Gene PTPRD-54 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP111_AA protein Get Run
AqueP111_AA_818-957 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 186-261 8.4e-15 47.9 Pfam-A 1-79 (85) alignment
Range on Protein: 186-261
Range on HMM: 1-79/85.0
SAPTSLTKLNKTTTTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVKGSSNnAATLNGLREGTTYSITVRAYQQL
|||. |.  . |.|..|.||.. .  ... .|| | . .....   ....|.....  .||.||..||.|...|.|. . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 460-548 8.2e-12 38.3 Pfam-A 1-84 (85) alignment
Range on Protein: 460-548
Range on HMM: 1-84/85.0
SPVTSLSVSNVSTTGIRVKWTIP-SSDNYVTYYTISYTPSCPQLssVNERVSVGPHqstTRySYTLIGLYSGMNYTITVRAGNVLGGSKL
|... ||||.|..| ....|. | . .  .|.|.. | ..  .   .  ...| ..   |. |.|| ||  |..|...|.| |  |... 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt...tt.svtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 564-643 4.6e-11 35.9 Pfam-A 3-85 (85) alignment
Range on Protein: 564-643
Range on HMM: 3-85/85.0
PSSIQVFQVNSTANRFTWNEVNcsERNGLITGYTVIISNS-----SITYNLTSTERYIILNDLVFGTEYNISVAAINSVGRGPFS
|. ..| .|.||  ...|.. .  ...| ||||.|  ...     . ......|..  .|..|  ||||...|.|.| .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 805-958 1e-51 170.9 In-house 3-156 (305) alignment
Range on Protein: 805-958
Range on HMM: 3-156/305.0
PVSVDELGTHV---ATCHSNGFDEQYESLYTGiDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMK
....|.| ...    . ...|...||.|||.  .. . .| .|.|.| ||.|.||..||.||||... .||  ...||||||.|||....|.|..|||.|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNEQ
.|..||||||..||...|||.|.|.|| |.||.||||.  .|. .||.|.|.|..|.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek

subfamily_PTPRD_pd Subfamily PTPRD 805-957 1.4e-46 154.3 In-house 4-155 (564) alignment
Range on Protein: 805-957
Range on HMM: 4-155/564.0
PVSVDELGTHVATCHSN---GFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMK
|..|.|| .|||  ..|    |.|.|... .|   ..    ...| | ||..||. || .|..| . ..    . .|||||.|||| .....||.|||..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDHFGSFTVTLTNE
.|. ||||..|...  .|||.|.|.| .| ||..|||. .  . ..|..||||..|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg..tetygeltVtleee

subfamily_PTPRB_pd Subfamily PTPRB 805-958 1.4e-39 130.9 In-house 6-160 (293) alignment
Range on Protein: 805-958
Range on HMM: 6-160/293.0
PVSVDELGTHVATCHS---NGFDEQYESLY-TGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPM
|...... .||.. ..    .| |.||.|   | |. . .  ...|.| ||..||  || .|. ||. .  |  . .||||.||.||.| ..|||.|||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGPl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESdHFGSFTVTLTNEQ
 .|. ||||..|..|   |||.|.| |. | |||.|||. . .   .|. .|||..|.
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaee

subfamily_PTPRA_pd Subfamily PTPRA 805-956 1.9e-39 130.5 In-house 13-164 (330) alignment
Range on Protein: 805-956
Range on HMM: 13-164/330.0
PVSVDELGTHVAT---CHSNGFDEQYESLYT-GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPM
|. |..|   .       .. | |....| .  |.  . .  .|||   ||. ||  || .|.||.. .  .  . .|||||.||||   .||||.||| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPk

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDHFGSFTVTLTN
..|. ||||.||. |  .|||.|.|||  ..||.||||.    .  .|  .|.. .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirveved

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 805-957 7.2e-35 115.5 In-house 4-155 (319) alignment
Range on Protein: 805-957
Range on HMM: 4-155/319.0
PVSVDELGTHVATCHSNG---FDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMK
.. |.|| ... . .|.|   ...... | .. ..      .|||   ||..||  ||  |..|..     . . .|||||.||||   .|||| |.|..
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAEsdHFGSFTVTLTNE
.|. ||||..|.|.   .||.|.|.|  | |...|||.   |  ..| ..||| .|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfe..eyGrlivtleee

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 805-957 1.3e-34 114.6 In-house 5-155 (315) alignment
Range on Protein: 805-957
Range on HMM: 5-155/315.0
PVSVDELGTHVAT---CHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILaPNRKLDmCQREYINASYIDGYSSSNKFIASQGPMK
|. .|.| |.||       ||| ..|||.  |  .   .  . ||   ||. ||  ||  |. | |  . |  . .|.||..||||.  ...||.|||  
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaqgpnv

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraeSDHFGSFTVTLTNE
 .. |||||...|.   |||.||| || |.|.|.|||.       .| .|||. .|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkse

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 805-898 9.8e-13 42.1 In-house 4-95 (95) alignment
Range on Protein: 805-898
Range on HMM: 4-95/95.0
PVSVDELGTHVATCHSNG---FDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcqreYINASYIDGYSSSNKFIASQG
|. |  . .||   |||    ||... |.         .|  | |   ||| ||  ||  |..|. .|  |     |||| ..|||.  | .||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 806-958 1.2e-47 157.2 In-house 2-156 (290) alignment
Range on Protein: 806-958
Range on HMM: 2-156/290.0
VSVDELGTHVATCHS---NGFDEQYESLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYSSSNKFIASQGPMK
. ||..| .||. |.   .|| .|...| .|  ..   .|  ..|   |||.|| |||||||.| |  .   |. |||||.||.||. ....|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraES-DhFGSFTVTLTNEQ
.||||||.||||||   |||.|| .|  | || ||||.   .. . .| |...|.||.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka.ygefsikllnee

subfamily_PTPRG_pd Subfamily PTPRG 806-957 5.5e-41 135.4 In-house 1-155 (563) alignment
Range on Protein: 806-957
Range on HMM: 1-155/563.0
VSVDELGTHVATCHSNG---FDEQYESLYTGIDKR---CIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQrEYINASYIDGYSSSNKFIASQGP
| |.|.  ||| .|..|   |.|..|.| . . ..   .    ..||   ||  ||. ||  |. |.|    .    .||||.|||||  |..|||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|.|. ||||.||...   |||.|||.| .. ||..|||.   || ..|...|||..|
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtliee

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 806-958 1.4e-40 134.1 In-house 2-151 (287) alignment
Range on Protein: 806-958
Range on HMM: 2-151/287.0
VSVDELGTHVATCHS---NGFDEQYESLYT--GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnrkldMCQREYINASYIDGYSSSNKFIASQGPM
..|...|  ||. |    .|| .|.  |      ..   ..  ..|   ||...| |.|..|..|        .. .||||..||||.....||....||
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAesDHFGSFTVTLTNEQ
 .|...||.||.....  |||....|| ....| ||||....    .| ....|.||.
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 806-957 3.9e-37 123.0 In-house 2-153 (318) alignment
Range on Protein: 806-957
Range on HMM: 2-153/318.0
VSVDELGTHVATCHSNG---FDEQYESLYTGIDKRCI-IGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMK
.||..| .||.  ...|   ..|.|| |    ..       .. | | ||. ||. ||. |. | .    .  . .||||.||||| .....||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|. ||||..|. .   |||.|...| .| |...|||.   .| ..|. .|.|..|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkee

subfamily_PTPN6_pd Subfamily PTPN6 806-958 2.4e-35 117.0 In-house 11-164 (306) alignment
Range on Protein: 806-958
Range on HMM: 11-164/306.0
VSVDELGTHVATCHSNGFDEQYESLYTGID---KRCIIGYNEENTAFNRFKNITVYDDNRIILApnrKLDMCQREYINASYIDG--YSSSNKFIASQGPM
  |.||  .  . . .|| |..|.| .           |   ||.  ||.|||  .|..|.||.   . .. . .||||.||..   .|....||.|| .
qrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgcl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDhFGSFTVTLTNEQ
..|. ||||..|||.   |||.|.  | .|.|| .|||.  .... .|. .|| ..|.
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek

subfamily_Ptp69D_pd Subfamily Ptp69D 808-957 6.6e-38 125.5 In-house 6-155 (307) alignment
Range on Protein: 808-957
Range on HMM: 6-155/307.0
VDELGTHVATCHS---NGFDEQYESLY-TGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKT
.|.| . . . .     |. . ||.|  . ||| . .. ..||.  ||...|. .|..|..|..    .  . .|||||.| ||  ..||||.|.|.  |
iddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveat

LVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraESDHFGSFTVTLTNE
. ||||.|.. .   |||..||.| .. ||..|||.   .  ..|.  |.| .|
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvse

subfamily_PTPN9_pd Subfamily PTPN9 808-955 3.9e-34 113.0 In-house 3-149 (297) alignment
Range on Protein: 808-955
Range on HMM: 3-149/297.0
VDELGTHVATCHSNGFDEQYESLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVD
..|| ..|   . .|  ..|. .    .  .        |   ||....  ||. |. ||   . .  . .||||...|||   . ||| |||.|||  |
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsd

FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLT
|||..|... . |||.| . |  . || ||||... .|..||...|.  
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 809-958 2.6e-73 241.4 In-house 3-152 (301) alignment
Range on Protein: 809-958
Range on HMM: 3-152/301.0
DELGTHVATCHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFW
..||||||..|||.|.|||..|..| ||.|..|..|||.|.||||||||||||||||.|...||.|||||||||||||||...||||.||||||||||||
edlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNEQ
|||||||||||||||||||||||||||||||..|||..|| |||||.|||
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 813-957 1.9e-39 130.4 In-house 13-155 (288) alignment
Range on Protein: 813-957
Range on HMM: 13-155/288.0
THVATCHSNGFDEQYESL-YTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLI
..      .|| |.|.||   . .|   .| . .|   ||..||  || .|. |      .  . .|||||||||. ...|.||.|||. .|. |||.|.
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaESDHFGSFTVTLTNE
...|   |||.|.| || |.|||.|||..  .  ..||.||||...
yenktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlves

subfamily_PTPRK_pd Subfamily PTPRK 815-955 1.5e-36 120.9 In-house 16-147 (314) alignment
Range on Protein: 815-955
Range on HMM: 16-147/314.0
VATCHSNGFDEQYESLYTGIDKrciiGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQE
. .... || |.||||. | |       ..|| . ||...|  ||  |..| .    .  . .||||..||.|  ...||. |||...|. |||||...|
lkraegygfkeeyeslfegwda....akkdenreknrsgdilaydrsrvflitid..gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KPVSIVMVTNLKEGTKSKCEQYWPNgraESDHFGSFTVTLT
.  ||||.|.|.| .. || .|||.   .....| . |.| 
ncasivmltelvevgrvkClkyWPe...dtevygdikvelv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 817-957 1.5e-35 117.9 In-house 23-163 (298) alignment
Range on Protein: 817-957
Range on HMM: 23-163/298.0
TCHSNGFDEQYESLYTGID----KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIW
. .  |...... | .. .    .   .. ..||   ||. .|  .|  |..|  .   .  . .|||||....|. .| |||.|.|...|..||||...
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

QEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDHFGSFTVTLTNE
.|.  .|||.|||.|  | |...|||. .  ....|..||.| ..
eedigtiVmltnleeldktkyhkywPdeg..ketygeitvsllsk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 817-886 9e-06 19.3 In-house 18-85 (440) alignment
Range on Protein: 817-886
Range on HMM: 18-85/440.0
TCHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDG
   |  |....  | .|. . . |    .|   ||..|| .|| .|..|   .   . . .|||||||.|
nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevk..gvpdsdyinasying

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 818-940 5.4e-25 82.6 In-house 17-145 (392) alignment
Range on Protein: 818-940
Range on HMM: 17-145/392.0
CHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
 ||  | |..  |      .  .. .| |   ||.|||  || .|..|      |. ...|.|||||... . . .||||||   .| ||||...||.. 
rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkle..viddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

SIVMVTNLKEGTKS----KCEQY----WPNG
.|.|||.|||| |      . |.    ||. 
tiamvtklkegdkgddartvaqfhftewPdk

0039614 (Phosphotyrosine protein) phosphatases II 819-957 6.2e-38 126.3 In-house 30-163 (297) alignment
Range on Protein: 819-957
Range on HMM: 30-163/297.0
HSNGFDEQYESLYTGIDKrCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMcQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPV
 ........|.|.  ..  . |.. .||  .||.|.|  ||..|..| |... |.    ||||||.|||.  ..||||.|||...|. ||||..|...  
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

SIVMVTNLKEGTKsKCEQYWPNGRAesdHFGSFTVTLTNE
.|||.|.|.|  . ||.||||.       .| |||||...
vivmLtklvelgr.kcaqywpeegg...tygdftvtllkv

0043336 (Phosphotyrosine protein) phosphatases II 819-957 3.6e-37 123.7 In-house 18-151 (278) alignment
Range on Protein: 819-957
Range on HMM: 18-151/278.0
HSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
   .. ...|.|..     . |.. .||  .||.|.|  || .|..| .  .       ||||||.|||. ..||||.|||...|. ||||..|...  .
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMVTNLKEGTKSKCEQYWPngrAESDHFGSFTVTLTNE
|||.|.|.|  . || ||||    .|  .| |||||..|
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllke

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 819-957 5.7e-37 122.4 In-house 13-149 (281) alignment
Range on Protein: 819-957
Range on HMM: 13-149/281.0
HSNGFDEQYESLYT-GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
...|| |.||.|.  |.|.     ...||.  ||..||. ||  |. ..|| .  ..  .||||....||.. ...||.|||. ..||.||...|..|  
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SIVMVTNLKEGTKSKCEQYWPNGRAeSDHFGSFTVTLTNE
 |||||.  |. | || .|||.... . ..| .||. |.|
aivmvtreieagklkChrYWPddns.elkygdvtvkstae

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 819-955 2.3e-34 113.7 In-house 17-151 (315) alignment
Range on Protein: 819-955
Range on HMM: 17-151/315.0
HSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
|.  | |..  |      |  .. ...|   ||.|||  .| .|..|      |  ...||||||| .. . . .|||||| | .. ||||...|||. .
htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklev..iddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLT
|||||...|| | || ||||. .|.| .|||. |.| 
ivmvtkkqegdkikcrqywPdrkadsvefGsikvell

0051299 (Phosphotyrosine protein) phosphatases II 821-957 6.8e-40 132.7 In-house 23-156 (288) alignment
Range on Protein: 821-957
Range on HMM: 23-156/288.0
NGFDEQYESLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
.|. |..| |.  . |  . ... .||   ||...|  ||..|..| .  .  .    |||||||||| ...|||| |||...|. ||||..|...   |
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvI

VMVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
||.|.| |  . ||.||||.   .|  .| .||||..|
vmltklvelgrekcaqYwpl..ggsltygditvtllse

0040438 (Phosphotyrosine protein) phosphatases II 821-957 2e-39 131.1 In-house 18-150 (317) alignment
Range on Protein: 821-957
Range on HMM: 18-150/317.0
NGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
... |..| |.. .   . ... .||  .||...|  ||..|..| |  .       ||||||.||.. ..|||| |||...|. ||||..|...  .||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
|.|.|.|  . ||.||||.   |. ..| |||||..|
mLteleelgrekcaqYwpl..getltygdftvtllse

0045450 (Phosphotyrosine protein) phosphatases II 821-957 1.1e-35 119.3 In-house 27-172 (307) alignment
Range on Protein: 821-957
Range on HMM: 27-172/307.0
NGFDEQYESLYTGIDK---RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdMCQREYINASYI--------DGYSSSNKFIASQGPMKKTLVDFWR
.|. ...|.|.   ..    . |.. .||  .||.|.|  ||..|..| .  .  .    ||||||.        ||| ...|||| |||...|. ||||
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESDHFGSFTVTLTNE
..|...   |||.|.|.| .. || ||||.   |.  .| |||||..|
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllse

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 821-953 5.2e-19 62.9 In-house 27-155 (310) alignment
Range on Protein: 821-953
Range on HMM: 27-155/310.0
NGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
.|.  ||  | .  |        ...   ||. .. . |. |. |  ..       .|| | |.      . || ||||...|..||||.|.||.  ||.
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MVTNLKEGTKSKCEQYWPNGrAESDHFGSFTVT
.. .  |  . ||  |||     .. .|   ||
llckvgeegrpkcvgywpsl.gvtetygcirvt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 821-950 2.6e-12 41.4 In-house 19-141 (288) alignment
Range on Protein: 821-950
Range on HMM: 19-141/288.0
NGFDEQYESLYTGIDKRCIIGYNEeNTAFNRFKNITVYDDNRIILApnrklDMCQrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
.| . .|.    .  .. |  . . |.. .|..|.   |  |. |      | ..  ||.|  .      ...| .| |.. |.  .|... ..    ||
eglkkeyrdspneasidiidsfia.nptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyiv

MVTNLKEGTKSKCEQYWPNGRAESDHFGSF
|...| |  | | ..|.|    |. ..| .
mlcellekGkeksaeyfPsklGekarigrl

0050432 (Phosphotyrosine protein) phosphatases II 822-957 2.9e-39 130.6 In-house 43-175 (308) alignment
Range on Protein: 822-957
Range on HMM: 43-175/308.0
GFDEQYESLYTGID-KRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDmCQREYINASYIDGY--SSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
...|..| |.   .   . ... .||  .||.|.|  || .|..|      |     ||||||.|||   ...|||| |||...|. ||||..|...   
lleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMVTNLKEGTKSKCEQYWPNGRA-ESDHFGSFTVTLTNE
|||.|.| |  . ||.||||.    .| ..| |||||..|
IvmLtklvengrekcaqYwplelgggsleygkftvtllse

0046845 (Phosphotyrosine protein) phosphatases II 823-957 1.8e-38 128.0 In-house 2-142 (284) alignment
Range on Protein: 823-957
Range on HMM: 2-142/284.0
FDEQYESLYTGIDK---RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKlDMCQREYINASYIDGY-----SSSNKFIASQGPMKKTLVDFWRLIWQE
..|..| |.    |    . ... .||   ||.|.| .||..|..| .  . |.   .||||||.|||      ...|||| |||...|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPVSIVMVTNLKEGTKSKCEQYWPNGrAESDHFGSFTVTLTNE
.   |||.|.| |  . ||.||||.   |. ..| |||||..|
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllse

DSPc_SM00195 823-957 1.8e-37 124.5 In-house 2-135 (263) alignment
Range on Protein: 823-957
Range on HMM: 2-135/263.0
FDEQYESLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
..|..|.| .   .|..  .  ..|.. ||.||| .||..|..| .. |    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
.|. .|  | ||..|||.   ..  ||...|.|...
lteeeengkekcdrywpeesggketfgkisvklvev

PTPc_SM00194 823-957 1.8e-37 124.5 In-house 2-135 (263) alignment
Range on Protein: 823-957
Range on HMM: 2-135/263.0
FDEQYESLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
..|..|.| .   .|..  .  ..|.. ||.||| .||..|..| .. |    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
.|. .|  | ||..|||.   ..  ||...|.|...
lteeeengkekcdrywpeesggketfgkisvklvev

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 823-955 5.7e-28 92.9 In-house 28-153 (297) alignment
Range on Protein: 823-955
Range on HMM: 28-153/297.0
FDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSsnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMV
| |..  | .   .      .  |   .|.|||  || .|..||     |  . .|.|||.. |.    ..|..| ||| |. |||.....|..  |||.
fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

TNLKEGTKsKCEQYWPNGRAESdhFGSFTVTLT
....|..| || .||..    .  ||. .|.|.
nddnerdk.kcaryWsdkgvtt..fGdvsvvll

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 823-940 2e-21 70.9 In-house 22-135 (439) alignment
Range on Protein: 823-940
Range on HMM: 22-135/439.0
FDEQYESLYT-GIDKRCIIGY--NEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
|.| .|.. .   | .||     .| . . ||.|... .|  |..|       . .  |||| ||.||   . .||.||| |.|  |||||....| | |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip..gvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMVTNLKEGTKskceqYWPNG
||.||| |  |     |||  
vmltnlvesyk.....ywpsd

0045098 (Phosphotyrosine protein) phosphatases II 824-957 4.3e-35 116.8 In-house 11-128 (278) alignment
Range on Protein: 824-957
Range on HMM: 11-128/278.0
DEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIIlapnrkldmcqrEYINASYIDGYssSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
 | .. | .||  ..  .  ..| ..||.|.|  || .|..            .||||||||||  ..|||| |||...|. ||||..|...  .|||.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

NLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|.|... ||.||||.   .|  .| |||||..|
elvelgrekcaqywpe..ggsltygdftvtllse

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 825-957 7.3e-35 115.2 In-house 13-139 (283) alignment
Range on Protein: 825-957
Range on HMM: 13-139/283.0
EQYESLyTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmcqrEYINASYID---GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
|... | .  |. . |  ..||  .||...| ..| .|. | .. .      .||||..|     |  ..|.|..|.|...| ||||.....|| ..|||
evlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

VTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|.|.|. . || ||||.    |  .| ||||| .|
ltklqedlrikCsqyWPk..rGsedyGeftvtlrke

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 825-950 5.3e-09 29.9 In-house 33-151 (302) alignment
Range on Protein: 825-950
Range on HMM: 33-151/302.0
EQYESLYTGIDKrCIIgyNEENTAFNRFKNITVYDDNRIilapnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTL---VDFWRLIWQEKPVSIVM
.. ... . ..| | .    .|...|. ... ..|.|..      ||.... .|.||| ..  . ... | .| | ...     .|||...||| ||.|.
kkidtmkvdlek.Cka..fkknlkknqsedvpildsnlv......kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi

VTNLKEGTKsKCEQYWPNGRAESDHFGSF
.   .| .|   ....|.   .  ..|..
lvgeeelkk.tlselfpkksgdykeygkm

subfamily_PTPN3_pd Subfamily PTPN3 826-957 3.2e-30 100.0 In-house 20-149 (280) alignment
Range on Protein: 826-957
Range on HMM: 20-149/280.0
QYESLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKlDMCQREYINASyIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTN
|.| ||    .  . .    || . ||...|. ||. |..|  ... |    .|.|   |.. . .|..||.|||..||  |||...|..|   |||.|.
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

LKEGTKSKCEQYWPNgRAESDHFGSFTVTLTNE
| |  . || ||||.   .. ..|.|.|....|
lverGrvkChqyWPe.tedeleygefsvkceke

0047943 (Phosphotyrosine protein) phosphatases II 830-957 1.7e-37 124.8 In-house 21-144 (273) alignment
Range on Protein: 830-957
Range on HMM: 21-144/273.0
LYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEG
|.  . .  . ... .||  .||.|.|  ||..|..|      ..    ||||||.||| ...|||| |||...|. ||||..|...   |||.|.| | 
llslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvel

TKSKCEQYWPNGRAE-SDHFGSFTVTLTNE
 . ||.||||.   | |  .| |||||..|
grekcaqYwpleggelsltygkftvtllse

subfamily_PTPRN_pd Subfamily PTPRN 833-956 8e-22 72.3 In-house 43-163 (297) alignment
Range on Protein: 833-956
Range on HMM: 43-163/297.0
GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYID-GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
  .. . .. .|.|   || |..  ||..|. |   .. .  . .||||| |      .  .||.|||. .|. |||...|..  | ||..|.|.|   .
aepstkevakaeknvkknrskavlpydhsrvklk..eeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

KCEQYWPNGRAESDHFgsFTVTLTN
.|..|||.  .|  |.  . | |  
qckrywpdeGsevyhi..yevhlvs

subfamily_PTPN14_pd Subfamily PTPN14 834-953 4.3e-28 93.2 In-house 37-157 (300) alignment
Range on Protein: 834-953
Range on HMM: 37-157/300.0
IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmcQREYINASYIDGYSSS--NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
 |  .  . ..||.  ||||..  |.|||. |.|...    . .||||| |    ..   ..|..|||...|. |||...|...   |||.|. .|. | 
edallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KCEQYWPNG--RAESDHFGSFTVT
|. .|.|.   .... .|| | ||
ksfkyfPkleskkktvefgkfkvt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 834-953 1.6e-19 65.0 In-house 21-131 (267) alignment
Range on Protein: 834-953
Range on HMM: 21-131/267.0
IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtksKC
.  ..   . |.| ..||. .   |||.|.||  . .       ||||||..||   |.||. |.|.|.|  ||. .| ..|   ||..|.  ..   . 
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...ni

EQYWPNGRAESDHFGSFTVT
 ..||   ... ..  .|| 
rlfwPPkmgqakkyqdltve

0036941 (Phosphotyrosine protein) phosphatases II 835-957 1.3e-38 128.4 In-house 28-144 (297) alignment
Range on Protein: 835-957
Range on HMM: 28-144/297.0
DKRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
.  . .. ..||   ||.|.|  ||..|..|      |     ||||||.|||. ..|||| |||...|. ||||..|...  .|||.|.| |  . ||.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPNGRAESDHFGSFTVTLTNE
||||.   ||  .| |||||...
qywpleegesltygdftvtllsv

0049772 (Phosphotyrosine protein) phosphatases II 835-931 1.5e-17 59.8 In-house 35-157 (314) alignment
Range on Protein: 835-931
Range on HMM: 35-157/314.0
DKRCIIGYNEENTAFNRFKNITVYDdNRIILapnRKLDMCQREYINASYIDGYsssNKFIASQGPMKKTLVDF----------WRLI--WQEKPVSIVM-
.. . ... ..|   ||...|  .| || ||    .|..    ||||||.||.   .||||.|||.. |.|||          ||..  .. ..  ||| 
eltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------VTNLKEGTKS
                     ..| ...  
rdevladelsrLdaAlgKtpllildgngne

subfamily_PTPN13_pd Subfamily PTPN13 836-954 3.7e-24 80.4 In-house 27-141 (273) alignment
Range on Protein: 836-954
Range on HMM: 27-141/273.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmcqreYINASYIDGYSSSNKF--IASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
..| .| ..||.. ||..|.  ||. |..|  .         |||||.|      ...  ||.|||. .|  |||...|. |   |.|||. ||. | ||
dtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

EQYWPNGRAESDHFGS-FTVTL
..|||. . ..    . ..|.|
hrywPesknkklkvsnrlevel

subfamily_CG7180_pd Subfamily CG7180 836-957 6.8e-24 79.0 In-house 32-148 (296) alignment
Range on Protein: 836-957
Range on HMM: 32-148/296.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQ
  |  |...||   ||  ..  || ||..|      .  . .||||.|.|..   ...|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .
gdCagglrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPNGRaeSDHFGSFTVTLTNE
||||      ..| . | ...|
ywpnks..keqygeifveivee

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 836-923 4.2e-11 37.0 In-house 27-117 (347) alignment
Range on Protein: 836-923
Range on HMM: 27-117/347.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDM---CQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
 ..     | . . || |.  . |. |..|.|..           |||||.|    .|...| .| |. .|. |||...   |   .| . 
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 837-957 3.4e-23 76.7 In-house 48-160 (290) alignment
Range on Protein: 837-957
Range on HMM: 48-160/290.0
RCIIGYNEENTaFNRFKNITVYDDNRIILApnrklDMCQREYINASYIDGYSssNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
| |.  | | .  ||.|...  |  |.||      |  . .|. | |..|      || .||..|.| .|.||.. |||   |||. .| |  |.|||||
rkifdkntefk.knrykdvvcndktrvilk.....dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPNGRAESDHFGSFTVTLTNE
.|.   |   ||..||. ..|
ypekeGevltfGeitvlcsee

0040439 (Phosphotyrosine protein) phosphatases II 838-957 6.5e-33 109.8 In-house 3-118 (249) alignment
Range on Protein: 838-957
Range on HMM: 3-118/249.0
CIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
. ... .||   ||...|  || .|..| . ..|  .   |||||||||| ....||| |||...|. ||||..|...  .|||.|.|.|  . ||.|||
ysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PNgrAESDHFGSFTVTLTNE
|.   .|  .| |||||...
pl..ggsleygdftvtllsv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 838-952 1.1e-17 58.6 In-house 29-142 (281) alignment
Range on Protein: 838-952
Range on HMM: 29-142/281.0
CIIGYNEENTAFNRFKNITVYDDNRIILAPNrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
| .  .  |   ||. || . |  |. |  .   .    .|| | ||        .| .||| |.|  ||||.||||.  .|||. .. |  . || .|.
ctvfnqpvnnkknrylnipcldisrvqlkvk.mpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PNGRAESDHFGSFTV
|       .|  ..|
prnahcclqfdklsv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 839-954 3.6e-34 112.7 In-house 36-149 (515) alignment
Range on Protein: 839-954
Range on HMM: 36-149/515.0
IIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
 .  .| |   ||.|||  || .|..|      |  . .|.||||| .. . . .|||||| | .. |||||..||..  |.|||.|||| |.|| .|||
tvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

NGRAESDHFGSFTVTL
.  ..| .|||. | |
dkpgdsvkfGsikvel

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 839-955 2.3e-28 94.3 In-house 41-154 (325) alignment
Range on Protein: 839-955
Range on HMM: 41-154/325.0
IIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQY
 .    || | |||||.  .| .|..|    | |  . .||||||.  .   . |.|.| |. .|. |.|||.  |.    |.|.|.|  .. | .| .|
kvamkpenkaknrfknvvaldksrvvle..tkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavy

WPNGRAESDHFGSFTVTLT
||.  ..| .||.. | | 
wpkemgksktfGglevklr

0037934 (Phosphotyrosine protein) phosphatases II 839-957 2.5e-28 94.7 In-house 3-110 (243) alignment
Range on Protein: 839-957
Range on HMM: 3-110/243.0
IIGYNEENTAFNRFKNITVYDDNRIILapnrklDMcqREYINASYIDGYsssNKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCE
 |.  .||   ||...|  ||..|..|      .     ||||..|...   ...||.|||...|. |    |||..|...  .|||.|.|.| .. ||.
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPngraESDHFGSFTVTLTNE
||||    .. ..| |||||..|
qywp....gevtygdftvtllse

subfamily_PTPN12_pd Subfamily PTPN12 840-958 1.3e-31 104.6 In-house 34-150 (290) alignment
Range on Protein: 840-958
Range on HMM: 34-150/290.0
IGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
 | .|||.. ||.|.|  || .|. |  ... .  . .||||..| | ... ..||.|||. ||| ||||.||. .   .||. .. |  | |||.|||.
agekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

GRAESDHFGSFTVTLTNEQ
   |. .||.|.|||..|.
egeeelefgefevtleeek

subfamily_ptpA1_pd Subfamily ptpA1 840-940 1.5e-19 65.0 In-house 41-138 (418) alignment
Range on Protein: 840-940
Range on HMM: 41-138/418.0
IGYNEENTAFNRFKNITVYDDNRIILapNRKLDMCQREYINASYIDGYsSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
 | .. ||. ||. ||   .  |. |  ..  |    .|||| ||||    ..||..|||. .|. ||||..|...   |||..   |  . ||..|||.
egdkkhntsknrytnilpvnhtrvql..kkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

G
 
q

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 841-957 5.8e-33 109.1 In-house 4-115 (250) alignment
Range on Protein: 841-957
Range on HMM: 4-115/250.0
GYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPNG
. . .|   ||. .|  .|  |..| ...  . .  .|||||...||. .. |||.|||...|..||||....||  .|||.|||||  |  ..||||  
akkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

RaeSDHFGSFTVTLTNE
.  ....|. ||.| ..
k..aekyGdvtvsllsk

subfamily_PTPN23_pd Subfamily PTPN23 841-957 1.4e-28 94.5 In-house 38-149 (288) alignment
Range on Protein: 841-957
Range on HMM: 38-149/288.0
GYNEENTAFNRFKNITVYDDNRIILApnrkldMCQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
   . ..  ||...|  || ||. |         . .|||||.. . |. . .|||.|.|...|| |||......|   |||... .|  | |...|||.
aiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

GRAESDHFGSFTVTLTNE
 . |. .|| ..||| ..
dkgetvkfgdlsvtlksv

0042113 (Phosphotyrosine protein) phosphatases II 842-957 3.3e-31 104.0 In-house 5-116 (245) alignment
Range on Protein: 842-957
Range on HMM: 5-116/245.0
YNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgr
. .||  .||...|  ||..|..| |      .   ||||||.|||  ..||||.|||...|. ||||..|...  .|||.|.. |  . ||.||||.  
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

AESDHFGSFTVTLTNE
 ||  .| |||||..|
gesltygdftvtllse

subfamily_PTPN1_pd Subfamily PTPN1 842-944 1.8e-22 74.4 In-house 28-125 (290) alignment
Range on Protein: 842-944
Range on HMM: 28-125/290.0
YNEENTAFNRFKNITVYDDNRIILAPNRKldmcqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
 ..|| . ||..... ||  ||.|  . .      .||||| ..      ..| .|||. .|   ||...|..|  ..||. .. |  . || ||||.| 
klpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

A-ES
  ..
eeke

subfamily_egg_pd Subfamily egg 842-953 1e-20 68.6 In-house 36-145 (307) alignment
Range on Protein: 842-953
Range on HMM: 36-145/307.0
YNEENTAFNRFKNITVYDDNRIILapNRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYWPNGR
....|    | | .   |  |. |  . .  .   ..| | ...|    |.|| .| |.| |  ||||...||.   |||.|  ||    .|| |||.  
asdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

AESDHF--GSFTVT
..|  .  ||. ..
sdslvtvpGslrie

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 842-956 7.6e-09 29.5 In-house 92-197 (244) alignment
Range on Protein: 842-956
Range on HMM: 92-197/244.0
YNEENTAFNRFKNITVYDDNRIILApnrKLDMCqREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNGR
.| .|.  ||      .| ||. |.   |  |    |||||..     . ..| .| |.  | .|||...  |. | ...|     |.  . ..|||.  
fnpnnswknregaglpfdfnrvpls...kgsmg.ntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpdse

AESDHFGSFTVTLTN
    .    |||||.
plewyeeditvtltd

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 843-956 3.1e-18 60.8 In-house 26-140 (285) alignment
Range on Protein: 843-956
Range on HMM: 26-140/285.0
NEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
|   ||..   ..  | | | |      |   .|.|| ||..       . .|..|||. .|| |||..|.|||   ..|.  | ||   ||  |.|.  
nctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

AESDHFGSFTVTLTN
 |  .|| . .|||.
gevvkfgkyeitlte

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 845-956 7.5e-29 96.0 In-house 60-163 (319) alignment
Range on Protein: 845-956
Range on HMM: 60-163/319.0
ENTAFNRFKNITVYDDNRIILAPNRKLDMcqREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAES
.|   ||. ||  .| |.. | .    ..   .|||||...|| . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   . 
qnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

DHFGSFTVTLTN
.  .   |.. .
eerfkvkvdsve

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 845-956 1.2e-28 95.4 In-house 24-127 (284) alignment
Range on Protein: 845-956
Range on HMM: 24-127/284.0
ENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAES
.|   ||. .|  .| |.. | .    .    .|||||.| || . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   . 
qnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

DHFGSFTVTLTN
.. .   |.. .
eerfkvkvdsve

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 845-944 1e-27 91.8 In-house 19-117 (270) alignment
Range on Protein: 845-944
Range on HMM: 19-117/270.0
ENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE
 ....||...|      |..|.. ..    . .|||| |. |.... .|.||..||.. || .|||.||.||  .|||.|.|.|  ..|||.|||. . |
rgkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

S
.
k

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 845-956 9.3e-27 88.8 In-house 2-109 (237) alignment
Range on Protein: 845-956
Range on HMM: 2-109/237.0
ENTAFNRFKNITVYDDNRIILAPNRKLdmcqREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaE
|| . ||. ||..|| .|..|  .        .||||.|..|.  . .|.||.|||.. .  |||...||||   |||.| | || . || .|||.   .
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

SDHFGSFTVTLTN
   .| .||.|. 
paaygvltvslkk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 845-944 1.2e-20 68.5 In-house 46-157 (350) alignment
Range on Protein: 845-944
Range on HMM: 46-157/350.0
ENTAFNRFKNITVYDDNRIILA-----P-NRKLDMCQREYINASYIDGY------SSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
|  | ||.|||  |. .|..|      .  .|  .   .||||.|.          .. |.|| |.|...|. ||...| . |   |...|.. |    |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CEQYWPNGRAES
|..||..|  . 
cyrYWqegsydd

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 845-955 4.7e-20 66.8 In-house 40-146 (307) alignment
Range on Protein: 845-955
Range on HMM: 40-146/307.0
ENTAFNRFKNITVYDDNRIILapnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
 ||  ||.... . | .||..    |.|    .|| | |.      .|||..|||...|  .|| .. |||  |..|. .. | .| |||||||  . . 
antdknryqdvkcqdkgrivv....kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

DHFGSFTVTLT
  ||. . |..
lvfgeapntis

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 845-943 1.6e-11 38.2 In-house 47-159 (349) alignment
Range on Protein: 845-943
Range on HMM: 47-159/349.0
ENTAFNRFKNITVYDDNRIILAPNRK-----------LDMCQ-REYINASYID--GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTK
|  | ||.|.|  |.  |..|    |            | ..  .|||| |.    .|  .|.|| | |.  |. ||...|  ..   .. ... || . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

SKCEQYWPNGRAE
 ||..|| ..  .
ekcdiywqelsys

subfamily_eak_pd Subfamily eak 845-953 2.7e-07 24.3 In-house 51-155 (332) alignment
Range on Protein: 845-953
Range on HMM: 51-155/332.0
ENTAFNrFKNITVYDDNRIILAPNRKldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
|.   |   .|  || . . |.. ..    .  ||||| ..     .|.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|.   | 
eavnrn.vvkivpydrylvrltssql...nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

DHFGSFTVT
 .|| . |.
lkfGildve

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 846-955 3.5e-25 83.4 In-house 38-143 (287) alignment
Range on Protein: 846-955
Range on HMM: 38-143/287.0
NTAFNRFKNITVYDDNRIILAPNRKLDMcqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESD
..  ||. ..  .||.|..|. . .|     .|||| |. .|   ..|||.|||.  |. ||||......  |....|   | .. || .|||.      
avkknryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

HFGSFTVTLT
  | ..|.| 
rvGGysvvll

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 846-942 1.6e-24 81.4 In-house 8-103 (239) alignment
Range on Protein: 846-942
Range on HMM: 8-103/239.0
NTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
| | ||. ||  || .|..|   .  .  . .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .
nkaknryanivtydhsrvvle..klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 846-942 1.7e-24 81.3 In-house 7-102 (239) alignment
Range on Protein: 846-942
Range on HMM: 7-102/239.0
NTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
| | ||. ||  || .|..|   .  .  . .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .
nkaknryanivtydhsrvvle..klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

0041856 (Phosphotyrosine protein) phosphatases II 846-940 2.7e-17 58.4 In-house 1-74 (182) alignment
Range on Protein: 846-940
Range on HMM: 1-74/182.0
NTAFNRFKNITVYDDNRiilapnrkldmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPNG
|   ||...|  || .|               ||||....|.  ...||| |||...|. ||.|......  .||..|         .|.|||. 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 846-941 6.8e-17 56.1 In-house 48-138 (305) alignment
Range on Protein: 846-941
Range on HMM: 48-138/305.0
NTAFNRFKNITVYDDNRIILAPNrkldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
..  ||.|..   |.||. | .         ||| | |.   . ...|| .| |..||  ||| . .|.|  .| |. ||.|    || .|..   
eagknrykdvgcldnnrvklegp.....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 846-947 1.9e-14 48.0 In-house 55-152 (305) alignment
Range on Protein: 846-947
Range on HMM: 55-152/305.0
NTAFNRFKNITVYDDNRIILAPNRkldmcQREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
. . ||.... . | . . |.          .|| | |.       ..||..|||. .|. .|| .. |.|   |||. .  |  | || ||||  . | 
aitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

DHF
 ..
lel

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 846-933 3.8e-10 33.8 In-house 34-118 (332) alignment
Range on Protein: 846-933
Range on HMM: 34-118/332.0
NTAFNRFKNITVYDDNRIILAPNRKLDmcqrEYINASYIDGYSSSNKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
|  .||   . ..| .|. |||.   |    .. |||..||||  . .| .| |.. .|   |||.. . ||  |... .. |  | |.
nmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

Y_phosphatase Protein-tyrosine phosphatase 847-956 5.1e-35 116.4 Pfam-A 2-108 (235) alignment
Range on Protein: 847-956
Range on HMM: 2-108/235.0
TAFNRFKNITVYDDNRIILapnrkL------DmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
   ||.|.|..||..|. |            |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. 
kkknRykdilpydktrvkl.....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

RAESDHFGSFTVTLT-N
. || ..|...|.|. .
eeesltygdikvelkek

Y_phosphatase Protein-tyrosine phosphatase 847-956 5.1e-35 116.4 In-house 2-108 (235) alignment
Range on Protein: 847-956
Range on HMM: 2-108/235.0
TAFNRFKNITVYDDNRIILapnrkL------DmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
   ||.|.|..||..|. |            |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. 
kkknRykdilpydktrvkl.....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

RAESDHFGSFTVTLT-N
. || ..|...|.|. .
eeesltygdikvelkek

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 848-954 1.1e-28 95.2 In-house 30-138 (274) alignment
Range on Protein: 848-954
Range on HMM: 30-138/274.0
AFNRFKNITVYDDNRIILAPNRKLDmCQREYINASYIDGYSSSN-KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE--S
  ||.|.|   .  |..| ..   |  . .|||| || ||.  .  ..| |||. .|. ||||.|.||.   |||.|.|||  ..||..|.|. .    |
tknryktilPnensrvllesessed.edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

DHFGSFTVTL
...| . .. 
erygdveikv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 848-953 2.2e-23 77.6 In-house 35-138 (297) alignment
Range on Protein: 848-953
Range on HMM: 35-138/297.0
AFNRFKNITVYDDNRIILapnrKLDMCQREYINASYIDG--YSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESD
  ||...|  .||.|. |    .  . .|.|||| |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||.   |  
rknryrdilatddtrvkl....lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

HFGSFTVT
. |.. | 
kagdvvve

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 849-937 3e-09 31.0 In-house 46-128 (312) alignment
Range on Protein: 849-937
Range on HMM: 46-128/312.0
FNRFKNITVYDDNRIILAPNRKLdmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
.||. || ..|  |. || . ..      || | ..   .  ..|...|||...| . ||.|      .||.... . | .  || .| 
lnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 849-922 7.8e-06 19.7 In-house 50-114 (303) alignment
Range on Protein: 849-922
Range on HMM: 50-114/303.0
FNRFKNITVYDDNRIilapnrklDMCQREYINASYIDgYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMV
 ||| .. . |  ..         ...  || |||..   ||.| | .| |. .|  |||..| ..|   ....
knrfvdvicldhskv........klsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 855-955 1.3e-08 29.4 In-house 27-135 (290) alignment
Range on Protein: 855-955
Range on HMM: 27-135/290.0
ITVYDDNRIILAPNRKLdmCQREYINASYIDgYSSSNKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNGRAE
...  ..|..|    |    . .|| |...  ...  ..|..| | .|.       . .|| .. |||  ..||. . .| ..      |..| |.   |
vpLveatrvvLkgygkr..fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

SDHFGSFTVTLT
.  |. .||  .
elkfkgltvkCk

0044763 (Phosphotyrosine protein) phosphatases II 870-940 4.7e-09 31.6 In-house 12-73 (178) alignment
Range on Protein: 870-940
Range on HMM: 12-73/178.0
KLDMCQREYINASYIDGYsssnKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
  ...  .|||||.|...     ...|..|     .|...|.....  .||..|. .|. . || .||| .
leglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpee

subfamily_CG42327_pd Subfamily CG42327 871-956 3.6e-17 57.0 In-house 51-139 (319) alignment
Range on Protein: 871-956
Range on HMM: 51-139/319.0
LDMCQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA--ESDHFGSFTVTLTN
 |  . ||..|||. || .  | .||.| .....  ||||..|. .   || .|.| |    .| .|.|   .  . . .| . ||| .
gdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkg

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 874-957 2.6e-13 44.4 In-house 73-156 (301) alignment
Range on Protein: 874-957
Range on HMM: 73-156/301.0
CQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
 .|  | | .|.    ...|||.|||.|.|  ||| .. | .   |||...  | ...|||.| |   .|. . | |.....|.
GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknk

0043147 (Phosphotyrosine protein) phosphatases II 876-926 7.5e-12 40.8 In-house 5-55 (172) alignment
Range on Protein: 876-926
Range on HMM: 5-55/172.0
REYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLK
. ||||||.|.|   ..||| |||.  || ||||......   ||..|.| 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltell

0051429 (Phosphotyrosine protein) phosphatases II 877-954 9.1e-16 53.8 In-house 5-94 (272) alignment
Range on Protein: 877-954
Range on HMM: 5-94/272.0
EYINASYIDGYSS---SNKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NGRAESDHFGSFTVTL
 ||||....|| .    .....|.||.. |  ||||| ....  .||..... |  . ||..|||          .  |..  .| ..|||
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtl

0036282 (Phosphotyrosine protein) phosphatases II 877-943 2.1e-14 49.1 In-house 3-64 (174) alignment
Range on Protein: 877-943
Range on HMM: 3-64/174.0
EYINASYIDGYSSSNKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE
 |||||..|..  ....||.|||..     ||.......  ..||....||  . || .|||  |  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelred

0046846 (Phosphotyrosine protein) phosphatases II 877-941 2.5e-12 42.4 In-house 13-73 (176) alignment
Range on Protein: 877-941
Range on HMM: 13-73/176.0
EYINASYIDGYsssnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
 ||||..|.|.    ..|| |||. .|| ||........   .|..|...|  . || .|||  .
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpele

0051082 (Phosphotyrosine protein) phosphatases II 877-939 2.4e-09 32.5 In-house 4-55 (151) alignment
Range on Protein: 877-939
Range on HMM: 4-55/151.0
EYINASYIDGYsssnkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPN
 |||.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|.
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpe

0049260 (Phosphotyrosine protein) phosphatases II 883-937 5.4e-11 37.9 In-house 1-55 (152) alignment
Range on Protein: 883-937
Range on HMM: 1-55/152.0
YIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
.||||  ...||| |||.  || ||||.... .   |||.|.| | .| |||||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 885-953 4.8e-12 39.9 In-house 230-294 (440) alignment
Range on Protein: 885-953
Range on HMM: 230-294/440.0
DGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNgRAESDHFGSFTVT
.|||  | |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   . |  || ||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpv.ntrsvtfgpftvg

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 890-954 5.5e-10 33.7 In-house 4-68 (199) alignment
Range on Protein: 890-954
Range on HMM: 4-68/199.0
SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTL
  ..||.| |...|. |||...|.     |||| . .   ..    |||   . . ..||..|| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 891-954 6.5e-10 33.5 In-house 4-67 (198) alignment
Range on Protein: 891-954
Range on HMM: 4-67/198.0
NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTL
 ..||.| |...|| |||...|.     |||| . .   ..    |||   . . ..||..|| 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt

subfamily_hpo-7_pd Subfamily hpo-7 901-957 1.1e-06 22.7 In-house 44-100 (263) alignment
Range on Protein: 901-957
Range on HMM: 44-100/263.0
KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
 .|.  |.. | | |.  .||... .|  . ||..|.|  . |   .   .|. |. 
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 903-956 3e-07 24.8 In-house 40-93 (255) alignment
Range on Protein: 903-956
Range on HMM: 40-93/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTN
|.  |.. | | |.  .||.....| .. ||..|.|  . |   .   .|| |.
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk