Gene PTPRD-63 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP121_AA protein Get Run
AqueP121_AA_1-155 phosphatase_domain Get Run
AqueP121_AA_178-207 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-139 9.8e-51 167.7 In-house 129-269 (305) alignment 
Range on Protein: 1-139
Range on HMM: 129-269/305.0
ECCYQYWRESDTI--SFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
..|.||| || |    |||. |.   .|  ..||||||.|  ...|. |  |.|.|.|.|| .|| ... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|.||...|.||||..|.|.|||||.|.| .|......|.||
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-152 1.7e-45 150.2 In-house 126-277 (287) alignment 
Range on Protein: 1-152
Range on HMM: 126-277/287.0
ECCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
| ||||| |......||| .. |  .  .|||||||... ......   |.|.|.|||.  | . ||.|.| ||.. .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
...|.. .....|| |||.||||| || |  |||.| |    | .. .....
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-155 7.5e-77 253.0 In-house 126-295 (301) alignment 
Range on Protein: 2-155
Range on HMM: 126-295/301.0
CCYQYWRESDTISFGEYFVKCLLSKDC-------------------NGYIERKLHIRSDKndsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ
.|.|||..|.. |  .......|....                   |||||||....|||   |||||.|.|||.||.|||.||||||||||||||||||
kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIVL
||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||| .   .. .. |.. |
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-152 1.2e-49 163.8 In-house 132-282 (290) alignment 
Range on Protein: 2-152
Range on HMM: 132-282/290.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |.||| .||| ..||. .| |  . .|.||||||........ ..  |.|.|.|||. .| . .| |.|.||  ... | | | ...||||||||.||.
kCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsa

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
|.|.. .....|| |||.||||| || |  ||| |.| ....... ...  
vfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
0046845 (Phosphotyrosine protein) phosphatases II 2-155 3.3e-32 107.4 In-house 118-276 (284) alignment 
Range on Protein: 2-155
Range on HMM: 118-276/284.0
CCYQYWRESD-TISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSR
 |.||| ... .. .|...|..|  . ...|. |.| ..  . .. |  | .|..|.|| .||  .|. .|. ...| . ...  ||||.|||||. |.|
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

SGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIVL
.|... . ..||| ..||   .|||... | .|. .||.|.||  ..   ....... |
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0051299 (Phosphotyrosine protein) phosphatases II 2-150 4.7e-32 107.0 In-house 133-283 (288) alignment 
Range on Protein: 2-150
Range on HMM: 133-283/288.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDK---NDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVS
 |.||| ..... .|...|..|  . ...|. |.|...  .    |. |  | .|..|||| .||   |. .|. . .|.. ..  ||||||||||. |.
kcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
|.|... . ..||| ..||.|||... | .|. .||.|.|.  ..   ....
RtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0039614 (Phosphotyrosine protein) phosphatases II 2-152 4.6e-30 100.5 In-house 141-288 (297) alignment 
Range on Protein: 2-152
Range on HMM: 141-288/297.0
CCYQYWRESDTiSFGEYFVKCLLSKDCNGYIERKLHIRSdknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRS
.|.||| |. .  .|...|..|  . ..||. |.|...    .. |  | .||.|.|| .||   ....|.... | .....  .||||.||||. |.|.
kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
|...   ..|||.. || |||... | .|. .||||.|.  ..  .......
GtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0045450 (Phosphotyrosine protein) phosphatases II 2-150 5.8e-29 97.2 In-house 148-301 (307) alignment 
Range on Protein: 2-150
Range on HMM: 148-301/307.0
CCYQYWRES-DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSR
 |.||| .. ... .|...|..|  . ..||. |.|..   . .. |  | .|. |.|| .||   . ..|. |. | . ...  .||||.||||. |.|
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

SGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.|...   ..|.| ..||.   ||.... | .|. .||||...  ..  .....
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-138 2.9e-26 87.3 In-house 132-269 (297) alignment 
Range on Protein: 2-138
Range on HMM: 132-269/297.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSsWDVVQFQVTNWPTDGVIR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
 | .|| .. . .||.  |. |  ....|.|.|.|... .|. .    | |.| ..||.. | |  . ...|..|..| .  ..   ||..|||.  | |
kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
 ||....   . . | |  ||.|.. | .|...|  | |
tgvlltidsvvaeakrekevdifglvkklrqerpylvqt
subfamily_PTPRA_pd Subfamily PTPRA 2-142 3.5e-26 86.9 In-house 142-284 (330) alignment 
Range on Protein: 2-142
Range on HMM: 142-284/330.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIR---SDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVS
 |.||| .  ....|.  |.   .. .. |  ||. ..     ... .|  | ||  | ||  ||  ||. .|...  | . .|. .| |.|||||  | 
kcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvG

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCI
|.| .. ..  ||. |||..||||.. |..|  .|  | |.   
rtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy
subfamily_PTPN6_pd Subfamily PTPN6 2-149 1.1e-25 85.3 In-house 139-293 (306) alignment 
Range on Protein: 2-149
Range on HMM: 139-293/306.0
CCYQYWRES-DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTV
 |..|| .. .. ..|.. |... .|. . || |.|..   |..... .|.|.. ..||  || ..| .||. ..|| ..|...     ||.|||||. .
kCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGi

SRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
 | | .  . | |.. . .|.   .|. .. ||||. . | | |  . |.. ...
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-144 5.4e-25 82.8 In-house 116-257 (283) alignment 
Range on Protein: 2-144
Range on HMM: 116-257/283.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWpTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 | ||| .  .. .||. |        | .| ..| .| .    |.  .  .|| .| ..     .   |  .. ||  |..   ||.||||| .. |..
kCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKI
|....| .... ..| |||||.| | .|  ...|| ||   |.
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqykl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-152 7.2e-23 76.4 In-house 139-290 (319) alignment 
Range on Protein: 2-152
Range on HMM: 139-290/319.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRS
 | |||     |  ... ||  . .... |. |....  | .     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |.
kcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
|||  . . |.. | |  |||... . .|. ..  |  ||  |.. . ..  
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-158 7.8e-23 76.4 In-house 103-259 (284) alignment 
Range on Protein: 2-158
Range on HMM: 103-259/284.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRS
 | |||     |  ... ||  . .... |. |....  | .     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |.
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMiVLFRI
|||  . . |.. | |  |||... . .|. ..  |  ||  |.. . ..    ||  
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee.hlfgh
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-149 1.6e-21 71.7 In-house 131-284 (325) alignment 
Range on Protein: 2-149
Range on HMM: 131-284/325.0
CCYQYWRES--DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCS
 | .|| .   ..  ||   ||    ..   |. |.|...  |.   .  | |||.  |.  || . | |.. ... | . ....     . .|..||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
. | |.||. |.  ||..   |  ||.|.. | .|. .|  | |     ..   .
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-138 3.7e-17 57.3 In-house 86-224 (237) alignment 
Range on Protein: 2-138
Range on HMM: 86-224/237.0
CCYQYWRESDT-ISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSR
 |..|| ..|   ..| . |     ..   |  | | .    .      . |.| | ||  || ..  ..|.   ..|.| ...   || ..|||  | |
kchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.|..  .   | |.| . |||...  .|.   .|  . |
tgiflvidamlrqakekkvvdiynyvysieedrpyiiqt
0036282 (Phosphotyrosine protein) phosphatases II 2-139 2.4e-15 52.1 In-house 53-156 (174) alignment 
Range on Protein: 2-139
Range on HMM: 53-156/174.0
CCYQYWREsdtisfgeyfvkcllskdcngyierklhirsdKNDSSSWDVVQFQVTNWPTDGVIREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |..|| |                                . .. .  ..|.. ..|| .||   .  .|.... | . ... .||||.||||  |.|.|
kcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

VYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTL
. .   . | . . |..||.... ...|. .||.|.| 
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp
0041856 (Phosphotyrosine protein) phosphatases II 2-149 1.8e-13 46.0 In-house 66-167 (182) alignment 
Range on Protein: 2-149
Range on HMM: 66-167/182.0
CCYQYWResdtisfgeyfvkcllskdcngyierklhirsdknDSSSWDVVQFQVTNWPTDGVIRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSG
....||                                    .     ..|.. ..|| .||   ....|. |..|..      ||||.||||  |.|.|
teelywp...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtg

VYCSVSIALEQckaeGvVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
...   . ...    | |..... | ||. .||.|.|.  . . ....
tlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlal
subfamily_PTPRD_pd Subfamily PTPRD 3-138 6.8e-34 112.4 In-house 133-266 (564) alignment 
Range on Protein: 3-138
Range on HMM: 133-266/564.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIrSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGV
| .|| |..| ..||. |.   ... . |. |.. . ..|..|.|  | ||. |.||  ||  .....|..|..| . . . . ||.|||||  | |.|.
chkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.. ... ||. |.|..||..|. | .|. ..  | |
fividamlerikeektvDiyqyvkalrkqRnamVqt
0050432 (Phosphotyrosine protein) phosphatases II 3-154 2.4e-33 111.2 In-house 150-300 (308) alignment 
Range on Protein: 3-154
Range on HMM: 150-300/308.0
CYQYWRES---DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSR
|.||| ..   ... .| ..|..|  . ...|. |.|...  ...  |  | .|. |||| .||  .|. .|. .. | ...   .|||.|||||. |.|
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIV
.|... . ..||| ..|| ||||.. | .|. .||.|.|.   . ......... 
tGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-143 3.5e-32 106.8 In-house 141-280 (298) alignment 
Range on Protein: 3-143
Range on HMM: 141-280/298.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| .. .  .||  |. | ...   .| |||.. . |.. ..  |.|...|.||  || .. ..||.....|   ||. |  ||.|.||. | ||| 
yhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIK
.. ..  ||. |.| ||||||| | .|...||||.|    .
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-154 3.6e-32 106.7 In-house 133-284 (319) alignment 
Range on Protein: 3-154
Range on HMM: 133-284/319.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| | .  ..|.. |. .  .  ..|| |||...  ...  . .|..|| |.|| ..| .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIV
.. ....||. | |||.|||.. . .|  ..  | .    |..   .. .. 
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0036941 (Phosphotyrosine protein) phosphatases II 3-156 3.8e-32 107.2 In-house 120-280 (297) alignment 
Range on Protein: 3-156
Range on HMM: 120-280/297.0
CYQYWRES--DTISFGEYFVKCLLSKD--CNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTV
|.||| .   ... .|...|..|  .   ...|. |.|..    ... |  | .|..|.|| .||   |...|. |. | ...... .||||.||||. |
caqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSGVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIVLF
.|||... . ..|.| .    || ||.... |..|. .||||.||   . . ..... .  .
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0040438 (Phosphotyrosine protein) phosphatases II 3-157 3.8e-31 104.0 In-house 128-278 (317) alignment 
Range on Protein: 3-157
Range on HMM: 128-278/317.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSG
|.||| . .|. .|...|..|  . ..|.. |.|..  . .|| |  | .|. |.|| .||   |...|. .. | . ..  . ||||.||||. |.|.|
caqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIvlFR
... . ..|||.. || |||... | .|. .||||.|.  .. .........   |
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..kr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3-138 5.7e-31 102.7 In-house 131-265 (318) alignment 
Range on Protein: 3-138
Range on HMM: 131-265/318.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSdKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| .....|.|.  |.   ..... |. |.....  .. ..| .| |...|.||  ||  .. ..|... .| . ||| | ||.|||||  | | ||
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGv

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.. |.| ||. |||..|||||. | .|. ..  | |
fiavdillerikaealvDvfqtvkqlreqrnlmvqt
0047943 (Phosphotyrosine protein) phosphatases II 3-151 5.7e-31 103.4 In-house 119-270 (273) alignment 
Range on Protein: 3-151
Range on HMM: 119-270/273.0
CYQYWRESD---TISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVS
|.||| ..    .. .|...|..|  . ...|. |.| ... ...  |  | .|..|.|| .||   .  .|. |..| . .... ..||||||||. |.
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIM
|.|... . ..|.| ..|| |||... | .|. .||.|.|.  .. .......
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3-150 6.4e-31 102.4 In-house 93-239 (250) alignment 
Range on Protein: 3-150
Range on HMM: 93-239/250.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. |||    .  .|.  |. | ..    |. ||| . . |. ...  |.|.. ..||  || .. ..||.....|   ||..| .||.|.||  |.||| 
yhqywPvekaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.. ..  ||. | | |||||.| | .|. .|.||..|     . ....
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil
Y_phosphatase Protein-tyrosine phosphatase 3-147 3.8e-30 100.4 Pfam-A 84-231 (235) alignment 
Range on Protein: 3-147
Range on HMM: 84-231/235.0
CYQYWR--ESDTISFGEYFVKCL-LSK-DCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVS
| |||   |... ..|...|..   .| |...|. |||.....|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |.
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
|.|......|.|||..||. |||.|. |..|...||.|..|   . ...
RtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 3-147 3.8e-30 100.4 In-house 84-231 (235) alignment 
Range on Protein: 3-147
Range on HMM: 84-231/235.0
CYQYWR--ESDTISFGEYFVKCL-LSK-DCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVS
| |||   |... ..|...|..   .| |...|. |||.....|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |.
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
|.|......|.|||..||. |||.|. |..|...||.|..|   . ...
RtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
0043336 (Phosphotyrosine protein) phosphatases II 3-147 9.4e-30 99.4 In-house 130-271 (278) alignment 
Range on Protein: 3-147
Range on HMM: 130-271/278.0
CYQYWReSDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSsWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
|.|||  .... .|...|..|  . ...|. |.|..   ... |   |.... ..|| .||   . ..|. . .|.....   .|||.||||. |.|.|.
caqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
.. . ..||| . || ||.... | .|. .||||.|.  ..   .
fialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0040439 (Phosphotyrosine protein) phosphatases II 3-149 1.7e-29 98.6 In-house 96-242 (249) alignment 
Range on Protein: 3-149
Range on HMM: 96-242/249.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
|.||| ..... .|...|..|  . ...|. |.|..     |..|  | ..|.|.|| .||   . ..|. |. | . ....  ||||.||||. |.|.|
caqywplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
...   ..||| . |. ||.... | .|. .||||...  ..  ....
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
DSPc_SM00195 3-150 3.6e-29 97.3 In-house 111-259 (263) alignment 
Range on Protein: 3-150
Range on HMM: 111-259/263.0
CYQYWRES--DTISFGEYFVKCLLSKDCN-GYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
|..|| |.  ..  ||.. ||.   . ..  .| |.|... ... . . .| |.|..|||  ||  ... ||...  | ......  ||.|||||. |.|
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.|......|.|.....|  ||.|.. |..| ..||.|.||   ........
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 3-150 3.6e-29 97.3 In-house 111-259 (263) alignment 
Range on Protein: 3-150
Range on HMM: 111-259/263.0
CYQYWRES--DTISFGEYFVKCLLSKDCN-GYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
|..|| |.  ..  ||.. ||.   . ..  .| |.|... ... . . .| |.|..|||  ||  ... ||...  | ......  ||.|||||. |.|
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.|......|.|.....|  ||.|.. |..| ..||.|.||   ........
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
0042113 (Phosphotyrosine protein) phosphatases II 3-149 3.2e-28 94.2 In-house 94-239 (245) alignment 
Range on Protein: 3-149
Range on HMM: 94-239/245.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSdKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| ..... .|...|..|  . ...|. |.|..   . |. |  |.... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|.
caqywplgesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
.. . ..||| ..|. |..... | .|. .||||.|.  .. .....
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Ptp69D_pd Subfamily Ptp69D 3-139 2e-27 91.1 In-house 133-272 (307) alignment 
Range on Protein: 3-139
Range on HMM: 133-272/307.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDS----SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVS
| .|| . |.. .|.  ||.  .. .. ||.|.|..   |..|     |  |||.. |.|.   | . .|..|..|. | . ...   .|.|||||  |.
cakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|||.. .... |.|.|||  ||.|...| .|. ..  |. |
rsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl
0037934 (Phosphotyrosine protein) phosphatases II 3-151 2.4e-26 88.2 In-house 90-240 (243) alignment 
Range on Protein: 3-151
Range on HMM: 90-240/243.0
CYQYWResDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSD
|.|||   ... .|...|..| .. ...|. |.|...  . |  .. |.... ..||  ||  .|  .|. .|.|.  ...        .||||.|||| 
caqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

TVSRSGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLVCIKIMMMMMIM
 |.|.|...   . |...   | ||.... | .|. .|| ||.|.  ..  ......
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 3-151 3.7e-26 87.6 In-house 106-270 (278) alignment 
Range on Protein: 3-151
Range on HMM: 106-270/278.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSD---KNDSSSWDVVQFQVTNWPTDGVIREP--RTVLQVIDDVIHRQQK------------IG
|.||| |.... .|...|..|  . .. |. |.|...     ..|  |. | ... ..||  ||  .|  . .|.... . .....             .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLVCIKIMMMMMIM
||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..|  .. .......
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPRK_pd Subfamily PTPRK 3-139 3.3e-25 83.5 In-house 128-263 (314) alignment 
Range on Protein: 3-139
Range on HMM: 128-263/314.0
CYQYWRESDTIsFGEYFVKCLLSKDCNGYIERKLHIRS-DKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSG
|..|| |  .. .|.  |... ..  . .. | . ..   .. .    | ||| ..||. .|  . ...|...  | . |.. . |..|||||    |.|
ClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
... ..| |.  . |||||||.. |..| .|.  | | 
tfiaidivldmieregvvdvfnavktlrsrkvnmvete
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-138 1.3e-24 81.7 In-house 129-262 (315) alignment 
Range on Protein: 3-138
Range on HMM: 129-262/315.0
CYQYWRE--SDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKndsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRS
| ||| .  .|.. ||.. |. |  . . . . ||| .|  .   .|  | ||| |.||  || ..  ..|..| .|    ..    ...||||  | |.
crqywPdrkadsvefGsikvellsleadtdgvarklvtrkse...esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|| .|.   ..| | . .||||.. | .|. .|  | |
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-138 5.1e-24 79.2 In-house 128-261 (515) alignment 
Range on Protein: 3-138
Range on HMM: 128-261/515.0
CYQYWRE--SDTISFGEYFVKCLLSKDCNGYIERKLHIRsdKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRS
| .|| .  .|.. ||.. |. .  . | | | |||..   |.|  |  | ||. |.||  || .. ...|..| .|   ....   |...|||  | | 
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl..kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
||..|.   . . |   .||||.. . .|. .|  | |
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-149 1.5e-22 75.0 In-house 126-272 (281) alignment 
Range on Protein: 3-149
Range on HMM: 126-272/281.0
CYQYWRESD-TISFGEYFVKCLLSKDCNGYIERKLHIrsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
|..|| . . ....|.. || . ... . |||||...  ..... . .|.|.. |.||  ||  ... .|.  ..| . ..|    |.|.|||  | |.|
ChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtG

VYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
.| ..  ......||   .|| .| ...|...   | |.|. . .  ..
tyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
subfamily_PTPRG_pd Subfamily PTPRG 3-138 7e-22 72.3 In-house 133-272 (563) alignment 
Range on Protein: 3-138
Range on HMM: 133-272/563.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRS---DKN-D-SSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTV
| .|| . ... .|.  |.   ..    | .|.| |.    .|. .  .   | |.. |.||  ||   .  ||. .     . .|   ||.|||||  |
cdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.|
grtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-141 2.1e-21 71.3 In-house 132-267 (288) alignment 
Range on Protein: 3-141
Range on HMM: 132-267/288.0
CYQYWRESDT-ISFGEYFVKCLLSKDCNGYIERKLHIRsdkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSG
| .|| ..|.   .|.  |. . ||. . ...||| .     . .  .. |.| . || .|| .  . .|.... |   .|.   ||..||||. | |.|
CeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtg

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVC
.. ..  .... ..| ..||. . . .|....  | ||  
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkq
subfamily_PTPRB_pd Subfamily PTPRB 3-140 1e-20 69.0 In-house 136-272 (293) alignment 
Range on Protein: 3-140
Range on HMM: 136-272/293.0
CYQYWRES-DTISFGEYFVKCLLSKDCNGYIERKLHIRSdknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRS
| .|| .  ... .|.  |. . ... . .. |.|.|.    .... .| |.. | ||  ||  ...|.|. .  | ... ..   .|.|||||  | |.
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLV
|.. ..   |.. . | .||.| .  ..|...   | |  
GtfialdrllqaieeedyvdifgivaelReeRnllvqtek
subfamily_CG7180_pd Subfamily CG7180 3-138 1.3e-20 68.3 In-house 126-275 (296) alignment 
Range on Protein: 3-138
Range on HMM: 126-275/296.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSD------K---NDSSSWDVVQFQVTNWPT-DGVIREPRTVLQVIDDVIHRQQKI----GGGP
. .|| .     .|| ||. . .|       |....         .    .     | .||.| |.  | |     ......  |   ..|.      ||
ypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|||..|| .||||||... ..||. . |. ||||.  | .|||.|. | .
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
subfamily_PTPN3_pd Subfamily PTPN3 3-138 1.4e-20 68.4 In-house 126-260 (280) alignment 
Range on Protein: 3-138
Range on HMM: 126-260/280.0
CYQYWRE-SDTISFGEYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSG
|.||| | .|....||. |||  ..  . |. |.| .. ||. . .  ..|.| ..||  ||  ..  .|.... | .....    |||||||  . |.|
ChqyWPetedeleygefsvkcekedetksyvlrelvlk.dketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|.  . .||    |.  | . .. . .|  .   | |
vlilletalalieaaepvypldivrtmrdqramlvqt
subfamily_PTPN23_pd Subfamily PTPN23 3-149 4.1e-20 66.8 In-house 125-276 (288) alignment 
Range on Protein: 3-149
Range on HMM: 125-276/288.0
CYQYW--RESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTV
. .||  .. .| .||.. | .   .. . ..||.|...  ..|    .|.  |.|.||  ||   | |.||..| | .    .|.    |.|||||  |
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGv

SRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
 |.||.. |  |...  | .|..|. || . .|. .   | .   .| .. ..
gRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3-150 8.6e-20 65.9 In-house 134-276 (315) alignment 
Range on Protein: 3-150
Range on HMM: 134-276/315.0
CYQYWRESdTISFGEYFVKCLLSKDCNGYIERKLhirSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGV
. .|| .   . .|.. |     .  . |  | |   |   ..   .|||...| ||. || .   .....|  |   ...   |..|||||. | |.| 
aekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.....  |.| .|| ..||... . ||. . ..| ..   . .  ...
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_PTPN12_pd Subfamily PTPN12 3-146 8.8e-20 65.7 In-house 125-270 (290) alignment 
Range on Protein: 3-146
Range on HMM: 125-270/290.0
CYQYWRES--DTISFGEYFVKCLLSKDCN-GYIERKLHIRSDkndSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSR
| .|| |.  ... |||. |..   | .. ... | |... .   . |  | ||. |.||  || . . ..|..|..| ..|.     |.|||||  | |
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

SGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMM
 |. ... .. |. ||| .   .|||..  ..|. .. .| |    ... 
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-139 2.2e-19 64.6 In-house 115-254 (274) alignment 
Range on Protein: 3-139
Range on HMM: 115-254/274.0
CYQYWRESDTI----SFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSswdVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDT
| .|. ..  .     .|.  .|    ...|.|  ||| ... ..  |   |. .  |.||   . ....|.|.....| . ...     .|||||||  
CavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
. | |.. ..|||. | ..|.||||....  .|  . | | | 
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-150 1.3e-18 61.9 In-house 106-261 (270) alignment 
Range on Protein: 3-150
Range on HMM: 106-261/270.0
CYQYWRES--DT--ISFGEYFVKCLLSKDCNGYIERKLHIRsdkNDSSSWDVVQFQVTNWPTDGVIREPR------TVLQVIDDV-IHRQQKIGGGPVVV
| .|| ..  ..  ...|.  |  | ..  .||| ..|...   .....  .| |. ..|| .|| ||.        .|... .|  .....  ..|..|
CerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
|||. | |.|.   . ||..  . .. ||| .. . .|. ..  | . . .. .   ..
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPN9_pd Subfamily PTPN9 3-131 2.4e-18 61.2 In-house 127-268 (297) alignment 
Range on Protein: 3-131
Range on HMM: 127-268/297.0
CYQYWR--ESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ------------KIGGGP
| |||   | ....||.. |. .  .  . | .|.|.|.  |..  |  |. ||.. ||  || ..  ..|.|.. | ..|             .. | |
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRS
.|||||  . |.| .... |.|.. . .|.|||... | .|  
ivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq
0051429 (Phosphotyrosine protein) phosphatases II 3-148 2.9e-18 62.0 In-house 63-220 (272) alignment 
Range on Protein: 3-148
Range on HMM: 63-220/272.0
CYQYWR------------ESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPrtVLQVIDDVIHrqqkigGGPVV
|..||             .  ||..| ..|..|  . .. || |.| ..   . . .  | ... |.||..|| .|.  .|.... . .      ||||.
cdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvl

VHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQVTKSVRRSKPGAVTTLVCIKIMMMM
||||  ..|.|... . . |..  .| .||        .... . .|.  |||| |   ..  .. 
vHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
subfamily_PTPN13_pd Subfamily PTPN13 3-138 4.2e-16 54.0 In-house 119-254 (273) alignment 
Range on Protein: 3-138
Range on HMM: 119-254/273.0
CYQYWRESD--TISFGE-YFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSR
| .|| ||   ..   . . |. |  .. .|.  |.|... |.. . | .|.... ..||  || ...  .||..  | . |.    ||.|||||  . |
chrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
||.. .. ..|.  . .  .|| .. ...|. . | | |
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_PTPN1_pd Subfamily PTPN1 3-150 7.9e-15 49.3 In-house 113-268 (290) alignment 
Range on Protein: 3-150
Range on HMM: 113-268/290.0
CYQYWRES---DTISFG--EYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDT
|.||| .    ... .   .. || .  .. . |. |.|..  ...   . ....|  | ||  || . | . |. . .| .    .   ||.|.|||  
caqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
. ||| .| |   | . ....    ||. .|   .|. . | . |   ..   . ..
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3-151 1.8e-14 48.1 In-house 136-279 (290) alignment 
Range on Protein: 3-151
Range on HMM: 136-279/290.0
CYQYWR--ESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRS
| ||.   | ....|||. | | ...| .  | .|.    ||..  .  .  ...  ||   |     ..|...  .  |.     ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrt

GVYCSVSIALeQCKAEG-VVDVFQVTKSVRRSKPGAVTtlVCIKIMMMMMIM
| . .. ..| |.  .|  .|. .. ...|.|. ..|   | |. .... |.
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvq..vdiqylalveil
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-138 2.2e-14 48.2 In-house 94-226 (239) alignment 
Range on Protein: 3-138
Range on HMM: 94-226/239.0
CYQYWRESdTISFGEYFVKCLLSKDCNGYIERKLhIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| .| |  . .  |    ..    || | . . |.  ..    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
chqywpds.tskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.  .   | |.| .  ||.|.  |..|  .|  | |
flvidamlrqakkqktvdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-139 2.2e-14 48.2 In-house 93-226 (239) alignment 
Range on Protein: 3-139
Range on HMM: 93-226/239.0
CYQYWRESdTISFGEYFVKCLLSKDCNGYIERKLhIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| .| |  . .  |    ..    || | . . |.  ..    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
chqywpds.tskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
.  .   | |.| .  ||.|.  |..|  .|  | | 
flvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_PTPN14_pd Subfamily PTPN14 3-153 5.9e-13 43.5 In-house 135-296 (300) alignment 
Range on Protein: 3-153
Range on HMM: 135-296/300.0
CYQYWRES----DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDV---IH-RQQKI----GGGPVV
...|. ..    .|. ||.. |   .|.| . .| ..|...     .   .|. .| |.|| .|| ..... |. ...|    .  ....       ||.
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMI
||||. | |.||   . . ..  . . ..|. .| . .|. .   | ||   | .  ..| ..
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPRN_pd Subfamily PTPRN 3-147 7.6e-13 42.8 In-house 142-286 (297) alignment 
Range on Protein: 3-147
Range on HMM: 142-286/297.0
CYQYWRESDTISFGEYFVKcLLSK--DCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRS
|..|| .  .  .. | |. |.|.   |. |. | ....  .. | .  | ||    ||  ||  .....|.    |  .  .    |.|||||| . |.
ckrywpdeGsevyhiyevh.lvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrt

GVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
|||. . . |..  |    .|.    . .|  .|| | |   ......
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-153 1.5e-12 42.2 In-house 113-259 (290) alignment 
Range on Protein: 3-153
Range on HMM: 113-259/290.0
CYQYWRESD--TISFGEYFVKCLLSKDCNGYIERKLHIRSDknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRS
| .| .||    . |.   |||      .. ..|.| .. |  |   . |   .. .| .  | ....|.|..|. |  ..      ||.||| | .|||
CakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd..deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrs

GVYCSVSIALEQCK-AEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMI
 .  .. ..       .| | . .| |..|. .  |.|.      ..  .....
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-149 3.1e-12 40.9 In-house 122-273 (287) alignment 
Range on Protein: 3-149
Range on HMM: 122-273/287.0
CYQYWRESD-TISFGEYFVKCLlSKDC--NGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSD
||.|| | .  .  | | |  | ..|     |  | | .  | .   .  | |... .|| ...        | ||.| . .  ...  . ||.|||.. 
cykywPerevPmrvGGysvvll.dydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

TVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
 . |||.. .. . ... .  | ||| .|   .|  . . | . | .....  .
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
0046846 (Phosphotyrosine protein) phosphatases II 3-141 7.5e-11 37.6 In-house 65-161 (176) alignment 
Range on Protein: 3-141
Range on HMM: 65-161/176.0
CYQYWRESDTISFgeyfvkcllskdcngyierklhirsdkndssswdvvQFQVTNWPTDGVIREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGV
|..|| |  . ..                                    |.....||  ||    . .|.... .  ....  ||||.||||  ..|.|.
cpnywpeleklgi....................................qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgt

YCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLVC
..        .. |  ..|... . ||. .| |||.|   
lvaay....llelekglsveealalvreqRplgavqtpeQ
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4-154 4.6e-16 53.3 In-house 129-279 (439) alignment 
Range on Protein: 4-154
Range on HMM: 129-279/439.0
YQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDS-SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||  .. . .|.  |..    .   |. | ...  ... .     |.||. . ||   |  .   ||. .  .   ..|   ||||||||  | |.| 
ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLvCIKIMMMMMIMMIV
  .. ||||| |.|  ||.  . | .|. .   | .| |  ...   ..  .
iialdialeqlklenkvdikgivkvlrkqrkqmvqal.cqyvfiynavledi
0051082 (Phosphotyrosine protein) phosphatases II 5-141 1.7e-11 39.4 In-house 51-141 (151) alignment 
Range on Protein: 5-141
Range on HMM: 51-141/151.0
QYWRESDtisfgeyfvkcllskdcngyierklhirsdkndsssWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYC
.|..| .                                     .|.......||. |.   . .||.... ...     ..|||.||||  ..|.|. .
eylpelg....................................ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlv

SVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLVC
 . . |..      |..... . .|.. ||.|..   
alylmllg......vsleealeeyrlkrpgvvqpnqq
0049260 (Phosphotyrosine protein) phosphatases II 7-139 8.4e-11 37.3 In-house 55-136 (152) alignment 
Range on Protein: 7-139
Range on HMM: 55-136/152.0
WresdtisfgeyfvkcllskdcngyierklhirsdkndssswdvvQFQVTNWPTDGVIREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSV
.                                            |.. ..|| .||   .  .|.... . .. ..  ||||.||||  |.|.|...  
i............................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaa

SIALeqckaeGVVDVFQVTKSVRRSKPGAVTTL
 . |        |..... . ||. .||||.. 
ylml......lgvsleeavalvrekRpgavpnp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 20-139 1.8e-12 41.8 In-house 130-245 (267) alignment 
Range on Protein: 20-139
Range on HMM: 130-245/267.0
VKCLLSKDCNGYIERKLHIRSdKNDsSSWDVVQFQVTNWPTDGVirePRTVLQVIDD-VIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV
|.  | |. | |    | ..  ||. |. .|. .   .|  .      .  |. .   . . | . |. |.||.||| | ||| .  .   ||. | |||
vehslekeendyqiitlelkf.kne.sahnvtlyyykkwnintn...nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegv

VDVFQVTKSVRRSKPGAVTTL
.|.|.  . .|  ..| | |.
sdifdflrkirsqriglvdtk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 31-145 4e-06 20.8 In-house 164-273 (301) alignment 
Range on Protein: 31-145
Range on HMM: 164-273/301.0
YIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRR
 ..|.|...   .. ..  |. .| ..|.  || .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .| 
iskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlre

SKPGAVTTLVCIKIM
 .  .| |   .  |
hrwngvqtnsqlywm
0044763 (Phosphotyrosine protein) phosphatases II 37-145 8.1e-09 30.9 In-house 75-163 (178) alignment 
Range on Protein: 37-145
Range on HMM: 75-163/178.0
HirsdkndssswdvvqFQVTNWPTDGVIREP-RTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRSKPgA
.               .|. ..|...    . .  .. . . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .
g...............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i

VTTLVCIKIM
|..   .. .
vpnpgqlrqL
0048076 (Phosphotyrosine protein) phosphatases II 38-143 1.2e-11 40.0 In-house 36-133 (145) alignment 
Range on Protein: 38-143
Range on HMM: 36-133/145.0
IRSDKNDSSsWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKSVRRSKPGAVT
. |.... .   ..|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  ||||.
ltselelle.rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavp

TLVCIK
.   ..
npgqlr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 40-140 6.9e-13 42.7 In-house 125-223 (392) alignment 
Range on Protein: 40-140
Range on HMM: 125-223/392.0
SDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
 || |.    | ||..|.|| ..| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | 
gdkgdd.artvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

V
 
e
0048179 (Phosphotyrosine protein) phosphatases II 40-140 4.8e-11 38.1 In-house 48-132 (144) alignment 
Range on Protein: 40-140
Range on HMM: 48-132/144.0
SdkndssswdVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKSVRRSKPGAVTTL
          ..|.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... . ||.  ||||.. 
e.........giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

V
 
g
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 44-166 7.4e-11 36.0 In-house 184-299 (302) alignment 
Range on Protein: 44-166
Range on HMM: 184-299/302.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVciK
.     |  .. . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| .    .
kkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq..q

IMMMMMIMMIVLFRINTVQYMKS
.. .....   |    .| |..|
liylllcvtkglmekagvlylrs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 44-121 5.6e-07 23.2 In-house 214-291 (349) alignment 
Range on Protein: 44-121
Range on HMM: 214-291/349.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIALEqckaegvvdV
 .. . ..|.|| ||.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.         .
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls.........i
subfamily_ptpA1_pd Subfamily ptpA1 44-111 2.3e-06 21.6 In-house 182-254 (418) alignment 
Range on Protein: 44-111
Range on HMM: 182-254/418.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
.  . |. |.|   ||   .    . . |..  .  ||..|        |..||||  | |.| .|.  | ..
egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 46-139 2.5e-14 47.4 In-house 87-424 (440) alignment 
Range on Protein: 46-139
Range on HMM: 87-424/440.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVV-------------------------------------------------------
 |  . |..   ||  || .    ||..|.|| . |.| | ||..                                                       
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

----------------------------------------------------------------------------------------------------
                                                                                                    
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsv

-----------------------------------------------------------------------------------------VHCSDTVSRSG
                                                                                         |||   .  ||
tfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesg

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|.|.|   ||| . .| .||||  . .| |.|  | ||
vfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 46-140 1.5e-07 25.7 In-house 93-191 (199) alignment 
Range on Protein: 46-140
Range on HMM: 93-191/199.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLV
|. .. ..| | |           |  |.   .| .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...| 
streishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 46-138 1.5e-07 25.7 In-house 174-262 (307) alignment 
Range on Protein: 46-138
Range on HMM: 174-262/307.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTT
 |  . ..| .|||  || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |
ksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 46-140 1.5e-07 25.8 In-house 92-190 (198) alignment 
Range on Protein: 46-140
Range on HMM: 92-190/198.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLV
|. .. ..| | |           |  |.   .| .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...| 
streishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 47-179 2.3e-08 28.1 In-house 214-343 (350) alignment 
Range on Protein: 47-179
Range on HMM: 214-343/350.0
SWDVVQFQVTNWPTDGVIREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKaegvvDVFQVTKSVRRSKPGAVt
 . | |.|| ||.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.. .     .. ..||  |...  |  
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfe.....ilenltkesrkldvaak.

tlvcIKIMMMMMIMMIVLFRINTVQYMksDTYVYNNNCIVFY
    .. .. ...  .   ||. || .  | ...  ... ||
....trDlisiivnelrkqrismvqnl..dqfifiYeallfy
0043147 (Phosphotyrosine protein) phosphatases II 48-139 1.5e-12 43.1 In-house 63-147 (172) alignment 
Range on Protein: 48-139
Range on HMM: 63-147/172.0
WDVVQFQVTNWPTDGVIrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSVRRSKPGAVTTL
  ..|.. ..||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . ||. .||||.. 
rlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnp
0049772 (Phosphotyrosine protein) phosphatases II 48-139 9.4e-08 27.6 In-house 178-266 (314) alignment 
Range on Protein: 48-139
Range on HMM: 178-266/314.0
WDVVQFQVTNWPTdGVIREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTL
  ....  ...|  |    .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|
rlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieql
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 49-157 6.7e-07 23.6 In-house 172-274 (288) alignment 
Range on Protein: 49-157
Range on HMM: 172-274/288.0
DVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIkIMMMM
 | .  . .|. |||  .  . |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .. | ..  |..|     . .  
ivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqy.lyvhr

MIMMIVLFR
...  .|..
cvleelllk
PTPc_DSPc_SM00012 50-148 1.1e-20 69.1 In-house 2-102 (105) alignment 
Range on Protein: 50-148
Range on HMM: 2-102/105.0
VVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
| ....|.||  || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|.    ....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

M
.
a
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 53-151 3.1e-07 24.3 In-house 195-288 (310) alignment 
Range on Protein: 53-151
Range on HMM: 195-288/310.0
FQVTNWPTDGVIREP-RTVLQVIddviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIM
 .  |||  ||  |   || | .      |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . | .   |. ...|.
ikwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_CG42327_pd Subfamily CG42327 86-139 1e-07 25.9 In-house 247-301 (319) alignment 
Range on Protein: 86-139
Range on HMM: 247-301/319.0
GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTL
 ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 90-136 4.8e-06 20.9 In-house 2-48 (69) alignment 
Range on Protein: 90-136
Range on HMM: 2-48/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAV
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv
fn3 Fibronectin type III domain 396-468 1.4e-14 47.2 Pfam-A 2-78 (85) alignment 
Range on Protein: 396-468
Range on HMM: 2-78/85.0
APSSLTVVNKTATTITVSWTTLD--SSDADGYVVNVTDSDTVQ---TVQVEGNSInTVTLNGLRGGTTYSITVRAYKE
||. |.| . |.|..|.||.  .  ... .|| | . .... .   ...|....  .|||.||. ||.|...|.|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavng