Gene PTPRD-51 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP108_AA protein Get Run
AqueP108_AA_5-232 phosphatase_domain Get Run
AqueP108_AA_244-510 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-251 4.3e-114 375.8 In-house 57-303 (305) alignment
Range on Protein: 4-251
Range on HMM: 57-303/305.0
TDDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN
..||.|| ||. ..||  .. | ||||.|||... |.|..|||.|.|..||||||..||...|||.|.|.|| |.||.||||....|. .||.|.|.|..
lldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelks

EQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
|. ..|...|.|.. | |....|.|..||.||.|||||||..|| |.|| |.|. ... .|| |.||||||||||||.|||.|||||..|.|.|||....
ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfev

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELK
...||..|||||||||||||||||. | . ||||.|. . ...... ||
lkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-229 3.3e-59 194.9 In-house 18-238 (239) alignment
Range on Protein: 4-229
Range on HMM: 18-238/239.0
TDDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNfgpFTVTLT
| | .|.||      .  .. | ||||.  |    | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.. ..  |   . ||| 
tydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn...lrvtlr

NEQVYPDFVIRQLNVKiYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
. .|. |..|| . .    |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |||..  |||   
ktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

VNRLRQQRMKMVQTLDQYVFLHDAVLE
|. .|..| .|||| .||||.| ||||
vkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4-229 6.2e-59 194.0 In-house 19-239 (239) alignment
Range on Protein: 4-229
Range on HMM: 19-239/239.0
TDDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNfgpFTVTLT
| | .|.||      .  .. | ||||.  |    | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.. ..  |   . ||| 
tydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn...lrvtlr

NEQVYPDFVIRQLNVKiYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
. .|. |..|| . .    |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |||..  |||   
ktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

VNRLRQQRMKMVQTLDQYVFLHDAVLE
|. .|..| .|||| .||||.| ||||
vkairedrphmvqtseqyvfihlavle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 5-237 6e-112 368.2 In-house 52-299 (301) alignment
Range on Protein: 5-237
Range on HMM: 52-299/301.0
DDDNRIVLTPWPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNE
 |||||.|.|.|.||.||..|.|||||||||...||||.|||||||||||||||||||||||||||||||||||||||||||. ||...||||||||.||
yddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvne

QVYPDFVIRQLNVKIYDGSN--------------DSHTLTQYHLTSWPDHGV-PDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALE
|||||||||||||||.||||              .|....|...|.||..|| ....| |...............||..||||..|.|.|......|.||
qvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglE

QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTE
|.|.|||||. ......|......|.||.||....|.. ..... .|.
QckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-233 7.3e-84 276.1 In-house 58-285 (290) alignment
Range on Protein: 5-233
Range on HMM: 58-285/290.0
DDDNRIVLTPWPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENynFGPFTVTLTNE
 |||||.| | ..   |.  | ||.||.||... ..|| |||...||||||.||||||   |||.|| .|  | || ||||.. ...  .|.|...|.||
yddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllne

QVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
... ....|.|.||  . .......|||..|.|...| |....| |.......   . . ...|.||||..|||...|.|........| |||.|.  ..
etlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvl

NRLRQQRMKMVQTLDQYVFLHDAVLETVMC
...|.|....||| .|| .... ||. . .
ksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-237 7.2e-83 272.9 In-house 59-284 (287) alignment
Range on Protein: 5-237
Range on HMM: 59-284/287.0
DDDNRIVLTpwpqldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAenYNFGPFTVTLTNE
 |..|..|       ...  | ||..||||... .||....|| .|...||.||.....  |||....|| ....| ||||.. .    .|.....|.||
pdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellne

QVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.|. ....|.|.||  . ..| ....||..|.|...| |....| |. ..... .   .....|.||||..|||...|.|........|.|||.|.  ..
evnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvl

NRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTE
.. |.|....||| .|| |. |.||| . ...| 
ksqriqkpgsvqtveqykfindivleyldsfety

subfamily_PTPN23_pd Subfamily PTPN23 5-231 3.1e-54 178.7 In-house 55-280 (288) alignment
Range on Protein: 5-231
Range on HMM: 55-280/288.0
DDDNRIVLTpwpqldKCQTTYTNASYIDGYSNR-TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN
.| ||..|       . .  | |||.. . |    .|||.|.|...|| |||......|   |||... .|  | |...|||.   |  .||...||| .
yDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlks

EQVYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA----TWSPSKGPILVHCSAGVGRTGTFIAIDIAL-EQAKREGVVD
..  . .| |.|.... | .   ....  .|||||..|||.    |. . ..| .    .  .|| |..|||||||||||.|  .  |. |  |..|..|
vretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglld

IAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
|  .|.|||.||  |||. .|. |. .||||..
iiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_PTPRD_pd Subfamily PTPRD 6-308 1e-108 359.4 In-house 61-359 (564) alignment
Range on Protein: 6-308
Range on HMM: 61-359/564.0
DDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAeNYNFGPFTVTLTNEQ
| .|.||.. ..    .. | |||.|||| .| ..||.|||...|. ||||..|...  .|||.|.|.| .| ||..|||..   . ..| .||||..|.
dhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee

VYPDFVIRQLNVkIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNR
 . |..||....     |..|.. .|.| |||||||||..||.|..| ..| |...| .|||.||||||||||||||.||. ||..| |..||| ..|..
eladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvka

LRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCD-SAKAHSDKNRSTSYLPRENFLV
||.||  |||| .||.|.|.|.|| . ||.||. .......||.|.|... |. . |.  |. |.  .... . |     .  ..||| .  |. |.  |
lrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrv

TLKE
.|. 
vlsa

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 6-267 1.2e-86 285.7 In-house 59-316 (318) alignment
Range on Protein: 6-267
Range on HMM: 59-316/318.0
DDNRIVLTPwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfGPFTVTLTNEQ
|. |. |..  . .. .. | ||.||||| .. ..||.|.|. .|. ||||..|. .   |||.|...| .| |...|||.  ...|  |  .|.|..| 
dhtrvkLqm..legeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsy..gklvvelkeev

VYPDFVIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
 . |.|.|...|.  .....| .  ||| |||||.|||. .. |..| .|| ..  ....|||.|||||||||||.|||.|| ||..| |..||. ..|.
elsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvk

RLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
.||.||  |||| |||.|..|..|| ...||||. |..   ...||.| |. .| . .. .|.
qlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6-266 3.5e-86 284.2 In-house 61-318 (319) alignment
Range on Protein: 6-266
Range on HMM: 61-318/319.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfGPFTVTLTNEQ
|  |.||.. ..  . ...| |||.|||| .|.|||| |.|...|. ||||..|.|.   .||.|.|.|  | |...|||..  |.|  | ..||| .|.
drtrvvlseldg..vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeey..Grlivtleeee

VYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
   |..||.|....  .  .. ...... |.||||.||..|| |. | |..  ...  ..||| ||||||||||||||..|..||. |.|||.|.  .|.
eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvs

RLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQF
||| ||  |||. .|| |...|.|| | .|||||  .. ...|..|.| .. || . |. .|
rlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref

0040438 (Phosphotyrosine protein) phosphatases II 6-267 1.3e-84 279.5 In-house 56-312 (317) alignment
Range on Protein: 6-267
Range on HMM: 56-312/317.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|..|..|.| .      ..| ||||.||.. ..|||| |||...|. ||||..|...  .|||.|.|.|  . ||.||||.   |  ..|.|||||..|.
dhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllsee

VYPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNR
.......|.| |. . |...|.|.|..| |.|||||||.. ..| .. ..| .  ....||.||||||||||||||||....||| ..|| ||.  .|..
elagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavke

LRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
||.||...|||..||.||.||.|| .....| . |.|. .||..|....  .. .  .....
lreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelk

0051299 (Phosphotyrosine protein) phosphatases II 6-231 1.2e-83 276.1 In-house 62-286 (288) alignment
Range on Protein: 6-231
Range on HMM: 62-286/288.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|..|..|.....     ..| |||||||| .  |||| |||...|. ||||..|...   |||.|.| |  . ||.||||.   . ...|..||||..|.
dhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllsee

VYPDFVIRQLNVKIYD---GSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
|..|...|.| |. .|   |.. |.| |..| |.||||||||....|... ..|.   ....||..|||||||||||||||.|..||| ..||.||. ..
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

VNRLRQQRMKMVQTLDQYVFLHDAVLETV
|.|||.||. ||||..||.|...|.|| .
vkrlreqRpgmvqtpeqyrfvyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 6-242 4.1e-83 274.4 In-house 52-288 (297) alignment
Range on Protein: 6-242
Range on HMM: 52-288/297.0
DDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|..|..|      |.  . | ||||.|||.   |||| |||...|. ||||..|...  .|||.|.| |  . ||.||||... | ...|.|||||....
dhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsve

V--YPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAK---REGVVD
|  ..|...|.| |. . |...|.|.|..| |.|||||||.....|... ..|      .||.||.||||||||||.|||||.|..|.| .   .|| ||
vvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd

IAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANE
|  .|. ||.||. .||||.||.||..|.|| .....| . ...
ileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

0050432 (Phosphotyrosine protein) phosphatases II 6-234 1.2e-82 273.0 In-house 81-302 (308) alignment
Range on Protein: 6-234
Range on HMM: 81-302/308.0
DDNRIVLtpwpqldKCQTTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIA-ENYNFGPFTVTLT
| .|..|       .  ..| ||||.|||   .. |||| |||...|. ||||..|...   |||.|.| |  . ||.||||...  . ...|.|||||.
dhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtll

NEQVYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
.|.|..|...|.| .. .... .|.|.|..| |.|||||||.....|... ..|  .   ..|||.|||||||||||||||.|..||| ..|| ||. ..
seevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfea

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
|..||.||. ||||..||.||..|.|| ... 
vkklReqRpgmvqtpeqylflyralleylklk

0046845 (Phosphotyrosine protein) phosphatases II 6-235 6.7e-82 270.4 In-house 41-278 (284) alignment
Range on Protein: 6-235
Range on HMM: 41-278/284.0
DDNRIVLTPWPQlDKCQTTYTNASYIDGY-----SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVT
|..|..|..... |   ..| ||||.|||      .. |||| |||...|. ||||..|...   |||.|.| |  . ||.||||..  | ...|.||||
dhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvt

LTNEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG---
|..|.|..|...| | .. .. .. |.|.|..| |||||||||.....|... ..|    .  |..|||.|||||||||||||||.|..||| ..||   
llseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglll

VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
.||. ..|.|||.||. |||||.||.|...|.|| .... 
gvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPRA_pd Subfamily PTPRA 6-261 1e-78 259.5 In-house 71-325 (330) alignment
Range on Protein: 6-261
Range on HMM: 71-325/330.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaENYNFGPFTVTLTNEQ
| .|..|..     . .. | |||.|||| .. ||||.||| ..|. ||||.||. |  .|||.|.|||  ..||.||||.     . .|  .|.. .|.
dfsrvilsvkeG..veesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedet

VYPDFVIRQLNVK-IYDGS--NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
|  |. .|.. |. . |..  ..|  ..|.|.||||| |||  .  ...| |.| ..   | ||| ||||||||||||||..|  ||. | |..||. ..
vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfef

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSA
|.|||.|| .||||. ||.|.. ..||  . ||||. .   | .||.|..  ..|   .
vkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkig

0047943 (Phosphotyrosine protein) phosphatases II 6-230 1e-78 259.9 In-house 51-271 (273) alignment
Range on Protein: 6-230
Range on HMM: 51-271/273.0
DDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE-NYNFGPFTVTLTNE
|..|..|      .   . | ||||.|||    |||| |||...|. ||||..|...   |||.|.| |  . ||.||||..  |  ...|.|||||..|
dhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllse

QVYPDFVIRQLNVKIYDGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP--SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
....|...|.| .. .. .. |.| |..| |.|||||||.. ..|... ..|. . .   |.||..|||||||||||||||.|..|.| ..|| ||.  .
etkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvlea

VNRLRQQRMKMVQTLDQYVFLHDAVLET
|..||.||. ||||..||.||..|.|| 
vkllrsqRpgmvqtpeqyrflyealley

0045450 (Phosphotyrosine protein) phosphatases II 6-232 4.3e-78 258.5 In-house 68-305 (307) alignment
Range on Protein: 6-232
Range on HMM: 68-305/307.0
DDNRIVLTPWPQLdKCQTTYTNASYI--------DGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPF
|..|..|.. ..     . | ||||.        ||| . .|||| |||...|. ||||..|...   |||.|.|.| .. || ||||..  | ...|.|
dhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnf

TVTLTNEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG
||||..|........|.|.|. .||.. |.|.|..| |.|||||||..  .| .. ..|..   ..|..||.||||||||||||||||....|.| ..||
tvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekeg

V---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
.   ||.  .|..||.||...||...||.||..|.|| ..
tlldvdlleavkllreqRpgavqnpeqyrflyeallelll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6-238 8.1e-78 256.7 In-house 69-297 (298) alignment
Range on Protein: 6-238
Range on HMM: 69-297/298.0
DDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfGPFTVTLTNEQ
|  |.||.     .. ...| |||....|..|. |||.|.|...|..||||....|.  .|||.|||.|  | |...|||.. .|.|  | .||.| ...
dssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegkety..geitvsllske

VYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWSPSKG--PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.. |...|.|.|. .. . ..... | | |||||.||| .|| .. | ..| | .    |  |..|.|||||||.|||||||  ||..|.| |||.  .|
efadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvv

NRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEI
..||..|...||| .||||...|||| . ....||
kvlRkkrpgavqteeqYvfiyeavlealdsfndei

0039614 (Phosphotyrosine protein) phosphatases II 6-235 1.3e-77 256.5 In-house 69-293 (297) alignment
Range on Protein: 6-235
Range on HMM: 69-293/297.0
DDNRIVLTPWPQLDKcQTTYTNASYIDGYSN-RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIAenyNFGPFTVTLTNE
|..|..|.| .  |   ..| ||||.|||.    ||||.|||...|. ||||..|...  .|||.|.|.|  . ||.||||..     ..|.|||||...
dhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkv

QVYPDFVIRQLNVKIydgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
........|.|.|.    .. |.|.|... |.|||||||.... |... ..|.   .  |..||.||||||||||||||||....||| ..|| ||.  .
ehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvlea

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
|..||.||...|||..||.||.||.|| .....
vkelreqRpgavqtpsqyrflydallellkrkl

DSPc_SM00195 6-231 3.7e-77 254.6 In-house 39-262 (263) alignment
Range on Protein: 6-231
Range on HMM: 39-262/263.0
DDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|..|. |.. ..    ...| ||.||.|.... |.|| |||...|. ||||..|.||   |||.|. .|  | ||..|||... .. .|| ..|.|....
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VYP-DFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
 .. ....|.|...  .  ......|||. ..|||||||| ......| ..|  . | |.|||.|||||||||||||..|||.|.. ..|  |||  ||.
kkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

RLRQQRMKMVQTLDQYVFLHDAVLETV
.||.||..|||||.|| |...|.|| .
elRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 6-231 3.7e-77 254.6 In-house 39-262 (263) alignment
Range on Protein: 6-231
Range on HMM: 39-262/263.0
DDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|..|. |.. ..    ...| ||.||.|.... |.|| |||...|. ||||..|.||   |||.|. .|  | ||..|||... .. .|| ..|.|....
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VYP-DFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
 .. ....|.|...  .  ......|||. ..|||||||| ......| ..|  . | |.|||.|||||||||||||..|||.|.. ..|  |||  ||.
kkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

RLRQQRMKMVQTLDQYVFLHDAVLETV
.||.||..|||||.|| |...|.|| .
elRkqRpgmvqtleqYlfiyeaileyi

Y_phosphatase Protein-tyrosine phosphatase 6-229 1.3e-76 252.5 Pfam-A 14-235 (235) alignment
Range on Protein: 6-229
Range on HMM: 14-235/235.0
DDNRIVLtpwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLT-NE
|..|. |    . .. .. | ||.|..||..  ||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||..  | ...| ..|.|. .|
dktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkeke

Q-VYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.    ....|.|..|  ..........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||...|. ||.  ||
kedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv

NRLRQQRMKMVQTLDQYVFLHDAVLE
..||.||..|||.|.||.||..|.||
kelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 6-229 1.3e-76 252.5 In-house 14-235 (235) alignment
Range on Protein: 6-229
Range on HMM: 14-235/235.0
DDNRIVLtpwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLT-NE
|..|. |    . .. .. | ||.|..||..  ||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||..  | ...| ..|.|. .|
dktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkeke

Q-VYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
.    ....|.|..|  ..........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||...|. ||.  ||
kedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv

NRLRQQRMKMVQTLDQYVFLHDAVLE
..||.||..|||.|.||.||..|.||
kelRkqRpgmvqsleqYiflykaile

0043336 (Phosphotyrosine protein) phosphatases II 6-229 1.6e-76 252.7 In-house 58-275 (278) alignment
Range on Protein: 6-229
Range on HMM: 58-275/278.0
DDNRIVLTPWPQLDKcqTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPntiAENYNFGPFTVTLTNEQ
| .|..|.. .      ..| ||||.|||.  .||||.|||...|. ||||..|...  .|||.|.|.|  . || ||||    . ...|.|||||..|.
dhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkee

VYPDFVIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNR
...|...|.|.|.   |.. |.| |.|| ..|||||||.  ..|... |.|.   ..|.||.||||||||||||||||....|||...|| ||.  .|..
hlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke

LRQQRMKMVQTLDQYVFLHDAVLE
||.||...|||..||.||..|.||
lreqRpgavqtpsqyrflyealle

subfamily_Ptp69D_pd Subfamily Ptp69D 6-250 2.2e-74 245.4 In-house 61-305 (307) alignment
Range on Protein: 6-250
Range on HMM: 61-305/307.0
DDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaENYNFGPFTVTLTNEQ
|..|..|.. .  .  ...| |||.| || .. ||||.|.|.  |. ||||.|.. .   |||..||.| .. ||..|||.   .. ..|   |.| .|.
DktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvsee

VYPDFVIRQLNVKIYD----GSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAG
  .|..||.|.|   .      .||. ..||| |.|.|  ||. |. |. | .||    . ...||.|||||||||.|.|.|.|. |.| | |  |||  
khsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife

IVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQEL
.|  ||.||  .|| |.|||||. |.|.. . |||..  ...| ....|
tvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

subfamily_PTPRG_pd Subfamily PTPRG 6-244 3.1e-74 245.2 In-house 60-300 (563) alignment
Range on Protein: 6-244
Range on HMM: 60-300/563.0
DDNRIVLTPWPQLDKCQtTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|  |. |.| |  .|    | ||.|||||    .|||.|||.|.|. ||||.||...   |||.|||.| .. ||..|||.   |  ..| ..|||..|.
drsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieee

VYP-----DFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIA
|        .||..|..|  .  .. .. .||| |.|||||||....| ..  |.  |.     |||.||||||||||||.|..|  |.| ..| .|.. 
vlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvf

GIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYE
|.. ..| ||  .||| .||.|||||.||... ..||.||.. |
gflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 6-233 1.4e-72 238.9 In-house 22-244 (250) alignment
Range on Protein: 6-233
Range on HMM: 22-244/250.0
DDNRIVLTPWPqLDKcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPNTIAENYnfGPFTVTLTNEQ
|  |.|| .    || .. | |||...||..|  |||.|||...|..||||....||  .|||.|||||  |  ..||||   ||.|  |  ||.| ...
dssrvvLekek.gdk.esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky..Gdvtvsllske

VYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
.. |...|.| .  .  . |. .. |.| ..||| |||..||  . | |.| |.     ..|..|.|||||||.|.|||||  ||..|.| |||.  ...
efadytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvik

RLRQQRMKMVQTLDQYVFLHDAVLETVMC
.||..|...|..|.||||.. ..|. . .
vlrkdrphavesleqyvfvyeiilkalds

0040439 (Phosphotyrosine protein) phosphatases II 6-232 8.5e-72 237.0 In-house 24-247 (249) alignment
Range on Protein: 6-232
Range on HMM: 24-247/249.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
| .|..|...|      . | ||||||||   ..||| |||...|. ||||..|...  .|||.|.|.|  . ||.||||.   . ...| |||||....
dhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsve

VYPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIV
|..|...|.| .. . . ..|.| .... |.|||||||..  .|... ..|.   .. |..||.||||||||||||||||....||| ..|. ||.  .|
vkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeav

NRLRQQRMKMVQTLDQYVFLHDAVLETVM
. ||.||...||...||.||..|.|| ..
kllrsqRpgavqnpeqyrflyeallelll

0045098 (Phosphotyrosine protein) phosphatases II 6-235 1.4e-70 233.2 In-house 46-276 (278) alignment
Range on Protein: 6-235
Range on HMM: 46-276/278.0
DDNRIVltpwpqldkcqtTYTNASYIDGYsnRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
| .|..             | ||||||||  ..|||| |||...|. ||||..|...  .|||.|.|.|... ||.||||.   . ...|.|||||..|.
dhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllsee

VYPDFVIRQLNVKIY---DGSNDSHTLTQYHLTSWPDHGVPDYA--TPLMSLHKQVMATWS-------------PSKGPILVHCSAGVGRTGTFIAIDIA
|..|...| |.|      . .. |...|..|...|||||||..   ... .| ... .  .             .|.||.|||||||||||||..|... 
vlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm

LEQAkrEGVVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVLETVMCGD
||.   ||.||.  .|. ||.||.  .||.|.||.||....|| ...|.
lell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk

0042113 (Phosphotyrosine protein) phosphatases II 6-229 7.5e-70 230.4 In-house 22-241 (245) alignment
Range on Protein: 6-229
Range on HMM: 22-241/245.0
DDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiAENYNFGPFTVTLTNEQ
|..|..|.| .      ..| ||||.|||    ||||.|||...|. ||||..|...  .|||.|.. |  . ||.||||.   | ...| |||||..|.
dhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllsee

VYPDFVIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS-PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVN
...|...|.|.|.  .|.. |.. ..|| ..||||||||.   | .... |    . .|.||.||||||||||||||||....|||...|. |..  .| 
hlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavk

RLRQQRMKMVQTLDQYVFLHDAVLE
.||.||...|||..||.||..|.||
elrsqRpgavqtpsqyrflyealle

subfamily_PTPN12_pd Subfamily PTPN12 6-231 5.3e-69 227.3 In-house 53-277 (290) alignment
Range on Protein: 6-231
Range on HMM: 53-277/290.0
DDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
| .|..|.   . .  .  | ||..| | ......||.|||. ||| ||||.||. .   .||. .. |  | |||.|||..  |. .||.|.|||..|.
dksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

VYP-DFVIRQLNVKIYdgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGV---VDIAG
    ||.||.|.|.     ..|....|.| |.|||||||  |..|..| ..|  . . .. |..|||||||||||| ||||.. |. |.| .   .|.  
avdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfd

IVNRLRQQRMKMVQTLDQYVFLHDAVLETV
.| .||.||  .||| .||.... ||.| |
lvlelrkqraalvqtkeqyelvykavaelv

0037934 (Phosphotyrosine protein) phosphatases II 6-229 2.6e-68 225.5 In-house 23-240 (243) alignment
Range on Protein: 6-229
Range on HMM: 23-240/243.0
DDNRIVLtpwpqlDKcqTTYTNASYIDGYSnrtKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPntiaENYNFGPFTVTL
|..|..|      .   . | ||..|...    ..||.|||...|. |    |||..|...  .|||.|.|.| .. ||.||||    .....|.|||||
dhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gevtygdftvtl

TNEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--------WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkr
..|....|...| | .. .| .. ... ..|| ..||||||||  ..|......| .           .|.||.|||||||||||||.||... |..   
lseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll..

eGvVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVLE
 | ||.  .|..||.||.  .|||..||.||..|.||
.g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-267 3.6e-67 221.8 In-house 61-324 (325) alignment
Range on Protein: 6-267
Range on HMM: 61-324/325.0
DDNRIVLTPwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN
| .|.||    . |. .. | ||||.  . ..  |.|.| |. .|. |.|||.  |.    |.|.|.|  .. | .| .|||. ...  .||.. | |  
dksrvvlet..kkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrt

EQVYPDFVIRQLNVKIYDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------ATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVV
 . . |.| |.|.||  ..  .. .. |..| ||.| ||. . . |.|. . |        . . . .||||||||||||||.||..  ||..   |  |
ieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrv

DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
|| | |..||..| .||.| |||.....|. |..|.|.|..  . .| ||  |.| .  |    .. .|.
difgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 6-241 5.7e-67 220.6 In-house 46-276 (283) alignment
Range on Protein: 6-241
Range on HMM: 46-276/283.0
DDNRIVLTPWPQldkcqtTYTNASYID---GYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENynFGPFTVTLT
| .|. | . ..      .| ||..|     | .  |.|..|.|...| ||||.....|| ..|||.|.|.|. . || ||||.  .|.  .|.||||| 
dqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed..yGeftvtlr

NEQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGI
.|     |.|..| ..    ....  |. | .  | . |       |. . | .       ||||.||||.|.|||..|||.  ....|. | |||.  .
kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfav

VNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILAN
|. .|.||| .||||||| ..|..|||  .||||.| | 
vkimreqrmmavqtldqyklvhelvleqalcgdtqiaav

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 6-232 2e-66 219.0 In-house 54-277 (281) alignment
Range on Protein: 6-232
Range on HMM: 54-277/281.0
DDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAeNYNFGPFTVTLTNEQ
|  |...||    .. .| | ||....||.. ...||.|||. ..||.||...|..|   |||||.  |. | || .|||.  . . ..| .||. |.|.
Datrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaee

VYPDFVIRQLNVkiYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS-KGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIV
  . .. |....  .  |... ...| . |.|||||||. .. |.. .|.|. . ... | |...|||||||||||.||.| .......|   .|.  .|
ekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavv

NRLRQQRMKMVQTLDQYVFLHDAVLETVM
. ||..|. ||||. || |.. |||....
aelrkernlmvqtvvqyefvykavldald

subfamily_PTPN9_pd Subfamily PTPN9 6-230 3.8e-64 211.5 In-house 55-289 (297) alignment
Range on Protein: 6-230
Range on HMM: 55-289/297.0
DDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQ
|. |.||.  .  .. .. | ||...||| ..  ||| |||.|||  ||||..|... . |||.| . |  . || ||||..  .  .|| ..|.  . .
detrvvlakvd..edeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve

VYPDFVIRQLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM-----------AT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAK
.. |...|.|..|  .  ..| ..| . ..||||.|||. |. |. . ..|            ..    ||. ||.||||||.|||||||..||.|.. .
eeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle

REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
..|.||.   |..||.||  ..|| .||.| . |||| 
evgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_PTPN6_pd Subfamily PTPN6 6-228 4.8e-64 211.3 In-house 67-294 (306) alignment
Range on Protein: 6-228
Range on HMM: 67-294/306.0
DDNRIVLTpwpQLDKCQTTYTNASYIDGYS--NRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnFGPFTVTLTN
|..|..|.   . .  ...| ||.||.. .  .....||.|| ...|. ||||..|||.   |||.|.  | .|.|| .|||.. ...  .|  .|| ..
Dhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvs

EQVYPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK----GPILVHCSAGVGRTGTFIAIDIALEQAKREGV---
|.   |...|.|.|.  . ....... ||| .||||||||     .... ..| .  . ..    |||.||||||.||||||| ||| |.. ...|.   
eksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
.||  .|. .|.||  .||| .|| |.. |. 
idiqklvksvreqrsglvqteqqykfvykaik

subfamily_CG7180_pd Subfamily CG7180 6-235 9.6e-54 177.0 In-house 55-294 (296) alignment
Range on Protein: 6-235
Range on HMM: 55-294/296.0
DDNRIVLTPWPQLDKcqTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIaeNYNFGPFTVTLTNEQ
| ||.||.     .|  . | ||.|.|..    ..|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .||||.   . ..|.. | ...|.
DynRvvLekldGeek..sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveek

VYPDFVIRQLNVKIY---------DGSNDSHTLTQYHLTSWPD-HGVPDYATPLMSLHKQVMA---TW--SPSKGPILVHCSAGVGRTGTFIAIDIALEQ
 |....||.. ..           . . .  ......|| |.  . ||  .. |. | ..|          | .||..|..| |..|.| ..|||..||.
qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlel

AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
...|. ||. . | .||..| ..|.. ..| .. | .|| |.|. 
vekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_PTPRN_pd Subfamily PTPRN 6-231 2.1e-50 166.1 In-house 69-292 (297) alignment
Range on Protein: 6-231
Range on HMM: 69-292/297.0
DDNRIVLTPwpQLDKCQTTYTNASYIDGYSNR-TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFgpFTVTLTNE
|..|. |.   . .. .. | ||| |     | . .||.|||. .|. |||...|..  | ||..|.|.|   ..|..|||.. .| |..  . | |  |
dhsrvklke..easaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi..yevhlvse

QVYP-DFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGI
 ..  |...| . .|  .  ... |.||.|  |||..|||  | .|. . ..|  ..     ||.||||.|.||||..|.||. |.. ..    .|||  
hiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaat

VNRLRQQRMKMVQTLDQYVFLHDAVLETV
.. ||.|| ..|.| ||. |   || | |
lehlrdqrpglvktkdqfefaltavaeev

subfamily_PTPN14_pd Subfamily PTPN14 6-229 7.4e-49 161.4 In-house 62-294 (300) alignment
Range on Protein: 6-229
Range on HMM: 62-294/300.0
DDNRIVLTPWPQLdkcQTTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNT--IAENYNFGPFTVTL
.|||. |.|  .    .| | ||| |     ... ..|..|||...|. |||...|...   |||.|. .|. | |. .|.|..   ... .|| | || 
ednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt

TNEQVYPDFVIRQLNVKIYdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSL-------HKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAK
   .  . .. ..|..|    |..  |.     | |||||||.  .. .|         ...  . .   || |.||||||||||||  |  |. ..  .
kfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatle

REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 . ..||  ...|||.||| .|||| || |.......
hneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 6-228 2.1e-48 159.6 In-house 51-274 (287) alignment
Range on Protein: 6-228
Range on HMM: 51-274/287.0
DDNRIVLTPWPQLDkcqTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTL-TNE
||.|..|.  ..|    . | || |. .| .  .|||.|||.  |. ||||......  |....|   | .. || .|||.        | ..|.|   .
ddtrvllsaegelG...sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldyd

QVYPDFVIRQLNVKIYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-----MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDI
.  |.. .| | .   .. .... . |..| ||||....  |  |. .  .|     .|  .   ||..||...|.||.|...|. . ... .  | ||.
ikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdv

AGIVNRLRQQRMKMVQTLDQYVFLHDAVL
| .| |||..|  .||.  |. .| .|. 
aavvirlreyraalvqavvqlrllyealv

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 6-232 4.7e-40 132.5 In-house 54-278 (307) alignment
Range on Protein: 6-232
Range on HMM: 54-278/307.0
DDNRIVLTpwpqLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFG--PFTVTLTN
| .|||..    .|   . |  | |.    .  |||..|||...|  .|| .. |||  |..|. .. | .| |||||||    ..  ||  | |....|
dkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan

---EQVYPDF-VIRQLNVKIyDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAIDIALEQA-KREGVVD
   ... ||  .|   ..|. | ...| |....  . |||.|||.     . | . |       . |..|||||||||.|| .|| .  ..  . .   |
lgakklapdedlinvttlkv.dwaqksrtiqhlqwenwpdrgvpqinltainlleav....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd

IAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
.  .|. ||.||   .||  ||..||  .||  .
mkklveelrsqrhyaiqteaqylylhrvlleyfl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 6-230 1.5e-37 124.0 In-house 61-286 (305) alignment
Range on Protein: 6-230
Range on HMM: 61-286/305.0
DDNRIVLT-PWPQldkcqtTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGP--FTVTLT
|.||. |  |||        |  | |.   .|  .|| .| |..||  ||| . .|.|  .| |. ||.|    || .|..    .  .|      ... 
dnnrvklegpwph......eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvk

NEQV-------YPDFVIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG
 |           . ....  . |    ....  |.||   ||| |||   . .. | ..      |||||| ||||||.||||. . ..  |.|     
fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagq

VV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
.. |   |....|.|| . .|| .||.|.|. .|. 
iiedtdkilqkireqrnnsiqtdaqylfvhqvilny

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 6-70 8e-07 22.9 In-house 50-117 (347) alignment
Range on Protein: 6-70
Range on HMM: 50-117/347.0
DDNRIVLTPWPQ----LDKcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
|. |.||.|        |.   || |||.|     ....| .| |. .|. |||...   |   .| . 
datrvvlspeksknsradd.vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 7-229 2.6e-64 212.0 In-house 42-266 (274) alignment
Range on Protein: 7-229
Range on HMM: 42-266/274.0
DNRIVLTPwPQLDKCQTTYTNASYIDGYSNRTK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE--NYNFGPFTVTLTN
  |..|..  . .. ...| || || ||....| ..| |||. .|. ||||.|.||.   |||.|.|||  ..||..|.|...    . ..| . .. ..
nsrvlles.essededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvek

EQVYPDFVIRQLNVKIYDGsndSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS---KGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIA
     |. .|.| .|       ..... |  |.|||| .|| |..|..| ..|  . . .    .|..||||||.|||| ||||.||. | ..|.|||. 
iverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

GIVNRLRQQRMKMVQTLDQYVFLHDAVLE
.||  ||..|  |||| .|| ..| |. .
kivcnlrldrGGmvqtseqyelihralcl

0049772 (Phosphotyrosine protein) phosphatases II 7-229 7e-37 123.2 In-house 59-278 (314) alignment
Range on Protein: 7-229
Range on HMM: 59-278/314.0
DNRIVLtpwPQLDKCQTTYTNASYIDGYsnrTKFIASQGPMKKTLVDF----------WRLI--WQEKPVSIVM---------------------VTNLK
||| .|   | |.   . | ||||.||.    ||||.|||.. |.|||          ||..  .. ..  |||                      ..| 
dnrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllild

EGTKSKCEQYWPNTIaenynfgpftvtltneqvypdF-------VirqlnvkiydgsndSHTLTQYHLTSWPDHGVPDYATPLMSLhkQVMATWsPSKGP
...   .......                               .              ...  .|. . .||...|. .  .  |  ... .. . .||
gngneptaadlellk.....................eelydpelf..............erlgikylripvpDgsaplledfdefl..efieea.dkggp

ILVHCSAGVGRTGTFIAIDIALEQAkreGVvDIAGIVNRLRQQRM-----KMVQTLDQYVFLHDAVLE
.||||.||.||||||..... . .    || ... .....|..|.      ....|.||.| ..|.||
vlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 8-118 2.2e-14 47.6 In-house 208-312 (440) alignment
Range on Protein: 8-118
Range on HMM: 208-312/440.0
NRIVLTPWPQLDKCQTTYtnASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNTiAENYNFGPFTVTLTNEQVY
.|.    ||.    ..       ..|||..  |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   .    ||||||     .  
erveqiqwpnphtdkspl..qqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvn.trsvtfgpftvghkgsenm

PDFVIRQLNVK
    .| |..|
nrvkvrtlelk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 8-80 5.9e-08 26.6 In-house 49-118 (332) alignment
Range on Protein: 8-80
Range on HMM: 49-118/332.0
NRIVLTPwpQldKCQTTYTNASYIDGYSNRTKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
.|. |.|  |    .  . |||..||||... .| .| |.. .|   |||.. . ||  |... .. |  | |.
srvelap..q..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 9-244 2.4e-60 199.3 In-house 64-292 (439) alignment
Range on Protein: 9-244
Range on HMM: 64-292/439.0
RIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKskceqYWPNTiaENYNFGPFTVTLTNEQVYP
|..|   | .   .. | || ||.|| .   .||.||| |.|  |||||....| | |||.||| |  |     |||    ..  .|  .|    .   |
rvtlqeipgvp..hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielp

DFVIRQLNVK-IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRL
..||| ..|    | ..  .|. |.| ..|||. ||  |. .. . . .  |  .   ||..|||||||||||| ||.|||||| | |  ||| |||. |
nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvl

RQQRMKMVQTLDQYVFLHDAVLETVMCGDTEILANEYE
|.|| .|||.| ||||...|||| .. ||. .. .|..
rkqrkqmvqalcqyvfiynavledivyGdiavtidefk

0044763 (Phosphotyrosine protein) phosphatases II 14-229 1.1e-35 118.2 In-house 9-169 (178) alignment
Range on Protein: 14-229
Range on HMM: 9-169/178.0
PWPQLDKCQTTYTNASYIDGYsnrtKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAenynfgpftvtltneqvypdfvir
 ..  . . . |.|||.|...     ...|..|     .|...|.....  .||..|. .|. . || .|||                            
lsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag........................

qlnvkiydgsndshtlTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQakreGVvDIAGIVNRLRQQRMkM
                 ||. . .|||||||    .. ... . .  ....||.||||||||||.||..|... ...    |. ..  .....|..|. .
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i

VQTLDQYVFLHDAVLE
|.. .|. .|..  |.
vpnpgqlrqLyefelr

subfamily_PTPN3_pd Subfamily PTPN3 17-231 1e-58 193.5 In-house 59-275 (280) alignment
Range on Protein: 17-231
Range on HMM: 59-275/280.0
QLDKCQTTYTNASYID----GYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtIAENYNFGPFTVTLTNEQVYPDFVI
.|.. .| | ||.|..    . .  ...||.|||..||  |||...|..|   |||.|.| |  . || ||||.   .. ..| |.|....|.    .|.
klkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvl

RQLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMK
|.| .|  . ........|   ..|||||||| .. .... ..| .. | .. |..||||||.|||| .|....||    ..  | .  || ..|.||. 
relvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqram

MVQTLDQYVFLHDAVLETV
.||| .|| |. .|.|.  
lvqtasqykfvCeailkvy

subfamily_PTPN1_pd Subfamily PTPN1 17-236 1.2e-47 157.0 In-house 50-278 (290) alignment
Range on Protein: 17-236
Range on HMM: 50-278/290.0
QLDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIA-ENYNFG--PFTVTLTNEQVYPDFVIR
.|.. .. | ||| ..    . ..| .|||. .|   ||...|..|  ..||. .. |  . || ||||.    ..  .    ..|.| .|...  ...|
kleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvr

QLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE---GVVDIAGIVNRLRQ
.|...    ..........| |.||| |||.  . ....  .|    . |. .|| ..|||||.||.|||. .|  | . ...     |||   .  ||.
llelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrk

QRMKMVQTLDQYVFLHDAVLETVM--CGDT
.|. ..|| ||  | . |.|| .    ||.
yrlGliqtadqlrfsylaileGakvikgds

subfamily_CG42327_pd Subfamily CG42327 17-159 1.4e-24 81.4 In-house 50-193 (319) alignment
Range on Protein: 17-159
Range on HMM: 50-193/319.0
QLDKCQTTYTNASYIDGYSN-RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN--TIAENYNFGPFTVTLTNEQVYPDFVIR
. |. .. | .|||. || . .. .||.| .....  ||||..|. .   || .|.| |    .| .|.|   |  ..  .| . ||| . .|   ..| 
igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryais

QLNVKIYDGSnDSHTLTQYHLtSWPDHGVPDYATPLMSLHKQVMAT
 | .|  |..  |  || |    |.. .||   ..|...  .| ..
tlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevrss

subfamily_PTPRB_pd Subfamily PTPRB 18-232 1.1e-79 262.5 In-house 74-286 (293) alignment
Range on Protein: 18-232
Range on HMM: 74-286/293.0
LDKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIaENYNFGPFTVTLTNEQVYPDFVIRQLNV
 |. .. | ||.||.||. . .|||.|||. .|. ||||..|..|   |||.|.| |. | |||.|||..  |. ..|  .|||..|... |.|||.|..
kdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelki

KIydgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW--SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQ
.    ........||| |||||||||. ...|... ..|  .   . ||.||.|||||||||||||||.|  |.. ..| .|||.||| .||..|. .||
ek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvq

TLDQYVFLHDAVLETVM
| .||.|.|..||. ..
tekqYifihqcvldllr

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 18-228 1e-31 104.7 In-house 73-287 (310) alignment
Range on Protein: 18-228
Range on HMM: 73-287/310.0
LDKCQ-TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNT-IAEnyNFGPFTVTLTNEQVyPDFVIRQL
.|| .   |  | |.     |. || ||||...|..||||.|.||.  ||... .  |  . ||  |||   ..|   .|   ||  .|    .| | .|
idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte..tygcirvtnlsess.eefeicnl

NVKIYD-------GSN--DSHTLTQYHLTSWPDHGVPDYATplMSLHKQVMATWspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRL
 | .              .   ..  .   ||| ||||      .. ....|     .|| .||||||..|... .|.........|   ||.  ..  |
avtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktel

RQQRMKMVQTLDQYVFLHDAVL
...|.. .||  ||....   .
lksraiciqtelqyliidrvri

subfamily_PTPRK_pd Subfamily PTPRK 19-266 4.6e-80 263.8 In-house 67-312 (314) alignment
Range on Protein: 19-266
Range on HMM: 67-312/314.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAEnynFGPFTVTLTNEQVYPDFVIRQLNVK
.  .. | ||..||.| . ..||. |||...|. |||||...|.  ||||.|.|.| .. || .|||.       .|.. |.| . ..  ..|.| ..|.
gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrve

I-YDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
    | .. ... |.. ..||||.|| .|| |..| ..| ..  ...|.|.|||||| ||||||||||| |. ..||||||.  .|  ||.... ||.| 
klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete

DQYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQF
.||.|..|..||...||.| | . |..    | ...|. |  | |. .|
eqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 19-302 4.3e-76 251.1 In-house 67-349 (515) alignment
Range on Protein: 19-302
Range on HMM: 67-349/515.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVk
|. .  | ||||| .. |   .|||||| | .. |||||..||..  |.|||.|||| |.|| .|||.  ..  .|| . | |   .   . ..|.|.| 
dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.

iYDGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
   |.. |.|.||.|.| |||.|||  .. |. | |.| |  .  . |...|||||||||| .|.||  . .||   .||.  .|. .||.|...||| .
.lkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

QYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCDSAKAH--SDKNRSTSYLPRENF
|| |...|||| ..  .| |    .  .||.|.      | | .  .|. |  ..|||    . |....    |||  . || .  
qyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrn

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 19-267 4.4e-72 237.6 In-house 68-313 (315) alignment
Range on Protein: 19-267
Range on HMM: 68-313/315.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLnvk
|. .  | ||||| .. .   .|||||| | .. ||||...|||. .|||||...|| | || ||||.  |.  .|| . |.| . .   | |.|.|   
dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...

IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
.   |..|.|.||...| |||.||.  .. |. | |.| |   . . ..|||||||||||| .|.||  ..|.||. .||.  .|. ||..|...||| .
vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqtee

QYVFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
.| |..||||| ..  .| ||   .  .||.|.   . .| | .  .|.
eyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefe

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 19-243 3.5e-62 205.2 In-house 75-296 (297) alignment
Range on Protein: 19-243
Range on HMM: 75-296/297.0
DKCQTTYTNASYIDGysNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIAENynFGPFTVTLTNEQVYPDFVIRQLNVK
|. .  | |||.. |  |. ..|..| ||| |. |||.....|..  |||.....|..| || .||...   .  ||  .|.|.  .    |. |.|.|.
ddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevt

IYDgSNDSHTLTQYHLTSWPDHGVPD--YATPLMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQ
  . .   . . ||. ..|||. |.    |. |. | ..|  ..|  .  |.||||.||||||| ...||  . .||||  ||| |.|..|||.|...||
kgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvq

TLDQYVFLHDAVLETVMCGDTEILANEY
| .|| |.. ||||.... ||.| |. .
tkeqykfvyvavleallsedtriqasyf

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 19-229 5.8e-60 197.6 In-house 44-262 (270) alignment
Range on Protein: 19-229
Range on HMM: 44-262/270.0
DKCQTTYTNASYIDGYSN-RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE--NYNFGPFTVTLTNEQVYPDFVIRQL
.. .|.| || |. |... ..|.||..||.. || .|||.||.||  .|||.|.|.|  ..|||.|||.   |  ....|  .|. ..|.    .....|
edsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrl

NVKiYDGSndSHTLTQYHLTSWPDHGVPDYAT------PLMSLHKQVMATWSP-SK-GPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLR
... ..|.  .. |. .. ..|||||||  .        |... ..| .. .  .| .|.|||||||||||||.||.|||..  .... ||.. |...||
rle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelR

QQRMKMVQTLDQYVFLHDAVLE
..||..||. .|| ||. ||.|
kdRmalvqhpeqyeflykavve

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 19-252 1.6e-50 166.6 In-house 69-257 (392) alignment
Range on Protein: 19-252
Range on HMM: 69-257/392.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskceqywpntiaenynfgpftvtltneqvypdfvirqlnvk
|  .. | |||||... |   .||||||   .| ||||...||.. .|.|||.||||                                           
dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................

iydGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
     .| .| .|.|.| |||..|| ... |. . |.| | .     |...||||||||||  |.||  . .||.  .||.  .|  .|..|  |||| .
...kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtke

QYVFLHDAVLETVMCGDTEILANEYEMKLQELKE
|| |.. |||| ..  .| |    .  .||.|. 
qyafiygavledllwrntlipvvhftdhlqdlst

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 19-229 4.2e-46 151.9 In-house 77-281 (290) alignment
Range on Protein: 19-229
Range on HMM: 77-281/290.0
DKCQTTYTNASYIDGYsnRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVI-RQLNV
|  .  |  | |..|   .. || .||..|.| .|.||.. |||   |||. .| |  |.|||||.|..  |   || .||. ..|.   . .| . | |
dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsv

KIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
.  | |  .| |  ... ||||. |.  .  |. . . .        ||. ||||||.||||||.||...|.       .|....|  ||. |.. ||  
rdkd.sGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvd

DQYVFLHDAVLE
 ||. | ...|.
iqylalveilld

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 19-229 3.1e-37 122.8 In-house 62-267 (281) alignment
Range on Protein: 19-229
Range on HMM: 62-267/281.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVK
.|  | |  | ||     .  .| .||| |.|  ||||.||||.  .|||. .. |  . || .|.|       .|  ..|.  .  |   .|  .||. 
nknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls

iYDGsnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPskgpILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQ-QRMKMVQT
 |.|  ... .|..    |||  ||. .  .. . ... |  .|     ..||||||||.||..|..|||.  .    . ||  || .||   |   |||
.yeg..etrlithwlwkewpdwqvpessevmlkilrkirarstp....pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqt

LDQYVFLHDAVLE
|.||...   .|.
lqqymliwkvlld

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 19-232 7.7e-37 121.9 In-house 64-272 (288) alignment
Range on Protein: 19-232
Range on HMM: 64-272/288.0
DKCQtTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVK
| ..  | .|  .    .. ..| .| |.. |.  .|... ..    |||...| |  | | ..|.|  . |.  .| .     ....  | ...   ..
ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllr

IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
|    ...  . . ||  |.|.|||.   . . | . .       . ||.||.|||||||||.| | ||||... .  . |  ....||..|.| .||  
iskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem

QYVFLHDAVLETVM
||...|  ||| ..
qylyvhrcvleell

subfamily_ptpA1_pd Subfamily ptpA1 19-188 1.9e-32 107.5 In-house 71-253 (418) alignment
Range on Protein: 19-188
Range on HMM: 71-253/418.0
DKCQTTYTNASYIDGYSNrTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAE---------NYNFGPFTVTLTNEQVYPD
||  . | || ||||     .||..|||. .|. ||||..|...   |||..   |  . ||..|||. |           |  || ..| | .    |.
dkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe

FVIRQLNVKIYDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------ATWSPSKGPILVHCSAGVGRTGTFIAIDIAL
  |   |...     ... .|||.   |||| .||.. |.  | . .          |  . ||.||||||||||||| .  | .
reiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 19-228 2.3e-23 77.1 In-house 71-282 (302) alignment
Range on Protein: 19-228
Range on HMM: 71-282/302.0
DKCQTTYTNASYIDGYSNRTKFIASQGPMKKTL---VDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFViRQL
....  | ||| ..  . . . | .| | ...     .|||...||| ||.|..   .| .|   ....|..  .  ..| . |     .   . .  ..
eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.try

NVKIY-DGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMV
 . .  .|  .|   . |.|| |... ||.  . |.   ..| |  .... ....    |.|| |.|..  .|.|. ...  . |. ||. .|.|| ..|
viEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

QTLDQYVFLHDAVL
..|.|||.|. |.|
dslkQyvslyiall

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 20-230 3.4e-74 244.5 In-house 72-278 (288) alignment
Range on Protein: 20-230
Range on HMM: 72-278/288.0
KCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTLTNEQVYPDFVIRQLNVKi
. .. | |||||||. .. |.||.|||. .|. |||.|....|   |||.|.| || |.|||.|||..  .. |.| .||||....   ||| |.| .. 
eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle.

ydGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
   ...  ..|||. ..|||||||. ..||. | .||  . .   |||.|||||||||||||||.| .... ..| ..|.||.|..||.||. .|||| |
..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkq

YVFLHDAVLET
|.|.....|. 
Yefiyevllsl

subfamily_eak_pd Subfamily eak 20-154 1.5e-10 35.0 In-house 75-205 (332) alignment
Range on Protein: 20-154
Range on HMM: 75-205/332.0
KCQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKI
. .  | ||| ..      |.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|.   |...|| . |.  .      .  |.| .. 
lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelsk

ydgSNDSHTLTQYHLTSWPDHGVPDYATpLMSLHK
    |..| .  |..  | .  .| |   ...|.|
...GnethrvlhykvfGwtettlpkyed.flalrk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 21-267 1.2e-78 259.3 In-house 75-315 (315) alignment
Range on Protein: 21-267
Range on HMM: 75-315/315.0
CQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaeNYNFGPFTVTLTNEQVYPDFVIRQLNVKIY
 .. | ||..||||. . ..||.|||   .. |||||...|.   |||.||| || |.|.|.|||.    .  .|..|||. .|.|. .. .| | |   
phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfg

DgsnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
|   . ... |.|.||||| ||| |..||| |...|.     | |.|.||||||||||||||..|  |.||. | ..|.  .....||.|.||||...||
d...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy

VFLHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFD
 |..||.|||..|||| |  . |  . . |      || . || ||.
qfiydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeqfe

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 21-229 1.5e-58 192.8 In-house 27-237 (237) alignment
Range on Protein: 21-229
Range on HMM: 27-237/237.0
CQTTYTNASYIDGYSNR-TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTLTNEQVYPDFVIRQLNVKI
... | ||.|..|.     |.||.|||.. .  |||...||||   |||.| | || . || .|||.|  .   .| .||.|. .. . |. .| | .  
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkeefsdytvrslllsk

YDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
    ..   . ||..|||||.|||.... |. . |...      .  || ..|||||||||| |. ||  | ||| . ||||   |  . ..|  ..|| 
rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtk

DQYVFLHDAVLE
|||||.|...||
dqyvfihqtile

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-230 6.9e-41 135.0 In-house 55-258 (267) alignment
Range on Protein: 21-230
Range on HMM: 55-258/267.0
CQTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtksKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKIY
 .  | ||||..||  . .||. |.|.|.|  ||. .| ..|   ||..|.  ..   .  ..||  ...  ..  .||  . |.   |. |  |..|. 
keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk

DGSndSHTLTQYHLTSWPD-HGVPDYATPLMSLHKQvmATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
. |  .| .| |.   |        |  ||. .  .          |..|.||.||||.|||. ||  ||.||.|||.||   . ..|.||. .|.|...
nes..ahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtker

YVFLHDAVLET
|...|. . | 
yiyihellaey

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 21-248 3.1e-29 97.0 In-house 44-267 (290) alignment
Range on Protein: 21-248
Range on HMM: 44-267/290.0
CQTTYTNASYIDgYSNRTKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNTIAENYNFGPFTVTLTNEQVYPD
 .  |  |...  ..|  ..|..| | .|.       . .|| .. |||  ..||. . .| ..      |..| |... |. .|. .||  ..     |
fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

FVIRQLNVKiYDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQAK-REGVVDIAGIVNRLRQ
. .|.| || .|. .  .|.| . | .| .  |..    |.|| ..|.|    || |..|||  |. |  .. ||...       .| | .. ... ||.
vetRelvvk.fdd.eeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRMKMVQTLDQYVFLHDAVLetvmcgdteILANEYEMKLQ
|| .....  .. |   ...         .|| |  ..  
qralaitsalelafvdagiv.........llaievldqfa

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 21-156 5.7e-25 82.8 In-house 57-193 (297) alignment
Range on Protein: 21-156
Range on HMM: 57-193/297.0
CQTTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNE---QvYPDFVIRQL
 .. | || |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||..  |. . | . |    .   . .   .. .|
terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltel

NVkIYDgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV
.. ||   ..|  ..     ||||||||     |  .. ||
ql.iyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 21-233 1.6e-12 41.6 In-house 67-281 (303) alignment
Range on Protein: 21-233
Range on HMM: 67-281/303.0
CQTTYTNASYIDGYSNrTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiAENYNFGPFTVTLTNEQvyPDFVIRQLNVKIY
....|  |||..  |.  | | .| |. .|  |||..| ..|   ....    |  |   .  .|.   .  .|   .. . . .     .    ..|. 
sdssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkfeersirvgefk..rvelgdgwvlkvl

DGSNDSH--TLTQYHLTSWPDHGVPDYATPLMSL----HKQVMATWSPSKGPILVHCSaGVGRTGTFIAIDIALE-QAKREGVVDIAGIVNRLRQQRMKM
  || ..   |  .|  .||   .|  ..| .       . |.  .|.|. .. .  | |.||.|||  .. |     . .  .|.   .. .|. |.. 
svsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfetahlslhseqasldlvkclenvrngrlha

VQTLDQYVFLHDAVLETVMC
|| | |. ...  . | |. 
vqnlsqfsvvytllaehvld

0041856 (Phosphotyrosine protein) phosphatases II 22-236 2.8e-46 152.8 In-house 18-176 (182) alignment
Range on Protein: 22-236
Range on HMM: 18-176/182.0
QTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPntiaenynfgpftvtltneqvypdfvirqlnvkiyd
  .| ||....|.   |.||| |||...|. ||.|......  .||..|         .|.|||                                    
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................

gSNDSHTLTQYHLTSWPDHGVPDyATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQakreGvVDIAGIVNRLRQQRMKMVQTLDQYV
 ..  .. .||. ..||||||||    | .. ..| .    ..||.|||||||||||||..|... ...    | |..  .|. .|..|..||.|..||.
.ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyf

FLHDAVLETVMCGDT
||..|.|| .....|
flqlallellllkkt

0046846 (Phosphotyrosine protein) phosphatases II 22-229 7.7e-43 141.6 In-house 11-171 (176) alignment
Range on Protein: 22-229
Range on HMM: 11-171/176.0
QTTYTNASYIDGYsnrtKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYnfgpftvtltneqvypdfvirqlnvkiyd
  .| ||..|.|.    ..|| |||. .|| ||........   .|..|...|  . || .|||   ....                             
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

gsndshtltQYHLTSWPDHGVPDYaTPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDialeQAKREGVVDIAGIVNRLRQQRM-KMVQTLDQY
         ||. . ||||||||. . |..| ...   .  ..||.|||||||.|||||..|..      ..|  ...  .. ..|.||. ..||| .||
.........qylhlpwpDhgvpdl.elllellefire.alkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

VFLHDAVLE
 ||....|.
rflyefell

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 22-142 7.5e-13 42.6 In-house 121-235 (244) alignment
Range on Protein: 22-142
Range on HMM: 121-235/244.0
QTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDfvIRQLNVKIYD
  || |||..      ...| .| |.  | .|||...  |. | ...|     |.  . ..|||..   ..     |||||. . . .  |.  |..|  
gntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpdseplewyeeditvtltdrdefkn..ikasnleies

GSNDSH-TLTQYHLTSWPDHGV
  |.|| .|| . .. ||  | 
dmneshqaltmfqisnwpsdgt

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 22-142 3.5e-09 31.1 In-house 12-126 (130) alignment
Range on Protein: 22-142
Range on HMM: 12-126/130.0
QTTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDfvIRQLNVKIYD
. || |||..    . .... .| |. .| .|||...  |. | ...|     |.  . ..|||..   ..     .||||. . .    |.  |..| .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvl....gsveeedeywpdsePlewyeediivtltdrdefkn..ikasnleies

GSNDSH-TLTQYHLTSWPDHGV
  |.|| .|| .... ||  | 
dlneshqaltmfqisnwpsdgt

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 23-251 3.4e-68 225.3 In-house 89-311 (319) alignment
Range on Protein: 23-251
Range on HMM: 89-311/319.0
TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYpdFVIRQLNVKIYDG
. | |||...|| .. |.||.|||.. || ||||.||. .  .||..|      | || ||||. | .... .   |.. .|     .|.|....     
sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgk

SNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
 .|   .||.|.  |||.|||||...|| | |.|         . .|.|||||||||||..|..|. |.. |.|  ||.  .|. ||||| ..|| | ||
ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFLHDAVLETVMCGDTEILANEYEMKLQELK
 |.. |.||  . | ...   ..   |.|| 
kfiysalleehlfghsdvampdfpayleels

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 23-251 2.7e-67 222.3 In-house 53-275 (284) alignment
Range on Protein: 23-251
Range on HMM: 53-275/284.0
TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYpdFVIRQLNVKIYDG
. | |||.| || .. |.||.|||.. || ||||.||. .  .||..|      | || ||||. | .... .   |.. .|     .|.|....     
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgk

SNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
 .|  ...|.|.  |||.|||||...|| | |.|    .    . .|.|||||||||||..|..|. |.. |.|  ||.  .|. ||||| ..|| | ||
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

VFLHDAVLETVMCGDTEILANEYEMKLQELK
 |.. |.||  . | ...   ..   |.|| 
kfiysalleehlfghsdvalpdfpayleels

subfamily_PTPN13_pd Subfamily PTPN13 23-230 6.2e-58 191.2 In-house 60-268 (273) alignment
Range on Protein: 23-230
Range on HMM: 60-268/273.0
TTYTNASYIDGY--SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGP-FTVTLTNEQVYPDFVIRQLNVKI
..| |||.|      .. ..||.|||. .|  |||...|. |   |.|||. ||. | ||..|||..  ..      ..|.| . | . .||.|.|.|| 
ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd

YDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
 . |..|. ... ....|||||||  |..|. . .. ...   ..|||.||||||.||.||.|.||..|.  .|.  .|.  ||..||.||  .||| ||
se.sgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq

YVFLHDAVLET
|.| . |.|| 
yifvykailev

0043147 (Phosphotyrosine protein) phosphatases II 23-224 2.5e-43 143.1 In-house 5-154 (172) alignment
Range on Protein: 23-224
Range on HMM: 5-154/172.0
TTYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegtkskceqywpntiaenynfgpftvtltneqvypdfvirqlnvkIYDG
..| ||||.|.|   ..||| |||.  || ||||......   ||..|.|                                               ||.
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SNDSHTLTQYHLTSWPDHGVPdYATPLMSLHKQVMA-TWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreG-VvDIAGIVNRLRQQRMKMVQTLDQY
.. ...  ||. ..|||||||  .  |... ...       ..||.|||||||||||||..|... |        . ..  .|. .|..|...||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

VFLH
 ||.
rfly

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 23-232 3.5e-37 122.9 In-house 59-271 (285) alignment
Range on Protein: 23-232
Range on HMM: 59-271/285.0
TTYTNASYIDGY-SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN--EQVYPDFVIRQLNV-K
  |  ||..     ... .|..|||. .|| |||..|.|||   ..|.  | ||   ||  |.|. . |  .|| . .|||.  |.     ..  | | .
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

IYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLD
  | |..   . . ..  |||.  |. | |.. |.| |     | . || |||||||||| ||. || |  .   .  ...  ||  .|  |.. ||.  
tedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

QYVFLHDAVLETVM
|..||.  ..| ..
qflflyvvlmeyfi

0051082 (Phosphotyrosine protein) phosphatases II 23-228 2.1e-36 120.1 In-house 3-150 (151) alignment
Range on Protein: 23-228
Range on HMM: 3-150/151.0
TTYTNASYIDGYsnrtkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPNTIaenynfgpftvtltneqvypdfvirqlnvkiydg
..|.|.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|..                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sndsHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwsPSKGPILVHCSAGVGRTGTFIAIDIALEQakregvVDIAGIVNRLRQQRMKMVQTLDQYVF
    ..........|||.|.|..   ..........   ...||.|||||||.|||||..|... |..      |... ... .|..|. .||. .|..|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

LHDAVL
.. |.|
qlfall

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 23-230 6.3e-34 112.0 In-house 80-288 (305) alignment
Range on Protein: 23-230
Range on HMM: 80-288/305.0
TTYTNASYIDGY-SNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNE-----QVYPDFVIRQLN
. |  | |.        .||..|||. .|. .|| .. |.|   |||. .  |  | || |||| .  |. ..    |          .  ..  |  ||
sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitlln

VKiYDGSnDSHTLTQYHLTSWPDHGVPDYAtpLMSLhkQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQ-AKREGVVDIAGIVNRLRQQRMKMVQ
.  | |. .. .. . . | ||| |||     | ||  .....   || ||.||||||.||||| .||.  ||. |.   .  .  .|. ||.||   .|
lt.ysgd.qkmsvrhlqwtewpdrgvppck..ltsl..ellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq

TLDQYVFLHDAVLET
.  ||.|.|  .|. 
ndvqylfihrvmlny

0051429 (Phosphotyrosine protein) phosphatases II 24-231 6.5e-56 185.2 In-house 5-225 (272) alignment
Range on Protein: 24-231
Range on HMM: 5-225/272.0
TYTNASYIDGYSN---RTKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NTIAENYNFGPFTVTLTNEQVYPDF
.| ||....|| .   . ....|.||.. |  ||||| ....  .||..... |  . ||..|||          .. |. ...| ..|||. |....|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRQLNVKIYDGSNDSHTLTQYHLTSWPDHGVPDYAtpLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVD--------IAGI
..| | .... . .........| |.|||||||. |  | .| ... .     .||.|||||||..||||..|... |..  .| .||        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VNRLRQQRMKMVQTLDQYVFLHDAVLETV
|..||.||...||| .||.||..|.|| .
veelraqrpgavqteeqylflyeallell

0036282 (Phosphotyrosine protein) phosphatases II 24-225 5.6e-47 155.0 In-house 3-164 (174) alignment
Range on Protein: 24-225
Range on HMM: 3-164/174.0
TYTNASYIDGYSNRTKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNtiaenynfgpftvtltneqvypdfvirqlnvkiyDGS
.| |||..|..   ...||.|||..     ||.......  ..||....||  . || .|||                                   . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

NDSHTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKrEGVVDIAGIVNRLRQQRMKMVQTLDQYVF
  ...  ||. . |||||||| .. | .. |.|    |  ..||.|||||||||||||..|... | . . |..||.  .| .||.||..|||| .|| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LHD
|..
lyy

subfamily_egg_pd Subfamily egg 24-251 1.2e-29 98.0 In-house 69-292 (307) alignment
Range on Protein: 24-251
Range on HMM: 69-292/307.0
TYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYWPNTIAENYNFGPFTVTLTNEQVY--PDFVIRQLNVKIyD
 .  | ...|     .|| .| |.| |  ||||...||.   |||.|  ||    .|| |||.. ...  . | .. ..| .|.  .| . |  ..|.  
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.v

GSNDSHTLTQYHLTSWpdHGVPDYATPLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVV--DIAGIVNRLRQQRMKMVQTLDQ
|..|     ..    .  . . |  .||  | |   .       |..|..  || ...|..||.||| .  |  ..   .   |  ||..|   |..  .
Ggddeerflehwqgdv..nnssdvysplrvlrklrnl.....skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvll

YVFLHDAVL--ETVMCGDTEILANEYEMKLQELK
|.|..  ||     . | .. |  .||  |.|  
ylfvyrlvlfffrdvigsakeldvdyerwleers

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 24-235 2.5e-25 83.8 In-house 68-280 (312) alignment
Range on Protein: 24-235
Range on HMM: 68-280/312.0
TYTNASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIA--ENYNFGPFTVTLTNEQVY----PDFVIRQLNV
 |  | ..   ..  .|...|||...| . ||.|      .||.... . | .  || .|  . ..  .  .   .|   |. ..          | |.|
fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkv

KIYDGSNDShTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTL
 .    ..|  | .|  .||||||.||     . |    ...    | |.. |||||||||||.. |.  .   .     ..  .   ||..| . |...
vvkatgqes.klnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvf

DQYVFLHDAVLETVMCGD
 |||.   .||| ...  
pqyvyalrcvleflyskg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 24-107 1.1e-09 32.1 In-house 91-171 (349) alignment
Range on Protein: 24-107
Range on HMM: 91-171/349.0
TYTNASYID--GYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTiaenyNFGPFTVTLTNEQVY
 | || |.    .|   |.|| | |.  |. ||...|  ..   .. ... || .  ||..|| .      ..  .|| | |   |
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel.....sysnitvklqnssly

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 25-125 1.3e-14 48.8 In-house 85-190 (350) alignment
Range on Protein: 25-125
Range on HMM: 85-190/350.0
YTNASYIDGY----SNRT--KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGpFTVTLTNEQVYPDFVIRQLNVK
| ||.|.       .  .  |.|| |.|...|. ||...| . |   |...|.. |    ||..||..   ....   .. .  |     | ...  .||
YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvk.laskwenimgindsslysadvk

IYDGSND
.    ||
keasdnd

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 27-223 1.7e-35 117.2 In-house 79-273 (301) alignment
Range on Protein: 27-223
Range on HMM: 79-273/301.0
NASYIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFV--IRQLNVKIYDGSN
 | .|.   .  .|||.|||.|.|  ||| .. | .   |||...  | ...|||.| | .|.|. . | |.....|...  .     |.|.|.   |  
hanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkf

DSHTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFL
...|.| |  ..|.|.|||   . |. |    |     |. ||.||||||.||. .||. ..   . . .  ....  ...||..| . |||  |  ..
atrtvthyqysewtdrgvPkshaelfdl....melvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

0049260 (Phosphotyrosine protein) phosphatases II 30-225 1.4e-42 140.3 In-house 1-144 (152) alignment
Range on Protein: 30-225
Range on HMM: 1-144/152.0
YIDGYSNRTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWpntiaenynfgpftvtltneqvypdfvirqlnvkiydgsndshtl
.|||| . ..||| |||.  || ||||.... .   |||.|.| | .| |||||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 ||. . |||||||| .  |. |.. .   .  ..||.|||||||||||||..|... |        |..  .|...|..|...|.. .|. ||..
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 32-232 3e-26 86.6 In-house 84-289 (302) alignment
Range on Protein: 32-232
Range on HMM: 84-289/302.0
DGYSNRTKFI-ASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTN-EQVYPD------FVIRQLNVKIYDGS
||  .. |       | |.||  .| || | .   .| .....|. . || .|. . . .. .|| .||.  . ..   .      |.. ....| .   
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

-NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVF
 .  .|.   . ..||||| |. | . . . |   . .   |  .|||||||||||||..||   ..  ... | |.. ||  .|| |   ||. .| ..
kkvkktvdilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

LHDAVLETVM
|   |  ..|
lllcvtkglm

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 37-224 3.9e-28 93.0 In-house 4-197 (199) alignment
Range on Protein: 37-224
Range on HMM: 4-197/199.0
RTKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKIYDGSND-SHTLTQYHLT
. ..||.| |...|. |||...|.     |||| . .   ..    ||| | .   ..| ..||     . ||..|  | .     .   .  ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 38-224 4.6e-28 92.7 In-house 4-196 (198) alignment
Range on Protein: 38-224
Range on HMM: 4-196/198.0
TKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVYPDFVIRQLNVKIYDGSND-SHTLTQYHLTS
 ..||.| |...|| |||...|.     |||| . .   ..    ||| | .   ..| ..||     . ||..|  | .     .   .  ...| .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 39-261 2.1e-08 27.2 In-house 116-340 (346) alignment
Range on Protein: 39-261
Range on HMM: 116-340/346.0
KFIASQGPMK---KTLVDFWRLIWQEKpVSIVMVTNLKEGTKSKCEQYWPNTiAENYN-FGPFTVTLTNEQVYPDFVIRQLNVkIYDGSNDSHTLTQYHL
|.| .| |       . ||| .|.||. . .| .    .  |      . .     |.  | . .     .|  |     ..| . .|  ||     .| 
klivaqlpqmenesfvedfwymiyqeq.ihlvylmvpddklkntttslfnde.nggyqytgkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhhh

TSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM--
. |     |  . |.. . .| ..     .  . |    | ||. .||    |..|       .|  |.  ..|||   |... ||  ..  |.. .   
apwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiark

-CGDTEILANEYEMKLQELKEIdsSTGCSA
  |  . .  . .  ..|| ||  |  ||.
rggkkapvnkdinrfidelaei..spacsp

subfamily_hpo-7_pd Subfamily hpo-7 48-251 9.8e-19 62.3 In-house 44-244 (263) alignment
Range on Protein: 48-251
Range on HMM: 44-244/263.0
KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNEQVypDFVIRQLNVKIYDG-SNDSHTLTQYHLTSWPDHGVPDYA
 .|.  |.. | | |.  .||... .|  . ||..|.|    |   .   .|. |. |   | ... |..  . |     ||...|  . |...  |  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

TPLMSLHKQVmatwSPSKgPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTeilA
   . . | .      || .. ||||.|.||.  |  ....        .    . .|   ... ||..| . ..|  |  |    ||. |.   .    
reilnilkva....rnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa...k

NEYEMKLQELK
.| | | ||..
geleakyqeir

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 50-251 8.8e-23 75.7 In-house 40-235 (255) alignment
Range on Protein: 50-251
Range on HMM: 40-235/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNTIAENYNFGPFTVTLTNeqVYPDFVIRQLNVKIYDG-SNDSHTLTQYHLTSWPDHGVPDYATP
|.  |.. | | |.  .||.....| .. ||..|.|    |   .   .|| |.     | |.| |..  . |     ||.. |. . |...  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LMSLHKQVMAtwspSkGPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVmcgdteILANE
.. . | |      |  ...||||.|.||. .|. ....        .    . .|   ... ||..| . ..|  |  |    ||. |        ..|
ilnilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkge

YEMKLQELK
.| |.||..
leakyqeir

0048076 (Phosphotyrosine protein) phosphatases II 82-228 2.6e-30 100.3 In-house 1-140 (145) alignment
Range on Protein: 82-228
Range on HMM: 1-140/145.0
QYWPNTIAENYNFGPFTvTLTNEQVYPDFVIRQ-LNVkIYDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSkGPILVHCSAGVGRTGT
.|||. | ..  .|... |  . . . |. |.  ||.  .. .. ... .||. ..|||||||| .  |... ... .  .   ||.|||||||||||||
pywpseilpglylgslp.taldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

FIAIDIALEqakrEGvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
..|... |.    .| |..  .....|.||...|.. .|. ||....|
lvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 83-225 1.3e-27 91.7 In-house 2-139 (144) alignment
Range on Protein: 83-225
Range on HMM: 2-139/144.0
YWPNTIAENYNFGPFTVTLTNEQ---------------VYPDFVIRQlnvkiydgsndshtLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSpSKGPI
..|. | ..  .|.. ..|  |.                .|.|..|.               .||. ..||||||||... | .. . . .  . ..||.
snpseilpglylgslptaldlellkklgittvinlteeyepeflere..............giqylhlpwpDhgvpdllellleflefieeale.eggpv

LVHCSAGVGRTGTFIAIDIALeqakREGvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|||||||||||||..|... .    ..| ...  .....|..|. .|.. .|. ||..
lVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle

0038934 (Phosphotyrosine protein) phosphatases II 111-184 6.7e-10 34.4 In-house 49-135 (194) alignment
Range on Protein: 111-184
Range on HMM: 49-135/194.0
VIRQLNVKIYDGSNDSHTLT------------QYHLTSWPDHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAI
....||||..   . ..| .            .|.   .||.| ||.... |  |.     .   ..| ..||| ||.|||||..| 
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_CDC14_pd Subfamily CDC14 112-185 7.4e-08 26.6 In-house 217-284 (328) alignment
Range on Protein: 112-185
Range on HMM: 217-284/328.0
IRqLNVKIYDGSNDSHTLTQYHltswpDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAID
.| || |.|| ..  ..  ...     |    | .||  .. |. ..    ..| | ||| ||.|||||.||  
vr.LnkklYdakkftdaGfdhk.....DlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacy

PTEN_1 118-183 4.6e-09 31.4 In-house 83-149 (196) alignment
Range on Protein: 118-183
Range on HMM: 83-149/196.0
KIYDGSNDSHTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIA
. || .   .   .|.  ...|||.|. .  |.   |...  ..  |... .|||| ||.||.|| .|
rsydleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 124-270 1.1e-35 117.8 In-house 86-233 (440) alignment
Range on Protein: 124-270
Range on HMM: 86-233/440.0
NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVF
 .|.|| |||  .|||.||| .| |.. . ..|  .    ..||.|||||||.||||  ||.|  | .|||   .||  ..| .|..| .|||| .||.|
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

LHDAVLETVMCGDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLS
.|.|||| ..|||| || ..   ......  .  |  | || .|.  |
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefegys

PTPc_DSPc_SM00012 129-229 2.2e-36 119.6 In-house 2-105 (105) alignment
Range on Protein: 129-229
Range on HMM: 2-105/105.0
LTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK--GPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.|||||||........| ..|.   . |.  .|..|||||||||||||.|.||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle

subfamily_PTPDC1_pd Subfamily PTPDC1 131-225 4e-09 31.2 In-house 84-170 (182) alignment
Range on Protein: 131-225
Range on HMM: 84-170/182.0
QYHLTSWPDHGVPDYATpLMSLHKqVMaTWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkregvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 ..  .|.|.||.   . .. . | |. . . ..| . ||| || ||||  ||  .   .      .. .  .. .|..| | .|| .|  ....
yvynfgwkDygvasler.iLdivk.vv.afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke

subfamily_CDKN3_pd Subfamily CDKN3 133-225 7.4e-06 19.7 In-house 103-190 (202) alignment
Range on Protein: 133-225
Range on HMM: 103-190/202.0
HLTSWPDHGVPDYATPlMSLHKQVMATWSPSKGpILVHCSAGVGRTGTFIAIDIALEqakrEGVVDIAGIVNRLRQQR-MKMVQTLDQYVFLHD
|    .| .||| |.  . . ...  .    ..  ||||  |.||.   ||  . .     . ...    ...||. .  . .||. || .|..
hhypiadglvpdiasc.lkileelrinlkayrk.tlvhcygglgrsslviaclllyl....ddtiepkdaidklrdlkgsraiqtvkqynylse

DSPc Dual specificity phosphatase, catalytic domain 149-183 6.4e-06 21.1 Pfam-A 58-92 (133) alignment
Range on Protein: 149-183
Range on HMM: 58-92/133.0
LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
 ..  ......   ... .|||| ||. |..|.|.
eleeavefiekaeqkgkkvlVHCqaGisRSatlii

DSPc Dual specificity phosphatase, catalytic domain 149-183 6.4e-06 21.1 In-house 58-92 (133) alignment
Range on Protein: 149-183
Range on HMM: 58-92/133.0
LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
 ..  ......   ... .|||| ||. |..|.|.
eleeavefiekaeqkgkkvlVHCqaGisRSatlii

subfamily_eak_pd Subfamily eak 152-233 4.1e-07 23.7 In-house 226-307 (332) alignment
Range on Protein: 152-233
Range on HMM: 226-307/332.0
LHKQVMATwSPSKGPIlVHCSAGVGRTGTFIAIDIA--LEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMC
. |. . |  ||  || . .. |  |.|.|. ||.   | ..|.. .  .  .. . ...|.. | .  |. |....||. .. 
tlkkyiht.ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr

PTPc_motif_SM00404 152-183 2.5e-06 22.4 In-house 68-99 (140) alignment
Range on Protein: 152-183
Range on HMM: 68-99/140.0
LHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
  .... .   ..| .|||| ||| |..|.|.
kvldfienaekkggkvlVHCqaGvSRSatlii

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 155-231 5.2e-19 63.2 In-house 219-295 (297) alignment
Range on Protein: 155-231
Range on HMM: 219-295/297.0
QVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
. . .  | . ..||||||||||.|  .  |. |.. ... . |.| |.. ||.|| ..||||.|. .|.||||. .
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_CG42327_pd Subfamily CG42327 163-226 2.5e-17 57.5 In-house 246-310 (319) alignment
Range on Protein: 163-226
Range on HMM: 246-310/319.0
SKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|.||. |||| ||||||. || |||... .     |||  .|  .|..| . |.| .|| |..  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 165-228 8.4e-18 59.2 In-house 263-341 (350) alignment
Range on Protein: 165-228
Range on HMM: 263-341/350.0
GPILVHCSAGVGRTGTFIAIDIALE------Q-AKRE-------GVV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
 |||||||||||||||....|  |.      .  |.         .   |  |||.||.||..|||.|||..|...|.|
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 165-229 3.8e-13 43.5 In-house 266-342 (349) alignment
Range on Protein: 165-229
Range on HMM: 266-342/349.0
GPILVHCSAGVGRTGTFIAIDIALE---QAKREGV--------V-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 ..||||||| ||||... .|. |.     ..| .           |  ||| ||.||. ||| | |......|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 168-234 4.2e-17 56.3 In-house 2-68 (69) alignment
Range on Protein: 168-234
Range on HMM: 2-68/69.0
LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
.||||.| ||||||||| . . . | | .|||   |. .|. |  ||    .|.|.|||. |..  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 169-234 6.6e-17 55.6 In-house 2-67 (69) alignment
Range on Protein: 169-234
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
||||.| ||||||||| . . . | | .|||   |. .|. |  ||   ..|.|.|||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

0050432 (Phosphotyrosine protein) phosphatases II 232-509 2.8e-72 239.0 In-house 13-290 (308) alignment
Range on Protein: 232-509
Range on HMM: 13-290/308.0
MCGDTEILANEYEMKLQELKE-IDSSTGCSALQSQFDLLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNGYINASYLSGY--REKKAFI
...||.||.. ... ...| . ... .. . |. .|  | .|.| . . .. . ... ||||....|| ..  | |.|...|||||| .||  . ...||
lfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfI

IAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS---ETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSssWDLIQLQVTDWPQ
..|.|..||  |||.|. ...|. ||||. |.|.| | |.||| ..   .....| ..|.| | .....|. |....   .|..|    . ... |.|| 
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges..rtvthfhytnWpd

DGVVREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
.||  .|. .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|. . ..
hgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 234-504 9.4e-67 220.3 In-house 1-276 (298) alignment
Range on Protein: 234-504
Range on HMM: 1-276/298.0
GDTEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTP--DPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKA
|.||| |......||.|.... ... . ....|  |..|.   . .     ....  .||| ..... .   | |..     .  |||||.|..|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDnsSSWDLIQLQVTDWPQD
||..| |...|  |||.|........||||  ||| ..  . .|| |......||  |.| |..|   .| ||..... | .  ..  . ||..| ||. 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdk

GVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
|| .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| 
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

subfamily_PTPN6_pd Subfamily PTPN6 236-508 3e-45 149.5 In-house 2-287 (306) alignment
Range on Protein: 236-508
Range on HMM: 2-287/306.0
TEILANEYEMKLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCDSAK-AHSDKNRSTSYLPRENFLVTLKEN----NGYINASYLSGY--REKKAFI
|..||.| | . .||.. ..|.. . .. .|. |.|          ..||     |||  . || ..  |.|||.    . ||||.|...    ..|..|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyi

IAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET-TNFGEYFVKLDSSKECNGYIERKFHIHSdKDDNSSSWDLIQLQVTDWPQDG
 .|  ...|  |||.|... .   |||.    | |.| |..|| |.|. ...|.. |.  |.|. . || |.....  |...... ...|.. ..||. |
atqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfksWPdhg

VVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLVYTR
| ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | |    .
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

0051299 (Phosphotyrosine protein) phosphatases II 245-509 2.2e-69 229.5 In-house 12-277 (288) alignment
Range on Protein: 245-509
Range on HMM: 12-277/288.0
MKLQELKeidsSTGCSALQSQFDLLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMKNTAR
  ...|.     .| . |. .|. | ...||  .. . . ... .|||....|| ..  | |.     |...||||||..||. |..||..| |..||  
klvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

DFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSD--KDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQ
|||.|. ...|. ||||..|.|.| | |.||| .......|...|.| | .....|. |....      | .. |   .....|.|| .||   |. .|.
dFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

VIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.   |.
flrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 246-504 1.2e-86 285.3 In-house 6-264 (287) alignment
Range on Protein: 246-504
Range on HMM: 6-264/287.0
KLQELKEIDSSTGCSALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKM
|. |. . .  .|    . || .| ||| ..|.|  . |.   ||||.|  |...|. | ||. .. ||||... ||.||||||||.||| ||||.|||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIH
| | .|.|||||| ..|. || |||||...... .||| ..| . .  .||||||.... .. .. .   . | |.|.|.. | | ||.|.| ||.. ..
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkag.dkqqvkqyqitnWdstgkvtepqtillvieemyk

RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | 
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 246-511 1.2e-16 55.0 In-house 13-276 (302) alignment
Range on Protein: 246-511
Range on HMM: 13-276/302.0
KLQELKEIDSsTGCSALQSQFDLLSQVTPDPDDvfCDSAKAHSDKNRSTSYLPRENFLVTLK-ENNGYINASYLSGYREKKAFIIAQSPMKNTA---RDF
. ...| ..|    . ....|. ....  | .   | . |....||.|. .   .. || |. |.. |.||| ..    ..  |.|| | ....    .|
eeeakklvks.ldtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeF

WKMIVDYKVSAIVMLCGLEEDGEeSCYQYWA-DSET-TNFGEYFVKLDSSKECNGYIeRKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVI
|.|. . |.  .|.| | ||  . .  ...   |.. ...|. ||     .. ..    .. |    .. | |       .| |.|. |  .  .. . .
Wrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaelikta

DDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLvyTRYMS
 .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|  . |.|
akv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl..kQyvs

0045450 (Phosphotyrosine protein) phosphatases II 248-509 9.8e-64 211.3 In-house 15-295 (307) alignment
Range on Protein: 248-509
Range on HMM: 15-295/307.0
QELKEIDSSTGCSALQSQFDLLSQVTPD-PDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK------ENNGYINASYL--------SGYREKKAFIIAQS
  |. ..  .. . |. .|  | .||.. ...  . . ... ||||....|| ..  | |.      |...||||||         .||. |..||..|.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKECNGYIERKFHIHSDkDDNSSSWDLIQLQVTDWPQDGVVRE
|...|  |||.|. ...|..||||..|.|.| | |.||| |.. . ..|...|.| | ....||. |.....   | .. |  ..... |.|| .||   
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvpps

PRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLVYTRY
. ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||... . |.
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf

0036941 (Phosphotyrosine protein) phosphatases II 250-509 2.4e-66 219.4 In-house 3-268 (297) alignment
Range on Protein: 250-509
Range on HMM: 3-268/297.0
LKEIDSSTGCSALQSQFDLLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLkENNG--YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVD
|| ...... . |...|. | .. . . .  . . ... .|||....|| ..  | | ...|  ||||||..||. |..||..| |..||  |||.|. .
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

YKVSAIVMLCGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKE--CNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVI
..|. ||||. |.|.| | |.||| .   |. ..|...|.| | ..  ...|. |....     .|. |  . ....|.|| .||   |...|. |. | 
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvr

HRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
...... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.||   |.
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf

0039614 (Phosphotyrosine protein) phosphatases II 250-509 6e-65 215.0 In-house 22-280 (297) alignment
Range on Protein: 250-509
Range on HMM: 22-280/297.0
LKEIDSSTGCSALQSQFDLLSQVTPDpddVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNG------YINASYLSGYRE-KKAFIIAQSPMKNTARDFW
|. ..  .... |. .|  | ...||     .   ... ||||....|| ..  | || ..|      ||||||..||.  ...||..| |...|  |||
llllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

KMIVDYKVSAIVMLCGLEEDGEeSCYQYWADSETtNFGEYFVKLDSSKECNGYIERKFHIHSdkddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDV
.|. ...|..||||. |.|.|   |.||| .... ..|...|.| . ....||. |....      |. |  . ..|.|.|| .||   ....|.... |
rmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellleflelv

IHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|. . |.
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrf

0047943 (Phosphotyrosine protein) phosphatases II 251-509 1e-66 220.5 In-house 3-263 (273) alignment
Range on Protein: 251-509
Range on HMM: 3-263/273.0
KEIDSSTGCSALQSQFDLLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPRENFLVTL-KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYK
. .....| . |. .|.|| ...| . .  . . ... ||||....|| ..  | |  ....||||||..||. |..||..| |..||  |||.|. ...
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VSAIVMLCGLEEDGEESCYQYWADSE---TTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
|. ||||. |.|.| | |.||| ...   ....|...|.| | .....|. |.. . . ....  |   .....|.|| .||   .  .|. |..| . .
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrkal

QKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|. . |.
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 254-505 7.6e-82 269.4 In-house 14-270 (290) alignment
Range on Protein: 254-505
Range on HMM: 14-270/290.0
DSSTGCSALQSQFDLLSQvTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK---E----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIV
. ..| .  ..||  | . .  .  |  . ..  . .||.. ....... .||.   .    .| ||||.|. ||.|||..|..|.|..||..||||.|.
ghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

DYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
. ||..||||.   |.|.. |.|||.||.|...||. .|| . ...|.|||||....... .  ..  ..|.|.| |...| | .| |.|.||  ... |
qekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktq

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLV
 | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .
rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq

0043336 (Phosphotyrosine protein) phosphatases II 254-509 7.2e-64 211.3 In-house 14-268 (278) alignment
Range on Protein: 254-509
Range on HMM: 14-268/278.0
DSSTGCSALQSQFDLLSQVTPdpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDY
   .....|. .|  | ....  |.  .   ... ||||....|| .. .| |.      ...||||||..||. ...||..| |...|  |||.|. ..
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

KVSAIVMLCGLEEDGEESCYQYWAdSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSssWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQk
.|. ||||..|.|.| . |.|||  ......|...|.| . .....|. |.....  .|..|      ... ..|| .||   . ..|. . .|..... 
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsllldflkavreale.

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
  .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|. . |.
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 256-504 3.3e-59 195.5 In-house 19-269 (319) alignment
Range on Protein: 256-504
Range on HMM: 19-269/319.0
STGCSALQSQFDLLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKV
|||   |. .| ||.. ..|  ..   | .  ..||| .  |. ..  |.|.|     .  |||||.. ||.|...|| .|.|..||  |||.|. ....
stgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

SAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIhSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG
| .|||..| | ..  . .|| . . ...|.. |.|.. .| ..|| ||...   | ..  . .. . | |.||...| .. ...|... .. . ..|  
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektq

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . 
sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 256-505 2.2e-49 163.1 In-house 17-266 (288) alignment
Range on Protein: 256-505
Range on HMM: 17-266/288.0
STGCSALQSQFDLLSQVTPDPDDVFCDSAKaHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKV
 .. . ...... |...  . ..     |.   .|||    || .   | ||.     .. ||||||. |...||..| .|.|. .|  |||... ..|.
arnrtgfseeynsLaalektksvtagrlav.nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

SAIVMLCGLEEDGEESCYQYWADSET-TNFGEYFVKLDSSKECNGYIERKFHIHsdkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI
| |||| .| |.|.. | .|| |... .|.|.  |.| .||| . ...||. ..     . .  .. |.| . ||..|| .  . .|.... |   .|. 
stivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

gGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLV
  ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | || 
.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk

subfamily_PTPN23_pd Subfamily PTPN23 256-497 5.1e-46 151.8 In-house 11-259 (288) alignment
Range on Protein: 256-497
Range on HMM: 11-259/288.0
STGCSALQSQFDLLSQVT-PDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLSGYREK-KAFIIAQSPMKNTARDFWKMIVDYKVSA
  | .||. .| .| |    .  .  .  || .|.||||.  || ..  |.|.. .. |||||.. .       ||..|.|...|. |||.|... |.| 
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCGLEEDGEESCYQYWAD--SETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIH---RQQ
||||   || |.... .||     ||..||.. | | | .| . ..||.....  . |.    ..  ||.| ||. ||   | |.||..| | .    .|
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldada..vksvshlqltsWpelGvPasPetllqfldevesayeavq

KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSK
.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqR

subfamily_PTPN9_pd Subfamily PTPN9 256-496 1.8e-41 137.1 In-house 12-268 (297) alignment
Range on Protein: 256-496
Range on HMM: 12-268/297.0
STGCSALQSQFDLLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKV
..| . |. ..  . . ..    . .   .| . ||| |  |  ..  |.|.. .      ||||... ||..||||| .| |.|.| .|||.|. . .|
ekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

SAIVMLCGLEEDGEESCYQYWA--DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSssWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-
  |||   ..| |   | |||   . ....||.. |.  . .| . | .|...|.  |...|    ..  |.. ||  || ..  ..|.|.. | ..|  
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees..rkvthfqflsWPdyGvPssaaslldvlekvrekqal

-----------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRS
           .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 257-507 7.2e-113 371.2 In-house 12-283 (301) alignment
Range on Protein: 257-507
Range on HMM: 12-283/301.0
TGCSALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVS
.    ...|.. |....... .| ....... .......... ...... |.|     . ||||||..||.|||.||.||.|||.| .|||..|...|..
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKEC-------------------NGYIERKFHIHSDKddnsSSWDLIQLQVTDWPQDGVVREP
.|||...|.|. ...|.||| .||...  .....   ..|.                   ||||||||...|||    ||||..||||||||||||||||
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk....sswdvlqlqvtdWpqdGvvrep

RTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL-VYT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  ||
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyt

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 257-504 2.6e-92 304.2 In-house 19-269 (305) alignment
Range on Protein: 257-504
Range on HMM: 19-269/305.0
TGCSALQSQFDLLSQVtPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNG---YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAI
. ...|. |...| .  ... || ...|.......... .|. . . .| ||...   ||||||. ||..||..|.||.|.||| .|||..||..||| |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCGLEEDGEESCYQYWADSETT--NFGEYFVKLDSSKECNGYIERKFHIHSDKDdNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG
|||..| |.|.. |.|||..|.|   .|||. |.| |.|. ..|||||..|  ... .. |  ..|.|.||||..||.... ..|..|..| ..|.|  |
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 257-503 4.2e-26 86.7 In-house 13-262 (307) alignment
Range on Protein: 257-503
Range on HMM: 13-262/307.0
TGCSALQSQFDLLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE---NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAI
 | .||. .|  |.. ||.   |  .. .| .|||| .    ...  . .|       || | ||    . | || || |..||  .|| |... || ..
kgvqalvdefrvlakktpe..gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLCGLEEDGEESCYQYWADSE--TTNFGEYFVKLDSSKECNGYI---ERKFHIHSDK-DDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ
.||| . | ..  | |||   |  .  |||    .  ..   . .   |    . . | |  . |  . .|| ..||. || .   | . ... |   . 
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn

kigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTT
     |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |
.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 259-402 1.5e-18 61.6 In-house 19-178 (350) alignment
Range on Protein: 259-402
Range on HMM: 19-178/350.0
CSALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK-------------ENNGYINASYLSGY----REKKAF--IIAQSPMKNTAR
 |  .|.. | |. . . .||   .      ||| .  || |   | ||             . | ||||.||.      . .  |  | .|.|...|  
nstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvd

DFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSettNFGEYFVKLDSSKECNGYIERKFHI
||.|.|.  ||  |..|  . | . | ||.|| .    .. .. ||| | .|  . |.     
dfykvillnkvkvilsltsdvelnlekcyrYWqeg...sydditvklaskwenimgindssly

0040438 (Phosphotyrosine protein) phosphatases II 260-509 2.6e-65 216.1 In-house 18-267 (317) alignment
Range on Protein: 260-509
Range on HMM: 18-267/317.0
SALQSQFDLLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIV
 ||...|  | ....|  .  . . ... ||||....|| ..  | |.      ...|||||| .|...|..||..|.|..||  |||.|. ...|. ||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGP
||. |||.| | |.||| . ||...|...|.| | .|..|.. |....  .  ..| |  . ... |.|| .||   |...|. .. | . ..  . |||
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
|.||||. |.|.|... . . |||.. || |||... | .|. .||||.|. . |.
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrf

subfamily_PTPRG_pd Subfamily PTPRG 260-503 1.1e-51 170.8 In-house 19-272 (563) alignment
Range on Protein: 260-503
Range on HMM: 19-272/563.0
SALQSQFD-LLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNG------YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSA
  .. .|. | |.....  |.   ...    ||| .. .. ..  |.|..  |      ||||.|. ||. .||||..| |.|.|. |||.|| . .|. 
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHS----DKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQK
|||.  |.|.| . | .||   |. ..|.  |.| ...    | .|.. |.     .|..  .    .| . |.||. ||   .  ||. .     . .|
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saank

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.|
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

subfamily_PTPRB_pd Subfamily PTPRB 260-503 1e-48 160.9 In-house 25-270 (293) alignment
Range on Protein: 260-503
Range on HMM: 25-270/293.0
SALQSQFDLLSQVTPDPDdVFCDSAKAHSDKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIV
  .. ... |..|  |   | ...... ..||| |  || ..  | |     .... ||||.|..||. .. || .| |. .|  |||.|. . |.|.||
lrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv

MLCGLEEDGEESCYQYWADS-ETTNFGEYFVKLDSSKECNGYIERKFHIHSdkddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGG
||  | | | . | .|| .  |....|.  |.| ...| . .. |...|.     .... .. |.. | ||. ||  ...|.|. .  | ... ..   .
mltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | |
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt

subfamily_PTPN3_pd Subfamily PTPN3 260-503 2.7e-42 139.6 In-house 15-260 (280) alignment
Range on Protein: 260-503
Range on HMM: 15-260/280.0
SALQSQFDLLSQVTPDPDDVFCDSAkAHSDKNRSTSYLPRENFLVTLKENN-GYINASYLS----GYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIV
 |.  ||. | .  |. .   .  . .  .|||    || ..  |.|||..  ||||.|..    .    . .|..| |...|| |||.|. . |.| ||
Gavlaqfeqlyrkkpglaisaarkp.enlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLCGLEEDGEESCYQYWADS-ETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDnsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGP
||  | |.|   |.||| .. .....||. ||. ...| . |. |.. ..  . .   .  ..||| ..||. ||  ..  .|.... | .....    |
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk..eerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeeP

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
||||||  . |.||.  . . |    |.  | . .. . .|  .   | |
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 261-504 1.1e-35 118.0 In-house 7-245 (267) alignment
Range on Protein: 261-504
Range on HMM: 7-245/267.0
ALQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGL
 .. .|.|. .....   . .  |.   ..||    || ..  | |.. .. ||||||. ||. |.|||. | |.|||  ||...| |.||. ||.|   
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

eedGEESCYQYWADS--ETTNFGEYFVKLDSSKECNGYIERKFHIhsdKDDNSSSWDLIQLQVTDWPQDGvvrEPRTVLQVIDDV-IHRQQKIGGGPVVV
   ...   ..|     .. .. .  |.    || | |    . .   |  | |. ..       |  .    . .  |. .  .  . | . |. |.||
...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvv

HCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk

0046845 (Phosphotyrosine protein) phosphatases II 262-509 2.2e-66 219.5 In-house 2-265 (284) alignment
Range on Protein: 262-509
Range on HMM: 2-265/284.0
LQSQFDLLSQVTPDPD-DVFCDSAKAHSDKNRSTSYLPRENFLVTLK------ENNGYINASYLSGY-----REKKAFIIAQSPMKNTARDFWKMIVDYK
|. .|  | ..|...  .. .  .... .|||....|| ..  | ||      |...||||||..||     . ||.||..| |..||  |||.|. ...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKECNGYIERKFHIHSDkDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK
|. ||||..|.|.| | |.||| ... . ..|...|.| | .....|. |.. .    . .. |  ......|.|| .||  .|. .|. ...| . ...
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLVYTRY
  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.||   |.
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf

DSPc_SM00195 262-504 4.5e-63 208.4 In-house 2-248 (263) alignment
Range on Protein: 262-504
Range on HMM: 2-248/263.0
LQSQFDLLSQVTPDPdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVML
|. .|. | . |..  .. .   |. ..|||.. .|| ..  | ||..     . ||||.|..|...||..|..| |...| .|||.|... ||. ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKECN-GYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGP
.  ||.|.| |..|| ..  ....||.. ||| . ....  .| |....  ...  . . .. |.|...||. ||  ... ||...  | ......  ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.||
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 262-504 4.5e-63 208.4 In-house 2-248 (263) alignment
Range on Protein: 262-504
Range on HMM: 2-248/263.0
LQSQFDLLSQVTPDPdDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVML
|. .|. | . |..  .. .   |. ..|||.. .|| ..  | ||..     . ||||.|..|...||..|..| |...| .|||.|... ||. ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKECN-GYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGP
.  ||.|.| |..|| ..  ....||.. ||| . ....  .| |....  ...  . . .. |.|...||. ||  ... ||...  | ......  ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.||
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 262-504 5.9e-56 184.4 In-house 8-252 (283) alignment
Range on Protein: 262-504
Range on HMM: 8-252/283.0
LQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-NNGYINASYLS---GYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLC
 . ... | ...  . |. ..||. .  |||    .| ... | ||  .. ||||...     |...| .||||||...| .|||||. | |..||||| 
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

GLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWdLIQLQVTDWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPV
 | || .. | |||    . ..||. | |      | .| ... .. .   .|.   |   || ||    .  .. ...     .. ||  |..   ||.
klqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidW....leygeqaiinslvkfnkvislqteskkgPi

VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 262-504 4.8e-37 122.4 In-house 22-265 (439) alignment
Range on Protein: 262-504
Range on HMM: 22-265/439.0
LQSQFDLLSQVTPDPDDVFCDSAKAHSD-KNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVM
..  |. .. . ||   . .  |. ... |||  .  . .   |||.|  |     |||| |. || ..| .| .| | |.|. |||..... |.. |||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LCGLEEdgeesCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVV
|. | |      |.||  .. . .|.  |. |   |   |. | |..  ..| .     ..|.. . ||.  |  .   ||. .  .   ..|   ||||
ltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvv

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .|
vhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal

subfamily_PTPRN_pd Subfamily PTPRN 262-503 3e-31 103.2 In-house 31-277 (297) alignment
Range on Protein: 262-503
Range on HMM: 31-277/297.0
LQSQFDLLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVM
|. ... | .   .|      .|.   .||||.. || ..  |.|||.     . ||||| .      . |.| .|.|. .|  |||.|. .  |  ||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSK-ECNGYIERKFHIHSDKddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIhRQQKIGGGPV
|. |||.| . |..|| |  .  .. | |.| | .  |. |. | |..   .  .| .  . |.    ||. ||  .....|.    |  .  .    |.
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq..tsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpi

VVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTT
|||||| . |.|||. . . |..  |    .|.    . .|  .|| | |
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt

subfamily_CG7180_pd Subfamily CG7180 263-503 6.5e-44 144.7 In-house 16-275 (296) alignment
Range on Protein: 263-503
Range on HMM: 16-275/296.0
QSQFDLLSQVTPD--PDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVM
. ...|. ..||    .|  ..  |   .|||    .| ... | |..     .. ||||.|  ..  ||..|. . |.|.|  .||... | ..||.|.
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LCGLEEDGEeSCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSD--------KDDNSSSWDLIQLQVTDWPQ-DGVVREPRTVLQVIDDVIHRQ
|.   .  .  . .||     ...|| ||.. ..|.      |.|..           |. .     . ..|.| |.  | |     ......  |   .
Ltktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

QKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | .
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

subfamily_ptpA1_pd Subfamily ptpA1 264-475 4.3e-20 66.8 In-house 25-253 (418) alignment
Range on Protein: 264-475
Range on HMM: 25-253/418.0
SQFDLLSQVTpDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREkKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCG
 .| || .    | .      |  . ||| |  || .   | ||     | . |||| |. |    | || .| |. ||  |||.|. . ..  ||||  
eefrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsr

LEEDGEESCYQYWADSET-----------TNFGEYFVKLDSSK-EC-NGYIERKFHIHSdkddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHR
  |.    | .|| .                || | |.|     .     | |. ..      .  . |. | |   ||.  .    . . |..  .  |
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf....egetrditqyqyegwpdhnipdhtqpfrqllhsitnr

QQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
|..|        |..||||  | |.| .|.  | .
qnqiipssdrnvpiivhcsagvgrtgtfctavimm

subfamily_PTPN13_pd Subfamily PTPN13 266-503 7.3e-37 122.1 In-house 17-254 (273) alignment
Range on Protein: 266-503
Range on HMM: 17-254/273.0
FDLLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKENNGYINASYLSGYR--EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDG
|. | .. |  |..     |.. ||||    || ..  |.|... ||||||..      ..  .|..| |. .|..|||.|. . |.. |.|.    |.|
fkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekg

EESCYQYWADSETTNF---GEYFVKLDSSKECNGYIERKFHIHSDKddNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSD
.  | .|| .|.  .    . . |.|   .. .|.  |.....  .   . | .. .|. ..||  || ...  .||..  | . |.    ||.||||| 
kvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsa

TVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
 . |||.. .. . |.  . .  .|| .. . .|. . | | |
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt

subfamily_PTPN1_pd Subfamily PTPN1 270-504 3.7e-31 102.9 In-house 13-257 (290) alignment
Range on Protein: 270-504
Range on HMM: 13-257/290.0
SQVTPDPDDVFCDSAKAHSDK--NRSTSYLPRENFLVTLK-ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEES
 ... . .|. . .|| ....  ||     | .   ..|. ..| ||||| .   . |. .|..| |. ||.  ||.|. . |  |.|||  . | ..  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CYQYWADSE---TTNFG--EYFVKLDSSKECNGYIERKFHIHSDKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSD
|.|||   |   .  .   .. ||| | .. . |. |.....  | ..  . ....   | ||  || . | . |. . .| .    .   ||.|.||| 
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

TVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTL
 . ||| .| |   | . ....    ||. .|  ..|. . | . | 
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

0045098 (Phosphotyrosine protein) phosphatases II 271-510 1.3e-57 190.6 In-house 17-264 (278) alignment
Range on Protein: 271-510
Range on HMM: 17-264/278.0
QVTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTlkennGYINASYLSGYreKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQY
 ....|.....     . |||| ...|| ..  |      .||||||..||  .|.||..| |...|. |||.|. ......||||..|.|.| | |.||
lllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WADSETTNFGEYFVKLDSSKECNGYIERKFHIHSD--KDDNSSSWDLIQLQVTDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPV
| .... ..|...|.| | .... |. |.....    .. .  |. . .|. . ||  ||  .|  . .|.... . .....             .||||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLVYTRYM
.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..|   |..
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 272-429 1.2e-18 61.7 In-house 81-236 (244) alignment
Range on Protein: 272-429
Range on HMM: 81-236/244.0
VTPDPDDVFCDSAKAHSDKNRSTSYLPRENFLVTLKE---NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEescy
. |||  .        | |||  . || .   | | .    | |||||..        .|..| |. .|. |||||... .|  .|.|  .||. |    
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....

qYWADSETTNFGEY--FVKLDSSKECNGYIERKFHIHSDKddNSSSWDLIQLQVTDWPQDGVV
 || |||  .. |    | |    |       .. | ||   | |   |  .|...|| ||  
.ywpdseplewyeeditvtltdrdefknikasnleiesdm..neshqaltmfqisnwpsdgtt

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 274-503 9.8e-46 151.0 In-house 29-262 (315) alignment
Range on Protein: 274-503
Range on HMM: 29-262/315.0
PDPDDVFCDSAKA--HSDKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEES
||||     .|.      |||    || ..  | |     . .. ||||||. .. . ||.| .| | | .  |||.|....||..|||.  ..|.   .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CYQYWAD--SETTNFGEYFVKLDSSKECNGYIERKFhIHSdKDDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSR
| ||| |  .....||.. |.| | . . . . ||. .   | ..  |  . | | |.||. || ..  ..|..| .|    ..    ...||||  | |
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtr.ksee..srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGr

SGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.|| .|.   ..| | . .||||.. | .|. .|  | |
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 274-503 6e-29 95.6 In-house 30-221 (392) alignment
Range on Protein: 274-503
Range on HMM: 30-221/392.0
PDPDDVFCDSAK--AHSDKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGees
|.||     .|.      |||    || ..  | |       .. |.||||. ..  .||.| .|.|   .  |||.|. . .|..|.|.  |.|     
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

cyqywadsettnfgeyfvkldsskecngyierkfhihsdKDDNSSSwdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSG
                                       | |.  .    | ..|.||...| .   ..|..| .|     .    |...|||  | |.|
.......................................kgddart..vaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtg

VYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
|  |.   . ..|   .||||..   .|| .|  | |
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqt

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 277-502 1.4e-22 74.9 In-house 40-265 (301) alignment
Range on Protein: 277-502
Range on HMM: 40-265/301.0
DDVFCDSAKAHSDKNRSTSYL--PRENFLVTLKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD-
|..    |  . ||.|  .    |     |  . .   | | ...   . . ||..|.|.|||. ||| |.| |.|  ||||.   |. || | .| .  
dhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

-SETTNFGEYFVKLDSSKEC--NGYIERKFHIHsDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCS
 ||. . | . .|. ...    .  ..|..... |  .. ..  ..  | ..|.. || .    . .... .. . .|    |.|||||. . ||  . .
isekldigrfkikiknkelilnkkiskrtleve.dstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafig

VSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
  .   . .|.  ... .  | .|  .  .| 
teylareveadptieltealkhlrehrwngvq

0040439 (Phosphotyrosine protein) phosphatases II 278-509 4.7e-60 198.6 In-house 2-237 (249) alignment
Range on Protein: 278-509
Range on HMM: 2-237/249.0
DVFCDSAKAHSDKNRSTSYLPRENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA
.. . . ... ||||....|| ..  | |.       ..||||||..||. |..||..| |...|  |||.|. ......||||. |.| | | |.||| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
.......|...|.| | .....|. |.....     ...|    ..|.|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...  
lggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 . ||| . |. ||.... | .|. .||||... . |.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 279-504 8.6e-19 62.5 In-house 24-281 (297) alignment
Range on Protein: 279-504
Range on HMM: 24-281/297.0
VFCDSAKAHS-DKNRSTSYLPRENFLVTLKE---NNGYINASYLSGYREKK--AFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA
 |  . .  |  ||| .  |  ..  | |.    .. |||| |.    |..   .|.|| |...|  |||.....  | .|||.. |.||| . |. || 
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DS--ETTNFGEYFVKLDSSKECNgYIERKFhIHSDKDDNSSSWDLIQLQVTDWPQDGVVR----EPR-------------TVLQVID---DVI------H
..  |  . |.. |.  ||   . .   ..         | |  .   |   ||. ||        |              .| ...    ..       
svvqerlkagdvvveflsstsde.fdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
| ..    ...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl

subfamily_PTPN14_pd Subfamily PTPN14 280-506 9.2e-35 115.1 In-house 42-284 (300) alignment
Range on Protein: 280-506
Range on HMM: 42-284/300.0
FCDSAKAHSDKNRSTSYLPRENFLVTLK----ENNGYINASYLSGY--REKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD
 . . .   .|||    || |.  | |.    ...|||||| ..     ... .|.||.|...| .|||.|. . .|. ||||   |||| | ...|. .
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

S----ETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDT
.    .| .||.. |    |.. . .| ......      .   ... || ||||..|| ..... |. ...|    .  ....       ||.||||. 
leskkktvefgkfkvttkfsedsdsvittglklkhlps..keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

VSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVY
| |.||   . . ..  . . ..|. .| . .|. .   | ||  
vGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaq

0037934 (Phosphotyrosine protein) phosphatases II 282-509 1.1e-50 167.9 In-house 5-233 (243) alignment
Range on Protein: 282-509
Range on HMM: 5-233/243.0
DSAKAHSDKNRSTSYLPRENFLVTLkENNGYINASYLSGYreKKaFIIAQSPMKNTARD----FWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAdsE-T
 . ... .||| ...|| ..  | | |...||||..  ..  .. .|. | |...|  |    ||.|. ......||||. |.| | | |.|||   . .
allpenlsknrysdilpydhsrvkl.egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev

tNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSsWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYC
 ..|...|.| |......|. |....   . |. . .  |... . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...
.tygdftvtllseehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

SVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLVYTRY
   . |...   | ||.... | .|. .|| ||.|. . |.
aaylmllll...g.vdleeavkllreqRpgkavqtpsqyrf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 282-502 2.4e-19 64.0 In-house 47-274 (310) alignment
Range on Protein: 282-502
Range on HMM: 47-274/310.0
DSAKAHSDKNRSTSYLPRENFLVTLKE----NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT
.. | .  ||| .  . ...  | ||      . || | |.     ...|| .| |.. |  |||.|| . .  .|..||   |.|   |  ||     |
eaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

-NFGEYFVK-L-DSSKE---CNG---YIERKFHIHsDKDDNSSSWDLIQLQVTDWPQDGVVREprtVLQVIDDVIHRQqkIGGGPVVVHCSDTVSRSGVY
  .|   |  | .||.|   ||    ..  .  .  ..  |     .  ..  .||. ||  |     . . . .  |  .  ||.|||||  . | .| 
etygcirvtnlsesseefeicnlavtfvpdnvpvd.eqpanlkelrvslikwpnwpdrgvpde...kchtvpqrllaq..vrhgpcvvhcsagkdrlyvv

CSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
... . ... .    ||. .|   ...|.   . 
valklkidkldrglkvdaeevktellksraiciq

0042113 (Phosphotyrosine protein) phosphatases II 283-509 2.4e-57 189.5 In-house 5-234 (245) alignment
Range on Protein: 283-509
Range on HMM: 5-234/245.0
SAKAHSDKNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT
. ... ||||....|| .. .| |.. .|     |||||| .||| .. ||..| |...|  |||.|. ......||||. .||.| . |.||| ..|..
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

NFGEYFVKLDSSKECNGYIERKFHIHSDkdDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
..|...|.| | . ...|. |..... .   .. |   |... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . |||
tygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

CKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
 ..|. |..... | .|. .||||.|. . |.
lekelgvsleeavkelrsqRpgavqtpsqyrf

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 283-507 4e-46 152.8 In-house 57-280 (319) alignment
Range on Protein: 283-507
Range on HMM: 57-280/319.0
SAKAHSDKNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCgleedgEESCYQYWADSETT
  .   |||| .  |. ..  | |.  .|     |||||...||. |. .| || |..||  |||.|| .|..|.||.|       .. | |||      
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

NFGEYFVKLDSSKECNGYIERKFHIHSDkDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLE
. ... ||.|| .|.. |. |....  |   .    .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.
keerfkvkvdsveetaeyvvrdielsed.gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

QCKAEGVVDVFQVTKAVRRSKPGAVTTLVYT
. | |  |||... . .|. ..  |  ||  
rmkeekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 283-503 9.8e-44 144.8 In-house 44-273 (325) alignment
Range on Protein: 283-503
Range on HMM: 44-273/325.0
SAKAHSDKNRSTSYLPREN---FLVTLKEN--NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEdGEESCYQYWADS--E
   .  .|||    .. ..    |.|.|..    |||||||  ...|. |. ||.|. .|  |.|....|.. | .|.|  |.. |...| .|| .   .
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl.gkdrcavywpkemgk

TTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSwdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCS
. .||   ||| . .|   |. |....   |. .. |  . |.|.  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |
sktfGglevklrtieeisdyvhrvldvkqvkkGetrs..vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

VSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.   |..   |  ||.|.. | .|. .|  | |
lysalakvieesrvdifgfvkklrkdrpsmvet

0049772 (Phosphotyrosine protein) phosphatases II 283-504 7.5e-23 77.2 In-house 42-266 (314) alignment
Range on Protein: 283-504
Range on HMM: 42-266/314.0
SAKAHSDKNRSTSYLPREnFLVTLK----ENNGYINASYLSGYrekKAFIIAQSPMKNTARDF----------WKMIV--DYKVSAIVM-----------
.  .. ||||..  || .  .| |.    .. .||||||..|.   ..||..| |...|  ||          |.|..  |..|  |||           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCGLEEDGeescyQYWADSETTNFGeyfvkldsskecngyierkfHIHSDKDDNssSWDLIQLQVTDWPQdGVVREPRTVLQVIdDVIHR
          |..| . |      ..  ..  ..                      .. |...   .   |..  ...|  | .  .. ..... ..|..
rLdaAlgKtpllildgng.....neptaadlellk....................eelydpelf..erlgikylripvpD.gsaplledfdefl.efiee

QqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTL
     ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|
a..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieql

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 283-480 3.1e-20 67.0 In-house 51-250 (305) alignment
Range on Protein: 283-480
Range on HMM: 51-250/305.0
SAKAHSDKNRSTSYLPRENFLVTLKE--NNGYINASYLSG-YREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETT
||.    ||| .    ... .| |..     || | |.      .| || || |. .|  .|| |... ||  |||||   | |   | |||     |  
sadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

NF--GEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGL
..  |    ..  ||  .   | .  .       . .  . .|| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   |
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyil

EQCKA
|.   
ekiae

subfamily_PTPN12_pd Subfamily PTPN12 284-503 2.5e-42 139.7 In-house 37-262 (290) alignment
Range on Protein: 284-503
Range on HMM: 37-262/290.0
AKAHSDKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS--ET
.. .  |||    || ..  |.|.     |...||||... |  .|...| ||.|. .|  |||.|| ...|. .||.| . | |   | .||...  |.
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

TNFGEYFVKLDSSKECN-GYIERKFHIHSDkddnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGL
..|||. |.|.. | .. ... | .... .    . |  . |.. |.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  
lefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

EQCKAEGV---VDVFQVTKAVRRSKPGAVTT
|. ||| .   .|||..   .|. .. .| |
ellkaekipeeldvfdlvlelrkqraalvqt

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 284-496 1e-21 72.1 In-house 32-248 (285) alignment
Range on Protein: 284-496
Range on HMM: 32-248/285.0
AKAHSDKNRSTSYLPRENFLVTLKEN-NGYINASYLS-GYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETTNF
 .|  | || .     |.  | ||.    || ||..    ... ..| .| |. .|  |||.|| . |.. ..||| | | | | |  |. .   |  .|
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GEYFVKLDSSKE--CNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQ
|.| . |   ||    | |   . .   .| .|    . ..||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatir

CKAEGVVDVFQVTKAVRRS
   .  ...... . .|  
imenpniemldivremram

subfamily_PTPRA_pd Subfamily PTPRA 285-505 4.8e-55 181.7 In-house 56-282 (330) alignment
Range on Protein: 285-505
Range on HMM: 56-282/330.0
KAHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNF
.   .|||    || .   | | .        |||||.. ||.||. || || | ..|  |||.|| ..| ..||||  |.|  || |.||| |  .  .
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty

GEYFVKLDSSKECNGYIERKFHIH--SDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQ
|.  |... ..... |  ||| ..  .|. .. .|  . |.  | ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||.
GnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavler

CKAEGVVDVFQVTKAVRRSKPGAVTTLV
 |||..||||.. | .|  .|  | |. 
vkaerkvdvfefvkrlrlqrpqmvqtde

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 286-505 2e-58 192.5 In-house 8-229 (250) alignment
Range on Protein: 286-505
Range on HMM: 8-229/250.0
AHSDKNRSTSYLPRENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEEsCYQYWADSETTNFG
.  .||| . ... ..  | |....      |||||.| ||.|.||||..|.|...|  |||.|....|...||||  |.| ... . |||   .....|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

EYFVKLDSSKECNGYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  |.| |..|   |. ||. . . |   ...  . ||. . ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | 
dvtvsllskeefadytkrklklskakk..aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVVDVFQVTKAVRRSKPGAVTTLV
| |||||.| |..|. .|.||..| 
ekvvdvfkvikvlrkdrphavesle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 286-503 2.2e-57 189.5 In-house 45-265 (318) alignment
Range on Protein: 286-503
Range on HMM: 45-265/318.0
AHSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFG
.   ||| .  |. ..  | |..        ||||.|. |||.|||.| ||.|. .| .|||.|. . . . ||||  .|| | . . .|| .......|
vnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg

EYFVKLDSSKECNGYIERKFHIHSdkDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  |.|....|.. |. |.|...   .....| .  | ..|.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. ||
klvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerika

EGVVDVFQVTKAVRRSKPGAVTT
|..|||||. | .|. ..  | |
ealvDvfqtvkqlreqrnlmvqt

subfamily_PTPRK_pd Subfamily PTPRK 286-503 2.9e-50 165.9 In-house 42-262 (314) alignment
Range on Protein: 286-503
Range on HMM: 42-262/314.0
AHSDKNRSTSYLPRENFLVTLK---E--NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTnFG
 . .||||.  |. .. .|.|.   .  .. ||||... .|.  .|||..| |...| .|||... |.. ..||||  | | |   |..|| .  .. .|
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

EYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  |.| ...  . .. | | ..  .   .    . |.| . ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . 
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier

EGVVDVFQVTKAVRRSKPGAVTT
|||||||.. |..| .|.  | |
egvvdvfnavktlrsrkvnmvet

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 286-507 9.8e-46 151.5 In-house 24-244 (284) alignment
Range on Protein: 286-507
Range on HMM: 24-244/284.0
AHSDKNRSTSYLPRENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCgleedgEESCYQYWADSETTNFG
   |||| .  |. ..  | |.   |     |||||...||. |. .| .| |..||  |||.|| .|..|.||.|       .. | |||      . .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

EYFVKLDSSKECNGYIERKFHIhSDKDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCK
.. ||.|| .|.. |. |.... |..  .    .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. |
rfkvkvdsveeseeyvvrdiel.sedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

AEGVVDVFQVTKAVRRSKPGAVTTLVYT
 |  |||... . .|. ..  |  ||  
eekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 286-503 6.8e-45 148.3 In-house 27-253 (274) alignment
Range on Protein: 286-503
Range on HMM: 27-253/274.0
AHSDKNRSTSYLPRENFLVTLK------ENNGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT-
 .. ||| .. || ||  |.|.      |.  |||| |. ||.| .||.. .| |. ||  |||.||   .|. ||||  |.|  |. | .|. |.| . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---NFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSsswdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVS
   ..|.  .| .. .|.|.|  ||. ... .. .|    ..    ||||   . ....|.|.....| . ...     .|||||||  . | |.. ..|
iserygdveikvekiverndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

IGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
|.. | ..|.||||....  .|  . | | |
iavrqlreeivvdvlkivcnlrldrGGmvqt

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 286-510 3.5e-34 112.9 In-house 37-269 (287) alignment
Range on Protein: 286-510
Range on HMM: 37-269/287.0
AHSDKNRSTSYLPRENF--LVTLKENNG--YINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET-TNFG
|   ||| .  || ..   |.. . . |  |||| |...|....||| ||.|.  | ||||..... ........    |..   ||.|| . |     |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFV-KLDSSKECNGYIERKFHIHsDKDDNSSsWDLIQLQVTDWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGL
 | |  || ..    |  | . .  | . . .   . ||.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . .
GysvvlldydikePeygvralrli.dletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRYM
.. .  | ||| .|   .|  . . | . |  |..
srledlGrvdvaavvirlreyraalvqavvqlrll

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 287-503 5.2e-50 165.2 In-house 51-269 (297) alignment
Range on Protein: 287-503
Range on HMM: 51-269/297.0
HSDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYREkkAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEeSCYQYWADSETTNFGE
  .|.| .  || .   |.|.         |.|||.. |...   .|  | |||.|  |||.|..|..||.||||  ..|  . .| .||.|. .|.||.
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGd

YFVKLDSSKECNGYIERKFHIHSDKDdnSSSWDLIQLQVTDWPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK
  |.| | .|..|.|.|....  .|    .   . | | ..||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . |
vsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

AEGVVDVFQVTKAVRRSKPGAVTT
 |  ||.|.. | .|...|  | |
rekevdifglvkklrqerpylvqt

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 287-439 2.4e-10 34.5 In-house 47-199 (303) alignment
Range on Protein: 287-439
Range on HMM: 47-199/303.0
HSDKNRSTSYLPRENFLVTLKEnNGYINASYLSGYREKKAfIIAQSPMKNTARDFWKMIVDYKVSAIVMLCG-LEEDGEESCYQYWADSETTNFGEYFVK
  |||| .  .  .   | | .   || ||||    .||| |..| |.  || |||.||.. ||  ...|    | |     . .  . .  .| | ...
nmdknrfvdvicldhskvklsd.ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersir

LDSSKECNGYIERKFHIHSDKDDNSSSWDLIQlQVTDWPQDGVVRE--PRTVLQVI
.   |. .     .... |  . .  |.  .. .  .||.. .  .  |. | |. 
vgefkrvelgdgwvlkvlsvsngdyksflhvh.hykawphnsipsdgspkfvkqiw

Y_phosphatase Protein-tyrosine phosphatase 288-506 1.5e-62 206.5 Pfam-A 2-223 (235) alignment
Range on Protein: 288-506
Range on HMM: 2-223/235.0
SDKNRSTSYLPRENFLVTL---KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEY
..|||....|| ..  | |   .... ||||.|..||.|||.||..| |.|.|  |||.|....||..||||. ||| |.| | |||   ..|....|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

FVKLD-SSK-ECNGYIERKFHIHSDKDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.|.|  ..| ....|. ||......|...  .  . ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..|
kvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVVDVFQVTKAVRRSKPGAVTTlvY
|. |||.|. | .|...||.|..  .
eeevdvlqivkelRkqRpgmvqs..l

Y_phosphatase Protein-tyrosine phosphatase 288-506 1.5e-62 206.5 In-house 2-223 (235) alignment
Range on Protein: 288-506
Range on HMM: 2-223/235.0
SDKNRSTSYLPRENFLVTL---KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEY
..|||....|| ..  | |   .... ||||.|..||.|||.||..| |.|.|  |||.|....||..||||. ||| |.| | |||   ..|....|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

FVKLD-SSK-ECNGYIERKFHIHSDKDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.|.|  ..| ....|. ||......|...  .  . ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..|
kvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVVDVFQVTKAVRRSKPGAVTTlvY
|. |||.|. | .|...||.|..  .
eeevdvlqivkelRkqRpgmvqs..l

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 288-510 9.9e-41 134.5 In-house 21-256 (270) alignment
Range on Protein: 288-510
Range on HMM: 21-256/270.0
SDKNRSTSYLPRENFLVTLKEN-----NGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT----
.  ||..  ||  .  |.|.|        |||| |. |. . ||..| |..|...| ..||.||.. ||.||||. ||||.| . | .||. .  .    
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

NFGEYFVKLDSSKECNGYIERKFHIHsdkdDNSSSWDLIQLQVTDWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCS
..|.  |   |..  .||| .. ...    .....  |.  . ..||..||.||.        .|... .|  .....  ..|..||||. | |.|.   
edgkikvlalseekeegyiltrlrle....ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

VSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVYTRYM
. |...  . .. ||| .. ...|. ..  | . .  ...
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl

subfamily_Ptp69D_pd Subfamily Ptp69D 289-504 7.1e-54 178.0 In-house 50-272 (307) alignment
Range on Protein: 289-504
Range on HMM: 50-272/307.0
DKNRSTSYLPRENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYF
 |||.    . ..  | ||     |.  |||||.. ||.||| ||.|| |. .|. |||.|| . .|  ||||  |.|  .. | .||.. .....|.  
lknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdil

VKLDSSKECNGYIERKFHIHSDK---DDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
||| |..... ||.|....   |    .   |  ..| . | |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.||
vklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlka

EGVVDVFQVTKAVRRSKPGAVTTL
|  ||.|...| .|. ..  |. |
edkvdifetvkdLrsqRnllvqsl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 289-503 3e-44 146.0 In-house 45-261 (515) alignment
Range on Protein: 289-503
Range on HMM: 45-261/515.0
DKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETTNFGE
 |||    || ..  | |     . .. |.||||. ..   ||.| .| | | .  |||.......|..|.|.  |.|.    | .|| |  ... .||.
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

YFVKLDSSKECNGYIERKFHIHSDKDdnssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
. |.| | . | | | ||...  ..|    |  . | . |.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |  
ikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt

GVVDVFQVTKAVRRSKPGAVTT
 .||||.. . .|. .|  | |
rmvdvfnfvtnirqkrpylvqt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 289-504 9.5e-43 141.3 In-house 51-265 (315) alignment
Range on Protein: 289-504
Range on HMM: 51-265/315.0
DKNRSTSYLPRENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTnFGEYF
.|||    .. ..  | |     ...  |.||... ||  |. .| ||.|  .. .|||... ..... |||| .| |. .. . .|| | . . .|.. 
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yGkit

VKLDSSKECNGYIERKFHIHSDkdDNssSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV
| . | .  . |  | . . ..  ||    ...||..| ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| .
vtrkseevnteytvrtlsvvfg..dn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaena

VDVFQVTKAVRRSKPGAVTTL
.||... . ||. . ..| ..
idvynfitgvrqnrikmvqva

0041856 (Phosphotyrosine protein) phosphatases II 289-506 5.7e-32 106.2 In-house 3-159 (182) alignment
Range on Protein: 289-506
Range on HMM: 3-159/182.0
DKNRSTSYLPRENFLvtlkeNNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCgleedgeesCYQYWADSEttnfgeyfvklds
|||| . .|| .. .     .. ||||... |..  . ||..| |...|  ||..|. ......||.|.         ...||.. .             
dknrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.............

skecngyierkfhihsdkddnssSWDLIQLQVTDWPQDGVVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQ
                           ||.. . || .||   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |....
.......................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vslee

VTKAVRRSKPGAVTTLVY
. | ||. .||.|.|. .
avklvrsrRpgmvitpnq

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 290-502 9.9e-33 108.0 In-house 59-267 (290) alignment
Range on Protein: 290-502
Range on HMM: 59-267/290.0
KNRSTSYLPRENFLVTLKE--NNGYINASYLSGYreKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE--TTNFGEYFVK
|||       .   | ||.  .  |. | |. |   |  ||..| ..|.|. |.|.|... ||.|||||| | |||   | ||. . |  .  |||. | 
knrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvl

LDSSKECNGYIERKFHIHSDKDdNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VV
   ... .  | .|     ||| .  .  |  |..  ||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .
cseeddkdaniikktlsvrdkd.sGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkel

DVFQVTKAVRRSKPGAVT
|. .. .|.|.|. ..| 
dlldlvralrnsrlnsvq

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 302-490 3.7e-16 53.7 In-house 60-251 (312) alignment
Range on Protein: 302-490
Range on HMM: 60-251/312.0
FLVTlKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKE------CNG
| ..  ..| || | ..      . |...|.|..||.  ||.. .    ..|..|||. ||| | | .| .|     .. .. |  ..  |       . 
ftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskd

YIERKFHIHSDKDDnSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVT
 |  .      |        | . | . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| . 
kithrvlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvll

subfamily_egg_pd Subfamily egg 304-478 1.7e-17 58.1 In-house 68-228 (307) alignment
Range on Protein: 304-478
Range on HMM: 68-228/307.0
VtlkennGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDgeESCYQYWAD--SETTNF--GEYFVK---LDSSKECNGYI
        .| | ...|      ||.||.|.|||  |||.|.   .|  ||||    |   | |  ||    |..  .  | . ..   .||  .    .
d......dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrv

ERKFHIHSDkddnSSSWdLIQLQVTDWPQDGVVREPRTVLQVIddvihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLEQC
 .   . .|          ..    |. . . |  |  ||. .     |.      ||||.. . ||....  .. | | . 
tklklvGgd....deer.flehwqgdvnnssdvysplrvlrkl.....rnl...skpvvvqdilGvskaatlvaieiallsl

subfamily_eak_pd Subfamily eak 304-401 1.6e-08 28.4 In-house 72-171 (332) alignment
Range on Protein: 304-401
Range on HMM: 72-171/332.0
VTLKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE--TTNFGEYFVKLDSSKECNGYIERKFH
 . ....|||||| .      . .|..  . ..    ||.|... |  |||.|    | . |   .|. |      .|| . |.  .  . | .  |.. 
ssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrlle





subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 305-496 6.6e-20 65.9 In-house 61-246 (281) alignment
Range on Protein: 305-496
Range on HMM: 61-246/281.0
TLKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET--TNFGEYFVKLDSSKECNGYIERKFHI
  |.   || | |.     |. .|..| | |.|  |||.|| . . .|||||| . |   | | .|.        .| .. |. . |   .  .  .. .
pnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl

HSDKDDNssswDLIQLQVTDWPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG-VVDVFQVTKAVRRS
  . .       . .    .||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| .
syegetr....lithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 306-357 7.3e-10 32.9 In-house 66-117 (347) alignment
Range on Protein: 306-357
Range on HMM: 66-117/347.0
LKENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLC
  . ..|||||..     .| .|..| |. .| ||||||.   ||. .| . 
addvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_PTPRD_pd Subfamily PTPRD 307-503 3.9e-62 205.7 In-house 73-266 (564) alignment
Range on Protein: 307-503
Range on HMM: 73-266/564.0
KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIhSDK
.|.  |||||.. |||..||.| .| |...| .|||.|. ....| ||||  ||| |.. | .|| ...|...||. |.| ...| . |. |.| . ..|
degsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkk

DdNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
. .|.|    | . |.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | |
k.ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 307-509 1.1e-42 141.1 In-house 66-267 (281) alignment
Range on Protein: 307-509
Range on HMM: 66-267/281.0
KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSE-TTNFGEYFVKLDSSKECNGYIERKFHIhsd
..|. ||||....||...|..|..|.|. ..  .||.|....|||||||.    | |   |..|| | . ....|.. ||  ...| . ||||||..   
nkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...

KDDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTL
. ... . .. ||. | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |.
eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

VYTRY
|  ..
vqyef

subfamily_CG42327_pd Subfamily CG42327 307-439 3.3e-17 57.1 In-house 53-187 (319) alignment
Range on Protein: 307-439
Range on HMM: 53-187/319.0
KENNGYINASYLSGYREKKA-FIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETT----NFGEYFVKLDSSKECNGYIERKFH
.... |..|||. ||.. .. .| || ...... |||... . .   || |. | | | . | .|.  .||      .|.. | |   .  . |.   . 
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

IHsdKDDNSSSWDLIQLQVtDWPQDGVVREPRTVLQVI
..  . |.. | .|      .|.. .|  |..... ..
lk..rvdkeesrelthywy.kwleaevPaeeaaliaml

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 307-429 1.7e-16 54.7 In-house 10-127 (130) alignment
Range on Protein: 307-429
Range on HMM: 10-127/130.0
KENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEescyqYWADSETTNFGEYFVKLDSS-KECNGYIERKfHIHSD
 ..| |||||..      . .. .| |. .|. |||||...  |  .|.|  .||. |     || |||  .. |  . . .. ..   .|. . ... .
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikas.nleie

KDDNSSSWDLIQLQVTDWPQDGVV
.| | |   |  .|...|| ||  
sdlneshqaltmfqisnwpsdgtt

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 308-503 1.4e-36 121.0 In-house 27-224 (237) alignment
Range on Protein: 308-503
Range on HMM: 27-224/237.0
ENNGYINASYLSGYRE-KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSET-TNFGEYFVKLDSSKECNGYIERKFHIHSD
 .  ||||.|| |.    | .| || |....  |||.|. . | | |||| || |  |. |..|| ...  . .| . | |   .|   |  | . .   
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskr

KDDNsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
   .     . | | | ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . |
ltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt

0043147 (Phosphotyrosine protein) phosphatases II 308-510 1.2e-28 95.3 In-house 3-153 (172) alignment
Range on Protein: 308-510
Range on HMM: 3-153/172.0
ENNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLeedgeescyqywadsettnfgeyfvkldsskecngyierkfhihsDKD
|.. |||||||..|.  . ||. | |. ||  |||.|. ......||.|..|                                              .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

DNSSSWDLIQLQVTDWPQDGVVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLVY
    .   ||.. . ||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||..  .
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsq

TRYM
 |. 
yrfl

0046846 (Phosphotyrosine protein) phosphatases II 308-509 9.8e-28 92.5 In-house 10-164 (176) alignment
Range on Protein: 308-509
Range on HMM: 10-164/176.0
ENNGYINASYLSGYRekkaFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFgeyfvkldsskecngyierkfhihsdkd
..  ||||... |.|    .|. | |. .|  ||..|. .....|.|.|. . | |  .|..|| . |. ..                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

dnssswdliQLQVTDWPQDGVVREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLVY
         | ....||  ||    . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.|  .
.........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

TRY
 |.
yrf

0051429 (Phosphotyrosine protein) phosphatases II 309-505 2.2e-35 118.0 In-house 3-212 (272) alignment
Range on Protein: 309-505
Range on HMM: 3-212/272.0
NNGYINASYLSGYRE---KKAFIIAQSPMKNTARDFWKMiVDYKVSAIVMLCGLEEDGEESCYQYWA------------DSETTNFGEYFVKLDSSKECN
 .|||||....||     ..... .. |...||.|||..  ......||.|...|| | . |..||.            . .| ..| ..|.| | . ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKFHIHSDKDDNSSsWDLIQLQVTDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------
 || |.. ..   . . .   . .|. |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        
dyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFQVTKAVRRSKPGAVTTLV
.... . .|.  |||| |  
leeaveelraqrpgavqtee

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 309-481 4.4e-21 69.9 In-house 72-249 (305) alignment
Range on Protein: 309-481
Range on HMM: 72-249/305.0
NNGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEY----FVKLDSSKECNGYIERKFHI
   || | |.|   . | || .|.|...|  ||| | .. || || ||| | | | . |..|.|  | .. .| |      ||..||.. .   . | ..
pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakv

HSDK----DDNSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
   .       ...    .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  | 
tetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllag

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 309-503 1.3e-20 68.7 In-house 45-244 (290) alignment
Range on Protein: 309-503
Range on HMM: 45-244/290.0
NNGYINASYLSgYREKKAFIIAQSPMKNT-------ARDFWKMIVDYKVSAIVMLCGLEEDGEE----SCYQYWADSET--TNFGEYFVKLDSSKECNGY
|..|| |.... . .  ..|. ||| ...         .|| |. . ||  .||||  ||  ..    .| .|  .|.    .|.   ||  |  . .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKFHIHSDKDdnsSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVR
..|.  .. |..     . .   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|
etRelvvkfdde...eeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

RSKPGAVTT
. .  |.|.
kqralaits

0044763 (Phosphotyrosine protein) phosphatases II 309-510 4.5e-20 67.5 In-house 17-163 (178) alignment
Range on Protein: 309-510
Range on HMM: 17-163/178.0
NNGYINASYLSGYrekkaFIIAQSPMkntaRDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETtnfgeyfvkldsskecngyierkfhihsdkdd
   |||||.  ..     ..... |.     |..... ......||.|..  | | ..|..|| ...                                 
rsdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

nssswdlIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLVYTR
       || . . .| .||   .. .|... . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|..  . |
.......iqylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

YM
..
qL

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 309-409 5.7e-13 42.9 In-house 89-192 (349) alignment
Range on Protein: 309-409
Range on HMM: 89-192/349.0
NNGYINASYLSGY--REKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADsetTNFGEYFVKLDSSKEC----NGYIERKFHI
 . |||| ||.      .| .|  | |.  |  ||.|.|.  .|  .. |   .| . | |..|| .    .. .. |||  | .     .|   | .. 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe...lsysnitvklqnsslyianvqGnslrvstv

HSDKDDN
. ...||
kdtdndn

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 309-401 4.1e-08 27.1 In-house 59-154 (332) alignment
Range on Protein: 309-401
Range on HMM: 59-154/332.0
NNGYINASYLSGYREKKAFIIAQSPMKN-TARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS--ETTNFGEYFVKLDSSKECNGYIERKFH
.. . |||.. || .| |.|.||.|... |   ||.|. . | | |...  ..|  .  .    .|   | . . |.  |     | .  | ||| 
kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksflhefgaksleecelkakicrkfw

0036282 (Phosphotyrosine protein) phosphatases II 310-510 1.1e-31 105.3 In-house 2-162 (174) alignment
Range on Protein: 310-510
Range on HMM: 2-162/174.0
NGYINASYLSGYREKKAFIIAQSPMKntardFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADsettnfgeyfvkldsskecngyierkfhihsdkDDN
. |||||.|....  . .|. | |..     ||.|. .......|||. ..|.| . |..|| .                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

SSSWDLIQLQVTDWPQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLVYTRY
. .   ||.. . || .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.|  . |.
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

M
 
l

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 310-503 2.2e-31 103.9 In-house 36-226 (239) alignment
Range on Protein: 310-503
Range on HMM: 36-226/239.0
NGYINASYLSGYR-EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSeTTNFGEYFVKLDSSKECNGYIERKFHIhSDKDD
. |||||||  |    ||.| .|  .. .. |||.|. . .   |||| || |  .. |.||| || |... .  | |  ..    || | | . |.  .
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtfvm.sqvgq

nSSSWDLIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
 .    . | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | |
.teeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 310-503 2.2e-31 103.9 In-house 35-225 (239) alignment
Range on Protein: 310-503
Range on HMM: 35-225/239.0
NGYINASYLSGYR-EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSeTTNFGEYFVKLDSSKECNGYIERKFHIhSDKDD
. |||||||  |    ||.| .|  .. .. |||.|. . .   |||| || |  .. |.||| || |... .  | |  ..    || | | . |.  .
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtfvm.sqvgq

nSSSWDLIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
 .    . | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | |
.teeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt

0051082 (Phosphotyrosine protein) phosphatases II 310-505 2.3e-23 77.9 In-house 3-140 (151) alignment
Range on Protein: 310-505
Range on HMM: 3-140/151.0
NGYINASYLSGYrekkaFIIAQSPMKntarDFWKMIVDYKVSAIVMLCGLEEDGeeSCYQYWADSEttnfgeyfvkldsskecngyierkfhihsdkddn
..|||.||. |.     ... . |.     ||.... ......||.|...|| |   |..|. . .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sssWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLV
    ........|||  |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|..  
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 310-505 2.1e-20 68.0 In-house 67-258 (288) alignment
Range on Protein: 310-505
Range on HMM: 67-258/288.0
NGYINASYLSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWAD--SETTNFGEYfvkLDSSKECNGYIERKFHIHSDKD
. ||.|  .|  . |. .| ||.|.. |   .|||...  |  ||||| | | | |   .|.     |.. .| .       |. .  |..  ..   . 
dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllri

DNSS---SwDLIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
 .        . .| . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..| 
skegeekv.ivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqte

V
 
m

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 318-505 5.5e-27 89.2 In-house 229-425 (440) alignment
Range on Protein: 318-505
Range on HMM: 229-425/440.0
LSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEdgeESCYQYWA-DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDdnssSWDLI
. ||  |.||| .| |.  |  |||... ||..|.|.||  |..    .|  ||  .. .  || . |    |.. |    | . ..  ..      .. 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee....vheir

QLQVTDWP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAV
|..|  ||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  |
qfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfv

TTLV
 || 
ptlt

0049260 (Phosphotyrosine protein) phosphatases II 318-510 2.8e-26 87.4 In-house 2-142 (152) alignment
Range on Protein: 318-510
Range on HMM: 2-142/152.0
LSGYREKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWadsettnfgeyfvkldsskecngyierkfhihsdkddnssswdliQ
..||. ...||..| |. ||. |||.|. ......||||. |.|.|.. |.||.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

LQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLVYTRYM
 . . || .||   .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||..  . |. 
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 323-506 5.7e-17 56.5 In-house 3-192 (199) alignment
Range on Protein: 323-506
Range on HMM: 3-192/199.0
EKKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQV
 .. .| .| |...|  |||.|. .     |||.   . . |     ||.  .| |...|   |   .      |    . . ..     |. .. . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLVY
| | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...| .
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 324-506 6.6e-17 56.3 In-house 3-191 (198) alignment
Range on Protein: 324-506
Range on HMM: 3-191/198.0
KKAFIIAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWA--DSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVT
.. .| .| |...|  |||.|. .     |||.   . . |     ||.  .| |...|   |   .      |    . . ..     |. .. . | |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLVY
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...| .
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 329-506 2.3e-21 70.5 In-house 95-276 (302) alignment
Range on Protein: 329-506
Range on HMM: 95-276/302.0
IAQSPMKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADS--ETTNFGEYFVKLDS-SKECNGYIERK------FHIHSDKDDNSSSWDLIQLQ
    | |.|   .| .| .|.|. .| ||.. ||.|. | .|..|   .. .||.| ||  |  .. . . ..|        |. .|  .     .  |.
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

VTDWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLVY
 . ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| .   
fsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 329-492 8.8e-11 36.4 In-house 39-195 (255) alignment
Range on Protein: 329-492
Range on HMM: 39-195/255.0
IaqspmknTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGV
.       |   |...||  | . .|||| ..|.| | | .|.            |.. ..|  .  . |  .| |   .     ..   . . |..   
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

VREPRTVLQVIDDVihRQQKigggPVVVHCSDTVSRSGVYCsvsigleqckaegV-------------------VDVFQVTKA
 ...| .|...  |  |. |    .||||||  . ||  .              .                   .|  .. . 
Pelareilnilkvv..rdsk....svvvhCstGiGrsaafv.............laelvyqkmirsldttetveldylsllee

subfamily_hpo-7_pd Subfamily hpo-7 334-471 2.3e-09 31.6 In-house 43-174 (263) alignment
Range on Protein: 334-471
Range on HMM: 43-174/263.0
MKNTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWADSETTNFGEYFVKLDSSKECNGYIERKFHIHSDKDDNSSSWDLIQLQVTDWPQDGVVREPR
. .|   |...||  | . .||||  .|.| | | .|.            |.. ..|  .  . .  .. |  ..     .. . . . |..   ....|
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

TVLQVIDdvIHRQQKigggPVVVHCSDTVSRSGVYCSV
 .|....  . |. |    ..|||||  . ||  .  .
eilnilk..varnsk....slvvhcstGiGrsaafsva

0048179 (Phosphotyrosine protein) phosphatases II 403-509 4.1e-11 38.3 In-house 48-136 (144) alignment
Range on Protein: 403-509
Range on HMM: 48-136/144.0
HsdkddnssswdLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVT
.            ||.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...        .| .| ...... . ||.  ||||.
e...........giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavp

TLVYTRY
.  . |.
npgqlrf

0048076 (Phosphotyrosine protein) phosphatases II 409-510 1.9e-11 39.3 In-house 41-135 (145) alignment
Range on Protein: 409-510
Range on HMM: 41-135/145.0
NSSSWDLIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLVYTR
.  .   ||.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |..... . ||.  ||||..  . |
ellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlr

YM
..
fl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 409-475 3.4e-06 20.6 In-house 214-289 (349) alignment
Range on Protein: 409-475
Range on HMM: 214-289/349.0
NSSSWDLIQLQVTDWPQDGVVREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIGL
... . |.|||| .|.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 413-473 3.2e-06 21.1 In-house 215-284 (350) alignment
Range on Protein: 413-473
Range on HMM: 215-284/350.0
WDLIQLQVTDWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSI
. . ||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDs

PTPc_DSPc_SM00012 417-504 1.4e-19 65.6 In-house 4-93 (105) alignment
Range on Protein: 417-504
Range on HMM: 4-93/105.0
QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTL
....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_CG42327_pd Subfamily CG42327 450-503 6.6e-07 23.3 In-house 246-300 (319) alignment
Range on Protein: 450-503
Range on HMM: 246-300/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTT
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 455-501 3.3e-06 21.4 In-house 2-48 (69) alignment
Range on Protein: 455-501
Range on HMM: 2-48/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAV
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv