Gene PTPRD-5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP106_AA protein Get Run
AqueP106_AA_485-761 phosphatase_domain Get Run
AqueP106_AA_772-1024 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Death Death domain 45-111 3.3e-08 21.3 Pfam-A 17-80 (83) alignment
Range on Protein: 45-111
Range on HMM: 17-80/83.0
ELGLYLQLHDNTLKSIEQEYRGkVDRCFIECLGSWLRKadDVENPTIDTLIVALRGMGENAVADGIN
||.  |.| ......||.|... .     | | .|  .    .| |...|. ||| .| . .|. ..
eLarkLglsedeideiesenpr.lreqtyelLqlWeqr..egknatlgaLleaLrklgrrdaaekle

subfamily_PTPRB_pd Subfamily PTPRB 482-758 2.5e-83 274.5 In-house 6-283 (293) alignment
Range on Protein: 482-758
Range on HMM: 6-283/293.0
NVQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPS
... ..|.|||........  |.| .|....   | ...|.  |.  ...|||...| ..||.|| |... . ..| |||||||.||   . .|||| | 
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelav..nraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

KETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSD-DEVCYGDIVVRADRNIELPNYVIRGFKVFNkrdrGKKERTILQFHYITWPNKNVPAQAS
 || |.|||||||.|. .|||||..|.  |     |||.| ..| |||| |    . || ..||| .|. .    .|.||.. |.|...||. .|| ...
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektk

HVLDFMRAINSAN-DSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 .|||.|....|  .... .|.||||||||||||| ||||  |.....|. ||| |||  ||..|...||   |..||...||.
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 483-775 1.5e-187 618.4 In-house 2-294 (439) alignment
Range on Protein: 483-775
Range on HMM: 2-294/439.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
|.|.|||||||.|.||.||.||||||.||||||||.|.|.|.|||||.||||.||.||||||||.|||.|||||||||||||||||||||||||||.|.|
vgrdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkk

ETCDNFWRMVWEQKTVTIVMLTNVVDSFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMR
||.|.|||.|.|.||||||||||.|.|.||||||.|||||||.||.||||||||||||||||||.||...||||.||||||.||.|||||||||||||.|
ettddfwrlviekktvtivmltnlvesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflr

AINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNH
|||||||..|.||||||||||||||||||||||||||||.||.|||.|||||||.||.||||.|||.|||||||||||||||....|||| ..
ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke

subfamily_PTPRD_pd Subfamily PTPRD 483-795 2.7e-105 348.2 In-house 5-321 (564) alignment
Range on Protein: 483-795
Range on HMM: 5-321/564.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTsPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
.. .|..|||..|..|..  |.| ...|..  .  ...|  . .     |||...| |.||.||||....|.. |.||||..|.||  .| ||||| | .
ipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpa..NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWPNKNVPAQASHV
||...||||||||.. ||||||..... |     |||....  ||...|    . || .|.|| ||.  |. . .. |.. |||.. ||...|| .| ..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatsl

LDFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYI
||..| ....| ... ||.||||||||||||| |..|. ||..|.|. ||| ..|| ||.||  |||. .|..||..|.|| .  |. .  ......|  
Ldlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

K-----SQEEATLITDEFNKIGA
|     ...| | .  ||... .
kLaeveedtemtgleleFqrLat

0051299 (Phosphotyrosine protein) phosphatases II 483-758 5.8e-90 296.9 In-house 5-284 (288) alignment
Range on Protein: 483-758
Range on HMM: 5-284/288.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDykCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
.. .|. ..|..| .|.. ...| || . |  ||  .. .  . .  ..|||..|| ..||.||.|. ..||..| ||||.||.||. .. .||||.| .
isveellklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNK--RDRGKKERTILQFHYITWPNKNVPAQAS
.|...||||||||.. .|||||..|.     ...|||... ..||||.|.  .  .|..|..| ..| |.   | ....||. .|||..||. .||  ..
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

HVLDFMRAINSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
..|||.|....|.  .  ||||||||||||||||.||||..||||. |..||....|| ||.|| .||| ..|..|.| |.||
llldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 483-782 6.8e-89 293.0 In-house 2-302 (318) alignment
Range on Protein: 483-782
Range on HMM: 2-302/318.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
..  ....||..|... . ...| .| .. ..       .   .. ...|||. .| |.||||| ||.. |.. | ||||||| ||  .| |||.| |  
isvedleshvrrlresGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlp

ETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNkrDRGKKERTILQFHYITWPNKNVPAQASHV
||...||||||||.. .|||||.....      .||||..   ||..|| .. ..|| .||.| ||| .  .  ...|.. |.|| .||...||......
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgasl

LDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYI
||..| ...|. ... ||.||||||||||||. ||.|| ||..| |. ||. ..|| ||.||  |||   |..|||...|| .  ||. .  ......  
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

KSQEE
. .|.
elreq

subfamily_Ptp69D_pd Subfamily Ptp69D 483-776 5.9e-83 273.5 In-house 4-302 (307) alignment
Range on Protein: 483-776
Range on HMM: 4-302/307.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTspDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
... . .| ... ... .. ... .|.....    . ...  ... .  |||..|| |||.|||.|....|  .| ||||..|||| . | .|| | |  
iaiddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRG---KKERTILQFHYITWPNKNVPAQA
.| ..||||..||.  .||||.|. .  .     ||| .||| ||||.|.  .. . ..|.|| ..| .| . .   ...| ..|.|| .|.. .|| .|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

SHVLDFMRAINSANDSKeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSN
  .|.... ... .  .  .|.||||||||||.|...|||. |.||| |..|||  .|| ||.||. .|| | |.||.| |.|. . |||    .|....
rgllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

HY
..
ai

0050432 (Phosphotyrosine protein) phosphatases II 484-761 1.5e-85 282.6 In-house 27-300 (308) alignment
Range on Protein: 484-761
Range on HMM: 27-300/308.0
QRTEFQEHVEQlnKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLqetpGvPHSHYINANYIKGY--YDDKLYIATQYPS
   .. ...|.  ...  ...| || ..|. |.......  ...  ..|||.||| ..||.||.|    . ..|.||||.|..||  . .. .||||.| 
svldllkllek..aldlglleeefeellsvkplleysva..llpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl

KETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSD---DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQ
..|...||||||||.. .|||||. |.      ..|||..   . ..||...|.  .  .|..|..| ... |..|   ..||. .|||..||. .|| .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPps

ASHVLDFMRAINSANDSkecGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
....|||...... ...   ||.|||||||||||||.||||..||||. |..||....|| ||.|| .||| . |..|.| |.|| . 
peilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0043336 (Phosphotyrosine protein) phosphatases II 484-758 4.9e-81 267.5 In-house 3-275 (278) alignment
Range on Protein: 484-758
Range on HMM: 3-275/278.0
QRTEFQEHVEQLNKNNQEMFKEIFESINSTSPdykCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKE
.. ........|..|.. .... ||...|  .   .. .  . .  ..|||.||| ..||.||.|. ..|...| ||||.|..||   . .||||.|..|
svkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPsDDEVCYGDIVVRADRNIELPNYVIRGFKVFNkrDRGKKERTILQFHYITWPNKNVPAQASHVL
|...|||||||... ||||||. |.     ...||| .. ..|||..|.  . ..|..|..| ..| |   . ...||....||. ||  .|| . |..|
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslslll

DFMRAINSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
||..|...|.. .. |||.||||||||||||.|||...||||..| .||.| .|| ||.|| ..|| . |..|.|.|.||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 484-759 1.3e-79 263.1 In-house 15-288 (297) alignment
Range on Protein: 484-759
Range on HMM: 15-288/297.0
QRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDykcdATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGV-PHSHYINANYIKGYYD-DKLYIATQYPS
. . .  ..  ...|.  .... ||.. |  ||     .  . .   .|||.||| ..||.||.|.  .|| ..| ||||.|..||.  .. .||||.|.
plsvldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

KETCDNFWRMVWEQKTVTIVMLTNVVD----SFKYWPSDDEvCYGDIVVRADRNIELPNYVIRGFKVFNkrdrGKKERTILQFHYITWPNKNVPAQASHV
.||...||||||||.. .|||||. |.     ..|||.. . .|||..|.  . ..|..|..| ..| |    ....||. .|.|. ||  .||  ....
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslell

LDFMRAINSANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
|.|......|. .  . |||.||||||||||||.||....||||..| .||.. .|| ||.|| ..|| . |..|.|.|.|| 
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

subfamily_PTPRK_pd Subfamily PTPRK 484-790 1.7e-76 252.1 In-house 5-312 (314) alignment
Range on Protein: 484-790
Range on HMM: 5-312/314.0
QRTEFQEHVEQLNKNNQEMFKEIFESINSTspdykCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKE
.  .  ... .|....   ||| .||.         ||.   .. ...|||..|| |.|..||.|. . | |.| ||||..| .|   . .|.||.| .|
rvadllqsiallkraegygfkeeyeslfeg.....wdaa..kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe

TCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVcYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVL
|  .|||.|..... .|||||..|. .     |||| | || |||| |   .   | ..|.| |.| .     .. |.. ||....||. .|| .|  .|
tvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

DFMRAINSANDSkECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIK
...| ... ..  | |..||||||| ||||| ||.|| |. .. |. ||.  .|| ||.... ||.   |..|||...||  . |. .  . || . |..
klvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

S-----QEEATLITDEF
|     | ... . .||
sirldpqtnssqlkeef

subfamily_PTPN6_pd Subfamily PTPN6 484-758 7.5e-71 233.6 In-house 5-295 (306) alignment
Range on Protein: 484-758
Range on HMM: 5-295/306.0
QRTEFQEHVEQLNKNNQEM----FKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQeTPGVPHSHYINANYIKGYY--DDKLYIAT
  .| ...|..|.|.....    |.| ||... .   .. . .  |.   ..|||.| |  ||||||.|.  |.|| | ||||||||.     || ||||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiat

QYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE-VCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVP
|   ..|  .||||||....  |||.|. |.       .|||.  |   ||.| |.  .. .| .|..| ..| .| ...|.||.. |.|. .||...||
qgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvp

AQASHVLDFMRAINSANDSKE---CGPVVVHCSAGVGRTGTIIALDIALEQLKS---ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.. ..||||.. .|. ... |    ||.|||||||.|||||.| .|| |.....   .  .||. .||..|.|| ..||   |. |.|.|. .
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 485-773 3.6e-85 280.9 In-house 7-296 (319) alignment
Range on Protein: 485-773
Range on HMM: 7-296/319.0
RTEFQEHVEQLNKNNQEMFKEIFESINSTSPDykcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKET
  |..|....|... . .... |. .. ...|   . .   .| ...|||...| |.|.|||||.| .||. | ||||..| || . . .|||| | ..|
vqeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

CDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVfNKRDRGKKERTILQFHYITWPNKNVPAQASHVLD
 ..|||||||... ..||||..|.       ||||. . . || ..|  . . || .|.|| .|. ||.    . |.. .|.|  ||...|| .|  .||
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslld

FMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFS
... |. . . .. ||.||||||||||||| |.||..||..| |. .|.  .|. || ||  |||.  |. |||.|.|| .  ||    .... 
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlr

0045450 (Phosphotyrosine protein) phosphatases II 485-758 6.6e-80 264.4 In-house 11-302 (307) alignment
Range on Protein: 485-758
Range on HMM: 11-302/307.0
RTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGV-PHSHYINANYI--------KGYYDDKLYI
.. .  .| .| ... . ... ||...|  ... .. .  . .  ..|||.||| ..|||||.|. ..|  ..|.||||.|.        .||. .. .|
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

ATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEV-CYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKN
|||.| .||...||||.|||.. .|||||. |.      ..|||...|. .||...|.  .  .|..|..| ..| .. |  ...||. .|||..||. .
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhg

VPAQASHVLDFMRAINSANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR---VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
||   ...|||......|...  . |||.||||||||||||.||....|.||..|.    ||.. .|| ||.|| ..|| . |..|.|.|.||
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 486-767 2.8e-80 265.1 In-house 4-294 (563) alignment
Range on Protein: 486-767
Range on HMM: 4-294/563.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHS-HYINANYIKGYYDDKLYIATQYPSKET
 ||..|| .|  ...  |.| ||...|.. . . ||.   .. .. |||  .| |.|..|| |...||. ..  |||||||.||.  | .||||.|.|.|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

CDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFN-KRDR---GKKERTILQFHYITWPNKNVPAQAS
.| ||||.|||.. .|||.||.|     . . |||.|. . || . |.  ..  |  | .| ... | | ..    ..|... |.|| .||...|| .. 
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

HVLDFMRAInSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMST
 || |..   ||   .| ||.||||||||||||| |.||  |.|...|| |.. |..| .| ||  .||.  |..|...|.|| |  ..   
pvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 486-763 3.2e-78 258.0 In-house 12-293 (298) alignment
Range on Protein: 486-763
Range on HMM: 12-293/298.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQ-EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKET
. .|. ..  .|..   ... |. .||.| . . . . .|. .... |||. || |.|..||||... .  .| |||| ....| . . .||||.| .||
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

CDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQASHVLD
  .|||||.|..  |||||||....      ||||.. .  ||.| |.  .. |  ....| .|| .|. .  |||.. |.|...||.| ||..|. |||
vedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvld

FMRAINSanDSKECG--PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYG
..| ..     ...|  ||.|.|||||||.|| ||.|  ||..| |. ||.  .|||||..|...||   |.||||.|||| .  .
llrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 486-773 1.9e-72 239.0 In-house 7-296 (305) alignment
Range on Protein: 486-773
Range on HMM: 7-296/305.0
TEFQEHVEQLNKNNQEMFKEIFESINSTspDYKCDatLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETC
 ........ ...... ... ..|. ..  . ..|  .  .| ...|||.|.|  .|. |. |.|.. ...|.||||.|..||   | ||..| | |.| 
ddlaayikearvysdkgleaqykslyee..eesid..vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE--VCYGDIVVRADRNIELPNYVIRGFKVFNKRDrGKKERTILQFHYITWPNKNVPAQASHVL
..|||...| |..||||||..|.       .|||      . .|...|    . . ..|..| .|. ....  |..||.||..  .||.. || .|. .|
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsll

DFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFS
.... .. .  . .  |..|||||||||||. ||.|||||.|| |. ||. ...| ||..| .|||.| |.||...|. | |  || | ... ..
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlr

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 486-759 2.3e-56 185.8 In-house 5-282 (290) alignment
Range on Protein: 486-759
Range on HMM: 5-282/290.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGVPH--SHYINANYIKGYYDDKLYIATQYPSKE
 .| |.|.. .....| |.. |....|.. ...    |  .  ....|||..|   |  |..|.. .| .    .|||| ||||| ..| ||||| | ..
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltss..nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgKKERTILQFHYITWPNKNVPAQASHVL
|  .||...|..|.  ||||||....      .|||. |   || . ..   . .| .|..| ..| ||.   ...... |..  .|...   .. . .|
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtil

DFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
  .. ..  .  .  ...|||||..|||... .|....... |.|  .|.  ..| .|.|. ..||   |. .|.. ||. 
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 486-761 7.7e-56 184.2 In-house 5-279 (287) alignment
Range on Protein: 486-761
Range on HMM: 5-279/287.0
TEFQEHVEQLNKNNQEMFKEIFESINS-TSPDYkcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQetpgVPHSHYINANYIKGYYDDKLYIATQYPSKET
 .| | |.. .....| ||. |  ... |  .   . |    . .. |||...|   |  ||.|.      |  |||| .|.|| ..| .|... |  .|
ekfgefvakghakgnegfknqftvleqvtqred..evthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

CDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKeRTILQFHYITWPNKN-VPAQASHVL
  |||.......  .||||..         ..|||... |..|.  ..   .    .|..| ..| ||   |.| ... |... .|...  |. ... .|
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdk.qqvkqyqitnWdstgkvtepqtill

DFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
 . . . .    .  ...|||||..|||... .| ...... | |  .|.  ..|  |.|. ..||   |. ||...||| . 
vieemyktqr.krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 486-578 2.8e-11 37.4 In-house 8-94 (95) alignment
Range on Protein: 486-578
Range on HMM: 8-94/95.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPdykCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETpgvPHSHYINANYIKGYYDDKLYIATQ
. |. || ..  | .. | . | ||. ||    .  |  . | .  |||| .|  .| |||||        | |||| .. ||   . |||.|
svfhshvlemhsnsdqefdnefksismtsg...apytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

0040438 (Phosphotyrosine protein) phosphatases II 487-781 1.4e-84 279.4 In-house 4-297 (317) alignment
Range on Protein: 487-781
Range on HMM: 4-297/317.0
EFQEHVEQLNKNNQEMFKEIFESINSTSPDykcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCD
.. .....|.|..  ...| || . | ..|   . .  . .  . |||..||  .||.||.|. ..|...| ||||.|..|..  . .||||.| ..|..
dlllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

NFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFM
.||||||||.. .|||||. ..      ..|||..... |||..|.    .||.....| ..| ..  .....||. .|||..||  .||   ...|||.
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfl

RAINSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIKSQE
.|...|.. .. |||.||||||||||||.||....||||. |..||.| .|| ||.|| ..|| . |..|.| |.|| . ...... . |. ....| ..
eavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli





subfamily_PTPRA_pd Subfamily PTPRA 487-780 4.8e-82 270.5 In-house 18-315 (330) alignment
Range on Protein: 487-780
Range on HMM: 18-315/330.0
EFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDatLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCD
...| ...   .. ..|.| |... ... .  ..  | ..| .. |||. .|  .|..||.|..  ||..| |||| .|.|| . . .||.| | .|| .
kleeeirirsaddnklfreefnalPagpiqatle..laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetve

NFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRG--KKERTILQFHYITWPNKNVPAQASHVLD
.||||.||||. ||||||.. .       .|||..  | ||.| |  . . .| .| .| | | .. |    ||.| . |||. .||.  ||...  .|.
dfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlk

FMRAINSANDSkECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDmsTLIDEFS--NHYI
....... |.  ..||.||||||||||||| |.||  ||..|.|..||. ..|| ||.||.|||| . |..|||...||  .|||  | .| .|  .|  
llkkvkklnqq.sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd..teldvsslekhlq

KSQ
| .
kly

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 487-785 1.7e-59 196.6 In-house 9-313 (325) alignment
Range on Protein: 487-785
Range on HMM: 9-313/325.0
EFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAqeyDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCD
.. ||||. . ..|. |   |. . |  .  |  |.. .   .  |||||.. |.|..||||.     |.| ||||.|.. . . . ..|.| |  .| .
nlvehvekkkaqdqdgfahefgllpsddgiakkvamkpe...nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

NFWRMV--WEqktVTIVMLTNVVDSF-----KYWPSD--DEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWP---NKNVPAQA
..||.|  |.    ..|...|..|       .||| .  . . .| . |.     |. .|| | ..|  |. .. . |.. ||.. .|.   ... ||  
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv..kqvkkGetrsvkqfqlqswddmGvqkrpatl

SHVLDFMRAINSA--NDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEF
  .|. . |..     ..|  .|..|||||||||||. |.|  ||...  | |||| | || ||..| .||.   |...||.|. | .. |.    .  |
isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf

SNHYIKSQEEATL
  .    ||   |
eaklsslqernpl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 487-758 1.2e-43 143.8 In-house 13-281 (290) alignment
Range on Protein: 487-758
Range on HMM: 13-281/290.0
EFQEHVE-QLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQEtpGVPhSHYINANYIKGYydDKLYIATQYPSKETC
 |..      .|| .|. || .| .    |    .  .. .. . .|||.||.   | |||.|..  | .   |. |||.||   .  .| || . |.| 
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gyd.GdyvhanyvkGl..kamfiltqGalkdtv

DNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDD--EVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKkERTILQFHYITWPNKNVPAQASHVL
 ..|||| ..|. .|||| ....       .|.|  .   . .|.| |    . .  . .|.      ..| || |  .  .. ..||.| |.  .  .|
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlall

DFMRAINsandsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
  .|..      |  ||||||||||.|||||..|....|. |     .|. ..|. ||. | . ||   |.. . ...|.
rtlrilr.....kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 488-758 3.6e-76 251.0 In-house 8-277 (288) alignment
Range on Protein: 488-758
Range on HMM: 8-277/288.0
FQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDN
  ..| . ...|.. |.| ..|. .   . . .|.   .  ...|||...| ..|..|| |.. . .. . ||||.||.|.  .| ||||| |  .| ..
pvakvakksarnrtgfseeynsLaalektksvtag..rlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE-VCYGDIVVRADRNIELPNYVIRGFKVFnkrdRGKKERTILQFHYITWPNKNVPAQASHVLDFM
||..|.|.|| ||||||..|.       .|||..|. . ||.. | .  . || ..| | . .     . |.|..| |..| .||...||...  .|...
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllell

RAINSANDSKeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
| .. ||...  ||..|||||||||||| |||| .......|. .|. |.|. ||.||...||.| |..|||...|.
rqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_CG7180_pd Subfamily CG7180 488-761 5.9e-58 190.8 In-house 5-291 (296) alignment
Range on Protein: 488-761
Range on HMM: 5-291/296.0
FQEHVEQLNKnNQEMFKEIFESINStSPDYKCDATLMAQEYDhtKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDN
| . |.. .|  .  .| ... ..      .| . | ..  .  |||  ..  .|..||||..  |  .|.|||| |. ..  .| || |. | ||| |.
flklvdkrrk.frveyklelkltpr.leigdCagglrkenre..knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvde

FWRMVWEQKTVTIVMLTNVVDSFK----YWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNK--------RDRGKKERTILQFHYITWPN-KNVPAQA
|||.|..... ..|.||.. |  |    ||| . .  ||.|.|   .. ...| .|| ||.  |        ..   ..|....|.. .|.  ..||  .
fWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlst

SHVLDFMRAINSAND----SKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
. .....| ...  .     .| |||||..| |..|.|  .|.|..||... |..||. . || ||..| |.|..  .. .||. .|| ..
nalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 489-760 1.3e-74 245.8 In-house 3-276 (281) alignment
Range on Protein: 489-760
Range on HMM: 3-276/281.0
QEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNF
..|..||..|... |.| .|....   |    |.   .. . .|||...| |.|.|||.....    .. |||||...|| ..| ||||| |  .....|
rkhlkqlsqndnaGfieeyeklaaigvdntatas..kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRMVWEQKTVTIVMLTNVVDS-----FKYWPSDD-EVCYGDIVVRADRNIELPNYVIRGFKVfnKRdRGKKERTILQFHYITWPNKNVPAQASHVLDFMR
|.||||||  .|||.|. ...      .||| |. |. |||..|.  .. | ..|. | ||.  .| .. ..|.. |..|..||.. |||.....|.| .
WqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..er.esgetreveqlaytaWPdhGvPattkellefrk

AINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSE-NRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDI
........|.  |.|.||||||||||| |||| .......| ...|.. .|. ||..|. ||| . |. |.| |||. .
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_PTPN9_pd Subfamily PTPN9 489-758 2e-62 205.9 In-house 4-288 (297) alignment
Range on Protein: 489-758
Range on HMM: 4-288/297.0
QEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMaqEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNF
.| |. .......  .. .. | ....  . .|. .    . .|||..|.  .|.|||||..... ..| |||||.. ||   | .|||| | |.|...|
eelvayvkekgkrGlskeyaeirnepveGtflaskl..ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMVWEQKTVTIVMLTNVVDS-----FKYWPS--DDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFM
|||||||....||| | ||.       .|||.  ..   .||. |.     |  .|..| ... | ..  ...|..  | ...||.  || .|. .||..
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdyGvPssaaslldvl

RAINSAND------------SKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
... ..                .  |.|||||||.||||| |.|||.|..|.... ||.   || ||.||. ..|   |..| | ||||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPN23_pd Subfamily PTPN23 490-759 1.2e-48 160.4 In-house 4-279 (288) alignment
Range on Protein: 490-759
Range on HMM: 4-279/288.0
EHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQetpgVPHSHYINANYIKGYYDD-KLYIATQYPSKETCDNF
|....   ...  ... |. ....      . .. . .   .|||..||  .||.||.|.      .  |||| ..|.       .|||| | ..|   |
eelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMVWEQKTVTIVMLTNVVDSFK-----YWPSD--DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQASHVLDFM
|.||.|||. .||||..  . .|     |||.|  . | .||. |   .. |....| | .|.  .. .  . ...   .. .||.  |||  ...|.|.
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad..avksvshlqltsWpelGvPasPetllqfl

RAINSA---NDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR-VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
 ...||   .  |   |.||||||||||||..  .  |...|. .|  .||  .|. ||.||  ||||  |. | |.|||| 
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 492-776 3.4e-67 221.6 In-house 15-295 (315) alignment
Range on Protein: 492-776
Range on HMM: 15-295/315.0
VEQLNKNNQEMFKEIFESINSTSPdYKCDatLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRM
| | . . .. ||. .|||      .  |     .  .. |||. .| |.|..|| |  .   |||.|.|||.|.||   . |||.| |  .. ..|||.
vaqkkastkngfkqdyesipggql.hpld..vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrl

VWEQKTVTIVMLTNVVDS-----FKYWPsDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKrdrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS
|.|..  .||||||.|.       |||| |..| || | |    .    .| .| . |  .    .. |...|.|| .||. .||. .  .....| .. 
vfeedigkivmltnlvegekrkaekywp.dkkviyGkitvtrkseevnteytvrtlsvvfg....dnirevvqlhytswpdmgvpkytiplmnlirtvkq

ANDSKEcGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHY
 ....  |..||||||||||||| |.||  |.|.. || .|.  ... .||.| .||| . |. |||.|.|| .| || |   | . ..|
hhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqry

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 494-758 6.4e-53 174.4 In-house 11-291 (301) alignment
Range on Protein: 494-758
Range on HMM: 11-291/301.0
QLNKNNqemFKEIFESINSTSPDyKCdaTLMAQEYDHTKNRFKDIGAFDHTRVVLQETPG--VPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRM
. ..|.   |.| .......... .|  |.  .| ... ||||.|  .|. |..|...|   . . .||||.||.|| . | .||.| | |.|  .|||.
akhsnk...feeqykelkegedk.sc..tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

VWEQKTVTIVMLTNVVDS-----FKYWPS--DDEVCYGDIVVRADRNIELPNYVIRGFKVF-----N--------KRDRGKKERTILQFHYITWPNKNVP
.|..|.|.|||.||  ..     ..|||.   ..  .| . |    .  .|..||| ..|      |        | .. |. ...||.. . ||.  | 
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvv

AQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 .   ||  .  .  .. . . ||||||||..|.|.|. ....|.||| |.|  ||. ...| .|...  .|. | |...||... .
reprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

0036941 (Phosphotyrosine protein) phosphatases II 495-771 9.7e-80 263.3 In-house 7-288 (297) alignment
Range on Protein: 495-771
Range on HMM: 7-288/297.0
LNKNNQEMFKEIFESINSTSPDYKCDATLMAqeYDHTKNRFKDIGAFDHTRVVLqetpGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWE
 ....  .... ||.. .  ........|       .|||.||| ..|||||.|    . ..| ||||.|..||. .. .||||.| ..|...|||||||
ekllflalllkefeellpllllgslsvallp..enleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

QKTVTIVMLTNVVD-----SFKYWPSD--DEVCYGDIVVRADRNIE--LPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAIN
|.. .|||||..|.      ..|||..  ....|||..|.  .  .  |..|..| ..| ..  .....||. .|||..||  .||  ....|||.....
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvr

SANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLK---SENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDE
....   . |||.|||||||||.||.||.|..|.||.    |..|||  .|| ||.|| ..|| | |..|.| |.|| . ....   ...
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

subfamily_PTPN14_pd Subfamily PTPN14 495-758 1.9e-55 183.0 In-house 16-294 (300) alignment
Range on Protein: 495-758
Range on HMM: 16-294/300.0
LNK--NNQEMFKEiFESINSTSPDYKCDATLMaqEYDHTKNRFKDIGAFDHTRVVLQETPGVpHSHYINANYIKGYY--DDKLYIATQYPSKETCDNFWR
|.|  .. ..|.| .| |   . | ..... .  . .  ||||||.  ....|| |. |    .. ||||  ||      .. ||..| | . |. .||.
lekkleegkvfte.yeripkkredallstakl..penaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWq

MVWEQKTVTIVMLTNV-----VDSFKYWPSD----DEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFM
|||||..  |||||.        ||||.|..    ..| .|   | .  . . . .. .|.|.  |    |.|||.. . |. ||...||   .. |...
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglkl..khlpskeertvwhlqytDWpdhgvPeDvkgflsyL

RAINSAN----DSK----ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
. ..|      ...    .  ||.||||||||||| .|  |. .. |. ....||. ... ||.||  .|| |.|. |.|.....
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 495-766 7.9e-49 161.0 In-house 3-272 (283) alignment
Range on Protein: 495-766
Range on HMM: 3-272/283.0
LNKNNQEMFKEIFESINStsPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGvphsHYINANYIK---GYYDDKLYIATQYPSKETCDNFWRM
|..||...|.| .. ..   || ..| .  . . ...|||...| . |  || |.  .     .|||| .|     | .|| ||..| | ..|  .||.|
lrvnnnklfrevlkrlsv..pdldadia..sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkm

VWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS
|...| ..|||||.. .       .|||..  . ||.  |   ..     ..|. . . ..    |..  .  . .| | . .  |    .. | . |  
vfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.ssakstlllahyqvidWleygeqaiinslvkfnkvisl

ANDSKeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMS
 ..||  ||.|||||.|.|||.. ||.  .......|  ||.  .||..|.||  .||.| |. .....|||. . ||  
qtesk.kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtq

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 495-758 3.1e-36 119.9 In-house 11-275 (307) alignment
Range on Protein: 495-758
Range on HMM: 11-275/307.0
LNKNNQEMFKEiFESINSTSPDykcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQeTPGVpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWE
|.|  |..  | |. .   .|.     |  | . .  |||..|. . |..|.|.. ..|.  | || |||.    . | .|..| | ..|  .|| |. .
ldkgvqalvde.frvlakktpe...gvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

QKTVTIVMLTNVVDS-----FKYWPSDDEvcYGDIVVRADRNIELPNYVIRGFK-------VFN-KRDRGKKERTILQFHYITWPNKNVPAQASHVLDFM
.|  ...|| .|..       .||| ..      . . | . | . |  .. .        | . | | ..| ||| .. .  ||.. ||      ....
ekvesvimlckvielakikceqywpleeg..qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll

RAINSandskECGPVVVHCSAGVGRTGTIIALDIALEQ-LKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 |..      .  ||||||||||||.|||.|. .  .. .. .|  |.. .|. ||.||   .|.  |.....  .||
eavry.....dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

0047943 (Phosphotyrosine protein) phosphatases II 496-758 8.7e-80 263.4 In-house 7-270 (273) alignment
Range on Protein: 496-758
Range on HMM: 7-270/273.0
NKNNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLqetpGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQ
....  ...| || . |. |.... ..|. .   ..|||.||| ..||.||.|    | ..|.||||.|..||.  . .||||.| ..|...||||||||
kllgltllleefelllslkplltysvallpe..nkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KTVTIVMLTNVVD-----SFKYWPSDD---EVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQASHVLDFMRAINSA
.. .|||||..|.      ..|||..    .. ||.. |.  .  . ..|..| ... |. .   ..||. .||| .||. .||.. ...|.|......|
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtg..esrtvthfhytgwpdhgvppslesllefielvrka

NDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
. .  . ||||||||||||||||.||||..|.||. |..||.. .|| ||.||  ||| ..|..|.|.|.||
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_PTPN12_pd Subfamily PTPN12 496-758 8e-69 226.7 In-house 3-275 (290) alignment
Range on Protein: 496-758
Range on HMM: 3-275/290.0
NKNNQEMFKEIFESINSTSPDYKCDATL----MAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRM
.|...| |.. |... ..|  || ...       .|.. .|||.|||  .|..||.|... ....| |||||.||| .... |||.| |  .| |.||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

VWEQKTVTIVMLTNVVDSF-----KYWPSD--DEVCYGDIVVRADRNIELP-NYVIRGFKVFNKrdrgKKERTILQFHYITWPNKNVPAQASHVLDFMRA
.||...  .||. ..|.       .|||.   .|. .|.. |  ...  .  ...|| .|| ..    |..|.. ||||  ||...||..|...|.....
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssakslleliel

INSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR---VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
... .. .|  |.||||||||||||||||.|.. |.||.|.    .|.  .|  ||.||. .||   |....|.||.|
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 496-776 1e-63 210.2 In-house 12-292 (515) alignment
Range on Protein: 496-776
Range on HMM: 12-292/515.0
NKNNQE-MFKEIFESINstSPDYKcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWE
|||..  .| | |  .    |.     |.  .| ...|||.|.|  .| .|| |.     ||| |.|| ||...  || |||.| | | . |.|||.|..
nknrhttlfseefhdlp..gpniy.pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlq

QKTVTIVMLTNVVD--SF---KYWPS--DDEVCYGDIVVRADRNIELPNYVIRGFKVFnkrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSA
... ||.|.|.  .       ||||    | | .| | |         . ..| ..|     .|.. ||. |||.  ||.| || ..| .| ..... . 
envttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl....kgddsrtvtqfhfteWPdkGvpkhtssllklikevkad

NDSKEcGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHY
..  .  |...|||||||||| .|..|  . . |  . ||.  .|...||.| ..||   |. |||.|||||. . .    .  |..| 
hgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhl

subfamily_PTPRN_pd Subfamily PTPRN 497-760 1.4e-53 176.5 In-house 26-292 (297) alignment
Range on Protein: 497-760
Range on HMM: 26-292/297.0
KNNQEMFKEiFESINSTSPDYKCDaTLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYY-DDKLYIATQYPSKETCDNFWRMVWEQ
||.. . || .|.. .   . ..  ..  .|   .||| |.. ..||.|| |.|.    .|.||||  |         ||||| |  .|  .||.|||||
knkdrleke.wealcayeaepstk.evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

KTVTIVMLTNVVD-----SFKYWPSDDEVCYGDIVVR-ADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSAND
 .| ||.||.. .       .||| . .  |.   |.     |   .|..| | . | .   .. ||. |||...||...|||.|  .|.| | .| .  
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq..tsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

SKECgPVVVHCSAGVGRTGTIIALDIALEQL-KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDI
 . | |.|||||.|.||||. |..|. |..| |  ...||   .. ||.||...|.   || |.. || |..
Grsc.pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_PTPN1_pd Subfamily PTPN1 498-762 8e-56 183.9 In-house 3-273 (290) alignment
Range on Protein: 498-762
Range on HMM: 3-273/290.0
NNQEMFKEIFESINSTSPDYKCDATLMaqEYDHTKNRFKDIGAFDHTRVVLQETPGvphsHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKT
......|||.. |.  . |... .. .  . ....||..|.  .||.|..|...      .||||. ..    .. || || |  .|.| ||.||||||.
dkkrlykeiyldirkeasdfptreakl..penrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqks

VTIVMLTNVVD-----SFKYWPSDDE---VCYGDI--VVRADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAI-NS
 ..||| .||.      ..|||...|   . . |.   |.  .. .  .|..| ... |..   .. |.||.|||.|||.  ||   .  |.|.  . .|
kavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk..tqetreilhfhyttwpdfgvpespaaflkflfkvres

ANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSEN---RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVY
   |.. ||.|.|||||.||.||.. .|  | ... ..    |||.  .  ||..|. ..|   |. | | |.|| .  
GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 498-758 4.4e-37 122.5 In-house 3-257 (267) alignment
Range on Protein: 498-758
Range on HMM: 3-257/267.0
NNQEMFKEIFESINSTSPDYKCDATLMAQEYdHTKNRFKDIGAFDHTRVVLQETPGVphshYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKT
...  ... || |.  |..    .. .|..  . .||. |   .|.|||.|...       |||| |..||.  . .|.|| | | |  .|. .. .|| 
deeceiekefelikkisdtsstisqsiaekn.qernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkv

VTIVMLTNVV-DS-FKYWPSD--DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGkkeRTILQFHYITWpnkNVPAQASHVLDFMRAINSANDSKEC
 .||.||.|  |   ..||    .   | |..|    . |  .| |  ...  | .     . .  ..|  |   |. ..    |  . .| . |. .. 
pvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa...hnvtlyyykkw...nintnnkpylkplfgilaknqleng

-GPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
  |.||.||.||||.|| . .|  ||..| |. .||   .. .|.||  .|. . ....|.. . |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 498-568 4.3e-06 20.5 In-house 10-77 (244) alignment
Range on Protein: 498-568
Range on HMM: 10-77/244.0
NNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPgVPHSHYINANYIKGY
...|. || | ...  . ..    ....   . ||||. .|  ||.|||.|  .     | |||||||.| 
qdeevakeefvglsdhtreflqtnavlsa..natknryinilpfdetrvilsssk.kegsdyinanyiqgs

subfamily_PTPN13_pd Subfamily PTPN13 499-758 1.4e-57 190.1 In-house 9-267 (273) alignment
Range on Protein: 499-758
Range on HMM: 9-267/273.0
NQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGvphshYINANYIKGYYDDK--LYIATQYPSKETCDNFWRMVWEQK
.|.. .| |. ..   |  .|. .  ..  ...|||....  .|.||| |..  |     ||||..||   ...   |||.| |  ||...||.||||||
dqqqPaeefkelrelkpldtcevgkkke..nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

TVTIVMLTNVVDS-----FKYWPSDDE---VCYGDIVVRADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSAN
.  |.|.|. ...      .|||.  .   . .. . |.  .  .| ..|.| ..| ...   .. | . ......||. .||..| ..| |.. ... .
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

DskECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.  . ||.|||||||.||.||.|..|..|. .. .. .|.. ||. ||.||  .||   |..|.|.|.||
t..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 499-757 7.8e-21 68.8 In-house 24-282 (302) alignment
Range on Protein: 499-757
Range on HMM: 24-282/302.0
NQEMFKEIFESINSTSPDYK-CDatlmAQEYDHTKNRFKDIGAFDHTRVVLQETPgvphSHYINANYIKGYYDDKLYIATQYPSKETC---DNFWRMVWE
..   |. |..|...  |   |     |   .  ||. .|. . |...| |...|     .|.||  ..     .  | .| | ...    ..|||||..
dtaevkkefkkidtmkvdlekCk....afkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

QKTVTIVMLTNVVDS----FKYWP--SDDEVCYGDIVVRADRnIELPNYVIRGFKVfNKRDRGKKERTILQFHY-ITWPNKNVPAQASHVLDFMRAInSA
.| |..|.|    .      ...|  |.| . ||.. |   . .|  .     . .      |  .  . .      |..|.|| . ...   .  .  |
ekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrk.Vekaeeektryvi.EvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fa

NDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
...|   ..|.    |.|| |....| .|.|.|.... . |. ||| .|.||...|. |.|.|..| |.|
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 500-775 6.9e-54 177.7 In-house 19-251 (392) alignment
Range on Protein: 500-775
Range on HMM: 19-251/392.0
QEMFKEIFESInsTSPDYKcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVT
  .| | |  .   .||   . |   .| .  |||.|.|  .| .||.|.    .|.| |.|| ||...  .| |||.| |   . |.|||||..... |
salffeefhdl..pgpdiy.pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtt

IVMLTNVVDSFkywpsddevcygdivvradrnielpnyvirgfkvfnkrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAInSANDSKECGPVVVH
|.|.|.. .                                         .|.. ||. |||.  ||.|.|| ..| .| |.. . .|.  .   |...|
iamvtklkegd.......................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliih

CSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNH
||||||||| .|..|  . . |    ||.  .|  .|..|  |||   |. ||| |||||... .    .  |..|
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdh

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 500-758 4.1e-36 119.1 In-house 10-267 (281) alignment
Range on Protein: 500-758
Range on HMM: 10-267/281.0
QEMFKEIFESINSTSPDYKCdaTLMAQEYDHTKNRFKDIGAFDHTRVVLQE-TPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTV
 . ||. |  .    |   |  | . |  .  |||. .| ..| .|| |.   |    . || ||||.  .  . || || | |||  .||||.|...| 
lddfkqefsnlpgdppsdlc..tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentt

TIVMLTNVVD-----SFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKvFNKRDRGkKERTILQFHYITWPNKNVPAQASHVLDFMRAINSandskEC
.|||| ....       .|.| .  .|     .  . .    |  .   . .|    | . | | .. .  ||. .||  .  .|  .| | .       
aivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.lnlsyeg.etrlithwlwkewpdwqvpessevmlkilrkira.....rs

GPVVVHCSAGVGRTGTIIALDIALEQLKSENR-VDIEGIVKVLRQ-QRTQMVQELCQFVFIYNAVLE
 | |.||||||||.||..|..|||. ..|     ||. ||  ||   |.  || | |...|.. .|.
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 500-763 4.3e-23 76.5 In-house 19-278 (312) alignment
Range on Protein: 500-763
Range on HMM: 19-278/312.0
QEMFKEiFESINSTSPDYKCDATLMAQEYdhtkNRFKDIGAFDHTRVVLQETpgvpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVT
|.. || . ..    .| .| | |  ..     ||. .|  .|  |  |          || ||..|     . ...|| | ..|| .||...    ...
qqltke.ykavgnivsdsectaflkfkdl....nrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgsts

IVMLTNVVDSFKYWP---SDDEVCYG---DIVVRADR--NIELP-----NYVIRGFKVFNKRDrGkKERTILQFHYITWPNKNVPAQASHVLDFMRAINs
|..|. .|.           | | .    |  | ..   .||.      .   | .||  |   | .|  . .. . .||.. .|      | .. |.. 
iillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkat.g.qesklnhyqwaswpdhgmpdscdtalrllsavk.

andsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIvYG
    |.  ||. |||||||||||.. ..  .  |.   . ..  .  .||..|.. |. . |.|.   .||| . | 
....kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl.ys

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 501-776 6.7e-63 207.4 In-house 19-293 (315) alignment
Range on Protein: 501-776
Range on HMM: 19-293/315.0
EMFKEIFESInstsPDYKCDATLM-AQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVT
 .| | |  .    || .   .    .. ...|||.|.|  .|..||.|.     |.| |||| |||.. ||| |||.| | | . |.|||||...|. |
alfseefhdl....pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMLTNVVDSFK-----YWPS--DDEVCYGDIVVRADRNIELPNYVIRGFkVFnkRdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKE
|||.|.  .. |     |||    | | .| | |         . |.| . |   | .... ||. ||..  ||.| |. |.| .| ..... . |..||
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt..r.kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkke

cGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHY
  ...||||||||||| .|..|  ..|.| .. ||.  .|| ||..| ..||   .. |||.|||||. . .   |.  |..| 
.fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 502-752 1.4e-25 84.6 In-house 24-273 (301) alignment
Range on Protein: 502-752
Range on HMM: 24-273/301.0
MFKEIFESINSTSPDyKCDATLMAQEYDHTKNRFKDIGAFDHTRV-VLQETPGVPhshyINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTI
...  .|..| |. | | . |       . |.|.. .    .| | |...   ||    | ||.|.   . . .|||| | |.|...|| |.   .  .|
fynttienvnvttid.kdhitesyaylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydveki

VMLTNVVDSF-----KYWPSDD----EVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINsanDSK
|||.. |.       .| |..     ..   .| ..    |   . . | ..| .  ..  . ||.. . | .|....||    .. |.|  .    .|.
vmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk.fatrtvthyqysewtdrgvPkshaelfdlmelvk...kse

EcgPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFI
.  |.|||||||.||. . |. ..   ..........   .| ||..| . ||   |. ..
k..PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

DSPc_SM00195 503-758 1.5e-77 255.8 In-house 2-260 (263) alignment
Range on Protein: 503-758
Range on HMM: 2-260/263.0
FKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVM
.|| ||....  .. ... .  ...  ..|||.|.|  .||||| |..... ..| |||||||||.  .| |||||.| ..|.. |||||||.|. .|||
lkeefekleestspkettea..ekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTNVVD-----SFKYWPSD--DEVCYGDIVVRADRNIELP-NYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKeCG
||. ..       .|||..  ..  .|.| |   .... . ....| ... .. .  ...|.. |..| .||...|| ....||...||... ....  |
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|.|||||||||||||....||.|..|..|..|||. ||| ||.|| .|||.| |. |||.|.||
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 503-758 1.5e-77 255.8 In-house 2-260 (263) alignment
Range on Protein: 503-758
Range on HMM: 2-260/263.0
FKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVM
.|| ||....  .. ... .  ...  ..|||.|.|  .||||| |..... ..| |||||||||.  .| |||||.| ..|.. |||||||.|. .|||
lkeefekleestspkettea..ekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTNVVD-----SFKYWPSD--DEVCYGDIVVRADRNIELP-NYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKeCG
||. ..       .|||..  ..  .|.| |   .... . ....| ... .. .  ...|.. |..| .||...|| ....||...||... ....  |
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|.|||||||||||||....||.|..|..|..|||. ||| ||.|| .|||.| |. |||.|.||
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0046845 (Phosphotyrosine protein) phosphatases II 504-762 1.4e-83 275.8 In-house 3-276 (284) alignment
Range on Protein: 504-762
Range on HMM: 3-276/284.0
KEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGV-PHSHYINANYIKGY-----YDDKLYIATQYPSKETCDNFWRMVWEQKT
.| || ..|  ... .. .  . .  ..|||.||| ..||.||.|. ..|  ..|.||||.|..||     |  | .||||.| ..|...||||||||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

VTIVMLTNVVD-----SFKYWPSDD-EVCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDS-
 .|||||. |.      ..|||...  . |||. |.  .  . ..|..| ... |. . ....||. .|||..||. .||......|.|.|........ 
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

KECGPVVVHCSAGVGRTGTIIALDIALEQLKSEN---RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVY
.  ||.|||||||||||||.||||..||||. |.   .||....|| ||.|| .||| | |..|.|.|.|| . .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_PTPN3_pd Subfamily PTPN3 506-758 1.4e-62 206.2 In-house 20-273 (280) alignment
Range on Protein: 506-758
Range on HMM: 20-273/280.0
IFESINSTSPDYKCDATLMAQEydHTKNRFKDIGAFDHTRVVLQETPgvphSHYINANYIKGYYDD----KLYIATQYPSKETCDNFWRMVWEQKTVTIV
 || .    |. ...|. ....   .|||..|| ..|.||| |.|..    . ||||||..   .     . ||||| | ..|. .||.||||||. .||
qfeqlyrkkpglaisaarkpen..lsknryrdilpydatrvklkese....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTNVVDS-----FKYWPSD-DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKEcGP
|||..|..      .|||.  ||. ||.. |.  .. |  .||.| . . .|.   |.||.|||. |. ||...|| .....|.|.. ....  .||  |
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket..keerkilqlqylaWpdhgvPddsadflefvervrklrsgke.eP

VVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
||||||||.|||| .|.|..||  . ... | .  ||. .|.||. .||   |. |. .|.|.
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 507-757 6.6e-53 174.3 In-house 16-274 (287) alignment
Range on Protein: 507-757
Range on HMM: 16-274/287.0
FESI------------------NstspdykcdatlmaqeydHTKNRFKDIGAFDHTRVVLQETPGVpHSHYINANYIKGYYDDKLYIATQYPSKETCDNF
.. .                  .                    |||. |.  .|.|||.| ...    | ||||||. .| ||. .||.| |   |  .|
vdalkedsesstatfkaaeelaa..................vkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdf

WRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEV--CYGDIVVRADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQ----ASHV
||.|.|... .....|  |.      .||||  .      |  ||  |..|  |.| .| ... .    ... | . |.....||.| ..      .  |
wravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle..trearvvkqldllswPdkvlaPtavglirfv

LDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
||  . |. | |..| ||.|||...|.||.|...|. . ...|..  |||.  .|  ||..|. .||   |. ..|.|. 
ldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 508-608 2.6e-18 60.8 In-house 29-124 (305) alignment
Range on Protein: 508-608
Range on HMM: 29-124/305.0
ESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLqeTPGVPHsHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVV
 ...      |  |   ||  .. |||.||.| .|. || |   .  || .|| |||.    . | .| || | ..|| .|| | ...|  .| || |..
vamkrfndfekmkafkeaq..eagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnll

D
.
e

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 513-758 1.7e-32 107.3 In-house 37-287 (305) alignment
Range on Protein: 513-758
Range on HMM: 37-287/305.0
TSPDYKCDATLM--AQEYDHTKNRFKDIGAFDHTRVVLQETPgvpHSHYINANYIKG-YYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS
| ||    |     . . . ||||..|. . |.. | |.. .    |.|| |||.      .| .|..| |  .| |.|| || ..|   |||| . |. 
trpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvel

F-----KYWPSD---DEVCYGDIVVRA-DRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANdskecGPVVVHC
      .|||          . |||     .  .         ..|    |... .. ....  ||.. ||      |... ||  ..      |.||||
gklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhc

SAGVGRTGTIIALDIALEQLKSENRV-DIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|||.||||||.|..  ||..  ....  .  .|| ||.||.  .|.  |..||.  .|.
sagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 515-766 7.8e-58 190.9 In-house 36-290 (297) alignment
Range on Protein: 515-766
Range on HMM: 36-290/297.0
PDY-KCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDdkLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS----
|      .|   .  .  |.|.|.|  .|  || |. .   | | |.|| ..||.     .|.|| | |.| ..||.||..... |||||..  ..    
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkc

FKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWPNKNVPA--QASHVLDFMRAINSANDSKECGPVVVHCSAGVGRT
 .||. .  . .||..|      |   .. | ..|  .... |..| . |.... ||.|.|.   .|| .|...  ..   .... ||..|||.||||||
aryWsdkgvttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrt

GTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMS
| ....|  . . | |. ||| |.|| |||.| ..||   |. |.|.|||| ..  |. 
gvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 518-780 1.1e-69 230.2 In-house 50-311 (319) alignment
Range on Protein: 518-780
Range on HMM: 50-311/319.0
KCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVdSFKYWPSDD
 .| |    . .  |||. .| |||...| |. . |.  | |||| ...||   . |||.| | ..| ..||||.||... |||.||.     .||| . 
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkdk.csqywplki

EVCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS-ANDSKECGPVVVHCSAGVGRTGTIIALDIA
.. ..   |. |   |  .||.| ... ..  . |  | | |||.  ||.. || ..| .. ... ..   .  ..  ..||||||||||||. |.||. 
vikeerfkvkvdsveetaeyvvrdielsed.gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIKSQ
|...| |..||.  .|. ||||| ..||.| |. ||| |.||. ..|     . .|  .. .  
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 518-606 6.9e-10 32.8 In-house 37-141 (349) alignment
Range on Protein: 518-606
Range on HMM: 37-141/349.0
KCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPG----VPHSH----------YINANYIK--GYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIV
  |  |       .|||.|||  ..|.||.|....     . .|.          ||||||.|   .  .| ||||| |.  | |.|....  ..   ..
iddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MLTNV
 |.. 
sLndd

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 519-614 2.6e-15 51.0 In-house 37-151 (350) alignment
Range on Protein: 519-614
Range on HMM: 37-151/350.0
CDATLMAQEYDHTKNRFKDIGAFDHTRVVLQET----PGVPHSH----YINANYIKGY-----YDDKL-YIATQYPSKETCDNFWRMVWEQKTVTIVMLT
 |  |       .|||.|.|  ..|.|| |...     .. ||.    ||||||.|        . .  ||||| | ..| |.|.... . |   |..||
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslt

NVVDS-----FKYWP
. |.       .||.
sdvelnlekcyrYWq

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 520-755 2e-27 90.6 In-house 41-285 (310) alignment
Range on Protein: 520-755
Range on HMM: 41-285/310.0
DATLMAQEY--DHTKNRFKDIGAFDHTRVVLQETpGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKY
|..|  . |     |||. |.   | .|| |.      .  || |||.|  |  . .| .| | . |  .||||...... .|..| .|..        |
dssltyeaykkymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPSDD-EVCYGDIVVR----ADRNIELPNYVIRGFKVFNKRDR---GKKERTILQFHYITWPNKNVPAQASHVLDfMRAINSAndskECGPVVVHCSAGV
|||      || | |     .  ..|. |  .         |      ||  .   ..  ||.. || .  | .   | .         ||.|||||||.
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv....rhgpcvvhcsagk

GRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNA
.|.....||......|.  ..||.| ..  |...|.. .|   |...|   
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 520-761 9.5e-27 88.7 In-house 26-271 (285) alignment
Range on Protein: 520-761
Range on HMM: 26-271/285.0
DATLMAQEYDHTKNRFKDIGAFDHTRVVLQETpgvpHSHYINANYIKGY-YDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYW
..|  | | .   ||. |. . . |||||..        || |....    |.  ||.|| |  ||  .||.|....|   ..||  ...        |.
nctytayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PSD--DEVCYGD--IVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDsKEcGPVVVHCSAGVGRTGT
|    . | .|   | .   ..  .   ..  . | |  |   .   . . .   ||..  | .|  .... . ..  |  ||  |..|||||||||| |
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.ke.kpicvhcsagvgrtat

IIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
.. .| |  ..  .  ...  ||. .|  | | ||   ||.|.|  ..| ..
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 521-603 1.6e-11 38.3 In-house 29-116 (347) alignment
Range on Protein: 521-603
Range on HMM: 29-116/347.0
ATLMAQEYDHTKNRFKDIGAFDHTRVVLQ-----ETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVML
 |    | . .||| ||    | |||||       ..  .   |||| .||    .| || ||||  .|  .||.||   |   .| .
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_ptpA1_pd Subfamily ptpA1 522-720 2.3e-27 90.8 In-house 40-256 (418) alignment
Range on Protein: 522-720
Range on HMM: 40-256/418.0
TLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDdKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNV-----VDSFKYWPSD
.   .... .|||. .|   .|||| |..      | ||||||| | |  | .|.|| |  .|  .|||||||..   ||||.       .   .||| .
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

----DEVCYGDI-VVRADRNIELPNYVI---RGFKVFNKRDR-GKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSAN-----DSKECGPVVVHCSA
    .   ||.   |    ..|| . .    |     | |     . | | |..|  ||..|.| ..  . .....|   .      |    |..|||||
iggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRTGTIIALDIALEQL
|||||||. .  | ...|
gvgrtgtfctavimmkkl

subfamily_egg_pd Subfamily egg 523-765 5.2e-26 86.0 In-house 34-277 (307) alignment
Range on Protein: 523-765
Range on HMM: 34-277/307.0
LMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFK---YWPSD--D
  |..   .| | | .   | .|| |.   |     .| ||..||      .| .| | |.| |.|||||....   |||||  ..| .   |||    |
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesd

EVCY--GDIVVRADRNIE--LPNYVIRGFKVFNKRdrgkKERTILQFHyiTWPNKNVpAQASHVLDFMRAINSAndSKecgPVVVHCSAGVGRTGTIIAL
 . .  | . . . .  .   | . .  .|.        .|   |.     .  .|. ..    |  .| .  .  ||   ||||..  || ...|..|.
slvtvpGslrienlkvdskadplfrvtklklvGgd....deerflehw..qgdvnns.sdvysplrvlrklrnl..sk...pvvvqdilGvskaatlvai

DIALEQLKS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL---EDIVyGDM
.||| .|      .  .   |. ||..|   |.   ...|.|  ||    |.. |  
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi.gsa

0040439 (Phosphotyrosine protein) phosphatases II 526-758 1.8e-74 245.8 In-house 8-244 (249) alignment
Range on Protein: 526-758
Range on HMM: 8-244/249.0
QEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVC
 . .. |||..|| ..||.||.|. .||...| ||||.||.|||  . .||||.| .||...||||.||..  .|||||. |       ..|||..... 
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

YGDIVVRADRNIELPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQ
|||..|.  . .....|..| ... |.    ...||.|...|. ||  .||   ...|||..|...|...  . |||.||||||||||||.||....|||
ygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

LKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|. |..||.| .|| ||.|| ..|| . |..|.|.|.||
lekelgvdleeavkllrsqRpgavqnpeqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 526-758 6.7e-67 220.9 In-house 7-240 (243) alignment
Range on Protein: 526-758
Range on HMM: 7-240/243.0
QEYDHTKNRFKDIGAFDHTRVVLqetpgvPHSHYINANYIKGYydDKlYIATQYPSKETCDN----FWRMVWEQKTVTIVMLTNVV-----DSFKYWPsd
 .....|||..|| ..||.||.|      . | |||||.|...  .. .||||.| .||...    ||||.||... .|||||. |     . ..|||  
lpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

DEVCYGDIVVRADRNIELPNYVIRGFKVFNkRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDS-------KECGPVVVHCSAGVGRTGT
.||.|||..|.     .|..|..| ... |  | .. .|.. ..||. ||  .||   ...|||......  ..       .. |||.||||||||||||
gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

IIALDIALEQLksenRVDIEGIVKVLRQQRTQ-MVQELCQFVFIYNAVLE
.||... |..|    .||.| .|| ||.|| . .|| . |..|.| |.||
liaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 527-781 2.2e-69 229.1 In-house 23-276 (284) alignment
Range on Protein: 527-781
Range on HMM: 23-276/284.0
EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVdSFKYWPSDDEVCYGDIVV
. .  |||. .| |||...| |. . |.  | |||| .|.||   . ||||| | ..| ..||||.||... |||.||.     .||| . .. ..   |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdk.csqywplkivikeerfkv

RADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS-ANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR
. |   |  .||.| ... ..  . |. |.| |||.  ||.. || ..|... ... ..   .  ..  ..||||||||||||. |.||. |...| |..
kvdsveeseeyvvrdielsed.gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekq

VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIKSQE
||.  .|. |||||...||.|.|. ||| |.||. ..|     . .|  .. .  .
vdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 527-758 6.1e-58 190.9 In-house 18-262 (270) alignment
Range on Protein: 527-758
Range on HMM: 18-262/270.0
EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEV-
  ... ||..||    .|||.|.|    ... ||||||..|. . .| |||.. | . |  .||||.||.|. .|||.|....       .|||.. .  
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

---CYGDIVVRADRNIELPNYVIRGFKVFnkrDRGKKERTIlQFHYITWPNKNVPAQAS------HVLDFMRAINSAN-DSKECGPVVVHCSAGVGRTGT
    .|.| |.|  .     |...  ..    ..|...| .  |.| |||.. || ..       ..|  .||.   . . .. .|..||||||||||||
vkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

IIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.||||||.. |.....||.  |.. ||..|...||   |. |.|.||.|
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 527-568 2.9e-09 30.8 In-house 45-86 (440) alignment
Range on Protein: 527-568
Range on HMM: 45-86/440.0
EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGY
  .. |||...| |.||.||.|.|  |||.|.|||| ||.| 
pnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

0042113 (Phosphotyrosine protein) phosphatases II 528-758 8.4e-74 243.3 In-house 8-241 (245) alignment
Range on Protein: 528-758
Range on HMM: 8-241/245.0
YDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEVCYG
 ...|||..|| ..|||||.|....| ..| ||||.|..||.  . .||||.|..||...||||.||..  ||||||. ..     ...|||..... ||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

DIVVRADRNIELPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS
|..|.  .   |..|..| ..| |.  . ...|.....||. ||  .||   ...|||......|  ... |||.||||||||||||.||....||||..
dftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
| .|..| .|| ||.|| ..|| . |..|.| |.||
elgvsleeavkelrsqRpgavqtpsqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 528-758 2e-71 235.9 In-house 32-270 (278) alignment
Range on Protein: 528-758
Range on HMM: 32-270/278.0
YDHTKNRFKDIGAFDHTRVVlqetpgvphsHYINANYIKGYydDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYG
 .  |||.||| ..||.||.           ||||.||.||  .| .||||.| ..|...||||.||... .|||||..|.      ..|||... . ||
gnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

DIVVRADRNIELPNYVIRGFKVFNK--RDRGKKERTILQFHYITWPNKNVPAQA--SHVLDFMRAINSAND------------SKECGPVVVHCSAGVGR
|..|.     .|..|..| ..| |   .. . ..|.. ..||..||  .|| .   ...|.... |..|..              . |||.|||||||||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

TGTIIALDIALEQLksENRVDIEGIVKVLRQQRTQ-MVQELCQFVFIYNAVLE
|||..|... ||.|  |..||.. .|| ||.|| . .|| | |..|.| ..||
tGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

0049772 (Phosphotyrosine protein) phosphatases II 528-758 1.4e-43 145.2 In-house 45-278 (314) alignment
Range on Protein: 528-758
Range on HMM: 45-278/314.0
YDHTKNRFKDIGAFDhTRVVLqETPGVPHSHYINANYIKGYyddKLYIATQYPSKETCDNF----------WRMV--WEQKTVTIVM-------------
  ..|||..||  .| .||.|  . .|  | ||||.|..|.   . .||||.|...|...|          ||||  ..... .|||             
lnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LTNVVDSFKYWPSDDEVCYGdivvradrnielpnY-------VirgfkvfnkrdrgkkERTILQFHYITWPNKNVPaQASHVLDFMRAINSA
        |...   . ...  |   .                       .               ||.......| .|  ..|   .....|...|..|
daAlgKtpllildgngneptaadlellk..............eelydpelf...............erlgikylripvpDgsap.lledfdeflefieea

ndsKECGPVVVHCSAGVGRTGTIIALDIALEQLksenRVDIEGIVKVLRQQRT-----QMVQELCQFVFIYNAVLE
   .. |||.|||.||.||||| ..... . .|    .|..| ... .|..|.      ... |.|..||..|.||
...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 528-766 4.8e-28 93.0 In-house 42-277 (288) alignment
Range on Protein: 528-766
Range on HMM: 42-277/288.0
YDHTKNRFKDIGAFDHTRVVLQETPgvphSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSD--DEVC
 . |..|....   | ||| |.. |      ||.|| .     ..  | .| | . | ...|.|. |.    ||||.....     | .|.||   ... 
anptrdryenlprcditrvklsddp....dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGDIVVRADRNIELPNYVIRGFKVFNKRDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIALDIALEQL
.| .     .. .  . ...   . ...  |...  . . |.  |... || .    | ..  .      .   |.|||.|||||||||.|   ||||.|
igrlctvvkkkradidklvkvsllriske.geekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialesl

KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMS
.... . |. ... ||..| . .|   |.....  |||....    
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkyk

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 528-679 7.2e-10 32.0 In-house 26-163 (169) alignment
Range on Protein: 528-679
Range on HMM: 26-163/169.0
YDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINAnyikgyyddklyiatqypsketcdnfwRMVWEQKTVTIVMLTNVVDSFKYWPSDDE------VC-
 ..||||     |  |||| ||       | ||||                           ||.||  .  ||.| .  |   .||  ..      |  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

---YGD-IVVRADRNIELPNYVIRGFK---VFNKRDRGKKERtILQFHYITWPNKNVPAQASHVLD
   | | . ||.|.   . . |   |.   |. . |.   |. .  .|| |||.. ||    ||  
gewytdslyvrtdkvhantsgveglfevsmvihsydddvtek.lsllhystwpqngvpqspvhvgh

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 528-679 8.1e-09 28.5 In-house 25-162 (169) alignment
Range on Protein: 528-679
Range on HMM: 25-162/169.0
YDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINAnyikgyyddklyiatqypsketcdnfwRMVWEQKTVTIVMLTNVVDSFKYWPSDDE------VC-
 . ||||     |  |||| ||       | ||||                           ||.||  .  ||.| .  |   .||  ..      |  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

---YGD-IVVRADRNIELPNYVIRGFKVFNKRDRGKKERT--ILQFHYITWPNKNVPAQASHVLD
   | | . ||.|.     . |   |.|    .. ... |  .  .|| |||.. ||    ||  
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 529-761 6.2e-74 243.4 In-house 9-243 (250) alignment
Range on Protein: 529-761
Range on HMM: 9-243/250.0
DHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS----FKYWPSDDEVCYGDI
.. |||. || |.|..||||... |  .| |||| ...|| . |..|||| | ..|  .|||||.|.|. |||||||...|     .||| .    |||.
nkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdv

VVRADRNIELPNYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSEN
 |    . |  .|..| .|. ...   ..||.. |.|...||.| ||..|  ||.... ... ..  . .||.|.|||||||.|. ||.|  ||.|| |.
tvsllskeefadytkrklklskakk..aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
 ||.  ..||||..| ..|. | |.||.|...|. ..
vvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 529-757 2.4e-61 202.2 In-house 28-265 (274) alignment
Range on Protein: 529-757
Range on HMM: 28-265/274.0
DHTKNRFKDIGAFDHTRVVL-QETPGVPHSHYINANYIKGY-YDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSDDEV--
 .||||.|.|   ...||.| .|..  . |.|||||||||| ...| |.||| |  .| ..||||......  |||||.. .. .     |.| . ..  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--CYGDIVVRADRNIELPNYVIRGFKVFNKRDrgkkERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDS--KECGPVVVHCSAGVGRTGTIIALDI
   |||. .. .  .|  .| .| . . .  .    ||..  . |  ||....| .|...||... .......  ....|||||||||.||||  || .|
serygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
|. ||. |. ||. .||  ||..|  |||.  |. .|..|. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 529-758 2.5e-51 169.1 In-house 7-238 (239) alignment
Range on Protein: 529-758
Range on HMM: 7-238/239.0
DHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPsDDEVCYG
...|||. .| ..||.||||..    ||| ||||.|.. |    | |||||   . .. .||||.|... . ||||| ... .     .||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DIVVRADRNIELPNYVIRGFKVFNKrDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS
.. |   .   . .|.|| | . .      .|| . |.|.  ||.| ||  |. || . | |   .    . | |.||||||||||... .|  | | | 
nlrvtlrktevfadyiirtfvmsqv.g.qteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.. |||   || .|..| .|||   |.|||. ||||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 529-758 3.9e-51 168.5 In-house 8-239 (239) alignment
Range on Protein: 529-758
Range on HMM: 8-239/239.0
DHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPsDDEVCYG
...|||. .| ..||.||||..    ||| ||||.|.. |    | |||||   . .. .||||.|... . ||||| ... .     .||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DIVVRADRNIELPNYVIRGFKVFNKrDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS
.. |   .   . .|.|| | . .      .|| . |.|.  ||.| ||  |. || . | |   .    . | |.||||||||||... .|  | | | 
nlrvtlrktevfadyiirtfvmsqv.g.qteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.. |||   || .|..| .|||   |.|||. ||||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 529-765 2.4e-21 70.7 In-house 47-284 (303) alignment
Range on Protein: 529-765
Range on HMM: 47-284/303.0
DHTKNRFKDIGAFDHTRVVLQEtpgvphSHYINANYIKgYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTI--VMLTNVVDSFK---YWP-SDDEVCYG
.  |||| |.  .||..| | .      | || |.|..    .|  | || |   |. .||.|. |||   .  ..  .  |..     .|  .| . . 
nmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DIVVRAD--RNIELPNYviRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQAS-HVLDFMRAINSA-NDSKECGPVVVHCSAGVGRTGTIIALDIALE
. ..|    ...|| .     .||      |.    .   || .|| ...|...| ...  .  ..|      .. | |    .|.||.||.  .. |  
ersirvgefkrvelgdg..wvlkvlsv.sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

QLKSEN-RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDM
 |.||.  .|.   .. .|. | . ||.|.|| ..|  . | ..   .
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 529-683 1.7e-19 64.8 In-house 32-192 (297) alignment
Range on Protein: 529-683
Range on HMM: 32-192/297.0
DH-TKNRFKDIGAFDHTRVVLQEtpGVPHSHYINANYIKGY--YDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE--
    |||..|| |.| ||| |.   ... . ||||.|.       |  || .| | ..| |.||..|.||   .|||.... .      . |||| ..  
sslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VCYGDIVVRA--DRNIELPNYVIRGFKVFNKrdrgKKERTILQFHYITWPNKNVPAQASHVLDFMRA
   ||.||    .   |  . ..  .... .    ...| .    ...||.. ||..   .  |   
lkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaq

Y_phosphatase Protein-tyrosine phosphatase 530-758 4.1e-74 244.3 Pfam-A 2-235 (235) alignment
Range on Protein: 530-758
Range on HMM: 2-235/235.0
HTKNRFKDIGAFDHTRVVLQETPGVPHshYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWP--SDDEVCYG
..|||.||| ..|.||| |....|     ||||||.||| ..| .|||| | |.|.. ||||||..|. .|||||.....      .|||  ..... ||
kkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIVVRAD-RNI-ELPNYVIRGFKVFNkRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQL
|| |.   ..  .  .|..| ... . ... ...|.. |.|| .||...||......||..|.... . ... ||||||||||||||||..||||.||||
dikvelkekekedekeytlrklelkk.kkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
..|. ||.  ||| ||.|| .|||.| |..|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 530-758 4.1e-74 244.3 In-house 2-235 (235) alignment
Range on Protein: 530-758
Range on HMM: 2-235/235.0
HTKNRFKDIGAFDHTRVVLQETPGVPHshYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWP--SDDEVCYG
..|||.||| ..|.||| |....|     ||||||.||| ..| .|||| | |.|.. ||||||..|. .|||||.....      .|||  ..... ||
kkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIVVRAD-RNI-ELPNYVIRGFKVFNkRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQL
|| |.   ..  .  .|..| ... . ... ...|.. |.|| .||...||......||..|.... . ... ||||||||||||||||..||||.||||
dikvelkekekedekeytlrklelkk.kkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
..|. ||.  ||| ||.|| .|||.| |..|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 530-758 1.5e-54 179.7 In-house 4-237 (237) alignment
Range on Protein: 530-758
Range on HMM: 4-237/237.0
HTKNRFKDIGAFDHTRVVLQETPGVphSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDE-VCYG
. |||. .| |.||.||||. . .   | ||||.|.||.    | |||.| | . .||.||.|||..|   ||||| ...       ||||| |.  .||
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

DIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRA-INSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLK
 . |   .. |. .| .| . ....  . |. | | |... .||.. || |.. .| | .  || ..   |.|| ..|||||||||| .. .|  | | |
vltvslkkkeefsdytvrslllskr.ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

SENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 .. |||   |. . ..|  ..|   |.|||....||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0041856 (Phosphotyrosine protein) phosphatases II 530-763 5.2e-48 158.4 In-house 2-174 (182) alignment
Range on Protein: 530-763
Range on HMM: 2-174/182.0
HTKNRFKDIGAFDHTRvvlqetpgvpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTnvvdSFKYWPSDDevcygdivvrad
..|||..||  .||.|          ...|||||.. |.. .. .|||| | ..|. .|.||..|..  |||.||    .. |||..             
ldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpell............

rnielpnyvirgfkvfnkrdrgkkERTILQFHYITWPNKNVPAqASHVLDFMRAINSandskECGPVVVHCSAGVGRTGTIIALDIALEQlksenRVDIE
                        ||...|..|. ||  .||   ...|||......     | |||.||||||||||||..|... ...     .|..|
........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

GIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYG
 .|| .|..| .||. . |..|.. |.|| . ..
eavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 530-784 3.3e-18 60.8 In-house 19-274 (290) alignment
Range on Protein: 530-784
Range on HMM: 19-274/290.0
HTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKgYYDDKLYIATQYPSKET-------CDNFWRMVWEQKTVTIVMLTNVVDS------F---KYW
| ...  ..  . .|||||..      . || ||... . ..   |.|| | ...         .|| |. . |   .||| .. .       |   || 
hemdqRlevpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PS--DDEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINsandsKECGPVVVHCSAGVGRTGTII
|   ..|. .... |.    ..  .  .|   |  | | ...| |.    .  | . ||. .   .|. .. ..     ..  ||.|||  |. |  .. 
pesvgeelkfkgltvkCkskekeddvetRelvv..kfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAala

ALDIALEQLK-SENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLedivygdmsTLIDEFSNHYIKSQEEAT
|....   .  ... | .| ..|.||.|| .....  .. |.  ...          |. |. ........|  
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqfaeeetekk

subfamily_CG42327_pd Subfamily CG42327 532-686 1e-22 75.2 In-house 31-192 (319) alignment
Range on Protein: 532-686
Range on HMM: 31-192/319.0
KNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDD-KLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPS----DDEVCY
|.|. ..  . .||||||. .  ....|..|.|..|| |    |||.| . ...  .|||.||||.. .|| ||.. .       .|.|.    |..  |
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYiTWPNKNVPAQASHVLDFMRAINS
||| |    .    .|.|  . .  ||  ... | .  . |  |.. .|||. . ..  .  ..|
Gdilvtlkgrevkdryaistlll..krvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 532-608 2.9e-08 27.6 In-house 37-112 (332) alignment
Range on Protein: 532-608
Range on HMM: 37-112/332.0
KNRFKDIGAFDHTRVVLQETPGvpHSHYINANYIKGYYDDKLYIATQYPSKETC-DNFWRMVWEQKTVTIVMLTNVVD
 ||   . .|||.|| |    |  .  . ||... ||     || .| | ..     ||||| |.|   |... .. .
mnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide

subfamily_eak_pd Subfamily eak 540-674 2.7e-10 34.1 In-house 62-198 (332) alignment
Range on Protein: 540-674
Range on HMM: 62-198/332.0
AFDHTRVVLQETPGVpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDD--EVCYGDIVVRADRNI
 .|.  | |  .    .  ||||  ..     . || |  .|..    ||.|| |||. .||.| . |.     | ||.| .   |. .| . |     .
pydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefv

ELPNYVIRGFKVfnkrDRGKKERTILQFHYITWPNKNVPAQA
.  ..  | ...     .| .   .| ...  | . ..|   
krniletrllel....skGnethrvlhykvfGwtettlpkye

0044763 (Phosphotyrosine protein) phosphatases II 541-755 6.4e-35 115.7 In-house 2-166 (178) alignment
Range on Protein: 541-755
Range on HMM: 2-166/178.0
FDHTRVVLQETPGVPHSHYINANYIKGYyddkLYIATQYPsketcDNFWRMVWEQKTVTIVMLTNV-----VDSFKYWPSDDEvcygdivvradrnielp
.|.|||.|.. .|.. | ||||..| ..    ||.....|      .......|..  .||.||.      .....|||.. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

nyvirgfkvfnkrdrgkkertiLQFHYITWPNKNVPAQASHVLDFMRAINSANDsK-EcGPVVVHCSAGVGRTGTIIALDIALEQlksenRVDIEGIVKV
                      .|...| .|  .||   .|.|.|...|..| | . . |||.|||||||||.||..|... ...     ....| ... 
......................iqylhipipDhgvpdllehflefvefieeald.ekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRQQRTqMVQELCQFVFIYNA
.|..|  .|.   |  ..|  
vrerRp.ivpnpgqlrqLyef

0046846 (Phosphotyrosine protein) phosphatases II 548-757 1.3e-38 127.8 In-house 3-170 (176) alignment
Range on Protein: 548-757
Range on HMM: 3-170/176.0
LQETPGVPHSHYINANYIKGYYddklYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYgdivvradrnielpnyvirgf
|...   ....|||||.| |..    .||||.|  .|. .|..|..|..  ..|.||. |.      . |||   .. .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvfnkrdrgkkertilQFHYITWPNKNVPAQaSHVLDFMRAINSANDSKecGPVVVHCSAGVGRTGTIIALDialeQLKSENRVDIEGIVKVLRQQRT-Q
                |.... ||  .||   ...|.....|..| ...  |||.||||||.|||||..|..     |..|. ...| ... .|.||  .
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQELCQFVFIYNAVL
.||  .|  |.| ..|
avqtpeQyrflyefel

0051429 (Phosphotyrosine protein) phosphatases II 554-759 1.4e-47 157.9 In-house 1-224 (272) alignment
Range on Protein: 554-759
Range on HMM: 1-224/272.0
VPHSHYINANYIKGYYD---DKLYIATQYPSKETCDNFWRMvWEQKTVTIVMLTNVV-----DSFKYWP------------SDDEVCYGDIVVRADRNIE
.| |.||||....||.    .........|.. |...|||. .|..  |||.|....     . ..|||            |. .. ||...|.    . 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPNYVIRGFKVFNKRDRGKKeRTILQFHYITWPNKNVPAQAshVLDFMRAINSandskeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVD------
|..|..| . . .. . |.  |.....||. ||  .|| .|  .|........       |||.||||||..||||..||.. |...  |  ||      
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
  .|..|. ||.|| ..||   |..|.|.|.|| 
lyleeaveelraqrpgavqteeqylflyeallel

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 554-626 2.3e-07 25.2 In-house 10-84 (130) alignment
Range on Protein: 554-626
Range on HMM: 10-84/130.0
VPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFKYWPSDDEVC-Y-GDIVV
..  .||||...      . |. || |  .|. .||.|. |.    .|.|  | .  .|||  . .  |  ||.|
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediiv

0043147 (Phosphotyrosine protein) phosphatases II 555-753 3.3e-42 139.5 In-house 3-154 (172) alignment
Range on Protein: 555-753
Range on HMM: 3-154/172.0
PHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVvdsfkywpsddevcygdivvradrnielpnyvirgfkvfnKRDRGKKE
..|.||||.|...||  . .||||.|  .|.. ||||..|..  .||.||.                                           |. . |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpelle

RTILQFHYITWPNKNVPaQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALeqlkseNRVDIEGIVKVLRQQRTQMVQELCQFVFIY
|...|..|. ||  .||  ....|.|.. |...   .. |||.||||||||||||..|... |       ....| .|. .|..| ..||   |  |.|
rlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

0051082 (Phosphotyrosine protein) phosphatases II 555-757 2.5e-34 113.4 In-house 1-150 (151) alignment
Range on Protein: 555-757
Range on HMM: 1-150/151.0
PHSHYINANYIKGYyddklYIATQYPSKetcdNFWRMVWEQKTVTIVMLTNVV---DSFKYWPSDDevcygdivvradrnielpnyvirgfkvfnkrdrg
|.|.|||..|. |.     ......|.      |.....|..  |||.|.. .      .|.|. .                                  
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................

kkeRTILQFHYITWPNKNVPAQASHVLDFMRAINSandsKECGPVVVHCSAGVGRTGTIIALDIALEQlksenrVDIEGIVKVLRQQRTQMVQELCQFVF
   ...|..... ||. ..|     ||.|......    |. |||.||||||.|||||..||.. |..      |..| ... .|..|. .||   ||.|
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IYNAVL
.. |.|
qlfall

0036282 (Phosphotyrosine protein) phosphatases II 557-753 3.3e-42 139.5 In-house 2-163 (174) alignment
Range on Protein: 557-753
Range on HMM: 2-163/174.0
SHYINANYIKGYYDDKLYIATQYPSKetcdnFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSddevcygdivvradrnielpnyvirgfkvfnkrDRG
|.||||......|  . .||.|.| .     ||.|..|..  |.|||.. .       . |||.                                 .| 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

KKERTILQFHYITWPNKNVPAQAShVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKsENRVDIEGIVKVLRQQRTQMVQELCQFVF
  ||...|..|. ||  .||  .  .|.|......|  ... |||.||||||||||||..|... | .|. |. ||.  .|. ||.|| .|||   |. |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IY
.|
ly

0049260 (Phosphotyrosine protein) phosphatases II 564-754 1.6e-35 117.4 In-house 1-144 (152) alignment
Range on Protein: 564-754
Range on HMM: 1-144/152.0
YIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWpsddevcygdivvradrnielpnyvirgfkvfnkrdrgkkertil
.|.||.  . .||||.|  .|...||||..|..  ||||||. ..       .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFHYITWPNKNVPAQASHVLDFMRAINSAnDSKECGPVVVHCSAGVGRTGTIIALDIALeqlkseNRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
|.... ||  .||  . ..|.....|. .   .. |||.||||||||||||..|... |      ..|..| .|. .|..| ..|.   |  |.|.
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 566-626 5.7e-07 23.2 In-house 230-293 (440) alignment
Range on Protein: 566-626
Range on HMM: 230-293/440.0
KGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS--FKYWPSDD-EVCYGDIVV
.||   . .|||| |   |  .|||.| . .  ||.|| .. |     ||| .   | .| . |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 571-754 7.3e-25 82.3 In-house 4-198 (199) alignment
Range on Protein: 571-754
Range on HMM: 4-198/199.0
DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDE--VCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYI
.. |||||.| .||  .||.||||  .  |||. .       |   |||. .     || . | .      |.|.|  . . |.       | | .. . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPNKNVPAQASHVlDFM---RAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
.| .|  |  |  |  |.   | .    . .   ||.|||| | | || ..|||| .   .      ||.  . | ||| |  ..  | .. |||.
swkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 572-754 7.5e-25 82.3 In-house 4-197 (198) alignment
Range on Protein: 572-754
Range on HMM: 4-197/198.0
KLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDE--VCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYIT
. |||||.| .||  .||.||||  .  |||. .       |   |||. .     || . | .      |.|.|  . . |.       | | .. . .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPNKNVPAQASHVlDFM---RAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
| .|  |  |  |  |.   | .    . .   ||.|||| | | || ..|||| .   .      ||.  . | ||| |  ..  | .. |||.
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 574-627 1.9e-06 21.7 In-house 139-194 (244) alignment
Range on Protein: 574-627
Range on HMM: 139-194/244.0
YIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFKYWPSDDEVCY--GDIVVR
|| ||.|  .|  .||.|. |..   .|.|  | .  .|||  . . .   || | 
yiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvt

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 577-756 1.2e-17 58.3 In-house 96-284 (302) alignment
Range on Protein: 577-756
Range on HMM: 96-284/302.0
TQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPS--DDEVCYGDIVVRA-DRNIELPNYVI-RGFKVF-----NKRDRGKKERTILQFHY
   | |.|.. .| .. . ..  .| |...|..      .|.    ..|. .|   |.. . . .| ..   ..||..     |.. . |...|.  ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

ITWPNKNVPAQASHVLDFMRAINSANDSkecgpVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAV
 .||..  |..| . || ..  .|   .     |.||||||||||||..|.   ..  . ..  |.  ||. .|| |   ||.  | ...   |
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv

subfamily_hpo-7_pd Subfamily hpo-7 583-777 1.1e-13 45.7 In-house 45-248 (263) alignment
Range on Protein: 583-777
Range on HMM: 45-248/263.0
ETCDNFWRMVWEQKTVTIVMLTN-----VVDSFKYWPS--DDEVCYGDIVVRADRNIElpNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQAS
.| |.|....  .|| ..|||..     |..  .|.|   |.   . .. | . . ..  . ...  .. .  .. || .|. .. |  |..|| | .| 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

HVLDFMRAinsANDSKEcgpVVVHCSAGVGRTGTIIALDIALE----QLKSENRVDI--EGIVKVLRQQRTQMVQELCQFVFIYNAVLE----DIVYGDM
 .|  ...   | .||.   .|||||.|.||.      ...      .|.  . |..    ... ||..|.. ...  |. |    ||.    .   |..
eilnilkv...arnsks...lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel

STLIDEFSNHYI
..  .|  . |.
eakyqeirksyl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 584-776 8.9e-17 56.0 In-house 40-238 (255) alignment
Range on Protein: 584-776
Range on HMM: 40-238/255.0
TCDNFWRMVWEQKTVTIVMLTNV-----VDSFKYWPS--DDEVCYGDIVVRADRniELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASH
| |.|....  .|| ..|||..      ..  .|.|   |.   . |. | . .     . |.|  ..  .  . || .|.  ..|  |..|| | .|  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLDFMRAInsaNDSKecgPVVVHCSAGVGRTGTIIALDIALE----QLKSENRVD--IEGIVKVLRQQRTQMVQELCQFVFIYNAVLeDIVY--GDMSTL
.|  ....    |||   .||||||.|.||. . .  ...      .|.  . |.     ... ||..|.. ...  |. |    || |.|.  |..   
ilnilkvv...rdsk...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl.dlvfpkgeleak

IDEFSNHY
  |  . |
yqeirksy

subfamily_PTEN_pd Subfamily PTEN 641-742 3e-06 22.4 In-house 61-162 (184) alignment
Range on Protein: 641-742
Range on HMM: 61-162/184.0
GFKVFNKRDRGKKERTILQFHYITWPN-KNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIaLEQLKSENRVDIEGIVKVLRQQR
 .|..| |   | . . .. . ...|   . |.. . . .... |..  ....   ||||| || ||||..|.  . |..|. |.  ..  . .  | . 
hykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayl.lkslllekaeealelfaeaRtkn

TQM
.. 
kkg

0048076 (Phosphotyrosine protein) phosphatases II 644-756 1.7e-25 84.8 In-house 36-139 (145) alignment
Range on Protein: 644-756
Range on HMM: 36-139/145.0
VfnKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKecGPVVVHCSAGVGRTGTIIALDIALEqlkseNRVDIEGIVKVLRQQRTQMV
.   ...   ||...|..|. ||  .||  ....|.|...|..| ...  |||.||||||||||||..|... |.     ..|..| ... .|.|| ..|
l..tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

QELCQFVFIYNAV
.   |. |.| ..
pnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 645-754 1.7e-24 81.6 In-house 37-139 (144) alignment
Range on Protein: 645-754
Range on HMM: 37-139/144.0
FNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKecGPVVVHCSAGVGRTGTIIALDIALeqlksENRVDIEGIVKVLRQQRTQMVQ
 ....    ||...|.... ||. .||  ....|.|...|..| ...  |||.||||||||||||..|... .     ......| ... .|..| ..|.
teeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavp

ELCQFVFIYN
   |. |...
npgqlrfLle

PTEN_1 649-712 1.5e-09 32.9 In-house 86-149 (196) alignment
Range on Protein: 649-712
Range on HMM: 86-149/196.0
DRGKKERTILQFHYITWPNKNVPAQAShVLDFMRAINSANDSKEC-GPVVVHCSAGVGRTGTIIA
|  . ..  .... . ..  ..|  .. ..|. . . ..  |... . |.||| ||.||.||..|
dleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 650-758 2.6e-20 67.3 In-house 181-285 (305) alignment
Range on Protein: 650-758
Range on HMM: 181-285/305.0
RGKKERTILQFHYITWPNKNVPAQASHVLDFMRainSANDSKecGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVD-IEGIVKVLRQQRTQMVQELCQ
 |.| | . ..|.| ||.. |||    .|...     |  ||  ||.|||||||.||||... |.  |.|| . . ..  . |.. .|.|| . .|   |
pgekarkvthyhwidwpdrgvpaadlailelle...karpsk..gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq

FVFIYNAVLE
..|... .|.
ylfvhqviln

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 650-760 5e-08 25.9 In-house 199-309 (346) alignment
Range on Protein: 650-760
Range on HMM: 199-309/346.0
RGKKERTILQFH-YITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVhCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQ
 |. .  | | | .  |   . | ..  .. ..  . | .. .. |  ||    | ||. ..|    |..||      .|  |.| ..|||   |. . |
egnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaq

FVFIYNAVLEDI
.  ||  |.. |
yasiyaivfdyi

PTPc_motif_SM00404 650-750 1.8e-07 26.1 In-house 42-131 (140) alignment
Range on Protein: 650-750
Range on HMM: 42-131/140.0
RGKKERTILQFHyIT-WPNKNVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIALdialEQLKSENrVDIEGIVKVLRQQRtQMVQELCQ
. .....|||   .    .... .. . ||||....      |. | |.||| ||| |..|.|.     . ..... ....  .......| .....  .
kensgfqilqip.lddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliia....Ylmryrq.lslaeayefvkerR.piispnln

FV
||
fv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 651-775 8.2e-28 91.9 In-house 85-209 (440) alignment
Range on Protein: 651-775
Range on HMM: 85-209/440.0
GKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFV
| . ||. |.||  ||.| ||  |. || ... .| ...    ||..||||||.|||| |||.|  | . |  ...||  ... .|..| ||||   |..
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIYNAVLEDIVYGDMSTLIDEFSNH
|...|||| .. ||   | |. ...
fvheavlegllcgdtliledditer

0048567 (Phosphotyrosine protein) phosphatases II 652-713 9e-07 23.4 In-house 25-97 (157) alignment
Range on Protein: 652-713
Range on HMM: 25-97/157.0
KKERTILQF------HYITWPNKNVPAQASHVLDFMRAINSAND--SKECGPVVVHCSAGV---GRTGTIIAL
|.  . |.|      .|...  .. |   ... .|.. .|.  .  ... ....|||.||    |||.|.|..
kslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc

PTPc_DSPc_SM00012 657-758 2.8e-35 116.0 In-house 2-105 (105) alignment
Range on Protein: 657-758
Range on HMM: 2-105/105.0
ILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKE-CGPVVVHCSAGVGRTGTIIALDIALEQLKSE-NRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
. ..|| .||...|| .....|...||... .  .|  .|||||||||||||||..||||.|.||..| ..|||. ||| ||.|| .|||.. |..|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle

0038934 (Phosphotyrosine protein) phosphatases II 658-713 4.2e-10 35.1 In-house 80-135 (194) alignment
Range on Protein: 658-713
Range on HMM: 80-135/194.0
LQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIAL
.... . .|..... . . .|.|.....  .. .. | |.||| ||.|||||..| 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_PTPDC1_pd Subfamily PTPDC1 659-749 1.8e-08 29.0 In-house 84-165 (182) alignment
Range on Protein: 659-749
Range on HMM: 84-165/182.0
QFHYITWPNKNVPAqASHVLDFMRAINSANDSKecgPVVVHCSAGVGRTGTIIALDIALeqlksENRVDIEGIVKVLRQQRTQMVQELCQF
 .. ..|.. .|..   ..|| .. ...| . .    | ||| || |||| .||  .        .|.. |  .|..|..|.. .|   | 
yvynfgwkDygvas.leriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqv

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 661-751 1.1e-07 25.7 In-house 233-329 (347) alignment
Range on Protein: 661-751
Range on HMM: 233-329/347.0
HYITWPNKNVPAQASHVLDFMRAINSAN-D-----SKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVF
   ||| |. | .  .|| ..||             .   |||| |  |. |. |..   | .||. . .  | . . | .|.||. .      . .
ncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifyty

subfamily_DSP23_pd Subfamily DSP23 661-743 1.5e-07 26.2 In-house 55-129 (148) alignment
Range on Protein: 661-743
Range on HMM: 55-129/148.0
HYITWPNKNvPAQASHVLDFMRAINSANDSKECgpVVVHCSAGVGRTGTIIALDIALEQlkseNRVDIEGIVKVlRQQRTQMV
. .  ..   |     | .|.| .. |.. .|   | |||  | |||||..|  .  |.    .    | | .| |..|   |
vrlriddyh.ppaleqvvefvrvveeaeeknea..vsvhcllgrgrtgtmlacylvker....klaaaeaiaev.rrlrpgsv

DSPc Dual specificity phosphatase, catalytic domain 669-713 7.5e-06 20.8 Pfam-A 54-93 (133) alignment
Range on Protein: 669-713
Range on HMM: 54-93/133.0
NVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIAL
.. .. . . .|....      .. . |.||| ||. |..|.|. 
kiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliia

DSPc Dual specificity phosphatase, catalytic domain 669-713 7.5e-06 20.8 In-house 54-93 (133) alignment
Range on Protein: 669-713
Range on HMM: 54-93/133.0
NVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIAL
.. .. . . .|....      .. . |.||| ||. |..|.|. 
kiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliia

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 675-757 7.1e-17 56.1 In-house 245-341 (350) alignment
Range on Protein: 675-757
Range on HMM: 245-341/350.0
SHVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALE------QL-------KS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
....| . | .   |...  |..||||||||||||...||  |.      .|       .   . |  |. ||. ||.|| .|||.| ||.|||.|.|
ndliddlfaesh.ldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 676-758 3.4e-13 43.6 In-house 249-342 (349) alignment
Range on Protein: 676-758
Range on HMM: 249-342/349.0
HVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALE----QLKSENRVD--------IEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
...| . | .   |...  ...|||||| ||||... ||. |.      .  |...        |  ||  ||.|| .|||.| ||..||.|.|.
dliddlfarly.ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_CDC14_pd Subfamily CDC14 680-715 6.8e-06 20.1 In-house 255-285 (328) alignment
Range on Protein: 680-715
Range on HMM: 255-285/328.0
FMRAINSAndskeCGPVVVHCSAGVGRTGTIIALDI
|......|      | ..||| ||.|||||.||  .
fleiaeka.....eGaiavhCkaGLGrtGtLiacyl

subfamily_CG42327_pd Subfamily CG42327 689-756 5.5e-20 66.3 In-house 243-311 (319) alignment
Range on Protein: 689-756
Range on HMM: 243-311/319.0
DSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSE-NRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAV
  .. ||.||||| ||||||..|| |||...|.   . |||  .|  .|..|.. |..  |. |||. .
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 695-760 3.6e-15 50.6 In-house 230-295 (297) alignment
Range on Protein: 695-760
Range on HMM: 230-295/297.0
PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDI
...|||||||||.| ..  |. |..|. .   |.  |...||.||...|| | || ..|.|||. .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 697-761 7.5e-15 49.1 In-house 2-66 (69) alignment
Range on Protein: 697-761
Range on HMM: 2-66/69.0
VVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
|||||.| |||||.||. . . ..|||  |||   |. .|. |  || .  ...||..|. | . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 697-763 4.4e-14 46.6 In-house 1-67 (69) alignment
Range on Protein: 697-763
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYG
|||||.| ||||| ||. . . ..|||  |||   |. .|. |  || .  ...||..|. | .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

0050432 (Phosphotyrosine protein) phosphatases II 773-1027 7.3e-26 86.6 In-house 32-303 (308) alignment
Range on Protein: 773-1027
Range on HMM: 32-303/308.0
SNHYIKsQEEATLITDEFNKIGAVKPPAQSYSGP-----------SVVPFDY------GEETMFTAHYLDGY--WTPNLFIKSPCPTKDNTECFWRLIIH
 ... | . . .|.  ||... .|||. . ...            ...|.|.      .. .   | | |||  . |. ||    |.....| |||.. .
lkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

KKCSHIINLSPTDADT----YSYISEFGT-TGLKFGAITISVGRKKEfNAGFLTRDINIRNEEDSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLV
 ....|. |  .. .     . |  .    . |..| .|. . . .. .... .| . ..| .|.  ..|. ..| .    |. |  .. ...|....  
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeilldflelvrk

QVeschhGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNKLL
.      ...||. |     |  | |..| ..|.. .||. .....| ..   | || . ... | ..|..|.|| ...|
sl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0051299 (Phosphotyrosine protein) phosphatases II 780-1022 1.7e-27 92.0 In-house 19-285 (288) alignment
Range on Protein: 780-1022
Range on HMM: 19-285/288.0
QEEATLITDEFNKIGAVKPPAQSYSG-----------PSVVPFDY-----------GEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCS
.   |.. .||... ...|. . ...           ....|.|.           .. .   | |.|||.... ||    |.....| |||.. .....
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

HIINLSPTD----ADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNE----EDSMLLRVKYIQYQDMFlKHCFPR-VDKFMKFIQYCLVQ
.|. | ...     . . | ..   . |..| ||.   . .. .... .| . ..|      |.  ..|. ..| .    |..|  .. ...|....  .
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrka

VEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEY
 .   .|..|.. |     |  | |..| ..|.. .||. ...|.| ..   | ||.. ... | ..|..|.||
la...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 782-871 2.9e-25 83.6 In-house 18-130 (439) alignment
Range on Protein: 782-871
Range on HMM: 18-130/439.0
EATLITDEFNKIGAVKPP--------AQSYSGP-----SVVPFDYGEETM-----------FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCS
.  .....|.||....|.        ||.|...     .|..||....|.           ..|.|..||....|.|....|.|..|..||||.|.||..
kqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

HIINLSPTdADTYS
.|..|.    ..| 
tivmltnl.vesyk

0039614 (Phosphotyrosine protein) phosphatases II 786-1026 1.5e-27 92.3 In-house 34-292 (297) alignment
Range on Protein: 786-1026
Range on HMM: 34-292/297.0
ITDEFNKIGAVKPPAQSYSGPS---------VVPFDY------------GEETMFTAHYLDGYWT-PNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLS
.  || ..  .||.   .  |          ..|.|.             . .   | |.|||.  .. || .  |.....| |||.. . ....|..| 
lllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLt

PTDAD---TYSYISEFGTtglKFGAITISVGRKKEfNAGFLTRDINIRNeeDSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVESChHGNHPI
... .    ..| .| |.   ..| .|. . . .. ..|. .| ....|  ..  . |. .|| ..   |. |  .. ...|....  ..... ....|.
klvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslellleflelvrealael.pkggpv

LMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNKL
| |  .  |  | |... ..|.. .||. ...|.| ..   | || . ....| ..||.|.|. .. 
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0047943 (Phosphotyrosine protein) phosphatases II 807-1022 1.5e-28 95.4 In-house 53-271 (273) alignment
Range on Protein: 807-1022
Range on HMM: 53-271/273.0
SVVPFDYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTT-GLKFGAITISVGRKKEfNAGFL
| |  . |.  .  | |.|||.... ||    |.....| |||.. ......|. | ... .     . | .. | .  |..| .|. . . .. .... 
srvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddyt

TRDINIRNEEDSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVESCHHGnHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYL
.| . ..| ...  . |....| .    |. |  .. ...||...  . |..... .|.. |  .  |  | |..| ..|.. .||. ...|.| ..   
vrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrs

QSPGLIVNLQFYAYCYDCLMEY
| || . ....| ..|..|.||
qRpgmvqtpeqyrflyealley

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 808-1030 6.5e-17 56.4 In-house 49-266 (267) alignment
Range on Protein: 808-1030
Range on HMM: 49-266/267.0
VVPFDYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYI--SEFGTtGLKFGAITISVGRKKEFN-AGFLTRD
.|..   ||    | |..|| | | ||    | |     |. .|...|.. |. | ..  |    .   ..|    |.  .|.    .|| |    .| .
rvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgq.akkyqdltvehslekeendyqiitle

INIRNEEDSMllrVKYIQYQDMFLKHcfpRVDKFMKFIqYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPG
....||       |    |.   ..        ..| . . ..  .    ||.|.... .   |  | | ..   |.|||.| . .| .   .   | .|
lkfknesahn...vtlyyykkwnint...nnkpylkpl.fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrig

LIVNLQFYAYCYDCLMEYSNKLLKEE
|.  .. | |... | ||..  ||||
lvdtkeryiyihellaeyaegrlkee

0036941 (Phosphotyrosine protein) phosphatases II 812-1026 4.6e-27 90.5 In-house 59-280 (297) alignment
Range on Protein: 812-1026
Range on HMM: 59-280/297.0
DYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTTGLKFGAITISVGRKKEF-NAGFLTRDIN
| ..   . | |.|||. .. ||    |.....| |||.. . ....|..|.. . .     ..| ..     |..| .|. . . ... .... .| . 
ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtle

IRNEEDSMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVeSCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAK---KERIINILQAANHHYLQSP
. . ...  ..|....| .    .. . .. ...||.... .  .   ...|.| |  .  |  | |... ..||. .   ||. ..||.| ..   | |
vtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRp

GLIVNLQFYAYCYDCLMEYSNKL
| . .|..| ..|..|.|. .| 
gavqtleqyrflyeallellkkk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 812-1036 1.1e-06 22.4 In-house 69-247 (392) alignment
Range on Protein: 812-1036
Range on HMM: 69-247/392.0
DYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP-TDADtysyisefgttglkfgaitisvgrkkefnagfltrdiniRNE
|  ..  . | |.... . . .| |  |     . |||.. ... . |. ..   ..|                                       . .
dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......................................kgd

EDSMLLRVKYIQYQDMF-LKHcfprVDKFMKFIQYCLVQVESChhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
..    . .. .. |    ||    .  ..|||.   ..  .     ||...|     |  |.  ..   . .||| |......       . | ..   
dartvaqfhftewPdkdvpkh....tssllkfikevkadfGqy...thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

QFYAYCYDCLMEysNKLLKEEYFPSIH
. ||. | ...|  . | ..   | .|
eqyafiygavle..dllwrntlipvvh

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 815-1023 7.7e-14 46.2 In-house 71-277 (315) alignment
Range on Protein: 815-1023
Range on HMM: 71-277/315.0
EETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT---DA-DTYSYISEFGTTGLKFGAITISVGrKKEFNAGFLTRDINIRNE
..  . | |. .. . . .| |  | |   . |||.....| . |. ..     |      |  .  .   .||.| ...  . | ...  .| . .|. 
dsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvell.sleadtdgvarklvtrks

EDSMllRVKYIQYQDMFLKHCFPRVDKFMKFIQYclVQVEsCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.|   .|   |...   |    ..  ..|.|.   |. .  .. ....|.|     |  |.. ..  .....|..| .....  .    . | |.   .
eesr..tvtqfqftewPdkGvdkqtssllklike..vkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqtee

FYAYCYDCLMEYS
 ||. || ..|. 
eyafiydavledl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 815-1022 1.6e-09 31.9 In-house 69-292 (301) alignment
Range on Protein: 815-1022
Range on HMM: 69-292/301.0
EETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTTGLKFGAITISVGRKKE---------------
...   | |.|||   . || .  | |     |||||...| ..|. .  .. .    .. | ..  ..  .|| .|. .  ..                
qreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd

-FNAGFLTRDINIRNEEDSMllRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESchHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQA
 .| |.. | ...... .|.   |  .|  |       .     .. |.  . .  .   |  |.. |   . .  |.. ...  |  .| | .... | 
gsnngyierkfkvksdkssw..dvlqlqvtdWpqdGvvreprtvLqviddvihrqqk..igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqv

ANHHYLQSPGLIVNLQFYAYCYDCLMEY
 .    . || .  |. |   || . .|
tkavrrskpgaVtTLeqytsiydvidmy

0043336 (Phosphotyrosine protein) phosphatases II 816-1022 1e-26 89.5 In-house 73-276 (278) alignment
Range on Protein: 816-1022
Range on HMM: 73-276/278.0
ETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISefgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEE
 .   | |.|||. |. || .  |.....| |||.. . ....|..| . .       . | .    . |..| .|. . . .. .... .|.... |  
sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlg

DSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.  . |  ..| ..   |..|  .. ...|... . ..|   . |.|.| |  .  |  | |..| ..|....||. .....| ..   | || . ...
dgesrtvthyhylgwp.dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtps

FYAYCYDCLMEY
.| ..|..|.||
qyrflyealley

0037934 (Phosphotyrosine protein) phosphatases II 816-1022 2e-18 62.3 In-house 32-241 (243) alignment
Range on Protein: 816-1022
Range on HMM: 32-241/243.0
ETMFTAHYLDGYwtPNlFIKSPCPTKDNTEC----FWRLIIHKKCSHIINLSPTD----ADTYSYISefGTTglKFGAITISVGRKKEFNAgFLTRDINI
. .. | . ...  |. .| . .|.....|     |||.. . ....|..| ...     . . | .  |..   .| .|. .   ....  .  | . .
sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev..tygdftvtllseehldd.ytvrtlll

RNEE-DSMLLRVKYIQYQDMFlKHCFPR-VDKFMKFIQYCLVQVES-----CHHGNHPILMHDDGSNGPIGIFATLTYCLQRAkkeRiINILQAANHHYL
.| . |   . |  ..|  .   |. |  .. ...|....   .|.     . ....|.| |  .  |  | .... ..|..    . .....| ..   
enldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllre

QSPG-LIVNLQFYAYCYDCLMEY
| ||  . ....| ..|..|.|.
qRpgkavqtpsqyrflyeallel

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 816-1023 4.3e-14 47.4 In-house 76-288 (325) alignment
Range on Protein: 816-1023
Range on HMM: 76-288/325.0
ETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTY---SYISEFGTTGLKFGAITISVGRKKEFnAGFLTRDINIRNEED
   . | ||  .   . |. .  |  . .. .|||..  .|| .. |   | .      |  .      .||.. ...   .|. . .. | ..... ..
sdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkk

SMLLRVKYIQYQ---DMFLKHCFPRVDKFMKFIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
   . ||  |.|   ||  ..    .  ... ..    .| .  ..  |||.|     |  |.|..|   |..  .|  ..|..  ..   . | ..   
GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

QFYAYCYDCLMEYS
  |  .|..|.|. 
dqyiliyealveay

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 816-1037 9.2e-14 45.4 In-house 71-288 (515) alignment
Range on Protein: 816-1037
Range on HMM: 71-288/515.0
ETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA-DTY---SYISEFGTTGLKFGAITISVGRkKEFNAGFLTRDINIRNEE
.  | | |. .. . . .| |  | |  .. ||||..... . |. ..     |      |  .  .  .||| | ...    |  .| . | ...  ..
sdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvs.leactggikrkltvlkgd

DsmLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYclVQVESCHHgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
|     |   ....   |   ..   ..|.|.   |. .  .  .||...|     |  |.. ..  .. .||. |......  .    . | |.   . 
d..srtvtqfhfteWPdkGvpkhtssllklike..vkadhgqy.thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq

YAYCYDCLMEYsnKLLKEEYFPSIHE
||. |. ..|.   | ..   | || 
yafiygavled..llwrntlipvihf

0049772 (Phosphotyrosine protein) phosphatases II 816-1028 2.7e-06 22.8 In-house 72-285 (314) alignment
Range on Protein: 816-1028
Range on HMM: 72-285/314.0
ETMFTAHYLDGYwtpNLFIKSPCPTKDNTECF----------WRLII-HKKCSH--------------------------------IinlsptDADTYSY
  ...| |.||.   . || .  |.. . ..|          ||...  .  ..                                       .  | ..
sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng......neptaad

ISEFGttglkfgaitisvgrkkefnagfltrdiN---IRNEEDSMLLRVKYIQYQDmFLKHCFPRVDKFMKFIQYClvqveschHGNHPILMHDDGSNGP
. ..                             .    ..    . .....|   | .    .  .|.|..||. .        . ..|.|.|  .  | 
lellk............................eelydpelferlgikylripvpD.gsaplledfdeflefieea........dkggpvlvHCkaGkgR

IGIFATLTYCLQ--RAKKERIINILQAANHhYLQSPGLIVNLQFYAYCYDCLMEYSNKLLK
 | |... |..   .   | ... ...... .  .||.| .|. | .....|.|| ..|.|
tgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkk

0040439 (Phosphotyrosine protein) phosphatases II 817-1023 6.1e-28 93.5 In-house 40-246 (249) alignment
Range on Protein: 817-1023
Range on HMM: 40-246/249.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEED
 .  | |.|||. .. ||   .|... .| |||.. . ....|..|....     . . | ..   . |..| .|. . . .. .... .| . . | .|
dyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.kddytvrtleltnlyd

SMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
.  ..|. ||| |.   .. | .. ...||....  .|.. . ..|.| |  .  |  |.|... ..|.. .||. .....| ..   | || . |...|
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqy

AYCYDCLMEYS
 ..|..|.|. 
rflyeallell

0045450 (Phosphotyrosine protein) phosphatases II 817-1022 1.9e-26 89.0 In-house 93-303 (307) alignment
Range on Protein: 817-1022
Range on HMM: 93-303/307.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNE-E
...   .||||. .. ||    |.... | |||.. ......|..|.... .     . | ..   . | .| .|. . ....  .|.  | ... .  .
rvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldg

DSMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERI---INILQAANHHYLQSPGLIVN
... ..|....| .    .. | .. . .||....  .|..  ...|.| |  .  |  | |... ..|.. .|| .   ...|.| ..   | || . |
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn

LQFYAYCYDCLMEY
...| ..|..|.|.
peqyrflyeallel

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 817-1022 1.9e-21 71.5 In-house 75-282 (305) alignment
Range on Protein: 817-1022
Range on HMM: 75-282/305.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLS----PTDADTYSYISEFGTTGLKFGAITISVGRKKEFNaGFLTRDINIRN-EE
    | |.|||   . .| .  | |.  . |||||.. | |.|. |.      .   . |  |  |   .|| ... .  .|... ....|...| . .|
dyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektas.dyieRklkisiede

DSMLLRVKYIQYQDmFLKHCFPRV-DKFMKFIQycLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.    |   |  | .  |  |.    ....|.   || .  .  . |.| |   . |  |.| ..   |.|.||| .... .  ..   . .... .|.
dkesrtvlqyqltd.WPdhGvpqfatsllslik..rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtld

FYAYCYDCLMEY
 | ...| | |.
qYvflhdaldel

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 817-1024 3.9e-21 70.4 In-house 77-284 (319) alignment
Range on Protein: 817-1024
Range on HMM: 77-284/319.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGTTGL--KFGAITISVGRKKEfNAGFLTRDINIRNEEDSM
.   | ..|||   . ||    | .. .| |||.. ....| .. |.         .... ..    ..| ... .  ..|  ...  |......  . .
dyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeee.ledyiirklklnkkssev

-LLRVKYIQYQDmFLKHCFPRV-DKFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
   .||  ||.. .  |  |.     .....   ..    .. . || .|     |  | | .|   |.| |.| .... . ...  .| . .. . . |
etRevkhfqyte.WpdhdvPekatslldllkr..irksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqY

AYCYDCLMEYSN
 ..|. |.|. .
kfiyealleave

0041856 (Phosphotyrosine protein) phosphatases II 817-1023 1e-12 43.5 In-house 20-171 (182) alignment
Range on Protein: 817-1023
Range on HMM: 20-171/182.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSptdadTYSYISefgttglkfgaitisvgrkkefnagfltrdinirNEEDSMLL
.. .|....|.. .. ||    |.......|.|.. . ....|.||.      . |                                    ...  . .
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp..................................ellerlgi

RVKYIQYQDmflkHCFPRVDKFMKFIQYCLVqveschhGNHPILMHDDGSNGPIGIFATLTYCLQRakkeRiINILQAANHHYLQSPGLIVNLQFYAYCY
...|..  |    |. | .|.. .||. .|         ..|.| |  .  |  | .. . .....    . ... .| ..   . || ......| ...
qylylpwpD....hgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflq

DCLMEYS
..|.|. 
lallell

0043147 (Phosphotyrosine protein) phosphatases II 817-1016 4e-10 35.2 In-house 6-154 (172) alignment
Range on Protein: 817-1016
Range on HMM: 6-154/172.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTdadtysyisefgttglkfgaitisvgrkkefnagfltrdINIRNEEDSMLL
..  | |||.|. |. ||    |.  ... |||.. .....||.|| .                                         ...  .  . .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.......................................lydpellerlgi

RVKYIQYQDMFLKhCFPRVDKFMKFIQYCLvqvesCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANhhylqsPGLIVNLQFYAYCY
.. |. . |.     .  ...|..||.  |     .   ..|.| |  .  |  | .. . ..|.. . | ... ....       || . | ..| ..|
qylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvrekR......pgavqnpsqyrfly





subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 817-1002 7.4e-07 23.1 In-house 82-265 (290) alignment
Range on Protein: 817-1002
Range on HMM: 82-265/290.0
TMFTAHYLDGywTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEED
    | |..|  .   || .  ..|| .  .||.....| . |. |        |    |  |     | ||.||.    ... .|    . . .|. ..
dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkds

SMLLRVKYIQYQdMFLKHCFPRVDkfMKFiqycLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQR---AKKERIINILQAANHHYLQS
    ..|... .  .  .. .  .  . .    |  . .  . . |. .|     |  | |...  .||     |. ..... .|  .  |.|
Gkehklkhlkik.swpdksvalst..lal....lrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlns

0046845 (Phosphotyrosine protein) phosphatases II 818-1026 7.6e-27 89.8 In-house 59-277 (284) alignment
Range on Protein: 818-1026
Range on HMM: 59-277/284.0
MFTAHYLDGY-----WTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFgTTGLKFGAITISVGRKKEfNAGFLTRDINIR
 . | |.|||     .... ||    |.....| |||.. ......|. | ... .     . | ..   . |..| .|. . .... . .. .| . ..
YinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtlelt

NEE-DSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVEScHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKER---IINILQAANHHYLQSP
|.. ..  ..|....| .    |. |  .. ...|....  . |. ..|..||. |. .  |  | |..| ..|.. .||.    ...|.| ..   | |
nlgytgesrtvthfhytswp.dhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp

GLIVNLQFYAYCYDCLMEYSNKL
| . .|. | ..|..|.|| ...
gmvqtleqyrfvyealleylklk

0042113 (Phosphotyrosine protein) phosphatases II 818-1023 1.5e-25 85.5 In-house 39-243 (245) alignment
Range on Protein: 818-1023
Range on HMM: 39-243/245.0
MFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEEDS
   | | |||. .. || . .|.....| |||.. . ....|..|....     . . | ..   . |..| .|. . . .  .... .| ... |. |.
yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.lddytvrtlevtnlgdd

MLLRVKYIQYQDMFlKHCFPR-VDKFMKFIQYCLVQVESchHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
  . |  ..| ..   |. |  .. . .|..... ....  ..|.|.| |  .  |  | |... ..|....||. ... .|  .   | || . ....|
esrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy

AYCYDCLMEYS
 ..|..|.|. 
rflyeallell

subfamily_PTPRK_pd Subfamily PTPRK 818-1021 6.2e-16 53.1 In-house 73-275 (314) alignment
Range on Protein: 818-1021
Range on HMM: 73-275/314.0
MFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADT-YSYISEFGTTGLKFGAITISVGrKKEFNAGFLTRDINIRN--EEDSM
   | ..|.|  |. ||    | .. .. ||||. ...|. |. |.   . . .  .  .   . ..| | . .  . | .| ...|  ....     . 
yinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelv.etellaelvvrifrveklargqee

LLRVKYIQYQDmFLKHCFPRV-DKFMKFIQYCLVQVESchhGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYA
   |. .|.   . .|  |     ..|...    . |    .. .|..|     |  |.| ...  |. ...|..... .|.     . . ..   . | 
irevrqfqflg.WpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqyk

YCYDCLME
..|| ..|
fiydvile

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 818-1027 2.7e-08 28.2 In-house 59-272 (274) alignment
Range on Protein: 818-1027
Range on HMM: 59-272/274.0
MFTAHYLDGYW-TPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTT--GLKFGAITISVGRKKEFNaGFLTRDINIRNE
   | |. ||  . . ..    |     . |||.| ..... |. |             |  .   .    ..| . | |  ..| | ..  | . ... 
yinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekivern.dysvrklvlkyl

EDsmLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.    .||.. | |   ..   ..........    . |. ..   |...|     |  |.| . . .... ..| ....|.   .  |.  |.. . .
er..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtse

FYAYCYDCLMEYSNKLL
 | . .  |..| ..||
qyelihralclylkrll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 818-1027 9.5e-08 26.3 In-house 50-268 (270) alignment
Range on Protein: 818-1027
Range on HMM: 50-268/270.0
MFTAHYLDGYW-TPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTY----SYISEF--GTTGLKFGAITISVGrKKEFNAGFLTRDINIRne
 . | |. |.   .. .| .  |..  .. |||.|...| . |. ...   .       | ..    .. |..| |.. .  ..| . |.... ....  
YinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlal.seekeegyiltrlrle..

EDSMLLRVKYIQYQDmFLKHCFPRVDK-------FMKFIQYCLVQVESCHHGNhPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSP
|..   |.   .|.. .  |  || .         .| ..    . .. .... |.|.|.    |  |.. .| ....  .... ...|.  ..   . .
ekgeerrlvHfwynt.Wpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRm

GLIVNLQFYAYCYDCLMEYSNKLL
 |.   . |.. |  ..|| ....
alvqhpeqyeflykavveyaerra

0040438 (Phosphotyrosine protein) phosphatases II 819-1039 1.6e-27 92.1 In-house 74-292 (317) alignment
Range on Protein: 819-1039
Range on HMM: 74-292/317.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEEDSM
  | | ||.. .. ||    |... .| |||.. . ....|..| ... .     . | ..   . |..| .|. .   .| .||.  | . . . .|| 
InAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdse

LLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAY
 ..|. ..| .    .. |  | . .|....  . |   ....|.| |  .  |  | |... ..|.. .||. ... .| ..   | || . ....| .
srtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrf

CYDCLMEYSNKLLKEEYFPSIHENI
.||.|.|| .. |. |.... .  .
lydalleylkrkltlepaselklkl

Y_phosphatase Protein-tyrosine phosphatase 819-1021 1.1e-23 79.3 Pfam-A 30-235 (235) alignment
Range on Protein: 819-1021
Range on HMM: 30-235/235.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVG-RKKEFNAGFLTRDINIRNEEDS
  | |..||.... || . .|.|.  | |||.....|.. |. |   .      .  | .|   . |..| |.. .  ..|| .... .|..........
InAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkee

-MLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVescHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
    .|| ..|..   .|. |  .......|. .  .    .. ..|.. |     |  |.|..| ..|.....|. ...||. ..   | ||.. .|. 
sekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

YAYCYDCLME
|...|....|
Yiflykaile

Y_phosphatase Protein-tyrosine phosphatase 819-1021 1.1e-23 79.3 In-house 30-235 (235) alignment
Range on Protein: 819-1021
Range on HMM: 30-235/235.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVG-RKKEFNAGFLTRDINIRNEEDS
  | |..||.... || . .|.|.  | |||.....|.. |. |   .      .  | .|   . |..| |.. .  ..|| .... .|..........
InAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkee

-MLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVescHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
    .|| ..|..   .|. |  .......|. .  .    .. ..|.. |     |  |.|..| ..|.....|. ...||. ..   | ||.. .|. 
sekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

YAYCYDCLME
|...|....|
Yiflykaile

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 819-1022 1.1e-18 62.5 In-house 87-289 (298) alignment
Range on Protein: 819-1022
Range on HMM: 87-289/298.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA-DTYSYISEFGT-TGLKFGAITISVGRKKEFnAGFLTRDINIRNEEDSMLL
  | .|..|   | || .  | .  .| |||...... . |. | ..   |.  |   . .    ..| ||.|. .|.|| | . .| ... ... .   
iNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeef.adlivrklkvskkkeeker

RVKYIQYQDmFLKHCFPRVD-KFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYC
.|. ...   .  .. |..    .....   |.    . ||.|....     |  | |  .   |.|.|||. . ..|. .    . ||..   . |...
evrqlhfts.Wpdkgvpenatsvldllrk..vrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

YDCLMEY
|.  .|.
yeavlea

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 819-1021 2.6e-16 54.4 In-house 80-277 (315) alignment
Range on Protein: 819-1021
Range on HMM: 80-277/315.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYIS-EFGTTGLKFGAITISVgRKKEFNAGFLTRDINIRNEED-SMLL
  | ..|||  .. .| .  |     . ||||. ......|. |. .  .  .     .    . .| ||..  ...| |  .  | . .  ...   ..
vnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtr.kseevnteytvrtlsvvfgdnirevv

RVKYIQYQDMFLKHcfpRVDKFMKFIQYCLVQVESCHhgnHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCY
...|  . || . .       .|..|.   .  ..      .|..| .   |  | | ||   |..|. |..|.. .. .    .  ...  .. | . |
qlhytswpdmgvpk...ytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiy

DCLME
| |.|
dalle

subfamily_Ptp69D_pd Subfamily Ptp69D 819-1025 3.4e-15 51.0 In-house 79-288 (307) alignment
Range on Protein: 819-1025
Range on HMM: 79-288/307.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGT--TGLKFGAITISVGRkKEFNAGFLTRDINIRNEEDS---
  | .. ||   . || .  |     . |||.|  ..   |. ||  .  .   .. . .  .  ..| | . . . .|.   .  |.... . ...   
inasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvs.eekhsdyiiReldvskkkeesge

MLLRVKYIQYQDMFL-KHCFPRV-DKFMKFIQYC--LVQVEschhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
.  . | .||. .       |.|    .|.|.    | . .     . ||..|     |  ||| .|.  ||. |.|  ..| .   .   | . |. .|
vedsrkvvqyhytgWkDskvPevargllklieqvrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl

QFYAYCYDCLMEYSNK
. | ..|  |..||..
eqYvflyralldyssy

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 819-1023 6e-15 50.0 In-house 74-278 (287) alignment
Range on Protein: 819-1023
Range on HMM: 74-278/287.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEFGTtgLKFGAITISVGRKKeFNAGFLTRDINIRNEE-DS
  | ..|||   . || .  |  .    ||.|| ... . |. |.     ..   | | .|  .  . .|  .|..  ..  |||.. |.....|.. ..
inavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkag

MLLRVKyiQYQDMFL--KHCFPRVDKFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
  ..||  |||      .   ..    .  |.      .  ..|| .|..|   . |  ..|      ....|.| .|...|  ..   | || .   . 
dkqqvk..qyqitnWdstgkvtepqtillviee..myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

YAYCYDCLMEYS
| . .| ..|| 
ykfindivleyl

0036282 (Phosphotyrosine protein) phosphatases II 819-1017 9.9e-14 46.9 In-house 5-164 (174) alignment
Range on Protein: 819-1017
Range on HMM: 5-164/174.0
FTAHYLDGYWTPNLFIKSPCPTKdntecFWRLIIHKKCSHIINLSPTDADTYSYISEFGTTglkfgaitisvgrkkefnagfltrdinIRNEEDSMLLRV
. | .||... .. .| . .|..     ||... . .......| .   . .  .  .  .                            |. .  . ...
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlgiqy

KYIQYQDMFLKHCFPrVDKFMKFIQYCLVQveschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKkERIINILQAANHHYLQSPGLIVNLQFYAYCYD
.|.   |.        ...|.||.. .| .     ....|.| |  .  |  |... . ..|.. . |. ...|.      || || . . ..| ..|.
lylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

subfamily_PTPN9_pd Subfamily PTPN9 819-1025 1.3e-11 39.0 In-house 73-292 (297) alignment
Range on Protein: 819-1025
Range on HMM: 73-292/297.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVGRKkEFNAGFLTRDINIRN---EE
  | ..|||  .. ||    | |  .. |||..  ...  |.    .          |  .   .  .|| ...|.    | .  . .| ..|.|   ||
inanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvev.eeeedykvrvleiknvktee

DSMLLRVKYIQYQDMFLKHCFPRVDKFMK---FIQYCLVQ----VESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPG
   .   ... . |    .    . ....     | ..|.     .  |  . ||..|     |  | |.|| .||.| ...  ... .. ..   |   
srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqraf

LIVNLQFYAYCYDCLMEYSNK
 |   . |..|| ...||. .
siqtpeqyefcylavleyale

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 819-1022 8.8e-11 36.1 In-house 68-276 (287) alignment
Range on Protein: 819-1022
Range on HMM: 68-276/287.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINL----SPTDADTYSYISEFgTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSM
  | |. .|   . || .  |       |||...... . .| .      .   .| |  |     .. |  .. .  ..  .  . .| . . . |   
inanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletre

LLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESCHHGN--HPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
   || ... ..  |   |    ...|.  .  ..|    ..   |...|||   |  ||. ..  ...| ..   ... ..  .   .  .|.     .
arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvql

AYCYDCLMEY
 . |. |. |
rllyealvty

subfamily_PTPN12_pd Subfamily PTPN12 819-1028 1.2e-09 32.4 In-house 71-282 (290) alignment
Range on Protein: 819-1028
Range on HMM: 71-282/290.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLS----PTDADTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSM
  | .. |   .  .| .  |  .  . |||.|..|. . .. .             | .| | . |.||...... ..| .. .|| | ........| 
inanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr

llRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERI---INILQAANHHYLQSPGLIVNLQF
  .|. ..|..   . .  .... ...|.      |   . ..|...|     |  |.  .. |  .  |.|.|   ... .   .   | . |.   . 
..kvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq

YAYCYDCLMEYSNKLLK
| . | ...|. .| |.
yelvykavaelvqkele

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 819-1018 2.5e-08 28.4 In-house 32-234 (237) alignment
Range on Protein: 819-1018
Range on HMM: 32-234/237.0
FTAHYLDGY-WTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEFGtTGLKFGAITISVGRKKEFnAGFLTRDINIRNEEDS
  | ||.|.  ||. .| .  | .   . ||...  .||| |. |.      .   . |  .       .| .|.|. .|.|| . .  | . . ..   
inatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvltvslkkkeef.sdytvrslllskrltl

MLLRVKYiQYQ-DMFLKHCFPRVDK-FMKFIQYcLVQvESCH-HGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
  .|. . |||   . ..  |.    ...| .  ... .| |     | ..|     |  |||  .   |..||......| .       . | .|   .
kevrlih.qyqftswpdrgvpqqtaallrfrkn.iin.rsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

FYAYCYDC
 | . .. 
qyvfihqt

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 820-1023 5.3e-19 63.4 In-house 78-280 (318) alignment
Range on Protein: 820-1023
Range on HMM: 78-280/318.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEF--GTTGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLR
 | |.|||   . .| .  |  .  | |||..  .... |. |. .   .   .  .  .    ..|.... .  ..|..  .. | ......| .    
nanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsd.yvlrefkvtrteeeesrq

VKYIQYQDMFLKHCFPRVDKFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
|.  .| .   .     . .......   |.    ..|..||..|  .  |  |.| ..   |.|.|.| .....|  ..   | . ..   . | ..||
vrqyhytsWpdegvpesgaslldlvrq..vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd

CLMEYS
 |.|. 
vlleal

subfamily_CG7180_pd Subfamily CG7180 820-1022 7.5e-18 59.2 In-house 74-289 (296) alignment
Range on Protein: 820-1022
Range on HMM: 74-289/296.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGTT-GLKFGAITISVGRKKEFNAgFLTRDINIRNE--------
 | | |..  .. .|    |.|.  . ||||.  ...| ...|. |   .  | | .  .   ..| | . . ..|.. . . .| . .  .        
navyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyan.lkirtfkltkkivalteqe

--EDSMLLRVKYIQYQDMFLKHCFPRV-DKFMKFIQYCLVQVESC--HHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGL
  ..     || .|..   |.. .| .   ......   . .|    .  . |....     .  |.. ..  .|. ..||  ... .|.     . |.|
kqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqL

IVNLQFYAYCYDCLMEY
. | . | |.|| | |.
venveeYkyiYdvllea

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 820-1024 2.2e-16 54.8 In-house 41-243 (250) alignment
Range on Protein: 820-1024
Range on HMM: 41-243/250.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFG-TTGLKFGAITISVGRKKEFnAGFLTRDINIRNEEDSMLLRV
 | .|.||   ..|| .  | .. .| |||.....| . |. |.        |   .   .  |.| .|.|.  |.|| | . .| . . ... .    |
nasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeef.adytkrklklskakkaderiv

KYIQYQDmFLKHCFPRVDK-FMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
. ...   .   . |.| .  .....   || .  . || |....     |  | | ..   |.|.|||..... .  .    . |. .  |. | ..| 
rqlhfvv.WPdkgvPevatavLellkk..vqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvye

CLMEYSN
 .... .
iilkald

subfamily_PTPRG_pd Subfamily PTPRG 820-1022 3e-16 53.8 In-house 80-286 (563) alignment
Range on Protein: 820-1022
Range on HMM: 80-286/563.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRN-----E
 | |.|||   . || .  | || ...|||.|  .. . |. ..     .  .   |  .   . ...||...   ...   |   .| . |.|     .
nAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev.lalytvrtlviknlklkkk

ED-SMLLRVKYIQYQDmFLKHCFPRVDKFMkfIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
..    ..|.  .| . .  |. |    .   ...   .  . ..   ||..|..   |  |..  |.  |.. ..| ..|... . |  .| . |. . 
kqcdteklvrqyhytk.WPdhgvPehslpv..LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte

QFYAYCYDCLMEY
  | . .| |.| 
EqYiflhdallea

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 820-1021 5.6e-16 53.9 In-house 57-253 (284) alignment
Range on Protein: 820-1021
Range on HMM: 57-253/284.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSptDADTYSYISEFGttGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLRvK
 | .. ||  .. .| .  | ..  . |||.|   .|| |. |.  .     |    .    | .   ..|   .| .  .  |||.. ..      | |
nasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplki..vikeerfkvkvdsveesee.yvvrdielsedgkekdir.k

YIQYQD-MFLKHCFPRVDK-FMKFIQYcLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
  |.    . ..  |     .|....  .  ..| ......|..|     |  |.. .|   |.| |.|. ... .  .    | . |. .|  | ..| 
irqfhflgwpdvgvpdypsdlmrlvkk.vrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLME
 |.|
alle

subfamily_PTPRA_pd Subfamily PTPRA 820-1023 5.9e-16 53.3 In-house 90-295 (330) alignment
Range on Protein: 820-1023
Range on HMM: 90-295/330.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEFGTtgLKFGAITISVGRKKEfNAGFLTRDINIRNEEDSML
 | ..|||   . || .  | ..  | |||.|  .| . |. |.  .       . |  . |.  . .| |...|  ...    .  |.. ...  |.. 
nasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetv.lvdytvrkflvqqlpdatr

LRVKYIQYQdmFLKHCFPRV-----DK-FMKFIQycLVQVESCHHGNhPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
 . . .  |  |  . .| |      .  .|...   |.     ... || .|     |  | | .|   |.| | ||.... .. ..  || | ..  .
ekksrlvrq..fhftswPdvGvPfepiGmlkllk..kvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd

QFYAYCYDCLMEYS
. | ..|  |.|| 
eqyefiykvlleyy

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 820-1021 9.1e-16 53.0 In-house 93-289 (319) alignment
Range on Protein: 820-1021
Range on HMM: 93-289/319.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSptDADTYSYISEFGttGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLRvK
 | ...||  .. .| .  | ..  . |||.|   .|| |. |.        |    .    | .   ..|   .| .  .  |||.. ..      | |
nasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplki..vikeerfkvkvdsveetae.yvvrdielsedgkekdir.k

YIQYQD-MFLKHCFPRVDK-FMKFIQYcLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
  |.    . ..  |     .|....  .  ..|  .....|..|     |  |.. .|   |.| |.|. ... .  .    | . |. .|  | ..| 
itqfhflGwpdvGvpdypsdlmrlvkk.vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLME
 |.|
alle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 820-1025 1.3e-15 52.1 In-house 80-285 (290) alignment
Range on Protein: 820-1025
Range on HMM: 80-285/290.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT----DADTYSYISEFGTTGlkFGAITISVGRKKEFNaGFLTRDINIRNEEDSmL
 | |..||   . .|    |...    ||.|| ..|.. |. |           . | .. .|.   .| ..| .   ...| .. .| ....|.. .  
nAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetln.eyierklevknknsa.g

LRVKYIQYQ--DMFLKHCFPRVDKFMKFIQycLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYA
 . . .|||   .  .   .     .  |.   ..    ..||..|..|  .. |  ..| ...  ....|.|  |...|  ..   | ||..   | | 
akqsvtqyqitnwdstgkvtnpqtillvie..emyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq

YCYDCLMEYSNK
. .. ...| ..
gifqivltylds

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 820-1023 1e-14 49.3 In-house 79-279 (288) alignment
Range on Protein: 820-1023
Range on HMM: 79-279/288.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT----DADTYSYISEfGTTGLKFGAITISVGRKKEFNAgFLTRDINIRneEDSML
 | |.||.   . .| . .|  |  . ||.|.  .| | |. |.      .     |  . . .  ..| .|. .  .|| .  |..| . .    .   
nasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeled.fvlrkllle..kkkte

LRVKYIQYQdMFLKHCFPRVDkfMKFIQYcLVQVESCHHGN-HPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAY
|...  ||. ..  |  |.    . .... | ||.  .. .  ||..|     |  |.| .|   ... ..|  |... . ..   | . |. .|. | .
leitqyqyl.aWpdhgvPesk..apllel.lrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYef

CYDCLMEYS
.|..|..  
iyevllsli

subfamily_PTPRB_pd Subfamily PTPRB 820-1024 1.5e-13 45.4 In-house 83-286 (293) alignment
Range on Protein: 820-1024
Range on HMM: 83-286/293.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFG---TTGLKFGAITISVGRKKEFNaGFLTRDINIRNEEDSMll
 | |..||..|. || .  |  . .. |||..  ||.| |. |  .         |.    ..   .| |....  ..| .  . .|...|..|....  
nanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeele.dwvirelkiekekeer..

RVKYIQYQdMFLKHCFPRV-DKFMKFIQYCLvQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYC
.|.  ...  .  |  |   .....|..    .. . .. ..||..|     |  |.| .|   ||. ..| ...|.    .   .   |. . . | . 
kvrqyhft.sWpdhgvPektktlldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi

YDCLMEYSN
..|.... .
hqcvldllr

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 820-1027 2.7e-09 31.6 In-house 73-280 (281) alignment
Range on Protein: 820-1027
Range on HMM: 73-280/281.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEfGTTGLKFGAITISVGRKKEfNAGFLTRDINIrNEEDSML
 | ...||  .. .| .  |  .  . ||.... .| | |. .           . |  . ... ||.| .|..  ...| .| ...| ... ..|..  
nanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPd.dnselkygdvtvkstaeee.katyierkfkl.eresget

LRVKYIQYQDmFLKHCFPRVDkfMKFIQYCL-VQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKE-RIINIlQAANHHYLQSPGLIVN-LQFY
 .|. ..|.  .  |  |     ......   |.  . .. ..|...|     |  | . .|   ......| . ... .|  ..  ..  |.|  .  |
reveqlayta.WPdhGvPatt..kellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldv.kavvaelrkernlmvqtvvqy

AYCYDCLMEYSNKLL
.. |  .... .| |
efvykavldaldkel

DSPc_SM00195 821-1022 2.6e-21 71.5 In-house 59-261 (263) alignment
Range on Protein: 821-1022
Range on HMM: 59-261/263.0
AHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSMLL
| |..|.. .. .|    |...  | |||.....|.. |. |.  .       ..|  |   .  .|| |.. . .... .. . .|......|...   
AnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetr

RVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCY
.|. .||..   . .    ..........  . ..    ..||. | .   |  |.|.|. ..|.. ..|  ..| .  ..   | ||.. .|..|...|
kvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy

DCLMEY
....||
eailey

PTPc_SM00194 821-1022 2.6e-21 71.5 In-house 59-261 (263) alignment
Range on Protein: 821-1022
Range on HMM: 59-261/263.0
AHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSMLL
| |..|.. .. .|    |...  | |||.....|.. |. |.  .       ..|  |   .  .|| |.. . .... .. . .|......|...   
AnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetr

RVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCY
.|. .||..   . .    ..........  . ..    ..||. | .   |  |.|.|. ..|.. ..|  ..| .  ..   | ||.. .|..|...|
kvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy

DCLMEY
....||
eailey

0045098 (Phosphotyrosine protein) phosphatases II 821-1024 1.9e-18 62.3 In-house 56-273 (278) alignment
Range on Protein: 821-1024
Range on HMM: 56-273/278.0
AHYLDGYwtPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADT----YSYISEfgTTGLKFGAITISVGRKKEFnAGFLTRDINIRNE----ED
| |.|||  |. ||    |...... |||.. . ....|..| .   ..    . |  |     | .| .|. .   ...   . .|.....|     ||
Asyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevl.ddytlrtllvtnltvered

SMLLRVKYIQYQDMFLKHCFPRV--DKFMKFIQYCLVQVE----------SCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAkkERIINILQAANHHYL
 . . |....|  .   .. .    . | .......  ..          ... ...|.| |     |  | .. . ..|..   |. ...|.| ..   
lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrs

QSPG-LIVNLQFYAYCYDCLMEYSN
| ||  . ||..| ..|..|.|. .
qRpglavqnleqyrflyefllelll

subfamily_PTPRD_pd Subfamily PTPRD 821-1025 5.5e-18 59.9 In-house 81-283 (564) alignment
Range on Protein: 821-1025
Range on HMM: 81-283/564.0
AHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEF-GTT-GLKFGAITISVGRKKEFnAGFLTRDINIRNEEDSMLLRV
| ..||| ... .| .  |... .| |||..  ...| |. |. .   .   ....  ..   ..| .|...  ..|. | .  |.........|    |
AsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeel.adyeirtfklkkkkssesreV

KYIQYQDmFLKHCFP-RVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
.  .. .    |. |    .....|. .    |   ....||. |     |  |.| .. ..|.|.|.|. ..| |  ..   | . .. . . |.....
rqFhFts.WPdhgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFihe

CLMEYSNK
 ..|. ..
ailealac

0051429 (Phosphotyrosine protein) phosphatases II 821-1027 4e-14 48.4 In-house 9-229 (272) alignment
Range on Protein: 821-1027
Range on HMM: 9-229/272.0
AHYLDGYWT---PNLFIKSPCPTKDNTECFWRLiIHKKCSHIINLSPTD----ADTYSYIS----------EFGTTGLKFGAITISVGRKKEFNAGFLTR
| ...||.    |.... |..|.. . . ||||  . ....|..| ...     ... |.           .....   .||... .  .. ..   |..
ardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilre

DINIRNEEDSMLLRVKYIQYQDMFLKHCFPRVdkFMKFIQYCLVqveschhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIIN--------ILQAA
 . ..    .. ..|  ..|.|.   .  .    . ......|         ..|.|.|  .  .  |... | ..|..  .| |..        ...| 
llltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

NHHYLQSPGLIVNLQFYAYCYDCLMEYSNKLL
..   | || . . ..|...|..|.|. ..||
eelraqrpgavqteeqylflyeallellrsll

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 821-1022 1.1e-12 42.7 In-house 84-283 (297) alignment
Range on Protein: 821-1022
Range on HMM: 84-283/297.0
AHYLDGYWTpnLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA---DTYSYISEFGTTGlkFGAITISVGRKKEfNAGFLTRDINIRNEEDSMLLR
| .. |.     .| .  | |.  . ||....... | |. |.  .        | |. |.|   || ... .   .|   ||. |........  .   
asfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt..fGdvsvvllsvse.reGfikrelevtkgkakarrv

VKYIQYQDMFLKhCFPRVDKFMKFIQYcLVQVESCHHGN-H-PILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYC
||  |. .   |   .| |.  ..... . .|.  . .| . |.|.|     |  |.. |.  .. .||.|  ..|..  ..   . | |.   . |.. 
vkqyqfveWPdk.averkdsassllkl.isevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

YDCLMEY
|  ..|.
yvavlea

0051082 (Phosphotyrosine protein) phosphatases II 821-1019 6.7e-09 31.0 In-house 8-149 (151) alignment
Range on Protein: 821-1019
Range on HMM: 8-149/151.0
AHYLDGYwtpnlFIKSPCPtkdnTECFWRLIIHKKCSHIINLSPTDADTySYISEFGTTGlkfgaitisvgrkkefnagfltrdinirneedsmlLRVKY
..|..|.     .. | .|    .. |..|. . ....|.|| ...     . . .  .|                                   ..|..
fsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................ievlh

IQYQDMFLKHCFPRVDKFMKFIQYCLVqveschHGNHPILMHDDGSNGPIGIFATLTYCLQRakkeriINILQAANHHYLQSPGLIVNLQFYAYCYDCL
|.. |.    .    | ...|....|       ..|.|.|.|  .  |  |... |  .|..      ... .| ..  |. ||..   | . ... .|
ipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 823-1020 2.5e-10 34.3 In-house 228-435 (440) alignment
Range on Protein: 823-1020
Range on HMM: 228-435/440.0
YLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGTTGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLRVKYIQ
 ..||   | || .  |       ||||.   . | || |   .  | |      |  . || .|.     ...|     | ....  |.   .|   .|
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkykeevheirqfevq

-------YQDMF-LKHCFPRVDKFMKFIQYCLVQV--ESCHHGN-HPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
        . .   . |.  | ..| ... | .|   |    |.  |||.|        |.| |.  ||.. ...  |...|      |  | ..  |  
twptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltd

YAYCYDCLM
|  ||  | 
yllcykllt

0049260 (Phosphotyrosine protein) phosphatases II 823-1017 7.6e-08 27.7 In-house 1-144 (152) alignment
Range on Protein: 823-1017
Range on HMM: 1-144/152.0
YLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGttglkfgaitisvgrkkefnagfltrdinirneedsmllRVKYIQ
..|||. |. ||    |.  ... |||.. . ....|..|   . ... .  .                                         ......
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlp

YQDMFLKHCFPRVDKFMKFIQYClvqvesCHHGNHPILMHDDGSNGPIGIFATLTYCLqrakkeRIINILQAANHHYLQSPGLIVNLQFYAYCYD
  |.        .. ...||. .      ... ..|.| |  .  |  | .. . ..|      . .....| ..   . || . | ... ..|.
wpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

0046846 (Phosphotyrosine protein) phosphatases II 825-1024 2e-08 29.7 In-house 17-174 (176) alignment
Range on Protein: 825-1024
Range on HMM: 17-174/176.0
DGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD-------ADTYSYISEFGTtglkfgaitisvgrkkefnagfltrdinirneedsmllR
....  ...|    |. .... |.... . ......||           .. .... ..|                                       .
anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................................q

VKYIQYQDMFLKHCfPRVDKFMKFIQYCLVQveschhgNHPILMHDDGSNGPIGIFATLTyclqRAKKERIINILQAANHHYLQSP-GLIVNLQFYAYCY
....   |.        ......||. .| .       ..|.| |  .  |  | .. .       ..|. .....|  .   | | | . . ..| ..|
ylhlpwpDhgvpdl.elllellefirealke.......ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfly

DCLMEYSN
...... .
efellllk

0044763 (Phosphotyrosine protein) phosphatases II 830-1022 8e-07 24.4 In-house 28-170 (178) alignment
Range on Protein: 830-1022
Range on HMM: 28-170/178.0
PNlFIKSPCPTkdntECFWRLIIHKKCSHIINLSPTDA------DTYSYISEFgttglkfgaitisvgrkkefnagfltrdinirneedsmlLRVKYIQY
|. .. ...|.    .....|.   ...||.||....       | | . ..                                        .....| .
pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipi

QDMFLKHCFPRVDKFMKFIQYCLvqvescHHGNHPILMHDDGSNGPIGIFATLTYCLQRakkeRIiNILQAANHHYLQSPgLIVNLQFYAYCYDCLMEY
 |.     .  ...|..||. .|      .  ..|.| |     |  | .. . .....    .. .. .| ..   . |  . |  .. ..|.. ...
pDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 831-1021 2.1e-14 48.1 In-house 75-264 (283) alignment
Range on Protein: 831-1021
Range on HMM: 75-264/283.0
NLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGT--TGLKFGAITISVgRKKEFNAGFLTRDINIRNE--EDSMLLrVKYIQYQDM
. .| .  | ..    ||... ..| . |. |..   |     | .       ..|  |... ||   .  |  . . .|..    | || . . |..| 
kkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtl.rkettsnsfiikelllrvnssakstll.lahyqvidW

FLKHCFPRVDKFMKFiqyCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLME
      . .. ..||    .|.    .. . ||..|     |  ..| ...  .. |. | .... .  .    | .... .|. |   ..  .|
leygeqaiinslvkf...nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_PTPN3_pd Subfamily PTPN3 831-1024 5.8e-12 40.1 In-house 84-276 (280) alignment
Range on Protein: 831-1024
Range on HMM: 84-276/280.0
NLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEfGTTGLKFGAITISVGRKkEFNAGFLTRDINIRNEEDSMLLRVKYIQYQDm
| .| .  | .. .. ||... ..|.| |. |  .        . |  |  .  |..| ... . .. . .  ...|.. ....| .   ..  .|| . 
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqyla.

FLKHCFPRVD-KFMKFIQyclvQVESCHH-GNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSN
.  |. |    .|..|..    .|.....  ..|...|  .  |  |.. .|  .|.   ... ...|.   .   |   |. . . | .  ..... ..
WpdhgvPddsadflefve....rvrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye





subfamily_PTPN23_pd Subfamily PTPN23 833-1027 5.3e-09 30.3 In-house 85-284 (288) alignment
Range on Protein: 833-1027
Range on HMM: 85-284/288.0
FIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADT----YSYISEFGTTGLKFGAITISVGRKKEFNaGFLTRDINIRNEEDSMLLRVKYIQYQDmFL
|| .  | .     ||... ..| | |. |   ..       .|  |      |||...... ...| .  .  |..... .. .    |...|..  . 
fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqlts.Wp

KHCFPR-VDKFMKFIQYCLVQ-VESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRA-KKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNK
..  |   .....|..    .  .  .. . |...|     |  |.|| .   ..   |.. ...|.|  ..   |    . . . .  .|.  .|. ..
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

LL
 |
vl

subfamily_PTPN14_pd Subfamily PTPN14 833-1024 1.2e-06 22.7 In-house 95-297 (300) alignment
Range on Protein: 833-1024
Range on HMM: 95-297/300.0
FIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT----DADTYSYISEF--GTTGLKFGAITISVGRKkEFNAGFLTRDINIRNEEDSMLLRVKYIQYQDM
.| .  | .   . ||...  .. . |. |  .       ...|. .       ..||   ..   . |    . |. ....    .    | ..||.| 
yivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs.edsdsvittglklkhlpskeertvwhlqytDW

FLKHCFPRVDKFMKFIQYC------LVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLM
  ... . |..|.....          .  . .. . |.|.|     |  |.  .    ..  .... |.| .. ..   |   |. .|  | . |. |.
pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

EYSN
.| .
kylk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 879-1040 1.2e-103 342.0 In-house 277-439 (439) alignment
Range on Protein: 879-1040
Range on HMM: 277-439/439.0
TGLKFGAITISVGR-KKEFNAGFLTRDINIRNEEDSMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLT
  ...|.|...... ||||||||.||||.|.|||||.||..||||||.|.||.||||||||.||||.|||.|||||.||||||.||||||||.||||||.
edivyGdiavtidefkkefnagfstrdisifneedssllklkyiqyqemllkqcfprvdkfikfiqgclveveschrgnhpilihddgsngpvgifatla

YCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNKLLKEEYFPSIHENIA
||||||||||||..||.|||||||||||||||||||||||||.|||.||||||..|||.||||
yclqrakkeriidllqsanhhylqspglivnlqfyaycydclleysdkllkeeslpsiyenia

subfamily_PTPN13_pd Subfamily PTPN13 881-1022 7.7e-06 20.4 In-house 131-268 (273) alignment
Range on Protein: 881-1022
Range on HMM: 131-268/273.0
LKFGA-ITISVGRKKEFnAGFLTRDINIRNEEDSMLLRVKYIQYQDmFLKHCFPRVD-KFMKFIQYclvqVESCHHGNHPILMHDDGSNGPIGIFATLTY
||    ..... . ..   ||  |...... | .   .|  ... . .  |  |.   ....|...    | . .. . ||..|     |  |.. |.  
lkvsnrlevellkvqkl.dgfvvralavkdsesgesrevahlnfvk.wPdhgvPssaaellqfvae....vrrlqtdagPivvhcsaGiGrsGtlitidv

CLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEY
 |.  .... ... .  ..   |  |..   . | ..|  ..| 
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

PTPc_DSPc_SM00012 918-1021 2e-07 26.5 In-house 5-105 (105) alignment
Range on Protein: 918-1021
Range on HMM: 5-105/105.0
VKYIQYQDMflkhCFP-RVDKFMKFIQYCLVQVESCHHgNHPILMHDDGSNGPIGIFATLTYCLQRAKKE-RIINILQAANHHYLQSPGLIVNLQFYAYC
..| ...|.    . | ..|.........  . . . . ..|.. |.    |  |.|..| ..||. .|| . ..|.|  ..   | ||.. ... | ..
yhytgwpdh....gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDCLME
|..|.|
yralle