Gene PTPRD-43 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP099_AA protein Get Run
AqueP099_AA_1880-2160 phosphatase_domain Get Run
AqueP099_AA_2172-2457 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ig_3 Immunoglobulin domain 476-563 6e-07 21.6 Pfam-A 2-74 (75) alignment 
Range on Protein: 476-563
Range on HMM: 2-74/75.0
PVVTSRLNTTGRIFESndIQLLCFVTFTPLdvepNVNISWFgpnglitmnDAKYSISTGEINPTTNGSSLTFT-ASLSDNGTdYYCTAS
||...  ..|    ..  ..| | .. .|     ...|||          . . ... |  .. ...|.||.. .. .|.|| | |.||
Pvisvspsptvtsggn..vtLtCsaeggpp....pptisWy.........ietppelqgsegssssestLtissvtsedsGt.YtCvas
Ig_3 Immunoglobulin domain 628-713 3.6e-06 19.1 Pfam-A 5-74 (75) alignment 
Range on Protein: 628-713
Range on HMM: 5-74/75.0
SINIPSVPVAGDVFNLSCIIVVPPNfvenLTSVRWTydleasqdvtseNNDATLVPVVRNRNIFTSVLTLDPVKTTDARQYYCQAT
|........ |   .|.| .. .|      ....|.            .     .. ......  |.||. .|.  |   | |.|.
svspsptvtsggnvtLtCsaeggpp....pptisWy............ietppelqgsegssssestLtissvtsedsGtYtCvas
Ig_2 Immunoglobulin domain 743-848 9.5e-06 17.6 Pfam-A 7-80 (80) alignment 
Range on Protein: 743-848
Range on HMM: 7-80/80.0
PTGPIYESTGYLLTCTATvnttivdTPVTASVVWTDPsGNVIPTNEARrqvipptgnslvsmlLFQPIDTglNNDGGTYTCQMIISSGnsliassQPTNT
|  .. |..   |||.|.          |..| |.   |. .......               ||.|. .   .|.|||||..  |.|       . ...
pptvvtegenvtLtCqap.......gnptpkvqwykd.geelsqsqna...............lfipnvs..aedsGtYtCrasnseg.......skqsn

TLNVTV
...|||
svevtv
V-set Immunoglobulin V-set domain 859-945 9.4e-06 16.5 Pfam-A 8-101 (114) alignment 
Range on Protein: 859-945
Range on HMM: 8-101/114.0
SSVGSVEVGQSLTIICTIRtveRlVVTP-MVTFIKMND-TDMEMLS-N--------LNRPYSIITNDTGSGSVTNYTLILDPVRFEDAGMYTCMAEFN
.....|..|.|.|. |. .   . . .  .....| .. ...| .  .            .|  .. ...|| ....| .  .| || |.|||... .
prpvtvaeGgsvtLpCfys...s.sensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds
I-set Immunoglobulin I-set domain 1108-1184 1.3e-06 20.1 Pfam-A 12-81 (90) alignment 
Range on Protein: 1108-1184
Range on HMM: 12-81/90.0
AEPGEEYMLNCTVTVVDrlivSPVITWTKRsANNVTSVPPVLINVSNvmTSLYLRFPSLNTSDAGLYTCEASINVTQ
.. ||.  |.|||. .      | ..|.|.  ....|   | ..|..   .  |.. . ..||.| |||.|. .. .
vseGesvelectveGep....epsvsWakd.gselkssqrvkvtvee..aeytLtIsnvevsDeGkYtckatnsagk
Ig_2 Immunoglobulin domain 1108-1183 2.8e-06 19.3 Pfam-A 11-69 (80) alignment 
Range on Protein: 1108-1183
Range on HMM: 11-69/80.0
AEPGEEYMLNCTVTvvdrLIVSPVITWTKRSaNNVTSVPPVlinvsnvmtsLYLrfPSLNTSDAGLYTCEASINVT
.. ||   |.|...        |...|.| . . ... .            |..  |... .|.| |||.||   .
vtegenvtLtCqap....gnptpkvqwykdg.eelsqsqna..........lfi..pnvsaedsGtYtCrasnseg
Ig_2 Immunoglobulin domain 1211-1331 5.9e-08 24.6 Pfam-A 6-78 (80) alignment 
Range on Protein: 1211-1331
Range on HMM: 6-78/80.0
SKEDYFLAGSNLVLTCDISvdpnvDTPFtVNVTWNMTDQQIMSSgdfgdesspnsmrlpdtdrvnissvmmR-SgfneyrstvNFTTLSSMEDSGTYTCI
.   .  .|.|..||| ..     . |. ..|.|   .... .|                           .            |. . |.|||||||| 
apptvvtegenvtLtCqap.....gnpt.pkvqwykdgeelsqs...........................qna.........lfipnvsaedsGtYtCr

VtivpdRAYEYvmTSDTNYMNV
.     . .|.     .|...|
a.....snseg..skqsnsvev
fn3 Fibronectin type III domain 1352-1426 2e-08 27.4 Pfam-A 13-84 (85) alignment 
Range on Protein: 1352-1426
Range on HMM: 13-84/85.0
PRNVTLTWTEPPliDQNGAPVGYNLTCMNTNGVSvnGLSPTQTSMNT-MFTVTDVMPFTGYTCDLSFINVVGYGPS
....||.|..|.  |..|  .||.... ...| .       ... .|  .|.|.  | | |.. .  .| .|.||.
stsltlsWsppk..dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 1442-1525 7.3e-08 25.6 Pfam-A 3-85 (85) alignment 
Range on Protein: 1442-1525
Range on HMM: 3-85/85.0
PQNFTSTP-TMTTVTFTWTSPSIRNGIITGYQLKVTNIETNA-YRTMNISSDQLMYTLDEegfFSAYDNYTASVTASTVIGFGPIS
|.|.. .. | |..|..|. |. ..| ||||.... . ...   .. ......  .|| .     .. .|. .|.| .  | || |
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltg...LkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1558-1635 2.1e-07 24.1 Pfam-A 10-82 (85) alignment 
Range on Protein: 1558-1635
Range on HMM: 10-82/85.0
SVDNHTINVTWYPPTTPNGRIMNYTIEVdgY-ITRNRliRRTI-TdVDRDSFtvLITDNALTPGVPYSVTLVAYNEFGRG
.| .......| ||....| | .|..|.     . ..    .  | |.|..     | . |.|| .|.... |.|. | |
evtstsltlsWsppkdgggpitgYevey..rekggge..ewkeft.vprttt..svtltgLkpgteYefrVqavngageg
fn3 Fibronectin type III domain 1652-1727 2.5e-08 27.1 Pfam-A 2-73 (85) alignment 
Range on Protein: 1652-1727
Range on HMM: 2-73/85.0
SPSNVQAVRSdDGTNMTITWDAVSlTQARGFFEYTIRLSRSSRKRqaGDLVYRVPSTETSYTATDLDDQATYSVSM
.|.|...      |..|..|.. . .. . .  |..... ..  .   .  ..||.|.||.| |.|   ..|... 
aPenlsvsev.tstsltlsWsppk.dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrV
Mid2 Mid2 like cell wall stress sensor 1764-1796 9.8e-06 13.0 Pfam-A 48-79 (155) alignment 
Range on Protein: 1764-1796
Range on HMM: 48-79/155.0
NISTIIGIVVGVVLALLLIVLIvVIIIFIVRRG
|   .||.|||.   |||..|. .| || ..  
nkniviGcvvGigvPlllvilv.liyifCikek
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1873-2168 9.3e-70 230.1 In-house 6-293 (297) alignment 
Range on Protein: 1873-2168
Range on HMM: 6-293/297.0
ERmKPIAVASFHEHVQE-MHVDsdkGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRkdCYIAAQG
|| .|| .. |   ||. .|.|    |. |.. .|  . ..    ..  |  |.|..|| |||.|||||  .   |||||.|| .. |..    .|. | 
er.rpiplsdfatlvqknrhtd...vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqm

PLPSTVADFWRTIWEYRINHIVMLTGVVEGGKkKCEQYWPEKVGENlelPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDlTVSHYHFTSWPDHGVPQ
| ..||||||. ....... ||||.   |. | || .||..|   .       .|...|  .   .| |... .| ..  .   |  |.|..|||. |..
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarr.vvkqyqfveWPdkaver

--FATSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIG
   |.||. .|. |.||... .  ||.|||.||||||| .. .| .. . |.|...........|| .|.|.|||. || |.. |. |   . || |  
kdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_PTPRB_pd Subfamily PTPRB 1874-2159 3.7e-100 329.7 In-house 3-285 (293) alignment 
Range on Protein: 1874-2159
Range on HMM: 3-285/293.0
RMKPIAVASFHEHVQEMHVDSDKGFEMEYKSVP-MQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGP
. ||| . .|.|||..|. ||| .|  ||...  ...... .. ... |..|||. || ||| |||||..| . ..|||||| ||.||| .  .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvgENLELPNGFTVTMTSFVQFADYIIRDFKASKaesDEKDLTVSHYHFTSWPDHGVPQF
||.|| |||| .|| . . ||||| .||.||.|||.|||..  |.  |    .||...  .  |..||..| .|   ...  .| .||||||||||||. 
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad..eepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPek

ATSLISFIKRVQKDH-NKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELT
...|..|...|.. . .. .  |..|||||||||||||| || .......|. .... .. .||..|...|||..||.|.|... .| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0050432 (Phosphotyrosine protein) phosphatases II 1874-2159 4.2e-95 313.9 In-house 22-299 (308) alignment 
Range on Protein: 1874-2159
Range on HMM: 22-299/308.0
RMKPIAVASFHEHVQEmhVDSDKGFEMEYKSVPMQTE-TSFDIGRNEGNKTKNRFANIFPYDFSRVKLtelpGvPDSDYINACYIDGY--NRKDCYIAAQ
 .... | ........   .. ...|.|.. ......  ...... . ||.|||. .|.||| |||||    . ..|||||| |.|||  ...  .||.|
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatq

GPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVP
||||.||.|||| .||.....|||||  || |..||.||||...|.. .  ..||||..|  ...||..| .. .. ...|  .|| |.|.|.|||||||
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvP

QFATSLISFIKRVQKDHnkdKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELT
. ...|..|...|.| .   .| | .||||||||||||||.||.....|..|  ..|.|....||..|..||||  ||.||..|| |. 
pspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1875-2181 4.2e-155 510.4 In-house 1-305 (305) alignment 
Range on Protein: 1875-2181
Range on HMM: 1-305/305.0
MKPIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQtETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLP
.|.||.........|..|.||||.|..|||.... |.|.|.|..| ||.|||...|...|..|..||| . ..|||||||.|.|||.||..||.|||||.
akiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

STVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFAT
.|||||||.|.|.....|||||..|||||.||.|||||...|. |. . |.|...|. ...|||.|..|.|....|... ||..|..|.|||||||||||
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRAR
||.|.|||||||..|||||||.|||||||||||.||..||...|||.||...|.|||.|||||||.||||..||||||||||||.|||||||||||||||
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

VNKMHKM
|||..||
vnklkkm
subfamily_PTPRA_pd Subfamily PTPRA 1875-2193 9.1e-96 315.6 In-house 11-329 (330) alignment 
Range on Protein: 1875-2193
Range on HMM: 11-329/330.0
MKPIAVASFHEHVQEMHVDSDKGFEMEYKSVPM-QTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPL
  |. |  . | ..    |  | |  |....|  . ......  .| || |||. ||.||||||| |... ||..|||||| .||||..|| .||||||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

PSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVgenLELPNGFTVTMTSFVQFADYIIRDFKAS---KAESDEKDLTVSHYHFTSWPDHGVP
  || |||| |||..   ||||| . |  ..||.||||..    |      .|..   .   || .|.|      .|  ..|   |. .||||||| |||
eetvedfwrmiweqksativmltelkerkeekcaqywPdeG...lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

QFATSLISFIKRVQKDHNKDKGvPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSN
  .  .....|.|.| ...  | |..||||||||||||||.|| ...|.| |. ..|.|....|| .|  ||||. ||.|.. .| |    ||| .  | 
fepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss

LRARVNKMHKMIPGKNITGFQEQ
|  ...|... |.| . .|..|.
lekhlqklynkitgtdkigleee
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1875-1971 2.6e-35 114.5 In-house 2-95 (95) alignment 
Range on Protein: 1875-1971
Range on HMM: 2-95/95.0
MKPIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTElpgVPDSDYINACYIDGYNRKDCYIAAQG
.||| |. || || ||| .||. |. |.||..| . ... .|  | |  |||| |||||| .|| ||      ||||||||..||| ||.|||||||
fkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_PTPRD_pd Subfamily PTPRD 1876-2236 7.9e-135 445.6 In-house 3-357 (564) alignment 
Range on Protein: 1876-2236
Range on HMM: 3-357/564.0
KPIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
||| ||...|||.... .||  ||.|||.. ........  ... || |||.||| .|| |||.|....|...|||||| .||||...  |||.||||..
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvGeNLELpNGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATS
|..|||| .||.... ||||| ..| ||.||..||||| | . .  ...|||... ...|||.||.|| .|..|.|.  .| ..|||||||||||..|||
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkksses.reVrqFhFtsWPdhgvpesats

LISFIKRVQKDHnKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARV
|...|..|.. . ...  |..|||||||||||||| .|.|..|.|.|. ...|.....||..| .||||. ||.|.|.|. |  .||.|..  .||....
lLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl

NKMHKMIPGKNITGFQEQYELLDQVGYKPSEMMySDGTTTVNVPKNRYPEIVPLNMHRPRL
.|.... .....||..  .. |     .. | . . .|  .|  |||...|..|.  |  |
qkLaeveedtemtgleleFqrLatakeieleef.avatkpknkkknrfsnilalescrvvl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1876-2194 9.4e-104 341.9 In-house 3-318 (319) alignment 
Range on Protein: 1876-2194
Range on HMM: 3-318/319.0
KPIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
..| |. ..|......  .....| |.| . . ....||   .| ||.|||. || .|| .||.|.||.||..|||||| .||||.... .||.|.||  
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEkvgENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATS
|. |||| .||...  .||||..|| .| |...||||   || |    ..||. .  . .|||||..|  |. |. .  .|.|...|.||||.||. |||
tiedfWrmvWeeessivvmltklveklkvklkkywpe...enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARV
|. ..||..| ..| .  |..||||||||||||||.||.|..|.|.|. ..|... ..|| .|  |||...|| |...|| |  ..||| |   .|| |.
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

NKMHKMIPGKNITGFQEQY
 .. . ...   ||.. ..
kqlaekvadtgetgleref
0045450 (Phosphotyrosine protein) phosphatases II 1876-2157 1.6e-92 305.8 In-house 7-302 (307) alignment 
Range on Protein: 1876-2157
Range on HMM: 7-302/307.0
KPIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTET---SFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGV-PDSDYINACYI--------DGYNRK
..| .  .  .|.... |.  |.. |..... .| .   ...|.. . ||.|||. .|.||| .||||. |.|  .||||||| |.        |||..|
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

DCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvGENLELPNgFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTS
. .||.|||||.||.|||| .||.....|||||. || |..|| ||||.. || |.  | ||||..|. . ..|..| .. .  . ... .|| |.|.|.
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHGVPQFATSLISFIKRVQKDHNKD-KGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEES---INVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
|||||||..  .|..||..|.| .... || | .||||||||||||||....|...|..|.    ....|....||..|. .||.. ||.||..|| |
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1876-2195 4e-88 290.4 In-house 4-315 (315) alignment 
Range on Protein: 1876-2195
Range on HMM: 4-315/315.0
KPIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
.|| .  .  .| . .  . .||. .|.|.|      .|. ..  || |||. || .|| |||.|  |   |.|||.|| .|||||.|. |||||||...
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvgenlELP-NGFTVTMTSFVQFADYIIRDFkasKAESDEKDLTVSHYHFTSWPDHGVPQFAT
.| |||| ..|. | .|||||..||| |.|.|.|||.|     ..    .|||. |  .. .| .| .      ....  .|  .|.||||| |||....
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkyti

SLISFIKRVQKdHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRAR
.|. .|..|.. |....  ...|||||||||||||| || ..|... |. |.||......|..|. |||. .|| |..||| |   ||||||       |
plmnlirtvkq.hhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqr

VNKMHKMIPGKNITGFQEQYE
 . .    |    | .|||.|
ydsllapspdtgstllqeqfe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1876-2179 2e-58 192.7 In-house 2-256 (392) alignment 
Range on Protein: 1876-2179
Range on HMM: 2-256/392.0
KPIAVASFHEHVQEMHVdsDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
.|| || |   |.. .      |  |.. .|        ....| |. |||. ||.||| .||||  .  .|||||.|| ||.... . .|||.||| ..
qpipvaqfpafveknrh..salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TVADFWRTIWEYRINHIVMLTGVVEGGkkkceqywpekvgenlelpngftvtmtsfvqfadyiirdfkaskaeSDEKDLTVSHYHFTSWPDHGVPQFATS
.. |||| ... ..  |.|.| . ||                                                 ... ||. .||| |||..||....|
slddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtss

LISFIKRVQKDHNKdKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARV
|. ||| |. |. .    ||..||||||||||  | .| .. . |.   ..|.... ..| || |||||. || |.. |. |     .| |    .  ..
llkfikevkadfGq.ythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhl

NKMH
....
qdls
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1876-1960 1.4e-14 48.3 In-house 4-86 (440) alignment 
Range on Protein: 1876-1960
Range on HMM: 4-86/440.0
KPIAVASFHEHVQEMHvdSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGY
.|| || | ..||. .    . || |.  .|    .  ||     || |||. ||. ||.||| | |. |||||||||| ||.| 
rpiivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
0051299 (Phosphotyrosine protein) phosphatases II 1877-2157 1.3e-97 322.0 In-house 4-284 (288) alignment 
Range on Protein: 1877-2157
Range on HMM: 4-284/288.0
PIAVASFHEHVQEMHVDSDKGFEMEYKSVPMQT-ETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
.| | .....|.... .. .|...|.. .. ..   .. ... . |..|||. .|.||| |||||. |.||..|||||| ||||||.|  .||.|||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEkvgENLELPNGFTVTMTSFVQFADYIIRDFKASKAE---SDEKDLTVSHYHFTSWPDHGVPQF
||.|||| .||.....|||||..|| |..||.||||.   .. .  . .|||..| ....||..| .. .. .    |.. .|| |.|.|.|||||||. 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

ATSLISFIKRVQKDHNkDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
...|..|...|.| .. ..| | .||||||||||||||.||.....|..|. ..|.|....||..|..||||  ||.|...|| |
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 1877-2175 9.9e-87 285.9 In-house 3-302 (307) alignment 
Range on Protein: 1877-2175
Range on HMM: 3-302/307.0
PIAVASFHEHVQEMHVDSDKGFEMEYKSVP-MQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
.||. . .| ..  . |.| |.. ||....  ... |  .. .. |. |||. .| ..|  ||||....|  ||||||| .| ||. |  .||||.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvgENLELPnGFTVTMTSFVQFADYIIRDFKASKAE--S--DEKDLTVSHYHFTSWPDHGVPQ
|. |||| |.|  .. ||||. . |  .|||..|||.   .. .      |.. |. .  |||||... || .  |   |.   |  ||.|.|.|  ||.
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe

FATSLISFIKRVQKdHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNL
 |..|. .|..|.. ..| .  |..|||||||||.|.|. ||.....||.|......|. ..|||.|  .||  .|||||. || . .. ||| .   .|
vargllklieqvre.lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl

RARV
  ..
edai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1877-2195 2.8e-78 257.9 In-house 2-313 (315) alignment 
Range on Protein: 1877-2195
Range on HMM: 2-313/315.0
PIAVASFHEHVQEMHVdsDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPST
|| || |   |.. .      |  |.. .|        ..|.. | .|||. ||.|.| .||||  .   |||||||| || ...   .|||.||||...
pipvaqfpafvnknrh..talfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

VADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNgFTVTMTSFVQFADYIIRDFKASKAEsdeKDLTVSHYHFTSWPDHGVPQFATSL
| |||| ......  |||.|   || | || ||||.. ..  |. . . |.. |  . .| ..| .   |.|   .  ||. ..|| |||.||.. ..||
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGs.ikvellsleadtdgvarklvtrkse...esrtvtqfqftewPdkGvdkqtssl

ISFIKRVQKDhNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARVN
. .|| |. | |. |  .|.||||||||||| .| .| .....|...|..|......||.||.|.|||. .| |..||. |     .| |.  ..  ...
lklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq

KMHKMIPGKNITGFQEQYE
 .|    |.  . . ...|
dlhtsvdgsgrskmtkefe
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1878-2193 2.5e-106 350.4 In-house 2-314 (318) alignment 
Range on Protein: 1878-2193
Range on HMM: 2-314/318.0
IAVASFHEHVQEMHVDSDKGFEMEYKSV-PMQ-TETSFDIgRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
| |  ...||.... . .  .. ||. . . . | ||..   .. ||.|||.||| .|| .||||..| |...|||||| |||||.||  |||||.||| 
isvedleshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLElpnGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATS
|. |||| .||     ||||| ..| ||.|...|||.|  ....     .|.... |...||..| || .. |..|.  .|  ||.|||||.|||. ..|
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg...klvvelkeevelsdyvlrefkvtrteeees.rqvrqyhytsWpdegvpesgas

LISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARV
|......|.| ..| .  |..|||||||||||.||..||...|.|.|. ..|... .|||..|  ||||. ||.|..|.| |  ..||| .  |.||.|.
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsri

NKMHKMIPGKNITGFQEQ
...... |    | .. .
relreqdpesgttemdae
subfamily_PTPRG_pd Subfamily PTPRG 1878-2174 1e-95 316.1 In-house 1-302 (563) alignment 
Range on Protein: 1878-2174
Range on HMM: 1-302/563.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETS---FDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDS-DYINACYIDGYNRKDCYIAAQGPL
. |  |..|| ..| |.|.||. |.... ..| ..    .  ... || |||  || .|| |||||..|||. .. ||||| |||||.... .||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEkvgENLELPNGFTVTMTSFVQFADY-----IIRDFKASKAESDEKDLTVSHYHFTSWPDHG
..|. |||| ||| . . |||.| .|| |..||..|||.   .. |  . ..||...  ..| |     .|...|  | .. .....| .||.|.|||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPQFATSLISFIKRVQKDHNKDKGvPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIG
||....  ..|.|. .. .... | |..||||||||||||.|.|| .. ...||...||...|...|..| ..|||. ||.|||||| |. . ..| .. 
vPehslpvLifvkkssaankaeaG.PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella

SNLRAR
..... 
eqveel
0043336 (Phosphotyrosine protein) phosphatases II 1878-2155 1.3e-92 305.5 In-house 2-273 (278) alignment 
Range on Protein: 1878-2155
Range on HMM: 2-273/278.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTV
| | .......|.. .. .... |..... ..  ...|.. . ||.|||. .|.|||.|||||. |.|..||||||| |.||||... .||.|||||.||
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

ADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPekvgENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLI
.|||| .||.....|||||. || |..|| ||||    .. .  ..||||.... ...||..|... ..  ..|. .|| |||...|||||||   ..|.
edFwrmvwelgvttivmLtelvelgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslslll

SFIKRVQKDHNkDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
.|.|.|..  . |.. |..||||||||||||||.|......|. |  ....|....||..|. .|||. ||.||..||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 1878-2159 1.4e-92 305.6 In-house 14-289 (297) alignment 
Range on Protein: 1878-2159
Range on HMM: 14-289/297.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETsFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGV-PDSDYINACYIDGYNR-KDCYIAAQGPLPS
| .  .. ... .. .|  ....|..... ...  . |.. . ||.|||. .|.|||.|||||. ..|| .||||||| |.|||.. .. .||.|||||.
iplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

TVADFWRTIWEYRINHIVMLTGVVEGGKkKCEQYWPEKVGenleLPNGFTVTMTSFVQFADYIIRDFKASKaeSDEKdLTVSHYHFTSWPDHGVPQFATS
||.|||| .||.....|||||  || |. ||.|||||..|      ..||||.... . ..|..| .. ..  ..|  .|| |...|.|||||||. ...
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..nges.rtvthfqytgwpdhgvppslel

LISFIKRVQKDHNKD-KGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELT
|..|.. |.. .... || |  ||||||||||||||....|...|. |  ..|.|....||..|...|||  ||.||.||| || 
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPRK_pd Subfamily PTPRK 1878-2194 1.8e-89 294.7 In-house 4-312 (314) alignment 
Range on Protein: 1878-2194
Range on HMM: 4-312/314.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPMQtetsFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTV
| ||   .... ..     ||  ||.|..      .|  ... |..|||. .| .|| |||.|. . | |.|||||| .||.|.|   .|..||||..||
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

ADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGEnlelPNGFTVTMTSFVQFADYIIRDFKASK-AESDEKDLTVSHYHFTSWPDHGVPQFATSL
.|||| .....   ||||| .|| |. || .||||.        . . |.. .    |....| |. .| | . |.  .| ...|..||||.||. ||.|
kdfWrlvydencasivmltelvevgrvkClkyWPedtev....ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

ISFIKRVQKDHNKDKGvPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARVN
.....||.| .....| ...|||||| |||||||..||..| ...|. ..|... ..|||... ||.|. ||.|..|.. |   ||.|.|  |...|   
lklvrrvkksqeeeaG.rivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl

KMHKMIPGKNITGFQEQY
.. .. |  | . ..|..
esirldpqtnssqlkeef
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1878-2169 2.6e-85 281.5 In-house 16-301 (319) alignment 
Range on Protein: 1878-2169
Range on HMM: 16-301/319.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTET--SFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
. .   .  ...   |  . .|.|.. .. ..      .    . || |||. ||...| ..|||  | |.  |||||| ...|| ||| ||||||||. 
fpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldn

TVADFWRTIWEYRINHIVMLTgvveggKKKCEQYWPEKVGENLElpnGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATS
|.||||| ||||..  ||.||      |.|| |||| |. .. |    | | ..|  . |.|..||.. |.    .    .  .||  |||.|||.... 
tladfWrmiweyncstivllt......kdkcsqywplkivikee...rfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd

LISFIKRVQKDHNKDKG-VPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGS
|. ..|.|.. ..| ..  ...|||||||||||..|.||...||.|.|. ..||...|.|| .|  .||  .|| |.. || |    | . .   
lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1878-2155 1.8e-74 245.2 In-house 2-279 (290) alignment 
Range on Protein: 1878-2155
Range on HMM: 2-279/290.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPM-QTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPD--SDYINACYIDGYNRKDCYIAAQGPLP
| |  | |.|.. |.  ..||. ..|..   . | .  .|  . ||..|||||| .||  |. | ...| .|   .|||||||.||. |  |||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

STVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENlelPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHG-VPQFA
.|..|||. ||. ..  ||||| ..| ||.|| ||||..  ..    . |......  .. .||.| ..  . .|...  .| .|..|.|...| |.. .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka...ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq

TSLISfIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
|.|.. |....| . |.   ...||||..|||...|. ... ... |.|  |.|..||...|.... .|||. || .... .
tillv.ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1878-2183 4.2e-73 241.3 In-house 5-312 (325) alignment 
Range on Protein: 1878-2183
Range on HMM: 5-312/325.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTV
|||  . |||.. . . . ||  |.. .| .   .. .     || |||| |. ..| ||| |  .   |.|||||| |.  . .|| ..||| ||..|.
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

ADFWRTIWEYRiNHIVMLTGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFKAsKAESDEKDLTVSHYHFTSWPDHGVPQFATSLI
 |.|| . ..|   .|... ....||..| .|||...|.  ..  |. | . .  ...||. | ..  |  .. . ..|  ... ||.| ||... ..||
ndlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktf.Gglevklrtieeisdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatli

SFIKRVQKDHNKDK-----GVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLR
|... |.. ... .       |..|||||||||||.|| |  ..... .| ..........|| .|  ||.|  ||.....|| |   .|.| .  |.. 
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfe

ARVNKMHKMIP
|... ...  |
aklsslqernp
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1878-2164 2.5e-70 231.7 In-house 2-283 (287) alignment 
Range on Protein: 1878-2164
Range on HMM: 2-283/287.0
IAVASFHEHVQEMHVDSDKGFEMEYKSVPM--QTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTelpgVPDSDYINACYIDGYNRKDCYIAAQGPLPS
|.|  | | |.. |  ...||.  .. .    |.| .  ..  . || |||...| ..|  || |       . |||||..||||. |  .|.|..|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGenLELpNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHG-VPQFAT
|. .||. |.. ... ||||.   |  ...| |||||.    . |   .......  . |.||.|...  . ..... ..|  |..|.|...| |....|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvl.GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SLISFIKRVqKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDT
.|. . ... | . |    ...||||..|||...|.  .. ... |.|  |.|..||.. | ... .||| .|| |. |.. |  ....|
illvieemy.ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1880-2166 2e-89 294.8 In-house 11-297 (298) alignment 
Range on Protein: 1880-2166
Range on HMM: 11-297/298.0
VASFHEHVQEMHVDSDKGFEMEYKSVPMQTE----TSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPS
 | ... .. ..  .  |...|.. .   ..    .. ...|.. || |||.|.| ..|.||| |..  .  .|||||| ....|.... .||.|.||..
kaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte

TVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLelpNGFTVTMTSFVQFADYIIRDFKASKAESDeKDLTVSHYHFTSWPDHGVPQFATS
||.|||| ..|. |. ||||| ..| .| |...|||..  |.    . .||.. |  .|||.|.| .| ||.... |  .| . |||||||.|||. |||
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegkety...geitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenats

LISFIKRVQKdHNKDKG-VPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSI
.. ....|.. .... | .|..|.|||||||.|||| .| ...|.|.|... |..|.. || ||. .|||..||||...|  | ...... |
vldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_ptpA1_pd Subfamily ptpA1 1880-2120 1.4e-44 147.5 In-house 10-257 (418) alignment 
Range on Protein: 1880-2120
Range on HMM: 10-257/418.0
VASFHEHVQEMHVDSdKGFEMEYKSVPmQTETSfdIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDcYIAAQGPLPSTVAD
.  ...|.. .|    . | .  .||   .|||   | .. | .|||..||.| ...||.| ..     |||||| ||||   |. .|..||||| |.||
iynlknhikcihkik.eefrlleesvg.psets..egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiad

FWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVG-ENLEL-PNGFTVTMTSFVQFADY--------IIRDFKaSKAESDEKDLTvsHYHFTSWPDHGV
||| .|| |   ||||.   |  . ||..||||..| |.. .  ||  |  |  |.. .         | |. .    | . .|.|  .|..  |||| .
fwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnir.ltfegetrdit..qyqyegwpdhni

PQFATSLISFIKRVQKDH-----NKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLK
|...  .  ... . . .     . |. ||..|||||||||||||    ||| .| 
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
0040438 (Phosphotyrosine protein) phosphatases II 1881-2195 1.1e-98 325.7 In-house 3-312 (317) alignment 
Range on Protein: 1881-2195
Range on HMM: 3-312/317.0
ASFHEHVQEMHVDSDKGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADF
 ....... ..  . .... |.. .. ..  ...... . || |||. .|.|||.|||||. |.|..||||||| |.||.|.|. .||.|||||.||.||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEkvgENLELPNGFTVTMTSFVQFADYIIRDFKASKAeSDEKDLTVSHYHFTSWPDHGVPQFATSLISFI
|| .||.....|||||  .| |..||.||||.   ..    ..||||..|... |....| .. ..   |.. .|| |.|.|.|||||||.  ..|..|.
wrmvweqgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfl

KRVQKDHNkDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARVNKMHK
..|..  . |.| |..||||||||||||||....|...|..|. ..|.|....||..|...||| .||.||.||| |. ....|..  |.|  .. |.. 
eavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli

MIPGKNITGFQEQYE
 ..... .. .....
plalddvklkekelk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1882-2177 3e-65 215.4 In-house 6-297 (439) alignment 
Range on Protein: 1882-2177
Range on HMM: 6-297/439.0
SFHEHVQEMHVDSDKGFEMEYKSVPMQTE---TSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVA
 |.|||.... . .. |. .....            .  .| ..||||. .. ..|..|| | |.|||| | |||| ||.||  .. |||.|||   |. 
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRTIWEYRINHIVMLTGVVEGGKkkceqYWPEKVGEnleLPNGFTVTMTSFVQFADYIIRDFKA-SKAESDEKDLTVSHYHFTSWPDHGVPQFATSLI
|||| ..| .  .||||| .||  |     ||| .           .| .   ... .|.|| ||   . .. ||. || ..|...|||. ||  |. ..
dfwrlviekktvtivmltnlvesyk.....ywpsdaev...cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

SFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARVNK
 |.. ..   .|..  |..|||||||||||| | ||| ...|| |. ...  ... || .|  |||. .||||...|. |    ||...   ... ..| 
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefna
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1883-2159 4.8e-93 306.3 In-house 9-279 (288) alignment 
Range on Protein: 1883-2159
Range on HMM: 9-279/288.0
FhEHVQEMHVDSDKGFEMEYKSV-PMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFW
  ..|.... .. .||. ||.|. ... . | ..||.  |..|||. || |||. ||||..|. ....||||| ||||...|  |||.||||..|| |||
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RTIWEYRINHIVMLTGVVEGGKKKCEQYWPEkvGENLELPNGFTVTMTSFVQFADYIIRDFKASkaeSDEKDLTVSHYHFTSWPDHGVPQFATSLISFIK
. ..|.... |||||..|||||.|||.|||.  ... ..   .|||...  .  |.. | .       ....|.. .|....|||||||. .. |. ...
elvyenktstivmltelveggktkCeeYWPd..adkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellr

RVQKDHNKDKGvPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELT
 |.  ...| | |..|||||||||||||| || ..|....|. |.| ... .|| .|. .|||. ||.|....| .|.
qvkvanqadtg.piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1884-2157 8.8e-84 275.9 In-house 3-274 (281) alignment 
Range on Protein: 1884-2157
Range on HMM: 3-274/281.0
HEHVQEMHVDSDKGFEMEYKSVPM-QTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWR
..|..... ....|| .||...   ... .    ... |..|||. ||. || .|||.|.     ..||||| ...||. .  |||.|||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

TIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVgENLELPNgFTVTMTSFVQFADYIIRDFKASKAESDEKdlTVSHYHFTSWPDHGVPQFATSLISFIKR
 .||.... |||.|  .|.|| || .|||..  ..|.. . .||..|.  . | || | || .. .....  .|.. ..|.|||||||. .. |..| | 
mvweqkvsaivmvtreieagklkChrYWPddn.selkygd.vtvkstaeeekatyierkfkleresgetr..eveqlaytaWPdhGvPattkellefrke

VQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQE-ESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
|.| ..|.. .||..|||||||||||.| || .......| |...| .|...|| .|..|||| .|| |.. |. .
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_PTPN9_pd Subfamily PTPN9 1884-2157 3.3e-78 257.7 In-house 7-288 (297) alignment 
Range on Protein: 1884-2157
Range on HMM: 7-288/297.0
HEHVQEMhvdSDKGFEMEYKSVP-MQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWR
 ..|.|.     .|   ||. .  ...|  |.  .  .| .|||....  || .||.|..... . |||||| ..|||..|...||.||||. || ||||
vayvkek...gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

TIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNgFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFIKR
 .|| ..  ||| | ||| |. || ||||.. ..  |  . ..|.  . ..  || .| ....... .|.  .|.|. |.||||.|||. |.||. ... 
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgd.lsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlek

VQK------------DHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
|..            .. . .| |..||||||.||||||| ||| ..||.... ..| |....||..| ...||. ||.| . |. |
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN23_pd Subfamily PTPN23 1885-2154 2e-60 199.0 In-house 4-275 (288) alignment 
Range on Protein: 1885-2154
Range on HMM: 4-275/288.0
EHVQEMHVDSDKGFEMEYKSVPMQTET---SFDIGRNEGNKTKNRFANIFPYDFSRVKLTelpgVPDSDYINACYIDGYN-RKDCYIAAQGPLPSTVADF
|..|.  .|   ... ..| . .. .    .. |   . . .|||. .|.||| .||||         |||||... .      ..||.|.||.||..||
eelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNgFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFI
|. ..| . . ||||.   | ||.|...||||. ||  . .. ..||. |  .   .. |..| .  ..|..  .||| ..||||..|||.   .|. |.
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfl

KRVQK---DHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESI-NVYEVLRQLRSKRMYMVQTQAQYVFLHDA
. |..    ...   .||.|||||||||||.| ..   .  |.... . .. .|...|| .| .|||...|. |. .|
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_PTPN6_pd Subfamily PTPN6 1889-2156 6.1e-75 247.0 In-house 19-294 (306) alignment 
Range on Protein: 1889-2156
Range on HMM: 19-294/306.0
EMHVDSDKGFEMEYKSVP---MQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTeLPGVPDSDYINACYIDG--YNRKDCYIAAQGPLPSTVADFWRT
| .  . .||| |....    ...  | . |.   ||.|||. ||.|.| .||.|.  |.||.|||||| ||..   . . .|||.|| |..||.|||| 
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLelPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRV
.|.   . |||.|  || ||.|| .|||..  ..       .||..|  . ||||.|... || .....  .| .|||.||||||||.    ...|.. |
vwqensrvivmttkevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

QKDHNKDK---GVPLMVHCSAGVGRTGTFIMLDIMMDRLKQE---ESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALD
.. ... .     |..||||||.|||||||..||... ....     |..... ...|. |  .|||..|| |.. |. 
nrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1889-2164 4.5e-62 204.5 In-house 9-298 (301) alignment 
Range on Protein: 1889-2164
Range on HMM: 9-298/301.0
EMHVDSDKgFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPG--VPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWE
.. . |.| || .||..  ... | ..| .| ||. ||| || .||  |. |.. |   .   .|||| |||||..|  .||||||. .|..|||| ||.
vaakhsnk.feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

YRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFK--------------ASKAESDEKDLTVSHYHFTSWPDHGV-PQ
..  .|||.|.  || |.|||||||.   |. |    ||||...   . |..||...                | .|| .  .|  .. |.||..|| ..
ekpvsivmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

FATSLISfIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDT
 .| | . |  | .  .|  | |..||||..|.|.|... ..| ..  | |  ..|..| . .| ... .|.|  ||....|..|.  .. .|
prtvLqv.iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
0047943 (Phosphotyrosine protein) phosphatases II 1891-2155 1.8e-90 298.4 In-house 7-268 (273) alignment 
Range on Protein: 1891-2155
Range on HMM: 7-268/273.0
HVDSDKGFEMEYKSVPMQT-ETSFDIGRNEGNKTKNRFANIFPYDFSRVKLtelpGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRI
. .. .....|.. .. .. . .. ... . ||.|||. .|.||| |||||    | ..|||||| |.||||.|  .||.|||||.||.|||| .||...
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

NHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEkDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNK
..||||| .|| |..||.||||...||. .  . ||||..|  ...||..| .. .. ...|  .|| |.|.|.|||||||.  .||..||. |.| ...
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalea

D-KGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
. .. | .||||||||||||||.||...|.|. |  ..|.|....|||.|..||||  ||.||..||
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
subfamily_PTPN14_pd Subfamily PTPN14 1891-2155 3.2e-61 201.9 In-house 19-292 (300) alignment 
Range on Protein: 1891-2155
Range on HMM: 19-292/300.0
HVDSDKGFeMEYKSVP-MQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVpDSDYINACYIDGY--NRKDCYIAAQGPLPSTVADFWRTIWEY
.... | | .||  .| ..... .. .... |. |||| .. ||. .||.|.      ...||||  |      ..  ||.|||||. || |||. .|| 
kleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeq

RINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNGFTVTMTSFVQFAD-YIIRDFKASKAESDEkDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQK-
 .. |||||   |.||.|. .|.|..  .. ..  |    .| |.. .| .| . .|     | | . || |  .| |||||||.  .. .|....||  
gvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske.ertvwhlqytDWpdhgvPeDvkgflsyLeevqsv

--DH-----NKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
         .|..  |..|||||||||||  |. |...  |...|.|.. .||..|| .||..||| ||| |....|
rrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1893-2157 1.6e-44 146.9 In-house 3-257 (267) alignment 
Range on Protein: 1893-2157
Range on HMM: 3-257/267.0
DSDKGFEMEYKSVPMQTETSFDIGR--NEGNKTKNRFANIFPYDFSRVKLTELpgvpDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRIN
|... .| |.. .   ..||  |     | |. .||. .  ||| .|| | .     . .|||| |..||..|  .|. |.||  |..||.  | .... 
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

HIVMLTGVVEGgkkKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFKASKAEsdEKDLTVSHYHFTSWPDHGVPqfATSLISFIKRVQKDHNKD
 ||.|| | ..   .  ..|| |.|.  .  . .||  .   .  || |  ..    .  |    |. |..  |           |  ..  . |.. ..
vivlltkvftd...nirlfwPPkmgqakky.qdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwnintnn..kpylkplfgilaknqlen

KGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
 . ||.|.||.||||.|||...| ...|.|.|.  .... ||..||.|. .|.|. .|...|. | |
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1896-2157 2.9e-71 234.8 In-house 5-266 (274) alignment 
Range on Protein: 1896-2157
Range on HMM: 5-266/274.0
KGFEMEYKSVPMQTetSFDIGRNEGNKTKNRFANIFPYDFSRVKL-TELPGVPDSDYINACYIDGYNRK-DCYIAAQGPLPSTVADFWRTIWEYRINHIV
| .| |. ..|.    . .  .  |..||||. .|.| . ||| | .| .  .||.|||| || ||...  .|.|.|||||.||||||| |.. ... ||
kdlekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLTGVVEGGKKKCEQYWPEKVGENL-ELPNGFTVTMTSFVQFADYIIRDFKASKAESdE-KdltVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDK
||| . |  ..||..|.|.. . .. |  ... ..... |.  || .| .  ...|. | .   | || .|.|||| .|. |..|..... |........
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ers...vkhywytdWPdhksPddantlldlvleveesreeen

GV--PLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
    | .||||||.|||| ||  .| . .|..|. ..| ..  .|| .|  ||||. || ..| || .
aklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_CG7180_pd Subfamily CG7180 1896-2162 6.6e-57 187.4 In-house 17-293 (296) alignment 
Range on Protein: 1896-2162
Range on HMM: 17-293/296.0
KGFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVML
  ...|.| .|  .      | .. |. |||  .. |||. || |..| |  .|||||| |.|.. .|  ||  ..|  .|| .||| ...  |. .|.|
veyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvL

TGVVEGGKkKCEQYWPEKVGENLelpNGFTVTMTSFVQFADYIIRDFKASKA---------ESDEKDLTVSHYHFTSWPD-HGVPQFATSLISFIKRVQK
| . .  | .. .|||.|  |.      . | ...  |.|.  || ||  |          . . .  .| ....| |.  . ||  ...|| ...||..
tktfdfak.mypsywpnkskeqy...geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

DHNK----DKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCG
  .|    ..  |..|..| |..|.| .. .|. .. ...|| ..|.| ...|| .|  .|..  .| .. | | |   |.
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1896-2154 9.1e-44 144.6 In-house 19-266 (288) alignment 
Range on Protein: 1896-2154
Range on HMM: 19-266/288.0
KGFEMEYKSVPMQTETSfDIGRNEGNKTKNRFANIFPYDFSRVKLTelpgvPDSDYINACYI-DGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVM
.| . ||.  | ..     |    .| |..|. |..  |..||||.      |.|.  |. .    . |   | || || .|.  .|. . |  ...|||
eglkkeyrdspneasid.iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

LTGVVEGGKKKCEQYWPEKVGENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDlTVSHYHFTSWPDHGVPQFATSLISFIKRVqKDHNKdkgvP
|. ..| ||.| ..|.| |.||.  .    ||.  . ..    .       . | .||   | . |.  |.|.|||.   | . ..... |...|    |
lcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl.kslqk....P

LMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDA
..||.|||||||||.|.  |... |. .. . . ..| .|| .|.  .||. ||...|  
ivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrc
0046845 (Phosphotyrosine protein) phosphatases II 1897-2161 5e-93 306.8 In-house 1-276 (284) alignment 
Range on Protein: 1897-2161
Range on HMM: 1-276/284.0
GFEMEYKSVPMQTET---SFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGV-PDSDYINACYIDGY-----NRKDCYIAAQGPLPSTVADFWRTIWEY
|.| |.. ....| .   |..... . |..|||. .|.||| |||||. |.|  .||||||| |.|||     ..|  .||.|||||.||.|||| .||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RINHIVMLTGVVEGGKKKCEQYWPEKvGENLELpNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDH
....|||||. || |..||.||||.. || |.. ..||||..|  .. ||..| .. .. . ... .|| |.|.|||||||||. ...|..|.. |.. .
nvrvIVmltelvengrekcaqYwple.gevlty.gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

NK-DKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEE---SINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTC
.. ..| | .||||||||||||||.||.....|..|.    ..|.|....||..|..|||| .||.|...|| |.  .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1897-2153 1.2e-32 107.7 In-house 28-284 (310) alignment 
Range on Protein: 1897-2153
Range on HMM: 28-284/310.0
GFEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTeLPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLT
|.  .|. .  . ..|.     . .  |||....   | |||||. .      ||| | |.     .. .| .||||  |. |||| |.. | . |..| 
glvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

GVVEGGKKKCEQYWPEK-VGENLELPNG--FTVTMTS--FVQFADYIIRD-FKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHnkd
 |.| |. ||  |||   | |         .. .      ...|  .. |     .  .. |.| ||  ..  ||| |||.     .      |  |   
kvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh...

kgVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHD
   | .||||||..|... . |.. .|.|.. . ... ||  .|. .|.  .||. ||.... 
..gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
DSPc_SM00195 1898-2157 6.6e-86 283.2 In-house 2-260 (263) alignment 
Range on Protein: 1898-2157
Range on HMM: 2-260/263.0
FEMEYKSVPMQT-ETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLT
...|.... ..| ..... .. . ||.|||. ||.||| .||||.. .. ..|||||| ||.|.|.|  |||.||||||||.||||..|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GVVEGGKKKCEQYWPEKVGENLELPnGFTVTMTSFVQFA-DYIIRDFKASKAESdEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDkGVPL
  .| ||.||..||||. |.. .    ..|....  .   ..|.|... .| .  |.. .| .|....|||||||. ..|...... |.|....   .|.
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

MVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
.|||||||||||||...||....|..|. ... |....||..|. ||||..|| |...|. |
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 1898-2157 6.6e-86 283.2 In-house 2-260 (263) alignment 
Range on Protein: 1898-2157
Range on HMM: 2-260/263.0
FEMEYKSVPMQT-ETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLT
...|.... ..| ..... .. . ||.|||. ||.||| .||||.. .. ..|||||| ||.|.|.|  |||.||||||||.||||..|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GVVEGGKKKCEQYWPEKVGENLELPnGFTVTMTSFVQFA-DYIIRDFKASKAESdEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDkGVPL
  .| ||.||..||||. |.. .    ..|....  .   ..|.|... .| .  |.. .| .|....|||||||. ..|...... |.|....   .|.
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

MVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
.|||||||||||||...||....|..|. ... |....||..|. ||||..|| |...|. |
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1898-2232 1.1e-81 269.5 In-house 20-349 (515) alignment 
Range on Protein: 1898-2232
Range on HMM: 20-349/515.0
FEMEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTG
|  |.. .|        . ..| | .|||. ||.||| .||||  .   |.|||.|| || ...   .|||.|||....| |||| ......  |.|.| 
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

VVEGGKKKCEQYWPEKVGENLELPNgFTVTMTSFVQFADYIIRDFKASKAESdekDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKgVPLMV
  || | || .|||.| |. ... . . | . |    .. |.| ..  | .      ||  .||| |||.|||. ..||. .|| |. ||.. .  ||..
lkegdkikcgkyWPdkpgdsvkfGs.ikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hplii

HCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLRARVNKMHKMIPGKNITGFQEQYELL
|||||||||| .| .| .. . |. ....|.......| ||.|.|||| || |...|. |     .| |    .   .. .|    |.  . . .... |
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtl

DQVGYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMH
  .   |       | |  | ||||| . .||.  
kslcpdppasqtrsgrtrdnhpknrygnnlplqrn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1898-2155 2.8e-33 109.8 In-house 13-265 (281) alignment 
Range on Protein: 1898-2155
Range on HMM: 13-265/281.0
FEMEYKSVPMQTETSFDIGRN-EGNKTKNRFANIFPYDFSRVKLTE-LPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVML
|. |.  .| .  . .    |   |. |||..||   | |||.|   .|    .||| | ||     |  || .|||   | ||||| ||.     ||||
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFKASKaESdEKDlTVSHYHFTSWPDHGVPQFATSLISFIKRVqkdhnKDKGVPL
  ..|  ..|| .|.| .    |.. . ..|.          .   .. |  |  |    ..|. .  |||  ||. .  ..  ....     . .  | 
cqfletnrekcaeyfprnahcclqf.dklsvsyedstvnkslvttrlnlsy.eg.etr.lithwlwkewpdwqvpessevmlkilrki.....rarstpp

MVHCSAGVGRTGTFIMLDIMMDRLKQEESI-NVYEVLRQLRS-KRMYMVQTQAQYVFLHDAL
..||||||||.||.. ..| .. ..   .. .. ... .||   |   |||  ||...   |
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
0045098 (Phosphotyrosine protein) phosphatases II 1900-2162 3.2e-83 274.6 In-house 12-275 (278) alignment 
Range on Protein: 1900-2162
Range on HMM: 12-275/278.0
MEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKltelpgvpdsDYINACYIDGYnrKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVV
. .  ...    ..  .  .||. |||. .|.|||.||||          ||||| |||||  .. .||.|||||||||||||..||..|..|||||..|
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EGGKKKCEQYWPEkvgENLELPNGFTVTMTSFVQFADYIIRDFKASKA---ESDEKDLTVSHYHFTSWPDHGVPQFA--TSLISFIKRVQKDHN------
|.|..||.|||||   .. .  ..||||..|. .. ||..|...       ..| . ..| |.|...||||||| .   .|.......... ..      
elgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

------KDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLkqEESINVYEVLRQLRSKRMY-MVQTQAQYVFLHDALDELTTCG
       |.| |  ||||||||||||......|...|  |. ....|....|||.|.. .||.. ||.||...| ||  .|
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1900-2155 4.5e-47 155.5 In-house 20-273 (307) alignment 
Range on Protein: 1900-2155
Range on HMM: 20-273/307.0
MEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTeLPGVpDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVV
 |.. .  .|  .  .   . |  |||. ..   | .|. .. ..|.  |||| | |.    .   .|.||||| .|. .||  . . ... ..||  |.
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EGGKKKCEQYWPEKVGENLE---LPNGFTVTMTSFVQFA-DYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkdkgvPL
| .| ||||||| . |..|     ||  .|.     ..| |  . .  . | .  .|  |..|. .. |||.||||   . | ... |. |.|     |.
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pv

MVHCSAGVGRTGTFIMLDIMMDRLKQE-ESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
.|||||||||.|| . . ...|.. .  .  .. .....|||.| | .||.|||..||  |
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
0049772 (Phosphotyrosine protein) phosphatases II 1900-2157 2.6e-46 154.2 In-house 25-278 (314) alignment 
Range on Protein: 1900-2157
Range on HMM: 25-278/314.0
MEYKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDfSRVKLtELPGVPDSDYINACYIDGYnrkDCYIAAQGPLPSTVADF----------WRTI--WEY
. . |  . .| .. ... . |..|||. .|.|.| .||.|    .| .|||||| |.||.     .||.||||. || ||          || .  ...
lnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdl

RINHIVM---------------------LTGVVEGGkkkceQYWPEKVGENLElpngftvtmtsfvqfadyiirdfkasKAES--DEKDLTVSHYHFTSW
..  |||                     |... ..|      .....  |.|.                          .     .    .. .|. . .
nvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..........................eelydpelferlgikylripv

PDHGVPqFATSLISFIKRVQKDhnkDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLkqeeSINVYEVLRQLRSKRM-----YMVQTQAQYVFLHDALDE
||...|     . .|.. ...    ||| |. |||.||.||||||. ....| .|     ... |.|...|.||.      ..... ||.| ..|| |
pDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_CG42327_pd Subfamily CG42327 1901-2084 2.5e-28 93.6 In-house 10-191 (319) alignment 
Range on Protein: 1901-2084
Range on HMM: 10-191/319.0
EYKSVPmQTETSFDiGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDC-YIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVV
|.. .| |  .. |     . | |.|..|. |   .|| | . .  . . |..| |. ||.  .. ||||| .| .. .|||||.|| .   || || . 
efrdlP.qliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

EGGKKKCEQYWPEKV-GENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEkDLTVSHYHFtSWPDHGVPQFATSLISFIKRVQ
| | |.| .|.| |  ..| .|   . ||.        |.|  .   . . .|    ..|| .  |.. .||   ..||. . .|.
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1902-2157 7.3e-72 236.6 In-house 1-262 (270) alignment 
Range on Protein: 1902-2157
Range on HMM: 1-262/270.0
YKSVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKD-CYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVE
.| .. ..... |.     .|. ||.|.| |   .||.| ||   . . |||| |. |.. ..  ||||.||||.|. .|||.||| . . |||.||..|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

GGKKKCEQYWPEKVGENLELPNGFTVTMTSF-VQFADYIIRDFKASkAESDEKDLTvsHYHFTSWPDHGVPQFAT------SLISFIKRVQKDHN-KDKG
 |.||||.|||....|...| .|.  ....  ..   ||..  .    ...|. |.  |.....|||||||. .       .|.. .. |.. .. .||.
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

VPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
 ||.||||||||||||.|.|||..  |.......| .....|| .|| .||.  || ||. |. |
ePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN13_pd Subfamily PTPN13 1902-2155 1.8e-70 232.4 In-house 17-265 (273) alignment 
Range on Protein: 1902-2155
Range on HMM: 17-265/273.0
YKSV-PMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGvpdsdYINACYIDGYNRKDC--YIAAQGPLPSTVADFWRTIWEYRINHIVMLTGV
.| .  ...  . ..|... ||.|||. |..||| .|||| .  |     |||| .|     ||   |||.||||| ||.|||. .|| . . |.|.|  
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VEGGKKKCEQYWPEKVGENLELPNGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkdKGVPLMVH
.|.|| ||..||||. ...| . | ..|..   ..  .. .|... .. || |    |.| .|..|||||||. |..|. |...|.. ..  .  |..||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
||||.||.||.| .|.... ........| |..|.|| .|  .|||. ||.| . |.
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1902-2156 9.5e-46 150.7 In-house 35-280 (290) alignment 
Range on Protein: 1902-2156
Range on HMM: 35-280/290.0
YKSVPMQTETSFDIGRNEGNK--TKNRFANIFPYDFSRVKLTElpGVpDSDYINACYIDGYNrkDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVV
 | .|      ..    . |   .|||. ..   | .|| | .  |  | ||. | |..| .    .| .||.| .|| |.|| . . ..  ||||  ..
eklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gy.dGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceli

EGGKKKCEQYWPEKVGENLELPNgFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKdhnkdKGVPLMVHC
| || |||||.||| || | . . .||. .   .  . ||.   . .   . |.  . |..  ||||. |.. . .|.  .. ..|        |..|||
edGkakceqyypekeGevltfGe.itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.....asGpvvvhc

SAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALD
|||.||||||. ... .. | .  .... .. | ||  |.  || . ||. | ..| 
saGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
0036941 (Phosphotyrosine protein) phosphatases II 1904-2164 1.5e-91 302.1 In-house 22-282 (297) alignment 
Range on Protein: 1904-2164
Range on HMM: 22-282/297.0
SVPMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLtelpGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGK
 .|..   |........|..|||. .|.|||..||||    . ..||||||.|.|||..|  .||.|||||.||.|||| .||.....||||| .|| |.
llpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

KKCEQYWPEKVGENLELpNGFTVTMTSFVQ--FADYIIRDFKASKAESDeKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKD-KGVPLMVHCS
.||.||||...|| |.  ..||||..|. .  ..||..| .. .. ... . .|| |.|.|.|||||||. ..||..||..|.| ...  .| | .||||
ekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGVGRTGTFIMLDIMMDRLK---QEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDT
|||||.||||..|.|...|.    |. ....|....||..|. .|||  ||.||..|| ||  ...|
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1904-2172 8.7e-60 197.0 In-house 19-279 (283) alignment 
Range on Protein: 1904-2172
Range on HMM: 19-279/283.0
SVPMQtetSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGvpdsDYINACYID---GYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVE
||| .   . ||  .. ||.|||. .| |.|  ||.|  ..     |||||..|     |...  ||.||.||  || |||. ... .|  ||||| . |
svpdl...dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

GGKKKCEQYWPEKVGENLelpNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFiKRVQKDHNKDKGVPLMVHCS
. ..|| ||||..  |.      ||||.   .    .||. .   .  | .. | ..|| .  | . |      ||. |  .|.   .. |  |..||||
dlrikCsqyWPkrGsedy...GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgPivvhCs

AGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSNLR
.|.|||..|| .   .. .. |  ..|..|.. .| .|| .|||. || ..|..  | . |||| |.  .| 
tgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlq
subfamily_PTPN12_pd Subfamily PTPN12 1906-2159 4.6e-80 263.6 In-house 25-277 (290) alignment 
Range on Protein: 1906-2159
Range on HMM: 25-277/290.0
PMQTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKK
 .... | . |..| |..|||. .|.|||.|||.|..  ....|||||| .| | . |  ||||||||| |. |||| |||.... .||.  .|| ||||
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CEQYWPEKVGENLELpNGFTVTMTSFVQFA-DYIIRDFKASKAesdEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkDKGVPLMVHCSAGVG
||.||||...|.||  . |.||...  ..  |..|| .|. .    ..  .|  .|.|.|||||||. |.||...|. |.. .. .. .||.||||||||
CerYWpeegeeelef.gefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvG

RTGTFIMLDIMMDRLKQEES---INVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELT
|||| | .|.. . ||.|     ..|......|| .|  .|||. ||.... |. || 
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1908-2154 7e-43 141.4 In-house 41-284 (305) alignment 
Range on Protein: 1908-2154
Range on HMM: 41-284/305.0
QTETSFDIGR-NEGNKTKNRFANIFPYDFSRVKLTELPgvpDSDYINACYIDGYN-RKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKK
 |.. |.  . .. ..||||....   | | ||| . .    |||| | |.      .  .|.|||||  |. .||  . . ....||||   || || |
mtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

CEQYWPEKVGENLELPNGFTVTMTSFVQFA--DYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHnkdkgVPLMVHCSAGV
| ||||   ||.||| .|  |   |  .    |  |.      . | .. ..| | ..| ||| |||    . . ..  ..  .     ||..||||||.
caqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagi

GRTGTFIMLDIMMDRLKQEES-INVYEVLRQLRSKRMYMVQTQAQYVFLHDA
||||| . .. ..... .. .   . |... || .| . .|.. ||.|.|  
grtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrv
subfamily_egg_pd Subfamily egg 1908-2154 6.3e-30 98.9 In-house 27-265 (307) alignment 
Range on Protein: 1908-2154
Range on HMM: 27-265/307.0
QTETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGgkKKCE
  | |.    .. |..| |   .   |.|||||    |    |.| | ...|    . .| || ||  || |||| ... ....|||||  .|   ..||
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPEKVGENLEL-PNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTsWpdhgvpQFATSLISFIKRVQKDHNKDKgvPLMVHCSAGVGRT
 |||    ..| . | .. ..     . || . |  |     .|.... . |.    .      .... . | .. ..|  |  |  | .|..  || ..
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.v......nnssdvysplrvlrklrnlsk..pvvvqdilGvska

GTFIMLDIMMDRLKQEeSINVYEVLR---QLRSKRMYMVQTQAQYVFLHDA
.|.. ..| .  | .   |  . |||    || .| . |..  .|.|..  
atlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrl
subfamily_PTPRN_pd Subfamily PTPRN 1909-2155 2.8e-57 188.7 In-house 44-288 (297) alignment 
Range on Protein: 1909-2155
Range on HMM: 44-288/297.0
TETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYI-DGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCE
 ... .....| | .||| ....||| |||||.|     .||||||  | |   |. .|||.||||.|||||||...||  .  ||.|| . | | |.|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYWPEKvGEnlELPNGFTVTMTS-FVQFADYIIRDFKASKAESDEkDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKdKGVPLMVHCSAGVGRT
.|||.. |.  |. . . | . |  .   ||..| |     ...|   ||. .|| |||..|||  | ||. | ..|.| .   .  |..||||.|.|||
rywpde.Gs..evyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrt

GTFIMLDIMMDRLKQ-EESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
|..|..|....||..    |..   |  || .|  .|.|..|. |   |.
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_PTPN3_pd Subfamily PTPN3 1910-2155 8.1e-68 223.4 In-house 30-271 (280) alignment 
Range on Protein: 1910-2155
Range on HMM: 30-271/280.0
ETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTElpgvPDSDYINACYID----GYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKK
. . .. |   | .|||. .| |||  ||||.|     ..||||| |..    . .    |||.||||..|..|||. .|| ... ||||| .|| |..|
glaisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CEQYWPEkVGENLELPnGFTVTMTSFVQFADYIIRDFKASKAESDEKDlTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkDKGVPLMVHCSAGVGR
| |||||  ...||.  .|.|....  .   |..|..  ...|..|.  .. .  ...|||||||. ......|..||.| ..  |  |..||||||.||
ChqyWPe.tedeleyg.efsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvvvhCsaGigr

TGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
|| .|.|.. .  . ..|.... ...|..| .|. .|||..|| |. .|.
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1910-2154 2.3e-45 149.8 In-house 22-290 (297) alignment 
Range on Protein: 1910-2154
Range on HMM: 22-290/297.0
ETSFDIGRNEGNKTKNRFANIFPYDFSRVKLTElpGVPDSDYINACYIDGYNRKD--CYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCE
  ||   . ..   |||. .|. .| .||||    .....||||| |.   . .    || ||||| .|| |||. ..|  .. |||.. . |.|..|| 
gesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

QYWPEKVGENLELPNGFTVTMTSFV-QFADYIIRDFKASKAesdEKDLTVSHYHFTSWPDHGVP-------QF-------------ATSLIS------FI
 |||. |.|.|. ..     ..|.  .|   |. ...       ..   | |  | ||||||||       .|               .|.       |.
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvfl

KRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDA
.      .. . ..|.|||||||||.|  .. |.....|...   .|  .|..||..|  .|||  |. .|.||
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_PTPN1_pd Subfamily PTPN1 1911-2157 3.6e-58 191.6 In-house 22-269 (290) alignment 
Range on Protein: 1911-2157
Range on HMM: 22-269/290.0
TSFDIGRNEGNKTKNRFANIFPYDFSRVKLTElpgvPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYW
 .    ... |...||. .. ||| ||.|| .     | |||||  ..  . |  || .|||||.||. ||. .|| .   .|||  ||| .. || |||
fptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PEKVG-ENLELP-NGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDH--NKDKGvPLMVHCSAGVGRT
|..   ..|.|    ..|.. |  .   |..| ..  . ...|   ...|.|.|.||| |||.  .....|. .|..    ..|.| | ..|||||.||.
Pqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssdvG.pavihcsaGiGrs

GTFIMLDIM---MDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
|||...| .   ... .. .|... .|| .||. |. ..||. |  | . |. |
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1912-2156 4.4e-56 184.8 In-house 29-274 (287) alignment 
Range on Protein: 1912-2156
Range on HMM: 29-274/287.0
SFDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVpDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWP
 |    .  .  |||.|...|.| .|| |.. .    |||||| |. .|.... .||||||...|| |||| ..| |   ....|  || ...|| .|||
tfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

EKvGENLELPnGFTVTMTSFV-QFADYIIRDFKASKAESDEKDLtVSHYHFTSWPDHGVPQFATSLISFIKRV----QKDHNKDKGVPLMVHCSAGVGRT
|.    . .  |..|.. ..  .  .| .| ..  ..|. |  . |  ... ||||....  | .|| |.  |    .   . ..  ||.||...|.||.
er.evPmrvG.GysvvlldydikePeygvralrlidletrearv.vkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALD
|... . ....||..   ..|  |. .|| .|  .||.  |. .| .|| 
GillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0040439 (Phosphotyrosine protein) phosphatases II 1913-2158 6.9e-86 283.1 In-house 3-245 (249) alignment 
Range on Protein: 1913-2158
Range on HMM: 3-245/249.0
FDIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPE
..... . || |||. .|.|||.|||||. |||...|||||| |||||..|. .||.|||||.||.|||| .||..|..|||||  || |..||.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

kvgENLELPNGFTVTMTSFVQFADYIIRDFKASKAeSDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKD-KGVPLMVHCSAGVGRTGTFIM
   ..    ..||||..|. ...||..| .. ..   | ...|| |...|.|||||||..  .|..||..|.| .... || |..||||||||||||||.
...ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDEL
...|...|. |  ....|....|||.|...||.. ||.||..|| ||
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 1914-2155 1.3e-83 275.4 In-house 2-239 (245) alignment 
Range on Protein: 1914-2155
Range on HMM: 2-239/245.0
DIGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEk
.... . ||.|||. .|.|||..||||.. .| .|||||||.|.|||.... .||.|||||.||.|||| .||..|..|||||  .| |..||.||||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

vgENLELPNGFTVTMTSFVQFADYIIRDFKASKaESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLD
  ..    ..||||..|. ...||..| .. .. . | . ..| |||...|||||||    .|..|...|.|  ..|.. |..||||||||||||||...
..gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

IMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
.|...|. |  ....|....|||.|. .|||. ||.||..||
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1915-2161 6.5e-80 262.9 In-house 3-244 (250) alignment 
Range on Protein: 1915-2161
Range on HMM: 3-244/250.0
IGRNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKkCEQYWPEKV
....  || |||.|.| ..| ||| | .  |  .|||||| ...||. .. .||.||||..|. |||| ..|. .. ||||| ..| .|. ..|||| ..
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

GENLelpNGFTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDI
 |.     . ||.. |  .||||..| .| |||.  ..  .| ..||..||| |||. ||. . ..|.||. ... .  |..|.|||||||.|.|| .| 
aeky...Gdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

MMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTC
...|||.|. ..|..|...|| .|. .|....||||.. .. . ...
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0037934 (Phosphotyrosine protein) phosphatases II 1915-2157 6.2e-77 253.7 In-house 4-240 (243) alignment 
Range on Protein: 1915-2157
Range on HMM: 4-240/243.0
IGRNEGNKTKNRFANIFPYDFSRVKLtelpgvPDSDYINACYIDGYNRkdcYIAAQGPLPSTVAD----FWRTIWEYRINHIVMLTGVVEGGKKKCEQYW
|.. . |..|||. .|.|||.|||||      ..|||||| .|....|   .|| |||||.||.|    ||| .||..|..|||||  || |..||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PekvgE-NleLPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNK-------DKGVPLMVHCSAG
|    .      ..||||..|. ...||..| .. .  . |.  ..| |||...|||||||.  ..|..|.. |..  ..       |.| |. ||||||
p....gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFIMLDIMMDRLkqeeSINVYEVLRQLRSKRMY-MVQTQAQYVFLHDALDE
||||||.|....|...|    .....|....||..|.. .|||. ||.||..|| |
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1917-2170 5e-83 273.9 In-house 21-266 (284) alignment 
Range on Protein: 1917-2170
Range on HMM: 21-266/284.0
RNEGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTgvveggKKKCEQYWPEKVGE
  . || |||. .|...| ..|||  | |.  |||||| .| || ||| |||.||||. |.||||| ||||..  ||.||      |.|| |||| |. .
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

NLElpnGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKG-VPLMVHCSAGVGRTGTFIMLDIM
. |    | | ..|  . ..|..||.. |.    ..  ..  .||  |||.|||.... |. ..|.|.. ..| ..  ...|||||||||||..|.||..
kee...rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

MDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCGDTSIIGSN
.||.|.|. ..||...|.|| .|  .||  .|| |.. || |    | . .   .
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1918-2068 3.3e-15 50.4 In-house 93-234 (244) alignment 
Range on Protein: 1918-2068
Range on HMM: 93-234/244.0
NEGNKTKNRFANIFPYDFSRVKLTElpGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEggkkkCEQYWPEKvgEN
|  |  ||| .  .|.||.|| |..  |     |||| ..    |   || .| ||  |  |||. . |  .| .|.|  | |      ..|||.   | 
npnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds..ep

LEL-PNGFTVTMTSFVQFadyiiRDFKASKAESdEKDLTVSH-----YHFTSWPDHG
||   .  |||.|   .|     .. |||. |  | |.  ||     .  . ||  |
lewyeeditvtltdrdef.....knikasnlei.esdmneshqaltmfqisnwpsdg
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1919-2155 2.3e-67 221.7 In-house 6-237 (239) alignment 
Range on Protein: 1919-2155
Range on HMM: 6-237/239.0
EGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNR-KDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGEN
  ||.|||.|||  ||.||| | .|   | |||||| |.  |.    .|||.|| .  .  |||| .|. |   ||||||..|| |||| ||||.   . 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

LELpngfTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKdKGVPLMVHCSAGVGRTGTFIMLDIMMD
 .|     ||.     ||||||| |  |.    |.   | .|||| |||.||||.||... . ... ||       | ..||||||||||.|...| |. 
cnl....rvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlr

RLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
. |......... .. .|  | .||||  ||||.| |.
qakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1919-2155 5.3e-41 135.3 In-house 46-283 (305) alignment 
Range on Protein: 1919-2155
Range on HMM: 46-283/305.0
EGNKTKNRFANIFPYDFSRVKLteLPGVPdSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENL
  .. |||. ..   |  ||||   .  |  .|| | |.        .| .| ||  | ||||   .. ... | ||  ..| | ||| .|.. | .. |
aqeagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

ELPNG---FTVTM-----TSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQkdhnKDKGvPLMVHCSAGVGRTGTFI
|. ..    .| .      .|.. |.  ... .     . || . |.|||.  ||| |||   .... .... .      || |..||||||.||||. .
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskg.pivvhcsagigrtgsvv

MLDIMMDRLKQEESINVY-EVLRQLRSKRMYMVQTQAQYVFLHDAL
||. ..|.| . . |.    .|...| .|   .||.|||.|.|. .
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1919-2157 3.4e-40 132.8 In-house 33-268 (285) alignment 
Range on Protein: 1919-2157
Range on HMM: 33-268/285.0
EGNKTKNRFANIFPYDFSRVKLTElpgvPDSDYINACYIDGYNR-KDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGEN
| |   ||.|..   . .|| | .     | ||| | ..    . .  ||..||||| |..|||. |.. .| ...||  ..||| .||  |.|||.|| 
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

LELPNgFTVTMTS--FVQFADYIIRDFKASKAES-DEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKgvPLMVHCSAGVGRTGTFIMLDI
... . . .|.|       |  |.  .   ..|    . | . | .   |||.  |. |  .| . | |.|   |.|  |. |||||||||| ||. .| 
vkfgk.yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek..picvhcsagvgrtatfvgidy

MMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
   |. ..  |.. ...|..|. |.  ||.. |..||.  | |
atirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_eak_pd Subfamily eak 1919-2097 5.3e-14 46.3 In-house 50-216 (332) alignment 
Range on Protein: 1919-2097
Range on HMM: 50-216/332.0
EGNKTKNrFANIFPYDFSRVKLTELPGVPDsDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENL
  .  .|   .| |||.  |.||     ..  ||||  ..  .    || .  .  . |  ||. . | .   ||.|   || . .| ..|.|.|  |.|
leavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

ELPNgFTVTMTSFVQFADYIIRDFKASKAESDEKdltVSHYHFTSWPDHGVPQFATsLISFIKrVQkdhnKDKGVPLMV
.    . |.  .||. . .  | .. || .   .   | ||..  | .  .|..   .... | |     |. ||.|..
kfGi.ldverkefvkrniletrllelskGnethr...vlhykvfGwtettlpkyed.flalrk.vm....kevGvllli
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1919-1995 2e-07 24.8 In-house 35-116 (347) alignment 
Range on Protein: 1919-1995
Range on HMM: 35-116/347.0
EGNKTKNRFANIFPYDFSRVKLTE-----LPGVPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVML
| . .|||  .    | .|| |.       .  .   |||| .|   | .  || .| |||.|| |||. .   ..  .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1919-2073 8.6e-07 22.0 In-house 25-158 (169) alignment 
Range on Protein: 1919-2073
Range on HMM: 25-158/169.0
EGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINAcyidgynrkdcyiaaqgplpstvadfwRTIWEYRINHIVMLtgvveGGKKKCEQYWPEKVGENL
  |.|||| |  .   . ||||  .     ||||||                           | |||     ||.|     |.    ...||||   .|
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpekedyql

ELP--NGFTVTMTSFVQ------FADYIIRDFKASKA-ESDEKDLT--VSHYHFTSWPDHGVPQFA
      |   | . .|.       .. .   |. |    | ..|.|  .| .|...||. ||||  
hpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqsp
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1919-2073 2.1e-06 20.7 In-house 24-157 (169) alignment 
Range on Protein: 1919-2073
Range on HMM: 24-157/169.0
EGNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINAcyidgynrkdcyiaaqgplpstvadfwRTIWEYRINHIVMLtgvveGGKKKCEQYWPEKVGENL
  |.|||| |  .   . ||||  .     ||||||                           | |||     ||.|     |.    ...||||   .|
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpekedyql

ELP--NGFTVTMTSFVQF------ADYIIRDFKASKA-ESDEKDLTV--SHYHFTSWPDHGVPQFA
      |   | . .|.       .  .   |. |   .| ..|.|.  | .|...||. ||||  
hpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqsp
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1920-2155 2.3e-67 221.6 In-house 6-236 (239) alignment 
Range on Protein: 1920-2155
Range on HMM: 6-236/239.0
GNKTKNRFANIFPYDFSRVKLTELPGVPDSDYINACYIDGYNR-KDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENL
 ||.|||.|||  ||.||| | .|   | |||||| |.  |.    .|||.|| .  .  |||| .|. |   ||||||..|| |||| ||||.   .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

ELpngfTVTMTSFVQFADYIIRDFKASKAESDEKdLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKdKGVPLMVHCSAGVGRTGTFIMLDIMMDR
.|     ||.     ||||||| |  |.    |.   | .|||| |||.||||.||... . ... ||       | ..||||||||||.|...| |. .
nl....rvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrq

LKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
 |......... .. .|  | .||||  ||||.| |.
akkqktvdifnyvkairedrphmvqtseqyvfihlav
Y_phosphatase Protein-tyrosine phosphatase 1921-2155 7.2e-83 273.0 Pfam-A 1-233 (235) alignment 
Range on Protein: 1921-2155
Range on HMM: 1-233/235.0
NKTKNRFANIFPYDFSRVKLtelPGVPD-SDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLE
||.|||. .| |||..||||    | .. |||||| |..||..|  .||.||||.||..|||| .|..... ||||| ..| |..||.|||||. .| |.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

LPNgFTVTMT-SFV-QFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHnKDKGVPLMVHCSAGVGRTGTFIMLDIMMD
  . ..|... .   . ..|..|... .| .....  .|...|.|.|||||||. ..||...|..|.|.. ..|  |..|||||||||||||..|||...
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
.|..||...|......||..|. |||. .||.||..|.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1921-2155 7.2e-83 273.0 In-house 1-233 (235) alignment 
Range on Protein: 1921-2155
Range on HMM: 1-233/235.0
NKTKNRFANIFPYDFSRVKLtelPGVPD-SDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLE
||.|||. .| |||..||||    | .. |||||| |..||..|  .||.||||.||..|||| .|..... ||||| ..| |..||.|||||. .| |.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

LPNgFTVTMT-SFV-QFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHnKDKGVPLMVHCSAGVGRTGTFIMLDIMMD
  . ..|... .   . ..|..|... .| .....  .|...|.|.|||||||. ..||...|..|.|.. ..|  |..|||||||||||||..|||...
ygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
.|..||...|......||..|. |||. .||.||..|.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1921-2155 2.2e-63 208.7 In-house 3-235 (237) alignment 
Range on Protein: 1921-2155
Range on HMM: 3-235/237.0
NKTKNRFANIFPYDFSRVKLTELPGVpdSDYINACYIDGYNR-KDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvgENLE
|| |||..||  || ||| |    .   ||||||.|..|..     |||||||| |.  |||. .|. .   ||||||..|| ..|| .|||.   .. .
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst..dqpa

LPNGFTVTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNK-DKGVPLMVHCSAGVGRTGTFIMLDIMMDR
    .||...   .|.|| .| .  ||  . ..   .  |.||||||.|||| ...|. | |.. .  ..  .  | ..|||||||||| |...| |. .
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
 |... ...|. .  .   | |..||. ||||.|...
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 1921-2162 7.5e-56 183.9 In-house 1-174 (182) alignment 
Range on Protein: 1921-2162
Range on HMM: 1-174/182.0
NKTKNRFANIFPYDFSRvkltelpgvpDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTgvveggkkkCEQYWPEKVgenlel
|..|||. .|.|||.||          |.||||| ...|. . . .||.||||.||||||.|...|..|..||.||         .|.||||..      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

pngftvtmtsfvqfadyiirdfkaskaesdekDLTVSHYHFTSWPDHGVPQfATSLISFIKRVQKdhnkdKGVPLMVHCSAGVGRTGTFIMLDIMMDRlk
                                  .. .|....|||||||    .|..||..|..     .| |  ||||||||||||......|. .  
................................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl..

qeeSINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDELTTCG
   .....|.....||.|. ||.|  ||.||..|| ||  ..
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1921-2156 1.9e-36 120.6 In-house 47-341 (350) alignment 
Range on Protein: 1921-2156
Range on HMM: 47-341/350.0
NKTKNRFANIFPYDFSRVKLTELPG--------VPDSDYINACYIDGY-----NRKDC-YIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKC
  .|||. ||.||. ||||| . .         .  .||||| |.           |  |||.|.|||||| ||.. | .  .. |..||  || . .||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

EQYWPEKVGEN--LELPNGFTVTM--TSFVQFADYIIRDFKASKAES---------DEKD--------LTVSHYHFTSWPDHGVPQFATSLISFIK----
..||.|   ..  . | .    .|     ....  . ...     .|         .  .        . | . ..  |.| ..     |... ..    
yrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevknd

----RVQKD-HNKDKGVPLMVHCSAGVGRTGTFIMLDIMMD-----RLKQEESIN----------VYEVLRQLRSKRMYMVQTQAQYVFLHDALD
     . .   ..... |..||||||||||||.. || ..      .  ..|| .          .  .. .||..|. |||.  |..|...|| 
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1921-2157 5.7e-20 66.1 In-house 47-277 (303) alignment 
Range on Protein: 1921-2157
Range on HMM: 47-277/303.0
NKTKNRFANIFPYDFSRVKLTelpgvpDSDYINACYIDGYNRKDCyIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKvGENLEL
|  ||||...   | |.|||.      || || | |..   .| . | .| ||. | ||||. | | ... ...|    |  |   .  .|..  . |..
nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkf

PNGFtVTMTSFVQFADYIIRDFKA-SKAESDEKDLtVSHYHFTSWPDHGVPQF-ATSLISFIKRVQKDHNKD-KGVPLMVHCSAGVGRTGTFIMLDIMMD
 . . . .  | .        .|  | .. | | . .  .|. .||   .|   .  ..  | ..|    |  .. | .    .|.||.||| ...    
eers.irvgefkrvelgdgwvlkvlsvsngdyksf.lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RLKQE-ESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
 |..|  |...  .| ..|  |.. ||  .|. ...  | |
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1921-2154 1.1e-19 65.0 In-house 51-280 (302) alignment 
Range on Protein: 1921-2154
Range on HMM: 51-280/302.0
NKTKNRFANIFPYDFSRVKLTELPgvpdSDYINACYIDGYNRKDCYIAAQGPLPSTV---ADFWRTIWEYRINHIVMLTGVVEGGKkKCEQYWPEKVGEN
|  ||.  ..  .|  .|||.. |     .|.||  ..  . .   | || |  ...   ..||| ... .| ..|.| |  |  |   ....|.| |. 
nlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

LELpNGFTVTMTSfVQFADYIIRDFKASKAESDE-KDLTVSHYHFTSWPDHGVPQFATSLISFIKRV-QKDHNKDKgvPLMVHCSAGVGRTGTFIMLDIM
.|  . . |     |. |.     .       .    . .. |..| |... ||.  ..||  .. | .|. . |.  ....    |.|| |.|. | . 
key.gkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade..ntvivSknGaGRagafltlava

MDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDA
...|....  |. |.....||.|  .|..  |||.|. |
veklqkgkepnikeivksiRsqRpravdslkQyvslyia
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1921-2005 7.1e-10 32.9 In-house 34-117 (332) alignment 
Range on Protein: 1921-2005
Range on HMM: 34-117/332.0
NKTKNRFANIFPYDFSRVKLTELPGvpDSDYINACYIDGYNRKDCYIAAQGPLPS-TVADFWRTIWEYRINHIVMLTGVVEGGKKK
|   ||   .. .|.|||.|.   |    |. || ..|||..| .|| || |.   |   ||| . | . . |...  . |  |.|
nmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1922-2155 2.2e-30 100.5 In-house 44-272 (312) alignment 
Range on Protein: 1922-2155
Range on HMM: 44-272/312.0
KTKNRFANIFPYDFSRVKLTelpGvPDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVG-ENLEL
|  ||. ||  .|  |  |.   |  .  || | ..    . . ....|||| .|.. ||.         |..|.|.|| | .|| .|  . ||  .|| 
kdlnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

PNGFTVTMTSFV---QFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkdkgvPLMVHCSAGVGRTGTFIMLDIMMD
   .|   |      .  | |          .  ..  . || ..||||||.|.   .   ..  |.||..     |.. |||||||||||..... |. 
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmia

RLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
 |..    || ...  ||  |   |.. .|||.   ..
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1922-2017 1.6e-15 51.3 In-house 49-160 (349) alignment 
Range on Protein: 1922-2017
Range on HMM: 49-160/349.0
KTKNRFANIFPYDFSRVKLTELPGVP--------------DSDYINACYID--GYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKK
 .|||. .|.||. ||||| . .  .                ||||| |.    .. .  ||| | |||||| ||.. |   ... .. |.   | . .|
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CEQYWPEKVGEN
|..|| |   .|
cdiywqelsysn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1931-2068 3.8e-10 34.2 In-house 3-125 (130) alignment 
Range on Protein: 1931-2068
Range on HMM: 3-125/130.0
FPYDFSRVKltelpgvpDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEggkkkCEQYWPEKvgENLE-LPNGFTVTMT
.....||..        . .|||| ..   .|   |. .| ||  |  |||. . |  .| .|.|  | |      ..|||.   | ||   .  .||.|
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpds..ePlewyeediivtlt

SFVQFaDYIIRDFKASKAESDEKDLTVSHYHFTSWPDHG
   .| ..|  ..   . .  |   ... .. . ||  |
drdef.knikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 1932-2161 3e-43 142.8 In-house 1-173 (178) alignment 
Range on Protein: 1932-2161
Range on HMM: 1-173/178.0
PYDFSRVKLTELPGVPDSDYINACYIDGYnrkdCYIAAQGPlpstvADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGenlelpngftvtmtsf
|.|..||.|..|.|.. ||||||..|...     |.....|     ||... ..|. |.|||.||. .|.|. || .||||. |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vqfadyiirdfkaskaesdekdltvSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkDKGVPLMVHCSAGVGRTGTFIMLDIMMDRlkqeeSINVYEVL
                          .|... .||||||.    .  |.. ... .. .|| |  |||||||||.||......|. .     .....|..
.........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

RQLRSKRMyMVQTQAQYVFLHDALDELTTC
...|..|. .|... |. .|..   .|   
elvrerRp.ivpnpgqlrqLyefelrllke
0046846 (Phosphotyrosine protein) phosphatases II 1942-2158 2.3e-47 156.3 In-house 5-172 (176) alignment 
Range on Protein: 1942-2158
Range on HMM: 5-172/176.0
ELPGVPDSDYINACYIDGYnrkdCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLelpngftvtmtsfvqfadyiird
.|   .|.||||| .|.|.    ..|| |||||.|.|||.. ..|..|...|.||  || |. || .||||  ....                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

fkaskaesdekdltvsHYHFTSWPDHGVPQFaTSLISFIKRVQKDHNKDkgVPLMVHCSAGVGRTGTFIMLDIMMDrlkqEESINVYEVLRQLRSKRM-Y
                .|... |||||||.. . |..... ...  ...   |  ||||||.|||||........     |  ..|.|.|...|..|. .
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplg

MVQTQAQYVFLHDALDEL
.|||..|| ||.... .|
avqtpeQyrflyefelll
0051429 (Phosphotyrosine protein) phosphatases II 1947-2158 3.4e-55 182.8 In-house 2-224 (272) alignment 
Range on Protein: 1947-2158
Range on HMM: 2-224/272.0
PDSDYINACYIDGYNR---KDCYIAAQGPLPSTVADFWRTiWEYRINHIVMLTGVVEGGKKKCEQYWP---------EKVGENLELPNGFTVTMTSFVQF
| |.|||| ...||.|   .. .....|||| |.|||||  .|..|..||.|....| |. ||..|||         .  ..   | . ..||..|....
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

ADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQfaTSLISFIKRVQKdhnkdkGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESIN--------
 |||.| . ...  | .. ..| |.|.|.||||||||   .|..... ...      | |..||||||..||||...|.... ..  |  ..        
ldyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VYEVLRQLRSKRMYMVQTQAQYVFLHDALDEL
..|....||..|...|||..||.||..|| ||
leeaveelraqrpgavqteeqylflyeallel
0043147 (Phosphotyrosine protein) phosphatases II 1947-2153 1.4e-48 160.2 In-house 3-155 (172) alignment 
Range on Protein: 1947-2153
Range on HMM: 3-155/172.0
PDSDYINACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVveggkkkceqywpekvgenlelpngftvtmtsfvqfadyiirdfkasK
..|||||| |.|.|   | .|| ||||..|.||||| ..|. |.|||.||.                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

AESDEKDLTVSHYHFTSWPDHGVPqFATSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMdrlkqeESINVYEVLRQLRSKRMYMVQTQA
   .    .. .|....|||||||  .  |..|.. ... .....| |  ||||||||||||......|.      ......|.....|.||...||.. 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVFLHD
|| ||..
qyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 1947-2155 8e-39 128.0 In-house 1-149 (151) alignment 
Range on Protein: 1947-2155
Range on HMM: 1-149/151.0
PDSDYINACYIDGYnrkdcYIAAQGPLPstvaDFWRTIWEYRINHIVMLTGVVEGGkkKCEQYWPEKVgenlelpngftvtmtsfvqfadyiirdfkask
| |||||. |..|.     ... .|||.    ||.....|. |..||.|.. .| |  .| .|.||                                  
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

aesdekdLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKdhnkDKGVPLMVHCSAGVGRTGTFIMLDIMMDRlkqeesINVYEVLRQLRSKRMYMVQTQA
       ..| |.....|||.|.|..  ....|.. ...    .|. |. ||||||.|||||...|..|. .      ....|.|...|.||...||.  
.......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYVFLHDAL
|..|.. ||
qflfqlfal
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1948-2151 3.2e-25 83.8 In-house 45-251 (290) alignment 
Range on Protein: 1948-2151
Range on HMM: 45-251/290.0
DSDYINACYIDgYNRKDCYIAAQGPL-------PSTVADFWRTIWEYRINHIVMLTGVVEGGKK----KCEQYWPEKVGENLELpNGFTVTMTSFVQFAD
 .||| | ..  .    . |. | |.        ||. .|| .. . .....|||  . |  ..     |..| ||.|||.| . .|.||  .| ..  |
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf.kgltvkCkskekedd

YIIRDFKASKaeSDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKdhnkdKGVPLMVHCSAGVGRTGTFIMLDIMMDRLK-QEESINVYEVLRQLR
 ..|         ||...|| |. . .| .  |..   .|.| |. |..     .. | .|||  |. |  ..  ... .  .  ...|... .|| .||
vetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvka.....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

SKRMYMVQTQAQYVFL
..|  ..... .. | 
kqralaitsalelafv
0036282 (Phosphotyrosine protein) phosphatases II 1949-2153 5.6e-51 168.0 In-house 2-164 (174) alignment 
Range on Protein: 1949-2153
Range on HMM: 2-164/174.0
SDYINACYIDGYNRKDCYIAAQGPLPstvadFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEkvgenlelpngftvtmtsfvqfadyiirdfkaskaE
|||||| ..|.. . . .|| ||||.     ||. ..|..|...|||.  .| |. || .||||                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

SDEKDLTVSHYHFTSWPDHGVPQFATsLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKqEESINVYEVLRQLRSKRMYMVQTQAQY
..    .. .|... ||||||| ... |..|.|.|.. ...|.| |. ||||||||||||......|. .|. |  .......|.||..|..||||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

VFLHD
 ||..
rflyy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1952-2150 1.8e-34 113.9 In-house 78-272 (301) alignment 
Range on Protein: 1952-2150
Range on HMM: 78-272/301.0
INACYIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQ--FADYIIRDFKASKAES
| | .|.   . . .||.||||..|  |||  .  | ...||||.  ||  ..|||.| | |..|.|.. . |......  .    . . | ..   .  
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi.grfkikiknkelilnkkiskrtlevedstg

DEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkdkgvPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYV
. .  || || ...|.|.|||.  . |  ... |.| ..     |..||||||.||. .||  ...  ... .  |.. | |..|| .|   |||. |  
kfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

F
.
w
0049260 (Phosphotyrosine protein) phosphatases II 1956-2153 2.6e-45 149.1 In-house 1-144 (152) alignment 
Range on Protein: 1956-2153
Range on HMM: 1-144/152.0
YIDGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWpekvgenlelpngftvtmtsfvqfadyiirdfkaskaesdekdlt
.||||...  .||.|||.| |.||||| ..|. |..|||||  .| || |||||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vsHYHFTSWPDHGVPQFATSLISFIKRVQKDhNKDKGVPLMVHCSAGVGRTGTFIMLDIMMdrlkqeESINVYEVLRQLRSKRMYMVQTQAQYVFLHD
  .|... |||||||...  |. ... ..|  ..||| |  ||||||||||||......|.        ....|.....|.||...|... |. ||..
..qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1958-2012 4.9e-12 39.9 In-house 230-281 (440) alignment 
Range on Protein: 1958-2012
Range on HMM: 230-281/440.0
DGYNRKDCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEggkKKCEQYWPE
.|| .|...||.| || ||| |||| . .|||  |.||  . .   | |  ||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1961-2150 2.7e-23 77.4 In-house 32-212 (255) alignment 
Range on Protein: 1961-2150
Range on HMM: 32-212/255.0
NRKDCYIAaqgplpsTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNgFTVTMTSfvQFADYIIRDFKASKAES-DEKDLTVSHY
.||. |.        ||. |..||   . . .|||.   | |..||..|.| .  | | | .  .|| |     || ..|  .     .   |  || ||
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad.vnvtttk..ssadvvlrtleitstlgekkkthtvkhy

HFTSWPDHGVPQFATSLISFIKRVQKDhnKdkgvPLMVHCSAGVGRTGTFIMLDIM----MDRLKQEES--INVYEVLRQLRSKRMYMVQTQAQYVF
... |...  |. |  .   .| |..   |    ...||||.|.||. .|.. ...    .  |.. |   ..  ..|..|||||   ..|  |  |
sykGWieknaPelareilnilkvvrds..k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_hpo-7_pd Subfamily hpo-7 1961-2150 2.1e-19 64.4 In-house 35-218 (263) alignment 
Range on Protein: 1961-2150
Range on HMM: 35-218/263.0
NRKDCYIAaqgpLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNgFTVTMTSFVQfaDYIIRDFKASKA-ESDEKDLTVSHY
.||. |.     |  |.. |..||   . . .|||.   | |..||..|.| .  | . | |  .|. |  ..  | ...  .  .  .   |  || ||
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan.vnvcttkvqs..dvllktlellstlgeKkkthtvkhy

HFTSWPDHGVPQFATSLISFIKrVQKDHnKdkgvPLMVHCSAGVGRTGTFIMLDI----MMDRLKQEESI--NVYEVLRQLRSKRMYMVQTQAQYVF
 .. |...  |. | . .  .| | ..  |    .|.||||.|.||.  | . ..    |.  |.. . .  .  ..|..|||.|   ..|  |  |
sykgWiekndpelareilnilk.varns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1964-2152 1.1e-25 85.0 In-house 5-197 (199) alignment 
Range on Protein: 1964-2152
Range on HMM: 5-197/199.0
DCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFKAS-KAESDEKDLTVSHYHFT
  |||.| ||  |.||||. .||    ||||.       .     |||       .    ..||  . .  .|| |  .  . .. .      .||| ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky.gslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPQFAT--SLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQ--EESINVYEVLRQLRSKRMYMVQTQAQYVFLH
|| ..  |. |    ..   . | | ....|  |..|||| | | || |. ||| .   ..     ....|| ..||  |  .. .  .| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1964-2152 1.2e-25 84.9 In-house 4-196 (198) alignment 
Range on Protein: 1964-2152
Range on HMM: 4-196/198.0
DCYIAAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELpNGFTVTMTSFVQFADYIIRDFKAS-KAESDEKDLTVSHYHFT
  |||.| ||  |.||||. .||    ||||.       .     |||       .    ..||  . .  .|| |  .  . .. .      .||| ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky.gslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPQFAT--SLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQ--EESINVYEVLRQLRSKRMYMVQTQAQYVFLH
|| ..  |. |    ..   . | | ....|  |..|||| | | || |. ||| .   ..     ....|| ..||  |  .. .  .| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1968-2151 3.7e-26 86.3 In-house 95-280 (302) alignment 
Range on Protein: 1968-2151
Range on HMM: 95-280/302.0
AAQGPLPSTVADFWRTIWEYRINHIVMLTGVVEGGKKKCEQYWPEKVGENLELPNgFTVTM----TSFVQFAD------YIIrDFKASKAESdEKDLTVS
    |  ||.  .|  | .|..  .| |...||...||| .|. .|||..|.. . .||.     | . .|.|      | . ..| .| .. ..  ||.
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgr.ytvktvsvktdleeftdkksfklytv.eiknekkkk.kvkktvd

HYHFTSWPDHGVPQFATSLISFIKRVQKdHNKDkgvpLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFL
  .|..||||| |. | . .  .|  .  . |.    ..||||||||||||.. .   ..  ....  .. ...  .|. |   ||.. | ..|
ilafsawpdhGapkeaytaldilkfces.ykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2003-2155 3.1e-07 24.2 In-house 147-298 (332) alignment 
Range on Protein: 2003-2155
Range on HMM: 147-298/332.0
KKKCEQYWPEKVGEnLELPngfTVTMTSFVQFADYIIRDFKASKAESDEKDLTVsHYHFTSWPDH-GVPQFATSLISFIKRVQKDHNKDKGV---PLMVH
 | | ..||||  .  ..|   .... .  ....  .. |. . .|  .   ||   ||  | |   .|..   . . ||      .|  ||   |.|. 
akicrkfwpekrsk.kdfp...alsiqasddhsethmktfnltvtekkqdhqtv.lmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlv

CSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDAL
|..|| .   .  .||.. |. .|  . . | .  .. .|.  ..|   |    . |
catgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystaceml
0048076 (Phosphotyrosine protein) phosphatases II 2008-2158 5.7e-28 92.8 In-house 1-142 (145) alignment 
Range on Protein: 2008-2158
Range on HMM: 1-142/145.0
QYWPEKVGENLELPNGFtvTMTSFVQFADYIIRDFKASKAESDEKDLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDkgVPLMVHCSAGVGRTG
.||| .. ..| | .    |  .. ...|. |.       | .    .. .|....|||||||...  |..|.. ... ....   |  |||||||||||
pywpseilpglylgslp..taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtg

TFIMLDIMMDrlkqeESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDEL
|......|.      ......|.|...||.|...|... |. ||.... ||
tlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 2041-2153 7.3e-27 89.2 In-house 48-139 (144) alignment 
Range on Protein: 2041-2153
Range on HMM: 48-139/144.0
DfkaskaesdekdltVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNkdKGVPLMVHCSAGVGRTGTFIMLDIMMdrlkqEESINVYEVLRQLRSKRMY
               . .|....|||||||.... |..|.. ... ..  .| |  ||||||||||||......|.     .. ....|.|...||.|..
e..............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpg

MVQTQAQYVFLHD
.|... |. ||..
avpnpgqlrfLle
PTEN_1 2046-2115 1.4e-07 26.5 In-house 85-153 (196) alignment 
Range on Protein: 2046-2115
Range on HMM: 85-153/196.0
KAESDEKDLTVSHYHFtSWPDHGVPQFAtSLISFIKRVQKDHNKDK-GVPLMVHCSAGVGRTGTFIMLDIM
  ......  |...|| ...|||.| .. .|. ..|..     .|. |   .||| ||.||.|| ..   |
ydleeffksgveylhf.pieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLm
subfamily_PTEN_pd Subfamily PTEN 2048-2152 1.4e-08 29.9 In-house 74-175 (184) alignment 
Range on Protein: 2048-2152
Range on HMM: 74-175/184.0
ESDEKDLTVSHYHFTswpDHGVPQFATsLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLK--QEESINVYEVLRQLRSkRMYMVQTQ
.|.. |  |..| |.   ||  |..   | .... ..|  ..||    .||| || ||||. |.  ..  .|   .||......  |   . .   .  |
dskkfdgrvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.kgvtiPsq

AQYVFLH
  ||  .
rRYveYy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2053-2195 3.2e-29 96.5 In-house 88-230 (440) alignment 
Range on Protein: 2053-2195
Range on HMM: 88-230/440.0
DLTVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLH
  |. .||. .|||.|||.||  .. .|. |.. ..|    ||.||||||.||||  | .| ..   |. . |... ..  .|..|  ||||  ||.|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALDELTTCGDTSIIGSNLRARVNKMHKMIPGKNITGFQEQYE
.|. |   |||| |.  ..  ||....   |  . . .|...|
eavlegllcgdtliledditerveqiqwpnphtdksplqqefe
PTPc_DSPc_SM00012 2055-2156 1.8e-37 123.1 In-house 1-104 (105) alignment 
Range on Protein: 2055-2156
Range on HMM: 1-104/105.0
TVSHYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDK-GVPLMVHCSAGVGRTGTFIMLDIMMDRLKQE-ESINVYEVLRQLRSKRMYMVQTQAQYVFLH
||.|||.|.|||||||. ..|...... |.| .|| . . |..|||||||||||||..|||....|..| ...........||..|. ||||..||.||.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DALD
.|| 
rall
subfamily_PTPDC1_pd Subfamily PTPDC1 2056-2153 2.6e-08 28.5 In-house 83-170 (182) alignment 
Range on Protein: 2056-2153
Range on HMM: 83-170/182.0
VSHYHFtSWPDHGVPQFAtSLISFIKRVQKDHNKDkgvPLMVHCSAGVGRTGTFIMLDIMM-DRLKQEESInvyevlRQLRSKRMYMVQTQAQYVFLHD
. .| | .|.|.||.    ...  .| |.   ...    . ||| || ||||  |   ..  .||. |..|      . .||||   .||. |  ....
iyvynf.gwkDygvasle.riLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekai......klvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 2058-2152 4.9e-11 38.1 In-house 81-170 (194) alignment 
Range on Protein: 2058-2152
Range on HMM: 81-170/194.0
HYHFTSWPDHGVPQFATSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMM-DRLKQEESINVYEVLRqlrskrMYMVQTQAQYVFLH
.|.   .||.|..     | .|.. |.. .|.|.|    ||| ||.|||||..   ...  ... ||.|. ..  |        ....| ..  |.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleall
subfamily_VSP_pd Subfamily VSP 2065-2152 7.8e-07 23.2 In-house 102-192 (212) alignment 
Range on Protein: 2065-2152
Range on HMM: 102-192/212.0
PDHGVPQFAtSLISFIKRVQKDHNKDKGVPLMVHCSAGVGRTGTFIMLDIMM-DRLK-QEESINVYEVLRQ--LRSKRMYMVQTQAQYVFLH
 || ||..   |..| |.|..  .||.   |..||  | ||||| .   ... . ..  .||.. . . |    .....  ||| .|. ...
ddhnvpkle.ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvg
PTPc_motif_SM00404 2067-2138 5.5e-07 24.6 In-house 60-121 (140) alignment 
Range on Protein: 2067-2138
Range on HMM: 60-121/140.0
HGVPQFATSLISFIKRVqkdhnKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRlkQEESINVYEVLrqlRSKR
  . ..  ....||...     ..||   .||| ||| |..|.|.  .|. |  | .  ..||..   ...|
dklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryr..qlslaeayefv...kerR
DSPc Dual specificity phosphatase, catalytic domain 2070-2138 1.4e-06 23.2 Pfam-A 56-117 (133) alignment 
Range on Protein: 2070-2138
Range on HMM: 56-117/133.0
PQFATSLISFIKRVqkdhnKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRlkQEESINVYEVLRQLRSKR
 ..  ....||...     ..||   .||| ||. |..|.|.  .|. .  . .. . ||.... ||| 
skeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlmktk..nlslneAyefvkerrski
DSPc Dual specificity phosphatase, catalytic domain 2070-2138 1.4e-06 23.2 In-house 56-117 (133) alignment 
Range on Protein: 2070-2138
Range on HMM: 56-117/133.0
PQFATSLISFIKRVqkdhnKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRlkQEESINVYEVLRQLRSKR
 ..  ....||...     ..||   .||| ||. |..|.|.  .|. .  . .. . ||.... ||| 
skeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlmktk..nlslneAyefvkerrski
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2087-2155 4.4e-09 30.1 In-house 260-340 (349) alignment 
Range on Protein: 2087-2155
Range on HMM: 260-340/349.0
HNKDKGVPLMVHCSAGVGRTGTFIMLDIMMD--RLKQEESI--NVY--------EVLRQLRSKRMYMVQTQAQYVFLHDAL
 ..|.  .|.|||||| ||||... ||....     |.||   ..          .. .|| .|. |||  ||......||
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_CG42327_pd Subfamily CG42327 2088-2157 3.4e-13 43.9 In-house 243-313 (319) alignment 
Range on Protein: 2088-2157
Range on HMM: 243-313/319.0
NKDKGVPLMVHCSAGVGRTGTFIMLDIMMDRLKQE-ESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDE
....  ||.|||| ||||||. |  || . .|..  .|... ... ..|  |   |.|. || |..  | |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2096-2158 7.1e-16 52.4 In-house 2-64 (69) alignment 
Range on Protein: 2096-2158
Range on HMM: 2-64/69.0
MVHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDEL
.||||.| ||||||| . . | |.| |  ..... .. .|  |  ||  . .|.|.|||| | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2097-2158 3.1e-15 50.3 In-house 2-63 (69) alignment 
Range on Protein: 2097-2158
Range on HMM: 2-63/69.0
VHCSAGVGRTGTFIMLDIMMDRLKQEESINVYEVLRQLRSKRMYMVQTQAQYVFLHDALDEL
||||.| ||||||| . . | |.| |  ..... .. .|  |  ||  . .|.|.|||| | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
0050432 (Phosphotyrosine protein) phosphatases II 2153-2463 4.2e-84 277.8 In-house 6-306 (308) alignment 
Range on Protein: 2153-2463
Range on HMM: 6-306/308.0
DALDELTTCGDTSIIGSNLRARVNKMHK-MIPGKNITGFQEQYELLDQVGYkpsEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLrpdgSNGSDYINASF
||| ||....||||  |.|. .| ...| . . .......|..| | .|      . || .    |..||||. |.|.   | .|    ..||||||||.
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsy

VDGY--KQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEG-EPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSer
||||  |.....|.|||||..||.|||||..| ..|.|| ....|| |.|||. |||...| ...|||. .||| || . .|||.|.|...| ..|.|  
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges..

egHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQmnsGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFC
  ..||.||.|.||.|| |.|. .......|. . .   ... | | |..||||.|.|...   ||.|..||.||||...|. |..| |    ...|.|.
..rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

HEVLADYVESFDPYA
...|..|....  ..
yralleylklkltkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2163-2463 1.5e-84 278.8 In-house 2-297 (298) alignment 
Range on Protein: 2163-2463
Range on HMM: 2-297/298.0
DTSIIGSNLRARVNKMHKMIPGKNITGFQEQYELLDQVGYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAY
.| |  ..|.| ..|. .. . |..||...... |..|  .  |  .. . .. |  ||||..|..|.  | .|.  |. . ||||||||...||.|||.
nteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnaf

IVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEpvEYGRTKVTLQSEATTPDYTTRKLHICNERggksEREGHVVTQFHFTTW
|.||.||..|| |||||..| .  ||| . |..| .. |.| |||... |  .||. .|.|.|. .  |...|||.. ...    |.. . | |.|||.|
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkk....eekerevrqlhftsW

PEHGHPTSTGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDP
|..| |. . |...|..   . | ..|||...| | .||||||.|  |.| |||.|.|  ||||...|. |..|.|..   ..|||..|.  ....||. 
pdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

YA
..
ei
0051299 (Phosphotyrosine protein) phosphatases II 2164-2456 3.3e-81 268.2 In-house 3-286 (288) alignment 
Range on Protein: 2164-2456
Range on HMM: 3-286/288.0
TSIIGSNLRARVNKMHkmipGKNITGFQEQYELLDQVGYKpseMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS-NGSDYINASFVDGYKQRNAYI
|.|  ..|. .|.|..     ...||..|..| | .. ..   . .| .    |..||||. |.|..  | .|.. .. .||||||||..|||.. ...|
teisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

VTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTkeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREGHVVTQFHFTTWP
.|||||..||.|||||..| ..|.|| ....|| |.|||. |||.  |....||. .||| || . .|||.|.|.. | .  . . | . ||.||.|.||
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

EHGHPTSTGSIIELIDLLTRAQMnSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
.|| |.|. ...... |. .|.  ||.. . | |..||||.|.|...   ||.|..||.|||....|. |..| |.   ...|.|..|.|..|.
dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 2164-2460 3.8e-64 211.6 In-house 2-301 (306) alignment 
Range on Protein: 2164-2460
Range on HMM: 2-301/306.0
TSIIGSNLRARVNKMHKMIPGKNITGFQEQYELLDQVGyKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNGSDYINASFVDGY--KQRNAY
||.. .... ||....|    .. .||.|..| |.|   . . .  ..|. . |  ||||  |.| .  |  |. ..  |||||||.....   .....|
tsllakeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksy

IVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVeYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREghvVTQFHFTTW
| ||| |.||| |||||... ..| ||   . || |.|||  |||..| ..  ||. .||  || .. ||. |.|...... .|.|||   | |.||..|
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeere...vfqyhfksW

PEHGHPTSTGSIIELIDLLTRAQMNSG---NKAITVVCNDGVGRSGAFLCIHSQLERLKT---EGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADY
|.|| |...| ...... ..| | ..    . .| | |..|.|| |.|. |   |. ...   . ..|. |  |..|. | ||.   . | | ..... |
PdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

VESFD
.|.  
ietkk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2170-2467 9.6e-81 266.3 In-house 6-291 (318) alignment 
Range on Protein: 2170-2467
Range on HMM: 6-291/318.0
NLRARVNKMHKmipgKNITGFQEQYELLDQVGYKPSEMmYSdgTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPL
.|. .|.....    .  . ..|.|| |...  .....  |  .. ||  ||||  |.. .  | .|.. .|..|||||||...|||....||| .|.||
dleshvrrlre....sGelllseeyerlsrseetvtsl.ks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPl

KTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEgePVEYGRTKVTLQSEATTPDYTTRKLHICNerggKSEREGHVVTQFHFTTWPEHGHPT
  |..|||||. | ....|| . ...|.|..|.| ||| |.  . .||. .|.|..| .. ||. |.... .    . | |  .| |.|.|.||..| |.
petieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpe

STGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYANFKD
|..|...|.   ..||..||...|.| |  |||| | |. . ..|||.| |. ||||.. |. |..|  .    | |.|...|| ....|.|.... .|
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasd
subfamily_PTPN9_pd Subfamily PTPN9 2175-2456 6.1e-59 194.5 In-house 3-290 (297) alignment 
Range on Protein: 2175-2456
Range on HMM: 3-290/297.0
VNKMHKMIPGKNITGFQEQYELLDQvgyKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVD
.... ...  |.. | ...|. . .   .| |  .    . .|. |||| ... ..  |  |   |. . ||||||.|||||||..|.| |||||| ||.
ieelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERggksEREGHVVTQFHFTTWPEHGHPTSTGSI
|||||. | ....||    .||.|. ||  |||..|..  |.|  .|.  .  .. ||..|.|.| | .    ..|   || | |..||..| | |. |.
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk....teesrkvthfqflsWPdyGvPssaasl

IELIDLLTRAQMNS------------GNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
.....   ..|  .             .  | | |  |.||.|.|  .   |.||...| |||.. .|. ||.|   .   . |.||.  . .| 
ldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2176-2465 3.5e-70 231.2 In-house 8-287 (287) alignment 
Range on Protein: 2176-2465
Range on HMM: 8-287/287.0
NKMHKMIPGKNITGFQEQYELLDQVGYKPSEMMYsdGTTTVNVPKNRYPEIVPLNMHRPRLRpdgSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDF
... .  . |. .||..|. .|.||. .. |.    . .. | .|||. .|.. . .|  |.    .  |||||.|.||||...|.|....|.  |. .|
gefvakghakgnegfknqftvleqvtqredevth..niasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnf

WRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGepVEYGRTKVTLQSEATTPDYTTRKLHICNERggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIE
|..| . .  .||  |.  |. .|.|. |||...   | .|  ...| .| .. .|. |||.. |.    .. . . |.|...|.|...|. |.  .|. 
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknkn...kagdkqqvkqyqitnWdstgkvtepqtill

LIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYANF
.|.   ..|  .|| .| | | |.||||. |. .   ... |||| .|||. ||  | .. | .   ..| |  ...  |..||. |..|
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0039614 (Phosphotyrosine protein) phosphatases II 2178-2459 7.2e-74 244.2 In-house 22-292 (297) alignment 
Range on Protein: 2178-2459
Range on HMM: 22-292/297.0
MHKMIPGKNITGFQEQYELLDQVGYkpSemmYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS--NGSDYINASFVDGYKQ-RNAYIVTQGPLKTTVDD
...... ...|......| | ..    .   || .   .|..||||..|.|.. .| .| | ..  ..|||||||.||||..  ...|.|||||. ||.|
llllekansktllllefeellslkp..d...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWRMIMEFKTRTIVQFCNTVEEGQeKCHMYWPTKEGepvEYGRTKVTLQSEATTPDYTTRKLHICNerGGKSeregHVVTQFHFTTWPEHGHPTSTGSII
||||. | ....||  ...|| |. ||. |||...|   .||. .||| .. . ..||.|.|.. |  .|.|    . ||.|..| ||.|| | |. ...
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..nges....rtvthfqytgwpdhgvppslelll

ELIDLLTRAQMNS-GNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESF
|...|. .|. .. ... . | |..||||.|.|...   ||.|..||.|||.. .|. | .| |    ...|.|....|....  .
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0036941 (Phosphotyrosine protein) phosphatases II 2180-2463 5.6e-78 257.5 In-house 5-284 (297) alignment 
Range on Protein: 2180-2463
Range on HMM: 5-284/297.0
KMIPGKNITGFQEQYELLDQVGYKPSemmYSDGTTTVNVPKNRYPEIVPLNMHRPRLrpdGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMI
.... ..........| |... . .|   .| .    |..||||. |.|..  | .|   ...||||||||.||||.. ...|.|||||..||.|||||.
llekllflalllkefeellpllllgs...lsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv

MEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEAT--TPDYTTRKLHICNERGGkserEGHVVTQFHFTTWPEHGHPTSTGSIIELI
.| ....|| ... || | |||. |||..|||...||. .|||.|. .   .|||.|.|.. . ..|    | ..||.||.|.||.|| |.|. |....|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng....esrtvthfhytgwpdhgvpespaslldfi

DLLTRAQMNS-GNKAITVVCNDGVGRSGAFLCIHSQLERLK---TEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYA
.|. ... .. ... . | |..||||||.|...   |..|.   .||.||.....|. |..| |    |..|.|..|.|.... ..... 
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0045450 (Phosphotyrosine protein) phosphatases II 2180-2456 2.5e-74 246.1 In-house 19-304 (307) alignment 
Range on Protein: 2180-2456
Range on HMM: 19-304/307.0
KMIPGKNITGFQEQYELLDQVGYKPsEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS--NGSDYINASFV--------DGYKQRNAYIVTQGPLK
.. . ...||.....| | .|  ..  . || .   .| .||||..|.|.. .| .| . ..  ..|||||||.|        |||.. ...|.|||||.
llllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

TTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNErggKSEREGHVVTQFHFTTWPEHGHPTS
 ||.|||||. | ....||  ...|| |.|||..|||.. ||...||. .||| || . ..|| |.|.. .    . . |.. ||.||.|.||.|| |.|
etvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgwpdhgvpps

TGSIIELIDLLTRAQMNS-GNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGE---VDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
. .....|... .|. .. ... . | |..||||.|.|...   |..|..||.   ||... .|. | .| |    ...|.|..|.|....
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 2182-2456 2e-72 239.3 In-house 14-277 (278) alignment 
Range on Protein: 2182-2456
Range on HMM: 14-277/278.0
IPGKNITGFQEQYELLDQVGYkpseMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIM
.  .. |......| |... .    ..|| .    |..||||. |.|.. .| .| . .| ..|||||||.||||.. ...|.|||||. ||.|||||. 
lllnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

EFKTRTIVQFCNTVEEGQEKCHMYWPtkeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSeregHVVTQFHFTTWPEHGHPTSTGSIIELIDLL
| ...|||  .. || |..||. |||   |....||. .|||..| . .|||.|.|.. | . |.|    . ||..|.. ||.|| |.|. ......  .
elgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges....rtvthyhylgwpdhgvpeslsllldflkav

TRAQMnSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 .|.  . |... | |..||||.|.|...   ||.|..||.||... .|. |..| | .  ...|.|..|.|..|.
reale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2183-2456 3e-73 241.4 In-house 16-279 (288) alignment 
Range on Protein: 2183-2456
Range on HMM: 16-279/288.0
PGKNITGFQEQYELLDQVGYKPSEMMysdGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIME
  .| |||.|.|. | ... . |. .   |  .|| .||||..|.|....| .|.  .  .|.||||||..||.|....|| |||||  ||.|||... |
sarnrtgfseeynsLaalektksvta...grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

FKTRTIVQFCNTVEEGQEKCHMYWPTKEgEPVEYGRTKVTLQSEATTPDYTTRKLHICnerggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLT
 || ||| . . ||.|..||. |||... .|..||  .|||... .. |...||| .        . .   .||.....||.|| | |.  ..||.. . 
nktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskapllellrqvk

RAQMNSgNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 |. .   . |.|.| .||||.| |. ..  ......|  .||.  ..  | .|  |  .| .|.|..|||.. .
vanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0047943 (Phosphotyrosine protein) phosphatases II 2184-2456 6.7e-77 253.9 In-house 8-272 (273) alignment 
Range on Protein: 2184-2456
Range on HMM: 8-272/273.0
GKNITGFQEQYELLDQVGYkpsEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLrpdGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFK
 ...|...|..||| ..     .. || .    |  ||||. |.|..  | .|   |..||||||||.||||.. ...|.|||||. ||.|||||..| .
llgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

TRTIVQFCNTVEEGQEKCHMYWPTKEGE-PVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSeregHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTR
.|.||  ...|| |.|||. |||...|| ...||. .||| || | .|||.|.| . |   |.|    ..||.||.|.||.|| |.|. |..|.|.|. .
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtges....rtvthfhytgwpdhgvppslesllefielvrk

AQMNS-GNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
|. .. .|. . | |..||||.|.|....  |..|..||.|||....|  |..| |    ...|.|..|.|..|.
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 2184-2461 1.8e-76 252.8 In-house 14-281 (317) alignment 
Range on Protein: 2184-2461
Range on HMM: 14-281/317.0
GKNITGFQEQYELLDQVgyKPSemMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS-NGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEF
 .. |...|..| |...  |..   || .   .| .||||| |.|.   | .| |.|. ..|||||||.|||.......|.|||||. ||.|||||..| 
ksdftalleefedllsl..kld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

KTRTIVQFCNTVEEGQEKCHMYWPTkeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNErggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTR
....|| .....| |.|||. |||.  ||...||. .|||.|| . ...| |.|.. .      . | . ||.||.|.||.|| | |. ......... .
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl....gdsesrtvthfhytgWpdhgvppspdllldfleavre

AQMnSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDP
|.  .... . | |..||||.|.|...   ||.|..||.|||.. .|. | .| |    ...|.|....|..|.  ...
ale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_PTPRB_pd Subfamily PTPRB 2184-2457 5.6e-71 234.0 In-house 21-286 (293) alignment 
Range on Protein: 2184-2457
Range on HMM: 21-286/293.0
GKNITGFQEQYELLDQVGYKPSEMMysdGTTTVNVPKNRYPEIVPLNMHRPRL-RPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEF
 .. ..|.|.|| | .|| . . ..    ...||  |||| .|.| .. | .|   ....|||||||....||.... .|.||||| .||||||||..| 
adsdlrfseeyeelkavgkdqavka...aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwek

KTRTIVQFCNTVEEGQEKCHMYWPTKEgEPVEYGRTKVTLQSEATTPDYTTRKLHICNerggksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTR
|...|| . ..||.|..||. |||..| ||| ||  ||||..| .. |...|.|.|..      |.| . |.|.|||.||.|| | .| ......  . .
kssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek......ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

AQ-MNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
|.  .. .. |.| |  ||||.|.|....  |.....|  ||.|  .   |..|  |.   ..|.| |... |...
aiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 2185-2458 1.2e-69 230.0 In-house 16-289 (563) alignment 
Range on Protein: 2185-2458
Range on HMM: 16-289/563.0
KNITGFQEQYELLdQVGYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPD-GSNGS-DYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEF
.. .||.|..| | |   ..... ..    . |  |||| .||. .  | .|.|  | ... |||||...|||.. .|.|.||||||.|.||||||| | 
dgdigfseefeal.qsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

KTRTIVQFCNTVEEGQEKCHMYWPTkeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSER--EGHVVTQFHFTTWPEHGHPTSTGSIIELIDLL
.. .||   | ||.|..||..|||.   |...||  .|||..| ..  ||.|.| | | .  | ..  . ..|.|.|.|.||.|| |...   .  .   
nvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

TRAQMNSgNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVES
 .|...     |.| |. ||||.| .. . . |.....|  |.||. ||. |..|  |. . . |.| |..| . . |
saankae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2185-2462 1.7e-68 225.6 In-house 17-289 (290) alignment 
Range on Protein: 2185-2462
Range on HMM: 17-289/290.0
KNITGFQEQYELLDQvGYkpSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNG---SDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIME
|. .||..|.. ||. |   ||     |.|. | ..||. .||. . .|  ||| ...     .||||....|||....||.||||.. |. |||..|..
kgnegfrnqfkmlds.ge..sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

FKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPveYGRTKVTLQSEATTPDYTTRKLHICNERGGkseREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLT
 |.  ||  .| .|||..||. |||... .   ||  ...|..| |. .|..|||.. |.. .    . . |||...|.|...|. | . .|. .|   .
ekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsa...gakqsvtqyqitnwdstgkvtnpqtillvieemy

RAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPY
. |  .||..| | | |.||||. |. ..  ... |||| .|||. ||. |. . |..   ..| . ....  |..||. |
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2185-2457 1.3e-57 190.1 In-house 12-277 (281) alignment 
Range on Protein: 2185-2457
Range on HMM: 12-277/281.0
KNITGFQEQYELLDQVGYKPSEMmysDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSN-GSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFK
.. .||.|.|| | ..| . .       ..  || ||||  ||  .  | .. |. .|  .|||||.||.|||. ..||.||||. .....||.|..| |
ndnaGfieeyeklaaigvdntat...askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

TRTIVQFCNTVEEGQEKCHMYWPtKEGEPVEYGRTKVTLQSEATTPDYTTRKLHIcNERGGKSeREghvVTQFHFTTWPEHGHPTSTGSIIELIDLLTRA
 ..||   . .|.|. ||| |||  . . ..||  .|. ..|.... | .||... ....|.. ||   |.|...|.||.|| |..|  ..|  . ....
vsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresget.re...veqlaytaWPdhGvPattkellefrkevlkl

QMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTE-GEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
. .. . .. . |  ||||.|... .   ......|  |.||   ..  | .|  ..  .  | | . .. |...
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2185-2463 2.6e-54 179.0 In-house 12-300 (301) alignment 
Range on Protein: 2185-2463
Range on HMM: 12-300/301.0
KNITGFQEQYELLDQVGYKPSEMMYSDGtttvNVPKNRYPEIVPLNMHRPRLRPDGS---NGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIME
|. ..|.|||. |...  |.... .|.     | . ||. .|.... .|  |.|  .      .|||||..|||......|..|||.| |. ||||.|..
khsnkfeeqykelkegedksctvglsee....nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

FKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGG-----------KSEREGHVVTQFHFTTWPEHGHPTST
 |. .||  .|. |. ..||. |||. | |  |.|  .|||..|.. ||.. |.| .  . |            ||..... |.|.. | ||..|     
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

GSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYA
  ... ||    .|   |   . | | |.|.||| .  .   ||  | || ||||.  |. |  . |    |. |.. ..|.  |..  . ||
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya
subfamily_ptpA1_pd Subfamily ptpA1 2185-2409 8e-30 98.9 In-house 18-249 (418) alignment 
Range on Protein: 2185-2409
Range on HMM: 18-249/418.0
KNITGFQEQYELLDQVgYKPSEMmySDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRnAYIVTQGPLKTTVDDFWRMIMEFK
| |   .|.. ||..    |||   |.|    |  |||| .|.|.|  | .|.  .  .||||||| ..||   .  .|.|||||  |. |||||. | .
kcihkikeefrllees.vgpset..segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenr

TRTIVQFCNTVEEGQEKCHMYWPTKEG-EPV-EYGRTKVTL---QSEATTP-DYTTRKLHICNERgGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELI
 | || .    |. . ||  ||| . | | .  ||  .  .     |     .   |..   | |    | | . .||...  ||.|  |  |  . .|.
criivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnir.ltfegetrditqyqyegwpdhnipdhtqpfrqll

DLLTRAQMN---S--GNKAITVVCNDGVGRSGAFLCI
  .|  | .   |   |  | | |. ||||.|.|   
hsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_PTPN23_pd Subfamily PTPN23 2186-2457 2.9e-50 165.7 In-house 13-281 (288) alignment 
Range on Protein: 2186-2457
Range on HMM: 13-281/288.0
NITGFQEQYELLDQVGYKPsEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRpdgSNGSDYINASFVDGYKQR-NAYIVTQGPLKTTVDDFWRMIMEFKT
. |........|.|   |      |     ... |||. .|.| .  |  ||   ..  |||||||| .       .|.||.||..|. |||.|..| |.
gktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

RTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREGHVvtqfHFTTWPEHGHPTSTGSIIELIDLLTR--
..||   .  | |..|.. |||...||.|..|  .|||.|. .|. .  |.|..  ..  . .   |.    ..|.|||.| | | .......|      
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshl....qltsWpelGvPasPetllqfldevesay

-AQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLK-TEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
 |. .  .. . | |  ||||.|.| .. . .. |.  .| .|. . ... |. |   ..| ... |. |.   ...
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2187-2460 2.2e-109 360.3 In-house 21-287 (305) alignment 
Range on Protein: 2187-2460
Range on HMM: 21-287/305.0
ITGFQEQYELLDQVgYKPSEMmysdGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNG-SDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTR
 .|...||..| .   .. ..    |....|. |||. ||..|...| .|... |.. |||||||.|||||....|||.|||||.||.||||.|.|.|..
dkgleaqykslyee.eesidv....gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

TIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGgksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQM
|||.....||.|..||..|||....|..|.|...|.|.||.|..||..|||.|..|..   ..|...|.|...|.||.||.|....|...||. ....|.
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqk

NSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFD
.. .....|.|..||||.|.|.... .|||||.|..||||..||..|..|......||.|||.|..|.......|
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Ptp69D_pd Subfamily Ptp69D 2187-2459 3e-65 215.4 In-house 21-289 (307) alignment 
Range on Protein: 2187-2459
Range on HMM: 21-289/307.0
ITGFQEQYELLDQVgykPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTR
  |... || | .     ..   . .    |  ||||..|.. . .| .|..  |.. ||||||||. |||... .|. |.|. .|..||||||.| .  
dfglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVQFCNTVEEGQEKCHMYWPTKegEPVEYGRTKVTLQSEATTPDYTTRKLHICNER-GGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQ
.||   |  |  ..||. |||    . |.||   |.| || ...||. |.|.. .    .  . . . |.|.|.|.|..   | .. ....||. .   .
livmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

MNSgNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESF
 .. .  |.| |. |||||| |... | |..||.| .||.|.  |  | .|  |.  |. |||..  |.|| .  
kln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2187-2452 8.9e-48 157.6 In-house 5-262 (283) alignment 
Range on Protein: 2187-2452
Range on HMM: 5-262/283.0
ITGFQEQYELLDQVGYKPSEMMYSdgTTTVNVPKNRYPEIVPLNMHRPRLRPDGSngsDYINASFVD---GYKQRNAYIVTQGPLKTTVDDFWRMIMEFK
 .... ..| |....  . .   .  ..  | .|||. |||| ...| .|...     |||||.|.     ||| . ||..|.||. || |||.|. . |
vnnnklfrevlkrlsvpdldadia..sadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

TRTIVQFCNTVEEGQEKCHMYWPTKeGEpVEYGRTKVTLQSEATTPDYTTRKLHICNErggKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELiDLLTRA
  .|| . .  |. ..||  ||| . |  ..||   |||. | |   .. ..| . ..    | ..  ... . .  | | |  .   |.. . ...   
itaivmltklqedlrikCsqyWPkr.Gs.edyGeftvtlrkettsnsfiikelllrvn...ssakstlllahyqvidWleygeqaiinslvkf.nkvisl

QMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVL
| .| .  | | |  |.||...|. . . .. ..||  ||||. .|  | .|.... .|| | . ||. 
qteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2187-2436 5.7e-27 89.1 In-house 26-271 (310) alignment 
Range on Protein: 2187-2436
Range on HMM: 26-271/310.0
ITGFQEQYELLDQVgyKPSEMMYSdgTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRT
| |.  ||  ||    . | . |   . . .. |||| ..| |.  | .|. | |   ||| | .|     |...|..||||. |. ||||||.. .. .
ieglvkqyrkldak..qdssltye..aykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraes

IVQFCNTVEEGQEKCHMYWPTKeGEPVEYGRTKVTLQSEATTpDYTTRKLHIC--NERG----GKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELiDLL
|. .|...|||. ||  |||.  |    ||  .||  ||..  ..   .| .    .        .. ..  |.  ..  ||. | |      .    ||
illlckvgeegrpkcvgywpsl.gvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rll

trAQMNSGNkaITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDvFKYLKTARTRR--I
  ||.  |     | |  |..| .. . .. ....|.   .|| ....||   ..  |
..aqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvd.aeevktellksrai
subfamily_PTPRK_pd Subfamily PTPRK 2188-2453 2.2e-61 202.4 In-house 22-274 (314) alignment 
Range on Protein: 2188-2453
Range on HMM: 22-274/314.0
TGFQEQYELLDQVgykpsemmYSDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRT
 ||.|.|| | .         .       |  |||. .|.. . .|..| . || . ||||||...|.||. .|.|||||||. || ||||.. . .. .
ygfkeeyeslfeg........wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencas

IVQFCNTVEEGQEKCHMYWPTKEGEpveYGRTKVTLQSEATTPDYTTRKLHICNERggKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMN
||   . ||.|. ||  ||| .      ||  ||.| .  .  .. .| . ...    ..  | ..| ||.|..||.|. |.|  ....|.  .   | .
ivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrvekla..rgqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee

sGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLA
 ..  | | |  | ||.|.|. |.. |. ...|| ||||.  || |.|.. ..   . |.|...|. 
.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvil
0046845 (Phosphotyrosine protein) phosphatases II 2189-2464 4.1e-79 261.2 In-house 1-282 (284) alignment 
Range on Protein: 2189-2464
Range on HMM: 1-282/284.0
GFQEQYELLDQVGYKPSeMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS--NGSDYINASFVDGY-----KQRNAYIVTQGPLKTTVDDFWRMIME
|..|..| | .. .|.. . .| .    |. ||||. |.|..  | .|.. ..  ..|||||||.||||     ......|.|||||..||.|||||..|
gleeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

FKTRTIVQFCNTVEEGQEKCHMYWPTKeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNErggKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLT
 ..|.|| ....|| |.|||. |||.. ||...||. .||| || . .|||.|.| . |.   . . | . ||.||.|.||.|| |.|. ...|...|. 
qnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl...gytgesrtvthfhytswpdhgvppspedlleflrlvr

RAQMN-SGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEG---EVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYAN
... | .|.. | | | .||||.|.|....  ||.|..||   .|||....|  |..| |    |..|.|..|.|..|. ..  ...
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2189-2454 8.9e-60 197.6 In-house 35-289 (319) alignment 
Range on Protein: 2189-2454
Range on HMM: 35-289/319.0
GFQEQYELLDQVGYKPSEMMYSDgtTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTI
 .. ..  . ..| . ... ...     |  |||. .|.. .  . .|.. .| ..|||||||||.||.... || .||||. |..|||||| |... ||
klevefrracklgvnladqtfan..ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VQFCntveegQEKCHMYWPTKEGEpvEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREghvVTQFHFTTWPEHGHPTSTGSIIELIDLLT-RAQMN
| .       ..||  ||| |  .  ...| || ..|   | .|. |.... ..   |  |.   .|||||  ||..| | ..  .. |.. ..   . .
vllt......kdkcsqywplkivi..keerfkvkvdsveetaeyvvrdielsedgkekdirk...itqfhflGwpdvGvpdypsdlmrlvkkvrhltske

SGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLAD
 ... | | |  ||||.|... ..  |.|.| |  |||.....  | .|  |. .|  | |..  | .
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2189-2454 4.2e-59 195.0 In-house 25-277 (315) alignment 
Range on Protein: 2189-2454
Range on HMM: 25-277/315.0
GFQEQYELLDQVGYKPSEMmysdGTTTVNVPKNRYPEIVPLNMHRPRL-RPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTI
||...|| .     .| ..       . |. |||| .|.. .  |..|   .  ..|||.||.|.|||.... || .|||. ..|.||||...| .  .|
gfkqdyesipggqlhpldv....akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigki

VQFCNTVEEGQEKCHMYWPTKegePVEYGRTKVTLQSEATTPDYTTRKLhicnerGGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNS
| . |.||. ..|.  ||| |    | ||.  ||..||    .|| | |         .. . . | |.|.|.||. | | .| ....||    . . ||
vmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl......svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtns

GnKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLAD
   || | |..||||.|.|... . |.....|  .||.....  |  ||.... .. | | ...| .
v.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2189-2457 1.4e-49 163.5 In-house 7-260 (267) alignment 
Range on Protein: 2189-2457
Range on HMM: 7-260/267.0
GFQEQYELLDQVGYKPSEMMYSdgTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNgsdYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIV
 .....||....  . | .  |   .. |  .||. . .| .  |  ||    .   |||||.|.|||..||.||||.||| |. ||. .|.. |  .||
eiekefelikkisdtsstisqs..iaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

QFCNTveeGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHIcnerGGKSErEGHVVTQFHFTTWPEHGHptSTGSIIELIDLLTRAQMNSG
   ..   .... ...|| | |.  .|    |    |    ||    | .      | |   | || ...  |           .  |. .|.. |.. |
lltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel....kfkne.sahnvtlyyykkwnintn..nkpylkplfgilaknqleng

NKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
|. . | |.|||||||.|| |.|||||.|||| .|.|..|. .| .||||.  ...|...||.||.| |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2190-2461 3.1e-76 251.5 In-house 25-288 (319) alignment 
Range on Protein: 2190-2461
Range on HMM: 25-288/319.0
FQEQYELLDQVGYKpsemMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIV
......||.. . .     ..  ..  | .||||..|.. .  |  | . ||..|||||||||.|||..|...| ||.||..|..|||||. | .. ..|
lekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

QFCNTVEEGQEKCHMYWPTKegEPVEYGRTKVTLQSEATTPDYTTRKLHIcNERggKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSG
  .. ||... |.. |||..  ...||||  |||..|  . ||  |||.. |..  .|| |   |..|..| ||.|. |... |...|.  . ... .. 
mltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklkl.nkk..ssevetRevkhfqyteWpdhdvPekatslldllkrirksrektq

NKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDP
.. |.| | .|||| |.|. ..  |||.| || .|||.. .. || |  . .. . | |..|.| ..||..| 
sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
DSPc_SM00195 2190-2456 8.7e-74 243.5 In-house 2-262 (263) alignment 
Range on Protein: 2190-2456
Range on HMM: 2-262/263.0
FQEQYELLDQVGYKPsemMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDG-SNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIV
..|..| |..   .      ...    |. |||| .|.| .  | .| ..  ..|||||||....|......||.|||||..||.|||||..| |...||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

QFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTP-DYTTRKLHICNERGgkseREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNS
 ... .|.|.|||. ||| ..|.. ..|. .|.|... ... ....|.|.. .|      .| . |||.....||.|| | || |..||.  ..  . .|
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts

gNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 .. | |.| .||||.|.|..|.. |..|..| .||.|. .|  |. |.|. ..|..| |..|....|.
.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2190-2456 8.7e-74 243.5 In-house 2-262 (263) alignment 
Range on Protein: 2190-2456
Range on HMM: 2-262/263.0
FQEQYELLDQVGYKPsemMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDG-SNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIV
..|..| |..   .      ...    |. |||| .|.| .  | .| ..  ..|||||||....|......||.|||||..||.|||||..| |...||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

QFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTP-DYTTRKLHICNERGgkseREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNS
 ... .|.|.|||. ||| ..|.. ..|. .|.|... ... ....|.|.. .|      .| . |||.....||.|| | || |..||.  ..  . .|
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts

gNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 .. | |.| .||||.|.|..|.. |..|..| .||.|. .|  |. |.|. ..|..| |..|....|.
.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2193-2300 1.9e-11 38.1 In-house 10-117 (332) alignment 
Range on Protein: 2193-2300
Range on HMM: 10-117/332.0
QYELLDQVgyKPSEMMYSDGTT--TVNVPKNRYPEIVPLNMHRPRLRPDGSNgSDYINASFVDGYKQRNAYIVTQGPLKTTV-DDFWRMIMEFKTRTIVQ
  |||.|.  . | | | .       |.  || | .  ..  |  | |.  .  |. |||.|||| ...|||..| |..      ||||. | |   |. 
gpellnqm..htsamtypntydkflnnmdmnriphlycfdhsrvelapqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilv

FCNTVEEGQEK
| .  |. . |
fgdidekqkrk
subfamily_PTPN3_pd Subfamily PTPN3 2198-2457 2e-51 169.6 In-house 22-277 (280) alignment 
Range on Protein: 2198-2457
Range on HMM: 22-277/280.0
DQVGYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRpdGSNGsDYINASFVD----GYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNT
.|.  |  ..  |    . |..|||| .|.| .. | .|.   |.  |||||..|.    . .. | ||.|||||..|. |||.|. | |...|| . ..
eqlyrkkpglaisaarkpenlsknryrdilpydatrvklk..eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VEEGQEKCHMYWPTkEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERggksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQmNSGNKAIT
||.|. ||| |||. ... .|||. .|....|..|  | .|.| .....    ..| . ..|. .. ||.|| |... ...|... . ... .. .. . 
verGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdke....tkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvv

VVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVF-CHEVLADYVE
| |  |.||.| .. .   |  . .. .| . . ..| | .|  |.   . | | |. .|. | |
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_PTPN14_pd Subfamily PTPN14 2198-2457 1e-45 151.0 In-house 30-297 (300) alignment 
Range on Protein: 2198-2457
Range on HMM: 30-297/300.0
DQVGYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNGSDYINASFVDGY--KQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVE
...  |  . ..| ..  .|..|||.....| .  | .| |   | ..||||| .      ..  |||.||||..|| |||.|. | ... ||.  .. |
eripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeee

EGQEKCHMYWPTK--EGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERgGKSEREghvVTQFHFTTWPEHGHPTSTGSIIELIDLLT--RAQMNSGN--
.|.||.. |.| .  . . ||.|. ||| .   ... ..|..|..      | ||.   |  . .| ||.|| |    . .. .. .   | ..|| .  
dgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeert...vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

----KAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
      . | | .||||.|  .     .. |... |.|. | |.. |..|  |.. |  | | ..||  |..
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN1_pd Subfamily PTPN1 2199-2448 2e-46 153.1 In-house 14-263 (290) alignment 
Range on Protein: 2199-2448
Range on HMM: 14-263/290.0
QVGYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSngsDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQ
..  . |..  ..  .  | ..||| .. | .  | .|. .     ||||||.|.  . .  ||.|||||  ||| ||.|. | |....| . . ||..|
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

EKCHMYWPTKEG-EPVEYG--RTKVTLQSEATTPDYTTRKLHICNerggKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNKAIT-V
 ||. |||..|  . ...   . ||.| || ..  || |.|.. |    .. .| .....||.||||. | | | .. ....  . .. . | ..  . .
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelen....lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavi

VCNDGVGRSGAFLCIHSQLERLKTEGE---VDVFKYLKTARTRRIGLLSELDHYVFC
 |  |.||||.|  . . | ... ...   ||. | |  .|  |.||.   |   | 
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2201-2459 3.5e-39 129.2 In-house 39-286 (290) alignment 
Range on Protein: 2201-2459
Range on HMM: 39-286/290.0
GYKPSEMMYSDGT-TTVNVPKNRYPEIVPLNMHRPRLRpDGSNGsDYINASFVDGYKqrNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQE
 | |....  .   .  .. |||| ..|  .. |  |. || .| ||. | .|.| |    .|.|||.|| || |.|||... |. .|| .|. .|.|. 
pylpvqylerkifdkntefkknrykdvvcndktrvilk.dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCHMYWPTKEGEPVEYGRTKVTLqSEATTPDYTT--RKLHICNERGGKSeregHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAqmnSGnkAITVVCN
||. |.| |||| . .|   |.  || ...|  .  . | . .   ||.    |..  ..  .||..  . || ... ..  | .|   ||   ..| | 
kceqyypekeGevltfGeitvlc.seeddkdaniikktlsvrdkdsGke....hklkhlkikswpdksvalstlallrtlrilrka...sG..pvvvhcs

DGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESF
 |.||.|.|  |   |. |    |.|. .  .. |  |.. .     |.   |.| |.  .|
aGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_PTPRN_pd Subfamily PTPRN 2201-2457 7.2e-39 128.2 In-house 40-293 (297) alignment 
Range on Protein: 2201-2457
Range on HMM: 40-293/297.0
GYKPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS-NGSDYINASFVDGYKQR-NAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQ
 |.  .   . . .  || |||. ...| .  | .|. . | . |||||||..     |  ||| ||||| .|| |||.|. |  .  ||....  ||| 
ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv

EKCHMYWPTkEGEPVeYGRTKVTLQSEAT-TPDYTTRKLHICNERggksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNsGNKAITVVCN
..|. |||  ||. | |.  .| | ||   . ||  | ... | .     .|   |||||| .|||.| |.|. |..|.   . ..       .| | | 
kqckrywpd.eGsev.yhiyevhlvsehiwcddylvrsfylknlq....tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcs

DGVGRSGAFLCIHSQLERL-KTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
||.||.|... |   |.|| |   |.|.   |.  | .| ||.   | . |.  ..|. |.
dGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2201-2456 4.4e-28 93.1 In-house 21-270 (285) alignment 
Range on Protein: 2201-2456
Range on HMM: 21-270/285.0
GYKPSEMMYSdgTTTVNVPKNRYPEIVPLNMHRPRLRpdgSNGSDYINASFVD-GYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQE
|| | .  |.  .   |   ||| ..  ..  |  |.       ||| ||..    |....|| |||||  |. |||.|| . |   .. .|  .| | |
gymppnctyt..ayeanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggve

KCHMYWPTKEGEPVEYGRTKVTLQS--EATTPDYTTRKLHICNERGGKSEreGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTraQMNSGNKAITVVCN
|| .|.| | || |..|. ..||    | .        | . |     ||     . . .   ||..  |  .  .|||   .   ..|  .| | | |.
kcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasse..plymnhvqvpwwpdqlapedarpmielykwvk..kvnpkekpicvhcs

DGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 ||||. .|. |     |.  . .....  ..  |. |.  .    ...| . || .|.
agvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2201-2456 3.2e-27 89.9 In-house 22-269 (281) alignment 
Range on Protein: 2201-2456
Range on HMM: 22-269/281.0
GYKPSEMMYSdGTTTVNVPKNRYPEIVPLNMHRPRLRP--DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQ
|  ||..        ||  |||| .|  |.. | .|.      | .||| | ..     .  ||.|||| | |  |||||| . .| .|| .|. .|  .
gdppsdlctv.fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr

EKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNErggkseREGHVVTQFHFTTWPEHGHPTSTGSIIELidlLTRAQMNSGNKaiTVVCND
|||  |.| .    ... .  |. .  .      | .| .  |       | ...|.. .  ||.   | |.  ....   | . .  |      . |  
ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye......getrlithwlwkewpdwqvpessevmlki...lrkirarstpp..vihcsa

GVGRSGAFLCIHSQLERLKTEGEVDVFKYL-KTA-RTRRIGLLSELDHYVFCHEVLADYV
||||||.....   |. ...   .   | .      | |   .  |..|..  .|| |. 
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2201-2456 1.4e-11 38.6 In-house 33-279 (303) alignment 
Range on Protein: 2201-2456
Range on HMM: 33-279/303.0
GYKPSEMmySDGTTTVNVPKNRYPEIVPLNMHRPRLrpdgsNGSDYINASFVDGYKQRNAyIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEK
.| | ..  |      |. |||. ... |.  . .|       | || ||...   ...| |.|| ||  |  |||.||.| | . .. .    |  .  
sylppsv..sknqfvknmdknrfvdvicldhskvkl.....sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklg

CHMYWPTKEgEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREGHVvtqFHFTTWPEHGHPTS-TGSIIELI-DLLTRAQMNSGNKAITVVCND
 .. .| .. . ...    . .            .|..     |.     ||    |. .||    |.  .  ..  | .| .  .  | ..    .   
gdsvfprnq.dflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhv...hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GVGRSGAFLCIHSQLERLKTE-GEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
|.||.|.|  . .    |..|   .|. | |.. |  |.  . .|  . . . .||..|
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_PTPN12_pd Subfamily PTPN12 2203-2457 4e-62 204.7 In-house 25-278 (290) alignment 
Range on Protein: 2203-2457
Range on HMM: 25-278/290.0
KPSE-MMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGS-NGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEK
| .. .  . |....|| |||| .|.| .. |  |. . . .|||||||.|. | ... .|| .|||| .|.|||||||.|.... .|  |. || |. |
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CHMYWPTKEGEPVEYGRTKVTLQSEATTP-DYTTRKLHICNErggkseREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMnSGNKAITVVCNDG
|. ||| . .|..|.|  .|||..| ..  |.. | |.. ..      .| ..|.|||.| ||.|| |.|. |..|||.|. . |  | .. . | |  |
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaG

VGRSGAFLCIHSQLERLKTE---GEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
||| |. . |    | ||.|    |.|||. . . |..|  |    . |.. .. .|..|.
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2203-2457 9.1e-50 164.1 In-house 24-278 (287) alignment 
Range on Protein: 2203-2457
Range on HMM: 24-278/287.0
KPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCH
. | ...   . . .| |||| ...|..  |  |  .|  ||||||| .| .|.. .|.|..|||. .|| ||||...| .. ...     |||.. ||.
esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

MYWPTKeGEPVEYG-RTKVTLQSEATTPDYTTRKLHICNERGgkseREGHVVTQFHFTTWPEHGH-PTSTGSIIELIDL---LTRAQMNSGNKAITVVCN
 ||| .   |.  |  . | |. .   |.|..| | . .  .    || .|| |... .||...  ||. | |   .|    .  |.  |.   . | ..
kywPer.evPmrvGGysvvlldydikePeygvralrlidlet....rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhdd

DGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
 |.|||| .| .   ..||.  |.||| . .   | .| .|.     . .  | |. | .
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2203-2365 1.6e-15 51.4 In-house 82-234 (244) alignment 
Range on Protein: 2203-2365
Range on HMM: 82-234/244.0
KPSEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRpDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFcNTVEEGQEkch
.|   .  |     |  |||    .|... |  |   || |  |||||||    .   ||.|| ||  |  |||.|..| .   .| .  .||| .|   
rpdpsvmkdafnpnnswknregaglpfdfnrvpls.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.gsveeede...

mYWPtkEGEPVEYGRTKVTLQSeaTTPDyTTRKLHICNERGGKSEREGH-VVTQFHFTTWPEHG
 |||  . ||.|.    .|.    |  |   ....  |        | |  .| |  . ||  |
.ywp..dseplewyeeditvtl..tdrd.efknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2205-2266 1e-11 38.8 In-house 36-95 (95) alignment 
Range on Protein: 2205-2266
Range on HMM: 36-95/95.0
SEMMYSDGTTTVNVPKNRYPEIVPLNMHRPRLRpdGSNGSDYINASFVDGYKQRNAYIVTQG
|   |. |..  |.||||. .|.| .  |  |       |||||| ||||| ..|.|| .||
sgapytvgsseanipknrflnifpydatrvvlt..tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2206-2456 1.6e-30 101.1 In-house 31-277 (307) alignment 
Range on Protein: 2206-2456
Range on HMM: 31-277/307.0
EMMYSDgTTTVNVPKNRYPEIVPLNMHRPRLRPDGSnGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYW
| .  . . . |  |||| ..   .  |  .. ||   |||| | ..    . . .|..||||..|. .|| |... |  ... .|...| .. ||. ||
egvtve.afsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKS--EREGHVVTQFHFTTWPEHGHPTSTGSIIELIDlltraQMNSGNKAITVVCNDGVGRS
| .||.   .| .  |.  .    .  .   .. |    |    ..   .... .. ||..| |    . |.|..      ..  .  . | |  |||||
pleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle.....avrydtnpvvvhcsaGvGrs

GAFLCIHSQLERL-KTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
|. ..|    ... . .   |. | ..  |..|   . .   |.. | || .| 
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0045098 (Phosphotyrosine protein) phosphatases II 2207-2458 2.6e-66 219.1 In-house 23-274 (278) alignment 
Range on Protein: 2207-2458
Range on HMM: 23-274/278.0
MMYSDGTTTVNVPKNRYPEIVPLNMHRPRlrpdgsngsDYINASFVDGYkqRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWP
 .....    |..||||..|.|... | .         ||||||..|||  ....|.|||||..||.|||||. | ....||  .. || |.|||..|||
seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

TkeGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREGHVVTQFHFTTWPEHGHPTST--GSIIELIDLLTRAQM------------NSGNKAI
   |....||. .|||.|| ...|||.|.|...|    ... | . ||..|...||.|| |...   |..||.. . .|.             ..... .
e..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVVCNDGVGRSGAFLCIHSQLERLktEGEVDVFKYLKTARTRRIG-LLSELDHYVFCHEVLADYVES
 | |. ||||.|.. ...  ||.|  || ||.....|. |..| |  .  |..|.|..|.|..... 
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2207-2456 8.8e-30 98.4 In-house 45-289 (305) alignment 
Range on Protein: 2207-2456
Range on HMM: 45-289/305.0
MMYSDGTTTVNVPKNRYPEIVPLNMHrpRLRPDGSNGSDYINASFVDGYK-QRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYW
.. .. .. ... |||| ..   ..    .. |  . |||| | .|       . .|..||||  |.|.|| |... |   || .|.||| |. ||  ||
afnanqsadiaitknryqdvpcqdqs..avkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLtraqmNSGNKAITVVCNDGVGRSGA
|.  || .|     |  .   . |     ...|   .   |  .   | ....| ||. | |    . .||.  .        .  | | |  |.||.|.
paaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgt

FLCIHSQLERLKTEGEVDV-FKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 ..|   ||..  . ..    . .|. | .|   . .  .|.| | |. .|.
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2210-2456 3.3e-58 192.0 In-house 37-277 (315) alignment 
Range on Protein: 2210-2456
Range on HMM: 37-277/315.0
SDGTTTVNVPKNRYPEIVPLNMHRPRL-RPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTK
  . .|.| .|||| .|.||.  | .|   | |  |||||||.. .... .||| .|||||..|||||||... |. |||   .  |. . ||  ||| .
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

EGEPVEYGRTKVTLQSEATTPDYTTRKLhICneRGGKserEGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLtRAQMNSGNKAITVVCNDGVGRSGAFLC
... ||.|  ||.| |  .. | ..||| .   | ..   | . ||||.|| ||..| .  |.|...||  . .|. .. . .. | |  ||||.| .. 
kadsvefGsikvellsleadtdgvarkl.vt..rkse...esrtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGrtGvvis

IHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
|.. ....| .  ||||...|. |. |. |.   ..| | .... ...
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN13_pd Subfamily PTPN13 2210-2453 1.9e-48 160.1 In-house 30-266 (273) alignment 
Range on Protein: 2210-2453
Range on HMM: 30-266/273.0
SDGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSngsdYINASFVDG--YKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPT
. | .  |  |||| ...| .  | .|  .|.    |||||..     |..  ||..|||| .||.|||.|. | |.. |.   . .|.|. ||| ||| 
evgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

KEGEPVE-YGRTKVTLQSEATTPDYTTRKLHICNERGGKSeregHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMnsGNKAITVVCNDGVGRSGAF
......  ..| .|.|       ... |.|.. . . |.|    . |....|..||.|| |.|. ......  . | |    .  | | |  |.||||..
sknkklkvsnrlevellkvqkldgfvvralavkdsesges....revahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtl

LCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLA
..|.  |. .. . |.|| . ... | .| |..   | |.|..... 
itidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_eak_pd Subfamily eak 2210-2368 1.2e-20 68.2 In-house 45-196 (332) alignment 
Range on Protein: 2210-2368
Range on HMM: 45-196/332.0
SDGTTTVNVPKNrYPEIVPLNMHRPRLRPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKE
| .. . .| .|   .||| . .  || .   |   ||||| ..  .  . ||.|  . .. |  ||.|..| |. .|||. . ||.. ||   |.| | 
setarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

GEPVEYGRTKVTLQSEATTPDYTTRKLHIcneR-GgkseREGHVVTQFHFTTWPEHGHPT
 | ...|  .|. ..      . ||.| .   . |     | | |  ...  | |   | 
reelkfGildverkefvkrniletrllel...skG....nethrvlhykvfGwtettlpk
subfamily_PTPRD_pd Subfamily PTPRD 2211-2463 1.2e-87 289.8 In-house 42-288 (564) alignment 
Range on Protein: 2211-2463
Range on HMM: 42-288/564.0
DGTTTVNVPKNRYPEIVPLNMHRPRLR-PDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKe
  .  .| .|||| .||. .  | .|.  .| .|||||||||.|||..|.||| |||||..|..|||||..| ...|||   ...|.|..|||.|||.| 
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.

GePVEYGRTKVTLQSEATTPDYTTRKLHICNERggksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQmNSGNKAITVVCNDGVGRSGAFLCI
| . .||. .|||..| .  ||. |.. . ...    ..| . |.||||| ||.|| |.|. |...||.  .... ..... |.| |. ||||.|.|. |
g.tetygeltVtleeeeeladyeirtfklkkkk....ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

HSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYA
.. |||.|.|. ||...|.|. |. |  .  . . |.|.||..........   
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
0037934 (Phosphotyrosine protein) phosphatases II 2211-2455 1e-59 197.4 In-house 4-241 (243) alignment 
Range on Protein: 2211-2455
Range on HMM: 4-241/243.0
DGTTTVNVPKNRYPEIVPLNMHRPRLrpdgsNGSDYINASFVDGYKQrnaYIVTQGPLKTTVDD----FWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWP
 .   .|..||||. |.|..  | .|     .|||||||........   .|.|||||. ||.|    ||||. | ....|| ....|| |.|||..|||
iallpenlsknrysdilpydhsrvkl.....egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

tkeGEPvEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEregHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMN-------SGNKAITVVCNDG
   ||  .||. .||| || ...||| |.|...|   .. .   . |...|.. ||.|| |.|. ......| ..  . .       .... . | |  |
...gev.tygdftvtllseehlddytvrtlllenldlddlt...rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRSGAFLCIHSQLERLktegEVDVFKYLKTARTRRIG-LLSELDHYVFCHEVLADY
|||.|.....   |..|    .||.....|. |..| |     ...|.|..|.|. .
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2211-2458 8.3e-55 181.2 In-house 42-290 (325) alignment 
Range on Protein: 2211-2458
Range on HMM: 42-290/325.0
DGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNG-SDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKtRTIVQFCNTVEEGQEKCHMYWPTKE
  .   |. |||....|.|.  |. |   . .. |||||||..  .|... .. .| || .|..|.||......  ..|   | ...|...| .||| . 
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkem

GEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGkserEGHVVTQFHFTTWPEHG---HPTSTGSIIELIDLLTR-AQMN-SGNKAITVVCNDGVGRSG
|. ...|  .| |..  .  ||  |.|.. . ..|    |   | ||.. .|.. |   .|..  ||..|.. .    . |  .   | | | .||||.|
gksktfGglevklrtieeisdyvhrvldvkqvkkG....etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

AFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVES
.|....| |... .| .||.|...|  |  |  ..   | |....| |.... |
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2211-2450 3.9e-37 122.6 In-house 39-230 (392) alignment 
Range on Protein: 2211-2450
Range on HMM: 39-230/392.0
DGTTTVNVPKNRYPEIVPLNMHRPRL-RPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQfCNTVEEGQekchmywptke
 . . .|..|||| .|.|..  | .|   | .. |||.|||....... .||| .|||  ...||||||...... ||.   . ..||.           
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam.vtklkegd...........

gepveygrtkvtlqseattpdyttrklhicnerggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLtRAQMNSGNKAITVVCNDGVGRSGAFLCI
                                       . . |.||||| ||... |  | |....|  . .|.  .  . . . |. ||||.|  ..|
....................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisi

HSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHE
 | . . |.   ||||...   | .|  ..   ..| | . 
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyg
subfamily_CG42327_pd Subfamily CG42327 2211-2377 8.1e-30 98.6 In-house 22-187 (319) alignment 
Range on Protein: 2211-2377
Range on HMM: 22-187/319.0
DGTTTVNVPKNRYPEIVPLNMHRPRLRPDGSNGSD-YINASFVDGYKQ-RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTK
|   .   .|.|. ..|||   |. |.  |.. .| |..||.| ||.. .| || .| .|. .  ||||.. | ..|.||| ..  | | ..|  |.|||
devPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

EGEPV--EYGRTKVTLQSEATTPDYTTRKLHICNERGGKSeREghvVTQFHFtTWPEHGHPTSTGSIIELI
|. .    ||  .|||.  ..   | .  | . .  . .| ||   .| . .  |.| . |..  ..| ..
etldntslyGdilvtlkgrevkdryaistlllkrvdkees.re...lthywy.kwleaevPaeeaaliaml
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2212-2453 1.8e-44 146.9 In-house 43-276 (439) alignment 
Range on Protein: 2212-2453
Range on HMM: 43-276/439.0
GTTTVNVPKNRYPEIVPLNMHRPRL-RPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQekchmYWPTKEg
 .   . .|||| ......  |  |    |   | |||| ...|| . . || |||| | |.|||||...| || |||...| ||  .     |||... 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda.

ePVEYGRTKVTLQSEATTPDYTTRKLHICNERGgKSEREgHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIH
  | ||   |  . .   |.|. | ... |||  ..|.| . | |||...||..  |. .  .....  .  |. .     . | |  ||||.|. ... 
.evcygdiavrvdrnielpnyvirgfkvfnerd.tteke.rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiiald

SQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLA
  ||.||.| .||.   .|  | .|  .. .| .||| .. . 
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
0040439 (Phosphotyrosine protein) phosphatases II 2214-2456 4.8e-67 221.5 In-house 8-246 (249) alignment 
Range on Protein: 2214-2456
Range on HMM: 8-246/249.0
TTVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTkeGEP
  .|..||||| |.|.. .|..| . .| ..|||||||..|||.. ...|.|||||. ||.|||||. | . ..|| ....|| |.|||. |||.  |..
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggs

VEYGRTKVTLQSEATTPDYTTRKLHICNErggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNS-GNKAITVVCNDGVGRSGAFLCIHS
.|||. .||| |. . .|||.|.|.. |      . | . |.....| ||.|| | |. .....|...  |. .   .. . | |..||||.|.|...  
leygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

QLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 ||.|..|..||.. ..|. |..| |    ...|.|..|.|....
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 2214-2456 8.9e-67 220.4 In-house 6-243 (245) alignment 
Range on Protein: 2214-2456
Range on HMM: 6-243/245.0
TTVNVPKNRYPEIVPLNMHRPRLRPDGSN-GSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTkeGEP
  .|..||||..|.|..  | .| |||.. .|||||||.||||.. . .|.|||||. ||.|||||. | . .||| .....| |..||. |||.  ||.
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

VEYGRTKVTLQSEATTPDYTTRKLHICNErggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQ
..||. .||| || . .|||.|.|.. |.     . | . |...|.. ||.|| |... ......... .|. ...|. . | |..||||.|.|...   
ltygdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
||.|..|..|.... .|  | .| |    ...|.|..|.|....
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_CG7180_pd Subfamily CG7180 2214-2456 1.1e-57 190.0 In-house 39-290 (296) alignment 
Range on Protein: 2214-2456
Range on HMM: 39-290/296.0
TTVNVPKNRYPEIVPLNMHRPRLR-PDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQeKCHMYWPTKEgeP
 . |  |||....|| .  |. |.  || . ||||||..||.. . ..||||..| | |||.|||.. . .. ..|  ..| .  . ... ||| |    
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..k

VEYGRTKVTLQSEATTPDYTTRKLHICNE------RGGKSEREGHVVTQFHFTTWPE-HGHPTSTGSIIELIDLLTRAQMNS----GNKAITVVCNDGVG
 .||   | . .| . .. ..|....  .      .  . . |  .|..|..|.|.  .  | || ..|||.      . .      .. . ||..||..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
|||..| |   || .. |.|||||...|| |  | .|. . ..| .. .|| ..|
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2214-2458 1.7e-49 163.6 In-house 48-286 (297) alignment 
Range on Protein: 2214-2458
Range on HMM: 48-286/297.0
TTVNVPKNRYPEIVPLNMHRPRLRPDGSN-GSDYINASFVDGYKQrnAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFcNTVEEGQEKCHMYWPTKEGEP
  || .|.||  |.| .. | .|.  ...  |||.||||| |.|.   .| || | |.||.|||.|... .. |||   |  .|...||  ||. |   .
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml.nddnerdkkcaryWsdkgvtt

veYGRTKVTLQSEATTPDYTTRKLHICNERggksEREGHVVTQFHFTTWPEHGHPT--STGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIH
  .|   |.|.| .    .  |.|.. ...     .  .|| |..|. ||..  .   |. |...||. .     .  .  . | |  |||| | .| | 
..fGdvsvvllsvsereGfikrelevtkgk....akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltid

SQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVES
| . . | | |||.|...|  |  |  |.   ..| | .... ... |
svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0049772 (Phosphotyrosine protein) phosphatases II 2214-2459 2e-34 115.2 In-house 43-283 (314) alignment 
Range on Protein: 2214-2459
Range on HMM: 43-283/314.0
TTVNVPKNRYPEIVPLNmHRPRLRPDGSNGSDYINASFVDGYkqrNAYIVTQGPLKTTVDDF----------WRMI--MEFKTRTIVQ------------
  .|  ||||..|.| . .| .|   . .||||||||.|||.   ...|.|||||. ||.||          |||.   ....|.||             
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------FCNTVEEGQEKCHMYWPTKEgepveygrtkvtlqseattpdY-------TtrklhicnerggkserEGHVvTQFHFTTWPEHGHPtSTGSI
         ...  . | | . ..... .                                              |...  ... . .| .. | ..  .
LdaAlgKtpllildgngneptaadlellk.....................eelydpelf................erlg.ikylripvpDgsap.lledf

IELIDLLTRAqmnSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTeGEVDVFKYLKTARTRRI--GLLSELDHYVFCHEVLADYVESF
 |..... .|   . .... | |..|.||.| |...   . .|.     ....... .|. ..  |..  |..|.|..|.| .|.. .
deflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2215-2464 2.2e-71 235.0 In-house 7-250 (250) alignment 
Range on Protein: 2215-2464
Range on HMM: 7-250/250.0
TVNVPKNRYPEIVPLNMHRPRLRPDG-SNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEkCHMYWPTKEgePV
  |  |||| .|..|.  |  | ..   . ||||||||..||..|.|.|.|||||..|. |||||..| |. ||| . | .|.... .| |||...  . 
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..ae

EYGRTKVTLQSEATTPDYTTRKLHICNErggkSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQL
.||  .|.| |. .  |||.||| . ..    .. .  .| |.||..||. | |  . ...||.. . . | ..||. . | |  ||||||||. |.. |
kyGdvtvsllskeefadytkrklklska....kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

ERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVESFDPYAN
||||.|  |||||..|. |. |.. .  |. |||..|..  ...|.. ||.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2215-2454 6.8e-59 194.7 In-house 23-253 (284) alignment 
Range on Protein: 2215-2454
Range on HMM: 23-253/284.0
TVNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCntveegQEKCHMYWPTKEGEpv
  |  |||. .|.. .  . .|.. .| ..||||||||. ||.... || |||||. |..|||||| |... ||| .       ..||  ||| |  .  
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi..

EYGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREghvVTQFHFTTWPEHGHPTSTGSIIELIDLLT-RAQMNSGNKAITVVCNDGVGRSGAFLCIHSQ
...| || ..|   . .|. |.... ..   |  |.   ..||||  ||..| | ..  .. |.. ..   . . ... | | |  ||||.|......  
keerfkvkvdsveeseeyvvrdielsedgkekdirk...irqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

LERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLAD
|.|.| |  |||.....  | .|  |. .|  | |..  | .
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2215-2456 9.2e-55 180.7 In-house 41-276 (515) alignment 
Range on Protein: 2215-2456
Range on HMM: 41-276/515.0
TVNVPKNRYPEIVPLNMHRPRL-RPDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPV
 .| .|||| .|.|..  | .|   . .  |||.|||.. ...  .||| .|||.|..||||||.... .. ||.   .  |. . ||  ||| | |. |
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

EYGRTKVTLQSEATTPDYTTRKLHICneRGGKsereGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLtRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQL
..|  || | |  .  . . |||..   .| .     . ||||||| ||..| |  | |.. ||  . .|. .  . .. . |  |||| | .. |.| .
kfGsikvelvsleactggikrkltvl..kgdd....srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvv

ERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
 . ||   ||||....  | .|  |.   ..| | .... ...
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2215-2457 8.4e-51 167.6 In-house 26-269 (274) alignment 
Range on Protein: 2215-2457
Range on HMM: 26-269/274.0
TVNVPKNRYPEIVPLNMHRPRLRPDGSNG--SDYINASFVDGYKQ-RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGE
. .  |||| .|.| .  |  |... |.   |.|||| .. ||..  .||. ||||| .||.|||||| . ... ||   .  |. ..||..|.|..|. 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--PVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSereghvVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNK--AITVVCNDGVGRSGAFL
    .||  ... ..  .. ||. ||| . .    .|      |. . .| ||.|  | .. ....|..   ... .. .|  .. | |  |.|| |.|.
eiserygdveikvekiverndysvrklvlkylerers......vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

CIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
 |.  . .|. |. |||.|     |  | |.. . . | . |..|. |..
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2215-2450 1.9e-39 130.2 In-house 6-235 (239) alignment 
Range on Protein: 2215-2450
Range on HMM: 6-235/239.0
TVNVPKNRYPEIVPLNMHRPRLRPD-GSNGSDYINASFVDGYKQ-RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEgep
 ||  |||| .||  .  |  |        |||||||..  |    .||| ||| ....  |||||. . .   || .   .|  ..||| |||      
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...

VEYGRTKVTLQSEATTPDYTTRKLHICnERGGKSEReghVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMnSGNKAITVVCNDGVGRSGAFLCIHSQ
 .|   .|||.      ||  | . .  . |   ||    | |.||| ||..| |  . ... |   .|.  .  | .   . |. ||||.|||| | . 
skycnlrvtlrktevfadyiirtfvms.qvgqteer...yvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

LERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHE
| . | .  ||.|.|.|. |  |  ..   ..||| | 
lrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2215-2450 2e-39 130.2 In-house 5-234 (239) alignment 
Range on Protein: 2215-2450
Range on HMM: 5-234/239.0
TVNVPKNRYPEIVPLNMHRPRLRPD-GSNGSDYINASFVDGYKQ-RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEgep
 ||  |||| .||  .  |  |        |||||||..  |    .||| ||| ....  |||||. . .   || .   .|  ..||| |||      
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...

VEYGRTKVTLQSEATTPDYTTRKLHICnERGGKSEReghVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMnSGNKAITVVCNDGVGRSGAFLCIHSQ
 .|   .|||.      ||  | . .  . |   ||    | |.||| ||..| |  . ... |   .|.  .  | .   . |. ||||.|||| | . 
skycnlrvtlrktevfadyiirtfvms.qvgqteer...yvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

LERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHE
| . | .  ||.|.|.|. |  |  ..   ..||| | 
lrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2215-2451 2.2e-28 94.0 In-house 31-290 (297) alignment 
Range on Protein: 2215-2451
Range on HMM: 31-290/297.0
TVNVPKNRYPEIVPLNMHRPRLRpDGSNGSDYINASFVDGYK--QRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEP
   . |||| .|.  .  | .|.  .  ..||||| .|   .  .   ||..||||..||||||....|   |.||  ..  |.|..||  |||  ..| 
nsslrknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VEYGRTKVTLQSEaTTPDYTTrkLHIcNERGGKSEREGHVVTQFHFTTWPEHGHPTST-----------------GSIIELIDLLTR---AQMN------
 . |   |   |. |. .. .  ...  |       |  ||.   | .||.|| |.                     .. |....|     |..      
lkagdvvveflss.tsdefdr..vil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

SGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEV
  |  . | |  ||||||  .  .  |..|. .   ||   |.  | .|  |.  |. . .....
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_PTPRA_pd Subfamily PTPRA 2216-2455 2.7e-71 235.1 In-house 57-294 (330) alignment 
Range on Protein: 2216-2455
Range on HMM: 57-294/330.0
VNVPKNRYPEIVPLNMHRPRLRP-DGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKeGePVE
 |  |||...|.| .  |  | . .| . ||||||||.||||... .| .|||.. ||.|||||| |.|. ||| . .  |  .|||. |||.. |  | 
enkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvt

YGRTKVTLQSEATTPDYTTRKLHICNERGGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNkAITVVCNDGVGRSGAFLCIHSQLE
||  .|... |  . ||| ||. . .   .. |..  .|.|||||.||. | |. .  ...|.  . . . .|.. .|.| |  ||||.|.|. . . ||
yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

RLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADY
|.|.|. ||||. .|  |..|  ..  .  |.|...|| .|
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_egg_pd Subfamily egg 2216-2454 2.6e-20 67.3 In-house 39-268 (307) alignment 
Range on Protein: 2216-2454
Range on HMM: 39-268/307.0
VNVPKNRYPEIVPLNMHRPRLR-PDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEgqEKCHMYWPTKEGEPVE
 |  | | . .   .. | .|. . |    |.| |  |.|    | .|..| ||| ||||||||... . . || .  ..|   |.|. |||  | ... 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

Y--GRTKVTLQS--EATTPDYTTRKLHIcneRGGKsereghvVTQFHFTTWpeHGHPTSTGSIIELIDLLTRAQMNSgnKAITVVCNDGVGRSGAFLCIH
.  |  ...     ... | ..  ||..    ||.         . .   |   |    .. .   . .| ...  |  | . | . .|| .......| 
tvpGslrienlkvdskadplfrvtklkl...vGgd.......deerflehw..qgdvnnssdvysplrvlrklrnls..kpvvvqdilGvskaatlvaie

SQLERLKTE--GEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLAD
  |  |         | .  .  | ||   ..    |.| . ... 
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
Y_phosphatase Protein-tyrosine phosphatase 2217-2453 4.4e-70 231.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 2217-2453
Range on HMM: 1-234/235.0
NVPKNRYPEIVPLNMHRPRLrpDGSNG-SDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEY
|  ||||..|.| .  | .|  .||.| ||||||..|.|||. ...|.|||||| |..|||||... |...||. .. .|.|.|||. |||..|.|...|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GRTKVTLQ-SEA-TTPDYTTRKLHICNERGGKserEGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQmNSGNKAITVVCNDGVGRSGAFLCIHSQL
|. ||.|. .|   . .||.|||.. .. . .   | . |.|.|.|.||.|| |.|. |...||. . . . .. .. ..|.| .||||.| |...   |
gdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

ERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLA
|.|..|.||||....|. |..|.|. ..|. |.|......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2217-2453 4.4e-70 231.1 In-house 1-234 (235) alignment 
Range on Protein: 2217-2453
Range on HMM: 1-234/235.0
NVPKNRYPEIVPLNMHRPRLrpDGSNG-SDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEY
|  ||||..|.| .  | .|  .||.| ||||||..|.|||. ...|.|||||| |..|||||... |...||. .. .|.|.|||. |||..|.|...|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GRTKVTLQ-SEA-TTPDYTTRKLHICNERGGKserEGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQmNSGNKAITVVCNDGVGRSGAFLCIHSQL
|. ||.|. .|   . .||.|||.. .. . .   | . |.|.|.|.||.|| |.|. |...||. . . . .. .. ..|.| .||||.| |...   |
gdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

ERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLA
|.|..|.||||....|. |..|.|. ..|. |.|......
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 2217-2456 7.6e-37 122.0 In-house 1-171 (182) alignment 
Range on Protein: 2217-2456
Range on HMM: 1-171/182.0
NVPKNRYPEIVPLNMHRprlrpdgsnGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCntveegqekCHMYWPtkegepveyg
|..||||..|.| .. |         ..|||||....|.   . .|.|||||. || ||.||. | . .|||  .         ...|||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

rtkvtlqseattpdyttrklhicnerggksEREGHVVTQFHFTTWPEHGHPTsTGSIIELIDLLTRaqmnsGNKAITVVCNDGVGRSGAFLCIHSQLERl
                              |.. . ..|.... || || |. . .....|.   .      .... | |. ||||.|.. ..   ... 
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.

ktegEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
    .|.... .|. | || |    ...|.|.. .| ...
....gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2217-2456 1.4e-29 98.0 In-house 43-271 (288) alignment 
Range on Protein: 2217-2456
Range on HMM: 43-271/288.0
NVPKNRYPEIVPLNMHRPRLRpdgSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYG
|  ..|| ..   .. | .|     .   ||.|  |   | ..  | .| ||..|.. .|.|..|   . || .|. .| |.||   |.|.| || . .|
nptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

RTKVTLQSEAttpDYTTRKLHICNERGGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLtraqmNSGNKAITVVCNDGVGRSGAFLCIHSQLERL
|     . .    .   . ...   |  |   |  .| . |.  |...| | .  | . |.. |     .| .| | | .. ||||.|..  |   || |
rlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialesl

KTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYV
. .  . . . |.  |  |   .     |.. | .. ...
rlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2218-2452 5.5e-44 145.1 In-house 4-235 (237) alignment 
Range on Protein: 2218-2452
Range on HMM: 4-235/237.0
VPKNRYPEIVPLNMHRPRLRPDGSNgSDYINASFVDGYKQ-RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEgEPVEYG
  |||| .||  .  |  |.  ||. ||||||....|.    . || .||||... ||||.|. . |   || .   .|  ..||| |||  . .|  ||
kiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaayg

RTKVTLQSEATTPDYTTRKLHICNERGGKserEGHVVTQFHFTTWPEHGHPTSTGSIIELI-DLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLER
   |.|. .    ||| | | . ..   |   |  .. |..||.||..| |  | ... .  ... |..  |      . |. ||||.| || | . | .
vltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVL
 | .  ||...|...    |  ..   |.||| |...
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2218-2457 4.4e-31 102.7 In-house 49-288 (305) alignment 
Range on Protein: 2218-2457
Range on HMM: 49-288/305.0
VPKNRYPEIVPLNMHRPRLrpDGSNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEY--
  |||| ..  |.  | .|  .|.   .|| | .|    . . .| || ||. |  ||| | .. |  .|  .|| .| | .||. |...|... .|.  
agknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

GRTKVTLQSEATTP-DYT------TRKLHICNERGGKSEregHVVTQFHFTTWPEHGHPTSTGSIIELidlLTRAQMNSGnkAITVVCNDGVGRSGAFLC
.  |.... |...  ...       ..  .  |  |..    . ||..|.  ||. | |..  .|.||   |..|.   |   |.| |  |.||.|. . 
kgqkisvkfessvtlkfrkdakakvtetvlviegpgeka...rkvthyhwidwpdrgvpaadlailel...lekarpskg..pivvhcsagigrtgsvvm

IHSQLERLKTEGEVD-VFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
.   |..| .   ..   | |.  | .|   .   . |.| |.|. .|..
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2218-2309 4.9e-19 63.2 In-house 48-154 (350) alignment 
Range on Protein: 2218-2309
Range on HMM: 48-154/350.0
VPKNRYPEIVPLNMHRPRLR-----PDG----SNGSDYINASFVDGY----KQRNA--YIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCH
  |||| .|.| .  | .|.     .|.     ...|||||...       ..     || ||.||. |||||...|.. | . |.   . || . |||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

MYWPTKE
 ||.  .
rYWqegs
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2220-2457 6e-48 158.2 In-house 23-265 (270) alignment 
Range on Protein: 2220-2457
Range on HMM: 23-265/270.0
KNRYPEIVPLNMHRPRLRPDGS-NGSDYINASFVDGYKQ-RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGE--PVEY
 ||| .|.|    | || .  . . . |||| .| |... ...|| ..|||.||. .|||||.| |...||   . .|.|..|| .|||.. .|   .|.
lnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkled

GRTKVTLQSEATTPDYTTRKLHICneRGGKSEREGHvvtqFHFTTWPEHGHPTSTG------SIIELIDLLTRAQ--MNSGNkAITVVCNDGVGRSGAFL
|  ||. .||. .  | ...|..   . |...|  |    |...|||.|| |....      ......  . | .  .. ..  . | | .||||.| ..
gkikvlalseekeegyiltrlrle..ekgeerrlvH....fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtli

CIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLADYVE
 .   .. |.....||| . ..  |  |. |..  ..| | ..... |.|
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2220-2457 2.5e-18 60.8 In-house 46-277 (312) alignment 
Range on Protein: 2220-2457
Range on HMM: 46-277/312.0
KNRYPEIVPLNMHRPRLRPDgsNgSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEpVEYGRTK
 ||||.|   .  |  |  |  .   || | ||    . . ...|||||. |.  ||.. . . . .|. .|  ||.| |||  |     |  |.    .
lnrypniqcwdrgrftlagd..e.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdledhr

VTL------QSEAT-TPDYTTRKLHICNERGGKSEReghvVTQFHFTTWPEHGHPTSTGSIIELIDlltraQMNSGNKAITVVCNDGVGRSGAFLCIHSQ
|        .         | | |..     |.  .    . .. ...||.|| | |  .   |.       ..  .| .   |  ||||.|..  | | 
vyteycteieiggkskdkithrvlkvvvkatgqesk....lnhyqwaswpdhgmpdscdtalrlls.....avkkdkkpviahcsagvgrtgtlaliesm

LERLKTEGE---VDVFKYLKTARTRRIGLlseLDHYVFCHEVLADYVE
.  |.        |.|  |.  |.| .     . .||..  .. ... 
iaalrhprkqnvkdsfvllrkdrarsvrv...fpqyvyalrcvlefly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2220-2292 2.7e-08 27.7 In-house 40-118 (347) alignment 
Range on Protein: 2220-2292
Range on HMM: 40-118/347.0
KNRYPEIVPLNMHRPRLRPDGSN------GSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCN
|||  .    .  |  | |. |.         ||||| .   . .. ||.|| ||  || |||.|..  |   .|   .
knrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
0046846 (Phosphotyrosine protein) phosphatases II 2239-2455 3.1e-30 100.6 In-house 7-172 (176) alignment 
Range on Protein: 2239-2455
Range on HMM: 7-172/176.0
DGSNGSDYINASFVDGYKqrnaYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVeygrtkvtlqseattpdyttrklhi
   ...|||||....|..    .|.|||||  |. ||..|. | . ...| ... || |. ||. |||  |.. .                         
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

cnerggksereghvvtQFHFTTWPEHGHPTStGSIIELIDLLTRAQMNSgnKAITVVCNDGVGRSGAFLCIHsqleRLKTEGEVDVFKYLKTARTRRI-G
                |.... ||.|| |..   ..||.... .|. .   . . | |  |.||.|.....      |..|  ..|.. |.. | .|  |
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

LLSELDHYVFCHEVLADY
 .   ..| |..|..  .
avqtpeQyrflyefelll
0044763 (Phosphotyrosine protein) phosphatases II 2239-2451 2.1e-24 81.5 In-house 13-166 (178) alignment 
Range on Protein: 2239-2451
Range on HMM: 13-166/178.0
DGSNGSDYINASFVDGYkqrnAYIVTQGPlkttvDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGepveygrtkvtlqseattpdyttrklhi
 | ..|||||||.....     |. ...|      |..... | . ..|| .....| |..||. |||...|                            
eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............................

cnerggksereghvvTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMnSGNKAITVVCNDGVGRSGAFLCIHSQLERlktegEVDVFKYLKTARTRRIgL
                |.... .| || |...  . |..... .|.  . .... | |. ||||||.. ..   ...      ..... ..  | ||   
...............iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.i

LSELDHYVFCHEV
    ... ...|.
vpnpgqlrqLyef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2239-2323 9.9e-11 35.5 In-house 85-166 (349) alignment 
Range on Protein: 2239-2323
Range on HMM: 85-166/349.0
DGSNGSDYINASFVDG--YKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTkegepVEYGRTKVTLQ
|..   ||||| ..    ..  . || || || .|||||...|.  . . ..   .  |.. |||..||        .|   .| ||
dsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe.....lsysnitvklq
0043147 (Phosphotyrosine protein) phosphatases II 2241-2450 6.6e-30 99.5 In-house 2-155 (172) alignment 
Range on Protein: 2241-2450
Range on HMM: 2-155/172.0
SNGSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTveegqekchmywptkegepveygrtkvtlqseattpdyttrklhicn
 .||||||||..|.|   . .|.|||||  |..|||||. | . ..||  ..                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

erGGKSEREGHVVTQFHFTTWPEHGHPtSTGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLerlkteGEVDVFKYLKTARTRRIGLLS
      | . . . |.... || || | ..  ..|..... ... .| .... | |  ||||.|.. ...  |        ..... ... |..| |   
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

ELDHYVFCHE
  ..| |...
npsqyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 2243-2458 1.7e-40 134.7 In-house 3-227 (272) alignment 
Range on Protein: 2243-2458
Range on HMM: 3-227/272.0
GSDYINASFVDGYKQ---RNAYIVTQGPLKTTVDDFWRMiMEFKTRTIVQFCNTVEEGQEKCHMYWP----------TKEGEPVEYGRTKVTLQSEATTP
 |.||||..|.|| .   ..... ..|||. |..||||.  | . .||| .....| |..||..|||            . ....||.  |||.|| ...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYTTRKLHICNERGGKSEregHVVTQFHFTTWPEHGHPTSTgsIIELIDLLTRaqmnsgNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVD------
||. |.| . .. . .     . |...|.| || ||.|...  ..||..|| .      .... | |. |..|.| . ..   |...  |  ||      
dyilrellltlllsagea...revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VFKYLKTARTRRIGLLSELDHYVFCHEVLADYVES
  ......  | .| |     ..|.|..|.|.....|
lyleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 2243-2450 5.8e-38 125.7 In-house 1-164 (174) alignment 
Range on Protein: 2243-2450
Range on HMM: 1-164/174.0
GSDYINASFVDGYKQRNAYIVTQGPLKttvddFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTkegepveygrtkvtlqseattpdyttrklhicner
||||||||..|..   . .|..||||.     ||.|. |.. .|.|.... .| | .||. |||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

ggKSEREGHVVTQFHFTTWPEHGHPTSTGsIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKtEGEVDVFKYLKTARTRRIGLLSEL
  ..| . . . |.... || || |...  ..|..... .|. ..... . | |. ||||.|.. ..   | .|. |. ||........|. | |     
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

DHYVFCHE
..| |...
sQyrflyy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2243-2456 1.8e-15 51.1 In-house 74-285 (302) alignment 
Range on Protein: 2243-2456
Range on HMM: 74-285/302.0
GSDYINASFVDGYKQRNAYIVTQGPLKTTV---DDFWRMIMEFKTRTIVQFCNTVEEGQeKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTtRKLHIc
  .|.||| |.  . ..  |..| | ....   ..||||... |  ..|    . |  .   . ..|.| |. .|||.  |  .    . . .  .. | 
pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryvi.

nERGGKSEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLtRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLL
 |   .   .  ...  ..| |...  |.. ...|. .  .  |.  .... . .| . |.|| ||||     .|.|... |. .   .|. |. |   .
.EvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

SELDHYVFCHEVLADYV
  |. ||. . .|. |.
dslkQyvslyialllyi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2243-2365 2.6e-11 37.9 In-house 12-125 (130) alignment 
Range on Protein: 2243-2365
Range on HMM: 12-125/130.0
GSDYINASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFcNTVEEGQEkchmYWPtkEGEPVEYGRTKVTLQSEATTpdyTTRKLHICNER
| .|||||||    . . |. || ||  |  |||.|..|     .| .  .||| .|    |||  . ||.|.  ..... .         ....  | .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.gsveeede....ywp..dsePlewyeediivtltdrd...efknikasnle

GGKSERE-GHVVTQFHFTTWPEHG
. .   |  . .| |. . ||  |
iesdlneshqaltmfqisnwpsdg
0051082 (Phosphotyrosine protein) phosphatases II 2244-2451 1e-23 79.0 In-house 3-148 (151) alignment 
Range on Protein: 2244-2451
Range on HMM: 3-148/151.0
SDYINASFVDGYkqrnaYIVTQGPlkttVDDFWRMIMEFKTRTIVQFCNTVEEGqeKCHMYWPTKEgepveygrtkvtlqseattpdyttrklhicnerg
|||||.|.|.|.     .....||     .||.... | . .||| .....| |  .|. |.|  .                                  
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

gkseregHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRaqmnSGNKAITVVCNDGVGRSGAFLCIHSQLERlktegeVDVFKYLKTARTRRIGLLSELD
       . |...... ||..| |.|. ...|...|| .     .|. . | |. |.||.|.. ..   |..      |.... |.  | .| |.    .
.......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

HYVFCHEV
...|.. .
qflfqlfa
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2244-2448 2.1e-17 58.2 In-house 46-251 (290) alignment 
Range on Protein: 2244-2448
Range on HMM: 46-251/290.0
SDYINASFVDgYKQRNAYIVTQGPLKT-------TVDDFWRMIMEFKTRTIVQFCNTVEEGQE----KCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYT
.||| |..|  . .  . |.|| |..        |. .|| |... | . .|. |.  |. ..     |  | |...|| . ..  .|  .|  .  |  
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

TRKLHICNErggksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTraqmnSGNKAITVVCNDGVGRSGAFLCIHSQLERLK-TEGEVDVFKYLKTA
||.| .  .     ..| . ||   .  | .   . .| ....||. .        . .. | | ||. || |.  |      .  |.|.| . . ||. 
tRelvvkfd.....deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RTRRIGLLSELDHYVFC
| .|  ....   . | 
rkqralaitsalelafv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2247-2435 1.3e-28 94.6 In-house 78-260 (301) alignment 
Range on Protein: 2247-2435
Range on HMM: 78-260/301.0
INASFVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATT--PDYTTRKLHICNERGg
| | ...   . . .|.|||||| | .||| |.. ..  .|| ....||. .|||. | |.| .| .. || |...... .    . . |.|.. .  | 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg.

ksEREGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAqmnsgNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRR
  . . . || . ...|...| | |   . .|..|. ..     .| | | |..|.||| ||.  .    ..... .... . ||  | .|
..kfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehr
0049260 (Phosphotyrosine protein) phosphatases II 2251-2450 6.8e-28 92.7 In-house 1-144 (152) alignment 
Range on Protein: 2251-2450
Range on HMM: 1-144/152.0
FVDGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWptkegepveygrtkvtlqseattpdyttrklhicnerggksereg
|.|||.. ...| ||||.  |..|||||. | . .|||  .. .| | .||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

hvvtQFHFTTWPEHGHPTSTGSIIELIDLLTRAqMNSGNKAITVVCNDGVGRSGAFLCIHSQLerlkteGEVDVFKYLKTARTRRIGLLSELDHYVFCHE
    |.... || || |...  ...|.... ..   . .. . | |  ||||.|.. ..   |        |.......  |..| |     ... |..|
....qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2253-2316 1.5e-10 35.0 In-house 230-289 (440) alignment 
Range on Protein: 2253-2316
Range on HMM: 230-289/440.0
DGYKQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFcNTVEEgqEKCHMYWPTKEgEPVEYG
.|| ..||.| || || .|| ||||.. ...  ||. . | ...    | .||| .    | .|
egyskknafiatqmpldstvldfwrlvhdyristiiml.nqlnd..ktcsiywpvnt.rsvtfg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2256-2450 2.4e-21 70.8 In-house 2-198 (199) alignment 
Range on Protein: 2256-2450
Range on HMM: 2-198/199.0
KQRNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERG-GKSEREghvVT
| .  ||.|| ||. |. |||.|. |  .  ||   .   . .    .|||| |    .||   || .. .| ||||   | ..|.     | ||   ..
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstre...is

QFHFTTWPEHGHPTST---GSIIELIDLlTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQL---ERLKTeGEVDVFKYLKTARTRRIGLLSELDHYVFC
.. ||.| |.  |  .   | ..   .. ..   .  .  . | | || | .| |...   .   |  ||   ||.|.  |  |  | |..| |.|| | 
hyqftswkekttpnvalfvgfvvasrev.skkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi

HE
..
yq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2256-2435 5.4e-21 69.8 In-house 32-200 (255) alignment 
Range on Protein: 2256-2435
Range on HMM: 32-200/255.0
KQRNAYIVtqgplktTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSeaTTPDYTTRKLHICNERGGksEREGHVVTQ
|..| |..       ||| |...|.  || ..| .|.  |||.|||. |.|..  |   .   .||     .. |   | |.|  . |    .. | |. 
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlge..kkkthtvkh

FHFTTWPEHGHPTSTGSIIELIdlltRAQMNSgnKAITVVCNDGVGRSGAFLCIHSQLE----RLKT--EGEVDVFKYLKTARTRR
.... |.|.  |  .  | ...    ..  .|  |.. |.|. |.||| ||  . .        |.|   .|.|  . |.  | .|
ysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskr
subfamily_hpo-7_pd Subfamily hpo-7 2256-2432 4.8e-20 66.5 In-house 35-203 (263) alignment 
Range on Protein: 2256-2432
Range on HMM: 35-203/263.0
KQRNAYIVtqgpLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATtpDYTTRKLHICNERGGksEREGHVVTQ
|..| |..    |  |.| |...|   || ..| .|.  |||.|||  |.|..  |   .   .|.        |   . |.. .  |    .. | |..
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge..Kkkthtvkh

FHFTTWPEHGHPTSTGSIIELIDLLTraqmNSgnKAITVVCNDGVGRSGAFLCIHSQLE----RLKT--EGEVDVFKYLKTAR
. .. |.|.  |. . .|...... .    ||  | . |.|. |.||| ||  . .        |.|   .|.|  . |.  |
ysykgWiekndpelareilnilkvar....ns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelr
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2258-2450 3.2e-21 70.4 In-house 3-197 (198) alignment 
Range on Protein: 2258-2450
Range on HMM: 3-197/198.0
RNAYIVTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERG-GKSEREghvVTQF
.  ||.|| ||. |. |||.|. |  .  ||   .   . .    .|||| |    .||   || .. .| ||||   | ..|.     | ||   ....
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstre...ishy

HFTTWPEHGHPTST---GSIIELIDLlTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQL---ERLKTeGEVDVFKYLKTARTRRIGLLSELDHYVFCHE
 ||.| |.  |  .   | ..   .. ..   .  .  . | | || | .| |...   .   |  ||   ||.|.  |  |  | |..| |.|| | ..
qftswkekttpnvalfvgfvvasrev.skkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2263-2438 1.5e-19 64.6 In-house 95-270 (302) alignment 
Range on Protein: 2263-2438
Range on HMM: 95-270/302.0
VTQGPLKTTVDDFWRMIMEFKTRTIVQFCNTVEEGQEKCHMYWPTKEGEPVEYGRTKVTLQS-EATTPDYTTRK------LHICNERGGKseREGHVVTQ
.   | | |.. .| .| ....  .||.|. ||....||  |. .| |. ...||  |.  | .    ..| .|      . | ||.  |  .  . |  
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk..kvkktvdi

FHFTTWPEHGHPTSTGSIIELIDLltraqMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGL
..|..||.|| |  . . ....        .|  |.. | |  ||||.|... |   ..  ...   |. . ..  |. | | 
lafsawpdhGapkeaytaldilkf.....cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGa
0048076 (Phosphotyrosine protein) phosphatases II 2304-2453 6.5e-14 47.3 In-house 2-140 (145) alignment 
Range on Protein: 2304-2453
Range on HMM: 2-140/145.0
YWPTKEGEPVEYGRTKVTLQSEATTPDYTTRKLHICNERGGKSeregHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNsgNKAITVVCNDGVGRS
|||..  . . .|   ..|. |       |. | ...|. . .    . ..|.... || || |...  ..|..... .|. .  .. . | |. ||||.
ywpseilpglylgslptaldlellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRt

GAFLCIHSQLErlktEGeVDVFKYLKTARTRRIGLLSELDHYVFCHEVLA
|.. ...  |.    .| |.... |.  |..| |     ... |..|.. 
gtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 2334-2450 5.4e-14 47.6 In-house 48-139 (144) alignment 
Range on Protein: 2334-2450
Range on HMM: 48-139/144.0
RklhicnerggksereghvVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMnsGNKAITVVCNDGVGRSGAFLCIHsqleRLKTEGeVDVFKYLKTART
                   ..|.... || || |...  ..|..... .|.    .. . | |. ||||.|.. ...    ..|..| ..... |.  |.
e..................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrs

RRIGLLSELDHYVFCHE
|| |     ... |..|
rrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2349-2454 2.6e-14 47.4 In-house 87-192 (440) alignment 
Range on Protein: 2349-2454
Range on HMM: 87-192/440.0
EGHVVTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSGNKAITVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFC
| ... |.|.  ||..| |  .| ....|. .  .| ..||  . | |. |.||.|  ... | |   |   ..|.| .... |  |  ..   ..|.| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HEVLAD
||.. .
heavle
PTPc_DSPc_SM00012 2353-2453 1.8e-23 78.1 In-house 2-104 (105) alignment 
Range on Protein: 2353-2453
Range on HMM: 2-104/105.0
VTQFHFTTWPEHGHPTSTGSIIELIDLLTRAQMNSG-NKAITVVCNDGVGRSGAFLCIHSQLERLKTE-GEVDVFKYLKTARTRRIGLLSELDHYVFCHE
|...|.|.||.|| |... ||.||.. . . . .|. .| . |.| .||||.| | ..   |..|..| .|||.|...|  |..| |. .... |.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLA
.|.
all
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2393-2454 5e-08 27.2 In-house 2-63 (69) alignment 
Range on Protein: 2393-2454
Range on HMM: 2-63/69.0
TVVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLAD
 | |  | ||.|.|..|  .. |.|.|  ||.|  ..  |  |  .. .   |.| |. |..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2394-2454 5.7e-08 27.0 In-house 2-62 (69) alignment 
Range on Protein: 2394-2454
Range on HMM: 2-62/69.0
VVCNDGVGRSGAFLCIHSQLERLKTEGEVDVFKYLKTARTRRIGLLSELDHYVFCHEVLAD
| |. | ||.|.|. |  .. |.|.|  ||.|  ..  |  |  .. . . |.| |. |..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve