Gene PTPRD-51 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP108_AA protein Get Run
AqueP108_AA_5-232 phosphatase_domain Get Run
AqueP108_AA_244-510 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-251 4.3e-114 375.8 In-house 57-303 (305) alignment 
Range on Protein: 4-251
Range on HMM: 57-303/305.0
TDDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN
..||.|| ||. ..||  .. | ||||.|||... |.|..|||.|.|..||||||..||...|||.|.|.|| |.||.||||....|. .||.|.|.|..
lldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelks

EQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
|. ..|...|.|.. | |....|.|..||.||.|||||||..|| |.|| |.|. ... .|| |.||||||||||||.|||.|||||..|.|.|||....
ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfev

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELK
...||..|||||||||||||||||. | . ||||.|. . ...... ||
lkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-229 3.3e-59 194.9 In-house 18-238 (239) alignment 
Range on Protein: 4-229
Range on HMM: 18-238/239.0
TDDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNfgpFTVTLT
| | .|.||      .  .. | ||||.  |    | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.. ..  |   . ||| 
tydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn...lrvtlr

NEQVYPDFVIRQLNVKiYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
. .|. |..|| . .    |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |||..  |||   
ktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

VNRLRQQRMKMVQTLDQYVFLHDAVLE
|. .|..| .|||| .||||.| ||||
vkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4-229 6.2e-59 194.0 In-house 19-239 (239) alignment 
Range on Protein: 4-229
Range on HMM: 19-239/239.0
TDDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNfgpFTVTLT
| | .|.||      .  .. | ||||.  |    | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.. ..  |   . ||| 
tydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn...lrvtlr

NEQVYPDFVIRQLNVKiYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
. .|. |..|| . .    |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |||..  |||   
ktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

VNRLRQQRMKMVQTLDQYVFLHDAVLE
|. .|..| .|||| .||||.| ||||
vkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 5-237 6e-112 368.2 In-house 52-299 (301) alignment 
Range on Protein: 5-237
Range on HMM: 52-299/301.0
DDDNRIVLTPWPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNE
 |||||.|.|.|.||.||..|.|||||||||...||||.|||||||||||||||||||||||||||||||||||||||||||. ||...||||||||.||
yddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvne

QVYPDFVIRQLNVKIYDGSN--------------DSHTLTQYHLTSWPDHGV-PDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALE
|||||||||||||||.||||              .|....|...|.||..|| ....| |...............||..||||..|.|.|......|.||
qvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglE

QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTE
|.|.|||||. ......|......|.||.||....|.. ..... .|.
QckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-233 7.3e-84 276.1 In-house 58-285 (290) alignment 
Range on Protein: 5-233
Range on HMM: 58-285/290.0
DDDNRIVLTPWPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENynFGPFTVTLTNE
 |||||.| | ..   |.  | ||.||.||... ..|| |||...||||||.||||||   |||.|| .|  | || ||||.. ...  .|.|...|.||
yddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllne

QVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
... ....|.|.||  . .......|||..|.|...| |....| |.......   . . ...|.||||..|||...|.|........| |||.|.  ..
etlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvl

NRLRQQRMKMVQTLDQYVFLHDAVLETVMC
...|.|....||| .|| .... ||. . .
ksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-237 7.2e-83 272.9 In-house 59-284 (287) alignment 
Range on Protein: 5-237
Range on HMM: 59-284/287.0
DDDNRIVLTpwpqldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAenYNFGPFTVTLTNE
 |..|..|       ...  | ||..||||... .||....|| .|...||.||.....  |||....|| ....| ||||.. .    .|.....|.||
pdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellne

QVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.|. ....|.|.||  . ..| ....||..|.|...| |....| |. ..... .   .....|.||||..|||...|.|........|.|||.|.  ..
evnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvl

NRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTE
.. |.|....||| .|| |. |.||| . ...| 
ksqriqkpgsvqtveqykfindivleyldsfety
subfamily_PTPN23_pd Subfamily PTPN23 5-231 3.1e-54 178.7 In-house 55-280 (288) alignment 
Range on Protein: 5-231
Range on HMM: 55-280/288.0
DDDNRIVLTpwpqldKCQTTYTNASYIDGYSNR-TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN
.| ||..|       . .  | |||.. . |    .|||.|.|...|| |||......|   |||... .|  | |...|||.   |  .||...||| .
yDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlks

EQVYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA----TWSPSKGPILVHCSAGVGRTGTFIAIDIAL-EQAKREGVVD
..  . .| |.|.... | .   ....  .|||||..|||.    |. . ..| .    .  .|| |..|||||||||||.|  .  |. |  |..|..|
vretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglld

IAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
|  .|.|||.||  |||. .|. |. .||||..
iiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPRD_pd Subfamily PTPRD 6-308 1e-108 359.4 In-house 61-359 (564) alignment 
Range on Protein: 6-308
Range on HMM: 61-359/564.0
DDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAeNYNFGPFTVTLTNEQ
| .|.||.. ..    .. | |||.|||| .| ..||.|||...|. ||||..|...  .|||.|.|.| .| ||..|||..   . ..| .||||..|.
dhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee

VYPDFVIRQLNVkIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNR
 . |..||....     |..|.. .|.| |||||||||..||.|..| ..| |...| .|||.||||||||||||||.||. ||..| |..||| ..|..
eladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvka

LRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCD-SAKAHSDKNRSTSYLPRENFLV
||.||  |||| .||.|.|.|.|| . ||.||. .......||.|.|... |. . |.  |. |.  .... . |     .  ..||| .  |. |.  |
lrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrv

TLKE
.|. 
vlsa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 6-267 1.2e-86 285.7 In-house 59-316 (318) alignment 
Range on Protein: 6-267
Range on HMM: 59-316/318.0
DDNRIVLTPwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfGPFTVTLTNEQ
|. |. |..  . .. .. | ||.||||| .. ..||.|.|. .|. ||||..|. .   |||.|...| .| |...|||.  ...|  |  .|.|..| 
dhtrvkLqm..legeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsy..gklvvelkeev

VYPDFVIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
 . |.|.|...|.  .....| .  ||| |||||.|||. .. |..| .|| ..  ....|||.|||||||||||.|||.|| ||..| |..||. ..|.
elsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvk

RLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
.||.||  |||| |||.|..|..|| ...||||. |..   ...||.| |. .| . .. .|.
qlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6-266 3.5e-86 284.2 In-house 61-318 (319) alignment 
Range on Protein: 6-266
Range on HMM: 61-318/319.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfGPFTVTLTNEQ
|  |.||.. ..  . ...| |||.|||| .|.|||| |.|...|. ||||..|.|.   .||.|.|.|  | |...|||..  |.|  | ..||| .|.
drtrvvlseldg..vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeey..Grlivtleeee

VYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
   |..||.|....  .  .. ...... |.||||.||..|| |. | |..  ...  ..||| ||||||||||||||..|..||. |.|||.|.  .|.
eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvs

RLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQF
||| ||  |||. .|| |...|.|| | .|||||  .. ...|..|.| .. || . |. .|
rlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
0040438 (Phosphotyrosine protein) phosphatases II 6-267 1.3e-84 279.5 In-house 56-312 (317) alignment 
Range on Protein: 6-267
Range on HMM: 56-312/317.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|..|..|.| .      ..| ||||.||.. ..|||| |||...|. ||||..|...  .|||.|.|.|  . ||.||||.   |  ..|.|||||..|.
dhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllsee

VYPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNR
.......|.| |. . |...|.|.|..| |.|||||||.. ..| .. ..| .  ....||.||||||||||||||||....||| ..|| ||.  .|..
elagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavke

LRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
||.||...|||..||.||.||.|| .....| . |.|. .||..|....  .. .  .....
lreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelk
0051299 (Phosphotyrosine protein) phosphatases II 6-231 1.2e-83 276.1 In-house 62-286 (288) alignment 
Range on Protein: 6-231
Range on HMM: 62-286/288.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|..|..|.....     ..| |||||||| .  |||| |||...|. ||||..|...   |||.|.| |  . ||.||||.   . ...|..||||..|.
dhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllsee

VYPDFVIRQLNVKIYD---GSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
|..|...|.| |. .|   |.. |.| |..| |.||||||||....|... ..|.   ....||..|||||||||||||||.|..||| ..||.||. ..
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

VNRLRQQRMKMVQTLDQYVFLHDAVLETV
|.|||.||. ||||..||.|...|.|| .
vkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 6-242 4.1e-83 274.4 In-house 52-288 (297) alignment 
Range on Protein: 6-242
Range on HMM: 52-288/297.0
DDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|..|..|      |.  . | ||||.|||.   |||| |||...|. ||||..|...  .|||.|.| |  . ||.||||... | ...|.|||||....
dhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsve

V--YPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAK---REGVVD
|  ..|...|.| |. . |...|.|.|..| |.|||||||.....|... ..|      .||.||.||||||||||.|||||.|..|.| .   .|| ||
vvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd

IAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANE
|  .|. ||.||. .||||.||.||..|.|| .....| . ...
ileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0050432 (Phosphotyrosine protein) phosphatases II 6-234 1.2e-82 273.0 In-house 81-302 (308) alignment 
Range on Protein: 6-234
Range on HMM: 81-302/308.0
DDNRIVLtpwpqldKCQTTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIA-ENYNFGPFTVTLT
| .|..|       .  ..| ||||.|||   .. |||| |||...|. ||||..|...   |||.|.| |  . ||.||||...  . ...|.|||||.
dhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtll

NEQVYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
.|.|..|...|.| .. .... .|.|.|..| |.|||||||.....|... ..|  .   ..|||.|||||||||||||||.|..||| ..|| ||. ..
seevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfea

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
|..||.||. ||||..||.||..|.|| ... 
vkklReqRpgmvqtpeqylflyralleylklk
0046845 (Phosphotyrosine protein) phosphatases II 6-235 6.7e-82 270.4 In-house 41-278 (284) alignment 
Range on Protein: 6-235
Range on HMM: 41-278/284.0
DDNRIVLTPWPQlDKCQTTYTNASYIDGY-----SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVT
|..|..|..... |   ..| ||||.|||      .. |||| |||...|. ||||..|...   |||.|.| |  . ||.||||..  | ...|.||||
dhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvt

LTNEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG---
|..|.|..|...| | .. .. .. |.|.|..| |||||||||.....|... ..|    .  |..|||.|||||||||||||||.|..||| ..||   
llseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglll

VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
.||. ..|.|||.||. |||||.||.|...|.|| .... 
gvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 6-261 1e-78 259.5 In-house 71-325 (330) alignment 
Range on Protein: 6-261
Range on HMM: 71-325/330.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaENYNFGPFTVTLTNEQ
| .|..|..     . .. | |||.|||| .. ||||.||| ..|. ||||.||. |  .|||.|.|||  ..||.||||.     . .|  .|.. .|.
dfsrvilsvkeG..veesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedet

VYPDFVIRQLNVK-IYDGS--NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
|  |. .|.. |. . |..  ..|  ..|.|.||||| |||  .  ...| |.| ..   | ||| ||||||||||||||..|  ||. | |..||. ..
vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfef

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSA
|.|||.|| .||||. ||.|.. ..||  . ||||. .   | .||.|..  ..|   .
vkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkig
0047943 (Phosphotyrosine protein) phosphatases II 6-230 1e-78 259.9 In-house 51-271 (273) alignment 
Range on Protein: 6-230
Range on HMM: 51-271/273.0
DDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE-NYNFGPFTVTLTNE
|..|..|      .   . | ||||.|||    |||| |||...|. ||||..|...   |||.|.| |  . ||.||||..  |  ...|.|||||..|
dhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllse

QVYPDFVIRQLNVKIYDGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP--SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
....|...|.| .. .. .. |.| |..| |.|||||||.. ..|... ..|. . .   |.||..|||||||||||||||.|..|.| ..|| ||.  .
etkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvlea

VNRLRQQRMKMVQTLDQYVFLHDAVLET
|..||.||. ||||..||.||..|.|| 
vkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 6-232 4.3e-78 258.5 In-house 68-305 (307) alignment 
Range on Protein: 6-232
Range on HMM: 68-305/307.0
DDNRIVLTPWPQLdKCQTTYTNASYI--------DGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPF
|..|..|.. ..     . | ||||.        ||| . .|||| |||...|. ||||..|...   |||.|.|.| .. || ||||..  | ...|.|
dhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnf

TVTLTNEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG
||||..|........|.|.|. .||.. |.|.|..| |.|||||||..  .| .. ..|..   ..|..||.||||||||||||||||....|.| ..||
tvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekeg

V---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
.   ||.  .|..||.||...||...||.||..|.|| ..
tlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6-238 8.1e-78 256.7 In-house 69-297 (298) alignment 
Range on Protein: 6-238
Range on HMM: 69-297/298.0
DDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfGPFTVTLTNEQ
|  |.||.     .. ...| |||....|..|. |||.|.|...|..||||....|.  .|||.|||.|  | |...|||.. .|.|  | .||.| ...
dssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegkety..geitvsllske

VYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWSPSKG--PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.. |...|.|.|. .. . ..... | | |||||.||| .|| .. | ..| | .    |  |..|.|||||||.|||||||  ||..|.| |||.  .|
efadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvv

NRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEI
..||..|...||| .||||...|||| . ....||
kvlRkkrpgavqteeqYvfiyeavlealdsfndei
0039614 (Phosphotyrosine protein) phosphatases II 6-235 1.3e-77 256.5 In-house 69-293 (297) alignment 
Range on Protein: 6-235
Range on HMM: 69-293/297.0
DDNRIVLTPWPQLDKcQTTYTNASYIDGYSN-RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIAenyNFGPFTVTLTNE
|..|..|.| .  |   ..| ||||.|||.    ||||.|||...|. ||||..|...  .|||.|.|.|  . ||.||||..     ..|.|||||...
dhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkv

QVYPDFVIRQLNVKIydgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
........|.|.|.    .. |.|.|... |.|||||||.... |... ..|.   .  |..||.||||||||||||||||....||| ..|| ||.  .
ehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvlea

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
|..||.||...|||..||.||.||.|| .....
vkelreqRpgavqtpsqyrflydallellkrkl
DSPc_SM00195 6-231 3.7e-77 254.6 In-house 39-262 (263) alignment 
Range on Protein: 6-231
Range on HMM: 39-262/263.0
DDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|..|. |.. ..    ...| ||.||.|.... |.|| |||...|. ||||..|.||   |||.|. .|  | ||..|||... .. .|| ..|.|....
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VYP-DFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
 .. ....|.|...  .  ......|||. ..|||||||| ......| ..|  . | |.|||.|||||||||||||..|||.|.. ..|  |||  ||.
kkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

RLRQQRMKMVQTLDQYVFLHDAVLETV
.||.||..|||||.|| |...|.|| .
elRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 6-231 3.7e-77 254.6 In-house 39-262 (263) alignment 
Range on Protein: 6-231
Range on HMM: 39-262/263.0
DDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|..|. |.. ..    ...| ||.||.|.... |.|| |||...|. ||||..|.||   |||.|. .|  | ||..|||... .. .|| ..|.|....
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VYP-DFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
 .. ....|.|...  .  ......|||. ..|||||||| ......| ..|  . | |.|||.|||||||||||||..|||.|.. ..|  |||  ||.
kkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

RLRQQRMKMVQTLDQYVFLHDAVLETV
.||.||..|||||.|| |...|.|| .
elRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 6-229 1.3e-76 252.5 Pfam-A 14-235 (235) alignment 
Range on Protein: 6-229
Range on HMM: 14-235/235.0
DDNRIVLtpwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLT-NE
|..|. |    . .. .. | ||.|..||..  ||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||..  | ...| ..|.|. .|
dktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkeke

Q-VYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.    ....|.|..|  ..........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||...|. ||.  ||
kedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv

NRLRQQRMKMVQTLDQYVFLHDAVLE
..||.||..|||.|.||.||..|.||
kelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 6-229 1.3e-76 252.5 In-house 14-235 (235) alignment 
Range on Protein: 6-229
Range on HMM: 14-235/235.0
DDNRIVLtpwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLT-NE
|..|. |    . .. .. | ||.|..||..  ||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||..  | ...| ..|.|. .|
dktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkeke

Q-VYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.    ....|.|..|  ..........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||...|. ||.  ||
kedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv

NRLRQQRMKMVQTLDQYVFLHDAVLE
..||.||..|||.|.||.||..|.||
kelRkqRpgmvqsleqYiflykaile
0043336 (Phosphotyrosine protein) phosphatases II 6-229 1.6e-76 252.7 In-house 58-275 (278) alignment 
Range on Protein: 6-229
Range on HMM: 58-275/278.0
DDNRIVLTPWPQLDKcqTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPntiAENYNFGPFTVTLTNEQ
| .|..|.. .      ..| ||||.|||.  .||||.|||...|. ||||..|...  .|||.|.|.|  . || ||||    . ...|.|||||..|.
dhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkee

VYPDFVIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNR
...|...|.|.|.   |.. |.| |.|| ..|||||||.  ..|... |.|.   ..|.||.||||||||||||||||....|||...|| ||.  .|..
hlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke

LRQQRMKMVQTLDQYVFLHDAVLE
||.||...|||..||.||..|.||
lreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 6-250 2.2e-74 245.4 In-house 61-305 (307) alignment 
Range on Protein: 6-250
Range on HMM: 61-305/307.0
DDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaENYNFGPFTVTLTNEQ
|..|..|.. .  .  ...| |||.| || .. ||||.|.|.  |. ||||.|.. .   |||..||.| .. ||..|||.   .. ..|   |.| .|.
DktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvsee

VYPDFVIRQLNVKIYD----GSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAG
  .|..||.|.|   .      .||. ..||| |.|.|  ||. |. |. | .||    . ...||.|||||||||.|.|.|.|. |.| | |  |||  
khsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife

IVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQEL
.|  ||.||  .|| |.|||||. |.|.. . |||..  ...| ....|
tvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_PTPRG_pd Subfamily PTPRG 6-244 3.1e-74 245.2 In-house 60-300 (563) alignment 
Range on Protein: 6-244
Range on HMM: 60-300/563.0
DDNRIVLTPWPQLDKCQtTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|  |. |.| |  .|    | ||.|||||    .|||.|||.|.|. ||||.||...   |||.|||.| .. ||..|||.   |  ..| ..|||..|.
drsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieee

VYP-----DFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIA
|        .||..|..|  .  .. .. .||| |.|||||||....| ..  |.  |.     |||.||||||||||||.|..|  |.| ..| .|.. 
vlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvf

GIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYE
|.. ..| ||  .||| .||.|||||.||... ..||.||.. |
gflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 6-233 1.4e-72 238.9 In-house 22-244 (250) alignment 
Range on Protein: 6-233
Range on HMM: 22-244/250.0
DDNRIVLTPWPqLDKcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPNTIAENYnfGPFTVTLTNEQ
|  |.|| .    || .. | |||...||..|  |||.|||...|..||||....||  .|||.|||||  |  ..||||   ||.|  |  ||.| ...
dssrvvLekek.gdk.esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky..Gdvtvsllske

VYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
.. |...|.| .  .  . |. .. |.| ..||| |||..||  . | |.| |.     ..|..|.|||||||.|.|||||  ||..|.| |||.  ...
efadytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvik

RLRQQRMKMVQTLDQYVFLHDAVLETVMC
.||..|...|..|.||||.. ..|. . .
vlrkdrphavesleqyvfvyeiilkalds
0040439 (Phosphotyrosine protein) phosphatases II 6-232 8.5e-72 237.0 In-house 24-247 (249) alignment 
Range on Protein: 6-232
Range on HMM: 24-247/249.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
| .|..|...|      . | ||||||||   ..||| |||...|. ||||..|...  .|||.|.|.|  . ||.||||.   . ...| |||||....
dhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsve

VYPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
|..|...|.| .. . . ..|.| .... |.|||||||..  .|... ..|.   .. |..||.||||||||||||||||....||| ..|. ||.  .|
vkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeav

NRLRQQRMKMVQTLDQYVFLHDAVLETVM
. ||.||...||...||.||..|.|| ..
kllrsqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 6-235 1.4e-70 233.2 In-house 46-276 (278) alignment 
Range on Protein: 6-235
Range on HMM: 46-276/278.0
DDNRIVltpwpqldkcqtTYTNASYIDGYsnRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
| .|..             | ||||||||  ..|||| |||...|. ||||..|...  .|||.|.|.|... ||.||||.   . ...|.|||||..|.
dhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllsee

VYPDFVIRQLNVKIY---DGSNDSHTLTQYHLTSWPDHGVPDYA--TPLMSLHKQVMATWS-------------PSKGPILVHCSAGVGRTGTFIAIDIA
|..|...| |.|      . .. |...|..|...|||||||..   ... .| ... .  .             .|.||.|||||||||||||..|... 
vlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm

LEQAkrEGVVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVLETVMCGD
||.   ||.||.  .|. ||.||.  .||.|.||.||....|| ...|.
lell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0042113 (Phosphotyrosine protein) phosphatases II 6-229 7.5e-70 230.4 In-house 22-241 (245) alignment 
Range on Protein: 6-229
Range on HMM: 22-241/245.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|..|..|.| .      ..| ||||.|||    ||||.|||...|. ||||..|...  .|||.|.. |  . ||.||||.   | ...| |||||..|.
dhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllsee

VYPDFVIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS-PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
...|...|.|.|.  .|.. |.. ..|| ..||||||||.   | .... |    . .|.||.||||||||||||||||....|||...|. |..  .| 
hlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavk

RLRQQRMKMVQTLDQYVFLHDAVLE
.||.||...|||..||.||..|.||
elrsqRpgavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 6-231 5.3e-69 227.3 In-house 53-277 (290) alignment 
Range on Protein: 6-231
Range on HMM: 53-277/290.0
DDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
| .|..|.   . .  .  | ||..| | ......||.|||. ||| ||||.||. .   .||. .. |  | |||.|||..  |. .||.|.|||..|.
dksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

VYP-DFVIRQLNVKIYdgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGV---VDIAG
    ||.||.|.|.     ..|....|.| |.|||||||  |..|..| ..|  . . .. |..|||||||||||| ||||.. |. |.| .   .|.  
avdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfd

IVNRLRQQRMKMVQTLDQYVFLHDAVLETV
.| .||.||  .||| .||.... ||.| |
lvlelrkqraalvqtkeqyelvykavaelv
0037934 (Phosphotyrosine protein) phosphatases II 6-229 2.6e-68 225.5 In-house 23-240 (243) alignment 
Range on Protein: 6-229
Range on HMM: 23-240/243.0
DDNRIVLtpwpqlDKcqTTYTNASYIDGYSnrtKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPntiaENYNFGPFTVTL
|..|..|      .   . | ||..|...    ..||.|||...|. |    |||..|...  .|||.|.|.| .. ||.||||    .....|.|||||
dhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gevtygdftvtl

TNEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--------WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkr
..|....|...| | .. .| .. ... ..|| ..||||||||  ..|......| .           .|.||.|||||||||||||.||... |..   
lseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll..

eGvVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVLE
 | ||.  .|..||.||.  .|||..||.||..|.||
.g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-267 3.6e-67 221.8 In-house 61-324 (325) alignment 
Range on Protein: 6-267
Range on HMM: 61-324/325.0
DDNRIVLTPwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN
| .|.||    . |. .. | ||||.  . ..  |.|.| |. .|. |.|||.  |.    |.|.|.|  .. | .| .|||. ...  .||.. | |  
dksrvvlet..kkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrt

EQVYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------ATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVV
 . . |.| |.|.||  ..  .. .. |..| ||.| ||. . . |.|. . |        . . . .||||||||||||||.||..  ||..   |  |
ieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrv

DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
|| | |..||..| .||.| |||.....|. |..|.|.|..  . .| ||  |.| .  |    .. .|.
difgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 6-241 5.7e-67 220.6 In-house 46-276 (283) alignment 
Range on Protein: 6-241
Range on HMM: 46-276/283.0
DDNRIVLTPWPQldkcqtTYTNASYID---GYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENynFGPFTVTLT
| .|. | . ..      .| ||..|     | .  |.|..|.|...| ||||.....|| ..|||.|.|.|. . || ||||.  .|.  .|.||||| 
dqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed..yGeftvtlr

NEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
.|     |.|..| ..    ....  |. | .  | . |       |. . | .       ||||.||||.|.|||..|||.  ....|. | |||.  .
kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfav

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILAN
|. .|.||| .||||||| ..|..|||  .||||.| | 
vkimreqrmmavqtldqyklvhelvleqalcgdtqiaav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 6-232 2e-66 219.0 In-house 54-277 (281) alignment 
Range on Protein: 6-232
Range on HMM: 54-277/281.0
DDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAeNYNFGPFTVTLTNEQ
|  |...||    .. .| | ||....||.. ...||.|||. ..||.||...|..|   |||||.  |. | || .|||.  . . ..| .||. |.|.
Datrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaee

VYPDFVIRQLNVkiYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS-KGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIV
  . .. |....  .  |... ...| . |.|||||||. .. |.. .|.|. . ... | |...|||||||||||.||.| .......|   .|.  .|
ekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavv

NRLRQQRMKMVQTLDQYVFLHDAVLETVM
. ||..|. ||||. || |.. |||....
aelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 6-230 3.8e-64 211.5 In-house 55-289 (297) alignment 
Range on Protein: 6-230
Range on HMM: 55-289/297.0
DDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|. |.||.  .  .. .. | ||...||| ..  ||| |||.|||  ||||..|... . |||.| . |  . || ||||..  .  .|| ..|.  . .
detrvvlakvd..edeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve

VYPDFVIRQLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM-----------AT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAK
.. |...|.|..|  .  ..| ..| . ..||||.|||. |. |. . ..|            ..    ||. ||.||||||.|||||||..||.|.. .
eeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle

REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
..|.||.   |..||.||  ..|| .||.| . |||| 
evgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN6_pd Subfamily PTPN6 6-228 4.8e-64 211.3 In-house 67-294 (306) alignment 
Range on Protein: 6-228
Range on HMM: 67-294/306.0
DDNRIVLTpwpQLDKCQTTYTNASYIDGYS--NRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnFGPFTVTLTN
|..|..|.   . .  ...| ||.||.. .  .....||.|| ...|. ||||..|||.   |||.|.  | .|.|| .|||.. ...  .|  .|| ..
Dhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvs

EQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK----GPILVHCSAGVGRTGTFIAIDIALEQAKREGV---
|.   |...|.|.|.  . ....... ||| .||||||||     .... ..| .  . ..    |||.||||||.||||||| ||| |.. ...|.   
eksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
.||  .|. .|.||  .||| .|| |.. |. 
idiqklvksvreqrsglvqteqqykfvykaik
subfamily_CG7180_pd Subfamily CG7180 6-235 9.6e-54 177.0 In-house 55-294 (296) alignment 
Range on Protein: 6-235
Range on HMM: 55-294/296.0
DDNRIVLTPWPQLDKcqTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIaeNYNFGPFTVTLTNEQ
| ||.||.     .|  . | ||.|.|..    ..|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .||||.   . ..|.. | ...|.
DynRvvLekldGeek..sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveek

VYPDFVIRQLNVKIY---------DGSNDSHTLTQYHLTSWPD-HGVPDYATPLMSLHKQVMA---TW--SPSKGPILVHCSAGVGRTGTFIAIDIALEQ
 |....||.. ..           . . .  ......|| |.  . ||  .. |. | ..|          | .||..|..| |..|.| ..|||..||.
qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlel

AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
...|. ||. . | .||..| ..|.. ..| .. | .|| |.|. 
vekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRN_pd Subfamily PTPRN 6-231 2.1e-50 166.1 In-house 69-292 (297) alignment 
Range on Protein: 6-231
Range on HMM: 69-292/297.0
DDNRIVLTPwpQLDKCQTTYTNASYIDGYSNR-TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFgpFTVTLTNE
|..|. |.   . .. .. | ||| |     | . .||.|||. .|. |||...|..  | ||..|.|.|   ..|..|||.. .| |..  . | |  |
dhsrvklke..easaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi..yevhlvse

QVYP-DFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGI
 ..  |...| . .|  .  ... |.||.|  |||..|||  | .|. . ..|  ..     ||.||||.|.||||..|.||. |.. ..    .|||  
hiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaat

VNRLRQQRMKMVQTLDQYVFLHDAVLETV
.. ||.|| ..|.| ||. |   || | |
lehlrdqrpglvktkdqfefaltavaeev
subfamily_PTPN14_pd Subfamily PTPN14 6-229 7.4e-49 161.4 In-house 62-294 (300) alignment 
Range on Protein: 6-229
Range on HMM: 62-294/300.0
DDNRIVLTPWPQLdkcQTTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNT--IAENYNFGPFTVTL
.|||. |.|  .    .| | ||| |     ... ..|..|||...|. |||...|...   |||.|. .|. | |. .|.|..   ... .|| | || 
ednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt

TNEQVYPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSL-------HKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAK
   .  . .. ..|..|    |..  |.     | |||||||.  .. .|         ...  . .   || |.||||||||||||  |  |. ..  .
kfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatle

REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 . ..||  ...|||.||| .|||| || |.......
hneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 6-228 2.1e-48 159.6 In-house 51-274 (287) alignment 
Range on Protein: 6-228
Range on HMM: 51-274/287.0
DDNRIVLTPWPQLDkcqTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTL-TNE
||.|..|.  ..|    . | || |. .| .  .|||.|||.  |. ||||......  |....|   | .. || .|||.        | ..|.|   .
ddtrvllsaegelG...sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldyd

QVYPDFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-----MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDI
.  |.. .| | .   .. .... . |..| ||||....  |  |. .  .|     .|  .   ||..||...|.||.|...|. . ... .  | ||.
ikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdv

AGIVNRLRQQRMKMVQTLDQYVFLHDAVL
| .| |||..|  .||.  |. .| .|. 
aavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 6-232 4.7e-40 132.5 In-house 54-278 (307) alignment 
Range on Protein: 6-232
Range on HMM: 54-278/307.0
DDNRIVLTpwpqLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFG--PFTVTLTN
| .|||..    .|   . |  | |.    .  |||..|||...|  .|| .. |||  |..|. .. | .| |||||||    ..  ||  | |....|
dkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan

---EQVYPDF-VIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAIDIALEQA-KREGVVD
   ... ||  .|   ..|. | ...| |....  . |||.|||.     . | . |       . |..|||||||||.|| .|| .  ..  . .   |
lgakklapdedlinvttlkv.dwaqksrtiqhlqwenwpdrgvpqinltainlleav....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd

IAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
.  .|. ||.||   .||  ||..||  .||  .
mkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 6-230 1.5e-37 124.0 In-house 61-286 (305) alignment 
Range on Protein: 6-230
Range on HMM: 61-286/305.0
DDNRIVLT-PWPQldkcqtTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGP--FTVTLT
|.||. |  |||        |  | |.   .|  .|| .| |..||  ||| . .|.|  .| |. ||.|    || .|..    .  .|      ... 
dnnrvklegpwph......eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvk

NEQV-------YPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG
 |           . ....  . |    ....  |.||   ||| |||   . .. | ..      |||||| ||||||.||||. . ..  |.|     
fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagq

VV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
.. |   |....|.|| . .|| .||.|.|. .|. 
iiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 6-70 8e-07 22.9 In-house 50-117 (347) alignment 
Range on Protein: 6-70
Range on HMM: 50-117/347.0
DDNRIVLTPWPQ----LDKcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
|. |.||.|        |.   || |||.|     ....| .| |. .|. |||...   |   .| . 
datrvvlspeksknsradd.vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 7-229 2.6e-64 212.0 In-house 42-266 (274) alignment 
Range on Protein: 7-229
Range on HMM: 42-266/274.0
DNRIVLTPwPQLDKCQTTYTNASYIDGYSNRTK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE--NYNFGPFTVTLTN
  |..|..  . .. ...| || || ||....| ..| |||. .|. ||||.|.||.   |||.|.|||  ..||..|.|...    . ..| . .. ..
nsrvlles.essededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvek

EQVYPDFVIRQLNVKIYDGsndSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS---KGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIA
     |. .|.| .|       ..... |  |.|||| .|| |..|..| ..|  . . .    .|..||||||.|||| ||||.||. | ..|.|||. 
iverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

GIVNRLRQQRMKMVQTLDQYVFLHDAVLE
.||  ||..|  |||| .|| ..| |. .
kivcnlrldrGGmvqtseqyelihralcl
0049772 (Phosphotyrosine protein) phosphatases II 7-229 7e-37 123.2 In-house 59-278 (314) alignment 
Range on Protein: 7-229
Range on HMM: 59-278/314.0
DNRIVLtpwPQLDKCQTTYTNASYIDGYsnrTKFIASQGPMKKTLVDF----------WRLI--WQEKPVSIVM---------------------VTNLK
||| .|   | |.   . | ||||.||.    ||||.|||.. |.|||          ||..  .. ..  |||                      ..| 
dnrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllild

EGTKSKCEQYWPNTIaenynfgpftvtltneqvypdF-------VirqlnvkiydgsndSHTLTQYHLTSWPDHGVPDYATPLMSLhkQVMATWsPSKGP
...   .......                               .              ...  .|. . .||...|. .  .  |  ... .. . .||
gngneptaadlellk.....................eelydpelf..............erlgikylripvpDgsaplledfdefl..efieea.dkggp

ILVHCSAGVGRTGTFIAIDIALEQAkreGVvDIAGIVNRLRQQRM-----KMVQTLDQYVFLHDAVLE
.||||.||.||||||..... . .    || ... .....|..|.      ....|.||.| ..|.||
vlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 8-118 2.2e-14 47.6 In-house 208-312 (440) alignment 
Range on Protein: 8-118
Range on HMM: 208-312/440.0
NRIVLTPWPQLDKCQTTYtnASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNTiAENYNFGPFTVTLTNEQVY
.|.    ||.    ..       ..|||..  |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   .    ||||||     .  
erveqiqwpnphtdkspl..qqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvn.trsvtfgpftvghkgsenm

PDFVIRQLNVK
    .| |..|
nrvkvrtlelk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 8-80 5.9e-08 26.6 In-house 49-118 (332) alignment 
Range on Protein: 8-80
Range on HMM: 49-118/332.0
NRIVLTPwpQldKCQTTYTNASYIDGYSNRTKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
.|. |.|  |    .  . |||..||||... .| .| |.. .|   |||.. . ||  |... .. |  | |.
srvelap..q..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 9-244 2.4e-60 199.3 In-house 64-292 (439) alignment 
Range on Protein: 9-244
Range on HMM: 64-292/439.0
RIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKskceqYWPNTiaENYNFGPFTVTLTNEQVYP
|..|   | .   .. | || ||.|| .   .||.||| |.|  |||||....| | |||.||| |  |     |||    ..  .|  .|    .   |
rvtlqeipgvp..hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielp

DFVIRQLNVK-IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRL
..||| ..|    | ..  .|. |.| ..|||. ||  |. .. . . .  |  .   ||..|||||||||||| ||.|||||| | |  ||| |||. |
nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvl

RQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYE
|.|| .|||.| ||||...|||| .. ||. .. .|..
rkqrkqmvqalcqyvfiynavledivyGdiavtidefk
0044763 (Phosphotyrosine protein) phosphatases II 14-229 1.1e-35 118.2 In-house 9-169 (178) alignment 
Range on Protein: 14-229
Range on HMM: 9-169/178.0
PWPQLDKCQTTYTNASYIDGYsnrtKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAenynfgpftvtltneqvypdfvir
 ..  . . . |.|||.|...     ...|..|     .|...|.....  .||..|. .|. . || .|||                            
lsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag........................

qlnvkiydgsndshtlTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQakreGVvDIAGIVNRLRQQRMkM
                 ||. . .|||||||    .. ... . .  ....||.||||||||||.||..|... ...    |. ..  .....|..|. .
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i

VQTLDQYVFLHDAVLE
|.. .|. .|..  |.
vpnpgqlrqLyefelr
subfamily_PTPN3_pd Subfamily PTPN3 17-231 1e-58 193.5 In-house 59-275 (280) alignment 
Range on Protein: 17-231
Range on HMM: 59-275/280.0
QLDKCQTTYTNASYID----GYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtIAENYNFGPFTVTLTNEQVYPDFVI
.|.. .| | ||.|..    . .  ...||.|||..||  |||...|..|   |||.|.| |  . || ||||.   .. ..| |.|....|.    .|.
klkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvl

RQLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMK
|.| .|  . ........|   ..|||||||| .. .... ..| .. | .. |..||||||.|||| .|....||    ..  | .  || ..|.||. 
relvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqram

MVQTLDQYVFLHDAVLETV
.||| .|| |. .|.|.  
lvqtasqykfvCeailkvy
subfamily_PTPN1_pd Subfamily PTPN1 17-236 1.2e-47 157.0 In-house 50-278 (290) alignment 
Range on Protein: 17-236
Range on HMM: 50-278/290.0
QLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIA-ENYNFG--PFTVTLTNEQVYPDFVIR
.|.. .. | ||| ..    . ..| .|||. .|   ||...|..|  ..||. .. |  . || ||||.    ..  .    ..|.| .|...  ...|
kleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvr

QLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE---GVVDIAGIVNRLRQ
.|...    ..........| |.||| |||.  . ....  .|    . |. .|| ..|||||.||.|||. .|  | . ...     |||   .  ||.
llelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrk

QRMKMVQTLDQYVFLHDAVLETVM--CGDT
.|. ..|| ||  | . |.|| .    ||.
yrlGliqtadqlrfsylaileGakvikgds
subfamily_CG42327_pd Subfamily CG42327 17-159 1.4e-24 81.4 In-house 50-193 (319) alignment 
Range on Protein: 17-159
Range on HMM: 50-193/319.0
QLDKCQTTYTNASYIDGYSN-RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN--TIAENYNFGPFTVTLTNEQVYPDFVIR
. |. .. | .|||. || . .. .||.| .....  ||||..|. .   || .|.| |    .| .|.|   |  ..  .| . ||| . .|   ..| 
igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryais

QLNVKIYDGSnDSHTLTQYHLtSWPDHGVPDYATPLMSLHKQVMAT
 | .|  |..  |  || |    |.. .||   ..|...  .| ..
tlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevrss
subfamily_PTPRB_pd Subfamily PTPRB 18-232 1.1e-79 262.5 In-house 74-286 (293) alignment 
Range on Protein: 18-232
Range on HMM: 74-286/293.0
LDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIaENYNFGPFTVTLTNEQVYPDFVIRQLNV
 |. .. | ||.||.||. . .|||.|||. .|. ||||..|..|   |||.|.| |. | |||.|||..  |. ..|  .|||..|... |.|||.|..
kdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelki

KIydgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW--SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQ
.    ........||| |||||||||. ...|... ..|  .   . ||.||.|||||||||||||||.|  |.. ..| .|||.||| .||..|. .||
ek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvq

TLDQYVFLHDAVLETVM
| .||.|.|..||. ..
tekqYifihqcvldllr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 18-228 1e-31 104.7 In-house 73-287 (310) alignment 
Range on Protein: 18-228
Range on HMM: 73-287/310.0
LDKCQ-TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNT-IAEnyNFGPFTVTLTNEQVyPDFVIRQL
.|| .   |  | |.     |. || ||||...|..||||.|.||.  ||... .  |  . ||  |||   ..|   .|   ||  .|    .| | .|
idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte..tygcirvtnlsess.eefeicnl

NVKIYD-------GSN--DSHTLTQYHLTSWPDHGVPDYATplMSLHKQVMATWspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRL
 | .              .   ..  .   ||| ||||      .. ....|     .|| .||||||..|... .|.........|   ||.  ..  |
avtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktel

RQQRMKMVQTLDQYVFLHDAVL
...|.. .||  ||....   .
lksraiciqtelqyliidrvri
subfamily_PTPRK_pd Subfamily PTPRK 19-266 4.6e-80 263.8 In-house 67-312 (314) alignment 
Range on Protein: 19-266
Range on HMM: 67-312/314.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAEnynFGPFTVTLTNEQVYPDFVIRQLNVK
.  .. | ||..||.| . ..||. |||...|. |||||...|.  ||||.|.|.| .. || .|||.       .|.. |.| . ..  ..|.| ..|.
gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrve

I-YDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
    | .. ... |.. ..||||.|| .|| |..| ..| ..  ...|.|.|||||| ||||||||||| |. ..||||||.  .|  ||.... ||.| 
klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete

DQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQF
.||.|..|..||...||.| | . |..    | ...|. |  | |. .|
eqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 19-302 4.3e-76 251.1 In-house 67-349 (515) alignment 
Range on Protein: 19-302
Range on HMM: 67-349/515.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVk
|. .  | ||||| .. |   .|||||| | .. |||||..||..  |.|||.|||| |.|| .|||.  ..  .|| . | |   .   . ..|.|.| 
dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.

iYDGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
   |.. |.|.||.|.| |||.|||  .. |. | |.| |  .  . |...|||||||||| .|.||  . .||   .||.  .|. .||.|...||| .
.lkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

QYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCDSAKAH--SDKNRSTSYLPRENF
|| |...|||| ..  .| |    .  .||.|.      | | .  .|. |  ..|||    . |....    |||  . || .  
qyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrn
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 19-267 4.4e-72 237.6 In-house 68-313 (315) alignment 
Range on Protein: 19-267
Range on HMM: 68-313/315.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLnvk
|. .  | ||||| .. .   .|||||| | .. ||||...|||. .|||||...|| | || ||||.  |.  .|| . |.| . .   | |.|.|   
dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...

IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
.   |..|.|.||...| |||.||.  .. |. | |.| |   . . ..|||||||||||| .|.||  ..|.||. .||.  .|. ||..|...||| .
vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqtee

QYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
.| |..||||| ..  .| ||   .  .||.|.   . .| | .  .|.
eyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 19-243 3.5e-62 205.2 In-house 75-296 (297) alignment 
Range on Protein: 19-243
Range on HMM: 75-296/297.0
DKCQTTYTNASYIDGysNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIAENynFGPFTVTLTNEQVYPDFVIRQLNVK
|. .  | |||.. |  |. ..|..| ||| |. |||.....|..  |||.....|..| || .||...   .  ||  .|.|.  .    |. |.|.|.
ddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevt

IYDgSNDSHTLTQYHLTSWPDHGVPD--YATPLMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQ
  . .   . . ||. ..|||. |.    |. |. | ..|  ..|  .  |.||||.||||||| ...||  . .||||  ||| |.|..|||.|...||
kgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvq

TLDQYVFLHDAVLETVMCGDTEILANEY
| .|| |.. ||||.... ||.| |. .
tkeqykfvyvavleallsedtriqasyf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 19-229 5.8e-60 197.6 In-house 44-262 (270) alignment 
Range on Protein: 19-229
Range on HMM: 44-262/270.0
DKCQTTYTNASYIDGYSN-RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE--NYNFGPFTVTLTNEQVYPDFVIRQL
.. .|.| || |. |... ..|.||..||.. || .|||.||.||  .|||.|.|.|  ..|||.|||.   |  ....|  .|. ..|.    .....|
edsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrl

NVKiYDGSndSHTLTQYHLTSWPDHGVPDYAT------PLMSLHKQVMATWSP-SK-GPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLR
... ..|.  .. |. .. ..|||||||  .        |... ..| .. .  .| .|.|||||||||||||.||.|||..  .... ||.. |...||
rle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelR

QQRMKMVQTLDQYVFLHDAVLE
..||..||. .|| ||. ||.|
kdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 19-252 1.6e-50 166.6 In-house 69-257 (392) alignment 
Range on Protein: 19-252
Range on HMM: 69-257/392.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskceqywpntiaenynfgpftvtltneqvypdfvirqlnvk
|  .. | |||||... |   .||||||   .| ||||...||.. .|.|||.||||                                           
dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................

iydGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
     .| .| .|.|.| |||..|| ... |. . |.| | .     |...||||||||||  |.||  . .||.  .||.  .|  .|..|  |||| .
...kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtke

QYVFLHDAVLETVMCGDTEILANEYEMKLQELKE
|| |.. |||| ..  .| |    .  .||.|. 
qyafiygavledllwrntlipvvhftdhlqdlst
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 19-229 4.2e-46 151.9 In-house 77-281 (290) alignment 
Range on Protein: 19-229
Range on HMM: 77-281/290.0
DKCQTTYTNASYIDGYsnRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVI-RQLNV
|  .  |  | |..|   .. || .||..|.| .|.||.. |||   |||. .| |  |.|||||.|..  |   || .||. ..|.   . .| . | |
dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsv

KIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
.  | |  .| |  ... ||||. |.  .  |. . . .        ||. ||||||.||||||.||...|.       .|....|  ||. |.. ||  
rdkd.sGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvd

DQYVFLHDAVLE
 ||. | ...|.
iqylalveilld
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 19-229 3.1e-37 122.8 In-house 62-267 (281) alignment 
Range on Protein: 19-229
Range on HMM: 62-267/281.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVK
.|  | |  | ||     .  .| .||| |.|  ||||.||||.  .|||. .. |  . || .|.|       .|  ..|.  .  |   .|  .||. 
nknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls

iYDGsnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPskgpILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQ-QRMKMVQT
 |.|  ... .|..    |||  ||. .  .. . ... |  .|     ..||||||||.||..|..|||.  .    . ||  || .||   |   |||
.yeg..etrlithwlwkewpdwqvpessevmlkilrkirarstp....pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqt

LDQYVFLHDAVLE
|.||...   .|.
lqqymliwkvlld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 19-232 7.7e-37 121.9 In-house 64-272 (288) alignment 
Range on Protein: 19-232
Range on HMM: 64-272/288.0
DKCQtTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVK
| ..  | .|  .    .. ..| .| |.. |.  .|... ..    |||...| |  | | ..|.|  . |.  .| .     ....  | ...   ..
ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllr

IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
|    ...  . . ||  |.|.|||.   . . | . .       . ||.||.|||||||||.| | ||||... .  . |  ....||..|.| .||  
iskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem

QYVFLHDAVLETVM
||...|  ||| ..
qylyvhrcvleell
subfamily_ptpA1_pd Subfamily ptpA1 19-188 1.9e-32 107.5 In-house 71-253 (418) alignment 
Range on Protein: 19-188
Range on HMM: 71-253/418.0
DKCQTTYTNASYIDGYSNrTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE---------NYNFGPFTVTLTNEQVYPD
||  . | || ||||     .||..|||. .|. ||||..|...   |||..   |  . ||..|||. |           |  || ..| | .    |.
dkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe

FVIRQLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------ATWSPSKGPILVHCSAGVGRTGTFIAIDIAL
  |   |...     ... .|||.   |||| .||.. |.  | . .          |  . ||.||||||||||||| .  | .
reiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 19-228 2.3e-23 77.1 In-house 71-282 (302) alignment 
Range on Protein: 19-228
Range on HMM: 71-282/302.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTL---VDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFViRQL
....  | ||| ..  . . . | .| | ...     .|||...||| ||.|..   .| .|   ....|..  .  ..| . |     .   . .  ..
eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.try

NVKIY-DGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMV
 . .  .|  .|   . |.|| |... ||.  . |.   ..| |  .... ....    |.|| |.|..  .|.|. ...  . |. ||. .|.|| ..|
viEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

QTLDQYVFLHDAVL
..|.|||.|. |.|
dslkQyvslyiall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 20-230 3.4e-74 244.5 In-house 72-278 (288) alignment 
Range on Protein: 20-230
Range on HMM: 72-278/288.0
KCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTLTNEQVYPDFVIRQLNVKi
. .. | |||||||. .. |.||.|||. .|. |||.|....|   |||.|.| || |.|||.|||..  .. |.| .||||....   ||| |.| .. 
eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle.

ydGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
   ...  ..|||. ..|||||||. ..||. | .||  . .   |||.|||||||||||||||.| .... ..| ..|.||.|..||.||. .|||| |
..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkq

YVFLHDAVLET
|.|.....|. 
Yefiyevllsl
subfamily_eak_pd Subfamily eak 20-154 1.5e-10 35.0 In-house 75-205 (332) alignment 
Range on Protein: 20-154
Range on HMM: 75-205/332.0
KCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKI
. .  | ||| ..      |.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|.   |...|| . |.  .      .  |.| .. 
lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelsk

ydgSNDSHTLTQYHLTSWPDHGVPDYATpLMSLHK
    |..| .  |..  | .  .| |   ...|.|
...GnethrvlhykvfGwtettlpkyed.flalrk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 21-267 1.2e-78 259.3 In-house 75-315 (315) alignment 
Range on Protein: 21-267
Range on HMM: 75-315/315.0
CQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaeNYNFGPFTVTLTNEQVYPDFVIRQLNVKIY
 .. | ||..||||. . ..||.|||   .. |||||...|.   |||.||| || |.|.|.|||.    .  .|..|||. .|.|. .. .| | |   
phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfg

DgsnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
|   . ... |.|.||||| ||| |..||| |...|.     | |.|.||||||||||||||..|  |.||. | ..|.  .....||.|.||||...||
d...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy

VFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
 |..||.|||..|||| |  . |  . . |      || . || ||.
qfiydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeqfe
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 21-229 1.5e-58 192.8 In-house 27-237 (237) alignment 
Range on Protein: 21-229
Range on HMM: 27-237/237.0
CQTTYTNASYIDGYSNR-TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTLTNEQVYPDFVIRQLNVKI
... | ||.|..|.     |.||.|||.. .  |||...||||   |||.| | || . || .|||.|  .   .| .||.|. .. . |. .| | .  
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkeefsdytvrslllsk

YDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
    ..   . ||..|||||.|||.... |. . |...      .  || ..|||||||||| |. ||  | ||| . ||||   |  . ..|  ..|| 
rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtk

DQYVFLHDAVLE
|||||.|...||
dqyvfihqtile
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-230 6.9e-41 135.0 In-house 55-258 (267) alignment 
Range on Protein: 21-230
Range on HMM: 55-258/267.0
CQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtksKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKIY
 .  | ||||..||  . .||. |.|.|.|  ||. .| ..|   ||..|.  ..   .  ..||  ...  ..  .||  . |.   |. |  |..|. 
keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk

DGSndSHTLTQYHLTSWPD-HGVPDYATPLMSLHKQvmATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
. |  .| .| |.   |        |  ||. .  .          |..|.||.||||.|||. ||  ||.||.|||.||   . ..|.||. .|.|...
nes..ahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtker

YVFLHDAVLET
|...|. . | 
yiyihellaey
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 21-248 3.1e-29 97.0 In-house 44-267 (290) alignment 
Range on Protein: 21-248
Range on HMM: 44-267/290.0
CQTTYTNASYIDgYSNRTKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNTIAENYNFGPFTVTLTNEQVYPD
 .  |  |...  ..|  ..|..| | .|.       . .|| .. |||  ..||. . .| ..      |..| |... |. .|. .||  ..     |
fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

FVIRQLNVKiYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQAK-REGVVDIAGIVNRLRQ
. .|.| || .|. .  .|.| . | .| .  |..    |.|| ..|.|    || |..|||  |. |  .. ||...       .| | .. ... ||.
vetRelvvk.fdd.eeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRMKMVQTLDQYVFLHDAVLetvmcgdteILANEYEMKLQ
|| .....  .. |   ...         .|| |  ..  
qralaitsalelafvdagiv.........llaievldqfa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 21-156 5.7e-25 82.8 In-house 57-193 (297) alignment 
Range on Protein: 21-156
Range on HMM: 57-193/297.0
CQTTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNE---QvYPDFVIRQL
 .. | || |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||..  |. . | . |    .   . .   .. .|
terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltel

NVkIYDgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV
.. ||   ..|  ..     ||||||||     |  .. ||
ql.iyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 21-233 1.6e-12 41.6 In-house 67-281 (303) alignment 
Range on Protein: 21-233
Range on HMM: 67-281/303.0
CQTTYTNASYIDGYSNrTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTLTNEQvyPDFVIRQLNVKIY
....|  |||..  |.  | | .| |. .|  |||..| ..|   ....    |  |   .  .|.   .  .|   .. . . .     .    ..|. 
sdssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkfeersirvgefk..rvelgdgwvlkvl

DGSNDSH--TLTQYHLTSWPDHGVPDYATPLMSL----HKQVMATWSPSKGPILVHCSaGVGRTGTFIAIDIALE-QAKREGVVDIAGIVNRLRQQRMKM
  || ..   |  .|  .||   .|  ..| .       . |.  .|.|. .. .  | |.||.|||  .. |     . .  .|.   .. .|. |.. 
svsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfetahlslhseqasldlvkclenvrngrlha

VQTLDQYVFLHDAVLETVMC
|| | |. ...  . | |. 
vqnlsqfsvvytllaehvld
0041856 (Phosphotyrosine protein) phosphatases II 22-236 2.8e-46 152.8 In-house 18-176 (182) alignment 
Range on Protein: 22-236
Range on HMM: 18-176/182.0
QTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPntiaenynfgpftvtltneqvypdfvirqlnvkiyd
  .| ||....|.   |.||| |||...|. ||.|......  .||..|         .|.|||                                    
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................

gSNDSHTLTQYHLTSWPDHGVPDyATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQakreGvVDIAGIVNRLRQQRMKMVQTLDQYV
 ..  .. .||. ..||||||||    | .. ..| .    ..||.|||||||||||||..|... ...    | |..  .|. .|..|..||.|..||.
.ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyf

FLHDAVLETVMCGDT
||..|.|| .....|
flqlallellllkkt
0046846 (Phosphotyrosine protein) phosphatases II 22-229 7.7e-43 141.6 In-house 11-171 (176) alignment 
Range on Protein: 22-229
Range on HMM: 11-171/176.0
QTTYTNASYIDGYsnrtKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfgpftvtltneqvypdfvirqlnvkiyd
  .| ||..|.|.    ..|| |||. .|| ||........   .|..|...|  . || .|||   ....                             
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

gsndshtltQYHLTSWPDHGVPDYaTPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDialeQAKREGVVDIAGIVNRLRQQRM-KMVQTLDQY
         ||. . ||||||||. . |..| ...   .  ..||.|||||||.|||||..|..      ..|  ...  .. ..|.||. ..||| .||
.........qylhlpwpDhgvpdl.elllellefire.alkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

VFLHDAVLE
 ||....|.
rflyefell
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 22-142 7.5e-13 42.6 In-house 121-235 (244) alignment 
Range on Protein: 22-142
Range on HMM: 121-235/244.0
QTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDfvIRQLNVKIYD
  || |||..      ...| .| |.  | .|||...  |. | ...|     |.  . ..|||..   ..     |||||. . . .  |.  |..|  
gntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpdseplewyeeditvtltdrdefkn..ikasnleies

GSNDSH-TLTQYHLTSWPDHGV
  |.|| .|| . .. ||  | 
dmneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 22-142 3.5e-09 31.1 In-house 12-126 (130) alignment 
Range on Protein: 22-142
Range on HMM: 12-126/130.0
QTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDfvIRQLNVKIYD
. || |||..    . .... .| |. .| .|||...  |. | ...|     |.  . ..|||..   ..     .||||. . .    |.  |..| .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvl....gsveeedeywpdsePlewyeediivtltdrdefkn..ikasnleies

GSNDSH-TLTQYHLTSWPDHGV
  |.|| .|| .... ||  | 
dlneshqaltmfqisnwpsdgt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 23-251 3.4e-68 225.3 In-house 89-311 (319) alignment 
Range on Protein: 23-251
Range on HMM: 89-311/319.0
TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYpdFVIRQLNVKIYDG
. | |||...|| .. |.||.|||.. || ||||.||. .  .||..|      | || ||||. | .... .   |.. .|     .|.|....     
sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgk

SNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
 .|   .||.|.  |||.|||||...|| | |.|         . .|.|||||||||||..|..|. |.. |.|  ||.  .|. ||||| ..|| | ||
ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFLHDAVLETVMCGDTEILANEYEMKLQELK
 |.. |.||  . | ...   ..   |.|| 
kfiysalleehlfghsdvampdfpayleels
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 23-251 2.7e-67 222.3 In-house 53-275 (284) alignment 
Range on Protein: 23-251
Range on HMM: 53-275/284.0
TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYpdFVIRQLNVKIYDG
. | |||.| || .. |.||.|||.. || ||||.||. .  .||..|      | || ||||. | .... .   |.. .|     .|.|....     
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgk

SNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
 .|  ...|.|.  |||.|||||...|| | |.|    .    . .|.|||||||||||..|..|. |.. |.|  ||.  .|. ||||| ..|| | ||
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFLHDAVLETVMCGDTEILANEYEMKLQELK
 |.. |.||  . | ...   ..   |.|| 
kfiysalleehlfghsdvalpdfpayleels
subfamily_PTPN13_pd Subfamily PTPN13 23-230 6.2e-58 191.2 In-house 60-268 (273) alignment 
Range on Protein: 23-230
Range on HMM: 60-268/273.0
TTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGP-FTVTLTNEQVYPDFVIRQLNVKI
..| |||.|      .. ..||.|||. .|  |||...|. |   |.|||. ||. | ||..|||..  ..      ..|.| . | . .||.|.|.|| 
ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd

YDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
 . |..|. ... ....|||||||  |..|. . .. ...   ..|||.||||||.||.||.|.||..|.  .|.  .|.  ||..||.||  .||| ||
se.sgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq

YVFLHDAVLET
|.| . |.|| 
yifvykailev
0043147 (Phosphotyrosine protein) phosphatases II 23-224 2.5e-43 143.1 In-house 5-154 (172) alignment 
Range on Protein: 23-224
Range on HMM: 5-154/172.0
TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegtkskceqywpntiaenynfgpftvtltneqvypdfvirqlnvkIYDG
..| ||||.|.|   ..||| |||.  || ||||......   ||..|.|                                               ||.
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SNDSHTLTQYHLTSWPDHGVPdYATPLMSLHKQVMA-TWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreG-VvDIAGIVNRLRQQRMKMVQTLDQY
.. ...  ||. ..|||||||  .  |... ...       ..||.|||||||||||||..|... |        . ..  .|. .|..|...||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

VFLH
 ||.
rfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 23-232 3.5e-37 122.9 In-house 59-271 (285) alignment 
Range on Protein: 23-232
Range on HMM: 59-271/285.0
TTYTNASYIDGY-SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN--EQVYPDFVIRQLNV-K
  |  ||..     ... .|..|||. .|| |||..|.|||   ..|.  | ||   ||  |.|. . |  .|| . .|||.  |.     ..  | | .
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
  | |..   . . ..  |||.  |. | |.. |.| |     | . || |||||||||| ||. || |  .   .  ...  ||  .|  |.. ||.  
tedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

QYVFLHDAVLETVM
|..||.  ..| ..
qflflyvvlmeyfi
0051082 (Phosphotyrosine protein) phosphatases II 23-228 2.1e-36 120.1 In-house 3-150 (151) alignment 
Range on Protein: 23-228
Range on HMM: 3-150/151.0
TTYTNASYIDGYsnrtkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPNTIaenynfgpftvtltneqvypdfvirqlnvkiydg
..|.|.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|..                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sndsHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwsPSKGPILVHCSAGVGRTGTFIAIDIALEQakregvVDIAGIVNRLRQQRMKMVQTLDQYVF
    ..........|||.|.|..   ..........   ...||.|||||||.|||||..|... |..      |... ... .|..|. .||. .|..|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

LHDAVL
.. |.|
qlfall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 23-230 6.3e-34 112.0 In-house 80-288 (305) alignment 
Range on Protein: 23-230
Range on HMM: 80-288/305.0
TTYTNASYIDGY-SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNE-----QVYPDFVIRQLN
. |  | |.        .||..|||. .|. .|| .. |.|   |||. .  |  | || |||| .  |. ..    |          .  ..  |  ||
sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitlln

VKiYDGSnDSHTLTQYHLTSWPDHGVPDYAtpLMSLhkQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQ-AKREGVVDIAGIVNRLRQQRMKMVQ
.  | |. .. .. . . | ||| |||     | ||  .....   || ||.||||||.||||| .||.  ||. |.   .  .  .|. ||.||   .|
lt.ysgd.qkmsvrhlqwtewpdrgvppck..ltsl..ellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq

TLDQYVFLHDAVLET
.  ||.|.|  .|. 
ndvqylfihrvmlny
0051429 (Phosphotyrosine protein) phosphatases II 24-231 6.5e-56 185.2 In-house 5-225 (272) alignment 
Range on Protein: 24-231
Range on HMM: 5-225/272.0
TYTNASYIDGYSN---RTKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NTIAENYNFGPFTVTLTNEQVYPDF
.| ||....|| .   . ....|.||.. |  ||||| ....  .||..... |  . ||..|||          .. |. ...| ..|||. |....|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYAtpLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVD--------IAGI
..| | .... . .........| |.|||||||. |  | .| ... .     .||.|||||||..||||..|... |..  .| .||        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VNRLRQQRMKMVQTLDQYVFLHDAVLETV
|..||.||...||| .||.||..|.|| .
veelraqrpgavqteeqylflyeallell
0036282 (Phosphotyrosine protein) phosphatases II 24-225 5.6e-47 155.0 In-house 3-164 (174) alignment 
Range on Protein: 24-225
Range on HMM: 3-164/174.0
TYTNASYIDGYSNRTKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiaenynfgpftvtltneqvypdfvirqlnvkiyDGS
.| |||..|..   ...||.|||..     ||.......  ..||....||  . || .|||                                   . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

NDSHTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKrEGVVDIAGIVNRLRQQRMKMVQTLDQYVF
  ...  ||. . |||||||| .. | .. |.|    |  ..||.|||||||||||||..|... | . . |..||.  .| .||.||..|||| .|| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LHD
|..
lyy
subfamily_egg_pd Subfamily egg 24-251 1.2e-29 98.0 In-house 69-292 (307) alignment 
Range on Protein: 24-251
Range on HMM: 69-292/307.0
TYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYWPNTIAENYNFGPFTVTLTNEQVY--PDFVIRQLNVKIyD
 .  | ...|     .|| .| |.| |  ||||...||.   |||.|  ||    .|| |||.. ...  . | .. ..| .|.  .| . |  ..|.  
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.v

GSNDSHTLTQYHLTSWpdHGVPDYATPLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVV--DIAGIVNRLRQQRMKMVQTLDQ
|..|     ..    .  . . |  .||  | |   .       |..|..  || ...|..||.||| .  |  ..   .   |  ||..|   |..  .
Ggddeerflehwqgdv..nnssdvysplrvlrklrnl.....skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvll

YVFLHDAVL--ETVMCGDTEILANEYEMKLQELK
|.|..  ||     . | .. |  .||  |.|  
ylfvyrlvlfffrdvigsakeldvdyerwleers
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 24-235 2.5e-25 83.8 In-house 68-280 (312) alignment 
Range on Protein: 24-235
Range on HMM: 68-280/312.0
TYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIA--ENYNFGPFTVTLTNEQVY----PDFVIRQLNV
 |  | ..   ..  .|...|||...| . ||.|      .||.... . | .  || .|  . ..  .  .   .|   |. ..          | |.|
fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkv

KIYDGSNDShTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
 .    ..|  | .|  .||||||.||     . |    ...    | |.. |||||||||||.. |.  .   .     ..  .   ||..| . |...
vvkatgqes.klnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvf

DQYVFLHDAVLETVMCGD
 |||.   .||| ...  
pqyvyalrcvleflyskg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 24-107 1.1e-09 32.1 In-house 91-171 (349) alignment 
Range on Protein: 24-107
Range on HMM: 91-171/349.0
TYTNASYID--GYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaenyNFGPFTVTLTNEQVY
 | || |.    .|   |.|| | |.  |. ||...|  ..   .. ... || .  ||..|| .      ..  .|| | |   |
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel.....sysnitvklqnssly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 25-125 1.3e-14 48.8 In-house 85-190 (350) alignment 
Range on Protein: 25-125
Range on HMM: 85-190/350.0
YTNASYIDGY----SNRT--KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGpFTVTLTNEQVYPDFVIRQLNVK
| ||.|.       .  .  |.|| |.|...|. ||...| . |   |...|.. |    ||..||..   ....   .. .  |     | ...  .||
YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvk.laskwenimgindsslysadvk

IYDGSND
.    ||
keasdnd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 27-223 1.7e-35 117.2 In-house 79-273 (301) alignment 
Range on Protein: 27-223
Range on HMM: 79-273/301.0
NASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFV--IRQLNVKIYDGSN
 | .|.   .  .|||.|||.|.|  ||| .. | .   |||...  | ...|||.| | .|.|. . | |.....|...  .     |.|.|.   |  
hanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkf

DSHTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFL
...|.| |  ..|.|.|||   . |. |    |     |. ||.||||||.||. .||. ..   . . .  ....  ...||..| . |||  |  ..
atrtvthyqysewtdrgvPkshaelfdl....melvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
0049260 (Phosphotyrosine protein) phosphatases II 30-225 1.4e-42 140.3 In-house 1-144 (152) alignment 
Range on Protein: 30-225
Range on HMM: 1-144/152.0
YIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWpntiaenynfgpftvtltneqvypdfvirqlnvkiydgsndshtl
.|||| . ..||| |||.  || ||||.... .   |||.|.| | .| |||||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 ||. . |||||||| .  |. |.. .   .  ..||.|||||||||||||..|... |        |..  .|...|..|...|.. .|. ||..
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 32-232 3e-26 86.6 In-house 84-289 (302) alignment 
Range on Protein: 32-232
Range on HMM: 84-289/302.0
DGYSNRTKFI-ASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN-EQVYPD------FVIRQLNVKIYDGS
||  .. |       | |.||  .| || | .   .| .....|. . || .|. . . .. .|| .||.  . ..   .      |.. ....| .   
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

-NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVF
 .  .|.   . ..||||| |. | . . . |   . .   |  .|||||||||||||..||   ..  ... | |.. ||  .|| |   ||. .| ..
kkvkktvdilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

LHDAVLETVM
|   |  ..|
lllcvtkglm
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 37-224 3.9e-28 93.0 In-house 4-197 (199) alignment 
Range on Protein: 37-224
Range on HMM: 4-197/199.0
RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKIYDGSND-SHTLTQYHLT
. ..||.| |...|. |||...|.     |||| . .   ..    ||| | .   ..| ..||     . ||..|  | .     .   .  ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 38-224 4.6e-28 92.7 In-house 4-196 (198) alignment 
Range on Protein: 38-224
Range on HMM: 4-196/198.0
TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKIYDGSND-SHTLTQYHLTS
 ..||.| |...|| |||...|.     |||| . .   ..    ||| | .   ..| ..||     . ||..|  | .     .   .  ...| .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 39-261 2.1e-08 27.2 In-house 116-340 (346) alignment 
Range on Protein: 39-261
Range on HMM: 116-340/346.0
KFIASQGPMK---KTLVDFWRLIWQEKpVSIVMVTNLKEGTKSKCEQYWPNTiAENYN-FGPFTVTLTNEQVYPDFVIRQLNVkIYDGSNDSHTLTQYHL
|.| .| |       . ||| .|.||. . .| .    .  |      . .     |.  | . .     .|  |     ..| . .|  ||     .| 
klivaqlpqmenesfvedfwymiyqeq.ihlvylmvpddklkntttslfnde.nggyqytgkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhhh

TSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM--
. |     |  . |.. . .| ..     .  . |    | ||. .||    |..|       .|  |.  ..|||   |... ||  ..  |.. .   
apwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiark

-CGDTEILANEYEMKLQELKEIdsSTGCSA
  |  . .  . .  ..|| ||  |  ||.
rggkkapvnkdinrfidelaei..spacsp
subfamily_hpo-7_pd Subfamily hpo-7 48-251 9.8e-19 62.3 In-house 44-244 (263) alignment 
Range on Protein: 48-251
Range on HMM: 44-244/263.0
KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVypDFVIRQLNVKIYDG-SNDSHTLTQYHLTSWPDHGVPDYA
 .|.  |.. | | |.  .||... .|  . ||..|.|    |   .   .|. |. |   | ... |..  . |     ||...|  . |...  |  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

TPLMSLHKQVmatwSPSKgPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTeilA
   . . | .      || .. ||||.|.||.  |  ....        .    . .|   ... ||..| . ..|  |  |    ||. |.   .    
reilnilkva....rnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa...k

NEYEMKLQELK
.| | | ||..
geleakyqeir
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 50-251 8.8e-23 75.7 In-house 40-235 (255) alignment 
Range on Protein: 50-251
Range on HMM: 40-235/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNeqVYPDFVIRQLNVKIYDG-SNDSHTLTQYHLTSWPDHGVPDYATP
|.  |.. | | |.  .||.....| .. ||..|.|    |   .   .|| |.     | |.| |..  . |     ||.. |. . |...  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LMSLHKQVMAtwspSkGPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVmcgdteILANE
.. . | |      |  ...||||.|.||. .|. ....        .    . .|   ... ||..| . ..|  |  |    ||. |        ..|
ilnilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkge

YEMKLQELK
.| |.||..
leakyqeir
0048076 (Phosphotyrosine protein) phosphatases II 82-228 2.6e-30 100.3 In-house 1-140 (145) alignment 
Range on Protein: 82-228
Range on HMM: 1-140/145.0
QYWPNTIAENYNFGPFTvTLTNEQVYPDFVIRQ-LNVkIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSkGPILVHCSAGVGRTGT
.|||. | ..  .|... |  . . . |. |.  ||.  .. .. ... .||. ..|||||||| .  |... ... .  .   ||.|||||||||||||
pywpseilpglylgslp.taldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

FIAIDIALEqakrEGvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
..|... |.    .| |..  .....|.||...|.. .|. ||....|
lvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 83-225 1.3e-27 91.7 In-house 2-139 (144) alignment 
Range on Protein: 83-225
Range on HMM: 2-139/144.0
YWPNTIAENYNFGPFTVTLTNEQ---------------VYPDFVIRQlnvkiydgsndshtLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSpSKGPI
..|. | ..  .|.. ..|  |.                .|.|..|.               .||. ..||||||||... | .. . . .  . ..||.
snpseilpglylgslptaldlellkklgittvinlteeyepeflere..............giqylhlpwpDhgvpdllellleflefieeale.eggpv

LVHCSAGVGRTGTFIAIDIALeqakREGvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|||||||||||||..|... .    ..| ...  .....|..|. .|.. .|. ||..
lVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 111-184 6.7e-10 34.4 In-house 49-135 (194) alignment 
Range on Protein: 111-184
Range on HMM: 49-135/194.0
VIRQLNVKIYDGSNDSHTLT------------QYHLTSWPDHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAI
....||||..   . ..| .            .|.   .||.| ||.... |  |.     .   ..| ..||| ||.|||||..| 
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_CDC14_pd Subfamily CDC14 112-185 7.4e-08 26.6 In-house 217-284 (328) alignment 
Range on Protein: 112-185
Range on HMM: 217-284/328.0
IRqLNVKIYDGSNDSHTLTQYHltswpDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAID
.| || |.|| ..  ..  ...     |    | .||  .. |. ..    ..| | ||| ||.|||||.||  
vr.LnkklYdakkftdaGfdhk.....DlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacy
PTEN_1 118-183 4.6e-09 31.4 In-house 83-149 (196) alignment 
Range on Protein: 118-183
Range on HMM: 83-149/196.0
KIYDGSNDSHTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIA
. || .   .   .|.  ...|||.|. .  |.   |...  ..  |... .|||| ||.||.|| .|
rsydleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 124-270 1.1e-35 117.8 In-house 86-233 (440) alignment 
Range on Protein: 124-270
Range on HMM: 86-233/440.0
NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVF
 .|.|| |||  .|||.||| .| |.. . ..|  .    ..||.|||||||.||||  ||.|  | .|||   .||  ..| .|..| .|||| .||.|
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

LHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLS
.|.|||| ..|||| || ..   ......  .  |  | || .|.  |
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefegys
PTPc_DSPc_SM00012 129-229 2.2e-36 119.6 In-house 2-105 (105) alignment 
Range on Protein: 129-229
Range on HMM: 2-105/105.0
LTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK--GPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.|||||||........| ..|.   . |.  .|..|||||||||||||.|.||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_PTPDC1_pd Subfamily PTPDC1 131-225 4e-09 31.2 In-house 84-170 (182) alignment 
Range on Protein: 131-225
Range on HMM: 84-170/182.0
QYHLTSWPDHGVPDYATpLMSLHKqVMaTWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkregvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 ..  .|.|.||.   . .. . | |. . . ..| . ||| || ||||  ||  .   .      .. .  .. .|..| | .|| .|  ....
yvynfgwkDygvasler.iLdivk.vv.afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_CDKN3_pd Subfamily CDKN3 133-225 7.4e-06 19.7 In-house 103-190 (202) alignment 
Range on Protein: 133-225
Range on HMM: 103-190/202.0
HLTSWPDHGVPDYATPlMSLHKQVMATWSPSKGpILVHCSAGVGRTGTFIAIDIALEqakrEGVVDIAGIVNRLRQQR-MKMVQTLDQYVFLHD
|    .| .||| |.  . . ...  .    ..  ||||  |.||.   ||  . .     . ...    ...||. .  . .||. || .|..
hhypiadglvpdiasc.lkileelrinlkayrk.tlvhcygglgrsslviaclllyl....ddtiepkdaidklrdlkgsraiqtvkqynylse
DSPc Dual specificity phosphatase, catalytic domain 149-183 6.4e-06 21.1 Pfam-A 58-92 (133) alignment 
Range on Protein: 149-183
Range on HMM: 58-92/133.0
LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
 ..  ......   ... .|||| ||. |..|.|.
eleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 149-183 6.4e-06 21.1 In-house 58-92 (133) alignment 
Range on Protein: 149-183
Range on HMM: 58-92/133.0
LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
 ..  ......   ... .|||| ||. |..|.|.
eleeavefiekaeqkgkkvlVHCqaGisRSatlii
subfamily_eak_pd Subfamily eak 152-233 4.1e-07 23.7 In-house 226-307 (332) alignment 
Range on Protein: 152-233
Range on HMM: 226-307/332.0
LHKQVMATwSPSKGPIlVHCSAGVGRTGTFIAIDIA--LEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMC
. |. . |  ||  || . .. |  |.|.|. ||.   | ..|.. .  .  .. . ...|.. | .  |. |....||. .. 
tlkkyiht.ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
PTPc_motif_SM00404 152-183 2.5e-06 22.4 In-house 68-99 (140) alignment 
Range on Protein: 152-183
Range on HMM: 68-99/140.0
LHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
  .... .   ..| .|||| ||| |..|.|.
kvldfienaekkggkvlVHCqaGvSRSatlii
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 155-231 5.2e-19 63.2 In-house 219-295 (297) alignment 
Range on Protein: 155-231
Range on HMM: 219-295/297.0
QVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
. . .  | . ..||||||||||.|  .  |. |.. ... . |.| |.. ||.|| ..||||.|. .|.||||. .
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 163-226 2.5e-17 57.5 In-house 246-310 (319) alignment 
Range on Protein: 163-226
Range on HMM: 246-310/319.0
SKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|.||. |||| ||||||. || |||... .     |||  .|  .|..| . |.| .|| |..  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 165-228 8.4e-18 59.2 In-house 263-341 (350) alignment 
Range on Protein: 165-228
Range on HMM: 263-341/350.0
GPILVHCSAGVGRTGTFIAIDIALE------Q-AKRE-------GVV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
 |||||||||||||||....|  |.      .  |.         .   |  |||.||.||..|||.|||..|...|.|
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 165-229 3.8e-13 43.5 In-house 266-342 (349) alignment 
Range on Protein: 165-229
Range on HMM: 266-342/349.0
GPILVHCSAGVGRTGTFIAIDIALE---QAKREGV--------V-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 ..||||||| ||||... .|. |.     ..| .           |  ||| ||.||. ||| | |......|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 168-234 4.2e-17 56.3 In-house 2-68 (69) alignment 
Range on Protein: 168-234
Range on HMM: 2-68/69.0
LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
.||||.| ||||||||| . . . | | .|||   |. .|. |  ||    .|.|.|||. |..  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 169-234 6.6e-17 55.6 In-house 2-67 (69) alignment 
Range on Protein: 169-234
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
||||.| ||||||||| . . . | | .|||   |. .|. |  ||   ..|.|.|||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
0050432 (Phosphotyrosine protein) phosphatases II 232-509 2.8e-72 239.0 In-house 13-290 (308) alignment 
Range on Protein: 232-509
Range on HMM: 13-290/308.0
MCGDTEILANEYEMKLQELKE-IDSSTGCSALQSQFDLLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNGYINASYLSGY--REKKAFI
...||.||.. ... ...| . ... .. . |. .|  | .|.| . . .. . ... ||||....|| ..  | |.|...|||||| .||  . ...||
lfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfI

IAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS---ETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSssWDLIQLQVTDWPQ
..|.|..||  |||.|. ...|. ||||. |.|.| | |.||| ..   .....| ..|.| | .....|. |....   .|..|    . ... |.|| 
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges..rtvthfhytnWpd

DGVVREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
.||  .|. .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|. . ..
hgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 234-504 9.4e-67 220.3 In-house 1-276 (298) alignment 
Range on Protein: 234-504
Range on HMM: 1-276/298.0
GDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTP--DPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKA
|.||| |......||.|.... ... . ....|  |..|.   . .     ....  .||| ..... .   | |..     .  |||||.|..|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDnsSSWDLIQLQVTDWPQD
||..| |...|  |||.|........||||  ||| ..  . .|| |......||  |.| |..|   .| ||..... | .  ..  . ||..| ||. 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdk

GVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
|| .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| 
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
subfamily_PTPN6_pd Subfamily PTPN6 236-508 3e-45 149.5 In-house 2-287 (306) alignment 
Range on Protein: 236-508
Range on HMM: 2-287/306.0
TEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCDSAK-AHSDKNRSTSYLPRENFLVTLKEN----NGYINASYLSGY--REKKAFI
|..||.| | . .||.. ..|.. . .. .|. |.|          ..||     |||  . || ..  |.|||.    . ||||.|...    ..|..|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyi

IAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET-TNFGEYFVKLDSSKECNGYIERKFHIHSdKDDNSSSWDLIQLQVTDWPQDG
 .|  ...|  |||.|... .   |||.    | |.| |..|| |.|. ...|.. |.  |.|. . || |.....  |...... ...|.. ..||. |
atqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfksWPdhg

VVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLVYTR
| ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | |    .
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk
0051299 (Phosphotyrosine protein) phosphatases II 245-509 2.2e-69 229.5 In-house 12-277 (288) alignment 
Range on Protein: 245-509
Range on HMM: 12-277/288.0
MKLQELKeidsSTGCSALQSQFDLLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMKNTAR
  ...|.     .| . |. .|. | ...||  .. . . ... .|||....|| ..  | |.     |...||||||..||. |..||..| |..||  
klvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

DFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSD--KDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQ
|||.|. ...|. ||||..|.|.| | |.||| .......|...|.| | .....|. |....      | .. |   .....|.|| .||   |. .|.
dFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

VIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.   |.
flrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 246-504 1.2e-86 285.3 In-house 6-264 (287) alignment 
Range on Protein: 246-504
Range on HMM: 6-264/287.0
KLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKM
|. |. . .  .|    . || .| ||| ..|.|  . |.   ||||.|  |...|. | ||. .. ||||... ||.||||||||.||| ||||.|||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIH
| | .|.|||||| ..|. || |||||...... .||| ..| . .  .||||||.... .. .. .   . | |.|.|.. | | ||.|.| ||.. ..
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkag.dkqqvkqyqitnWdstgkvtepqtillvieemyk

RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | 
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 246-511 1.2e-16 55.0 In-house 13-276 (302) alignment 
Range on Protein: 246-511
Range on HMM: 13-276/302.0
KLQELKEIDSsTGCSALQSQFDLLSQVTPDPDDvfCDSAKAHSDKNRSTSYLPRENFLVTLK-ENNGYINASYLSGYREKKAFIIAQSPMKNTA---RDF
. ...| ..|    . ....|. ....  | .   | . |....||.|. .   .. || |. |.. |.||| ..    ..  |.|| | ....    .|
eeeakklvks.ldtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeF

WKMIVDYKVSAIVMLCGLEEDGEeSCYQYWA-DSET-TNFGEYFVKLDSSKECNGYIeRKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVI
|.|. . |.  .|.| | ||  . .  ...   |.. ...|. ||     .. ..    .. |    .. | |       .| |.|. |  .  .. . .
Wrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaelikta

DDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLvyTRYMS
 .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|  . |.|
akv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl..kQyvs
0045450 (Phosphotyrosine protein) phosphatases II 248-509 9.8e-64 211.3 In-house 15-295 (307) alignment 
Range on Protein: 248-509
Range on HMM: 15-295/307.0
QELKEIDSSTGCSALQSQFDLLSQVTPD-PDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK------ENNGYINASYL--------SGYREKKAFIIAQS
  |. ..  .. . |. .|  | .||.. ...  . . ... ||||....|| ..  | |.      |...||||||         .||. |..||..|.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKECNGYIERKFHIHSDkDDNSSSWDLIQLQVTDWPQDGVVRE
|...|  |||.|. ...|..||||..|.|.| | |.||| |.. . ..|...|.| | ....||. |.....   | .. |  ..... |.|| .||   
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvpps

PRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLVYTRY
. ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||... . |.
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf
0036941 (Phosphotyrosine protein) phosphatases II 250-509 2.4e-66 219.4 In-house 3-268 (297) alignment 
Range on Protein: 250-509
Range on HMM: 3-268/297.0
LKEIDSSTGCSALQSQFDLLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLkENNG--YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVD
|| ...... . |...|. | .. . . .  . . ... .|||....|| ..  | | ...|  ||||||..||. |..||..| |..||  |||.|. .
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

YKVSAIVMLCGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKE--CNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVI
..|. ||||. |.|.| | |.||| .   |. ..|...|.| | ..  ...|. |....     .|. |  . ....|.|| .||   |...|. |. | 
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvr

HRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
...... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.||   |.
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf
0039614 (Phosphotyrosine protein) phosphatases II 250-509 6e-65 215.0 In-house 22-280 (297) alignment 
Range on Protein: 250-509
Range on HMM: 22-280/297.0
LKEIDSSTGCSALQSQFDLLSQVTPDpddVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNG------YINASYLSGYRE-KKAFIIAQSPMKNTARDFW
|. ..  .... |. .|  | ...||     .   ... ||||....|| ..  | || ..|      ||||||..||.  ...||..| |...|  |||
llllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

KMIVDYKVSAIVMLCGLEEDGEeSCYQYWADSETtNFGEYFVKLDSSKECNGYIERKFHIHSdkddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDV
.|. ...|..||||. |.|.|   |.||| .... ..|...|.| . ....||. |....      |. |  . ..|.|.|| .||   ....|.... |
rmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellleflelv

IHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|. . |.
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrf
0047943 (Phosphotyrosine protein) phosphatases II 251-509 1e-66 220.5 In-house 3-263 (273) alignment 
Range on Protein: 251-509
Range on HMM: 3-263/273.0
KEIDSSTGCSALQSQFDLLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPRENFLVTL-KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYK
. .....| . |. .|.|| ...| . .  . . ... ||||....|| ..  | |  ....||||||..||. |..||..| |..||  |||.|. ...
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VSAIVMLCGLEEDGEESCYQYWADSE---TTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
|. ||||. |.|.| | |.||| ...   ....|...|.| | .....|. |.. . . ....  |   .....|.|| .||   .  .|. |..| . .
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrkal

QKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|. . |.
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 254-505 7.6e-82 269.4 In-house 14-270 (290) alignment 
Range on Protein: 254-505
Range on HMM: 14-270/290.0
DSSTGCSALQSQFDLLSQvTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK---E----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIV
. ..| .  ..||  | . .  .  |  . ..  . .||.. ....... .||.   .    .| ||||.|. ||.|||..|..|.|..||..||||.|.
ghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

DYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
. ||..||||.   |.|.. |.|||.||.|...||. .|| . ...|.|||||....... .  ..  ..|.|.| |...| | .| |.|.||  ... |
qekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktq

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLV
 | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .
rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq
0043336 (Phosphotyrosine protein) phosphatases II 254-509 7.2e-64 211.3 In-house 14-268 (278) alignment 
Range on Protein: 254-509
Range on HMM: 14-268/278.0
DSSTGCSALQSQFDLLSQVTPdpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDY
   .....|. .|  | ....  |.  .   ... ||||....|| .. .| |.      ...||||||..||. ...||..| |...|  |||.|. ..
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

KVSAIVMLCGLEEDGEESCYQYWAdSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSssWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQk
.|. ||||..|.|.| . |.|||  ......|...|.| . .....|. |.....  .|..|      ... ..|| .||   . ..|. . .|..... 
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsllldflkavreale.

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
  .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|. . |.
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 256-504 3.3e-59 195.5 In-house 19-269 (319) alignment 
Range on Protein: 256-504
Range on HMM: 19-269/319.0
STGCSALQSQFDLLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKV
|||   |. .| ||.. ..|  ..   | .  ..||| .  |. ..  |.|.|     .  |||||.. ||.|...|| .|.|..||  |||.|. ....
stgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

SAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIhSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG
| .|||..| | ..  . .|| . . ...|.. |.|.. .| ..|| ||...   | ..  . .. . | |.||...| .. ...|... .. . ..|  
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektq

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . 
sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 256-505 2.2e-49 163.1 In-house 17-266 (288) alignment 
Range on Protein: 256-505
Range on HMM: 17-266/288.0
STGCSALQSQFDLLSQVTPDPDDVFCDSAKaHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKV
 .. . ...... |...  . ..     |.   .|||    || .   | ||.     .. ||||||. |...||..| .|.|. .|  |||... ..|.
arnrtgfseeynsLaalektksvtagrlav.nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

SAIVMLCGLEEDGEESCYQYWADSET-TNFGEYFVKLDSSKECNGYIERKFHIHsdkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI
| |||| .| |.|.. | .|| |... .|.|.  |.| .||| . ...||. ..     . .  .. |.| . ||..|| .  . .|.... |   .|. 
stivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

gGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLV
  ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | || 
.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk
subfamily_PTPN23_pd Subfamily PTPN23 256-497 5.1e-46 151.8 In-house 11-259 (288) alignment 
Range on Protein: 256-497
Range on HMM: 11-259/288.0
STGCSALQSQFDLLSQVT-PDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLSGYREK-KAFIIAQSPMKNTARDFWKMIVDYKVSA
  | .||. .| .| |    .  .  .  || .|.||||.  || ..  |.|.. .. |||||.. .       ||..|.|...|. |||.|... |.| 
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCGLEEDGEESCYQYWAD--SETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIH---RQQ
||||   || |.... .||     ||..||.. | | | .| . ..||.....  . |.    ..  ||.| ||. ||   | |.||..| | .    .|
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldada..vksvshlqltsWpelGvPasPetllqfldevesayeavq

KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSK
.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqR
subfamily_PTPN9_pd Subfamily PTPN9 256-496 1.8e-41 137.1 In-house 12-268 (297) alignment 
Range on Protein: 256-496
Range on HMM: 12-268/297.0
STGCSALQSQFDLLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKV
..| . |. ..  . . ..    . .   .| . ||| |  |  ..  |.|.. .      ||||... ||..||||| .| |.|.| .|||.|. . .|
ekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

SAIVMLCGLEEDGEESCYQYWA--DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSssWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-
  |||   ..| |   | |||   . ....||.. |.  . .| . | .|...|.  |...|    ..  |.. ||  || ..  ..|.|.. | ..|  
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees..rkvthfqflsWPdyGvPssaaslldvlekvrekqal

-----------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRS
           .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 257-507 7.2e-113 371.2 In-house 12-283 (301) alignment 
Range on Protein: 257-507
Range on HMM: 12-283/301.0
TGCSALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVS
.    ...|.. |....... .| ....... .......... ...... |.|     . ||||||..||.|||.||.||.|||.| .|||..|...|..
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKEC-------------------NGYIERKFHIHSDKddnsSSWDLIQLQVTDWPQDGVVREP
.|||...|.|. ...|.||| .||...  .....   ..|.                   ||||||||...|||    ||||..||||||||||||||||
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk....sswdvlqlqvtdWpqdGvvrep

RTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL-VYT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  ||
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 257-504 2.6e-92 304.2 In-house 19-269 (305) alignment 
Range on Protein: 257-504
Range on HMM: 19-269/305.0
TGCSALQSQFDLLSQVtPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNG---YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAI
. ...|. |...| .  ... || ...|.......... .|. . . .| ||...   ||||||. ||..||..|.||.|.||| .|||..||..||| |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCGLEEDGEESCYQYWADSETT--NFGEYFVKLDSSKECNGYIERKFHIHSDKDdNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG
|||..| |.|.. |.|||..|.|   .|||. |.| |.|. ..|||||..|  ... .. |  ..|.|.||||..||.... ..|..|..| ..|.|  |
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 257-503 4.2e-26 86.7 In-house 13-262 (307) alignment 
Range on Protein: 257-503
Range on HMM: 13-262/307.0
TGCSALQSQFDLLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE---NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAI
 | .||. .|  |.. ||.   |  .. .| .|||| .    ...  . .|       || | ||    . | || || |..||  .|| |... || ..
kgvqalvdefrvlakktpe..gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLCGLEEDGEESCYQYWADSE--TTNFGEYFVKLDSSKECNGYI---ERKFHIHSDK-DDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ
.||| . | ..  | |||   |  .  |||    .  ..   . .   |    . . | |  . |  . .|| ..||. || .   | . ... |   . 
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn

kigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTT
     |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |
.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 259-402 1.5e-18 61.6 In-house 19-178 (350) alignment 
Range on Protein: 259-402
Range on HMM: 19-178/350.0
CSALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK-------------ENNGYINASYLSGY----REKKAF--IIAQSPMKNTAR
 |  .|.. | |. . . .||   .      ||| .  || |   | ||             . | ||||.||.      . .  |  | .|.|...|  
nstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvd

DFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSettNFGEYFVKLDSSKECNGYIERKFHI
||.|.|.  ||  |..|  . | . | ||.|| .    .. .. ||| | .|  . |.     
dfykvillnkvkvilsltsdvelnlekcyrYWqeg...sydditvklaskwenimgindssly
0040438 (Phosphotyrosine protein) phosphatases II 260-509 2.6e-65 216.1 In-house 18-267 (317) alignment 
Range on Protein: 260-509
Range on HMM: 18-267/317.0
SALQSQFDLLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIV
 ||...|  | ....|  .  . . ... ||||....|| ..  | |.      ...|||||| .|...|..||..|.|..||  |||.|. ...|. ||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGP
||. |||.| | |.||| . ||...|...|.| | .|..|.. |....  .  ..| |  . ... |.|| .||   |...|. .. | . ..  . |||
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
|.||||. |.|.|... . . |||.. || |||... | .|. .||||.|. . |.
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrf
subfamily_PTPRG_pd Subfamily PTPRG 260-503 1.1e-51 170.8 In-house 19-272 (563) alignment 
Range on Protein: 260-503
Range on HMM: 19-272/563.0
SALQSQFD-LLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNG------YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSA
  .. .|. | |.....  |.   ...    ||| .. .. ..  |.|..  |      ||||.|. ||. .||||..| |.|.|. |||.|| . .|. 
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHS----DKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQK
|||.  |.|.| . | .||   |. ..|.  |.| ...    | .|.. |.     .|..  .    .| . |.||. ||   .  ||. .     . .|
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saank

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.|
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
subfamily_PTPRB_pd Subfamily PTPRB 260-503 1e-48 160.9 In-house 25-270 (293) alignment 
Range on Protein: 260-503
Range on HMM: 25-270/293.0
SALQSQFDLLSQVTPDPDdVFCDSAKAHSDKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIV
  .. ... |..|  |   | ...... ..||| |  || ..  | |     .... ||||.|..||. .. || .| |. .|  |||.|. . |.|.||
lrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv

MLCGLEEDGEESCYQYWADS-ETTNFGEYFVKLDSSKECNGYIERKFHIHSdkddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGG
||  | | | . | .|| .  |....|.  |.| ...| . .. |...|.     .... .. |.. | ||. ||  ...|.|. .  | ... ..   .
mltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | |
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt
subfamily_PTPN3_pd Subfamily PTPN3 260-503 2.7e-42 139.6 In-house 15-260 (280) alignment 
Range on Protein: 260-503
Range on HMM: 15-260/280.0
SALQSQFDLLSQVTPDPDDVFCDSAkAHSDKNRSTSYLPRENFLVTLKENN-GYINASYLS----GYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIV
 |.  ||. | .  |. .   .  . .  .|||    || ..  |.|||..  ||||.|..    .    . .|..| |...|| |||.|. . |.| ||
Gavlaqfeqlyrkkpglaisaarkp.enlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLCGLEEDGEESCYQYWADS-ETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDnsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGP
||  | |.|   |.||| .. .....||. ||. ...| . |. |.. ..  . .   .  ..||| ..||. ||  ..  .|.... | .....    |
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk..eerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeeP

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
||||||  . |.||.  . . |    |.  | . .. . .|  .   | |
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 261-504 1.1e-35 118.0 In-house 7-245 (267) alignment 
Range on Protein: 261-504
Range on HMM: 7-245/267.0
ALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGL
 .. .|.|. .....   . .  |.   ..||    || ..  | |.. .. ||||||. ||. |.|||. | |.|||  ||...| |.||. ||.|   
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

eedGEESCYQYWADS--ETTNFGEYFVKLDSSKECNGYIERKFHIhsdKDDNSSSWDLIQLQVTDWPQDGvvrEPRTVLQVIDDV-IHRQQKIGGGPVVV
   ...   ..|     .. .. .  |.    || | |    . .   |  | |. ..       |  .    . .  |. .  .  . | . |. |.||
...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvv

HCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
0046845 (Phosphotyrosine protein) phosphatases II 262-509 2.2e-66 219.5 In-house 2-265 (284) alignment 
Range on Protein: 262-509
Range on HMM: 2-265/284.0
LQSQFDLLSQVTPDPD-DVFCDSAKAHSDKNRSTSYLPRENFLVTLK------ENNGYINASYLSGY-----REKKAFIIAQSPMKNTARDFWKMIVDYK
|. .|  | ..|...  .. .  .... .|||....|| ..  | ||      |...||||||..||     . ||.||..| |..||  |||.|. ...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKECNGYIERKFHIHSDkDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK
|. ||||..|.|.| | |.||| ... . ..|...|.| | .....|. |.. .    . .. |  ......|.|| .||  .|. .|. ...| . ...
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLVYTRY
  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.||   |.
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf
DSPc_SM00195 262-504 4.5e-63 208.4 In-house 2-248 (263) alignment 
Range on Protein: 262-504
Range on HMM: 2-248/263.0
LQSQFDLLSQVTPDPdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVML
|. .|. | . |..  .. .   |. ..|||.. .|| ..  | ||..     . ||||.|..|...||..|..| |...| .|||.|... ||. ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKECN-GYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGP
.  ||.|.| |..|| ..  ....||.. ||| . ....  .| |....  ...  . . .. |.|...||. ||  ... ||...  | ......  ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.||
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 262-504 4.5e-63 208.4 In-house 2-248 (263) alignment 
Range on Protein: 262-504
Range on HMM: 2-248/263.0
LQSQFDLLSQVTPDPdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVML
|. .|. | . |..  .. .   |. ..|||.. .|| ..  | ||..     . ||||.|..|...||..|..| |...| .|||.|... ||. ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKECN-GYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGP
.  ||.|.| |..|| ..  ....||.. ||| . ....  .| |....  ...  . . .. |.|...||. ||  ... ||...  | ......  ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.||
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 262-504 5.9e-56 184.4 In-house 8-252 (283) alignment 
Range on Protein: 262-504
Range on HMM: 8-252/283.0
LQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLS---GYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLC
 . ... | ...  . |. ..||. .  |||    .| ... | ||  .. ||||...     |...| .||||||...| .|||||. | |..||||| 
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

GLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWdLIQLQVTDWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPV
 | || .. | |||    . ..||. | |      | .| ... .. .   .|.   |   || ||    .  .. ...     .. ||  |..   ||.
klqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidW....leygeqaiinslvkfnkvislqteskkgPi

VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 262-504 4.8e-37 122.4 In-house 22-265 (439) alignment 
Range on Protein: 262-504
Range on HMM: 22-265/439.0
LQSQFDLLSQVTPDPDDVFCDSAKAHSD-KNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVM
..  |. .. . ||   . .  |. ... |||  .  . .   |||.|  |     |||| |. || ..| .| .| | |.|. |||..... |.. |||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LCGLEEdgeesCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVV
|. | |      |.||  .. . .|.  |. |   |   |. | |..  ..| .     ..|.. . ||.  |  .   ||. .  .   ..|   ||||
ltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvv

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .|
vhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal
subfamily_PTPRN_pd Subfamily PTPRN 262-503 3e-31 103.2 In-house 31-277 (297) alignment 
Range on Protein: 262-503
Range on HMM: 31-277/297.0
LQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVM
|. ... | .   .|      .|.   .||||.. || ..  |.|||.     . ||||| .      . |.| .|.|. .|  |||.|. .  |  ||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSK-ECNGYIERKFHIHSDKddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIhRQQKIGGGPV
|. |||.| . |..|| |  .  .. | |.| | .  |. |. | |..   .  .| .  . |.    ||. ||  .....|.    |  .  .    |.
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq..tsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpi

VVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTT
|||||| . |.|||. . . |..  |    .|.    . .|  .|| | |
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt
subfamily_CG7180_pd Subfamily CG7180 263-503 6.5e-44 144.7 In-house 16-275 (296) alignment 
Range on Protein: 263-503
Range on HMM: 16-275/296.0
QSQFDLLSQVTPD--PDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVM
. ...|. ..||    .|  ..  |   .|||    .| ... | |..     .. ||||.|  ..  ||..|. . |.|.|  .||... | ..||.|.
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LCGLEEDGEeSCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSD--------KDDNSSSWDLIQLQVTDWPQ-DGVVREPRTVLQVIDDVIHRQ
|.   .  .  . .||     ...|| ||.. ..|.      |.|..           |. .     . ..|.| |.  | |     ......  |   .
Ltktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

QKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | .
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
subfamily_ptpA1_pd Subfamily ptpA1 264-475 4.3e-20 66.8 In-house 25-253 (418) alignment 
Range on Protein: 264-475
Range on HMM: 25-253/418.0
SQFDLLSQVTpDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREkKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCG
 .| || .    | .      |  . ||| |  || .   | ||     | . |||| |. |    | || .| |. ||  |||.|. . ..  ||||  
eefrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsr

LEEDGEESCYQYWADSET-----------TNFGEYFVKLDSSK-EC-NGYIERKFHIHSdkddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHR
  |.    | .|| .                || | |.|     .     | |. ..      .  . |. | |   ||.  .    . . |..  .  |
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf....egetrditqyqyegwpdhnipdhtqpfrqllhsitnr

QQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
|..|        |..||||  | |.| .|.  | .
qnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_PTPN13_pd Subfamily PTPN13 266-503 7.3e-37 122.1 In-house 17-254 (273) alignment 
Range on Protein: 266-503
Range on HMM: 17-254/273.0
FDLLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNGYINASYLSGYR--EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDG
|. | .. |  |..     |.. ||||    || ..  |.|... ||||||..      ..  .|..| |. .|..|||.|. . |.. |.|.    |.|
fkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekg

EESCYQYWADSETTNF---GEYFVKLDSSKECNGYIERKFHIHSDKddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSD
.  | .|| .|.  .    . . |.|   .. .|.  |.....  .   . | .. .|. ..||  || ...  .||..  | . |.    ||.||||| 
kvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsa

TVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
 . |||.. .. . |.  . .  .|| .. . .|. . | | |
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_PTPN1_pd Subfamily PTPN1 270-504 3.7e-31 102.9 In-house 13-257 (290) alignment 
Range on Protein: 270-504
Range on HMM: 13-257/290.0
SQVTPDPDDVFCDSAKAHSDK--NRSTSYLPRENFLVTLK-ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEES
 ... . .|. . .|| ....  ||     | .   ..|. ..| ||||| .   . |. .|..| |. ||.  ||.|. . |  |.|||  . | ..  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CYQYWADSE---TTNFG--EYFVKLDSSKECNGYIERKFHIHSDKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSD
|.|||   |   .  .   .. ||| | .. . |. |.....  | ..  . ....   | ||  || . | . |. . .| .    .   ||.|.||| 
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

TVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTL
 . ||| .| |   | . ....    ||. .|  ..|. . | . | 
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
0045098 (Phosphotyrosine protein) phosphatases II 271-510 1.3e-57 190.6 In-house 17-264 (278) alignment 
Range on Protein: 271-510
Range on HMM: 17-264/278.0
QVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTlkennGYINASYLSGYreKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQY
 ....|.....     . |||| ...|| ..  |      .||||||..||  .|.||..| |...|. |||.|. ......||||..|.|.| | |.||
lllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WADSETTNFGEYFVKLDSSKECNGYIERKFHIHSD--KDDNSSSWDLIQLQVTDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPV
| .... ..|...|.| | .... |. |.....    .. .  |. . .|. . ||  ||  .|  . .|.... . .....             .||||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLVYTRYM
.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..|   |..
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 272-429 1.2e-18 61.7 In-house 81-236 (244) alignment 
Range on Protein: 272-429
Range on HMM: 81-236/244.0
VTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE---NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEescy
. |||  .        | |||  . || .   | | .    | |||||..        .|..| |. .|. |||||... .|  .|.|  .||. |    
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....

qYWADSETTNFGEY--FVKLDSSKECNGYIERKFHIHSDKddNSSSWDLIQLQVTDWPQDGVV
 || |||  .. |    | |    |       .. | ||   | |   |  .|...|| ||  
.ywpdseplewyeeditvtltdrdefknikasnleiesdm..neshqaltmfqisnwpsdgtt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 274-503 9.8e-46 151.0 In-house 29-262 (315) alignment 
Range on Protein: 274-503
Range on HMM: 29-262/315.0
PDPDDVFCDSAKA--HSDKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEES
||||     .|.      |||    || ..  | |     . .. ||||||. .. . ||.| .| | | .  |||.|....||..|||.  ..|.   .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CYQYWAD--SETTNFGEYFVKLDSSKECNGYIERKFhIHSdKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSR
| ||| |  .....||.. |.| | . . . . ||. .   | ..  |  . | | |.||. || ..  ..|..| .|    ..    ...||||  | |
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtr.ksee..srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGr

SGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.|| .|.   ..| | . .||||.. | .|. .|  | |
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 274-503 6e-29 95.6 In-house 30-221 (392) alignment 
Range on Protein: 274-503
Range on HMM: 30-221/392.0
PDPDDVFCDSAK--AHSDKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGees
|.||     .|.      |||    || ..  | |       .. |.||||. ..  .||.| .|.|   .  |||.|. . .|..|.|.  |.|     
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

cyqywadsettnfgeyfvkldsskecngyierkfhihsdKDDNSSSwdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSG
                                       | |.  .    | ..|.||...| .   ..|..| .|     .    |...|||  | |.|
.......................................kgddart..vaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtg

VYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
|  |.   . ..|   .||||..   .|| .|  | |
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 277-502 1.4e-22 74.9 In-house 40-265 (301) alignment 
Range on Protein: 277-502
Range on HMM: 40-265/301.0
DDVFCDSAKAHSDKNRSTSYL--PRENFLVTLKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD-
|..    |  . ||.|  .    |     |  . .   | | ...   . . ||..|.|.|||. ||| |.| |.|  ||||.   |. || | .| .  
dhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

-SETTNFGEYFVKLDSSKEC--NGYIERKFHIHsDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCS
 ||. . | . .|. ...    .  ..|..... |  .. ..  ..  | ..|.. || .    . .... .. . .|    |.|||||. . ||  . .
isekldigrfkikiknkelilnkkiskrtleve.dstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafig

VSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
  .   . .|.  ... .  | .|  .  .| 
teylareveadptieltealkhlrehrwngvq
0040439 (Phosphotyrosine protein) phosphatases II 278-509 4.7e-60 198.6 In-house 2-237 (249) alignment 
Range on Protein: 278-509
Range on HMM: 2-237/249.0
DVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA
.. . . ... ||||....|| ..  | |.       ..||||||..||. |..||..| |...|  |||.|. ......||||. |.| | | |.||| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
.......|...|.| | .....|. |.....     ...|    ..|.|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...  
lggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 . ||| . |. ||.... | .|. .||||... . |.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 279-504 8.6e-19 62.5 In-house 24-281 (297) alignment 
Range on Protein: 279-504
Range on HMM: 24-281/297.0
VFCDSAKAHS-DKNRSTSYLPRENFLVTLKE---NNGYINASYLSGYREKK--AFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA
 |  . .  |  ||| .  |  ..  | |.    .. |||| |.    |..   .|.|| |...|  |||.....  | .|||.. |.||| . |. || 
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DS--ETTNFGEYFVKLDSSKECNgYIERKFhIHSDKDDNSSSWDLIQLQVTDWPQDGVVR----EPR-------------TVLQVID---DVI------H
..  |  . |.. |.  ||   . .   ..         | |  .   |   ||. ||        |              .| ...    ..       
svvqerlkagdvvveflsstsde.fdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
| ..    ...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl
subfamily_PTPN14_pd Subfamily PTPN14 280-506 9.2e-35 115.1 In-house 42-284 (300) alignment 
Range on Protein: 280-506
Range on HMM: 42-284/300.0
FCDSAKAHSDKNRSTSYLPRENFLVTLK----ENNGYINASYLSGY--REKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD
 . . .   .|||    || |.  | |.    ...|||||| ..     ... .|.||.|...| .|||.|. . .|. ||||   |||| | ...|. .
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

S----ETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDT
.    .| .||.. |    |.. . .| ......      .   ... || ||||..|| ..... |. ...|    .  ....       ||.||||. 
leskkktvefgkfkvttkfsedsdsvittglklkhlps..keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

VSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVY
| |.||   . . ..  . . ..|. .| . .|. .   | ||  
vGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaq
0037934 (Phosphotyrosine protein) phosphatases II 282-509 1.1e-50 167.9 In-house 5-233 (243) alignment 
Range on Protein: 282-509
Range on HMM: 5-233/243.0
DSAKAHSDKNRSTSYLPRENFLVTLkENNGYINASYLSGYreKKaFIIAQSPMKNTARD----FWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAdsE-T
 . ... .||| ...|| ..  | | |...||||..  ..  .. .|. | |...|  |    ||.|. ......||||. |.| | | |.|||   . .
allpenlsknrysdilpydhsrvkl.egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev

tNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSsWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYC
 ..|...|.| |......|. |....   . |. . .  |... . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...
.tygdftvtllseehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

SVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLVYTRY
   . |...   | ||.... | .|. .|| ||.|. . |.
aaylmllll...g.vdleeavkllreqRpgkavqtpsqyrf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 282-502 2.4e-19 64.0 In-house 47-274 (310) alignment 
Range on Protein: 282-502
Range on HMM: 47-274/310.0
DSAKAHSDKNRSTSYLPRENFLVTLKE----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT
.. | .  ||| .  . ...  | ||      . || | |.     ...|| .| |.. |  |||.|| . .  .|..||   |.|   |  ||     |
eaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

-NFGEYFVK-L-DSSKE---CNG---YIERKFHIHsDKDDNSSSWDLIQLQVTDWPQDGVVREprtVLQVIDDVIHRQqkIGGGPVVVHCSDTVSRSGVY
  .|   |  | .||.|   ||    ..  .  .  ..  |     .  ..  .||. ||  |     . . . .  |  .  ||.|||||  . | .| 
etygcirvtnlsesseefeicnlavtfvpdnvpvd.eqpanlkelrvslikwpnwpdrgvpde...kchtvpqrllaq..vrhgpcvvhcsagkdrlyvv

CSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
... . ... .    ||. .|   ...|.   . 
valklkidkldrglkvdaeevktellksraiciq
0042113 (Phosphotyrosine protein) phosphatases II 283-509 2.4e-57 189.5 In-house 5-234 (245) alignment 
Range on Protein: 283-509
Range on HMM: 5-234/245.0
SAKAHSDKNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT
. ... ||||....|| .. .| |.. .|     |||||| .||| .. ||..| |...|  |||.|. ......||||. .||.| . |.||| ..|..
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

NFGEYFVKLDSSKECNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
..|...|.| | . ...|. |..... .   .. |   |... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . |||
tygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

CKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 ..|. |..... | .|. .||||.|. . |.
lekelgvsleeavkelrsqRpgavqtpsqyrf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 283-507 4e-46 152.8 In-house 57-280 (319) alignment 
Range on Protein: 283-507
Range on HMM: 57-280/319.0
SAKAHSDKNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCgleedgEESCYQYWADSETT
  .   |||| .  |. ..  | |.  .|     |||||...||. |. .| || |..||  |||.|| .|..|.||.|       .. | |||      
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

NFGEYFVKLDSSKECNGYIERKFHIHSDkDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLE
. ... ||.|| .|.. |. |....  |   .    .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.
keerfkvkvdsveetaeyvvrdielsed.gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

QCKAEGVVDVFQVTKAVRRSKPGAVTTLVYT
. | |  |||... . .|. ..  |  ||  
rmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 283-503 9.8e-44 144.8 In-house 44-273 (325) alignment 
Range on Protein: 283-503
Range on HMM: 44-273/325.0
SAKAHSDKNRSTSYLPREN---FLVTLKEN--NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEdGEESCYQYWADS--E
   .  .|||    .. ..    |.|.|..    |||||||  ...|. |. ||.|. .|  |.|....|.. | .|.|  |.. |...| .|| .   .
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl.gkdrcavywpkemgk

TTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSwdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCS
. .||   ||| . .|   |. |....   |. .. |  . |.|.  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |
sktfGglevklrtieeisdyvhrvldvkqvkkGetrs..vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

VSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.   |..   |  ||.|.. | .|. .|  | |
lysalakvieesrvdifgfvkklrkdrpsmvet
0049772 (Phosphotyrosine protein) phosphatases II 283-504 7.5e-23 77.2 In-house 42-266 (314) alignment 
Range on Protein: 283-504
Range on HMM: 42-266/314.0
SAKAHSDKNRSTSYLPREnFLVTLK----ENNGYINASYLSGYrekKAFIIAQSPMKNTARDF----------WKMIV--DYKVSAIVM-----------
.  .. ||||..  || .  .| |.    .. .||||||..|.   ..||..| |...|  ||          |.|..  |..|  |||           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCGLEEDGeescyQYWADSETTNFGeyfvkldsskecngyierkfHIHSDKDDNssSWDLIQLQVTDWPQdGVVREPRTVLQVIdDVIHR
          |..| . |      ..  ..  ..                      .. |...   .   |..  ...|  | .  .. ..... ..|..
rLdaAlgKtpllildgng.....neptaadlellk....................eelydpelf..erlgikylripvpD.gsaplledfdefl.efiee

QqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTL
     ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|
a..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieql
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 283-480 3.1e-20 67.0 In-house 51-250 (305) alignment 
Range on Protein: 283-480
Range on HMM: 51-250/305.0
SAKAHSDKNRSTSYLPRENFLVTLKE--NNGYINASYLSG-YREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETT
||.    ||| .    ... .| |..     || | |.      .| || || |. .|  .|| |... ||  |||||   | |   | |||     |  
sadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

NF--GEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGL
..  |    ..  ||  .   | .  .       . .  . .|| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   |
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyil

EQCKA
|.   
ekiae
subfamily_PTPN12_pd Subfamily PTPN12 284-503 2.5e-42 139.7 In-house 37-262 (290) alignment 
Range on Protein: 284-503
Range on HMM: 37-262/290.0
AKAHSDKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS--ET
.. .  |||    || ..  |.|.     |...||||... |  .|...| ||.|. .|  |||.|| ...|. .||.| . | |   | .||...  |.
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

TNFGEYFVKLDSSKECN-GYIERKFHIHSDkddnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGL
..|||. |.|.. | .. ... | .... .    . |  . |.. |.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  
lefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

EQCKAEGV---VDVFQVTKAVRRSKPGAVTT
|. ||| .   .|||..   .|. .. .| |
ellkaekipeeldvfdlvlelrkqraalvqt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 284-496 1e-21 72.1 In-house 32-248 (285) alignment 
Range on Protein: 284-496
Range on HMM: 32-248/285.0
AKAHSDKNRSTSYLPRENFLVTLKEN-NGYINASYLS-GYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETTNF
 .|  | || .     |.  | ||.    || ||..    ... ..| .| |. .|  |||.|| . |.. ..||| | | | | |  |. .   |  .|
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GEYFVKLDSSKE--CNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQ
|.| . |   ||    | |   . .   .| .|    . ..||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatir

CKAEGVVDVFQVTKAVRRS
   .  ...... . .|  
imenpniemldivremram
subfamily_PTPRA_pd Subfamily PTPRA 285-505 4.8e-55 181.7 In-house 56-282 (330) alignment 
Range on Protein: 285-505
Range on HMM: 56-282/330.0
KAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNF
.   .|||    || .   | | .        |||||.. ||.||. || || | ..|  |||.|| ..| ..||||  |.|  || |.||| |  .  .
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty

GEYFVKLDSSKECNGYIERKFHIH--SDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQ
|.  |... ..... |  ||| ..  .|. .. .|  . |.  | ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||.
GnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavler

CKAEGVVDVFQVTKAVRRSKPGAVTTLV
 |||..||||.. | .|  .|  | |. 
vkaerkvdvfefvkrlrlqrpqmvqtde
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 286-505 2e-58 192.5 In-house 8-229 (250) alignment 
Range on Protein: 286-505
Range on HMM: 8-229/250.0
AHSDKNRSTSYLPRENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEEsCYQYWADSETTNFG
.  .||| . ... ..  | |....      |||||.| ||.|.||||..|.|...|  |||.|....|...||||  |.| ... . |||   .....|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

EYFVKLDSSKECNGYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  |.| |..|   |. ||. . . |   ...  . ||. . ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | 
dvtvsllskeefadytkrklklskakk..aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVVDVFQVTKAVRRSKPGAVTTLV
| |||||.| |..|. .|.||..| 
ekvvdvfkvikvlrkdrphavesle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 286-503 2.2e-57 189.5 In-house 45-265 (318) alignment 
Range on Protein: 286-503
Range on HMM: 45-265/318.0
AHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFG
.   ||| .  |. ..  | |..        ||||.|. |||.|||.| ||.|. .| .|||.|. . . . ||||  .|| | . . .|| .......|
vnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg

EYFVKLDSSKECNGYIERKFHIHSdkDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  |.|....|.. |. |.|...   .....| .  | ..|.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. ||
klvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerika

EGVVDVFQVTKAVRRSKPGAVTT
|..|||||. | .|. ..  | |
ealvDvfqtvkqlreqrnlmvqt
subfamily_PTPRK_pd Subfamily PTPRK 286-503 2.9e-50 165.9 In-house 42-262 (314) alignment 
Range on Protein: 286-503
Range on HMM: 42-262/314.0
AHSDKNRSTSYLPRENFLVTLK---E--NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTnFG
 . .||||.  |. .. .|.|.   .  .. ||||... .|.  .|||..| |...| .|||... |.. ..||||  | | |   |..|| .  .. .|
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

EYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  |.| ...  . .. | | ..  .   .    . |.| . ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . 
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier

EGVVDVFQVTKAVRRSKPGAVTT
|||||||.. |..| .|.  | |
egvvdvfnavktlrsrkvnmvet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 286-507 9.8e-46 151.5 In-house 24-244 (284) alignment 
Range on Protein: 286-507
Range on HMM: 24-244/284.0
AHSDKNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCgleedgEESCYQYWADSETTNFG
   |||| .  |. ..  | |.   |     |||||...||. |. .| .| |..||  |||.|| .|..|.||.|       .. | |||      . .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

EYFVKLDSSKECNGYIERKFHIhSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCK
.. ||.|| .|.. |. |.... |..  .    .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. |
rfkvkvdsveeseeyvvrdiel.sedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

AEGVVDVFQVTKAVRRSKPGAVTTLVYT
 |  |||... . .|. ..  |  ||  
eekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 286-503 6.8e-45 148.3 In-house 27-253 (274) alignment 
Range on Protein: 286-503
Range on HMM: 27-253/274.0
AHSDKNRSTSYLPRENFLVTLK------ENNGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT-
 .. ||| .. || ||  |.|.      |.  |||| |. ||.| .||.. .| |. ||  |||.||   .|. ||||  |.|  |. | .|. |.| . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---NFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSsswdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVS
   ..|.  .| .. .|.|.|  ||. ... .. .|    ..    ||||   . ....|.|.....| . ...     .|||||||  . | |.. ..|
iserygdveikvekiverndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

IGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
|.. | ..|.||||....  .|  . | | |
iavrqlreeivvdvlkivcnlrldrGGmvqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 286-510 3.5e-34 112.9 In-house 37-269 (287) alignment 
Range on Protein: 286-510
Range on HMM: 37-269/287.0
AHSDKNRSTSYLPRENF--LVTLKENNG--YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET-TNFG
|   ||| .  || ..   |.. . . |  |||| |...|....||| ||.|.  | ||||..... ........    |..   ||.|| . |     |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFV-KLDSSKECNGYIERKFHIHsDKDDNSSsWDLIQLQVTDWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGL
 | |  || ..    |  | . .  | . . .   . ||.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . .
GysvvlldydikePeygvralrli.dletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRYM
.. .  | ||| .|   .|  . . | . |  |..
srledlGrvdvaavvirlreyraalvqavvqlrll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 287-503 5.2e-50 165.2 In-house 51-269 (297) alignment 
Range on Protein: 287-503
Range on HMM: 51-269/297.0
HSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREkkAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEeSCYQYWADSETTNFGE
  .|.| .  || .   |.|.         |.|||.. |...   .|  | |||.|  |||.|..|..||.||||  ..|  . .| .||.|. .|.||.
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGd

YFVKLDSSKECNGYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK
  |.| | .|..|.|.|....  .|    .   . | | ..||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . |
vsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

AEGVVDVFQVTKAVRRSKPGAVTT
 |  ||.|.. | .|...|  | |
rekevdifglvkklrqerpylvqt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 287-439 2.4e-10 34.5 In-house 47-199 (303) alignment 
Range on Protein: 287-439
Range on HMM: 47-199/303.0
HSDKNRSTSYLPRENFLVTLKEnNGYINASYLSGYREKKAfIIAQSPMKNTARDFWKMIVDYKVSAIVMLCG-LEEDGEESCYQYWADSETTNFGEYFVK
  |||| .  .  .   | | .   || ||||    .||| |..| |.  || |||.||.. ||  ...|    | |     . .  . .  .| | ...
nmdknrfvdvicldhskvklsd.ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersir

LDSSKECNGYIERKFHIHSDKDDNSSSWDLIQlQVTDWPQDGVVRE--PRTVLQVI
.   |. .     .... |  . .  |.  .. .  .||.. .  .  |. | |. 
vgefkrvelgdgwvlkvlsvsngdyksflhvh.hykawphnsipsdgspkfvkqiw
Y_phosphatase Protein-tyrosine phosphatase 288-506 1.5e-62 206.5 Pfam-A 2-223 (235) alignment 
Range on Protein: 288-506
Range on HMM: 2-223/235.0
SDKNRSTSYLPRENFLVTL---KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEY
..|||....|| ..  | |   .... ||||.|..||.|||.||..| |.|.|  |||.|....||..||||. ||| |.| | |||   ..|....|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

FVKLD-SSK-ECNGYIERKFHIHSDKDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.|.|  ..| ....|. ||......|...  .  . ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..|
kvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVVDVFQVTKAVRRSKPGAVTTlvY
|. |||.|. | .|...||.|..  .
eeevdvlqivkelRkqRpgmvqs..l
Y_phosphatase Protein-tyrosine phosphatase 288-506 1.5e-62 206.5 In-house 2-223 (235) alignment 
Range on Protein: 288-506
Range on HMM: 2-223/235.0
SDKNRSTSYLPRENFLVTL---KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEY
..|||....|| ..  | |   .... ||||.|..||.|||.||..| |.|.|  |||.|....||..||||. ||| |.| | |||   ..|....|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

FVKLD-SSK-ECNGYIERKFHIHSDKDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.|.|  ..| ....|. ||......|...  .  . ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..|
kvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVVDVFQVTKAVRRSKPGAVTTlvY
|. |||.|. | .|...||.|..  .
eeevdvlqivkelRkqRpgmvqs..l
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 288-510 9.9e-41 134.5 In-house 21-256 (270) alignment 
Range on Protein: 288-510
Range on HMM: 21-256/270.0
SDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT----
.  ||..  ||  .  |.|.|        |||| |. |. . ||..| |..|...| ..||.||.. ||.||||. ||||.| . | .||. .  .    
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

NFGEYFVKLDSSKECNGYIERKFHIHsdkdDNSSSWDLIQLQVTDWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCS
..|.  |   |..  .||| .. ...    .....  |.  . ..||..||.||.        .|... .|  .....  ..|..||||. | |.|.   
edgkikvlalseekeegyiltrlrle....ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

VSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRYM
. |...  . .. ||| .. ...|. ..  | . .  ...
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_Ptp69D_pd Subfamily Ptp69D 289-504 7.1e-54 178.0 In-house 50-272 (307) alignment 
Range on Protein: 289-504
Range on HMM: 50-272/307.0
DKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYF
 |||.    . ..  | ||     |.  |||||.. ||.||| ||.|| |. .|. |||.|| . .|  ||||  |.|  .. | .||.. .....|.  
lknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdil

VKLDSSKECNGYIERKFHIHSDK---DDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
||| |..... ||.|....   |    .   |  ..| . | |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.||
vklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlka

EGVVDVFQVTKAVRRSKPGAVTTL
|  ||.|...| .|. ..  |. |
edkvdifetvkdLrsqRnllvqsl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 289-503 3e-44 146.0 In-house 45-261 (515) alignment 
Range on Protein: 289-503
Range on HMM: 45-261/515.0
DKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETTNFGE
 |||    || ..  | |     . .. |.||||. ..   ||.| .| | | .  |||.......|..|.|.  |.|.    | .|| |  ... .||.
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

YFVKLDSSKECNGYIERKFHIHSDKDdnssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
. |.| | . | | | ||...  ..|    |  . | . |.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |  
ikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt

GVVDVFQVTKAVRRSKPGAVTT
 .||||.. . .|. .|  | |
rmvdvfnfvtnirqkrpylvqt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 289-504 9.5e-43 141.3 In-house 51-265 (315) alignment 
Range on Protein: 289-504
Range on HMM: 51-265/315.0
DKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTnFGEYF
.|||    .. ..  | |     ...  |.||... ||  |. .| ||.|  .. .|||... ..... |||| .| |. .. . .|| | . . .|.. 
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yGkit

VKLDSSKECNGYIERKFHIHSDkdDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV
| . | .  . |  | . . ..  ||    ...||..| ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| .
vtrkseevnteytvrtlsvvfg..dn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaena

VDVFQVTKAVRRSKPGAVTTL
.||... . ||. . ..| ..
idvynfitgvrqnrikmvqva
0041856 (Phosphotyrosine protein) phosphatases II 289-506 5.7e-32 106.2 In-house 3-159 (182) alignment 
Range on Protein: 289-506
Range on HMM: 3-159/182.0
DKNRSTSYLPRENFLvtlkeNNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCgleedgeesCYQYWADSEttnfgeyfvklds
|||| . .|| .. .     .. ||||... |..  . ||..| |...|  ||..|. ......||.|.         ...||.. .             
dknrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.............

skecngyierkfhihsdkddnssSWDLIQLQVTDWPQDGVVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQ
                           ||.. . || .||   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |....
.......................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vslee

VTKAVRRSKPGAVTTLVY
. | ||. .||.|.|. .
avklvrsrRpgmvitpnq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 290-502 9.9e-33 108.0 In-house 59-267 (290) alignment 
Range on Protein: 290-502
Range on HMM: 59-267/290.0
KNRSTSYLPRENFLVTLKE--NNGYINASYLSGYreKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE--TTNFGEYFVK
|||       .   | ||.  .  |. | |. |   |  ||..| ..|.|. |.|.|... ||.|||||| | |||   | ||. . |  .  |||. | 
knrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvl

LDSSKECNGYIERKFHIHSDKDdNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VV
   ... .  | .|     ||| .  .  |  |..  ||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .
cseeddkdaniikktlsvrdkd.sGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkel

DVFQVTKAVRRSKPGAVT
|. .. .|.|.|. ..| 
dlldlvralrnsrlnsvq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 302-490 3.7e-16 53.7 In-house 60-251 (312) alignment 
Range on Protein: 302-490
Range on HMM: 60-251/312.0
FLVTlKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKE------CNG
| ..  ..| || | ..      . |...|.|..||.  ||.. .    ..|..|||. ||| | | .| .|     .. .. |  ..  |       . 
ftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskd

YIERKFHIHSDKDDnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVT
 |  .      |        | . | . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| . 
kithrvlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvll
subfamily_egg_pd Subfamily egg 304-478 1.7e-17 58.1 In-house 68-228 (307) alignment 
Range on Protein: 304-478
Range on HMM: 68-228/307.0
VtlkennGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDgeESCYQYWAD--SETTNF--GEYFVK---LDSSKECNGYI
        .| | ...|      ||.||.|.|||  |||.|.   .|  ||||    |   | |  ||    |..  .  | . ..   .||  .    .
d......dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrv

ERKFHIHSDkddnSSSWdLIQLQVTDWPQDGVVREPRTVLQVIddvihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLEQC
 .   . .|          ..    |. . . |  |  ||. .     |.      ||||.. . ||....  .. | | . 
tklklvGgd....deer.flehwqgdvnnssdvysplrvlrkl.....rnl...skpvvvqdilGvskaatlvaieiallsl
subfamily_eak_pd Subfamily eak 304-401 1.6e-08 28.4 In-house 72-171 (332) alignment 
Range on Protein: 304-401
Range on HMM: 72-171/332.0
VTLKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE--TTNFGEYFVKLDSSKECNGYIERKFH
 . ....|||||| .      . .|..  . ..    ||.|... |  |||.|    | . |   .|. |      .|| . |.  .  . | .  |.. 
ssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrlle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 305-496 6.6e-20 65.9 In-house 61-246 (281) alignment 
Range on Protein: 305-496
Range on HMM: 61-246/281.0
TLKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET--TNFGEYFVKLDSSKECNGYIERKFHI
  |.   || | |.     |. .|..| | |.|  |||.|| . . .|||||| . |   | | .|.        .| .. |. . |   .  .  .. .
pnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl

HSDKDDNssswDLIQLQVTDWPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG-VVDVFQVTKAVRRS
  . .       . .    .||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| .
syegetr....lithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 306-357 7.3e-10 32.9 In-house 66-117 (347) alignment 
Range on Protein: 306-357
Range on HMM: 66-117/347.0
LKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLC
  . ..|||||..     .| .|..| |. .| ||||||.   ||. .| . 
addvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_PTPRD_pd Subfamily PTPRD 307-503 3.9e-62 205.7 In-house 73-266 (564) alignment 
Range on Protein: 307-503
Range on HMM: 73-266/564.0
KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIhSDK
.|.  |||||.. |||..||.| .| |...| .|||.|. ....| ||||  ||| |.. | .|| ...|...||. |.| ...| . |. |.| . ..|
degsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkk

DdNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
. .|.|    | . |.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | |
k.ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 307-509 1.1e-42 141.1 In-house 66-267 (281) alignment 
Range on Protein: 307-509
Range on HMM: 66-267/281.0
KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKECNGYIERKFHIhsd
..|. ||||....||...|..|..|.|. ..  .||.|....|||||||.    | |   |..|| | . ....|.. ||  ...| . ||||||..   
nkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...

KDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTL
. ... . .. ||. | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |.
eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

VYTRY
|  ..
vqyef
subfamily_CG42327_pd Subfamily CG42327 307-439 3.3e-17 57.1 In-house 53-187 (319) alignment 
Range on Protein: 307-439
Range on HMM: 53-187/319.0
KENNGYINASYLSGYREKKA-FIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT----NFGEYFVKLDSSKECNGYIERKFH
.... |..|||. ||.. .. .| || ...... |||... . .   || |. | | | . | .|.  .||      .|.. | |   .  . |.   . 
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

IHsdKDDNSSSWDLIQLQVtDWPQDGVVREPRTVLQVI
..  . |.. | .|      .|.. .|  |..... ..
lk..rvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 307-429 1.7e-16 54.7 In-house 10-127 (130) alignment 
Range on Protein: 307-429
Range on HMM: 10-127/130.0
KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEescyqYWADSETTNFGEYFVKLDSS-KECNGYIERKfHIHSD
 ..| |||||..      . .. .| |. .|. |||||...  |  .|.|  .||. |     || |||  .. |  . . .. ..   .|. . ... .
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikas.nleie

KDDNSSSWDLIQLQVTDWPQDGVV
.| | |   |  .|...|| ||  
sdlneshqaltmfqisnwpsdgtt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 308-503 1.4e-36 121.0 In-house 27-224 (237) alignment 
Range on Protein: 308-503
Range on HMM: 27-224/237.0
ENNGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET-TNFGEYFVKLDSSKECNGYIERKFHIHSD
 .  ||||.|| |.    | .| || |....  |||.|. . | | |||| || |  |. |..|| ...  . .| . | |   .|   |  | . .   
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskr

KDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
   .     . | | | ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . |
ltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt
0043147 (Phosphotyrosine protein) phosphatases II 308-510 1.2e-28 95.3 In-house 3-153 (172) alignment 
Range on Protein: 308-510
Range on HMM: 3-153/172.0
ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLeedgeescyqywadsettnfgeyfvkldsskecngyierkfhihsDKD
|.. |||||||..|.  . ||. | |. ||  |||.|. ......||.|..|                                              .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

DNSSSWDLIQLQVTDWPQDGVVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLVY
    .   ||.. . ||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||..  .
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsq

TRYM
 |. 
yrfl
0046846 (Phosphotyrosine protein) phosphatases II 308-509 9.8e-28 92.5 In-house 10-164 (176) alignment 
Range on Protein: 308-509
Range on HMM: 10-164/176.0
ENNGYINASYLSGYRekkaFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFgeyfvkldsskecngyierkfhihsdkd
..  ||||... |.|    .|. | |. .|  ||..|. .....|.|.|. . | |  .|..|| . |. ..                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

dnssswdliQLQVTDWPQDGVVREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLVY
         | ....||  ||    . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.|  .
.........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

TRY
 |.
yrf
0051429 (Phosphotyrosine protein) phosphatases II 309-505 2.2e-35 118.0 In-house 3-212 (272) alignment 
Range on Protein: 309-505
Range on HMM: 3-212/272.0
NNGYINASYLSGYRE---KKAFIIAQSPMKNTARDFWKMiVDYKVSAIVMLCGLEEDGEESCYQYWA------------DSETTNFGEYFVKLDSSKECN
 .|||||....||     ..... .. |...||.|||..  ......||.|...|| | . |..||.            . .| ..| ..|.| | . ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKFHIHSDKDDNSSsWDLIQLQVTDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------
 || |.. ..   . . .   . .|. |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        
dyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFQVTKAVRRSKPGAVTTLV
.... . .|.  |||| |  
leeaveelraqrpgavqtee
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 309-481 4.4e-21 69.9 In-house 72-249 (305) alignment 
Range on Protein: 309-481
Range on HMM: 72-249/305.0
NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEY----FVKLDSSKECNGYIERKFHI
   || | |.|   . | || .|.|...|  ||| | .. || || ||| | | | . |..|.|  | .. .| |      ||..||.. .   . | ..
pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakv

HSDK----DDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
   .       ...    .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  | 
tetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllag
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 309-503 1.3e-20 68.7 In-house 45-244 (290) alignment 
Range on Protein: 309-503
Range on HMM: 45-244/290.0
NNGYINASYLSgYREKKAFIIAQSPMKNT-------ARDFWKMIVDYKVSAIVMLCGLEEDGEE----SCYQYWADSET--TNFGEYFVKLDSSKECNGY
|..|| |.... . .  ..|. ||| ...         .|| |. . ||  .||||  ||  ..    .| .|  .|.    .|.   ||  |  . .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKFHIHSDKDdnsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVR
..|.  .. |..     . .   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|
etRelvvkfdde...eeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

RSKPGAVTT
. .  |.|.
kqralaits
0044763 (Phosphotyrosine protein) phosphatases II 309-510 4.5e-20 67.5 In-house 17-163 (178) alignment 
Range on Protein: 309-510
Range on HMM: 17-163/178.0
NNGYINASYLSGYrekkaFIIAQSPMkntaRDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETtnfgeyfvkldsskecngyierkfhihsdkdd
   |||||.  ..     ..... |.     |..... ......||.|..  | | ..|..|| ...                                 
rsdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

nssswdlIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLVYTR
       || . . .| .||   .. .|... . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|..  . |
.......iqylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

YM
..
qL
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 309-409 5.7e-13 42.9 In-house 89-192 (349) alignment 
Range on Protein: 309-409
Range on HMM: 89-192/349.0
NNGYINASYLSGY--REKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADsetTNFGEYFVKLDSSKEC----NGYIERKFHI
 . |||| ||.      .| .|  | |.  |  ||.|.|.  .|  .. |   .| . | |..|| .    .. .. |||  | .     .|   | .. 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe...lsysnitvklqnsslyianvqGnslrvstv

HSDKDDN
. ...||
kdtdndn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 309-401 4.1e-08 27.1 In-house 59-154 (332) alignment 
Range on Protein: 309-401
Range on HMM: 59-154/332.0
NNGYINASYLSGYREKKAFIIAQSPMKN-TARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKECNGYIERKFH
.. . |||.. || .| |.|.||.|... |   ||.|. . | | |...  ..|  .  .    .|   | . . |.  |     | .  | ||| 
kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksflhefgaksleecelkakicrkfw
0036282 (Phosphotyrosine protein) phosphatases II 310-510 1.1e-31 105.3 In-house 2-162 (174) alignment 
Range on Protein: 310-510
Range on HMM: 2-162/174.0
NGYINASYLSGYREKKAFIIAQSPMKntardFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADsettnfgeyfvkldsskecngyierkfhihsdkDDN
. |||||.|....  . .|. | |..     ||.|. .......|||. ..|.| . |..|| .                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

SSSWDLIQLQVTDWPQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
. .   ||.. . || .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.|  . |.
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

M
 
l
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 310-503 2.2e-31 103.9 In-house 36-226 (239) alignment 
Range on Protein: 310-503
Range on HMM: 36-226/239.0
NGYINASYLSGYR-EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSeTTNFGEYFVKLDSSKECNGYIERKFHIhSDKDD
. |||||||  |    ||.| .|  .. .. |||.|. . .   |||| || |  .. |.||| || |... .  | |  ..    || | | . |.  .
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtfvm.sqvgq

nSSSWDLIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
 .    . | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | |
.teeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 310-503 2.2e-31 103.9 In-house 35-225 (239) alignment 
Range on Protein: 310-503
Range on HMM: 35-225/239.0
NGYINASYLSGYR-EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSeTTNFGEYFVKLDSSKECNGYIERKFHIhSDKDD
. |||||||  |    ||.| .|  .. .. |||.|. . .   |||| || |  .. |.||| || |... .  | |  ..    || | | . |.  .
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtfvm.sqvgq

nSSSWDLIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
 .    . | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | |
.teeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt
0051082 (Phosphotyrosine protein) phosphatases II 310-505 2.3e-23 77.9 In-house 3-140 (151) alignment 
Range on Protein: 310-505
Range on HMM: 3-140/151.0
NGYINASYLSGYrekkaFIIAQSPMKntarDFWKMIVDYKVSAIVMLCGLEEDGeeSCYQYWADSEttnfgeyfvkldsskecngyierkfhihsdkddn
..|||.||. |.     ... . |.     ||.... ......||.|...|| |   |..|. . .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sssWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLV
    ........|||  |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|..  
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 310-505 2.1e-20 68.0 In-house 67-258 (288) alignment 
Range on Protein: 310-505
Range on HMM: 67-258/288.0
NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETTNFGEYfvkLDSSKECNGYIERKFHIHSDKD
. ||.|  .|  . |. .| ||.|.. |   .|||...  |  ||||| | | | |   .|.     |.. .| .       |. .  |..  ..   . 
dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllri

DNSS---SwDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 .        . .| . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..| 
skegeekv.ivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqte

V
 
m
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 318-505 5.5e-27 89.2 In-house 229-425 (440) alignment 
Range on Protein: 318-505
Range on HMM: 229-425/440.0
LSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEdgeESCYQYWA-DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDdnssSWDLI
. ||  |.||| .| |.  |  |||... ||..|.|.||  |..    .|  ||  .. .  || . |    |.. |    | . ..  ..      .. 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee....vheir

QLQVTDWP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAV
|..|  ||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  |
qfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfv

TTLV
 || 
ptlt
0049260 (Phosphotyrosine protein) phosphatases II 318-510 2.8e-26 87.4 In-house 2-142 (152) alignment 
Range on Protein: 318-510
Range on HMM: 2-142/152.0
LSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWadsettnfgeyfvkldsskecngyierkfhihsdkddnssswdliQ
..||. ...||..| |. ||. |||.|. ......||||. |.|.|.. |.||.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

LQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLVYTRYM
 . . || .||   .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||..  . |. 
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 323-506 5.7e-17 56.5 In-house 3-192 (199) alignment 
Range on Protein: 323-506
Range on HMM: 3-192/199.0
EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQV
 .. .| .| |...|  |||.|. .     |||.   . . |     ||.  .| |...|   |   .      |    . . ..     |. .. . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLVY
| | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...| .
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 324-506 6.6e-17 56.3 In-house 3-191 (198) alignment 
Range on Protein: 324-506
Range on HMM: 3-191/198.0
KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVT
.. .| .| |...|  |||.|. .     |||.   . . |     ||.  .| |...|   |   .      |    . . ..     |. .. . | |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLVY
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...| .
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 329-506 2.3e-21 70.5 In-house 95-276 (302) alignment 
Range on Protein: 329-506
Range on HMM: 95-276/302.0
IAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS--ETTNFGEYFVKLDS-SKECNGYIERK------FHIHSDKDDNSSSWDLIQLQ
    | |.|   .| .| .|.|. .| ||.. ||.|. | .|..|   .. .||.| ||  |  .. . . ..|        |. .|  .     .  |.
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

VTDWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVY
 . ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| .   
fsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 329-492 8.8e-11 36.4 In-house 39-195 (255) alignment 
Range on Protein: 329-492
Range on HMM: 39-195/255.0
IaqspmknTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGV
.       |   |...||  | . .|||| ..|.| | | .|.            |.. ..|  .  . |  .| |   .     ..   . . |..   
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

VREPRTVLQVIDDVihRQQKigggPVVVHCSDTVSRSGVYCsvsigleqckaegV-------------------VDVFQVTKA
 ...| .|...  |  |. |    .||||||  . ||  .              .                   .|  .. . 
Pelareilnilkvv..rdsk....svvvhCstGiGrsaafv.............laelvyqkmirsldttetveldylsllee
subfamily_hpo-7_pd Subfamily hpo-7 334-471 2.3e-09 31.6 In-house 43-174 (263) alignment 
Range on Protein: 334-471
Range on HMM: 43-174/263.0
MKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPR
. .|   |...||  | . .||||  .|.| | | .|.            |.. ..|  .  . .  .. |  ..     .. . . . |..   ....|
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

TVLQVIDdvIHRQQKigggPVVVHCSDTVSRSGVYCSV
 .|....  . |. |    ..|||||  . ||  .  .
eilnilk..varnsk....slvvhcstGiGrsaafsva
0048179 (Phosphotyrosine protein) phosphatases II 403-509 4.1e-11 38.3 In-house 48-136 (144) alignment 
Range on Protein: 403-509
Range on HMM: 48-136/144.0
HsdkddnssswdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVT
.            ||.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...        .| .| ...... . ||.  ||||.
e...........giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavp

TLVYTRY
.  . |.
npgqlrf
0048076 (Phosphotyrosine protein) phosphatases II 409-510 1.9e-11 39.3 In-house 41-135 (145) alignment 
Range on Protein: 409-510
Range on HMM: 41-135/145.0
NSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLVYTR
.  .   ||.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |..... . ||.  ||||..  . |
ellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlr

YM
..
fl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 409-475 3.4e-06 20.6 In-house 214-289 (349) alignment 
Range on Protein: 409-475
Range on HMM: 214-289/349.0
NSSSWDLIQLQVTDWPQDGVVREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIGL
... . |.|||| .|.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 413-473 3.2e-06 21.1 In-house 215-284 (350) alignment 
Range on Protein: 413-473
Range on HMM: 215-284/350.0
WDLIQLQVTDWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSI
. . ||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDs
PTPc_DSPc_SM00012 417-504 1.4e-19 65.6 In-house 4-93 (105) alignment 
Range on Protein: 417-504
Range on HMM: 4-93/105.0
QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTL
....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_CG42327_pd Subfamily CG42327 450-503 6.6e-07 23.3 In-house 246-300 (319) alignment 
Range on Protein: 450-503
Range on HMM: 246-300/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTT
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 455-501 3.3e-06 21.4 In-house 2-48 (69) alignment 
Range on Protein: 455-501
Range on HMM: 2-48/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAV
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv