Gene PTPRD-57 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP114_AA protein Get Run
AqueP114_AA_890-1116 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 119-193 1.4e-12 40.8 Pfam-A 2-79 (85) alignment
Range on Protein: 119-193
Range on HMM: 2-79/85.0
APSSLTEVSQTATTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLRELTTYSITVRAYQQL
||. |.  ..|.|..|.||.. .  ... .|| | . .....   ....|..... . ||.||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 451-539 9.2e-10 31.7 Pfam-A 2-81 (85) alignment
Range on Protein: 451-539
Range on HMM: 2-81/85.0
APSPPTEVNKTATTITVNWTALD--SSDADGYVVNVTSDTDTVqtvqlssVNETVSVDPHqsttTYSYTLIGLYSGMNYTIIVRAGNVLGG
||. ..  . |.|..|..|.. .  ... .|| | . .....        .  ...|...    |.|.|| ||  |..|.. |.| |  |.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprt....ttsvtltgLkpgteYefrVqavngage

fn3 Fibronectin type III domain 558-637 9.8e-12 38.0 Pfam-A 3-85 (85) alignment
Range on Protein: 558-637
Range on HMM: 3-85/85.0
PSSIQVLPVNSTANNLTWNEVNcsERNGLITGYTVIISNS-----SITYNLTSTERYIILNDLVFGSEYNISVAAVNSVGRGPFS
|. ..| .|.||  .|.|.. .  ...| ||||.|  ...     . ......|..  .|..|  |.||...|.||| .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 654-747 3.3e-06 20.3 Pfam-A 8-85 (85) alignment
Range on Protein: 654-747
Range on HMM: 8-85/85.0
VSSImDTTLAVISWSVPSyiPSDYPIITYEIGYHILESGNcsvvddddidnqrL----QfinsTNGNTFTSRITDLNAMSCYIFGVRAYTDNGYGEWT
||..  .| ...||| |.  . . ||  ||. |   ..|.                  .    . ..| .  .|.|.. . | | |.|....|.|...
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeft....vprtttsvtltgLkpgteYefrVqavngagegpeS

0039614 (Phosphotyrosine protein) phosphatases II 879-1117 2.4e-50 167.1 In-house 5-291 (297) alignment
Range on Protein: 879-1117
Range on HMM: 5-291/297.0
DPLIPKTCPVSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDLRS--------------------------------------------TGYRE-KRAFI
 . . ...|...| |  ..  .. . .  . .... |.   . .|                                            .||.  .|.||
rdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

IAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC---CFPYW--LSGrKYDEYGLEVTNEINSNGYTERMFKVSSDKEAisRNVLQLQVADWPQDGVVRE
..| |...|| |||.|. ...|..||||. ....   |..||   .| .|...  ......  .||| | ..|. ..|   | | ..|. .|| .||   
atqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvpps

PRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
....|.... | .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..|. 
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0045450 (Phosphotyrosine protein) phosphatases II 883-1115 2e-50 167.6 In-house 4-304 (307) alignment
Range on Protein: 883-1115
Range on HMM: 4-304/307.0
PKTCPVSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDLRS--------------------------------------------------------TGY
|  ..... .|  .|.  . | .. . .... |.   .  .                                                         ||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVSSD-KEAISRNVLQLQVA
. ||.||..|.|...|| |||.|. ...|..||||......    |..|| . .    |...  ....|   .||| | ..|.   ..  || | ...  
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

DWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
.|| .||   . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|... ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l

0051299 (Phosphotyrosine protein) phosphatases II 886-1115 6.1e-53 175.5 In-house 3-286 (288) alignment
Range on Protein: 886-1115
Range on HMM: 3-286/288.0
CPVSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDLRS---------------------------------------------TGYREKRAFIIAQSPME
 ..|...|  .|  .. . .. . .... |.     ..                                             .||. ||.||..| |..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

NTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSgR---KYDEYGLEVTNEINSNGYTERMFKVSSD----KEAISRNVLQLQVADWPQDGVVREP
||| |||.|. ...|. ||||.....     |..|| . .   .|...  . ..|   ..|| | ..|.      ..  ||.| .... .|| .||   |
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

RTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|... .||
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 888-1115 3.1e-48 160.0 In-house 2-277 (278) alignment
Range on Protein: 888-1115
Range on HMM: 2-277/278.0
VSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDlR-S--------------------------------------------TGYREKRAFIIAQSPMENT
.|..||  ... .. . .... .... |.. .                                                 .||. .|.||..| |...|
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLsG--RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVI
| |||.|. ...|. ||||.....     |..||  |   .|...  ....|.  ..|| | ..|.  ..  || |....  .|| .||   . ..|. .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

DDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 .|.....   .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|... .||
kavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 893-1120 3.7e-54 179.5 In-house 31-304 (308) alignment
Range on Protein: 893-1120
Range on HMM: 31-304/308.0
LGTHVASyhSDTNAAFNQQYQGLYTGDDLRS----------------------------------------TGY--REKRAFIIAQSPMENTVRDFWKMI
|  .. .   . .  ...... |.   .|..                                        .||  . .|.||..|.|..||| |||.|.
llkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

LDYKVSAIVMLCGEEDC----CFPYWLSG-----RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIH
 ...|. ||||. ...     |..|| .      ..|. . .....| . ..|| | ....  ..  || | ...  .|| .||  .|. .|. .. | .
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

RQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSM
..   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|... .||.   .
sl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

0036941 (Phosphotyrosine protein) phosphatases II 900-1117 1.5e-52 174.1 In-house 7-279 (297) alignment
Range on Protein: 900-1117
Range on HMM: 7-279/297.0
YHSDTNAAFNQQYQGLYTGDDLRS-----------------------------------------TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAI
 ... .| . .... |.    | |                                         .||. ||.||..| |..||| |||.|.....|. |
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLCGEEDC----CFPYWL----SGRKYDEYGLEVTNEIN--SNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKI-G
|||. ...     |..||     .  .|... ......    ...|| | ..|.  ..  || | .... .|| .||   |...|. |. | ...... .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

GGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|... ..|. 
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

0051429 (Phosphotyrosine protein) phosphatases II 907-1115 3.2e-30 101.1 In-house 6-225 (272) alignment
Range on Protein: 907-1115
Range on HMM: 6-225/272.0
AFNQQYQGLYtgddlrsTGYREKRAFIIAQSPMENTVRDFWKMiLDYKVSAIVMLCGEE----DCCFPYWL--------------SGRKYDEYGLEVTNE
..|  . | |       ...  ..... .. |...|..|||..  ......||.|..||    . |..||                   |  . . .. |
yiNardvggy.......grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

INSNGYTERMFKVSSD-KEAISRNVLQLQVADWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD-----
.. . |. |.. ..   .   .| |..|.  ||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||     
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
   .... . .|.  |||| | |||  .|...  .|
nlyleeaveelraqrpgavqteeqylflyeallell

0040439 (Phosphotyrosine protein) phosphatases II 923-1115 1.1e-46 154.9 In-house 47-246 (249) alignment
Range on Protein: 923-1115
Range on HMM: 47-246/249.0
STGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
 .||. ||.||..| |...|| |||.|. ......||||. .. .    |..|| .    .|...  ...... ...|| |.....  ..  || ||..|
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VADWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. ||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . ||| . |. ||.... | .|. .||||...|||  .|... ..|
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell





subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 923-1111 8.2e-40 131.5 In-house 68-262 (283) alignment
Range on Protein: 923-1111
Range on HMM: 68-262/283.0
STGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRN-VLQL
|  |.... .||||||...||.|||||. | |..|||||     ...  |  || .    .| |. . . .|  || .. . . .  .  | |   .   
sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahy

QVADWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|| ||    .  .. ...     .. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
qvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 923-1004 3.1e-08 27.7 In-house 101-181 (350) alignment
Range on Protein: 923-1004
Range on HMM: 101-181/350.0
STGYrekrAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGrKYDEYGLEVTNEINSNGYTERMFKVSSD
 ...     .| .|.|. .|| ||.|.||  ||  |..|  . .     |  ||  | .||.. . ...  .. . .. . . |.|
npdf....kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg.sydditvklaskwenimgindsslysad

0046845 (Phosphotyrosine protein) phosphatases II 924-1119 6.1e-52 172.1 In-house 66-278 (284) alignment
Range on Protein: 924-1119
Range on HMM: 66-278/284.0
TGY-----REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVSSDK-EAISR
.||     . |..||..| |..||| |||.|.....|. ||||.....     |..|| .     .|...  ....| . ..|| |.....  . .  ||
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

NVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTS
 | .... .|| .||  .|. .|. ...| . ...  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf

IYDVIDMYLQMNS
.|... .||..  
vyealleylklkl

0047943 (Phosphotyrosine protein) phosphatases II 924-1115 2e-51 170.5 In-house 71-272 (273) alignment
Range on Protein: 924-1115
Range on HMM: 71-272/273.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR-----KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQ
.||. ||.||..| |..||| |||.|. ...|. ||||. ...     |..|| .       .|...  ....| . ..|| | ..... .   || | .
dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvth

LQVADWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
... .|| .||   .  .|. |..| . .... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... .
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

YL
||
yl

0040438 (Phosphotyrosine protein) phosphatases II 924-1119 5.1e-50 165.9 In-house 80-280 (317) alignment
Range on Protein: 924-1119
Range on HMM: 80-280/317.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSgR---KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
.|...||.||..|.|..||| |||.|. ...|. ||||. .|..    |..|| . .   .|...  ....|.  .|.| | ..|. ...  || | ...
dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VADWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  .|| .||   |...|. .. | . ..  . ||||.||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. .||
ytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

QMNS
. . 
krkl

Y_phosphatase Protein-tyrosine phosphatase 924-1111 1.1e-49 164.3 Pfam-A 36-233 (235) alignment
Range on Protein: 924-1111
Range on HMM: 36-233/235.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWL----SGRKYDEYGLEVT-NEI-NSNGYTERMFKVSSDKEAI-SRNV
.||.||..||..| |...|. |||.|....||..||||. .|.     | .||        .|... .|.. .|  ....|| | ......||   .| |
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

LQLQVADWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||.. .||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 924-1111 1.1e-49 164.3 In-house 36-233 (235) alignment
Range on Protein: 924-1111
Range on HMM: 36-233/235.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWL----SGRKYDEYGLEVT-NEI-NSNGYTERMFKVSSDKEAI-SRNV
.||.||..||..| |...|. |||.|....||..||||. .|.     | .||        .|... .|.. .|  ....|| | ......||   .| |
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

LQLQVADWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||.. .||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

0042113 (Phosphotyrosine protein) phosphatases II 924-1115 2.3e-44 147.0 In-house 46-243 (245) alignment
Range on Protein: 924-1115
Range on HMM: 46-243/245.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSgR---KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
.||| .. ||..| |...|| |||.|. ......||||. ||.     |..|| . .   .|...  ....| . ..|| | ..|. ...  ||.|....
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  .|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  .|... ..|
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPRA_pd Subfamily PTPRA 924-1119 6e-44 145.3 In-house 95-300 (330) alignment
Range on Protein: 924-1119
Range on HMM: 95-300/330.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVS----SDKEAISRNVL
 ||.||  || || | |.|| |||.|| ..| ..||||      .|. |  || .     | .  .|| .|  .. || | | |     . .|  || | 
dGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvr

QLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|.    ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  
qfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

Y-LQMNS
| |  ..
yylygdt

subfamily_Ptp69D_pd Subfamily Ptp69D 924-1114 1.2e-42 141.1 In-house 85-285 (307) alignment
Range on Protein: 924-1114
Range on HMM: 85-285/307.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWL--SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAI-----SRNV
 ||.||. ||.|| |.|.|. |||.|| . .|  ||||  ...     |  ||      .|..   .. .| . . |..| ..||  ||       ||.|
kgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkv

LQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.| .   |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  . 
vqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyrall

MY
 |
dy

subfamily_PTPRK_pd Subfamily PTPRK 924-1111 3.6e-41 136.0 In-house 80-273 (314) alignment
Range on Protein: 924-1111
Range on HMM: 80-273/314.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG-EED---CCFPYWL-SGRKYDEYGLEVTNEINSNGYTERMFKVSS--DKEAISRNVLQLQ
 .|.  .|||..| |...||.|||....|.. ..||||    |     |  ||   ...|..  .|. .    . .  |.|.|.    .    | | |.|
dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfq

VADWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
   ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
flgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 924-1110 2.8e-38 127.0 In-house 98-286 (319) alignment
Range on Protein: 924-1110
Range on HMM: 98-286/319.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCgeEDCCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSS-DKEAISRNVLQLQVADW
|||. |  .| || |..||. |||.|| .|..|.||.|   .| |  ||      |.... ..|.   ... |. | ...|   ||   |.. |     |
tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGw

PQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
pdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 924-1110 4.4e-38 126.4 In-house 62-250 (284) alignment
Range on Protein: 924-1110
Range on HMM: 62-250/284.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCgeEDCCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSS-DKEAISRNVLQLQVADW
|||. |  .| .| |..||. |||.|| .|..|.||.|   .| |  ||      |.... ..|.   .|. |. | ...|   ||   |.. |     |
tGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgw

PQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
pdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 924-1111 9.3e-38 124.9 In-house 86-275 (315) alignment
Range on Protein: 924-1111
Range on HMM: 86-275/315.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGR-KYDEYGLEVTNEINSNGYTERMFKVSSDKEaIsRNVLQLQVA
 ||  || .| ||.|  ..|.|||... ..... ||||     ||.  .  ||   .  | .. .   .|   . || | . | .... | |.|.||...
dGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdn.i.revvqlhyt

DWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||..
swpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_PTPRG_pd Subfamily PTPRG 924-1112 1.3e-36 120.9 In-house 85-284 (563) alignment
Range on Protein: 924-1112
Range on HMM: 85-284/563.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSS-----DKE-AISRN
 ||. ..|||..| |...|. |||.|| . .|. |||.      .   |. || .    .|..  .  ..|     ||.| ...        |.    ..
dGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdtekl

VLQLQVADWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| | . ..||. ||   .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|..
vrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

D
 
l

subfamily_PTPN9_pd Subfamily PTPN9 924-1114 2.5e-31 103.8 In-house 79-289 (297) alignment
Range on Protein: 924-1114
Range on HMM: 79-289/297.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--E--EDCCFPYWL----SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQL
 ||..|.||| .| |...||.|||.|. . .|  |||     |     |  ||     |  .. .. ... .  ... |..|.....  |.  ||.|   
dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthf

QVADWPQDGVVREPRTVLQVIDDVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
|.  ||  || ..  ..|.|.. | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | ||
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq

YTSIYDVIDMY
|.  |  .  |
yefcylavley

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 924-1114 5.2e-29 96.0 In-house 85-278 (439) alignment
Range on Protein: 924-1114
Range on HMM: 85-278/439.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDCcFPYWLSGRK--YDEYGLEVTNEINSNGYTERMFKVSSDK--EAISRNVLQLQVAD
 || ... .| .| | ..|. |||..... |.. ||||.   .  . || |  .  | .  . |  .|.   |. | |||  ..      | |||..   
kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves.ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyia

WPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .   
wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 924-1111 8.4e-26 85.3 In-house 230-434 (440) alignment
Range on Protein: 924-1111
Range on HMM: 230-434/440.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED-CCFPYWLSGRKYDEYGL---EVTNEINSNGYTERMFKVSSdKEAIsRNVLQLQVAD
 ||  | ||| .| |.. || |||... ||..|.|.||   .|  |  ||    .   .|          | |    | ...   || .  .. |..|  
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky.keev.heirqfevqt

WP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | || .|
wptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdy

TSIYDVI
   | ..
llcykll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 924-1119 6.4e-25 82.5 In-house 74-281 (287) alignment
Range on Protein: 924-1119
Range on HMM: 74-281/287.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE-ED---CCFPYWLSGRKYDE---YGLE-VTNEINSNGYTERMFKVSSDKEAISRNVLQL
..|... ||| ||.|.  ||||||...|. ........  | |.    |. ||   ..      | .  .  .| .  |. | ...   .   .| | ||
asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkql

QVADWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. .
dllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

DMYLQMNS
  | . | 
vtyyktnp

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 925-1123 3e-106 349.5 In-house 80-301 (301) alignment
Range on Protein: 925-1123
Range on HMM: 80-301/301.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGRKYDEYGLEVTNEINS---------------------NGYTERMF
||.||..||.||.||..|..|||..|...|...|||.......    |. || .... .|.  ..|.....                     |||.||.|
gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkf

KVSSDKeaISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
||.|||   |..||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
kvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

TLEQYTSIYDVIDMYLQMNSMYGN
|||||||||||||||||.||.|.|
TLeqytsiydvidmylqlnstyan

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 925-1118 9.7e-79 259.7 In-house 84-286 (305) alignment
Range on Protein: 925-1118
Range on HMM: 84-286/305.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGR----KYDEYGLEVTNEINSNGYTERMFKVSS-DKEAISRNVLQL
||..| ..|.||.|..|||.|||..|...||| ||||.    |..|.|  ||        ...|. .|...| . ..|.|| .|.|  |..  ||.|||.
gykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqy

QVADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. |||..||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| ..
qltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

QMN
.  
tcg

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 925-1124 1.4e-63 209.5 In-house 81-287 (287) alignment
Range on Protein: 925-1124
Range on HMM: 81-287/287.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSSDK-EAISRNVLQLQV
||.||.|||||.||| ||.|.|||.| | .|.||||||     .|. |. || ...   . || .|..||  ..||.|| ..|  .. ..  ..| | |.
gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqi

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
..|.. | | ||.|.| ||.. .. |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||. 
tnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

NSMYGNF
 ..| .|
fetysdf

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 925-1120 1.9e-62 205.8 In-house 86-288 (290) alignment
Range on Protein: 925-1120
Range on HMM: 86-288/290.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVSSDKE-AISRNVLQLQV
||.||...|..|.|..||..||||.| . ||..||||.     ... |  || .   ..|.|. ....|| . |.|.|| ..| .... . ...| |.|.
gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqi

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
  |...| | .| |.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....  ||. 
tnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

NSM
 . 
fet

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 925-1119 7.9e-53 174.6 In-house 94-294 (298) alignment
Range on Protein: 925-1119
Range on HMM: 94-294/298.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
.|... |||..| |...|| |||.|. ......||||   |.     .  || .   ..|.|  ... .. .   .. | .|||. ||. .|.| ||.. 
aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhft

DWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 ||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|.  
sWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

S
.
n

subfamily_PTPRD_pd Subfamily PTPRD 925-1118 1.1e-51 171.2 In-house 86-284 (564) alignment
Range on Protein: 925-1118
Range on HMM: 86-284/564.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
|||...|.| .| |...|..|||.|. ....| ||||   |    . |  || .    .|.|.  ....| . . |. | ||..  |.  ||.| | .  
gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFt

DWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|.. 
sWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg





subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 925-1121 1.1e-50 167.1 In-house 47-248 (250) alignment
Range on Protein: 925-1121
Range on HMM: 47-248/250.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG---EEDCCFPYWL--SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVAD
||.|..|||..|.|...|. |||.|.|..|...||||     .|  .  ||     .|| .  ... .. .   || | .|.|. |.| .| | ||.   
gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvv

WPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNS
||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  .|.  .
WPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

MY
 |
dy

DSPc_SM00195 925-1115 1.8e-49 163.8 In-house 64-262 (263) alignment
Range on Protein: 925-1115
Range on HMM: 64-262/263.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSG----RKYDEYGLEVTNEINSN-GYTERMFKVSSDKEAISRNVLQL
|...|...|..| |...||.|||.|... ||. ||||. ||..    |  || .      ..... ........ .  .. | .... ...  .|.| |.
gankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

QVADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. .||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
qyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi





PTPc_SM00194 925-1115 1.8e-49 163.8 In-house 64-262 (263) alignment
Range on Protein: 925-1115
Range on HMM: 64-262/263.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSG----RKYDEYGLEVTNEINSN-GYTERMFKVSSDKEAISRNVLQL
|...|...|..| |...||.|||.|... ||. ||||. ||..    |  || .      ..... ........ .  .. | .... ...  .|.| |.
gankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

QVADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. .||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
qyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi





subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 925-1121 5.7e-49 161.9 In-house 84-286 (318) alignment
Range on Protein: 925-1121
Range on HMM: 84-286/318.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
|||.|.|.| ||.|. .|..|||.|. . . . ||||  ||.     .  || |   |.|..   |...|.... |. | |||. ..|  ||.| | ...
GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhyt

DWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .|.  
sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

SMY
 ..
dte

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 925-1118 4.5e-47 155.7 In-house 86-286 (319) alignment
Range on Protein: 925-1118
Range on HMM: 86-286/319.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSSDKEAI-SRNVLQLQV
||.|...|| .|.|.|||. |||.|. ....| .|||..  .     .  || .    .| .. ... .| . ..|  | .|.   .. . .|.| . | 
gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqy

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 .||...| .. ...|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  ....
teWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

N
 
g

0045098 (Phosphotyrosine protein) phosphatases II 925-1117 1.7e-42 141.2 In-house 61-274 (278) alignment
Range on Protein: 925-1117
Range on HMM: 61-274/278.0
GYreKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSSD----KEAISRNVLQ
||  ...||..| |...|| |||.|. ......||||.....     |..|| .|    |... .....| . . || |...|       ..  ||.| .
gy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvth

LQVADWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVT
|.   ||  ||  .|  . .|.... . .....             .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||.
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavq

TLEQYTSIYDVIDMYLQM
.||||  .|... ..|..
nleqyrflyefllelllr

subfamily_CG7180_pd Subfamily CG7180 925-1117 1.6e-37 123.7 In-house 80-292 (296) alignment
Range on Protein: 925-1117
Range on HMM: 80-292/296.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC---CFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVSSD----------KEAIS
..  |...|. . |...|| .||... | ..||.|.|. . |    .  ||      .| |  .|...| .    . |.||.              .|  
sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaet

RNVLQLQVADWPQ-DGVVREPRTVLQVIDDVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
| |...|.  |.  | |     ......  |   ..|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|
RivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeY

TSIYDVIDMYLQM
  ||||.  .. .
kyiYdvlleavlc

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 925-1112 2.4e-35 117.0 In-house 85-276 (288) alignment
Range on Protein: 925-1112
Range on HMM: 85-276/288.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGRKYDEYG---LEVTNEINSNGYTERMFKVSsdKEAISRNVLQLQV
|...|...| .|.|. .|| |||... ..|.| |||| .    ..  |  || .. |  .||   ...... . . ...| . .   |.   ... |.| 
gekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqy

ADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
  ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
laWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPRB_pd Subfamily PTPRB 925-1116 2.2e-34 113.8 In-house 89-286 (293) alignment
Range on Protein: 925-1116
Range on HMM: 89-286/293.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC--GE--EDCCFPYWLSGRKYDEYG---LEVTNEINSNGYTERMFKVSSdkEAISRNVLQLQV
||. .| || .| |. .|| |||.|... |.|.||||    |     |  || . ..   ||   .....| . . .. | .|..   |  .|.| |.. 
gynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhf

ADWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
  ||. ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr





subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 925-1116 6.4e-33 109.1 In-house 79-277 (281) alignment
Range on Protein: 925-1116
Range on HMM: 79-277/281.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVsSDKEAISRNVLQLQV
||......|..|.|. ... .||.|....|||||||.  | .     |  ||  ..   || .. .. |.| ... | || ||. . ... .|.| ||. 
gykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlay

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
  ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|.
taWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald





0041856 (Phosphotyrosine protein) phosphatases II 925-1117 3.3e-29 97.2 In-house 29-173 (182) alignment
Range on Protein: 925-1117
Range on HMM: 29-173/182.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCgeedcCFPYWLsgrkydeyglevtneinsngytermfkvssdkEAISRNVLQLQVADWPQDG
|..  . ||..| |. .|| ||..|. ......||.|.     ...||                                 |   |...|..   || .|
gslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp................................ellerlgiqylylpwpDhg

VVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  ..... ..|. 
vpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 925-1114 7.5e-28 92.3 In-house 67-258 (267) alignment
Range on Protein: 925-1114
Range on HMM: 67-258/267.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC--GEEDC--CFPYW-LSGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAiSRNVLQLQVAD
||. |.|||. | |..||. ||...| |.||. ||.|   ....    .|      .||..  .| . | . | |    ...   .|. ..||       
gyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykk

WPQDGvvrEPRTVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|  .    . .  |. .  .  . | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....  |
wnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0036282 (Phosphotyrosine protein) phosphatases II 925-1109 1.3e-26 88.8 In-house 12-164 (174) alignment
Range on Protein: 925-1109
Range on HMM: 12-164/174.0
GYREKRAFIIAQSPMEntvrdFWKMILDYKVSAIVMLCGEED----CCFPYWLSgrkydeyglevtneinsngytermfkvssDKEAISRNVLQLQVADW
...  . .|. | |..     ||.|. .......|||. |.      |. || .                             ..|  .|...|..   |
lsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredlerlgiqylylpw

PQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
pDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

0043147 (Phosphotyrosine protein) phosphatases II 925-1110 2.3e-26 87.9 In-house 15-156 (172) alignment
Range on Protein: 925-1110
Range on HMM: 15-156/172.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEedccfpywlsgrkydeyglevtneinsngytermfkvSSDKEAISRNVLQLQVADWPQDG
.|.  . ||. | |. ||. |||.|. ......||.|...                                       |.|  .|...|..   ||  |
lyyipdrfiatqgplrntladfwrmlkelgithivnltel.....................................lydpellerlgiqylylpwpDhg

VVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|. 
vp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf

0049260 (Phosphotyrosine protein) phosphatases II 925-1109 4.6e-24 80.3 In-house 4-144 (152) alignment
Range on Protein: 925-1109
Range on HMM: 4-144/152.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWlsgrkydeyglevtneinsngytermfkvssdkeaisrnvlQLQVADW
||. ...||..| |..||. |||.|. ......||||. ...    .|  |.                                         | .   |
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpw

PQDGVVREPRTVLQvIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .||   .  .|. . ..|.. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
pDhgvpdlsqlllf.lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 926-1117 2.3e-36 120.3 In-house 68-270 (274) alignment
Range on Protein: 926-1117
Range on HMM: 68-270/274.0
Y-REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EE--DCCFPYWLSGRKY------DEYGLEVTNEINSNGYTERMFKVSSDKEaiSRNVLQ
| .|..|.. .| |. ||| |||.||   .|. ||||    |.  . |  |.   ..|      ..  ..|.. .. |.|. | . ... ..  .|.|  
ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkh

LQVADWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
   .|||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  .|  . | | | |||  |. .. 
ywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

MYLQM
.||. 
lylkr

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 926-1117 1e-34 114.8 In-house 83-279 (315) alignment
Range on Protein: 926-1117
Range on HMM: 83-279/315.0
YREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EEDC--CFPYWLS----GRKYDEYGLEVTNEINSNGYTERMFkvSSDKEAISRNVLQLQV
. . .|.| .| | . .| |||.|.|..||..|||.    |.|   |  ||        .. .. .|. .     . . | .     |   ||.| | | 
vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqf

ADWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 .||. || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|. 
tewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllw





subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 926-1114 5.8e-33 109.4 In-house 87-287 (325) alignment
Range on Protein: 926-1114
Range on HMM: 87-287/325.0
YREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVML---CGEEDCCFPYWLSG-RKYDEY-GLEVT----NEInsNGYTERMFKVSSDKEAISRNVLQLQ
...|  |. ||.|. .|. |.|...||.. | .|.|    ...| |  ||     |  .. ||||     .||    |  |...|   |.  .| | |.|
dkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei..sdyvhrvldvkqvkkGetrsvkqfq

VADWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. .
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

DMY
  .
vea

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 926-1111 1.4e-24 81.2 In-house 84-232 (392) alignment
Range on Protein: 926-1111
Range on HMM: 84-232/392.0
YREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EEDccfpywlsgrkydeyglevtneinsngytermfkvssdKEAISRNVLQLQVADWPQD
.  ..|.| .|.|   .. |||.|... .|..|.|.    | |                                      |    | | | ....||..
fdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......................................kgddartvaqfhftewPdk

GVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | |||. ||  .
dvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

0049772 (Phosphotyrosine protein) phosphatases II 926-1117 8.6e-20 67.1 In-house 83-282 (314) alignment
Range on Protein: 926-1117
Range on HMM: 83-282/314.0
YrekRAFIIAQSPMENTVRDF----------WKMIL--DYKVSAIVM---------------------LCGEEDCCfpywlsgrkydeY----------G
.   ..||..| |.|.|| ||          |.|.|  |..|  |||                     |..                             
f...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............neptaadlellk

levtneinsngytermfKVSSDKEAISRNVLQLQVADWPQdGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvD
                 ..  |.|  .|.....   ..|  | .  .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   || .
.................eelydpelferlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.s

VFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDMYLQM
. .. . ||.  |     |.. .||||  |.... .||..
leealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_PTPN12_pd Subfamily PTPN12 927-1116 5.4e-35 115.7 In-house 80-278 (290) alignment
Range on Protein: 927-1116
Range on HMM: 80-278/290.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLSGRK----YDEYGLEVTNEIN-SNGYTERMFKVSSDKEaiSRNVLQLQV
 .| ..| ||.|. .|. |||.|| ...|. .||.| |       |  || .  .    ..|. .....| . ..... |..||  .||  ||.| |.. 
egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqke..srkvyqfhY

ADWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 .||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  .  .
taWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

LQ
.|
vq

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 927-1116 4.6e-34 112.4 In-house 83-277 (515) alignment
Range on Protein: 927-1116
Range on HMM: 83-277/515.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLS----GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEaiSRNVLQLQVA
   .|.| .| | . .| |||...|...|..|.|.   .      |  ||        |. .. .|.       | . | ..|  ...  || | | .  
dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhft

DWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .| 
eWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 927-1118 5.4e-31 102.6 In-house 61-267 (270) alignment
Range on Protein: 927-1118
Range on HMM: 61-267/270.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGRK----YDEYGLEVTNEI--NSNGYTERMFKVSsdKEAISRNVLQLQ
 ||...| |..|...|...||.||.. ||.||||. |      . |  || . .|    . .  ..|...   ...||  .  ..   ... .|...  .
gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfw

VADWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
  .||..||.||.        .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .| 
yntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyk

VIDMYLQMN
.. .| .. 
avveyaerr

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 927-1117 4.6e-17 57.0 In-house 79-273 (288) alignment
Range on Protein: 927-1117
Range on HMM: 79-273/288.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC-----GEE--DCCFPYWLsGRKyDEYGLEVTNEINSNGYTERMFKVSS---DKEAISRN-VLQL
. || .| ||.|.. |.  .|||.|.  |  |||||     | |  .  ||  | |.|   .|   |   ...   ... |||     ||   .  | .|
kykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gek.arigrlctvvkkkradidklvkvsllriskegeekvivkil

QVADWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  ||  .. ..  .|
hlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

QM
 .
ll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 927-1115 1.9e-11 38.5 In-house 72-270 (285) alignment
Range on Protein: 927-1115
Range on HMM: 72-270/285.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC-----GEEDCCFPYW--LS-GRKYDEYGLEVTN--EINSNGYTERMFKVSSDKEAISRNV--LQ
... ..| .| |. .|. |||.|| . |.. ..|||     | | |.. |   |    |. .| . .|.  |    |     . |   ..| |  .   .
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

LQVADWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
.||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .   .  ...... . .|  .  || .  |.  .| |.  |
vqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

L
.
f

subfamily_PTPN6_pd Subfamily PTPN6 928-1119 6.4e-39 128.7 In-house 96-301 (306) alignment
Range on Protein: 928-1119
Range on HMM: 96-301/306.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGRKYDEYG---LEVTNEINSNGYTERMFKVS-SDKEAISRNVLQLQVAD
.....| .|  .|.|| |||.|... .   |||.  | .     | .|| .  . .|||   .. ..| . . |. | ..||  .|.  .|.| |..  .
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

WPQDGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
||. || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| .
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

YLQMNS
|.. ..
yietkk

subfamily_PTPN14_pd Subfamily PTPN14 928-1116 1.1e-28 95.1 In-house 91-297 (300) alignment
Range on Protein: 928-1116
Range on HMM: 91-297/300.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPYWLSG------RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQV
..| .|.||.|.|.||.|||.|. . .|. ||||  |     . .| |. .        ..... .      .|. .. . .|.        |.|. || 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy

ADWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.|||..|| ..... |. ...|    .  ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYk

VIDMYLQ
|.  ||.
vlikylk

subfamily_PTPN13_pd Subfamily PTPN13 928-1116 1.8e-28 94.6 In-house 75-270 (273) alignment
Range on Protein: 928-1116
Range on HMM: 75-270/273.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSG--RKYDEYG---LEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
..  .|..| |. .||.|||.|. . |.. |.|.  | .     |  || .   .|   ..   .|. .  . .|.. | ..|.  . . ||.| .|. .
deyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfv

DWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.||  || ...  .||..  | . |.    ||.|||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .|   |.
kwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPN1_pd Subfamily PTPN1 928-1108 2e-23 77.6 In-house 69-264 (290) alignment
Range on Protein: 928-1108
Range on HMM: 69-264/290.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGRK-----YD--EYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
 || .|..| |. |||  ||.|. . |  |.|||      |.  |. || .| .     ..  .. ... .| ... || |....   |   .|..|.  
akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfh

VADWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
yttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 928-1110 1.3e-15 52.1 In-house 3-199 (199) alignment
Range on Protein: 928-1110
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE---DCCFP-YWLSG----RKYDEYGLEVTNEINSNGYTERMFKVSSDKEA--ISRNVLQLQV
 .| .| .| |. .|. |||.|. .     |||.  ..   .. .| || .      ||    . .        ||   . ....  |   .|.. . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

ADWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
. | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 928-1120 8.8e-15 49.2 In-house 86-292 (305) alignment
Range on Protein: 928-1120
Range on HMM: 86-292/305.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLSGRK----YDEYGLEVTNEINSNGYTER----MFKVSSD------KEAIS
. . || .|.|.|.|  ||| | |. || || |||         |. |. |  |    ..| |  ..  ..| .  .       ||.          . .
npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgeka

RNVLQLQVADWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRRSKPGAVTTLEQYTSIY
| | .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  ..
rkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

DVIDMYLQMNSM
.||  |.. . .
qvilnyfrkkkl

0037934 (Phosphotyrosine protein) phosphatases II 929-1114 1.9e-39 131.0 In-house 44-241 (243) alignment
Range on Protein: 929-1114
Range on HMM: 44-241/243.0
KRaFIIAQSPMENTVRD----FWKMILDYKVSAIVMLCGEE----DCCFPYWLSGRKYDEYGLEVTNEINSNGYTERMFKVSSDK-EAISRNVLQLQVAD
.| .|. | |...|| |    ||.|. ......||||. ..      |..|| ..  |...  ....| . ..|| |.....  . .  .|.| ...   
pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylp

WPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVI
||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .|...
wpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeal

DMY
 ..
lel

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 929-1118 1.4e-37 124.5 In-house 91-287 (297) alignment
Range on Protein: 929-1118
Range on HMM: 91-287/297.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE---DCCFPYWLSGRK--YDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQD
|  .|  | ||..|| |||.|.||..||.||||  ..   . |  ||       . .  ....   . .|. .| ..|. .|    | | | |  .||..
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdk

GVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .|  .
averkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 929-1108 5.8e-23 76.3 In-house 50-233 (239) alignment
Range on Protein: 929-1108
Range on HMM: 50-233/239.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWL-SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQD
 .|.| .|  .| .  |||.|. . .   |||| |     .  |. ||  |  || .  . . .      |  | | .|   ..  | | | ... ||. 
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk

GVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
gvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 929-1108 5.9e-23 76.3 In-house 51-234 (239) alignment
Range on Protein: 929-1108
Range on HMM: 51-234/239.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWL-SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQD
 .|.| .|  .| .  |||.|. . .   |||| |     .  |. ||  |  || .  . . .      |  | | .|   ..  | | | ... ||. 
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk

GVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
gvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_PTPRN_pd Subfamily PTPRN 929-1109 1.3e-21 71.6 In-house 99-286 (297) alignment
Range on Protein: 929-1109
Range on HMM: 99-286/297.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLS-G-RKYDEYGLEV-TNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWP
. |.| .|.|. .|| |||.|. .  |  ||.|.  |.     |  ||   |   |. | ... .. | .. |  | | .   .   .| | |.    ||
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp

QDGVVREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
. ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
eegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 929-1111 5.1e-21 69.6 In-house 93-279 (290) alignment
Range on Protein: 929-1111
Range on HMM: 93-279/290.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPYWLS--GR--KYDEYGLEVTNEINSN-GYTERMFKVSSDKEAISRNVLQLQVAD
|  ||..| ....|| |.|.|.|. ||.||||||         | .|.    |.   . |. .  ..| . .     ... |   ..  .  .  |..  
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...
wpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 929-1104 9.4e-18 59.0 In-house 89-270 (301) alignment
Range on Protein: 929-1104
Range on HMM: 89-270/301.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCC---FPYWLSGR-KYDEYGLEVTN--EINSNGYTERMFKVS-SDKEAISRNVLQLQV
 . ||..|.|..||  ||| |.  |.|  ||||. .    |. |   .| . | . . . . ....|   | ..  ..| ..|  | ..  .| |.  | 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

ADWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
..|.. || .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| | .| 
sewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 929-1115 2e-16 54.9 In-house 81-277 (307) alignment
Range on Protein: 929-1115
Range on HMM: 81-277/307.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGRKYDEYGLEVTN--EINSNG-----YTERMFKVSS---DKEAISRNVLQ
 . || || |.|||. .|| |... || ...|||   .     |  ||   .       | .|   ..  |       | . .|..   |    || . .
pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqh

LQVADWPQDGVVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
||  .||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  
lqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

YL
|.
yf

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 929-1110 1.6e-15 51.8 In-house 3-198 (198) alignment
Range on Protein: 929-1110
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE---DCCFP-YWLSG----RKYDEYGLEVTNEINSNGYTERMFKVSSDKEA--ISRNVLQLQVA
.| .| .| |. .|. |||.|. .     |||.  ..   .. .| || .      ||    . .        ||   . ....  |   .|.. . | .
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 929-1111 2.2e-15 51.1 In-house 80-265 (281) alignment
Range on Protein: 929-1111
Range on HMM: 80-265/281.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWL----SGRKYDEYGLEVTNEI-NSNGYTERmFKVSSDKEaiSRNVLQLQVAD
|| .|..| | ..|  |||.|| . . .||||||     . . |  |.        ..|.. ..  .   |    | | ...| . |  .| . .    .
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.lnlsyege..trlithwlwke

WPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGAVTTLEQYTSIYDVI
||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.||  |. |.
wpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 929-1110 1.3e-14 48.5 In-house 93-285 (310) alignment
Range on Protein: 929-1110
Range on HMM: 93-285/310.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EE--DCCFPYWLSGRKYDEYG-LEVTNEINSNGYTE--------RMFKVSSDKEAISRNVLQL
. .|| .| |.. |. |||.||.. .  .|..||   ||    |  || |    . || . |||  .|    |           .|  |..    . |..
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

QVADWPQDGVVREPRTVLQVIDDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
..  ||.      |    . . . .  |  .  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  |
slikwpnwpdrgvpdekchtvpqrllaq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 929-1026 1.5e-07 25.8 In-house 27-127 (130) alignment
Range on Protein: 929-1026
Range on HMM: 27-127/130.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDCcFPYWLSGRKYDEYGLEVTNE----INSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDG
 . .. .| |. .|  |||||.|.  |  .|.|   |.    ||     .. |  ...       ...      ....||     . .  .|...|| ||
taeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.deywpdsePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdg

VV
  
tt

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 929-1120 2.7e-06 21.2 In-house 83-284 (303) alignment
Range on Protein: 929-1120
Range on HMM: 83-284/303.0
KRAfIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE-------EDCCFPYWLSGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ-VADW
|.| |..| |.  |  |||.||.. ||  ...|  .        |  ||      |..|  . | .  . .      .|| |  .   .  |...   .|
kka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykaw

PQDGVVRE--PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIG-LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|.. .  .  |. | |. .     ..   . | |      . |.| ..      |   . .  .|. .. . ||  .  ||  | |.. .| ..  ..  
phnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld

NSM
| .
ngi

subfamily_PTPN3_pd Subfamily PTPN3 930-1111 2.5e-29 97.1 In-house 84-271 (280) alignment
Range on Protein: 930-1111
Range on HMM: 84-271/280.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQ
  .|..| |...|. |||.|. . |.| ||||          |  || .     .| |. .....| ... |  | . ..  ..  .|..||||  .||.
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpd

DGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||  ..  .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 930-1111 5.7e-28 92.7 In-house 45-235 (237) alignment
Range on Protein: 930-1111
Range on HMM: 45-235/237.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGRKYDEYGL---EVTNEINSNGYTERMFKVSSDKEA-ISRNVLQLQVADWP
. .| || |.|..  |||.|. . | | |||| |    .|  |  || |  .   ||     .. . .   || | . .|   .    | . | | . ||
kkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswp

QDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_egg_pd Subfamily egg 930-1115 2.6e-16 54.2 In-house 83-270 (307) alignment
Range on Protein: 930-1115
Range on HMM: 83-270/307.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE--DCCFPYWLSGRKYDE----YGLEVTNeINSNGYTERMFKVSSDKEaISRNVLQLQVADWPQD
  ||.||.|. ||| |||.|.   .|  ||||      . |  ||    .        .|...| .. .  .. .|.|.  |  .  .  .. .  |  |
nefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrien.lkvdskadplfrvtklkl.vGgddeerflehwqgd

gvVREPRTVLQVIDdvIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV--DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  |..   |   .   . |. .    ||||.. . ||....  .. | | .     ..   | .  . .|. .. .| .  .|  .| .. ...
..vnnssdvysplr..vlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 930-1118 5.9e-16 53.4 In-house 60-262 (290) alignment
Range on Protein: 930-1118
Range on HMM: 60-262/290.0
RAFIIAQSPMEN-------TVRDFWKMILDYKVSAIVMLCGEED--------CCFPYWLS----GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAiSR
 ..|. ||| |.       |. .|| |. . ||  .||||  |.         |  |         |..   .. .. .. ..  .|   |  |.|    
lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddee.ef

NVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 |   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. .... .  
tvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

VIDMYLQMN
.| ....  
givllaiev

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 930-1115 5.3e-15 49.8 In-house 96-289 (305) alignment
Range on Protein: 930-1115
Range on HMM: 96-289/305.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWL--SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAIS------RNVLQLQV
. || || |...|. .|| |... ||  |||||         |  ||    | | .  .  | ...  .   ||  ..      ..        | .|| 
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqw

ADWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGLEQCKA-EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |. |.  |.
tewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_ptpA1_pd Subfamily ptpA1 930-1072 2.3e-12 41.4 In-house 89-253 (418) alignment
Range on Protein: 930-1072
Range on HMM: 89-253/418.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED-C---CFPYW---LSGRKYDEYGleVTNEINSnGYTERMFKVSSD--KEAIS-----------
. || .| |. ||. |||.|. . ..  ||||  | . |   |  ||   . | ..  ||    ||.    |.  . .|  |  .| |.           
kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiyg..ngnevfg.tysvelveviqdpereiitrnirltfeget

RNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
|.. | |   ||.  .    . . |..  .  ||..|        |..||||  | |.| .|.  | .
rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 930-1117 3.1e-12 40.5 In-house 90-287 (302) alignment
Range on Protein: 930-1117
Range on HMM: 90-287/302.0
RAFIIAQSPMENTV---RDFWKMILDYKVSAIVMLCGEEDC------CFPywLSGRKYDEYGLEVTNEI--NSNGYTERMFKVSSDKEAISRNVLQ--LQ
|  |.|| |  ...    .||.|. . |.  .|.| |||..       ||  .   .| |||    |    ..   .. .. .    | .|  ||     
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfp..kksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv

VADWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.  |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|..
ltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

M
 
k

subfamily_PTPN23_pd Subfamily PTPN23 931-1112 1.2e-30 101.4 In-house 84-277 (288) alignment
Range on Protein: 931-1112
Range on HMM: 84-277/288.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDCCFP----YWLS----GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQ
 ||..|.|...|. |||.|. . |.| ||||  .|.   |    || .      |.... . . .. ... . ||..|..  ..   ..|  ||.  ||.
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

DGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 ||   | |.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |... 
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl

0046846 (Phosphotyrosine protein) phosphatases II 931-1115 7.6e-24 79.8 In-house 24-173 (176) alignment
Range on Protein: 931-1115
Range on HMM: 24-173/176.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGRKYDEyglevtneinsngytermfkvssdkeaisrnvlQLQVADWPQDGVV
..|. | |...|. ||..|.......|.|.|. | .     |. ||   .|..                                  | .. .||  || 
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.................................qylhlpwpDhgvp

REpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDMYL
   . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|... ..|
dl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 931-1111 3.5e-15 50.7 In-house 77-291 (297) alignment
Range on Protein: 931-1111
Range on HMM: 77-291/297.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGRKYDEYGLEVTNEINSNG---YTE-RMFKVSSDKEAISRNVLQLQVADWPQ
 .|.|| |...|| |||... .  | .|||..    .  | |.||| |  .      .|  |  |.    .    . ..     . || |   |   ||.
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpd

DGVVR----EPR-------------TVLQVID---DVI------HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPG
 ||        |              .| ...    ..       | ..    ...||||  | ||||     . |.. . . . ||  . . .|  .. 
hGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrar

AVTTLEQYTSIYDVI
 | ||||.. .||..
lvqtleqfellydav

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 931-1121 1.6e-12 41.7 In-house 83-282 (312) alignment
Range on Protein: 931-1121
Range on HMM: 83-282/312.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPY---------WLSGRKYDEYGLEVTNEINS-NGYTERMFKVSSDKEAISRNVLQLQ
 |...|.|.|||.  ||.. |    ..|..|||      . |  |             | | ||  |.    .| .  | |..||         .. . |
rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyq

VADWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVtkaVRRSKPGAVTTLEQYTSIYDVIDM
 | ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| .   .|. .  .| .. ||     ..  
waswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvle

YLQMNSMY
.|  ...|
flyskgly

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 931-1026 1.1e-07 25.7 In-house 138-236 (244) alignment
Range on Protein: 931-1026
Range on HMM: 138-236/244.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EEDccfPYWLSGRKYDEYGLEVTNEI----NSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDG
 .|..| |. .|  |||||.|. .|  .|.|    |||    ||      . |  ..|  .    .        ... || .   . .  .|...|| ||
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed...eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

VV
  
tt

0051082 (Phosphotyrosine protein) phosphatases II 932-1110 5e-20 67.1 In-house 15-148 (151) alignment
Range on Protein: 932-1110
Range on HMM: 15-148/151.0
FIIAQSPMEntvrDFWKMILDYKVSAIVMLCGEE--DCCFPYWLS-GrkydeyglevtneinsngytermfkvssdkeaisRNVLQLQVADWPQDGVVRE
... . |..    ||.... ......||.|..||  . |  |. . |                                  ..||.... |||  |.   
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................ievlhipildwpdpglpls

PRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
. .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
fdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

0044763 (Phosphotyrosine protein) phosphatases II 932-1119 4.3e-18 61.0 In-house 30-175 (178) alignment
Range on Protein: 932-1119
Range on HMM: 30-175/178.0
FIIAQSPMentvRDFWKMILDYKVSAIVMLCGEEDCC----FPYWLSGRKydeyglevtneinsngytermfkvssdkeaisRNVLQLQVADWPQDGVVR
..... |.     |..... ......||.|..|  .     .|||...                                   ..|.. . |..   . .
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................iqylhipipDhgvpdlle

EPRTVLQVIDDVIhrqqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDMYLQMNS
  . ... |....    .  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..  ..|....
hflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkesd

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 936-1107 3e-13 43.9 In-house 97-280 (302) alignment
Range on Protein: 936-1107
Range on HMM: 97-280/302.0
QSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLS----GRKYDEYGLEVTN-EINSNGYTER----MFKV----SSDKEAISRNVLQLQVA
  |  .|.  .| .| .|.|. .| ||.    ||  | .|.        |. .| ..  . . . . .|..    ...|    .  |..  . |  |. .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 942-1123 4e-06 21.1 In-house 40-230 (255) alignment
Range on Protein: 942-1123
Range on HMM: 40-230/255.0
TVRDFWKMILDYKVSAIVMLCGEE-----DC--CFPYWLSGR-KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVL
||  |...|   | . .||||  .     .|   ||  . .. |. .  . .|. ..      .       .    ..|   .   |..    ...| .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QVIDDVihRQQKigggPVVVHCSDTVSRSGVYCSVSI-------GLEQCKAeGVVDVFQVTKAVRRSKPGAVTTLEQ-YTSIYDVIDMYLQMNSMYGN
...  |  |. |    .||||||  . ||  .  . .        |.. .. . .|  .. . .| ....|. |  |   ||. |.|..   . .  .
nilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak

0048179 (Phosphotyrosine protein) phosphatases II 950-1109 1.3e-12 43.2 In-house 25-139 (144) alignment
Range on Protein: 950-1109
Range on HMM: 25-139/144.0
ILDYKVSAIVMLCGEEDCCFPYWLsgrkydeyglevtneinsngytermfkvssdkeaisrnVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQkiGGG
. ........ |. | .  |.                                         ..|..  .||  ||   .  .|.... . . ..   ||
lkklgittvinlteeyepeflere......................................giqylhlpwpDhgvpdllellleflefieeale..egg

PVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
pvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 982-1114 1.7e-14 49.2 In-house 36-142 (145) alignment
Range on Protein: 982-1114
Range on HMM: 36-142/145.0
GlevtneinsngytermfkvSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvV
                    .|..|  .|...|..  .||  ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |
l...................tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.v

DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
..... . ||.  ||||.. .|.  .|... ..
sleealelvrsqrpgavpnpgqlrflyefelel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1011-1073 2.6e-06 21.4 In-house 216-287 (350) alignment
Range on Protein: 1011-1073
Range on HMM: 216-287/350.0
NVLQLQVADWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
 |.||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls

PTPc_DSPc_SM00012 1012-1111 2.7e-23 77.5 In-house 2-103 (105) alignment
Range on Protein: 1012-1111
Range on HMM: 2-103/105.0
VLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .... .||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al

subfamily_CG42327_pd Subfamily CG42327 1047-1115 4e-12 40.4 In-house 246-315 (319) alignment
Range on Protein: 1047-1115
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1052-1111 2.3e-07 25.1 In-house 2-61 (69) alignment
Range on Protein: 1052-1111
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1052-1112 8.2e-07 23.3 In-house 1-61 (69) alignment
Range on Protein: 1052-1112
Range on HMM: 1-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv