Gene PTPRD-60 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP118_AA protein Get Run
AqueP118_AA_239-419 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
ubiquitin Ubiquitin family 42-94 1.1e-06 17.4 Pfam-A 13-65 (69) alignment 
Range on Protein: 42-94
Range on HMM: 13-65/69.0
SLSDSVQKLKEYLSQKFGNSSDTFILSLDGETLSNNATVDQFGVVGGSSIELQ
. ||.|..||| ...| | . | . | ..|  | .. |. . ..  ||...| 
epsdtvselKekieekegipvdqqrLiysGkvLeDdrtlsdyniqdgstlhlv
Rad60-SLD Ubiquitin-2 like Rad60 SUMO-like 45-93 2.8e-08 21.8 Pfam-A 21-70 (72) alignment 
Range on Protein: 45-93
Range on HMM: 21-70/72.0
DSVQKLKEYLSQKFGNSS-DTFILSLDGETLSNNATVDQFGVVGGSSIEL
. ..||.|....| | .. ..  |  ||| |..|.||.. ..  |. |..
ttlskLieayrkkkgipeeqkvrLiFDGerLdpndtvedldiedgdtidv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 217-426 1.2e-78 258.8 In-house 171-301 (301) alignment 
Range on Protein: 217-426
Range on HMM: 171-301/301.0
NqtgcyitsvtdkikipgpyetadeyhgkilkkiiilqshwrrwlatkyvnavreeklmrelwereealrkqrerearrKAEFERRMNPRTKKdFDLLYH
|                                                                              .. .||... ...|       
n..............................................................................ngyierkfkvksdk.sswdvl

ALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
.|..||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
qlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

YLQMNETYGN
|||.|.||.|
ylqlnstyan
0049772 (Phosphotyrosine protein) phosphatases II 231-422 9.6e-13 44.0 In-house 122-284 (314) alignment 
Range on Protein: 231-422
Range on HMM: 122-284/314.0
KIPGP---------------------YETADEYHgkilkkiiilqshwrrwlatKYVNAVREEKLMrelwereealrkqrerearrkaefERRMNPRTKK
 ....                     . ..|...                     . .| . | |                         |.  .|   .
rdivmsrdevladelsrLdaAlgKtpllildgng....................neptaadlellk........................eelydpelfe

DFDLLYHALEMTDWPQDgVVREPHTVLQVIDDVihrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTL
.  . |. . ..|. ..   .    .|..|...        ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|
rlgikylripvpDgsap.lledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieql

EQYTSIYDVIDTYLQMNE
|||  |....  ||.. .
eqyefilealleylkflk
IQ IQ calmodulin-binding motif 248-265 4.1e-07 18.8 Pfam-A 2-19 (21) alignment 
Range on Protein: 248-265
Range on HMM: 2-19/21.0
KKIIILQSHWRRWLATKY
| .|..|..||..|| |.
kaaikIQaawRgylaRkr
subfamily_PTPN23_pd Subfamily PTPN23 291-416 4.1e-15 50.4 In-house 150-278 (288) alignment 
Range on Protein: 291-416
Range on HMM: 150-278/288.0
REARRKAEFERRMNPRTKKDFDLLYHAlEMTDWPQDGVVREPHTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDV
||.    | . ... . ..    . |  ..| ||. ||   |.|.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|.
retethvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldi

FQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 || . .|. .   | . ||.   |... .
iqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 295-419 6.6e-21 69.6 In-house 162-269 (274) alignment 
Range on Protein: 295-419
Range on HMM: 162-269/274.0
RkaeferrmnprtkkdfdlLYHALeMTDWPQDGVVREPHTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKA
.                  ..| .  ||||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  
s..................vkhyw.ytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcn

VRRSKPGAVTTLEQYTSIYDVIDTYLQ
.|  . | | | |||  |. ..  ||.
lrldrGGmvqtseqyelihralclylk
0051082 (Phosphotyrosine protein) phosphatases II 298-413 3.1e-14 48.3 In-house 43-148 (151) alignment 
Range on Protein: 298-413
Range on HMM: 43-148/151.0
EFERRMNPRTKKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSK
|.|| ..|.  .. .. .. . ..|||  |.   ...||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. 
eeergycpeylpelgievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

PGAVTTLEQYTSIYDV
||.|.. .|.  .. .
pgvvqpnqqflfqlfa
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 300-423 9.7e-21 68.9 In-house 161-282 (315) alignment 
Range on Protein: 300-423
Range on HMM: 161-282/315.0
ERRMNPRTKKDFDLLyHALEMTDWPQDGVVREPHTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPG
 |..  |  ..   .    ..|.||. || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .| 
arklvtrkseesrtv.tqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpy

AVTTLEQYTSIYDVIDTYLQMNET
 | | |.|. |||..  .|.  .|
lvqteeeyafiydavledllwrnt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 301-424 2.6e-37 123.3 In-house 164-289 (290) alignment 
Range on Protein: 301-424
Range on HMM: 164-289/290.0
RR--MNPRTKKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKP
|.  .. .....     . ...| |...| | .|.|.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||
rklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkp

GAVTTLEQYTSIYDVIDTYLQMNETY
| |.| .||  |.... |||.  |||
gsvqtvqqyqgifqivltyldsfety
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 301-414 3.9e-08 27.3 In-house 156-265 (281) alignment 
Range on Protein: 301-414
Range on HMM: 156-265/281.0
RRMNPRTKKDFDLLYHALeMTDWPQDGVVREPHTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KP
 |.|   . .  |. | |   .||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . . 
trlnlsyegetrlithwl.wkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgra

GAVTTLEQYTSIYDVI
 .| ||.||  |. |.
asvqtlqqymliwkvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 304-411 1.2e-12 42.0 In-house 179-281 (302) alignment 
Range on Protein: 304-411
Range on HMM: 179-281/302.0
NPRTKKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
| ..||.     . |  . ||. |  .|..| |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| .
nekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd

LEQYTSIY
 .| . . 
eqqliyll
0044763 (Phosphotyrosine protein) phosphatases II 304-422 4e-12 41.6 In-house 67-175 (178) alignment 
Range on Protein: 304-422
Range on HMM: 67-175/178.0
NPRTKKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQkiggGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTT
.|   ..... |. . . |..   . .  . ... |........    |||.||||  |.|||. .   . ...    |. ..... . ||. .| .|..
dpywpeeagiqylhipipDhgvpdllehflefvefieealdekg....gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

LEQYTSIYDVIDTYLQMNE
 .|.  .|..   .|....
pgqlrqLyefelrllkesd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 305-416 3e-17 57.6 In-house 167-277 (288) alignment 
Range on Protein: 305-416
Range on HMM: 167-277/288.0
PRTKKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTL
   ||  .|  . .. . ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||
llekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtl

EQYTSIYDVIDT
.||  ||.|. .
kqYefiyevlls
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 306-416 1.9e-13 44.7 In-house 169-277 (439) alignment 
Range on Protein: 306-416
Range on HMM: 169-277/439.0
RTKKDFDLLyhALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLE
.|.|.  .|   .  . ||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| 
ttekertvl..qfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc

QYTSIYDVIDT
||  ||. .  
qyvfiynavle
0036282 (Phosphotyrosine protein) phosphatases II 307-412 1.6e-16 55.9 In-house 61-164 (174) alignment 
Range on Protein: 307-412
Range on HMM: 61-164/174.0
TKKDFDLLYHALEMTDWPQDGVVREPHtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQ
...|.  | . .  . || .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YTSIYD
|  .|.
yrflyy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 308-424 5.3e-30 99.4 In-house 132-248 (250) alignment 
Range on Protein: 308-424
Range on HMM: 132-248/250.0
KKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
||  . .   |. . ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..||||
kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqy

TSIYDVIDTYLQMNETY
 ..| .|  .|.  | |
vfvyeiilkaldsvedy
0051299 (Phosphotyrosine protein) phosphatases II 308-418 1.9e-25 85.4 In-house 177-286 (288) alignment 
Range on Protein: 308-418
Range on HMM: 177-286/288.0
KKDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
.... . .. . .|.|| .||   |  .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy

TSIYDVIDTYL
  .|...  ||
rfvyealleyl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 308-414 2.3e-15 51.4 In-house 129-235 (237) alignment 
Range on Protein: 308-414
Range on HMM: 129-235/237.0
KKDFDLLyHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
.|.  |. |  ..| ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .|
lkevrli.hqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

YTSIYDVI
|  |...|
yvfihqti
0039614 (Phosphotyrosine protein) phosphatases II 309-422 6e-24 80.5 In-house 179-293 (297) alignment 
Range on Protein: 309-422
Range on HMM: 179-293/297.0
KDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
..  . .. .  |.|| .||   . ..|.... | .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

TSIYDVIDTYLQMNE
  .||..  .|. . 
rflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 309-417 5.2e-23 77.7 In-house 191-303 (307) alignment 
Range on Protein: 309-417
Range on HMM: 191-303/307.0
KDFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTL
... .  . . .|.|| .||   . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

EQYTSIYDVIDTY
|||  .|...  .
eqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 310-417 1.6e-21 72.3 In-house 135-242 (245) alignment 
Range on Protein: 310-417
Range on HMM: 135-242/245.0
DFDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTS
|. .  . .  ..|| .||   . ..|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  
desrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrf

IYDVIDTY
.|...  .
lyeallel
subfamily_PTPRG_pd Subfamily PTPRG 310-423 8.8e-21 68.7 In-house 180-292 (563) alignment 
Range on Protein: 310-423
Range on HMM: 180-292/563.0
DFDLLYHALEMTDWPQDGVVREPHTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTS
| ..|    ..|.||. ||   .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. 
dteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif

IYDVIDTYLQMNET
..|..   .. .||
lhdalleaiasket
0051429 (Phosphotyrosine protein) phosphatases II 310-425 1.4e-16 56.5 In-house 117-248 (272) alignment 
Range on Protein: 310-425
Range on HMM: 117-248/272.0
DFDLLYHALEMTDWPQDGVVREPhtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VFQVTKAVRRSKPGAV
.  . .. | .|||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        .... . .|.  ||||
gearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgav

TTLEQYTSIYDVIDTYLQ----------------MNETYG
 | |||  .|...  .|                 ..|.||
qteeqylflyeallellrsllsvraeyllaaldaideeyG
0041856 (Phosphotyrosine protein) phosphatases II 310-421 4.7e-15 51.1 In-house 77-174 (182) alignment 
Range on Protein: 310-421
Range on HMM: 77-174/182.0
DFDLLYHALEMTDWPQDGvvrePHTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTS
.  . |. | . |..       ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  
rlgiqylylpwpDhgvpd....ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyff

IYDVIDTYLQMN
.....  .|. .
lqlallellllk
0046845 (Phosphotyrosine protein) phosphatases II 311-426 3.2e-26 87.8 In-house 163-282 (284) alignment 
Range on Protein: 311-426
Range on HMM: 163-282/284.0
FDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQ
. .  . . .|.|| .||  .|  .|. ...| . ...  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.||||
esrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleq

YTSIYDVIDTYLQMNETYGN
|  .|...  ||..  |. .
yrfvyealleylklkltlle
DSPc_SM00195 311-418 3e-24 81.1 In-house 156-262 (263) alignment 
Range on Protein: 311-418
Range on HMM: 156-262/263.0
FDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 .   . .....||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. |
etrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

YDVIDTYL
|..|  |.
yeaileyi
PTPc_SM00194 311-418 3e-24 81.1 In-house 156-262 (263) alignment 
Range on Protein: 311-418
Range on HMM: 156-262/263.0
FDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 .   . .....||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. |
etrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

YDVIDTYL
|..|  |.
yeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 311-417 8.3e-23 76.7 In-house 171-276 (278) alignment 
Range on Protein: 311-417
Range on HMM: 171-276/278.0
FDLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
. .  . .  ..|| .||   . ..|. . .|.....   .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .
esrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl

YDVIDTY
|...  |
yealley
subfamily_PTPRA_pd Subfamily PTPRA 312-419 9.7e-25 82.1 In-house 190-296 (330) alignment 
Range on Protein: 312-419
Range on HMM: 190-296/330.0
DLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
  | . . .| ||. ||  ||  .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. ||
srlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiy

DVIDTYLQ
 |.  |  
kvlleyyl
0047943 (Phosphotyrosine protein) phosphatases II 312-418 1.2e-24 82.7 In-house 165-272 (273) alignment 
Range on Protein: 312-418
Range on HMM: 165-272/273.0
DLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 . .. . .|.|| .||   .  .|. |..| . .... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .
srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

YDVIDTYL
|...  ||
yealleyl
0040439 (Phosphotyrosine protein) phosphatases II 312-417 1.9e-23 78.8 In-house 139-245 (249) alignment 
Range on Protein: 312-417
Range on HMM: 139-245/249.0
DLLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
.. .. . .|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . ||| . |. ||.... | .|. .||||...|||  .
srtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

YDVIDTY
|...  .
yeallel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 313-427 1.1e-34 114.8 In-house 173-287 (287) alignment 
Range on Protein: 313-427
Range on HMM: 173-287/287.0
LLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.  .  ..|.|.. | | || |.| ||.. .. |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|
qqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfind

VIDTYLQMNETYGNF
.. .||.  ||| .|
ivleyldsfetysdf
Y_phosphatase Protein-tyrosine phosphatase 313-414 2.1e-25 84.9 Pfam-A 133-233 (235) alignment 
Range on Protein: 313-414
Range on HMM: 133-233/235.0
LLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
   . | .|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|.
revkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk

VI
.|
ai
Y_phosphatase Protein-tyrosine phosphatase 313-414 2.1e-25 84.9 In-house 133-233 (235) alignment 
Range on Protein: 313-414
Range on HMM: 133-233/235.0
LLYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
   . | .|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|.
revkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk

VI
.|
ai
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 313-423 9.4e-21 69.2 In-house 177-289 (297) alignment 
Range on Protein: 313-423
Range on HMM: 177-289/297.0
LLYHALEMTDWPQDGVVR--EPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 . .  . ..||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .
rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

YDVIDTYLQMNET
| ..  .|  ..|
yvavleallsedt
0045098 (Phosphotyrosine protein) phosphatases II 313-422 1.9e-20 68.8 In-house 154-276 (278) alignment 
Range on Protein: 313-422
Range on HMM: 154-276/278.0
LLYHALEMTDWPQDGVVREP--HTVLQVIDDVIHRQQK------------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKP
.  . | .. ||  ||  .|    .|.... . .....             .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|
rgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRp

G-AVTTLEQYTSIYDVIDTYLQMNE
| ||..||||  .|...  .|....
glavqnleqyrflyefllelllrgk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 313-414 1.5e-19 65.0 In-house 162-262 (283) alignment 
Range on Protein: 313-414
Range on HMM: 162-262/283.0
LLYHALEMTDWpqdgVVREPHTVLQ---VIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTS
||     . ||    .  .. ...     .. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  
lllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqykl

IYDVI
.....
vhelv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 313-417 1.8e-10 35.0 In-house 184-282 (290) alignment 
Range on Protein: 313-417
Range on HMM: 184-282/290.0
LLYHaLEMTDWPQDGVVREPHTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 |.| |..  ||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . 
klkh.lkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalv

DVIDTY
...  .
eilldl
subfamily_PTPN12_pd Subfamily PTPN12 314-419 8.7e-18 59.2 In-house 171-278 (290) alignment 
Range on Protein: 314-419
Range on HMM: 171-278/290.0
LYHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSI
  . .. |.||  || . ....|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .
kvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelv

YDVIDTYLQ
|  .  ..|
ykavaelvq
subfamily_PTPN3_pd Subfamily PTPN3 314-414 3.5e-13 44.1 In-house 172-271 (280) alignment 
Range on Protein: 314-414
Range on HMM: 172-271/280.0
LYHALEMTDWPQDGVVREPHTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
  . |  ..||. ||  ... .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . 
kilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea

I
|
i
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 314-420 1.7e-09 32.2 In-house 172-273 (288) alignment 
Range on Protein: 314-420
Range on HMM: 172-273/288.0
LYHALEMTDWPQDGVVREPHTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.   | . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  ||  .. .
ivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrc

IDTYLQM
.  .| .
vleelll
subfamily_DSP1_pd Subfamily DSP1 314-408 5.8e-06 20.5 In-house 63-153 (163) alignment 
Range on Protein: 314-408
Range on HMM: 63-153/163.0
LYHALEMTDWPQDGVVREPHTVLQVIDDVIHRqqkigGGPVVVHCSDTVSRSGVYCSVSI-GLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYT
 |. |.. | |.. .    ..|.. ||.|..      .| | .||   .|||   | . .   .... |   |  .  ... .   | |  | .| 
eYkklkleDspkadislvfeeviefidevkkk.....nGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnye
0050432 (Phosphotyrosine protein) phosphatases II 315-424 2.7e-26 88.1 In-house 199-305 (308) alignment 
Range on Protein: 315-424
Range on HMM: 199-305/308.0
YHALEMTDWPQDGVVREPHTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.. . .|.|| .||  .|  .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|...
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

DTYLQMNETY
  ||.  .|.
leylklkltk
0040438 (Phosphotyrosine protein) phosphatases II 315-425 2.1e-24 81.8 In-house 174-283 (317) alignment 
Range on Protein: 315-425
Range on HMM: 174-283/317.0
YHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 . . .|.|| .||   | ..|. .. | . ..  . ||||.||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.
vthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

IDTYLQMNETYG
.  ||. ..|. 
lleylkrkltle
0037934 (Phosphotyrosine protein) phosphatases II 315-417 2.8e-18 61.8 In-house 135-241 (243) alignment 
Range on Protein: 315-417
Range on HMM: 135-241/243.0
YHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQ
 . .  . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |...   | ||.... | .|. .|| ||.|..|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq

YTSIYDVIDTY
|  .|...  .
yrflyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 315-418 1.9e-17 58.4 In-house 180-288 (325) alignment 
Range on Protein: 315-418
Range on HMM: 180-288/325.0
YHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTS
 . ...  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. 
vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyil

IYDVIDTYL
||. .  ..
iyealveay
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 315-420 1.9e-15 51.7 In-house 172-278 (281) alignment 
Range on Protein: 315-420
Range on HMM: 172-278/281.0
YHALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 . |. | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| .
veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvyka

IDTYLQM
.  .|. 
vldaldk
0036941 (Phosphotyrosine protein) phosphatases II 316-423 2.6e-25 84.7 In-house 171-282 (297) alignment 
Range on Protein: 316-423
Range on HMM: 171-282/297.0
HALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
. . .|.|| .||   | ..|. |. | ...... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

DVIDTYLQMNET
...  .|. ..|
eallellkkklt
subfamily_PTPRK_pd Subfamily PTPRK 316-414 7.1e-23 75.9 In-house 176-273 (314) alignment 
Range on Protein: 316-414
Range on HMM: 176-273/314.0
HALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. .. . ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
rqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN6_pd Subfamily PTPN6 316-423 4.8e-21 70.0 In-house 189-302 (306) alignment 
Range on Protein: 316-423
Range on HMM: 189-302/306.0
HALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTS
. .. ..||. || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  
fqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykf

IYDVIDTYLQMNET
.| .| .|.. ...
vykaikkyietkkk
subfamily_PTPRB_pd Subfamily PTPRB 316-421 4.6e-17 57.0 In-house 182-288 (293) alignment 
Range on Protein: 316-421
Range on HMM: 182-288/293.0
HALEMTDWPQDGVVREPHTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. .. | ||. ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....
rqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcv

DTYLQMN
 ..|. .
ldllrkk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 316-422 1.9e-09 31.7 In-house 171-281 (287) alignment 
Range on Protein: 316-422
Range on HMM: 171-281/287.0
HALEMTDWPQDGVVREP----HTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
. |.. .||....          ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|
kqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrlly

DVIDTYLQMNE
. . || . | 
ealvtyyktnp
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 316-418 1.4e-06 22.2 In-house 191-289 (305) alignment 
Range on Protein: 316-418
Range on HMM: 191-289/305.0
HALEMTDWPQDGVVREPHTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGLEQCKA-EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
  |. |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |. |.
rhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm

DTYL
  |.
lnyf
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 317-423 2.5e-45 149.9 In-house 182-288 (305) alignment 
Range on Protein: 317-423
Range on HMM: 182-288/305.0
ALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 ...||||..||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| 
qyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde

YLQMNET
...  .|
litcgdt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 317-424 2.8e-30 100.6 In-house 189-296 (298) alignment 
Range on Protein: 317-424
Range on HMM: 189-296/298.0
ALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 |..| ||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  
qlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle

YLQMNETY
.|.  ...
aldsfnde
PTPc_DSPc_SM00012 317-414 1.1e-23 78.8 In-house 4-103 (105) alignment 
Range on Protein: 317-414
Range on HMM: 4-103/105.0
ALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ...|.||. || .|.. .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|...
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_CG7180_pd Subfamily CG7180 317-423 1.2e-22 74.9 In-house 184-295 (296) alignment 
Range on Protein: 317-423
Range on HMM: 184-295/296.0
ALEMTDWPQ-DGVVREPHTVLQVIDDVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 ...| |.  | |     ......  |   ..|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|  ||
lfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiY

DVIDTYLQMNET
||.  .. .| .
dvlleavlcnkd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 317-418 1.2e-20 68.7 In-house 179-280 (315) alignment 
Range on Protein: 317-418
Range on HMM: 179-280/315.0
ALEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI-D
 |..| ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||.. .
qlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

TYL
|..
tfv
subfamily_PTPN13_pd Subfamily PTPN13 317-420 6.4e-16 53.4 In-house 170-271 (273) alignment 
Range on Protein: 317-420
Range on HMM: 170-271/273.0
ALEMTDWPQDGVVREPHTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 |....||  || ...  .||..  | . |.    ||.|||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .| .
hlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

YLQM
 |..
vlks
subfamily_PTPN14_pd Subfamily PTPN14 317-419 6e-14 46.7 In-house 187-297 (300) alignment 
Range on Protein: 317-419
Range on HMM: 187-297/300.0
ALEMTDWPQDGVVREPHTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYT
 |  ||||..|| ..... |. ...|    .  ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||.
hlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYk

SIYDVIDTYLQ
 .|.|. .||.
fvYkvlikylk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 318-424 2.8e-28 93.9 In-house 180-286 (318) alignment 
Range on Protein: 318-424
Range on HMM: 180-286/318.0
LEMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
 ..|.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .
yhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea

LQMNETY
|.  .|.
lasgdte
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 318-420 6.5e-18 59.7 In-house 157-266 (270) alignment 
Range on Protein: 318-420
Range on HMM: 157-266/270.0
LEMTDWPQDGVVREPH------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
  ...||..||.||.        .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .
fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl

YDVIDTYLQM
| .. .| ..
ykavveyaer
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 318-411 3.7e-14 47.4 In-house 141-233 (239) alignment 
Range on Protein: 318-411
Range on HMM: 141-233/239.0
LEMTDWPQDGVVREPHTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
  .| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
yhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 318-411 4e-14 47.3 In-house 142-234 (239) alignment 
Range on Protein: 318-411
Range on HMM: 142-234/239.0
LEMTDWPQDGVVREPHTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
  .| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
yhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0043147 (Phosphotyrosine protein) phosphatases II 318-412 5.2e-14 47.8 In-house 68-155 (172) alignment 
Range on Protein: 318-412
Range on HMM: 68-155/172.0
LEMTDWPQDGVVrEPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.  . ||  ||   .  .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|.
ylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
0048179 (Phosphotyrosine protein) phosphatases II 318-412 1.1e-11 40.2 In-house 52-139 (144) alignment 
Range on Protein: 318-412
Range on HMM: 52-139/144.0
LEMTDWPQDGVVREPHTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.  ..||  ||   .. .|.... . . ..   ||||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
ylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN1_pd Subfamily PTPN1 318-411 2.5e-10 34.5 In-house 167-264 (290) alignment 
Range on Protein: 318-411
Range on HMM: 167-264/290.0
LEMTDWPQDGVVREPHTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   | ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
fhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 318-425 1.7e-08 28.8 In-house 181-286 (307) alignment 
Range on Protein: 318-425
Range on HMM: 181-286/307.0
LEMTDWPQDGVVREPHTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
|. ..||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  
lqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

YL--QMNETYG
|.  .  ||| 
yflelyketye
subfamily_PTPRD_pd Subfamily PTPRD 319-423 8.6e-29 95.6 In-house 183-286 (564) alignment 
Range on Protein: 319-423
Range on HMM: 183-286/564.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
  |.||. ||  .. ..|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|
hFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

QMNET
.. .|
acgnt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 319-423 2.7e-28 94.0 In-house 184-288 (319) alignment 
Range on Protein: 319-423
Range on HMM: 184-288/319.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
  |.||...| ..  ..|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  ..
qyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav

QMNET
.. .|
eagdt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 319-423 3.4e-20 66.6 In-house 178-281 (515) alignment 
Range on Protein: 319-423
Range on HMM: 178-281/515.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
..|.||. || ..  ..|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .|
hfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

QMNET
   .|
lwrnt
subfamily_Ptp69D_pd Subfamily Ptp69D 319-423 4.1e-20 67.1 In-house 188-291 (307) alignment 
Range on Protein: 319-423
Range on HMM: 188-291/307.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
. | |.   | . ....|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .  | 
hytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

QMNET
.. .|
sygdt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 319-417 7.8e-16 52.4 In-house 95-193 (440) alignment 
Range on Protein: 319-417
Range on HMM: 95-193/440.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
 .  ||. || .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . ...| ..|  | | |||. .....   
hyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavleg
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 319-416 1.4e-14 48.3 In-house 138-234 (392) alignment 
Range on Protein: 319-416
Range on HMM: 138-234/392.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 .|.||...| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | |||. ||  .  
hftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_PTPN9_pd Subfamily PTPN9 319-418 3.4e-13 44.3 In-house 179-290 (297) alignment 
Range on Protein: 319-418
Range on HMM: 179-290/297.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
 .. ||  || .. ...|.|.. | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | ||
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq

YTSIYDVIDTYL
|.  |  .  | 
yefcylavleya
0048076 (Phosphotyrosine protein) phosphatases II 319-415 1.8e-12 42.6 In-house 51-140 (145) alignment 
Range on Protein: 319-415
Range on HMM: 51-140/145.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
  ..||  ||   . ..|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |..... . ||.  ||||.. .|.  .|... 
lylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 319-415 9.2e-10 33.1 In-house 164-256 (290) alignment 
Range on Protein: 319-415
Range on HMM: 164-256/290.0
EMTDWPQDGVVREPHTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 . .| .  | ... |.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. .... .  .| 
llkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 319-413 2e-07 24.9 In-house 196-285 (310) alignment 
Range on Protein: 319-413
Range on HMM: 196-285/310.0
EMTDWPQDGVVRE-PHTVLQVIddviHrqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
   .||. ||  |  ||| | .        ..  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  |
kwpnwpdrgvpdekchtvpqrl....l..aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 320-413 4.9e-16 53.9 In-house 192-286 (319) alignment 
Range on Protein: 320-413
Range on HMM: 192-286/319.0
MTDWPQDGVVREPHTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.  ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 320-413 6.2e-16 53.7 In-house 156-250 (284) alignment 
Range on Protein: 320-413
Range on HMM: 156-250/284.0
MTDWPQDGVVREPHTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.  ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
0046846 (Phosphotyrosine protein) phosphatases II 320-418 4.4e-13 44.8 In-house 81-173 (176) alignment 
Range on Protein: 320-418
Range on HMM: 81-173/176.0
MTDWPQDGVVREpHTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDTYL
 ..||  ||      .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|...  .|
hlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 320-419 9.5e-08 26.1 In-house 193-288 (305) alignment 
Range on Protein: 320-419
Range on HMM: 193-288/305.0
MTDWPQDGVVREPHTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
  |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  ...||  |.
widwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

Q
.
r
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 320-420 1.3e-07 25.4 In-house 188-287 (302) alignment 
Range on Protein: 320-420
Range on HMM: 188-287/302.0
MTDWPQDGVVREPHTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
.| |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|..
ltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

M
 
k
subfamily_PTPRN_pd Subfamily PTPRN 322-413 5.6e-09 30.1 In-house 196-287 (297) alignment 
Range on Protein: 322-413
Range on HMM: 196-287/297.0
DWPQDGVVREPHTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 ||. ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. .
swpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
0049260 (Phosphotyrosine protein) phosphatases II 323-412 1.2e-12 43.3 In-house 62-144 (152) alignment 
Range on Protein: 323-412
Range on HMM: 62-144/152.0
WPqDGVVREPHTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|| |. | . . .|. . ..|.. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
wp.DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 344-418 6.2e-15 49.9 In-house 185-259 (267) alignment 
Range on Protein: 344-418
Range on HMM: 185-259/267.0
HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
. | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....  | 
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_CG42327_pd Subfamily CG42327 350-417 3.5e-12 40.6 In-house 246-314 (319) alignment 
Range on Protein: 350-417
Range on HMM: 246-314/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 350-413 1.3e-10 35.7 In-house 134-199 (199) alignment 
Range on Protein: 350-413
Range on HMM: 134-199/199.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
   ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 350-413 1.3e-10 35.8 In-house 133-198 (198) alignment 
Range on Protein: 350-413
Range on HMM: 133-198/198.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
   ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 353-414 2.4e-08 28.2 In-house 230-291 (297) alignment 
Range on Protein: 353-414
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 355-415 5.2e-08 27.2 In-house 2-62 (69) alignment 
Range on Protein: 355-415
Range on HMM: 2-62/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 355-417 1.8e-07 25.4 In-house 1-63 (69) alignment 
Range on Protein: 355-417
Range on HMM: 1-63/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .   
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea