Gene PTPRD-59 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP116_AA protein Get Run
AqueP116_AA_423-567 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Imm12 Immunity protein 12 184-282 7.2e-06 12.3 Pfam-A 16-113 (155) alignment 
Range on Protein: 184-282
Range on HMM: 16-113/155.0
TVTITWDGMNVSNGSISQSTTGDQMYQCRVADHPGAaaIRIRNVTIKVPATAPSSLTEVNKTATTitVNWTALDSSDADGYVVNVTSD---TDTVQTVQV
.|  .| |.. .. .  ..|..|    | | .. |   | . . .  | .  | . | ... ..   | |.| || .    .|. . .    .......|
svlaqWkGadetglvegeetaddYdraCevdglaGv..iavgeaqalVlgdePaattylpehraf..vrwlaadseadllaaveavleaaeweeevkwev

EG
.|
dg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 367-574 1.8e-71 235.3 In-house 171-301 (301) alignment 
Range on Protein: 367-574
Range on HMM: 171-301/301.0
GgvnysqsvmlhapsgppnnvrgfilnatsikvnwtnssetngyvieyttggvtrnvvstneeeivltdlspmstyTISVYSYIDLPSVNSTVRVLRFDV
.                                                                             .. . ..  | .|.  ||...|
n...........................................................................ngyierkfkvksdksswdvlqlqv

ASdrLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
..     ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
td..WpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

QMNETYGN
|.|.||.|
qlnstyan
fn3 Fibronectin type III domain 383-449 1.8e-08 27.6 Pfam-A 2-76 (85) alignment 
Range on Protein: 383-449
Range on HMM: 2-76/85.0
PPNNVRGFILNATSIKVNWTNS----SETNGYVIEYTTGGVT----RNVVSTNEEEIVLTDLSPMSTYTISVYSY
.| |..    ..||. ..|. .    ..  || .|| . | .    .  |. .... .||.| | ..|...|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 417-559 3.7e-11 37.0 In-house 150-281 (302) alignment 
Range on Protein: 417-559
Range on HMM: 150-281/302.0
GGVTRNVVSTNEEEivLTDLSPMSTYTISVYSYIDLPSVNSTVRVLRFDVASDRlasdGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVY
  |.   | |. ||  .||   .  ||. .  .     |. || .| |    |     |  .|. | |...      ...     |.||||  | |.|  
ytvktvsvktdlee..ftdkksfklytveiknekkkkkvkktvdilafsawpdh....Gapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtl

CSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 ..  |.. |. . | |. .. . ||. . ||| . .| . . 
vaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
0045098 (Phosphotyrosine protein) phosphatases II 424-570 2.5e-19 65.2 In-house 116-276 (278) alignment 
Range on Protein: 424-570
Range on HMM: 116-276/278.0
VSTNEEEIVLTDLSPMSTYTISVYSYID-----LPSVNSTVRVLRF-DVASDRLASDGVVREPRTVLQVIDDVIHRQQKI---------GGGPVVVHCSD
.  .. .. |.. . ...||. .. ...         . .|..| .  .      |. ...    .|. |.... . ..          .||||.|||| 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

TVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDTYLQMNE
 |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|...  .|....
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_PTPN13_pd Subfamily PTPN13 424-568 1.4e-12 42.4 In-house 132-271 (273) alignment 
Range on Protein: 424-568
Range on HMM: 132-271/273.0
VSTNEEEIVLTDLSPMSTYTISVYSYIDLPSVNSTvRVLRFDVASdrLASDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGL
. .|  |. | ..  .......    .|. | .|  .| ... ..      || ...  .||..  | . |.    ||.|||||  . |||.. .. . |
kvsnrlevellkvqkldgfvvralavkdsesgesr.evahlnfvk..wPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvl

EQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
.  . .  .|| .. . .|. . | | | .||  .| .| . |..
glierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 427-571 6.4e-40 132.2 In-house 146-288 (305) alignment 
Range on Protein: 427-571
Range on HMM: 146-288/305.0
NEEEIVLTDLSPMSTYTISVYSYIDLPSVNSTVRVLRFDVASdrLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC
.| .. |.. . .| |..  ..     . . .  ||.. . .     .||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..
gefsvelksektasdyieRklkisiededkesrtvlqyqltd..WPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl

KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
|.|.|||||.|.|..|......|.||.||....|..| ...  .|
kkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
0046845 (Phosphotyrosine protein) phosphatases II 427-573 3.7e-23 77.7 In-house 133-281 (284) alignment 
Range on Protein: 427-573
Range on HMM: 133-281/284.0
NEEEIVLTDLSPMSTYTISVYSYIDLPSVNSTVRVLRFDVASDRlaSDGVVREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
..  . |..   ...||. . .  .|   . ...|  | . |     .||  .|. .|. ...| . ...  ||||.|||||. |.|.|... . . |||
gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleq

CKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETYG
 ..||   .|||... | .|. .||.|.|||||  .|...  ||..  |. 
lekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 428-575 9.2e-32 105.2 In-house 142-287 (287) alignment 
Range on Protein: 428-575
Range on HMM: 142-287/287.0
EEEIVLTDLSPMSTYTISVYSYIDLPSVNSTVRVLRFDVASdrLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK
| .| |..   .. |..     .   . ... .| ......    | | | ||.|.| ||.. .. |.| | ...|||||||| ||...|.. .....||
eyniellneevnagyierklevknknkagdkqqvkqyqitn..WdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETYGNF
 |||.||||| |  |  |||.| | |||. |.|.. .||.  ||| .|
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0040439 (Phosphotyrosine protein) phosphatases II 430-565 3.8e-20 68.0 In-house 112-245 (249) alignment 
Range on Protein: 430-565
Range on HMM: 112-245/249.0
EIVLTDLSPMSTYTISVYSYIDLpSVNSTVRVLRFDVASDRlaSDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
 . |..   .. ||. .    .|   .....|| . . .     .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . ||| . 
tvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
|. ||.... | .|. .||||...|||  .|...  .
elgvdleeavkllrsqRpgavqnpeqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 432-565 3e-16 55.2 In-house 106-241 (243) alignment 
Range on Protein: 432-565
Range on HMM: 106-241/243.0
VLTDLSPMSTYTISVYSYIDLPSVNSTVRVLRFDVASDRlaSDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLE
 |.. . .. ||. ....  |.  . |  | ..   .      ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |.
tllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll

QCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDTY
..   | ||.... | .|. .|| ||.|..||  .|...  .
ll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 433-572 1.5e-34 114.2 In-house 152-289 (290) alignment 
Range on Protein: 433-572
Range on HMM: 152-289/290.0
LTDLSPMSTYTISVYSYIDLPSVNSTVRVLRFDVASdrLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV
|.. . ...|..   .  .  | ...  | .. . .    |.| | .| |.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.
llneetlneyierklevknknsagakqsvtqyqitn..wdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi

DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
||||| |  |  ||| |.| .||  |.... |||.  |||
dvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0045450 (Phosphotyrosine protein) phosphatases II 433-565 2.6e-20 68.8 In-house 169-303 (307) alignment 
Range on Protein: 433-565
Range on HMM: 169-303/307.0
LTDLSPMSTYTISVYSYID--LPSVNSTVRVLRFDVASdrlaSDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
|.. . .. ||. ..   |    .   ||... .         .||   . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..|
llseehldgytvrtlevtdldgtgesrtvthfhytgwp....dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqleke

GV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
|.   ||.... | .|. .||||...|||  .|...  .
gtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 434-572 1.2e-24 81.9 In-house 151-286 (318) alignment 
Range on Protein: 434-572
Range on HMM: 151-286/318.0
TDLSPMSTYTISVYSYIDlPSVNSTVRVLRFDVASdrLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD
..   .|.|..  ..      ....  | .....|   .  ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..||
keevelsdyvlrefkvtr.teeeesrqvrqyhyts..WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD

VFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
|||. | .|. ..  | | .||. ||||.  .|.  .|.
vfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
0051299 (Phosphotyrosine protein) phosphatases II 435-566 8e-22 73.5 In-house 155-286 (288) alignment 
Range on Protein: 435-566
Range on HMM: 155-286/288.0
DLSPMSTYTISVYSYIDLP---SVNSTVRVLRFDVASDRlaSDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV
.   ...||. .    .|      . . .|  | . .     .||   |. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.
seevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
|||... | .|. .||.|.|.|||  .|...  ||
vdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN1_pd Subfamily PTPN1 439-559 2.5e-08 28.0 In-house 143-264 (290) alignment 
Range on Protein: 439-559
Range on HMM: 143-264/290.0
MSTYTISVYSYIDLPSvNSTVRVLRFDVAsdRLASDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDV
 |.||....   .| . . |  .|.|     . .  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||.
ksyytvrllelenlkt.qetreilhfhyt..twpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdi

FQVTKAVRRSKPGAVTTLEQYTSIY
 .|  ..|. . | . | .|    |
kkvllelrkyrlGliqtadqlrfsy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 442-570 7.9e-10 33.0 In-house 152-281 (287) alignment 
Range on Protein: 442-570
Range on HMM: 152-281/287.0
YTISVYSYIDLPSVN-STVRVLRFDVASDRLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKA
|..  .  ||| . .   |. | .    |. ..   |   | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   
ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvir

VRRSKPGAVTTLEQYTSIYDVIDTYLQMNE
.|  . . | .  |.  .|. . || . | 
lreyraalvqavvqlrllyealvtyyktnp
subfamily_Ptp69D_pd Subfamily Ptp69D 453-571 8.8e-19 62.7 In-house 176-291 (307) alignment 
Range on Protein: 453-571
Range on HMM: 176-291/307.0
PSVNSTVRVLRFDVASDRlasDGV-VREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
. |. . .|. ..  . .   |    . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. 
gevedsrkvvqyhytgWk...DskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

LEQYTSIYDVIDTYLQMNET
||||. .|  .  | .. .|
leqYvflyralldyssygdt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 458-566 2.4e-15 51.5 In-house 177-288 (325) alignment 
Range on Protein: 458-566
Range on HMM: 177-288/325.0
TVRVLRFDVASdrLASDGVVREPRTVLQVIDDVIHRQQK-----IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
|  | .|.. |      || . | |.. ... | . ...      . .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | 
trsvkqfqlqs..wddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

EQYTSIYDVIDTYL
.||. ||. .  ..
dqyiliyealveay
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 459-572 8.2e-27 89.0 In-house 139-248 (250) alignment 
Range on Protein: 459-572
Range on HMM: 139-248/250.0
VRVLRFDVASDRlasdGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
|| | | |  |.    || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..
vrqlhfvvWPdk....gvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfv

YDVIDTYLQMNETY
| .|  .|.  | |
yeiilkaldsvedy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 470-563 3.4e-14 47.0 In-house 98-191 (440) alignment 
Range on Protein: 470-563
Range on HMM: 98-191/440.0
RLASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
     || .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . ...| ..|  | | |||. ..... 
gwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 471-562 3.6e-11 37.7 In-house 143-235 (237) alignment 
Range on Protein: 471-562
Range on HMM: 143-235/237.0
LASDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
    || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
wpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 472-572 8.9e-27 89.1 In-house 196-296 (298) alignment 
Range on Protein: 472-572
Range on HMM: 196-296/298.0
ASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
.. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|.  ..
pdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

Y
.
e
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 472-571 7.2e-25 82.7 In-house 189-288 (319) alignment 
Range on Protein: 472-571
Range on HMM: 189-288/319.0
ASDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
. ..| .. ...|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  .... .|
pdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_PTPRA_pd Subfamily PTPRA 472-567 2e-21 71.3 In-house 202-296 (330) alignment 
Range on Protein: 472-567
Range on HMM: 202-296/330.0
ASDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
   ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  |  
PdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
0039614 (Phosphotyrosine protein) phosphatases II 472-570 1.1e-20 69.7 In-house 194-293 (297) alignment 
Range on Protein: 472-570
Range on HMM: 194-293/297.0
ASDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNE
  .||   ....|.... | .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||..  .|. . 
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0050432 (Phosphotyrosine protein) phosphatases II 473-572 1.3e-22 76.0 In-house 209-305 (308) alignment 
Range on Protein: 473-572
Range on HMM: 209-305/308.0
SDGVVREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
 .||  .|. .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|...  ||.  .|.
dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0036941 (Phosphotyrosine protein) phosphatases II 473-571 7.5e-22 73.4 In-house 180-282 (297) alignment 
Range on Protein: 473-571
Range on HMM: 180-282/297.0
SDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
 .||   |...|. |. | ...... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|...  .|. 
dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

NET
..|
klt
0040438 (Phosphotyrosine protein) phosphatases II 473-573 3.6e-21 71.2 In-house 184-283 (317) alignment 
Range on Protein: 473-573
Range on HMM: 184-283/317.0
SDGVVREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 .||   |...|. .. | . ..  . ||||.||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||..  ||. ..|
dhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt

YG
. 
le
0047943 (Phosphotyrosine protein) phosphatases II 473-566 9.2e-21 69.9 In-house 178-272 (273) alignment 
Range on Protein: 473-566
Range on HMM: 178-272/273.0
SDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
 .||   .  .|. |..| . .... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|...  ||
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 473-565 1.4e-19 66.0 In-house 185-276 (278) alignment 
Range on Protein: 473-565
Range on HMM: 185-276/278.0
SDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
 .||   . ..|. . .|.....   .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|...  |
dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 473-571 2e-16 54.7 In-house 185-282 (315) alignment 
Range on Protein: 473-571
Range on HMM: 185-282/315.0
SDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
  || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|.  .|
dkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 473-568 3.2e-11 37.9 In-house 182-278 (281) alignment 
Range on Protein: 473-568
Range on HMM: 182-278/281.0
SDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
  ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|. 
dhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN23_pd Subfamily PTPN23 473-564 8.8e-11 36.1 In-house 183-278 (288) alignment 
Range on Protein: 473-564
Range on HMM: 183-278/288.0
SDGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
. ||   | |.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |... .
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
0051082 (Phosphotyrosine protein) phosphatases II 473-561 1.5e-10 36.3 In-house 72-148 (151) alignment 
Range on Protein: 473-561
Range on HMM: 72-148/151.0
SdgvvrePRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.        . .. . ....  .. ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
g......lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_PTPRD_pd Subfamily PTPRD 474-571 5.5e-25 83.0 In-house 190-286 (564) alignment 
Range on Protein: 474-571
Range on HMM: 190-286/564.0
DGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|.. .|
hgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
DSPc_SM00195 474-566 3.1e-21 71.2 In-house 171-262 (263) alignment 
Range on Protein: 474-566
Range on HMM: 171-262/263.0
DGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
 ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
hgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 474-566 3.1e-21 71.2 In-house 171-262 (263) alignment 
Range on Protein: 474-566
Range on HMM: 171-262/263.0
DGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
 ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
hgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 474-562 3.4e-21 71.1 Pfam-A 146-233 (235) alignment 
Range on Protein: 474-562
Range on HMM: 146-233/235.0
DGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
hgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 474-562 3.4e-21 71.1 In-house 146-233 (235) alignment 
Range on Protein: 474-562
Range on HMM: 146-233/235.0
DGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
hgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRK_pd Subfamily PTPRK 474-562 2.6e-20 67.5 In-house 186-273 (314) alignment 
Range on Protein: 474-562
Range on HMM: 186-273/314.0
DGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
hdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0042113 (Phosphotyrosine protein) phosphatases II 474-565 5e-19 64.1 In-house 150-242 (245) alignment 
Range on Protein: 474-565
Range on HMM: 150-242/245.0
DGVVRE-PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
|. | . ....|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  .|...  .
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 474-566 2.4e-17 57.9 In-house 188-280 (315) alignment 
Range on Protein: 474-566
Range on HMM: 188-280/315.0
DGVVREPRTVLQVIDDVIHRQQ-KIggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI-DTYL
 || .   .....|  |   .. ..  |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||.. .|..
mgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_PTPN6_pd Subfamily PTPN6 474-571 2.6e-17 57.8 In-house 199-302 (306) alignment 
Range on Protein: 474-571
Range on HMM: 199-302/306.0
DGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
 || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| .|..
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

MNET
 ...
tkkk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 474-571 1.2e-16 54.9 In-house 185-281 (515) alignment 
Range on Protein: 474-571
Range on HMM: 185-281/515.0
DGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .|   .|
kGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 474-568 6.8e-15 49.8 In-house 171-266 (270) alignment 
Range on Protein: 474-568
Range on HMM: 171-266/270.0
DGVVREPRTVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
.. . ... .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .| .. .| ..
edsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRB_pd Subfamily PTPRB 474-569 3.1e-14 47.7 In-house 192-288 (293) alignment 
Range on Protein: 474-569
Range on HMM: 192-288/293.0
DGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMN
 ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |.... ..|. .
hgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 474-563 1.2e-13 45.8 In-house 188-276 (288) alignment 
Range on Protein: 474-563
Range on HMM: 188-276/288.0
DGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
hgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0041856 (Phosphotyrosine protein) phosphatases II 474-569 2.2e-13 45.7 In-house 94-174 (182) alignment 
Range on Protein: 474-569
Range on HMM: 94-174/182.0
DgvvrePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMN
|     ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  .....  .|. .
d.....ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 474-561 3.9e-13 44.5 In-house 162-250 (284) alignment 
Range on Protein: 474-561
Range on HMM: 162-250/284.0
DGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
vgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
0043147 (Phosphotyrosine protein) phosphatases II 474-560 2.1e-12 42.6 In-house 75-155 (172) alignment 
Range on Protein: 474-560
Range on HMM: 75-155/172.0
DGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|. |  .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|.
DhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 474-560 8.3e-12 40.5 In-house 64-144 (152) alignment 
Range on Protein: 474-560
Range on HMM: 64-144/152.0
DGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|. | .   .|. . ..|.. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 474-570 8.5e-11 37.6 In-house 190-284 (314) alignment 
Range on Protein: 474-570
Range on HMM: 190-284/314.0
DGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDTYLQM
|| .  .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .||||  |....  ||..
Dgsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf

NE
 .
lk
0048076 (Phosphotyrosine protein) phosphatases II 474-563 8.7e-11 37.2 In-house 58-140 (145) alignment 
Range on Protein: 474-563
Range on HMM: 58-140/145.0
DGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |..... . ||.  ||||.. .|.  .|... 
hgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefel
PTPc_DSPc_SM00012 475-562 3.5e-20 67.5 In-house 14-103 (105) alignment 
Range on Protein: 475-562
Range on HMM: 14-103/105.0
GVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|| .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|...
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_PTPN12_pd Subfamily PTPN12 475-567 8.4e-14 46.1 In-house 184-278 (290) alignment 
Range on Protein: 475-567
Range on HMM: 184-278/290.0
GVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
|| . . ..|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  .  ..|
gvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 475-561 3.7e-13 44.5 In-house 199-286 (319) alignment 
Range on Protein: 475-561
Range on HMM: 199-286/319.0
GVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
GvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
0046846 (Phosphotyrosine protein) phosphatases II 475-566 9.5e-12 40.5 In-house 87-173 (176) alignment 
Range on Protein: 475-566
Range on HMM: 87-173/176.0
GVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDTYL
. | . . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|...  .|
hgvpdlelllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_PTPN3_pd Subfamily PTPN3 475-562 2.6e-09 31.4 In-house 185-271 (280) alignment 
Range on Protein: 475-562
Range on HMM: 185-271/280.0
GVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
||  ..  .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
gvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
0036282 (Phosphotyrosine protein) phosphatases II 476-560 1.9e-14 49.2 In-house 81-164 (174) alignment 
Range on Protein: 476-560
Range on HMM: 81-164/174.0
VVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 | .  ..|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
gvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0048179 (Phosphotyrosine protein) phosphatases II 476-560 5e-10 34.8 In-house 62-139 (144) alignment 
Range on Protein: 476-560
Range on HMM: 62-139/144.0
VVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|   .  .|.... . . ..   ||||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
vpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 477-567 2.4e-17 57.9 In-house 177-269 (274) alignment 
Range on Protein: 477-567
Range on HMM: 177-269/274.0
VREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
 ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  .|  . | | | |||  |. ..  ||.
PddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 478-563 8.1e-08 26.7 In-house 175-256 (290) alignment 
Range on Protein: 478-563
Range on HMM: 175-256/290.0
REPRTVLQVIDDVIhrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
....|.|..|. |        . ||.||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. .... .  .| 
edtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
0051429 (Phosphotyrosine protein) phosphatases II 479-573 3.4e-14 48.6 In-house 138-248 (272) alignment 
Range on Protein: 479-573
Range on HMM: 138-248/272.0
EPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ---
|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        .... . .|.  |||| | |||  .|...  .|    
ea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll

-------------MNETYG
             ..|.||
svraeyllaaldaideeyG
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 479-559 1.8e-11 38.6 In-house 154-233 (239) alignment 
Range on Protein: 479-559
Range on HMM: 154-233/239.0
EPRTVLQViDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
yatavlgl.rrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 479-559 2e-11 38.5 In-house 155-234 (239) alignment 
Range on Protein: 479-559
Range on HMM: 155-234/239.0
EPRTVLQViDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
yatavlgl.rrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0044763 (Phosphotyrosine protein) phosphatases II 479-570 2.9e-10 35.6 In-house 90-175 (178) alignment 
Range on Protein: 479-570
Range on HMM: 90-175/178.0
EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDTYLQMNE
. .  .. . . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..   .|....
dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 480-571 1.9e-17 58.4 In-house 198-289 (297) alignment 
Range on Protein: 480-571
Range on HMM: 198-289/297.0
PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .|  ..|
assllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 481-568 1.9e-11 38.0 In-house 300-387 (392) alignment 
Range on Protein: 481-568
Range on HMM: 300-387/392.0
RTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
|..|..|  |    ..     ..|||     |.||.|.    . |      ||.||  | .|  .   | | |.|. .||||  ||  
rsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylht
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 484-564 5.8e-11 36.5 In-house 197-277 (439) alignment 
Range on Protein: 484-564
Range on HMM: 197-277/439.0
LQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
|. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .  
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 487-562 1.7e-18 61.5 In-house 187-262 (283) alignment 
Range on Protein: 487-562
Range on HMM: 187-262/283.0
IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 491-562 1.3e-06 22.3 In-house 192-265 (281) alignment 
Range on Protein: 491-562
Range on HMM: 192-265/281.0
IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGAVTTLEQYTSIYDVI
| |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.||  |. |.
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 492-566 1e-14 49.2 In-house 185-259 (267) alignment 
Range on Protein: 492-566
Range on HMM: 185-259/267.0
HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
. | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....  | 
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_PTPN9_pd Subfamily PTPN9 493-566 1.7e-12 42.0 In-house 217-290 (297) alignment 
Range on Protein: 493-566
Range on HMM: 217-290/297.0
RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
 . .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | |||.  |  .  | 
wkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPRG_pd Subfamily PTPRG 494-571 4.8e-17 56.4 In-house 215-292 (563) alignment 
Range on Protein: 494-571
Range on HMM: 215-292/563.0
QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|..   .. .||
ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 494-568 7.2e-06 19.6 In-house 213-287 (302) alignment 
Range on Protein: 494-568
Range on HMM: 213-287/302.0
QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|.. 
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_CG7180_pd Subfamily CG7180 495-571 1.3e-21 71.5 In-house 219-295 (296) alignment 
Range on Protein: 495-571
Range on HMM: 219-295/296.0
QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
..   |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|  ||||.  .. .| .
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_CG42327_pd Subfamily CG42327 498-565 4.9e-12 40.1 In-house 246-314 (319) alignment 
Range on Protein: 498-565
Range on HMM: 246-314/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_PTPN14_pd Subfamily PTPN14 498-567 4.5e-11 37.3 In-house 228-297 (300) alignment 
Range on Protein: 498-567
Range on HMM: 228-297/300.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
   ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|. .||.
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 498-561 2.1e-10 35.1 In-house 134-199 (199) alignment 
Range on Protein: 498-561
Range on HMM: 134-199/199.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
   ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 498-561 2.1e-10 35.1 In-house 133-198 (198) alignment 
Range on Protein: 498-561
Range on HMM: 133-198/198.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
   ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 498-565 2.9e-08 27.7 In-house 215-282 (290) alignment 
Range on Protein: 498-565
Range on HMM: 215-282/290.0
GGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
  ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...  .
asGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPRN_pd Subfamily PTPRN 498-561 1.4e-07 25.6 In-house 223-287 (297) alignment 
Range on Protein: 498-561
Range on HMM: 223-287/297.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
   |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. .
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 498-573 3.7e-06 21.2 In-house 208-286 (307) alignment 
Range on Protein: 498-573
Range on HMM: 208-286/307.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL--QMNETYG
   |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  |.  .  ||| 
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 501-562 3.7e-08 27.6 In-house 230-291 (297) alignment 
Range on Protein: 501-562
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 503-563 8e-08 26.6 In-house 2-62 (69) alignment 
Range on Protein: 503-563
Range on HMM: 2-62/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 503-564 2.8e-07 24.8 In-house 1-62 (69) alignment 
Range on Protein: 503-564
Range on HMM: 1-62/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve