158 5.6e-22 72.8 In-house 110-275 (439) alignment 
Range on Protein: 1-158
Range on HMM: 110-275/439.0
MIVDCKVSTIVMLCGDEDcCYQYWTGS--MRHGEFSVEVNNKRSANGYTERNLKLSFD----KESRNVLQFQVTDWPQDGVVRKAGTILQV---INEVRN
.... |..|||||.   .  |.||  .  . .|. .| |. .     |. | .|.  .    .  | ||||. . ||.  |  .|  .|.    ||   .
lviekktvtivmltnlve.sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
... ||||||||  | |.|   .. |||||   |  ||.  . | .|. .   | .  ||  ||. .
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0046846 (Phosphotyrosine protein) phosphatases II 1-162 4.5e-21 70.8 In-house 42-173 (176) alignment 
Range on Protein: 1-162
Range on HMM: 42-173/176.0
MIVDCKVSTIVMLCGDEDC----CYQYWTGSMRHGEfsvevnnkrsangyternlklsfdkesrnvlQFQVTDWPQDGVVRKaGTILQVINEVRNRQKRG
|. . .....|.|. . .     |..||   ...|                                |.....||  ||      .|......|...|.|
mlkelgitavvnlteevelgrlkcpnywpeleklgi...............................qylhlpwpDhgvpdl.elllellefirealkeg

-PVVVHCSDTVSRSGVYCSVSialeQCIKEGVVDVFQVTKTVRRSKP-GAVTTPEQYDSIYDIIDLYI
 ||.||||  ..|.|...        ...|  ..|... ..||. .| |||.|||||  .|. . |..
gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 1-155 1.1e-20 69.5 In-house 39-154 (172) alignment 
Range on Protein: 1-155
Range on HMM: 39-154/172.0
MIVDCKVSTIVMLCGDedccyqywtgsmrhgefsvevnnkrsangyternlKLSFDKESRNVLQFQVTDWPQDGVVrKAGTILQVINEVRN---RQKRGP
|. . ....||.|..                                     .  ....|...|.. . ||  ||   .  .|.... ...   ... ||
mlkelgithivnltel...................................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

VVVHCSDTVSRSGVYCSVSIALeqcikeG-VvDVFQVTKTVRRSKPGAVTTPEQYDSIY
|.||||  |.|.|. .   . |        . ..... ..||. .||||..|.||  .|
vlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-158 3e-20 67.0 In-house 107-232 (392) alignment 
Range on Protein: 1-158
Range on HMM: 107-232/392.0
MIVDCKVSTIVMLCGDE--DccyqywtgsmrhgefsvevnnkrsangyternlklsFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR--QKRG
|. . .|.||.|.   .  |                                      .. | | ||..|.||...| ... ..|..|.||.    |   
mvfqenvttiamvtklkegd....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth

PVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
|...|||  | |.||  |.   . .. |  .||||..   .|| .|  | | |||  ||  .
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0051082 (Phosphotyrosine protein) phosphatases II 1-157 9.5e-20 66.2 In-house 28-148 (151) alignment 
Range on Protein: 1-157
Range on HMM: 28-148/151.0
MIVDCKVSTIVMLCGDE--DCCYQYWTGSMrhgefsvevnnkrsangyternlklsfdkesRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNrQKRGPV
.. . ...|||.|...|  . |..|..                                  ..||.....|||  |.     ..|........ .| |||
llkelgiktivnlrseeergycpeylpelg...............................ievlhipildwpdpglplsfdavleflellld.kkngpv

VVHCSDTVSRSGVYCSVSIALEQcikegvVDVFQVTKTVRRSKPGAVTTPEQYDSIYDI
.||||  ..|.|. . . . |..      |..... . .|.. ||.|....|.  ..  
lvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 1-156 1.6e-19 65.5 In-house 28-144 (152) alignment 
Range on Protein: 1-156
Range on HMM: 28-144/152.0
MIVDCKVSTIVMLCGDED----CCYQYWtgsmrhgefsvevnnkrsangyternlklsfdkesrnvlQFQVTDWPQDGVVRKAGTILQVINEVRN--RQK
|. . ...|||||. ...    .|.||.                                       |.. . || .||   .  .|...  ..   ..|
mlkelgittivmltellelgklkceqyi.......................................qylhlpwpDhgvpdlsqlllflllfieklaldk

RGPVVVHCSDTVSRSGVYCSVSIALeqcikeGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
 |||.||||  |.|.|...   . |        |..... . ||. .||||..|.|.  .|.
ggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-165 1e-17 58.9 In-house 99-280 (287) alignment 
Range on Protein: 1-165
Range on HMM: 99-280/287.0
MIVDCKVSTIVMLC-GDE---DCCYQYWTG---SMRHGEFSVEVNNK-RSANGYTERNLKLSfDKESRN---VLQFQVTDWPQDGVVRK----AGTILQV
.... ........    |     ||.||      || | .|| . ..      |. | |.|  | |.|.   | |... .||....       .  .|.|
avletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldv

---INEVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
   |.  |. .. ||.|||..  . |||.. .. . ...  . | ||| .|   .|  . . | .. |.  .|. .  | .| 
kqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_PTPN14_pd Subfamily PTPN14 1-165 1.1e-17 59.0 In-house 112-299 (300) alignment 
Range on Protein: 1-165
Range on HMM: 112-299/300.0
MIVDCKVSTIVMLCGD----EDCCYQYWTGS------MRHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINE
|. . .|. ||||  .     . ...|.  .      ...|.| |  . ..... .. . ||| .   || |.|. .| ||||..|| .   . |. ..|
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLee

V---RNR--------QKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTT
|   |..        ... ||.||||. | |.||   . . ..   .. ..|. .| ...|. .   | |  ||  .|...  |.. .
vqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-158 1.1e-16 55.7 In-house 91-255 (267) alignment 
Range on Protein: 1-158
Range on HMM: 91-255/267.0
MIVDCKVSTIVMLC-GDEDCCYQYWTGSM----RHGEFSVEVNNKRSANGYTERNLKLSFDKES-RNVLQFQVTDWPQDGVVRKAG-TILQVINEVRNRQ
.| | ||..||.|    .|   ..|   |    .. ...|| . ..  | |    |.| | .|| .||  .    |  .   .     .. .. . .  .
vihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen

KRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
   |.||.||| | ||| .  .   ||.  .|||.|.|.  . .|  ..| | | |.|  |....
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
0044763 (Phosphotyrosine protein) phosphatases II 1-160 1.7e-16 55.9 In-house 43-169 (178) alignment 
Range on Protein: 1-160
Range on HMM: 43-169/178.0
MIVDCKVSTIVMLCGDEDCC----YQYWTGSMRhgefsvevnnkrsangyternlklsfdkesRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNrQKRG
.. . ....||.|...  .     ..||  ..                                ..|.. . |..   . .    ... |.|... .| |
llkelgithivnlteelelgflkcdpywpeeag..............................iqylhipipDhgvpdllehflefvefieeald.ekgg

PVVVHCSDTVSRSGVYCSVSIALEQcikeGVvDVFQVTKTVRRSKPgAVTTPEQYDSIYDIIDL
||.||||  |.|||. .   . ...    |. ..... . ||. .| .|..|.|.  .|..   
pvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-158 8.4e-16 52.5 In-house 113-279 (290) alignment 
Range on Protein: 1-158
Range on HMM: 113-279/290.0
MIVDCKVSTIVMLCG----DEDCCYQYWTG----SMRHGEFSVEVNNKRSANGYTERNLKLSFDKES---RNVLQFQVTDWPQDGVVRKAGTILQVINEV
|... ||..|||||         | ||.       .  ||..|   .. . .  . ...    ||.|     .  ...  ||.  |   . ..|...  .
mvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril

RnrQKRGPVVVHCSDTVSRSGVYCSVSIALeQCIKEG-VVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
|  .  ||||||||  . |.| . .. ..| |.. .|  .|. .. ...|.|. ..|    ||  . .|.
r..kasGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1-159 6.1e-12 39.8 In-house 115-286 (305) alignment 
Range on Protein: 1-159
Range on HMM: 115-286/305.0
MIVDCKVSTIVMLCGDE----DCCYQYWTGSMRH------GEFSVEVNNKRSANGYTE---RNLKLSF-DKESRNVLQFQVTDWPQDGVVRKAGTILQVI
|... ||  |||||         | |||  ..        |    .|   .  .  .|     |.|..  ...  | ..| |.||. ||     | |...
mviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell

NEVRNrqKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEG-VVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIID
  .|    . |.|||||  . |.|   ..   ||.  ..  .  . .. |..|  .  .. .  ||  |. .. 
sairg..skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_egg_pd Subfamily egg 1-162 8e-11 36.2 In-house 102-270 (307) alignment 
Range on Protein: 1-162
Range on HMM: 102-270/307.0
MIVDCKVSTIVMLCG--DEDCCYQYWTG----SMRH--GEFSVEVNNKRSAN--GYTERNLKL-SFDKESRNVLQFQvTDWPQDGVVRKAgtiLQVINEV
|.   .|  ||||    . . |  ||      |..   | . .|  .  |.    ..  .|||   |.| | .  .|  |. . . |      |.|.  .
mvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysp...lrvlrkl

rnRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVV--DVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
  |.   ||||.. . ||....  .. ||| . ..  ..   | .  . .|. .. .| .. .|  .| .. ...
..rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1-161 7.5e-10 33.3 In-house 47-221 (255) alignment 
Range on Protein: 1-161
Range on HMM: 47-221/255.0
MIVDCKVSTIVMLCGDED----CCYQYWT----GSMRHGEFSVEVNNKRSANGYTERNLKLSFD--KESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
.||  | ...||||  ..     | .|.     . ..  . .| . .  .      ... . .   |. ..|  .. . |..    . |  ||...  ||
tivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvr

NRqKrgPVVVHCSDTVSRSGVYCSVSIALEQCI------KEGVVDVFQVTKTVRRSKPGAVTTPEQYD-SIYDIIDLY
.  |  .||||||  . ||  .  . ..  . |      . . .|  .. . .| ....|. || |   ||. ..||.
ds.k..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 1-164 1.5e-09 32.1 In-house 53-230 (263) alignment 
Range on Protein: 1-164
Range on HMM: 53-230/263.0
MIVDCKVSTIVMLCGDED----CCYQYWT----GSMRHGEFSVEVNNKRSANGYTERNLKLSFD--KESRNVLQFQVTDWPQDGVVRKAGTILQVINEVR
.||  | ...||||  ..     | .|.     . ..  . .| . .  |      ..|   ..  |. ..| ... . |..   ...|  ||.... .|
tivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvar

NRqKrgPVVVHCSDTVSRSGVYCSVSIALEQCI------KEGVVDVFQVTKTVRRSKPGAVTTPEQYD-SIYDIIDLYIQT
|  |  ..|||||  . ||  .  . ..  . |      . . .|  .. . .| |...|. || |   ||. ..|. .. 
ns.k..slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1-150 1.8e-09 31.8 In-house 109-269 (301) alignment 
Range on Protein: 1-150
Range on HMM: 109-269/301.0
MIVDCKVSTIVMLCGD----EDCCYQYWTGS----MRHGEFSVEVNNKRSA--NGYTERNLKLS---FDKESRNVLQFQVTDWPQDGVVRKAGTILQVIN
|.|  .| .||||.      |. | .| . .    .. | |.....|| .   .  ..|.|..     . ..| |. .| ..|.. || .    . ....
mlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme

EVRNRQKrgPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQ
 |.. .|  |.|||||. . ||  . .  .   .   .  ... .  | .|  .  .| | .|
lvkksek..PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2-157 1.1e-18 61.8 In-house 256-433 (440) alignment 
Range on Protein: 2-157
Range on HMM: 256-433/440.0
IVDCKVSTIVMLCGDED-CCYQYW---TGSMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWP----QDGVVRKA---GTILQVINEVR
. | ..|||.||   .|  |  ||   | |.  | |.|  .     |    | |.| . .|  .. ||.|  ||     |||  .     ..||... .|
vhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwiqsdgvqsqeqcmdavlqlmdylr

N-------RQKR----GPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDI
.        | |     |..|||   .  |||.|.|   |||  ..| .||||  . .| |.|  | |  .|   | .
kceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykl
subfamily_PTPRN_pd Subfamily PTPRN 2-156 6.6e-17 56.2 In-house 120-286 (297) alignment 
Range on Protein: 2-156
Range on HMM: 120-286/297.0
IVDCKVSTIVMLCGDED----CCYQYW--TGSMRHGEFSVE-VNNKRSANGYTERNLKL--SFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRN-
. .  |  ||.|.  |.     |..||  .||  .. . |. | ..  .. |  | . |     .|.| | ||    ||. ||  .| ..|.    |   
vweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks

-RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKeGV--VDVFQVTKTVRRSKPGAVTTPEQYDSIYD
 | .  |.|||||| . |.|||. . . |.. .| ||  .|.    . .|  .|| | | .|.. .. 
yrGrscpivvhcsdGaGrtGvyilidlvlnrllk.Gvkeidiaatlehlrdqrpglvktkdqfefalt
0051429 (Phosphotyrosine protein) phosphatases II 3-162 7e-25 83.6 In-house 42-225 (272) alignment 
Range on Protein: 3-162
Range on HMM: 42-225/272.0
VDCKVSTIVMLCGDE----DCCYQYWT--------------GSMRHGEFSVEVNNKRSANGYTERNLKLS---FDKESRNVLQFQVTDWPQDGVVRKAgt
 . ...|||.|...|    . |..||                ....| ..| .  .   . |. |.| |.     .|.| |.... |||| .|| ..|  
kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..

ILQVINEVRNrqkRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVD--------VFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
.|........    |||.||||  ..|.|... . . |..  .| .||        .... . .|.  |||| |.|||  .|...  ..
llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3-158 1.7e-14 48.1 In-house 102-265 (281) alignment 
Range on Protein: 3-158
Range on HMM: 102-265/281.0
VDCKVSTIVMLCG----DEDCCYQYWT----GSMRHGEFSVEVNNKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQk
 . . ..|||||     . . | .|.       ..  ..||. ..    .      |.||.. |.| . ..   .||.  |   .  .|... ..| |  
wqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.

rGPVVVHCSDTVSRSGVYCSVSIALEQCIK-EGVVDVFQVTKTVRRS-KPGAVTTPEQYDSIYDII
  | |.|||  | |||   .| |||.       . |. |.   .| . .  .| | .||  |. ..
.tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 6-162 2.1e-18 61.5 In-house 91-259 (290) alignment 
Range on Protein: 6-162
Range on HMM: 91-259/290.0
KVSTIVMLCGDED--------CCYQYW----TGSMRHGEFSVEVNNKRSANGYTERNLKLSFDKESR-NVLQFQVTDWPQDGVVRKAGTILQVINEVRnr
||  .||||  |.         | .|      .... . ..|.  .|   ..  .|.| . ||.|    |   .. .| .  | ..  |.|..|. |.  
kvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..

QKRGPVVVHCSDTVSRSGVYCSVSIALEQCI-KEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
... ||.||| | .||| .  .. ..    . ..| | . .| |..|. .  |.|.....  .   | |..
asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 6-163 4.1e-07 22.9 In-house 154-310 (346) alignment 
Range on Protein: 6-163
Range on HMM: 154-310/346.0
KV-STIVMLCGDEDCCYQYwTGSMRHGEFSVEVNNKrsANGYTERNLKlsfDKESRNVL--QFQVTDWPQDGVVRKAGTILQVINEVRNRQKRGPVVVhC
|.  |   |  ||.  ||| || |   .   .|      . ||   |    . .|  |.    . . | .     |.  |...| .    ..   . | |
klkntttslfndenggyqy.tgkmfinnrradvsgd..pkeytievlp...egnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagv.c

SDTVSRSGVYCS---VSIALEQcIKEGV-VDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
  ..  .|  ||      |..| . .|.  ..... |.... .||.| .  || ||| |.  || 
vvslfgcgracsfigalyainq.lnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
subfamily_PTPN6_pd Subfamily PTPN6 9-166 1.2e-29 98.3 In-house 125-301 (306) alignment 
Range on Protein: 9-166
Range on HMM: 125-301/306.0
TIVMLCGD----EDCCYQYWTGSM---RHGEFSVEVNNKRSANGYTERNLKLS---FDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQK----
 |||.  .    .. |..||  .    ..|. ||.  ...|.. |. |.|..|   ..||.|.| |.. ..||. || .. |..|. ...|...|.    
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

--RGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQTTN
   ||.|||||. . | | .  . | |..  |.|.   .|. .. |.||. . | | | .||  .| .|  ||.|..
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 9-155 1.9e-19 64.8 In-house 78-233 (239) alignment 
Range on Protein: 9-155
Range on HMM: 78-233/239.0
TIVML----CGDEDCCYQYWTGSM-RHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQKRG--PVV
 ||||     | .  |.|||  |  .. .. | . .      |  | . .|   . | | | |...| ||. || . | ..| .  .. .    |  | |
vivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwv

VHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIY
.|||  | |.| .  .   | |. |.  ||.|.  |..|  .|  | | |||  |.
ihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 9-155 2.1e-19 64.6 In-house 79-234 (239) alignment 
Range on Protein: 9-155
Range on HMM: 79-234/239.0
TIVML----CGDEDCCYQYWTGSM-RHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQKRG--PVV
 ||||     | .  |.|||  |  .. .. | . .      |  | . .|   . | | | |...| ||. || . | ..| .  .. .    |  | |
vivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwv

VHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIY
.|||  | |.| .  .   | |. |.  ||.|.  |..|  .|  | | |||  |.
ihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_PTPN1_pd Subfamily PTPN1 16-155 9e-20 65.5 In-house 109-264 (290) alignment 
Range on Protein: 16-155
Range on HMM: 109-264/290.0
DEDCCYQYWTGS-------MRHGEFSVEVNNKRSANGYTERNLKLSF--DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNR----QKRGPVVVHC
..  |.|||          . . ...|.. .. . . || | |.|     .|.|..|.|  | ||  || .  .. |. . .||.     .. ||.|.||
eqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc

SDTVSRSGVYCSVSIALEQCIKEGV---VDVFQVTKTVRRSKPGAVTTPEQYDSIY
|  . ||| .| |   | .  |..    ||. .|   .|. . | . |..| .  |
saGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_ptpA1_pd Subfamily ptpA1 23-120 1.3e-11 38.9 In-house 147-254 (418) alignment 
Range on Protein: 23-120
Range on HMM: 147-254/418.0
YWTGSMRHGEFSVEVNNK--RSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQK--------RGPVVVHCSDTVSRSGVY
|  |    | .|||. .           ||..|.|. |.|.. |.|   ||.  .  ..  . |..  . |||.          |..||||  | |.| .
ygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtf

CSVSIALE
|.  | ..
ctavimmk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 26-156 9e-12 39.6 In-house 56-197 (198) alignment 
Range on Protein: 26-156
Range on HMM: 56-197/198.0
GSMRHGEFSVEVNNKRSANGYTERNLKLSFD----KESRNVLQFQVTDWPQDGVVRKAGTILQVI--NEVR---NRQKRGPVVVHCSDTVSRSGVYCSVS
|. ..| .|| ..   .   ||   | |. .      .|.. ..| | | .      |  .  |.   ||    ...|  ||.|||||    .||. .. 
gtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald

IALE--QCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
| .   .  |  |||.|.|.| .|... | ... ..|. ||.
igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 26-156 9.1e-12 39.6 In-house 57-198 (199) alignment 
Range on Protein: 26-156
Range on HMM: 57-198/199.0
GSMRHGEFSVEVNNKRSANGYTERNLKLSFD----KESRNVLQFQVTDWPQDGVVRKAGTILQVI--NEVR---NRQKRGPVVVHCSDTVSRSGVYCSVS
|. ..| .|| ..   .   ||   | |. .      .|.. ..| | | .      |  .  |.   ||    ...|  ||.|||||    .||. .. 
gtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald

IALE--QCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
| .   .  |  |||.|.|.| .|... | ... ..|. ||.
igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048076 (Phosphotyrosine protein) phosphatases II 39-159 3.9e-18 61.0 In-house 24-140 (145) alignment 
Range on Protein: 39-159
Range on HMM: 24-140/145.0
NKRSANGYTERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQKRG-PVVVHCSDTVSRSGVYCsvsiALEQCIKEGvVDVFQVTKTV
. .. . .|  ||   .. ..|...|.. ..||  ||   . ..|.... ... .|.| ||.||||  |.|.|...    |.  ....| |..... . |
llkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelv

RRSKPGAVTTPEQYDSIYDIID
|.  ||||..|.|.  .|. . 
rsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 41-151 2.5e-08 28.0 In-house 155-265 (312) alignment 
Range on Protein: 41-151
Range on HMM: 155-265/312.0
RSANGYTERNLKLSFD---KESRnVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQKrgPVVVHCSDTVSRSGVYC---SVSIALEQCIKEGVVDVFQVt
.| .  | | ||.      .||. . ..| . ||. |.     | |...  |.. .|  ||. |||  | |.|  .   |.  || .  |. | |.| . 
kskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl.

ktVRRSKPGAVTTPEQY
  .|. .  .| .  ||
..lrkdrarsvrvfpqy
0048179 (Phosphotyrosine protein) phosphatases II 43-156 6.3e-16 53.9 In-house 48-139 (144) alignment 
Range on Protein: 43-156
Range on HMM: 48-139/144.0
AngyternlklsfdkesrnVLQFQVTDWPQDGVVRKAGTILQVINEVRNR-QKRGPVVVHCSDTVSRSGVYCSVSIALeqciKEGvVDVFQVTKTVRRSK
                   ..|.. ..||  ||   .  .|.... ...  .. |||.||||  |.|.|...   . .    |.| ...... . ||.  
e..................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

PGAVTTPEQYDSIYD
||||..|.|.  ...
pgavpnpgqlrfLle
PTPc_motif_SM00404 44-114 1.5e-06 23.1 In-house 41-99 (140) alignment 
Range on Protein: 44-114
Range on HMM: 41-99/140.0
NgyternlklsFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVrnRQKRGPVVVHCSDTVSRSGVYCS
.            ......|| .. |  .| ....   .|..|...  ..|.| |.|||   ||||.  . 
t..........kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatlii
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 44-120 8.3e-06 19.4 In-house 201-290 (349) alignment 
Range on Protein: 44-120
Range on HMM: 201-290/349.0
NGYTERNLKLSFDKES-RNVLQFQVTDWPQDGVVRKAGTILQVINeVRN-------------RQKRGPVVVHCSDTVSRSGVYCSVSIALE
.   . .  . ...|.   .||.|| .|.  ...    .||| .. |.|              ..  ...||||    |.||.. . . |.
lpddddddaillavekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 48-159 3.3e-14 47.6 In-house 164-274 (307) alignment 
Range on Protein: 48-159
Range on HMM: 164-274/307.0
ERNLKLSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQkrGPVVVHCSDTVSRSGVYCSVSIALEQCIK-EGVVDVFQVTKTVRRSKPGAVT
  .||. . ..|| . ..| ..||. || .   | . ... ||  .   |||||||  | |||   ..|.  .. |. .   |. .. . .|  .. |. 
vttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt..npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq

TPEQYDSIYDIID
|  ||  .. .. 
teaqylylhrvll
DSPc Dual specificity phosphatase, catalytic domain 53-113 1.3e-06 23.4 Pfam-A 33-91 (133) alignment 
Range on Protein: 53-113
Range on HMM: 33-91/133.0
LSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVrnRQKRGPVVVHCSDTVSRSGVYC
 .. |.... |. .| |  .. ....   . ..|...  .||.. |.|||   .|||.  .
naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatli
DSPc Dual specificity phosphatase, catalytic domain 53-113 1.3e-06 23.4 In-house 33-91 (133) alignment 
Range on Protein: 53-113
Range on HMM: 33-91/133.0
LSFDKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVrnRQKRGPVVVHCSDTVSRSGVYC
 .. |.... |. .| |  .. ....   . ..|...  .||.. |.|||   .|||.  .
naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatli
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 56-151 6.5e-13 42.8 In-house 184-277 (302) alignment 
Range on Protein: 56-151
Range on HMM: 184-277/302.0
DKESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQKrgPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQY
.|  . |  .. . ||. |  ..| | |....     .|   |.||||  | |.|   ..   .. | |. | |. .. . ||. . ||| . .| 
kkvkktvdilafsawpdhGapkeaytaldilkfcesykk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
0049772 (Phosphotyrosine protein) phosphatases II 57-164 5.7e-14 48.0 In-house 175-282 (314) alignment 
Range on Protein: 57-164
Range on HMM: 175-282/314.0
KESRNVLQFQVTDWPQdGVVRKAGTILQVINEVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCikeGVvDVFQVTKTVRRSKP-----GAVTTPEQY
. .|.....  ...|  | .     ...... ... .| |||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. ..|||
lferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqy

DSIYDIIDLYIQT
  |....  |...
efilealleylkf
subfamily_DSP12_pd Subfamily DSP12 57-113 1.3e-07 26.1 In-house 46-100 (155) alignment 
Range on Protein: 57-113
Range on HMM: 46-100/155.0
KESRNVLQFQVTDWPQDGVVRKAGTILQVINEVRnrQKRGPVVVHCSDTVSRSGVYC
|   . .. |..| |.  ...   .... |.| .  ...| |.|||   ||||   .
kgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 58-163 1e-11 39.1 In-house 184-288 (305) alignment 
Range on Protein: 58-163
Range on HMM: 184-288/305.0
ESRNVLQFQVTDWPQDGVVRKAGTILQVINEVrnRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVD-VFQVTKTVRRSKPGAVTTPEQYDSIYD
..| | ..   |||. ||     .||.....   |  .||.|||||  . |.|    .   |.| .   ...   .. . .|  .  .. | .||  ...
karkvthyhwidwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq

IIDLYIQ
.|  |..
vilnyfr
subfamily_DSP14_pd Subfamily DSP14 59-117 7e-06 20.1 In-house 49-105 (157) alignment 
Range on Protein: 59-117
Range on HMM: 49-105/157.0
SRNVLQFQVTDWPQDGVVRKAGTILQVINEVRNrqKRGPVVVHCSDTVSRSGVYCSVSI
. .... .|.| |.  ...   .. . |.||..  | | ..|||   ||||   | . .
diervkvpveDnpeaklakhfdevadkieevkk..kggktlvhCvaGvSRSAslclayl
subfamily_DSP19_pd Subfamily DSP19 60-142 2.4e-07 25.2 In-house 56-131 (152) alignment 
Range on Protein: 60-142
Range on HMM: 56-131/152.0
RNVLQFQVTDWPQDGVVRKAGTILQVINEVRNRQkrGPVVVHCSDTVSRSgvycsVSIALEQCIKEGVVDVFQVTKTVRRSKP
 ..|. .. | |.  ...   ..|. |.|.|. .  | |.|||.  ||||     .|...   .|.  ... .  ..||  .|
ftylsieilDlpetdllsylkealdFieearskd..gavlvHCnAGvSRs.....asvviaylmkkeelsleealelvrearp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 60-122 4.3e-06 20.7 In-house 215-289 (350) alignment 
Range on Protein: 60-122
Range on HMM: 215-289/350.0
RNVLQFQVTDWPQDGVVRKAGTILQVIN------------EVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQC
  |.|.||  |.  ... .   |||...            .  . ..  |..||||  | | |.....   |.. 
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf
PTPc_DSPc_SM00012 62-158 8.4e-26 85.6 In-house 2-103 (105) alignment 
Range on Protein: 62-158
Range on HMM: 2-103/105.0
VLQFQVTDWPQDGVVRKAGTILQVINEVRNRQK----RGPVVVHCSDTVSRSGVYCSVSIALEQCIKE-GVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
| ....|.||. || ...  ||.....|.. ..    ..|||||||. |.|.|... ..|.|.|. || . ||.||. | .|...||.|.| |||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

II
..
al
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 62-159 5.3e-11 37.1 In-house 173-268 (288) alignment 
Range on Protein: 62-159
Range on HMM: 173-268/288.0
VLQFQVTDWPQDGVVRKAGTILQVINEVRNRQKrgPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIID
| .  . .|..|||  .  . |.... ... ||  |.|||.|  | |.|    . ||||.   .  . . .. .  | ..  |..|  ||  .. .. 
vkilhlleWdddgvPenylsplrllevlkslqk..PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 62-159 1.6e-06 22.3 In-house 169-267 (285) alignment 
Range on Protein: 62-159
Range on HMM: 169-267/285.0
VLQFQVTDWPQDGVVRKAGTILQVINEVRN-RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIID
. . ||  ||..     |  .... . |..   |  |..||||  | |.  .  .  |  . ...  ...... . .|  .  || .  |.  .| .. 
mnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_DSP1_pd Subfamily DSP1 64-138 2.8e-06 21.5 In-house 66-136 (163) alignment 
Range on Protein: 64-138
Range on HMM: 66-136/163.0
QFQVTDWPQDGVVRKAGTILQVINEVRNrqKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKegVVDVFQVTKTVR
. .. | |.. .     .... |.||..  |.| | .||   .|||   | . .  .. ..  . . |. .| .|
klkleDspkadislvfeeviefidevkk..knGkvlihCqaGisRsstlclaylmktkrvs..leeafdfvkqrR
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 65-156 6.9e-09 29.7 In-house 195-284 (310) alignment 
Range on Protein: 65-156
Range on HMM: 195-284/310.0
FQVTDWPQDGVVR-KAGTILQvinEVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYD
 .  .||. ||   |  |. |    .  . . ||.|||||  . | .| ... .....  .   ||. .|   ...|.   . |. ||  |  
ikwpnwpdrgvpdekchtvpq...rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 66-164 6.2e-10 33.0 In-house 187-287 (302) alignment 
Range on Protein: 66-164
Range on HMM: 187-287/302.0
QVTDWPQDGVVRKAGTILQVINEV--RNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYIQ
 .| |.|. |  | ... . . .|  .. .   ..|.     . | |.  .. .|.|.  |.  . . .. |..|  .| || . .|| |.| .. |||.
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

T
.
k
subfamily_DSP23_pd Subfamily DSP23 81-160 3.5e-06 21.7 In-house 72-144 (148) alignment 
Range on Protein: 81-160
Range on HMM: 72-144/148.0
TILQVINEVRNRQKrgPVVVHCSDTVSRSGVYCSVSIaleqcIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDL
 ...|..|  ....   | |||     |.|   .  .     .||  .   .    ||| .||.| | || . ..|   .
efvrvveeaeekne..avsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvrdyetf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 83-158 8e-09 29.8 In-house 216-291 (297) alignment 
Range on Protein: 83-158
Range on HMM: 216-291/297.0
LQVINEVRNRQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDII
||.     .  .  ...||||  | ||||     . |..  |. . ||  . . .|  ..  | | ||.. .||..
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_CG42327_pd Subfamily CG42327 92-162 1.8e-13 44.9 In-house 244-315 (319) alignment 
Range on Protein: 92-162
Range on HMM: 244-315/319.0
RQKRGPVVVHCSDTVSRSGVYCSVSIALEQCIKE-GVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDIIDLYI
|...||.|||||| | |.|.  .  ||...  .    ||. |.   ||| .  || | |||. || ..  | 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 99-157 1.2e-06 22.8 In-house 2-60 (69) alignment 
Range on Protein: 99-157
Range on HMM: 2-60/69.0
VVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDI
|||||    |.| . .. . . .   | .||.|   . .|. .|  |    .|  |.| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 99-157 2.9e-06 21.5 In-house 1-59 (69) alignment 
Range on Protein: 99-157
Range on HMM: 1-59/69.0
VVHCSDTVSRSGVYCSVSIALEQCIKEGVVDVFQVTKTVRRSKPGAVTTPEQYDSIYDI
|||||    |.| . .. . . .   | .||.|   . .|. .|  |   ..|  |.| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda