Gene PTPRD-71 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP130_AA protein Get Run
AqueP130_AA_89-306 phosphatase_domain Get Run
AqueP130_AA_1251-1519 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 77-159 4.9e-10 33.9 In-house 8-90 (306) alignment
Range on Protein: 77-159
Range on HMM: 8-90/306.0
TLPVSMEELGNHVATCHSNGFEEQYKSLYTGE---DKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpNLDMCQREYINANYVH
..   ..|| ..  . . .||||....| . |     | . |   .||  ||.|||  .|..|..|    . .. . .||||||..
eieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyik

subfamily_PTPRB_pd Subfamily PTPRB 78-159 1.8e-09 32.1 In-house 5-88 (293) alignment
Range on Protein: 78-159
Range on HMM: 5-88/293.0
LPVSMEELGNHVATCHS---NGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVH
 |...|.. .||.. ..    .| |.|..|   |.|.....  .. |.| ||..||  || .|. | .    |  . .||||||..
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyip

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 79-159 2.6e-14 48.1 In-house 3-83 (305) alignment
Range on Protein: 79-159
Range on HMM: 3-83/305.0
PVSMEELGNHV---ATCHSNGFEEQYKSLYTGeDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
......| ...    . ...|.|.||||||.  ..|. .| .| ||| ||.|.||..||.|| | ....||  ...||||.||.
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvd

subfamily_PTPRD_pd Subfamily PTPRD 79-159 4.4e-12 40.4 In-house 4-85 (564) alignment
Range on Protein: 79-159
Range on HMM: 4-85/564.0
PVSMEELGNHVATCHSN---GFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVH
|....|| .|||  ..|    |||.||.. .|.  ...    . ||| ||..||. || .|. | . ..    . .||||....
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfid

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 79-159 4.8e-09 30.7 In-house 4-85 (319) alignment
Range on Protein: 79-159
Range on HMM: 4-85/319.0
PVSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVH
.. ..|| ... . .|.|   .|...| | ...... .    |.||  ||..||  ||  |..| . ..  . . .||||... 
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfid

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 80-158 3.3e-07 24.7 In-house 2-82 (318) alignment
Range on Protein: 80-158
Range on HMM: 2-82/318.0
VSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSI-GYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYV
.|.|.| .||.  ...|   ..|.|. |   |... |.   .. ||| ||. ||. ||. |. | .    .  . .||||||.
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyi

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 81-159 4.4e-15 50.3 In-house 3-85 (290) alignment
Range on Protein: 81-159
Range on HMM: 3-85/290.0
SMEELGNHVATCHS---NGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVH
 ....|..||. |.   .||..|.|.| .|| ...  .| ...||  |||.|| |||||||||   ..   |. ||||| |..
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik

subfamily_PTPRG_pd Subfamily PTPRG 81-159 8.1e-11 35.8 In-house 2-85 (563) alignment
Range on Protein: 81-159
Range on HMM: 2-85/563.0
SMEELGNHVATCHSNG---FEEQYKSLY---TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQrEYINANYVH
 ..|. .||| .|..|   |.|....|    . .|  ..    ..||  ||  ||. ||  |..|   |. .    .||||||..
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyid

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 81-160 3.1e-07 24.9 In-house 13-94 (298) alignment
Range on Protein: 81-160
Range on HMM: 13-94/298.0
SMEELGNHVATCHSNGFEEQYKSLYTGED----KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHE
 ...| .   . .  |...... | ....    .. ... ...||  ||. .|  .|  |. | ..   .  . .|||| ..| 
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflha

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 81-161 1.8e-06 22.1 In-house 7-88 (315) alignment
Range on Protein: 81-161
Range on HMM: 7-88/315.0
SMEELGNHVAT---CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITL-ITNPNldmCQREYINANYVHEC
 ...|  .||       |||...|.|.  |. .   .     ||  ||. ||  ||  |. | ... .    . .|.|||..   
pldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllend...phsdyvnanfidGy

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 82-160 5.3e-29 95.9 In-house 2-80 (301) alignment
Range on Protein: 82-160
Range on HMM: 2-80/301.0
MEELGNHVATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVHE
.|.||.|||..|||.||||||.|..||||||..|.||.|||.||||||||||||||.| ..||||.||||||||.|...
ledlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 82-159 4.4e-10 34.0 In-house 4-80 (287) alignment
Range on Protein: 82-159
Range on HMM: 4-80/287.0
MEELGNHVATCHS---NGFEEQYKSLYT--GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpnldMCQREYINANYVH
.|..|. ||. |    .||..|.. |     ....  .. ...||  ||...| |.|..|. |        .. .|||| .. 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfid

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 82-162 9.3e-08 26.2 In-house 7-89 (95) alignment
Range on Protein: 82-162
Range on HMM: 7-89/95.0
MEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINaNYVHECC
.  .  ||   |||    |....||.      . ..| || |   ||| ||  ||  |..| |. . |  .  ...  |    |
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvd.gyarknc

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 87-159 5.5e-09 30.5 In-house 13-84 (288) alignment
Range on Protein: 87-159
Range on HMM: 13-84/288.0
NHVATCHSNGFEEQYKSL-YTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
..      .||.|.|.||   ...|| ..|    |.  ||..||  || .|. |   .. .  . .||||.|..
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyid

subfamily_PTPRK_pd Subfamily PTPRK 89-158 4.6e-07 24.0 In-house 16-79 (314) alignment
Range on Protein: 89-158
Range on HMM: 16-79/314.0
VATCHSNGFEEQYKSLYTGedksCSIGYSEDNKAFNRFKNITVYDDNRITLITNpnLDMCQREYINANYV
. .... || |.|.||. |          ..|.. ||...|  ||  |..|||    .  . .||||...
lkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaali

0040438 (Phosphotyrosine protein) phosphatases II 90-300 1.4e-45 151.4 In-house 13-265 (317) alignment
Range on Protein: 90-300
Range on HMM: 13-265/317.0
ATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHEC----------------------------
     ....|... |..    ..|... ..|| .||...|  ||..|. |   ..       ||||.||.                              
lksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

-----------------CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkiG-
                 |.||| . . ..|....|..|| . ..|.. |.. |.  ..| |  | .|. |.|| .||   |...|. ...| . ..  . 
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dp

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
||||.||||. |.|.|... . ..|||.. || |||... | .|. .||||.|.|  
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqy

0043336 (Phosphotyrosine protein) phosphatases II 91-300 4.3e-43 143.2 In-house 16-266 (278) alignment
Range on Protein: 91-300
Range on HMM: 16-266/278.0
TCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHEC-----------------------------
     ........|..    ..||.....|| .||.|.|  || .|. |   ..       ||||.||                                
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

----------------CYQYWReSDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkIGGG
                |.|||  .. ..|....|..|. . ...|. |.. |   ... |  |.... ..|| .||   . ..|. . .|.....   .|
ttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
||.||||. |.|.|... . ..||| . || ||.... | .|. .||||.|..  
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 92-300 2.7e-21 70.4 In-house 17-225 (392) alignment
Range on Protein: 92-300
Range on HMM: 17-225/392.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLIT-NpnlDMCQREYINANYVH----ECCYQYWRESDIIQYEEYFVKCLSSKD
 ||  | |... |   .    ...  |.|.  ||.|||  || .|. |   .   |. ...|.|| |..    | .|   .   .   ....   .  . 
rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid...dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

CNGYIERKFaVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSV
.   .  |.  . .|  .   | ||..|.|| ..| .   ..|..| ||     .    |...|||  | |.||  |.   . ..|   .||||..   .
ttiamvtkl.kegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtni

RRSKPGAVTTLEIH
|| .|  | | | .
rrkrpymvqtkeqy

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 92-159 9.7e-07 23.2 In-house 20-85 (325) alignment
Range on Protein: 92-159
Range on HMM: 20-85/325.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVH
   .||  ... | . . ..  .    .||| |||||.  .| .|. | |    |  . .||||.|..
qdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylr

0039614 (Phosphotyrosine protein) phosphatases II 93-300 2.4e-42 140.8 In-house 30-278 (297) alignment
Range on Protein: 93-300
Range on HMM: 30-278/297.0
HSNGFEEQYKSLYTGEDKsCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMcQREYINANYVHEC-------------------------------
 ..........|.   .  .||.... || .||.|.|  ||..|. | .... |.    ||||.||                                  
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

--------------CYQYWRESDIiQYEEYFVKCLSSKDCNGYIERKFAVQLekSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGP
              |.||| |.   .|....|..|. . ..||. |.. |.   .. |  | .||.|.|| .||   ....|.....| .....  .|||
vivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
|.||||. |.|.|...   ..|||.. || |||... | .|. .||||.|..  
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 93-159 4.9e-10 34.0 In-house 13-78 (281) alignment
Range on Protein: 93-159
Range on HMM: 13-78/281.0
HSNGFEEQYKSLYT-GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
...|| |.|..|.  | |.. .  ....|.  ||..||. ||  |...  | .    . .|||||.| 
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvp

0051299 (Phosphotyrosine protein) phosphatases II 94-299 3.9e-46 153.2 In-house 22-274 (288) alignment
Range on Protein: 94-299
Range on HMM: 22-274/288.0
SNGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVH---------------------------------
 .|..|... |.    | ..|... . |.  ||...|  ||..|. | . ..  .    ||||.|..                                 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

------------ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLE----KSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkIG
            | |.||| ... ..|....|..|| . ...|. |.. |.      ... | .| .|..|||| .||   |. .|. . .|.. ..  |
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sg

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
|||||||||. |.|.|... . ..||| ..||.|||... | .|. .||.|.|.| 
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq

0045450 (Phosphotyrosine protein) phosphatases II 94-299 1.2e-42 142.1 In-house 26-292 (307) alignment
Range on Protein: 94-299
Range on HMM: 26-292/307.0
SNGFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdMCQREYINANYV--------------------------------
 .|.......|.  ...   ..||.... || .||.|.|  ||..|. | . ..  .    ||||.||                                
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

---------------------HECCYQYWRESD-IIQYEEYFVKCLSSKDCNGYIERKFAVQLE-KSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEV
                     .| |.||| ...  ..|....|..|| . ..||. |.. |.   ... |  | .|. |.|| .||   . ..|. |.||
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

IHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLEI
 . ...  .||||.||||. |.|.|...   ..|.| ..||.   ||.... | .|. .||||...| 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeq

subfamily_Ptp69D_pd Subfamily Ptp69D 94-159 1.3e-08 29.3 In-house 21-85 (307) alignment
Range on Protein: 94-159
Range on HMM: 21-85/307.0
SNGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
  |... |..|  .  |||....  ..|.  ||...|. .|..|. | . .  .  . .||||....
dfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfik

0050432 (Phosphotyrosine protein) phosphatases II 95-302 8e-49 162.0 In-house 42-290 (308) alignment
Range on Protein: 95-302
Range on HMM: 42-290/308.0
NGFEEQYKSLYTGED-KSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDmCQREYINANYVHEC--------------------------------
 ..||... |.   .  ..|... ..|| .||.|.|  || .|. |      |     ||||.||. .                                
glleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

---------------CYQYWRES---DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqkiG
               |.||| ..   ....|. ..|..|| . ...|. |.. ..  ... |  | .|. |||| .||  .|. .|. ...| ...   .
vIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...p

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
|||.|||||. |.|.|... . ..||| ..|| ||||.. | .|. .||.|.|.| ...
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf

0046845 (Phosphotyrosine protein) phosphatases II 96-301 1.1e-45 151.6 In-house 1-264 (284) alignment
Range on Protein: 96-301
Range on HMM: 1-264/284.0
GFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNlDMCQREYINANYVHEC-------------------------------
|.||... |.    |   |.|... . |.  ||.|.| .||..|. | . .. |.   .||||.||. .                               
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

-------------------CYQYWRESD-IIQYEEYFVKCLSSKDCNGYIERKFAVQLEK-SSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ
                   |.||| ...  ..|....|..|| . ...|. |.. .. .. .. |  | .|..|.|| .||  .|. .|. ...| . ..
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

K-IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLEIHY
.  ||||.|||||. |.|.|... . ..||| ..||   .|||... | .|. .||.|.|||  .
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr

DSPc_SM00195 97-159 3.5e-07 25.2 In-house 2-63 (263) alignment
Range on Protein: 97-159
Range on HMM: 2-63/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVH
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik

PTPc_SM00194 97-159 3.5e-07 25.2 In-house 2-63 (263) alignment
Range on Protein: 97-159
Range on HMM: 2-63/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVH
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik

0047943 (Phosphotyrosine protein) phosphatases II 99-302 5e-44 146.2 In-house 16-263 (273) alignment
Range on Protein: 99-302
Range on HMM: 16-263/273.0
EQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHE-------------------------------------
|... |.    . ..|... ..|| .||.|.|  ||..|. |      ..    ||||.||                                       
eefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

--------CCYQYWRESD---IIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVV
         |.||| ..     ..|....|..|| . ...|. |.. ..  ... |  | .|..|.|| .||   .  .|. |..| . .... ..||||
elvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvv

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
||||. |.|.|... . ..|.| ..|| |||... | .|. .||.|.|.|  ..
VHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf

0045098 (Phosphotyrosine protein) phosphatases II 101-300 2.2e-37 124.4 In-house 14-261 (278) alignment
Range on Protein: 101-300
Range on HMM: 14-261/278.0
YKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITlitnpnldmcqrEYINANYV------------------------------------------
.  | .|   ... .  ..|...||.|.|  || .|.             .||||.|.                                          
efllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-HECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLE----KSSSSWNVLQFQVTNWPTDGVIREP--RTVLQVIDEVIHRQQK----------
 .| |.||| |.. ..|....|..|| . .. |. |.. |.      ..  |..| ... ..||  ||  .|  . .|...... .....          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

--IGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLEIH
   .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||  
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqy

0049772 (Phosphotyrosine protein) phosphatases II 104-302 4e-14 48.5 In-house 30-270 (314) alignment
Range on Protein: 104-302
Range on HMM: 30-270/314.0
LYTGEDKSCSIGYSEDNKAFNRFKNITVYDdNRITLitnPNLDMCQREYINANYVHECcYQY------------------------WRESD---------
| .  .... ... . |.  ||...|  .| ||  |   |.|..    ||||.||. .  ..                        || .          
lsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

-----------------------IIQY---------------EeyfvkclsskdcngyierkfAVQLEKSSSSWNVLQFQVTNWPTdGVIREPRTVLQVI
                       ...                .                     .. ...  . .....  ...|  |    .. .....
vmsrdevladelsrLdaAlgKtpllildgngneptaadlellk....................eelydpelferlgikylripvpD.gsaplledfdefl

DEVIHRqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTLEIhYY
. .        ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .||  |.
efieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleq.ye

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 108-164 9.6e-06 19.8 In-house 21-69 (267) alignment
Range on Protein: 108-164
Range on HMM: 21-69/267.0
EDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmcqreYINANYVHecCYQ
.   .|  ..|.|...||. .   |||.|. | |. .       |||| ||.  .|.
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyve..gyk

0036941 (Phosphotyrosine protein) phosphatases II 109-300 3.7e-44 146.6 In-house 28-266 (297) alignment
Range on Protein: 109-300
Range on HMM: 28-266/297.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHE---------------------------------------------CCY
. |.|.. ...|.  ||.|.|  ||..|. |      |     ||||.||                                                |.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWRES--DIIQYEEYFVKCLSSKD--CNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRS
||| .   . ..|....|..|| .   ...|. |.. |.  ... |  | .|..|.|| .||   |...|. |..| ...... .||||.||||. |.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLEIH
|... . ..|.| .    || ||.... |..|. .||||.|||  
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqy

subfamily_PTPN12_pd Subfamily PTPN12 110-159 6.7e-06 20.2 In-house 30-77 (290) alignment
Range on Protein: 110-159
Range on HMM: 30-77/290.0
KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
 | . | .| |.. ||.|.|  || .|..| .. . .  . .|||||...
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfik

0040439 (Phosphotyrosine protein) phosphatases II 111-299 5.6e-40 132.9 In-house 2-234 (249) alignment
Range on Protein: 111-299
Range on HMM: 2-234/249.0
SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVH---------------------------------------------ECCYQY
..|... . ||  ||...|  || .|. |   |.|  .   ||||.|..                                             | |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
| ... ..|....|..|| . ...|. |.. ..  . ..|  ||..|.|.|| .||   . ..|. |..| . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
 ..||| . |. ||.... | .|. .||||...| 
ylmleqlekelgvdleeavkllrsqRpgavqnpeq

0042113 (Phosphotyrosine protein) phosphatases II 112-301 4.7e-38 126.4 In-house 1-233 (245) alignment
Range on Protein: 112-301
Range on HMM: 1-233/245.0
CSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYV---------------------------------------------HECCYQYW
.|... . || .||...|  ||..|. |   ..   .   ||||.||                                             .. |.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

RESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
 ......|....|..|| . ...|. |.. |. .... | .|.... ..|| .||   ....|.....| . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHY
.||| ..|. |..... | .|. .||||.|..  .
mleqlekelgvsleeavkelrsqRpgavqtpsqyr

0037934 (Phosphotyrosine protein) phosphatases II 112-299 3.3e-31 104.1 In-house 2-230 (243) alignment
Range on Protein: 112-299
Range on HMM: 2-230/243.0
CSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMcqREYINANYV----------------------------------------------HECCYQY
.||. .. |.  ||...|  ||..|. |      .     |||||..                                              .| |.||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WReSDIiQYEEYFVKCLSSKDCNGYIERKFAVQLEK-SSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQK-------IGGGPVVVHCSDTVSR
|  ... .|....|..||.. ...|. |.. ..  . .  ...| ... ..||  ||  .|  .|. .|||.  ...        .||||.||||  |.|
wp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLEI
.|...   . |...   | ||.... | .|. .|| ||.|.. 
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq

0041856 (Phosphotyrosine protein) phosphatases II 120-303 6.2e-18 60.5 In-house 1-163 (182) alignment
Range on Protein: 120-303
Range on HMM: 1-163/182.0
NKAFNRFKNITVYDDNRitlitnpnldmcQREYINANYVHEC------------------------------------CYQYWResdiiqyeeyfvkcls
|.  ||...|  || .|               |||||..  .                                    ...||                 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp................

skdcngyierkfavqlekSSSSWNVLQFQVTNWPTDGVIRePRTVLQVIDEVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGvVDVFQVT
                  .    ...|.. ..|| .||   ....|. |.||..      ||||.||||  |.|.|...   . ...    | |..... 
..................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeav

KSVRRSKPGAVTTLEIHYYQ
| ||. .||.|.|.. ... 
klvrsrRpgmvitpnqyffl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 147-297 1.2e-14 49.2 In-house 98-245 (290) alignment
Range on Protein: 147-297
Range on HMM: 98-245/290.0
MCQREYINANYVHECCYQYWRES--DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSsSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqkigg
.|..|  .||  .. | .| .||  ......   ||| |    .. ..|.  |. ..    . |   .. .| .  | ....|.|..|. |  ..     
lcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkvkask.....

GPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKSVRRSKPGAVTTL
 ||.||| | .||| .  .. ..       .| | . .| |..|. .  |.|. 
tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsa

0044763 (Phosphotyrosine protein) phosphatases II 149-298 5e-09 31.5 In-house 17-158 (178) alignment
Range on Protein: 149-298
Range on HMM: 17-158/178.0
QREYINANYVHECC------------------------------------YQYWRESDIiqyeeyfvkclsskdcngyierkfavqleksssswnvlqFQ
  .||||... .                                      ..|| |.                                         .|
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeag.......................................iq

VTNWPTDGVIREP-RTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRSKPgAVTTLE
. ..|...    . .  .. . | |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .
ylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpg

0051429 (Phosphotyrosine protein) phosphatases II 152-298 4.3e-19 64.7 In-house 6-212 (272) alignment
Range on Protein: 152-298
Range on HMM: 6-212/272.0
YINANYVH-----------------------------------------------ECCYQYWR------------ESDIIQYEEYFVKCLSSKDCNGYIE
||||..|                                                . |..||             .   | |  ..|..|| . .. || 
yiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

RKFAVQLE-KSSSSWNVLQFQVTNWPTDGVIREPrtVLQVIDEVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQVT
|.. . |. . . .  |.... |.||..|| .|.  .|...... .      ||||.||||  ..|.|... . . |..  .| .||        .... 
rellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

KSVRRSKPGAVTTLE
. .|.  |||| | |
eelraqrpgavqtee

0046846 (Phosphotyrosine protein) phosphatases II 152-298 3.9e-11 38.5 In-house 14-160 (176) alignment
Range on Protein: 152-298
Range on HMM: 14-160/176.0
YINANYVHECCY-----------------------------------------QYWREsdiiqYE---Eyfvkclsskdcngyierkfavqleksssswn
|||||..  ...                                         .|| |     .|                                   
yinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.....leklgi...............................

vlQFQVTNWPTDGVIREpRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLE
  |.....||  ||    . .|......  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |
..qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

0051082 (Phosphotyrosine protein) phosphatases II 153-306 1.5e-13 46.1 In-house 6-148 (151) alignment
Range on Protein: 153-306
Range on HMM: 6-148/151.0
INANYVHE----------------------------------CCYQYWRESDiiqyeeyfvkclsskdcngyierkfavqlekssssWNVLQFQVTNWPT
||..|| .                                   |..|..| .                                    .||......||.
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg...................................ievlhipildwpd

DGVIREPRTVLQVIDEVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLEIHYYQAMD
 |.   . .||........     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. . ...| ..
pglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

0036282 (Phosphotyrosine protein) phosphatases II 159-298 3e-16 55.0 In-house 51-157 (174) alignment
Range on Protein: 159-298
Range on HMM: 51-157/174.0
HECCYQYWREsdiiqyeeyfvkclsskdcngyierkfavqlEKSSSSWNVLQFQVTNWPTDGVIREPRtVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
.. |..|| |                                ... . ...|.. ..|| .||   .  .|.....| . ... .||||.||||  |.|.
lykcinywpe...............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRt

GVYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTLE
|. .   . | . . |..||.... ...|. .||.|.| .
Gtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

0049260 (Phosphotyrosine protein) phosphatases II 159-302 1.6e-11 39.6 In-house 48-141 (152) alignment
Range on Protein: 159-302
Range on HMM: 48-141/152.0
HECCYQYWresdiiqyeeyfvkclsskdcngyierkfavqleksssswnvlQFQVTNWPTDGVIREPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRS
...|.||.                                           |.. ..|| .||   .  .|.... . .. ..  ||||.||||  |.|.
klkceqyi...........................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRt

GVYCSVSIALeqckaeGVVDVFQVTKSVRRSKPGAVTTLEIHYY
|...   . |        |..... . ||. .||||.. .  ..
gtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 160-310 1.2e-75 249.0 In-house 125-294 (301) alignment
Range on Protein: 160-310
Range on HMM: 125-294/301.0
ECCYQYWRESDIIQYEEYFVKCLSSKDC-------------------NGYIERKFAVQLEKssSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ
..|.|||..|.  ..|....... ....                   ||||||||.|. .|  |||.|||.|||.||.|||.|||||||||||.||||||
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE--IHYYQAMDRLLV
||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||||  .. |...|. | 
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 160-301 2.3e-50 166.5 In-house 129-272 (305) alignment
Range on Protein: 160-301
Range on HMM: 129-272/305.0
ECCYQYWRESDII--QYEEYFVKCLSSKDCNGYIERKFAVQL-EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVS
..|.||| ||     ...|. |.  |.|  ..|||||. .   .... | .|||.|.|.|| .|| ... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEiHY
|.||...|.||||..|.|.|||||.|.| .|......|.||. .|
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtld.qY

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 160-299 1.9e-47 156.6 In-house 131-271 (290) alignment
Range on Protein: 160-299
Range on HMM: 131-271/290.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKS-SSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
. |.||| .||  .|.|. .| |. . .|.|||||. |. ..|  .. .| |.|.|||. .| . .| |.|.|| |... | | | ...||||||||.||
vkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|.|.. .....|| |||.||||| || |  ||| |.| . 
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 160-299 2e-43 143.4 In-house 126-266 (287) alignment
Range on Protein: 160-299
Range on HMM: 126-266/287.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEK-SSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
| ||||| |.. . . || .. |. .  .||||||. |. .. ...  .| |.|.|||.  | . ||.|.| ||.| .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
...|.. .....|| |||.||||| || |  |||.| | | 
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 160-299 7.2e-27 89.3 In-house 131-272 (297) alignment
Range on Protein: 160-299
Range on HMM: 131-272/297.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIR--EPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSR
. | .|| .. . .. .  |. || ....|.|.|.. |. .|. .   | |.| ..||.. | |  . ...|..|.|| .  ..   ||..|||.  | |
kkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
 ||....   . . | |  ||.|.. | .|...|  | | | 
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

subfamily_PTPRA_pd Subfamily PTPRA 160-300 9.2e-27 88.8 In-house 141-284 (330) alignment
Range on Protein: 160-300
Range on HMM: 141-284/330.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQ----LEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGgPVVVHCSDTV
| |.||| .  .. | .  |.   .. .. |  ||| ||      .  .|  | ||  | ||  ||  ||. .|... .| . .|. .| |.|||||  |
ekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
 |.| .. ..  ||. |||..||||.. |..|  .|  | |.| .
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

subfamily_PTPN6_pd Subfamily PTPN6 160-299 7.4e-24 79.3 In-house 138-285 (306) alignment
Range on Protein: 160-299
Range on HMM: 138-285/306.0
ECCYQYWRESDI-IQYEEYFVKCLSSKDCNGYIERKFAVQ-LEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIG---GGPVVVHCSDT
| |..|| ..    .| .. |...|.|. . || |.. |.  .|.... .| |.. ..||  || ..| .||. ...| ..|...     ||.|||||. 
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLEI
. | | .  . | |.. . .|.   .|. .. ||||. . | | | . 
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqq

subfamily_PTPRG_pd Subfamily PTPRG 160-302 7.7e-23 75.5 In-house 131-278 (563) alignment
Range on Protein: 160-302
Range on HMM: 131-278/563.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQL---EKSS---SSWNVLQFQVTNWPTDGVIREPRTVLQVIDEViHRQQKIGGGPVVVHCSD
. | .|| . . ..|..  |.  ...    | .|.. ..    .| .   .  .| |.. |.||  ||   .  ||. .     . .|   ||.||||| 
rkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsa

TVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
 |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |  ..
GvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 160-298 1.1e-22 75.3 In-house 115-253 (283) alignment
Range on Protein: 160-298
Range on HMM: 115-253/283.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSS-SSWNVLQFQVTNWpTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
. | ||| .   ..| |. |        | .| ... .. . |. |.  .  .|| .| ..     .   |  .. ||  |..   ||.||||| .. |.
ikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.|....| .... ..| |||||.| | .|  ...|| ||.
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtld

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 160-298 2.1e-21 71.4 In-house 130-275 (325) alignment
Range on Protein: 160-298
Range on HMM: 130-275/325.0
ECCYQYWRES--DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-----GGGPVVVHCS
. | .|| .   .  ..    ||  . ..   |. |.. |.  |   .  | |||.  |.  || . | |.. ... | . ....     . .|..||||
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | .
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 160-302 3.3e-21 70.9 In-house 138-282 (319) alignment
Range on Protein: 160-302
Range on HMM: 138-282/319.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQL-EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSR
. | |||     |..|.. ||  | .... |. |.. .    |     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
.|||  . . |.. | |  |||... . .|. ..  |  |  ...
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 160-302 4.7e-21 70.5 In-house 102-246 (284) alignment
Range on Protein: 160-302
Range on HMM: 102-246/284.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQL-EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSR
. | |||     |..|.. ||  | .... |. |.. .    |     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
.|||  . . |.. | |  |||... . .|. ..  |  |  ...
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 160-298 1.1e-16 55.8 In-house 85-226 (237) alignment
Range on Protein: 160-298
Range on HMM: 85-226/237.0
ECCYQYWRESDI-IQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWN-VLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVS
. |..|| ..|    |  . |     ..   |  | . .. . .      . |.| | ||  || ..  ..|.   ..|.| ...   || ..|||  | 
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
|.|..  .   | |.| . |||...  .|.   .|  . | .
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

subfamily_PTPN14_pd Subfamily PTPN14 160-297 4.8e-13 43.8 In-house 133-282 (300) alignment
Range on Protein: 160-297
Range on HMM: 133-282/300.0
ECCYQYWRES----DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVI----HRQQKI----GGGPV
| ...|. ..    . ...... |    |.| . .| ... ..   |.   .|. .| |.|| .|| ..... |. ..||     . ....       ||
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
.||||. | |.||   . . ..  . . ..|. .| . .|. .   | ||
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 161-298 2.2e-33 110.7 In-house 130-267 (318) alignment
Range on Protein: 161-298
Range on HMM: 130-267/318.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
 . .|| ... ..|..  |.  ...... |. |.| |. .....| .| |...|.||  ||  .. ..|... .| . ||| | ||.|||||  | | ||
kvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGv

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.. |.| ||. |||..|||||. | .|. ..  | | .
fiavdillerikaealvDvfqtvkqlreqrnlmvqted

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 161-300 2.3e-31 103.9 In-house 92-231 (250) alignment
Range on Protein: 161-300
Range on HMM: 92-231/250.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
 . |||      .| .  |. ||..    |. ||. .  .| ...  | |.. ..||  || .. ..||.....|   ||..| .||.|.||  |.||| 
tyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.. ..  ||. | | |||||.| | .|. .|.||..|| .
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqy

Y_phosphatase Protein-tyrosine phosphatase 161-299 2.1e-30 101.2 Pfam-A 83-225 (235) alignment
Range on Protein: 161-299
Range on HMM: 83-225/235.0
CCYQYWR--ESDIIQYEEYFVKCL-SSK-DCNGYIERKFAVQLEKSSS-SWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTV
 | |||   |..  .|....|..  ..| |...|. ||. .. .|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|.|......|.|||..||. |||.|. |..|...||.|..|| 
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

Y_phosphatase Protein-tyrosine phosphatase 161-299 2.1e-30 101.2 In-house 83-225 (235) alignment
Range on Protein: 161-299
Range on HMM: 83-225/235.0
CCYQYWR--ESDIIQYEEYFVKCL-SSK-DCNGYIERKFAVQLEKSSS-SWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTV
 | |||   |..  .|....|..  ..| |...|. ||. .. .|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|.|......|.|||..||. |||.|. |..|...||.|..|| 
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

DSPc_SM00195 161-300 7.5e-30 99.5 In-house 110-251 (263) alignment
Range on Protein: 161-300
Range on HMM: 110-251/263.0
CCYQYWRES--DIIQYEEYFVKCLSSKDCN-GYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSR
 |..|| |.  .  ..... ||. . . ..  .| |.. .. |. . . .| |.|..|||  ||  ... ||... .| ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.|......|.|.....|  ||.|.. |..| ..||.|.||| .
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY

PTPc_SM00194 161-300 7.5e-30 99.5 In-house 110-251 (263) alignment
Range on Protein: 161-300
Range on HMM: 110-251/263.0
CCYQYWRES--DIIQYEEYFVKCLSSKDCN-GYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSR
 |..|| |.  .  ..... ||. . . ..  .| |.. .. |. . . .| |.|..|||  ||  ... ||... .| ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.|......|.|.....|  ||.|.. |..| ..||.|.||| .
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY

subfamily_Ptp69D_pd Subfamily Ptp69D 161-299 3e-28 93.8 In-house 132-274 (307) alignment
Range on Protein: 161-299
Range on HMM: 132-274/307.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSS-----SSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTV
 | .|| . |..||..  ||. |.. .. ||.|.. |   | .      | .|.|.. |.|.   | . .|..|..|..| . ...   .|.|||||  |
kcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|||.. .... |.|.|||  ||.|...| .|. ..  |. || 
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleq

subfamily_PTPRK_pd Subfamily PTPRK 161-300 4.3e-27 89.7 In-house 127-266 (314) alignment
Range on Protein: 161-300
Range on HMM: 127-266/314.0
CCYQYWRESDIIqYEEYFVKCLSSKDCNGYIERKFAVQL--EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKiGGGPVVVHCSDTVSRS
 |..|| |   . |..  |......  . .. | |.|.    . .    | ||| ..||. .|  . ...|... .| . |.. . |..|||||    |.
kClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
|... ..| |.  . |||||||.. |..| .|.  | | | .
Gtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 161-301 2.5e-22 74.3 In-house 131-269 (288) alignment
Range on Protein: 161-301
Range on HMM: 131-269/288.0
CCYQYWRESDI-IQYEEYFVKCLSSKDCNGYIERKFAVQleKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSG
 | .|| ..|   .| .  |. ..||. . ...||. ..  |. .  .. |.| . || .|| .  . .|.... |   .|.   ||..||||. | |.|
kCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtg

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHY
.. ..  .... ..| ..||. . . .|....  | ||. . 
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYe

subfamily_PTPN3_pd Subfamily PTPN3 161-296 1.3e-21 71.8 In-house 125-260 (280) alignment
Range on Protein: 161-296
Range on HMM: 125-260/280.0
CCYQYWRE-SDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSG
 |.||| | .| ..| |. ||| ...  . |. |.. .. .... . ..||.| ..||  ||  ..  .|.....| .....    |||||||  . |.|
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|.  . .||    |.  | . .. . .|  .   | |
vlilletalalieaaepvypldivrtmrdqramlvqt

subfamily_CG7180_pd Subfamily CG7180 161-299 2.5e-21 70.6 In-house 125-278 (296) alignment
Range on Protein: 161-299
Range on HMM: 125-278/296.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLE----------KSSSSWNVLQFQVTNWPT-DGVIREPRTVLQVIDEVIHRQQKI----GGG
 . .|| .    || | ||. ...|       |.| .. .           .     |..||.| |.  | |     ......  |   ..|.      |
mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
||||..|| .||||||... ..||. . |. ||||.  | .|||.|. | . | 
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenvee

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 161-307 6.1e-21 69.7 In-house 114-262 (274) alignment
Range on Protein: 161-307
Range on HMM: 114-262/274.0
CCYQYWRESDII----QYEEYFVKCLSSKDCNGYIERKFAVQLEKSssSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI--GGGPVVVHCSDT
 | .|. ..  .    .|..  .|  . ...|.|  ||. ..  ..  . .|  .  |.||   . ....|.|....|| . ...     .|||||||  
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEihYYQAMDR
. | |.. ..|||. | ..|.||||....  .|  . | | | |   |. . |
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtse..qyelihr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 161-300 2.3e-20 67.7 In-house 133-268 (315) alignment
Range on Protein: 161-300
Range on HMM: 133-268/315.0
CCYQYWRESDIIqYEEYFVKCLSSKDCNGYIERKFAVQLEksSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGgGPVVVHCSDTVSRSGV
 . .|| . ..| | .. |   | .  . |  | ..|  .  .   .|.|...| ||. || .   .....|  |   ...   |..|||||. | |.| 
kaekywpdkkvi.yGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.....  |.| .|| ..||... . ||. . ..| ..| .
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 161-300 7.3e-19 62.8 In-house 105-253 (270) alignment
Range on Protein: 161-300
Range on HMM: 105-253/270.0
CCYQYWRES--DIIQYEEYFVKCLSSK--DCNGYIERKFAVQleKSSSSWNVLQFQVTNWPTDGVIREPR------TVLQVIDEV-IHRQQKIGGGPVVV
 | .|| ..  . ...|. ..| |...    .||| ..  ..  ..... ... |. ..|| .|| ||.        .|... .|  .....  ..|..|
kCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
|||. | |.|.   . ||..  . .. ||| .. . .|. ..  | . |  
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 161-300 7.6e-16 53.0 In-house 92-229 (239) alignment
Range on Protein: 161-300
Range on HMM: 92-229/239.0
CCYQYWRESDiIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGV
 |.||| .|   .| .  |    ..    || | | .     .    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpdst.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.  .   | |.| .  ||.|.  |..|  .|  | | | .
flvidamlrqakkqktvdifnyvkairedrphmvqtseqy

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 161-300 7.7e-16 53.0 In-house 93-230 (239) alignment
Range on Protein: 161-300
Range on HMM: 93-230/239.0
CCYQYWRESDiIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGV
 |.||| .|   .| .  |    ..    || | | .     .    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpdst.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.  .   | |.| .  ||.|.  |..|  .|  | | | .
flvidamlrqakkqktvdifnyvkairedrphmvqtseqy

subfamily_PTPN1_pd Subfamily PTPN1 161-298 2.4e-15 51.0 In-house 112-258 (290) alignment
Range on Protein: 161-298
Range on HMM: 112-258/290.0
CCYQYWRES---DIIQYE--EYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ-KIGGGPVVVHCSDT
 |.||| .    . ...|  .. || .| .. . |. |.. ..  |.  . ..|.|  | ||  || . | . |. . .| .    .   ||.|.|||  
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLE
. ||| .| |   | . ....    ||. .|   .|. . | . | .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad

subfamily_PTPRN_pd Subfamily PTPRN 161-298 6.4e-14 46.3 In-house 141-279 (297) alignment
Range on Protein: 161-298
Range on HMM: 141-279/297.0
CCYQYWRESDIIQYEEYFVKCLSSK-DCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIhRQQKIGGGPVVVHCSDTVSRSG
 |..|| .     |. | |. .| .  |. |. | | ..  ..| .  | ||    ||  ||  .....|.    |  .  .    |.|||||| . |.|
qckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtG

VYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLE
||. . . |..  |    .|.    . .|  .|| | | .
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd

subfamily_PTPRD_pd Subfamily PTPRD 162-297 1.3e-34 114.8 In-house 133-267 (564) alignment
Range on Protein: 162-297
Range on HMM: 133-267/564.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVY
| .|| |..  .|.|. |.  .... . |. |.| .. .|||.| .| ||. |.||  ||  .....|..|..| . . . . ||.|||||  | |.|..
chkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
. ... ||. |.|..||..|. | .|. ..  | | 
ividamlerikeektvDiyqyvkalrkqRnamVqte

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 162-300 1.5e-33 111.3 In-house 141-279 (298) alignment
Range on Protein: 162-300
Range on HMM: 141-279/298.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVY
. .|| ..   .|.|  |. ||...   .| ||..|. .|.... .| |...|.||  || .. ..||.....|   ||. |  ||.|.||. | ||| .
yhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtf

CSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
. ..  ||. |.| ||||||| | .|...||||.| |  
iaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 162-298 4.6e-31 103.0 In-house 133-270 (319) alignment
Range on Protein: 162-298
Range on HMM: 133-270/319.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSS-SWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| | .. .| .. |. .. .  ..|| ||. ..  .|   . .| .|| |.|| ..| .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.. ....||. | |||.|||.. . .|  ..  | . |
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpe

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 162-299 5.4e-25 82.9 In-house 129-265 (315) alignment
Range on Protein: 162-299
Range on HMM: 129-265/315.0
CYQYWRE--SDIIQYEEYFVKCLSSKDCNGYIERKFavQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRSG
| ||| .  .| ... .. |. || . . . . ||.   . || .| .| ||| |.||  || ..  ..|..| ||    ..    ...||||  | |.|
crqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
| .|.   ..| | . .||||.. | .|. .|  | | | 
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteee

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 162-298 3e-24 80.0 In-house 128-263 (515) alignment
Range on Protein: 162-298
Range on HMM: 128-263/515.0
CYQYWRE--SDIIQYEEYFVKCLSSKDCNGYIERKFAVqlEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGgGPVVVHCSDTVSRSG
| .|| .  .| ... .. |. .| . | | | ||. |   |.. |  | ||. |.||  || .. ...|..| ||   ....   |...|||  | | |
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
|..|.   . . |   .||||.. . .|. .|  | | |
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 162-300 4.6e-22 73.5 In-house 126-265 (281) alignment
Range on Protein: 162-300
Range on HMM: 126-265/281.0
CYQYWRESD-IIQYEEYFVKCLSSKDCNGYIERKFAVqLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
|..|| . .  ..| .. || ..... . |||||| .  ..|. . .| |.. |.||  ||  ... .|.  .|| . ..|    |.|.|||  | |.|.
ChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

YCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLEIH
| ..  ......||   .|| .| ...|...   | |.  .
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

subfamily_PTPRB_pd Subfamily PTPRB 162-298 1.2e-20 68.7 In-house 136-272 (293) alignment
Range on Protein: 162-298
Range on HMM: 136-272/293.0
CYQYWRES-DIIQYEEYFVKCLSSKDCNGYIERKFAVQLekSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQ-QKIGGGPVVVHCSDTVSRSG
| .|| .  . ..| .  |. ..... . .. |.....   .... .| |.. | ||  ||  ...|.|. . .| ... ..   .|.|||||  | |.|
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.. ..   |.. . | .||.| .  ..|...   | | .
tfialdrllqaieeedyvdifgivaelReeRnllvqtek

subfamily_PTPN12_pd Subfamily PTPN12 162-299 5.1e-20 66.5 In-house 125-265 (290) alignment
Range on Protein: 162-299
Range on HMM: 125-265/290.0
CYQYWRES--DIIQYEEYFVKCLSSKDCN-GYIERKFAVQLEksSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRS
| .|| |.  . ....|. |.. . | .. ... | ..|. .  . | .| ||. |.||  || . . ..|..|..| ..|.     |.|||||  | | 
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrt

GVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLEI
|. ... .. |. ||| .   .|||..  ..|. .. .| | | 
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq

subfamily_PTPN23_pd Subfamily PTPN23 162-298 1.2e-19 65.2 In-house 125-267 (288) alignment
Range on Protein: 162-298
Range on HMM: 125-267/288.0
CYQYW--RESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIH---RQQKIGGGPVVVHCSDTVS
. .||  .. .  ..... | . | .. . ..||.. .. ....   .|   |.|.||  ||   | |.||..||| .    .|.    |.|||||  | 
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLE
|.||.. |  |...  | .|..|. || . .|. .   | . |
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

subfamily_PTPN9_pd Subfamily PTPN9 162-294 7.6e-19 62.8 In-house 127-273 (297) alignment
Range on Protein: 162-294
Range on HMM: 127-273/297.0
CYQYWR--ESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ------------KIGGGPV
| |||   | . ... .. |. .. .  . | .|.. ..  | . | .|  ||.. ||  || ..  ..|.|...| ..|             .. | |.
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAV
|||||  . |.| .... |.|.. . .|.|||... | .|  .  ..
vvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi

subfamily_PTPN13_pd Subfamily PTPN13 162-305 4.4e-18 60.5 In-house 119-265 (273) alignment
Range on Protein: 162-305
Range on HMM: 119-265/273.0
CYQYWRES---DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRS
| .|| ||    .  .. . |. |  .. .|.  |..||.  .|. | .| ... ..||  || ...  .||.. || . |.    ||.|||||  . ||
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE--IHYYQAM
|.. .. ..|.  . .  .|| .. ...|. . | | | .  |  |.|.
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 162-297 1.4e-15 51.6 In-house 128-265 (439) alignment
Range on Protein: 162-297
Range on HMM: 128-265/439.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSS--SSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSG
 |.||  .. . | .  |..    .   |. | | |  |. .      ||||. . ||   |  .   ||. .  .   ..|   ||||||||  | |.|
sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
   .. ||||| |.|  ||.  . | .|. .   | .|
tiialdialeqlklenkvdikgivkvlrkqrkqmvqal

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 162-306 1.3e-11 38.7 In-house 136-277 (290) alignment
Range on Protein: 162-306
Range on HMM: 136-277/290.0
CYQYWR--ESDIIQYEEYFVKCLSSKDCNGYI-ERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVihrqqKIGGGPVVVHCSDTVSRS
| ||.   | ... . |. | |  ..| .  |  . ..|.  .|  .  .  ...  ||   |     ..|...  .     .   ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrt

GVYCSVSIALeQCKAEG-VVDVFQVTKSVRRSKPGAVTtLEIHYYQAMD
| . .. ..| |.  .|  .|. .. ...|.|. ..|  ..| |   ..
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvq.vdiqylalve

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 162-296 3.4e-10 34.2 In-house 122-262 (287) alignment
Range on Protein: 162-296
Range on HMM: 122-262/287.0
CYQYWRESDI-IQYEEYFVKCLSSKD--CNgYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIRE----PRTVLQVIDEVIHRQQKIGGGPVVVHCSDT
||.|| | .  ..   | |  |. .    . |  | . .   ..  .  | |... .|| ...        | ||.| . .  ...  . ||.|||..  
cykywPerevPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
. |||.. .. . ... .  | ||| .|   .|  . . | .
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqa

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 174-302 2.1e-13 44.9 In-house 125-250 (267) alignment
Range on Protein: 174-302
Range on HMM: 125-250/267.0
YEEYFVKCLSSKDCNGYIERKFAVQLeKSSSSWNVLQFQVTNWPTDGVIrepRTVLQVI-DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCK
|..  |.    |. | |    . ... |  |. ||  .   .|  .      .  |. .   . . | . |. |.||.||| | ||| .  .   ||. |
yqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnn...kpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

AEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
 |||.|.|.  . .|  ..| | |.| . |
tegvsdifdflrkirsqriglvdtkeryiy

0048179 (Phosphotyrosine protein) phosphatases II 185-299 1.9e-11 39.4 In-house 48-133 (144) alignment
Range on Protein: 185-299
Range on HMM: 48-133/144.0
KdcngyierkfavqleksssswnVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTK
                       ..|.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... .
e......................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleeala

SVRRSKPGAVTTLEI
 ||.  ||||.. . 
lvrsrrpgavpnpgq

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 185-269 3.7e-07 23.8 In-house 197-290 (349) alignment
Range on Protein: 185-269
Range on HMM: 197-290/349.0
KDCNGY-IERKFAVQLeKSSSSWNVLQFQVTNWPTDGVIREPRTVLQV-------IDEVIHR--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALE
|.|.    . . |..| .... . .||.|| ||.  ... .| ..||        ||.   |   ..    ...||||    |.||.. . . |.
knCdlpddddddaill.avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-324 4.6e-15 49.9 In-house 74-205 (440) alignment
Range on Protein: 187-324
Range on HMM: 74-205/440.0
CNGYIERKFAVQLEksssSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSV
 . ||.  .   .|    |  . |..   ||  || .    ||..|..| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . .|.
dsdyinasyingie....srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsm

RRSKPGAVTTLEIhyYQAMDRLLVLPLLIGLLLVLVND
| ..|  | | |   |  .   ..  ||.|  |.| .|
rnnrpqmvqtpeq..yafvheavlegllcgdtliledd

0043147 (Phosphotyrosine protein) phosphatases II 187-302 3.9e-13 45.0 In-house 54-152 (172) alignment
Range on Protein: 187-302
Range on HMM: 54-152/172.0
CngyierkfavQLEKSSSSWNVLQFQVTNWPTDGVIrEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSV
.          .. ..  . ...|.. ..||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . |
l..........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalv

RRSKPGAVTTLEIHYY
|. .||||.. . ...
rekRpgavqnpsqyrf

0048076 (Phosphotyrosine protein) phosphatases II 197-299 8.2e-12 40.5 In-house 36-131 (145) alignment
Range on Protein: 197-299
Range on HMM: 36-131/145.0
VQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKSVRRSKPGAVTT
.  |..  . ...|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  ||||..
ltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpn

LEI
 . 
pgq

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 197-301 6.8e-08 26.9 In-house 167-266 (307) alignment
Range on Protein: 197-301
Range on HMM: 167-266/307.0
VQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQ-CKAEGVVDVFQVTKSVRRSKPGAVT
.... .. |  . ..| .|||  || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. 
lkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq

TlEIHY
| |. |
t.eaqy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 200-296 6.4e-09 29.7 In-house 184-273 (302) alignment
Range on Protein: 200-296
Range on HMM: 184-273/302.0
EKSSSSWNVLQFqvTNWPTDGVIREPRTVLQVIDEVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.|   . ..|.|  . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| .
kkvkktvdilaf..sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 203-270 2.8e-07 24.6 In-house 212-288 (350) alignment
Range on Protein: 203-270
Range on HMM: 212-288/350.0
SSSWNVLQFQVTNWPTDGVIREPRTVLQVID---EVIH------RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQ
|  . |.|.|| ||.  ... .|. .||...   ..|         ..  . |..||||  | | |.....   |..
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsd

PTPc_DSPc_SM00012 208-298 1.9e-20 68.4 In-house 2-94 (105) alignment
Range on Protein: 208-298
Range on HMM: 2-94/105.0
VLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLE
| ....|.||  || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|.|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 209-301 3.1e-06 21.4 In-house 174-261 (288) alignment
Range on Protein: 209-301
Range on HMM: 174-261/288.0
LQFQVTNWPTDGVIREPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHY
 .  . .|. |||  .  . |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .. | ..  |..|   . 
kilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqyl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 212-296 6.2e-06 20.0 In-house 196-275 (310) alignment
Range on Protein: 212-296
Range on HMM: 196-275/310.0
QVTNWPTDGVIREP-RTVLQVIdevIhRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.  |||  ||  |   || | .   .  |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . |
kwpnwpdrgvpdekchtvpqrl...l.aq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqt

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 233-301 1.3e-07 26.0 In-house 124-193 (199) alignment
Range on Protein: 233-301
Range on HMM: 124-193/199.0
DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLEiHY
 || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|. ||
revskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq.hy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 233-301 1.3e-07 26.0 In-house 123-192 (198) alignment
Range on Protein: 233-301
Range on HMM: 123-192/198.0
DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLEiHY
 || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|. ||
revskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq.hy

subfamily_CG42327_pd Subfamily CG42327 243-299 6e-08 26.7 In-house 246-303 (319) alignment
Range on Protein: 243-299
Range on HMM: 246-303/319.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLEI
  ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | | 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeq

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 248-304 2.3e-06 21.9 In-house 2-57 (69) alignment
Range on Protein: 248-304
Range on HMM: 2-57/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTlEIHYYQA
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   || |   
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmn.eieyifi

fn3 Fibronectin type III domain 572-646 3.4e-12 39.5 Pfam-A 2-79 (85) alignment
Range on Protein: 572-646
Range on HMM: 2-79/85.0
APSSLTEVSKTATTITVSWTAL--GSSDADGYVVNVTNDTDT--VQTVQVEGSSNdTLKVEGLEVNTTYSITVRAYQQL
||. |.  . |.|..|.||..   |... .|| | . .....   ....|..... .....||. .|.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 831-917 1.6e-12 40.5 Pfam-A 1-82 (85) alignment
Range on Protein: 831-917
Range on HMM: 1-82/85.0
SPVTSLSVSNVSTTGITVNWTIP-SSDNYVTYYTISYTPSCPQSssVNQTVSVAPHqsttTYSYTLIGLYSGMNYTITVRAGNVLGGS
|... ||||.|..| .|..|. | . .  .|.|.. | ..  ..  . ....| ..    |.|.|| ||  |..|...|.| |  |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt....ttsvtltgLkpgteYefrVqavngageg

fn3 Fibronectin type III domain 936-1012 2.4e-08 27.2 Pfam-A 3-85 (85) alignment
Range on Protein: 936-1012
Range on HMM: 3-85/85.0
PDNVTFIPVNN---NLTWNEVDcsERNGLITGYTVMISNS-----SITYNLTSTERYIILNDLVFGPEYIISVAAVNSVGRGPFS
| |.....|..   .|.|.. .  ...| ||||.|  ...     . ......|..  .|..|  | || ..|.||| .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_PTPN6_pd Subfamily PTPN6 1239-1523 1e-56 187.2 In-house 8-302 (306) alignment
Range on Protein: 1239-1523
Range on HMM: 8-302/306.0
TLPVSMEELGNHVATCHSNGFEEQYKSLYTGE---DKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpNLDMCQREYINANYVHGY--REKRAFIIAQ
..   ..|| ..  . . .||||....| . |     | . |   .||  ||.|||  .|..|..|    . .. . .||||||...    .....| .|
eieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatq

SPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIV-QFEEYFVKCLSSKDCNGYIERKFNIF-TEKGSSSWDVMQFQVTNWPTDGIIRE
  .|.|| |||.|... .   |||.    | |.| |..|| ..|   .. .. |...|.|. . || |....  ..|.... .|.|.. ..||  |. ..
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

PRTVLQVIDEVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
| .||. ...| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. ||||. . | | | .||  .|..|..|.. ...
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk

subfamily_PTPRB_pd Subfamily PTPRB 1240-1519 4.7e-57 188.3 In-house 5-286 (293) alignment
Range on Protein: 1240-1519
Range on HMM: 5-286/293.0
LPVSMEELGNHVATCHS---NGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSP
 |...|.. .||.. ..    .| |.|..|   |.|.....  .. |.| ||..||  || .|. | .    |  . .||||||..||. .| || .| |
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGP

MENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-EIVQFEEYFVKCLSSKDCNGYIERKFNIFTekGSSSWDVMQFQVTNWPTDGIIREPRT
. .|| |||.|. . |.|.||||  . | |.. | .|| .  | |.. .  |. ..... . .. |...|    .... .|.|.. | ||  |.  ...|
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VLQVIDEVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
.|. . .| ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1241-1521 2.8e-102 337.0 In-house 3-286 (305) alignment
Range on Protein: 1241-1521
Range on HMM: 3-286/305.0
PVSMEELGNHV---ATCHSNGFEEQYKSLYTGeDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPME
......| ...    . ...|.|.||||||.  ..|. .| .| ||| ||.|.||..||.|| | ....||  ...||||.||.||..| ..|.||.|..
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIV--QFEEYFVKCLSSKDCNGYIERKFNIFT-EKGSSSWDVMQFQVTNWPTDGIIREPRT
|||.|||..||..||| ||||... |.|...|.||| ||.    .|.|. |.  |.|  ..|||||..| . .. . |  |.|.|.|.|| .|. ... .
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
.|..|..| ..|.|  | |..||||..|.|.||...|.||||..|.|.|||||.|.| .|......|.||||| ......  ...  
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_PTPRD_pd Subfamily PTPRD 1241-1524 2e-79 262.7 In-house 4-287 (564) alignment
Range on Protein: 1241-1524
Range on HMM: 4-287/564.0
PVSMEELGNHVATCHSN---GFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPME
|....|| .|||  ..|    |||.||.. .|.  ...    . ||| ||..||. || .|. | . ..    . .||||....|||...|.| .| |..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQ
.|..|||.|. ....| ||||  .|| |.. | .|| |..  ...|. |.  .... . |. |.|.. ..| |.|  | ||. |.||  |.  .....|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

VIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
.|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. | .|. ..  | | .||. |.|.|  .|.  .| 
lirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1241-1523 5.6e-71 234.2 In-house 4-288 (319) alignment
Range on Protein: 1241-1523
Range on HMM: 4-288/319.0
PVSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPME
.. ..|| ... . .|.|   .|...| | ...... .    |.||  ||..||  ||  |..| . ..  . . .||||... ||.|...|| .|.|.|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSS-SWDVMQFQVTNWPTDGIIREPRTVL
||. |||.|. ....| .|||..  | ..  . .|| | ..... .. |. .. .  ..|| ||... . ..   . .|..|| |.|| ... .. ...|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
... .. . ..|   ||.|||||. | | | .. ....||. | |||.|||.. . .|  ..  | . .||. |||..  ...  .|
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1242-1526 2.5e-69 228.8 In-house 2-288 (318) alignment
Range on Protein: 1242-1526
Range on HMM: 2-288/318.0
VSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSI-GYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSPME
.|.|.| .||.  ...|   ..|.|. |   |... |.   .. ||| ||. ||. ||. |. | .    .  . .||||||. |||.|.|.| ||.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQ
.|..|||.|. . . . ||||  .|| |.. . .|| ...  ....  |.  ...... |. |.|..  .. ..| .| |...|.||  |.  .. ..|.
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
.. .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | |||  ||.|.  .|.   |...
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1243-1524 5e-93 306.1 In-house 3-289 (290) alignment
Range on Protein: 1243-1524
Range on HMM: 3-289/290.0
SMEELGNHVATCHS---NGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVHGYREKRAFIIAQSPMEN
 ....|..||. |.   .||..|.|.| .|| ...  .| ...||  |||.|| |||||||||   ..   |. ||||| |..||.||...|..|.|..|
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKG-SSSWDVMQFQVTNWPTDGIIREPRTVLQ
|..||||.|.. ||..||||.   |.|.. |.||| .|.  ...|. .| |. . .|.|||||...  ..   ..  |.|.|.|||. .| . .| |.|.
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
|| |... | | | ...||||||||.||.|.|.. .....|| |||.||||| || |  ||| |.| .||  |....  ||.  .||
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1243-1525 2.6e-73 241.9 In-house 13-297 (298) alignment
Range on Protein: 1243-1525
Range on HMM: 13-297/298.0
SMEELGNHVATCHSNGFEEQYKSLYTGED----KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSPMEN
 ...| .   . .  |...... | ....    .. ... ...||  ||. .|  .|  |. | ..   .  . .|||| ..|.|... |||..| |...
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPlte

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQV
|| |||.|........||||  .|| ..  . .|| ...  ...|  |. ||...   .| ||...  .| ...  | |...|.||  |. .. ..||..
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYA
...|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| | .|...||||.| .||. |||..  .|.  ....
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_PTPRG_pd Subfamily PTPRG 1243-1517 2.2e-60 199.4 In-house 2-286 (563) alignment
Range on Protein: 1243-1517
Range on HMM: 2-286/563.0
SMEELGNHVATCHSNG---FEEQYKSLY---TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQrEYINANYVHGYREKRAFIIAQSPM
 ..|. .||| .|..|   |.|....|    . .|  ..    ..||  ||  ||. ||  |..|   |. .    .||||||..||. ..|||..| |.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgpl

ENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFT---EKGSS---SWDVMQFQVTNWPTDGIIR
..|. |||.|| . .|. |||.   .|.|.. | .|| . | .....  |.  ...    | .|.. |     .|...      |.|.. |.||  |   
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

EPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMY
 .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| .||  .....   
hslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1243-1514 4.5e-55 181.8 In-house 7-275 (315) alignment
Range on Protein: 1243-1514
Range on HMM: 7-275/315.0
SMEELGNHVAT---CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITL-ITNPNldmCQREYINANYVHGYREKRAFIIAQSPMEN
 ...|  .||       |||...|.|.  |. .   .     ||  ||. ||  ||  |. | ... .    . .|.|||.. ||  || .| ||.|  .
pldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllend...phsdyvnanfidGynkkrryiaaqgpnva

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVqFEEYFVKCLSSKDCNGYIERKFniFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQV
.|.|||... ..... |||| .. |. .. . .|| . ... . .. |   | .  . |  | .   .  |.   .|.|...| ||. |. .   .....
svkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

IDEVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ...||  ||...
irtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_ptpA1_pd Subfamily ptpA1 1243-1476 2e-21 71.2 In-house 9-254 (418) alignment
Range on Protein: 1243-1476
Range on HMM: 9-254/418.0
SMEELGNHVATCHSngFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNpnLDMCQREYINANYVHGYREKrAFIIAQSPMENTVR
|. .| ||.   |    .|... |         | |  . | . ||. ||   .  |. |      |    .||||||. |   |  || .| |. ||. 
siynlknhikcihk..ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidgaypk.qfictqgplpntia

DFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESE-IVQF----------EEYFVKCLS-SKDCNGYIERKfNIFTEKGSSSWDVMQFQVTNWPTDGII
|||.|. . ..  ||||    |. .  | .|| |     ||            | |. .   .| .  |  . ||       . |. |.|   ||   | 
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr.nirltfegetrditqyqyegwpdhnip

REPRTVLQVIDEVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
   . . |..  .  ||..|        |..||||  | |.| .|.  | ..
dhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1244-1526 2.4e-144 474.6 In-house 2-301 (301) alignment
Range on Protein: 1244-1526
Range on HMM: 2-301/301.0
MEELGNHVATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDF
.|.||.|||..|||.||||||.|..||||||..|.||.|||.||||||||||||||.| ..||||.||||||||.|..||.||..||.||.||..|..||
ledlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdf

WKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDC-------------------NGYIERKFNIFTEKgsSSWDVMQFQVTNWP
|..|...|...|||.....|. ...|.|||..||  . |....... ....                   ||||||||.. ..|  |||||.|.|||.||
WrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWp

TDGIIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
.||..|||||||||||.||||||||||||||||||||||||||||||||.|||||||||||||||||.||||||||||||.||.|||.||.|||.|.|||
qdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

AN
||
an

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1244-1527 1.1e-89 295.2 In-house 4-287 (287) alignment
Range on Protein: 1244-1527
Range on HMM: 4-287/287.0
MEELGNHVATCHS---NGFEEQYKSLYT--GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpnldMCQREYINANYVHGYREKRAFIIAQSPMEN
.|..|. ||. |    .||..|.. |     ....  .. ...||  ||...| |.|..|. |        .. .|||| .. ||.||.|||||.||| |
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPmfn

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE-KGSSSWDVMQFQVTNWPTDGIIREPRTVLQ
|.|.|||.| | .|.||||||  .|. .| ||||| |.. | . || .. |. .  .||||||...  . | ..   |.|.|.|||.  | . ||.|.| 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYANF
||.| .. |.| | ...|||||||| ||...|.. .....|| |||.||||| || |  |||.| | .||  |.... .||.  .||..|
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

subfamily_PTPN9_pd Subfamily PTPN9 1244-1517 2.9e-49 162.7 In-house 3-289 (297) alignment
Range on Protein: 1244-1517
Range on HMM: 3-289/297.0
MEELGNHVATCHSNGFEEQYKSLYTGEDK-SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRD
.||| ..|   . .|  ..|. .   . .       .  |   ||....  ||. |..| . .. .  . .|||||.| ||..|.||| .| |...||.|
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsd

FWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVID
||.|. . .|  |||   ..| |.  | |||   | .  .| .. |. .. .  . | .|...|   | . |  |. ||.. ||  |. ..  ..|.|..
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

EVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMY
.| ..|             .. | |.|||||  . |.| .... |.|.. . .|.|||... | .|  .  .. | .||   |  .  |
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1244-1333 1.5e-11 38.3 In-house 7-94 (95) alignment
Range on Protein: 1244-1333
Range on HMM: 7-94/95.0
MEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcqreYINANYVHGYREKRAFIIAQ
.  .  ||   |||    |....||.      . ..| || |   ||| ||  ||  |..| |. . |     |||| .| ||  | ..| ||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyarkncyiaaq

subfamily_PTPRA_pd Subfamily PTPRA 1245-1518 8.9e-61 200.6 In-house 20-295 (330) alignment
Range on Protein: 1245-1518
Range on HMM: 20-295/330.0
EELGNHVATCHSNGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDF
||  .  ..  .. | |....| .|. . .. .   |.||  ||. ||  || .|. | .    .  . .|||| ...||.||  || || | |.|| ||
eeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPkeetvedf

WKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIF----TEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVI
|.|| ..| ..||||   .|  .| |.||| .  .| . .  |.   .. .. |  ||| .     . .  .|  | ||  | ||  |.  ||. .|...
wrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkll

DEVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 .| . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. |..|  .|  | |. ||  ||.|.  | 
kkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1249-1515 1.5e-56 186.6 In-house 13-276 (288) alignment
Range on Protein: 1249-1515
Range on HMM: 13-276/288.0
NHVATCHSNGFEEQYKSL-YTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMI
..      .||.|.|.||   ...|| ..|    |.  ||..||  || .|. |   .. .  . .||||.|..|...|...| .|.|. .|| |||...
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWelv

VDYKVSAIVMLCGTEEDGQECCYQYWRESEI-VQFEEYFVKCLSSKDCNGYIERKFNIFteKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQ
 ..|.| |||| .  |.|.. | .|| ...  ... .  |. ..||. . ...||. .   |  .  .. |.| . || .|. .  . .|.... |   .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

QKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS
|.   ||..||||. | |.|.. ..  .... ..| ..||. . . .|....  | || ||  ||||. 
qad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPRK_pd Subfamily PTPRK 1251-1514 1.9e-60 199.4 In-house 16-273 (314) alignment
Range on Protein: 1251-1514
Range on HMM: 16-273/314.0
VATCHSNGFEEQYKSLYTGedksCSIGYSEDNKAFNRFKNITVYDDNRITLITNpnLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDY
. .... || |.|.||. |          ..|.. ||...|  ||  |..|||    .  . .||||... .|.  .|||..| |...||.|||... |.
lkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KVSAIVMLCGTEEDGQECCYQYWRESEIVqFEEYFVKCLSSKDCNGYIERKFNIFT-EKGS-SSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQK
. ..||||    | |.  |..|| |   | ...  |......  . .. | |..   ..|      | ||| ..||. ..  . ...|... .| . |..
ncasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee

iGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
 . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | .||  ||.||
.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

0040438 (Phosphotyrosine protein) phosphatases II 1252-1524 6.2e-76 251.0 In-house 13-282 (317) alignment
Range on Protein: 1252-1524
Range on HMM: 13-282/317.0
ATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYK
     ....|... |..    ..|... ..|| .||...|  ||..|. |   ..       ||||.||.|...||.||..|.|..||| |||.|. ...
lksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

VSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkiG-
|. ||||. .||.|.| |.||| . | .......|..|| . ..|.. |.. .   ..| |  |..|. |.|| .|.   |...|. ...| . ..  . 
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dp

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
||||.||||. |.|.|... . ..|||.. || |||... | .|. .||||.|..||  .|... .||| . |.
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl

0043336 (Phosphotyrosine protein) phosphatases II 1253-1518 6.8e-72 237.5 In-house 16-277 (278) alignment
Range on Protein: 1253-1518
Range on HMM: 16-277/278.0
TCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKV
     ........|..    ..||.....|| .||.|.|  || .|. |   ..       ||||.|| ||. .|.||..| |...|| |||.|. ...|
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

SAIVMLCGTEEDGQECCYQYWReSEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkIGGG
. ||||.. .|.|.. |.|||  .. .......|..|. . ...|. |....   . . |  |.... ..|| .|.   . ..|. . .|.....   .|
ttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
||.||||. |.|.|... . ..||| . || ||.... | .|. .||||.|..||  .||.. .||
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1254-1523 1.8e-56 186.3 In-house 16-282 (315) alignment
Range on Protein: 1254-1523
Range on HMM: 16-282/315.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLIT-NpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKV
 |.  | |... |   .     ..  ..|   ||.|||  .| .|. |   .   |  ...|||| |.... . .|.| .| | . .| |||.|....||
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid...dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

SAIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSSKDCNGYIERKFniFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRqQKIG
..|||.   .|. .  | ||| .  .. |.| .. |. || . . . . ||.   | |. .|  | ||| |.||  |. ..  ..|..| ||    ..  
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkk

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
  ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | ..|. ||...  .|. . |
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1254-1518 7.2e-55 181.4 In-house 20-288 (325) alignment
Range on Protein: 1254-1518
Range on HMM: 20-288/325.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
   .||  ... | . . ..  .    .||| |||||.  .| .|. | |    |  . .||||.|.. ...|  |. ||.|. .|. |.|....|.. |
qdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs

AIVMLcGTEEDGQECCYQYWRES--EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI--
 .|.|    . |.. | .|| .   . ..|    ||  . ..   |. |....   |.  .  | |||.  |.  |  . | |.. ... | . ....  
vvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

---GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
   . .|..||||. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | |||. ||| .  ..
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1254-1516 2.9e-39 129.6 In-house 17-234 (392) alignment
Range on Protein: 1254-1516
Range on HMM: 17-234/392.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLIT-NpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKV
 ||  | |... |   .    ...  |.|.  ||.|||  || .|. |   .   |. ...|.|| |....  ..|.| .|.|   .. |||.|. . .|
rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid...dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

SAIVMLCGTEEDGqeccyqywreseivqfeeyfvkclsskdcngyierkfnifteKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIgGG
..|.|.   .|                                            || .   | ||..|.|| ... .   ..|..| ||     .    
ttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.th

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
|...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | .||. ||  .  
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

0039614 (Phosphotyrosine protein) phosphatases II 1255-1521 2.6e-72 239.1 In-house 30-292 (297) alignment
Range on Protein: 1255-1521
Range on HMM: 30-292/297.0
HSNGFEEQYKSLYTGEDKsCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMcQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVS
 ..........|.   .  .||.... || .||.|.|  ||..|. | .... |.    ||||.|| ||.  .|.||..| |...|| |||.|. ...|.
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

AIVMLCGTEEDGQeCCYQYWRESEIvQFEEYFVKCLSSKDCNGYIERKFNIFTekGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGG
.||||. ..|.|. .|.||| |..  ......|..|. . ..||. |....    .. |  |..||.|.|| .|.   ....|.....| .....  .||
vivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkgg

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
||.||||. |.|.|...   ..|||.. || |||... | .|. .||||.|..||  .|... ..|| .
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1255-1519 1.8e-57 189.6 In-house 13-277 (281) alignment
Range on Protein: 1255-1519
Range on HMM: 13-277/281.0
HSNGFEEQYKSLYT-GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
...|| |.|..|.  | |.. .  ....|.  ||..||. ||  |...  | .    . .|||||.| ||......|..|.|. ... .||.|....|||
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

AIVMLCGTEEDGQECCYQYWRESE-IVQFEEYFVKCLSSKDCNGYIERKFNIfTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGG
||||.    | |.  |..|| . .  ... .. || ..... . ||||||.. ..... . .| |.. |.||  |.  ... .|.  .|| . ..|    
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|.|.|||  | |.|.| ..  ......||   .|| .| ...|...   | |. ||. .| ..  .|.
plvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1255-1523 6.7e-54 177.8 In-house 16-281 (515) alignment
Range on Protein: 1255-1523
Range on HMM: 16-281/515.0
HSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITL-ITNpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
|   | |... |   .    ..   | |   ||.|||  || .|. | . |   |  . .|.|| |....   .|.| .| | . .| |||.......|.
httlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin...dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

AIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSSKDCNGYIERKFNIFteKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGg
.|.|.   .|. .  | .|| .  .. |.| .. |. .| . | | | ||...   ||. |  | ||. |.||  |. .. ...|..| ||   ....  
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.

GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
 |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | .||. ||...  .|.   |
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt

0051299 (Phosphotyrosine protein) phosphatases II 1256-1519 7.7e-76 250.6 In-house 22-287 (288) alignment
Range on Protein: 1256-1519
Range on HMM: 22-287/288.0
SNGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSA
 .|..|... |.    | ..|... . |.  ||...|  ||..|. | . ..  .    ||||.|..||. ||.||..| |..||| |||.|. ...|. 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

IVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE----KGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkIG
||||....|.|.| |.||| ... .......|..|| . ...|. |.. .       ... |  |..|..|||| .|.   |. .|. . .|.. ..  |
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sg

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|||||||||. |.|.|... . ..||| ..||.|||... | .|. .||.|.|..||  .||.. .|||
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk

0045450 (Phosphotyrosine protein) phosphatases II 1256-1518 7.4e-71 234.7 In-house 26-304 (307) alignment
Range on Protein: 1256-1518
Range on HMM: 26-304/307.0
SNGFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdMCQREYINANYV--------HGYREKRAFIIAQSPMENTVRDFW
 .|.......|.  ...   ..||.... || .||.|.|  ||..|. | . ..  .    ||||.||        .||. ||.||..|.|...|| |||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

KMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-EIVQFEEYFVKCLSSKDCNGYIERKFNIFTE-KGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEV
.|. ...|..||||....|.|.| |.||| .. | .......|..|| . ..||. |....    . . |  |..|. |.|| .|.   . ..|. |.||
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

IHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 . ...  .||||.||||. |.|.|...   ..|.| ..||.   ||.... | .|. .||||....||  .||.. ..|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Ptp69D_pd Subfamily Ptp69D 1256-1519 3.4e-67 221.7 In-house 21-287 (307) alignment
Range on Protein: 1256-1519
Range on HMM: 21-287/307.0
SNGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSA
  |... |..|  .  |||....  ..|.  ||...|. .|..|. | . .  .  . .||||....||.||. ||.|| |.|.|. |||.|| . .|  
dfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGS-----SSWDVMQFQVTNWPtDGII-REPRTVLQVIDEVIHRQQK
||||   .|  .. | .|| . ..||...  ||. |.. .. ||.|.... . | .      |  |.|.. |.|. | .. . .|..|..|..| . ...
ivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

IgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. |.||. .|  .  | .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

0050432 (Phosphotyrosine protein) phosphatases II 1257-1526 6.5e-78 257.5 In-house 42-307 (308) alignment
Range on Protein: 1257-1526
Range on HMM: 42-307/308.0
NGFEEQYKSLYTGED-KSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDmCQREYINANYVHGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVS
 ..||... |.   .  ..|... ..|| .||.|.|  || .|. |      |     ||||.||.||  . .|.||..|.|..||| |||.|. ...|.
glleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

AIVMLCGTEEDGQECCYQYWRES---EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqkiG
 ||||. ..|.|.| |.||| ..   ...... ..|..|| . ...|. |.. .   ... |  |..|. |||| .|.  .|. .|. ...| ...   .
vIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...p

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
|||.|||||. |.|.|... . ..||| ..|| ||||.. | .|. .||.|.|..||  .|... .||||. |..|
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1257-1514 9.2e-55 180.5 In-house 9-262 (283) alignment
Range on Protein: 1257-1514
Range on HMM: 9-262/283.0
NGFEEQYKSLYTgEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmcqrEYINANYVH---GYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
. | |..| |    |... |  ...|| .||...| ..| .|. | ....      .|||| ..     |.... .||||||...||.|||||. | |..
klfrevlkrlsv.pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

AIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE-KGSSSWDVMQFQVTNWptdgIIREPRTV---LQVIDEVIHRQQKI
|||||    || .. | ||| .   ... |. |        | .| ... . ..    |.  .  .|| .|    .  .. ..   |  .. ||  |.. 
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqtes

GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
  ||.||||| .. |..|....| .... ..| |||||.| | .|  ...|| |||||  ..|..
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1257-1375 2.7e-18 60.6 In-house 27-142 (310) alignment
Range on Protein: 1257-1375
Range on HMM: 27-142/310.0
NGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIV
.|.  ||. | . .| | .    ...   ||. .. . |. |. |  .        .|| ||||.    . .|| .| |.. |. |||.|| . .  .|.
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLCGTEEDGQECCYQYWRE
.|| . |.|.  |  ||  
llckvgeegrpkcvgywps

0046845 (Phosphotyrosine protein) phosphatases II 1258-1526 3.5e-74 245.0 In-house 1-282 (284) alignment
Range on Protein: 1258-1526
Range on HMM: 1-282/284.0
GFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNlDMCQREYINANYVHGY-----REKRAFIIAQSPMENTVRDFWKMIVD
|.||... |.    |   |.|... . |.  ||.|.| .||..|. | . .. |.   .||||.||.||     . |..||..| |..||| |||.|. .
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

YKVSAIVMLCGTEEDGQECCYQYWRESE-IVQFEEYFVKCLSSKDCNGYIERKFNIFTEK-GSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQ
..|. ||||....|.|.| |.||| ...  .......|..|| . ...|. |.. .  .. .. |  |..|..|.|| .|.  .|. .|. ...| . ..
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

K-IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
.  ||||.|||||. |.|.|... . ..||| ..||   .|||... | .|. .||.|.||.||  .||.. .||||. |...
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle

subfamily_PTPN23_pd Subfamily PTPN23 1258-1516 2.6e-45 149.5 In-house 16-278 (288) alignment
Range on Protein: 1258-1516
Range on HMM: 16-278/288.0
GFEEQYKSLYTGED---KSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpnldMCQREYINANYVHGYREK-RAFIIAQSPMENTVRDFWKMIVDYKVS
......| | . .|   .. ||  .. .   ||...|  || ||..|         . .|||| .|..       ||..|.|...|. |||.|... |.|
aldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

AIVMLCGTEEDGQECCYQYWR--ESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIH---RQQK
 ||||   || |.. . .||   . | |.|... | . | .. . ..||.... |.. .   .|.  |.|.||  |.   | |.||..||| .    .|.
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

IGGGPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
    |.|||||  | |.||.. |  |...  | .|..|. || . .|. .   | . .|.   ||..  
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

DSPc_SM00195 1259-1518 3.4e-70 231.8 In-house 2-262 (263) alignment
Range on Protein: 1259-1518
Range on HMM: 2-262/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVM
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. |...|...|..| |...||.|||.|... ||. |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGTEEDGQECCYQYWRES--EIVQFEEYFVKCLSSKDCN-GYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIgGGPV
|.  ||.|.| |..|| |.  .  .|... ||. . . ..  .| |....  |. . . .| |.|..|||  |.  ... ||... .| ......  ||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.||.||. |||.|  |.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1259-1518 3.4e-70 231.8 In-house 2-262 (263) alignment
Range on Protein: 1259-1518
Range on HMM: 2-262/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVM
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. |...|...|..| |...||.|||.|... ||. |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGTEEDGQECCYQYWRES--EIVQFEEYFVKCLSSKDCN-GYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIgGGPV
|.  ||.|.| |..|| |.  .  .|... ||. . . ..  .| |....  |. . . .| |.|..|||  |.  ... ||... .| ......  ||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.||.||. |||.|  |.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1259-1516 1.6e-38 127.3 In-house 22-277 (439) alignment
Range on Protein: 1259-1516
Range on HMM: 22-277/439.0
FEEQYKSLYTGE-DKSC--SIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAI
|.| .... . . | .|  |.   | ... ||.|... .|  |.||   | .   .  ||||||..|| ... .| .| | ..|. |||..... |.. |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMLCGTEEdgqecCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSS--SWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGGP
|||.   |      |.||  .. | . .  |..    .   |. | |..| |. ..     |.||. . ||   .  .   ||. .  .   ..|   ||
vmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
||||||  | |.|   .. ||||| |.|  ||.  . | .|. .   | .| ||  ||. .  
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1259-1518 3.8e-08 26.3 In-house 43-309 (346) alignment
Range on Protein: 1259-1518
Range on HMM: 43-309/346.0
FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKN--ITVYDDNRITLITNPNLDMCQREYINA--NYVHGYREKRAFIIAQSP-MEN--TVRDFWKMIVDYK
  |....    . ..|   | |.   .||  .  .   . . |||        |   |..    |.  .. .. .|.|| | |||   | ||| || . .
ttedfeankvrnregcpkiydenrvqlnrpghedvnyinasvitlkdvsrrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeq

VSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGY-IERKFNIFTEKGSSSWdVmqFQVTN-WPTDGIIREPRT--VLQVIDEVIHRQQ
.  . ..   .   .     .  |    |.   ..      |  |   |   ... |  | |  .   ||    |   . . |.|  ....| .    .|
ihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsv.i..cqvhhhapwkhlqqppktlpiikmihqflsekq

KIGGGPVVVhCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
    |  ||       |.  .     |..|       ..... |.... .||.| .. ||.||| ..  |.
vqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

0047943 (Phosphotyrosine protein) phosphatases II 1261-1518 3.2e-73 241.9 In-house 16-272 (273) alignment
Range on Protein: 1261-1518
Range on HMM: 16-272/273.0
EQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC
|... |.    . ..|... ..|| .||.|.|  ||..|. |      ..    ||||.|| ||. ||.||..| |..||| |||.|. ...|. ||||.
eefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

GTEEDGQECCYQYWRESE---IVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVV
 ..|.|.| |.||| ...    .......|..|| . ...|. |.. .   . . |  |..|..|.|| .|.   .  .|. |..| . .... ..||||
elvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvv

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
||||. |.|.|... . ..|.| ..|| |||... | .|. .||.|.|..||  .||.. .||
VHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPN3_pd Subfamily PTPN3 1261-1514 2.3e-47 156.3 In-house 19-271 (280) alignment
Range on Protein: 1261-1514
Range on HMM: 19-271/280.0
EQYKSLYTG-EDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNlDmcqreYINANYV----HGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAI
 |.. ||   .. ..|.    .| . ||...|. ||. |..|  ... |     |||||||     .      .|..| |...|. |||.|. . |.| |
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.d.....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMLCGTEEDGQECCYQYWRE-SEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEViHRQQKIGGGPV
|||  . |.|.  |.||| | .. ... |. ||| ...  . |. |.. .  .. . .  ..|.| ..||  |.  ..  .|.....| .....    ||
vmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePv

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|||||  . |.||.  . .||    |.  | . .. . .|  .   | | .||  . | |
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1262-1429 3.9e-23 76.8 In-house 12-180 (297) alignment
Range on Protein: 1262-1429
Range on HMM: 12-180/297.0
QYKSLYTgEDKSCSIGYSEDNKA--FNRFKNITVYDDNRITLITNPnldmCQREYINANYVHGYREKR--AFIIAQSPMENTVRDFWKMIVDYKVSAIVM
.. .|.  | .. |   .  | .   ||...|  .||.|. |   .     .|.||||.||    |.    .|.|| |...|| |||.....  | .|||
ekdllld.eargesfssakrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivm

LCGTEEDGQECCYQYWRESE--IVQFEEYFVKCLSSK--DCNGYIERKFNIFTEkgSSSWDVMQFQVTNWPTDGII
..  .|||.. |. || ...    .  .. |. |||   . .  |  .....    | |  |   |  .||  |. 
vaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvp

0045098 (Phosphotyrosine protein) phosphatases II 1263-1519 3.1e-64 212.4 In-house 14-273 (278) alignment
Range on Protein: 1263-1519
Range on HMM: 14-273/278.0
YKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITlitnpnldmcqrEYINANYVHGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
.  | .|   ... .  ..|...||.|.|  || .|.             .||||.|..||  ...||..| |...|| |||.|. ......||||.. .
efllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE----KGSSSWDVMQFQVTNWPTDGIIREP--RTVLQVIDEVIHRQQK--------
|.|.| |.||| |.. .......|..|| . .. |. |....       ..  |. | ... ..||  |.  .|  . .|...... .....        
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

----IGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLDQYSSIYEVISMYLK
     .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..|.||  .||.. ..|.
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_CG7180_pd Subfamily CG7180 1263-1518 1.5e-48 159.9 In-house 23-290 (296) alignment
Range on Protein: 1263-1518
Range on HMM: 23-290/296.0
YKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
.|   . |   |  |. ..|.  ||  ..  || ||. | .    .  .  |||| || ..  |...|. . |...|| .||... | ..||.|.|. | 
lkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktf

EDGQeCCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE--------K--GSSSWDVMQFQVTNWPT-DGIIREPRTVLQVIDEVIHRQQKI--
.  .  . .|| .    |. | ||. ...|       |.| .  .        |        |..||.| |.  | .     ......  |   ..|.  
dfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvde

--GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
    |||||..|| .||||||... ..||. . |. ||||.  | .|||.|. | . ..|  ||.|.. ..
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_PTPRN_pd Subfamily PTPRN 1263-1514 5.3e-36 118.8 In-house 35-288 (297) alignment
Range on Protein: 1263-1514
Range on HMM: 35-288/297.0
YKSL--YTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC
...|  |  |....... .|.|   || |..  ||..|..| .. .    . .||||  .      . |.| .|.|. .|| |||.|. .  |  ||.|.
wealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas..aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

GTEEDGQECCYQYWRESEIVQFEEYFVKCLSSK-DCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIhRQQKIGGGPVVVHC
  ||.| . |..|| .     .. | |. .| .  |. |. | | .   . | .  | ||    ||  |.  .....|.    |  .  .    |.||||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhc

SDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|| . |.|||. . . |..  |    .|.    . .|  .|| | | ||.  .. ..
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1264-1520 1.8e-49 163.2 In-house 2-266 (270) alignment
Range on Protein: 1264-1520
Range on HMM: 2-266/270.0
KSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
| |  .| .. ..     .|..||...|      |..|  ..  .  . .|||||||.|. . |...| |..|...|...||.||.. ||.||||. | |
keldkeetsesdlpeaargkklnRyadiLPsPatRvrl..eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EDGQECCYQYWRES--EIVQFEEYFVKCLSSK--DCNGYIERKFNIFtEKGSSSwDVMQFQVTNWPTDGIIREPR------TVLQVIDEV-IHRQQKIGG
|.|.. | .|| ..  | |..|. ..| |...    .||| .. ..  |||..   .. |. ..|| .|. ||.        .|... .|  .....  .
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
.|..||||. | |.|.   . ||..  . .. ||| .. . .|. ..  | . .||  .|.....| . 
ePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

0049772 (Phosphotyrosine protein) phosphatases II 1266-1520 2.6e-31 104.9 In-house 30-282 (314) alignment
Range on Protein: 1266-1520
Range on HMM: 30-282/314.0
LYTGEDKSCSIGYSEDNKAFNRFKNITVYDdNRITLitnPNLDMCQREYINANYVHGYrekRAFIIAQSPMENTVRDF----------WKMIV--DYKVS
| .  .... ... . |.  ||...|  .| ||  |   |.|..    ||||.||.|.   ..||..| |.|.|| ||          |.|..  |..| 
lsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvr

AIVM---------------------LCGTEEDGqeccyQYWRESEIVQFEeyfvkclsskdcngyierkfNIFTEKGSSSWDVMQFQVTNWPTdGIIREP
 |||                     |..  . |      .. .... ...                    .. ...   .  ....  ...|  |    .
divmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvpD.gsapll

RTVLQVIDEVIHRqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTLDQYSSIYEVISMYLKL
. ...... .        ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|.||  |.|.. .||| 
edfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_PTPN14_pd Subfamily PTPN14 1268-1519 7.1e-44 145.0 In-house 35-297 (300) alignment
Range on Protein: 1268-1519
Range on HMM: 35-297/300.0
TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmcQREYINANYVHG--YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDG
  ||  .| .  ..|.  ||||..  |.|||. |... .    . .||||  ..     ..| .|.||.|.|.||.|||.|. . .|. ||||  .||||
kredallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedg

QECCYQYWRES----EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVI----HRQQKI----GGGP
.| ...|. ..    . |.|... |    |.| . .| .....     .   .|. .| |.|| .|. ..... |. ..||     . ....       |
keksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||  .|.|.  |||
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1270-1517 6.6e-40 131.8 In-house 21-258 (267) alignment
Range on Protein: 1270-1517
Range on HMM: 21-258/267.0
EDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmcqreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECC
.   .|  ..|.|...||. .   |||.|. | |. .       |||| ||.||. |.|||. | |..||. ||...| |.||. ||.|  . .|     
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf

YQyWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIfTEKGSSSWDVMQFQVTNWPTDGiirEPRTVLQVIDEV-IHRQQKIGGGPVVVHCSDTVSRSGVY
.   .  .  ....  |.    |. | |    ...   |  |. .|  .   .|  .    . .  |. .  .  . | . |. |.||.||| | ||| .
wP.Pkmgqakkyqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf

CSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMY
  .   ||. | |||.|.|.  . .|  ..| | |...|  |.|... |
lvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0036941 (Phosphotyrosine protein) phosphatases II 1271-1523 8e-75 247.2 In-house 28-282 (297) alignment
Range on Protein: 1271-1523
Range on HMM: 28-282/297.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCY
. |.|.. ...|.  ||.|.|  ||..|. |      |     ||||.|| ||. ||.||..| |..||| |||.|. ...|. ||||.  .|.| | |.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWRES--EIVQFEEYFVKCLSSKD--CNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRS
||| .   | .......|..|| .   ...|. |.. .   ... |  |..|..|.|| .|.   |...|. |..| ...... .||||.||||. |.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
|... . ..|.| .    || ||.... |..|. .||||.||.||  .||.. ..|| . |
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

subfamily_PTPN13_pd Subfamily PTPN13 1271-1519 2.8e-42 139.9 In-house 26-270 (273) alignment
Range on Protein: 1271-1519
Range on HMM: 26-270/273.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmcqreYINANYVHGYR--EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQEC
 ..|..| ...||. ||..|.  ||. |..|  . .       ||||....     ..  .|..| |. .||.|||.|. . |.. |.|.    |.|.  
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CYQYWRESEI--VQFEE-YFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRS
| .|| ||.   .. .. . |. |  .. .|.  |....   . . | .|.... ..||  |. ...  .||.. || . |.    ||.|||||  . ||
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|.. .. ..|.  . .  .|| .. ...|. . | | | |||  .|..|   ||
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPN1_pd Subfamily PTPN1 1271-1512 6.5e-40 131.7 In-house 21-265 (290) alignment
Range on Protein: 1271-1512
Range on HMM: 21-265/290.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmcqrEYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCY
| ...    . |.. ||..... ||  ||.|  . |      .||||. |.  . || .|..| |. |||  ||.|. . |  |.|||    | .|  |.
dfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWRES---EIVQFE--EYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQ-KIGGGPVVVHCSDTVSR
||| .    . ...|  .. || .| .. . |. |....   |   . ....|  | ||  |. . | . |. . .| .    .   ||.|.|||  . |
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

SGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYE
|| .| |   | . ....    ||. .|   .|. . | . | ||    | 
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1271-1523 2.2e-19 64.0 In-house 43-290 (302) alignment
Range on Protein: 1271-1523
Range on HMM: 43-290/302.0
DKsCSIgySEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTV---RDFWKMIVDYKVSAIVMLCGTEEDGQe
.| |..    .| ..|. ... ..|.|.. |      .... .|.||  |.    .|  |.|| |  ...    .||.|. . |.  .|.| |.||  . 
ek.Cka..fkknlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.

CCYQYWR--ESEIVQFEEYFVKCLSSKDCNGYI-ERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSR
   ...     . ..... ||     .  ..   .    .. |  | |  ..   .|||. . .  .  .. . . .| . ..  .  ..|.     . |
tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
 |.  .. .|.|. ...  . . .. ||.|  .| || .|.|| |.| .. .|.| . |
agafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt

subfamily_PTPN12_pd Subfamily PTPN12 1272-1519 7.6e-53 174.3 In-house 30-278 (290) alignment
Range on Protein: 1272-1519
Range on HMM: 30-278/290.0
KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQ
 | . | .| |.. ||.|.|  || .|..| .. . .  . .|||||...|  .| ..| ||.|. .|. |||.|| ...|. .||.|   | |.  | .
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWRES--EIVQFEEYFVKCLSSKDCN-GYIERKFNIFTEkgSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRSGVY
|| |.  | ..|.|. |.. . | .. ... | ... ..  . |  | ||. |.||  |. . . ..|..|..| ..|.     |.|||||  | | |. 
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGti

CSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
... .. |. ||| .   .|||..  ..|. .. .| | .||. .|. .  ...
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_egg_pd Subfamily egg 1272-1519 3.9e-21 70.0 In-house 30-271 (307) alignment
Range on Protein: 1272-1519
Range on HMM: 30-271/307.0
KSCSIGYSEDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgqECCYQ
.|    .|..|.   | | .   |  |..|  . .  .   ..| ||.|.|      ||.||.|. ||| |||.|.   .|  ||||  . |   | |  
islttaasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWRE--SEIVQF--EEYFVKCLSSKDCNGYIerkFNIFTEKGsSSWDVMQFQVTNWPTDgiIREPRTVLQVIDevIHRQQKIGGGPVVVHCSDTVSRSGV
||    |. ...    . ...|  ..    .   |..   |     |  .  .  |  |  ...   |   .   . |. .    ||||.. . ||....
ywpkaesdslvtvpGslrienlkvdskadpl...frvtklkl.vGgddeerflehwqgd..vnnssdvysplr..vlrklrnlskpvvvqdilGvskaat

YCSVSIALEQCKAEGVV--DVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
  .. ||| .     ..   | .  . .|. .. .| .  .|  .| .. ....
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

0040439 (Phosphotyrosine protein) phosphatases II 1273-1518 3.5e-67 221.9 In-house 2-246 (249) alignment
Range on Protein: 1273-1518
Range on HMM: 2-246/249.0
SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQY
..|... . ||  ||...|  || .|. |   |.|  .   ||||.|..||. ||.||..| |...|| |||.|. ......||||. ..| |.| |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
| ... .......|..|| . ...|. |.. .   . ..|  |...|.|.|| .|.   . ..|. |..| . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 ..||| . |. ||.... | .|. .||||....||  .||.. ..|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 1274-1518 9e-65 213.8 In-house 1-243 (245) alignment
Range on Protein: 1274-1518
Range on HMM: 1-243/245.0
CSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW
.|... . || .||...|  ||..|. |   ..   .   ||||.||.||| .. ||..| |...|| |||.|. ......||||. .||.|.. |.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

RESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
 ..|........|..|| . ...|. |....  .. . |  |.... ..|| .|.   ....|.....| . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
.||| ..|. |..... | .|. .||||.|..||  .||.. ..|
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 1274-1518 9.6e-56 184.4 In-house 2-242 (243) alignment
Range on Protein: 1274-1518
Range on HMM: 2-242/243.0
CSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMcqREYINANYVHGYreKRaFIIAQSPMENTVRD----FWKMIVDYKVSAIVMLCGTEEDGQECC
.||. .. |.  ||...|  ||..|. |      .     |||||.. ..  .| .|. | |...|| |    ||.|. ......||||. ..| |.| |
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

YQYWReSEIvQFEEYFVKCLSSKDCNGYIERKFNIFTEK-GSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQK-------IGGGPVVVHCSDT
.|||  .|. ......|..||.. ...|. |.. .   . .  .. |.... ..||  |.  .|  .|. .|||.  ...        .||||.||||  
aqywp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VSRSGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLDQYSSIYEVISMYL
|.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .||.. ..|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1274-1514 9.7e-28 91.6 In-house 29-265 (281) alignment
Range on Protein: 1274-1514
Range on HMM: 29-265/281.0
CSIGYSEDNKAFNRFKNITVYDDNRITLIT-NPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQY
|..     |.  ||. || . |  |. |    || .    .|| |||..    || .|..| | ..|  |||.|| . . .||||||   |  .| | .|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WRE-S-EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEkGSsSWDVMQFQVTNWPTDGIIREPRTVLQVIdevihRQQKIGGGPVVVHCSDTVSRSGVYCS
.   .   .||... |.   |   .  .  ..|.  | |  .  . ..   .||   .      .|...     |. .    | |.|||  | |||   .
fprnahcclqfdklsvsyedstvnkslvttrlnlsye.ge.trlithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlma

VSIALEQCKAE-GVVDVFQVTKSVRRS-KPGAVTTLDQYSSIYEVI
| |||.  ..   . |. |.   .| . .  .| ||.||  |..|.
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1274-1518 1.9e-21 71.3 In-house 27-270 (285) alignment
Range on Protein: 1274-1518
Range on HMM: 27-270/285.0
CSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHG-YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQY
|.    | |  .||. .. . .. |. |         .|.|| |....   ... ..| .| |. .|. |||.|| . |.. ..|||   | | | |  |
ctytayeanpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WRE--SEIVQFEEYFVKCLSSKD--CNGYIERKFN-IFTEKGSSSWDVM-QFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSG
. |   |.|.| .| .     |.    | |   .  | ||  ||    | . ||  || .    . | ....   | . . |    |..||||  | |. 
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrta

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 .  .  |  .   .  ...... . .|  .  || .  |.  .| |.  |.
tfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1274-1362 6.7e-11 36.3 In-house 29-120 (347) alignment
Range on Protein: 1274-1362
Range on HMM: 29-120/347.0
CSIGYSEDNKAFNRFKNITVYDDNRITLItNPNLDMCQ----REYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
..    | . . || |.  . |. |. |    . ....      |||| ...    .. .|..| |. .||||||||.   ||. .| .    
ftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1276-1525 1.6e-65 215.8 In-house 3-249 (250) alignment
Range on Protein: 1276-1525
Range on HMM: 3-249/250.0
IGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQEcCYQYWRE
..   .||  ||. .|  .|  |. | ..   .  . .|||| ..|||.|..|||..|.|...|. |||.|....|...||||   .| ... . |||  
vakkpqnkeknryadiialdssrvvLekekgdk..esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIAL
 .  .. .  |. ||..    |. ||. .  .| ...  | |.. ..||  |. .. ..||.....|   ||..| .||.|.||  |.||| .. ..  |
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYA
|. | | |||||.| | .|. .|.||..|.||...||.|  .|.  . ||
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1280-1515 9.7e-49 161.4 In-house 59-288 (319) alignment
Range on Protein: 1280-1515
Range on HMM: 59-288/319.0
EDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgQECCYQYWRESEIV
..||  ||. ||  .| |.. |  ..   .   .|||| .| ||. |  .| || |..||. |||.|| .|..|.||.|       .. | |||     .
dqnkdknriinilafdknvvkl..erliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

QFEEYFVKCLSSKDCNGYIERKFNIFT-EKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQ
. |.. ||  | .... |. |....    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |.|||  . . |..
keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldr

CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS
 | |  |||... . .|. ..  |  | ||  ||  . 
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1280-1515 1.7e-48 160.6 In-house 23-252 (284) alignment
Range on Protein: 1280-1515
Range on HMM: 23-252/284.0
EDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgQECCYQYWRESEIV
..||  ||. .|  .| |.. |  ..   .   .|||| .. ||. |  .| .| |..||. |||.|| .|..|.||.|       .. | |||     .
dqnkdknrighilafdknvvkl..erliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

QFEEYFVKCLSSKDCNGYIERKFNIFT-EKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQ
. |.. ||  | .... |. |....    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |.|||  . . |..
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS
 | |  |||... . .|. ..  |  | ||  ||  . 
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1280-1525 9.5e-28 92.1 In-house 39-286 (307) alignment
Range on Protein: 1280-1525
Range on HMM: 39-286/307.0
EDNKAFNRFKNITVYDDNRITLITnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESE--
. |   ||.... . | .|| . .    |    .|| |||.    . . || || |.|||. .|| |... || ...||| . | ..  | |||   |  
santdknryqdvkcqdkgrivvkf....dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

IVQFEE----YFVKCLSSKDCNGyIERKFNIF---TEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqkiggGPVVVHCSDTVSRSGVYCS
   | |      |. | .|      |   |.     . .. |  . ..| .|||  |. .   | . ... |   .      |||||||  | |||   .
klvfgeapntisvanlgakklap.dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtiva

VSIALEQ-CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS-MYLKLH-STYA
.|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.   .|.|.  ||.
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1281-1514 1.3e-38 127.5 In-house 2-235 (237) alignment
Range on Protein: 1281-1514
Range on HMM: 2-235/237.0
DNKAFNRFKNITVYDDNRITLITNPNLdmcqREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEI-
.||. ||. ||..|| .|. |  . .      .||||.|..|.    . .| || |.|..  |||.|. . | | |||| |  |  .. |..|| ...  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

VQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWD-VMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALE
  .  . |     ..   |  | . ....        . |.| | ||  |. ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|.| . |||...  .|.   .|  . | |||  |...|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1281-1521 3.1e-26 87.1 In-house 42-274 (288) alignment
Range on Protein: 1281-1521
Range on HMM: 42-274/288.0
DNKAFNRFKNITVYDDNRITLItnpnlDMCQrEYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWrESEIVQ
.| . .|..|.   |  |. |      | ..  ||.|| |   . || .| ||.|.. |.  .|||...  |  |||||   | |.|   .|.  |.. .
anptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf.PsklGe

FEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQ----FQVTNWPTDGIIREPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALE
   .   |   |. .  |..  .. . . |   .  .      . .|. ||.  .  . |.... . .  ||    |.|||.|  | |.|    . ||||
karigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililiale

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
. . .  . . .. .. | ..  |..|  ||  .. ..  .| |.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1281-1429 4.1e-15 50.1 In-house 95-236 (244) alignment
Range on Protein: 1281-1429
Range on HMM: 95-236/244.0
DNKAFNRFKNITVYDDNRITLITNpnlDMcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyQYWRESEIVQ
.|   ||      .| ||. |       |    |||| .|        .|..| |. .|  |||||... .|  .|.|   ||.      .|| .|| ..
nnswknregaglpfdfnrvplskg...sm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdseple

-FEEYFVKCLSSKDCNGYIE-RKFNIFTEKGSSSWDVMQFQVTNWPTDGII
 .||     |. .|    |   ...| ..   |   .  ||..|||.||  
wyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt

Y_phosphatase Protein-tyrosine phosphatase 1282-1514 1.7e-66 219.4 Pfam-A 1-233 (235) alignment
Range on Protein: 1282-1514
Range on HMM: 1-233/235.0
NKAFNRFKNITVYDDNRITLitnpnL---DMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ES
||  ||.|.|..||..|. |         . ..  |||||||.||.||..||..| |...|. |||.|....||..||||.  || |.| | |||   |.
nkkknRykdilpydktrvkl.....kgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

EIVQFEEYFVKCL-SSK-DCNGYIERKFNIFTEKGSS-SWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSI
| .......|..  ..| |...|. ||...  .|..| .  |.|...||||  |. ..|. .|..|..| ... .   ||||||||. |.|.|......|
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
.|||..||. |||.|. |..|...||.|..|.||  .|..|
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 1282-1514 1.7e-66 219.4 In-house 1-233 (235) alignment
Range on Protein: 1282-1514
Range on HMM: 1-233/235.0
NKAFNRFKNITVYDDNRITLitnpnL---DMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ES
||  ||.|.|..||..|. |         . ..  |||||||.||.||..||..| |...|. |||.|....||..||||.  || |.| | |||   |.
nkkknRykdilpydktrvkl.....kgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

EIVQFEEYFVKCL-SSK-DCNGYIERKFNIFTEKGSS-SWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSI
| .......|..  ..| |...|. ||...  .|..| .  |.|...||||  |. ..|. .|..|..| ... .   ||||||||. |.|.|......|
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
.|||..||. |||.|. |..|...||.|..|.||  .|..|
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1282-1521 2.3e-55 182.8 In-house 51-287 (297) alignment
Range on Protein: 1282-1521
Range on HMM: 51-287/297.0
NKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREkrAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQeCCYQYWRESEIVQF
|   .|.|||  || .|..|      |  . .|.|| .|.|...   .|  | ||..|| |||.|..|..||.||||   .|  .  | .|| .. ...|
nfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttf

EEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIR--EPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCK
 .  |. || ....|.|.|....  .|  .   | |.| ..||.. . |  . ...|..|.|| .  ..   ||..|||.  | | ||....   . . |
GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

AEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
 |  ||.|.. | .|...|  | | .||. .|...  .|  .
rekevdifglvkklrqerpylvqtkeqykfvyvavleallse

0041856 (Phosphotyrosine protein) phosphatases II 1282-1520 3.6e-36 119.8 In-house 1-173 (182) alignment
Range on Protein: 1282-1520
Range on HMM: 1-173/182.0
NKAFNRFKNITVYDDNRitlitnpnldmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgqecCYQYWRESEivqf
|.  ||...|  || .|               |||||.. |..  . ||..| |. .|| ||..|. ......||.|.         ...|| | .    
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell....

eeyfvkclsskdcngyierkfniftekgssSWDVMQFQVTNWPTDGIIRePRTVLQVIDEVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckae
                                 ..|.. ..|| .|.   ....|. |.||..      ||||.||||  |.|.|...   . ...    
..............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....

GvVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
| |..... | ||. .||.|.|..||  .. .. ..|.|
g.vsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1282-1511 1.4e-33 111.0 In-house 7-233 (239) alignment
Range on Protein: 1282-1511
Range on HMM: 7-233/239.0
NKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEiVQ
||| ||. ||  || .|. |    |    . .||||.|.. |    .|.| .|  .| .  |||.|. . .   |||| |  |  .. |.||| .|   .
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

FEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKA
. .  |    ..    || | | .     .    | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIY
.  ||.|.  |..|  .|  | | .||  |.
qktvdifnyvkairedrphmvqtseqyvfih

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1282-1511 1.5e-33 111.0 In-house 8-234 (239) alignment
Range on Protein: 1282-1511
Range on HMM: 8-234/239.0
NKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEiVQ
||| ||. ||  || .|. |    |    . .||||.|.. |    .|.| .|  .| .  |||.|. . .   |||| |  |  .. |.||| .|   .
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

FEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKA
. .  |    ..    || | | .     .    | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIY
.  ||.|.  |..|  .|  | | .||  |.
qktvdifnyvkairedrphmvqtseqyvfih

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1282-1519 1.4e-28 94.6 In-house 48-288 (305) alignment
Range on Protein: 1282-1519
Range on HMM: 48-288/305.0
NKAFNRFKNITVYDDNRITLitNPNldmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESEIV
..  ||.|..   |.||. |  ..       ||| ||||    . . || .|.|.|.|  ||| | .. || || |||   | | . |..|.  .. ...
eagknrykdvgcldnnrvkl..egp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

QFEEY----FVKCLSSKDC------NGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVihrqqKIGGGPVVVHCSDTVSRSGVYC
.|||      ||. ||.        .  ...   .    |...  | ..   .||  |.     ..|... .      .   ||.|||||  . |.|   
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvv

SVSIALEQCKAEGVV-DVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
 .   |.|  |  .. |  .. . .|  .  .. | .||  ...||  |..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1282-1518 2.4e-24 80.5 In-house 55-289 (305) alignment
Range on Protein: 1282-1518
Range on HMM: 55-289/305.0
NKAFNRFKNITVYDDNrITLITNPNldMCqrEYINANYVHGY-REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--EI
... ||.... . | . . .. .|.   .  .|| ||||      .. || || |...|. .|| |... ||  ||||| | | |.  | |||  .  | 
aitknryqdvpcqdqs.avkldkps..ps..dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

VQFEE-YFVKCLS-SKDCNGYIERK--FNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIA
...     |. .| ||  .   | .     .|  |. .  | ..| |.||  |.     | |...  .  |  |.   |.|||||  . |.|   ..   
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyi

LEQCKA-EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
||.      .  . .. |..|  .  .. .  ||  |. |.  |.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1282-1520 2.6e-22 73.9 In-house 43-278 (312) alignment
Range on Protein: 1282-1520
Range on HMM: 43-278/312.0
NKAFNRFKNITVYDDNRITLITNPNLdmcqreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE-SEIVQ
 | .||. || ..|  |.||  . |.      || ||.|.       |...|.|.|||.  ||.. .    ..|..|||  ||| | | .|  .   .|.
fkdlnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

FEEYFVK---C----LSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYC---S
.|.. |    |    .  |  .    | ...          . ..| . ||  |.     | |...  | ....|    ||. |||  | |.|  .   |
ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlalies

VSIALEQCKAEGVVDVFQVtksVRRSKPGAVTTLDQYSSIYEVISMYLKL
.  || . . . | |.| .   .|. .  .| .. ||     ..  .|  
miaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvleflys

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1282-1520 4.1e-20 66.8 In-house 47-346 (350) alignment
Range on Protein: 1282-1520
Range on HMM: 47-346/350.0
NKAFNRFKNITVYDDNRITLITNP------NLDMCQREYINANYVHGY----REKRAF--IIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECC
  | ||.|||  |. .|. |  ..      .  .   .||||||..      . .  |  | .|.|. .|| ||.|.|.  ||  |..|    | . | |
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

YQYWRESEIV----QFEEYFVKCLSSKDCNGY---------------------IERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVID---E
|.||.| ..     ....   .  . .|.  |                      . .    |   |  . |.|.|| ||.  ... .|. .||...   .
yrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevknd

VIH------RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCK---------------AEgVVD-VFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
.|         ..  . |..||||  | | |.....   |.. .               |. . | .... . .|. .   | .|||.  ||| .  | .
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisiivnelrkqrismvqnldqfifiYeallfyfa

L
|
L

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1282-1410 9.8e-10 32.4 In-house 34-159 (332) alignment
Range on Protein: 1282-1410
Range on HMM: 34-159/332.0
NKAFNRFKNITVYDDNRITLITNPnldmCQREYINANYVHGYREKRAFIIAQSPMEN-TVRDFWKMIVDYKVSAIVMLCGTEEDG-QECCYQY-WRESEI
|  .||   . ..| .|. |  .      . .. ||..| || .| |.|.||.|... |   ||.|. . | | |...   .|   ... |.   |  | 
nmdmnriphlycfdhsrvelapqd....gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfek

VQFEEYFVKCLSSKDCNGYIERKFniFTEKGS
  . |.  | |   . .  | |||  . ||.|
sflhefgaksleecelkakicrkf..wpekrs

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1283-1516 5.6e-35 115.4 In-house 57-281 (290) alignment
Range on Protein: 1283-1516
Range on HMM: 57-281/290.0
KAFNRFKNITVYDDNRITLItnpnlDMCQREYINANYVHGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SEIVQ
   ||.|...  |  |. |      |  . .|. ||||.|   |  ||..| ....|| |.|.|... ||.||||||   |||.  | ||. |   |.. 
fkknrykdvvcndktrvilk.....dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

FEEYFVKCLSSKDCNGYIE-RKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIALeQCK
| |. | |  ..| .  |  . . .   .   .  .  ...  ||   .     ..|...  .  |.     ||||||||  . |.| . .. ..| |. 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qil

AEG-VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
 .|  .|. .. ...|.|. ..|    ||  . |..  
ldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1284-1519 1.5e-47 157.0 In-house 30-269 (274) alignment
Range on Protein: 1284-1519
Range on HMM: 30-269/274.0
AFNRFKNITVYDDNRITLITNPNlDMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIV---
  ||.|.|   .  |..| .. . .  . .||||||..||.| ..|.. .| |. ||| |||.||   .|. ||||   .|  .. | .|. ..| .   
tknryktilPnensrvllesess.ededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

-QFEEYFVKCLSSKDCNGYIERKFNIFTEKGssSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIALE
 ....  .|  . ...|.|  ||. .   .   . .|. .  |.||     ....|.|....|| . ...     .|||||||  . | |.. ..|||. 
erygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
| ..|.||||....  .|  . | | | .||  |......|||
qlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1284-1522 4e-42 139.0 In-house 40-281 (287) alignment
Range on Protein: 1284-1522
Range on HMM: 40-281/287.0
AFNRFKNITVYDDNRITLITNPNLDMcqrEYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEI-VQFE
  ||. ..  .||.|. | ....|     .||||||| .|... ||| ||.|.  ||||||..... ........    |...  ||.|| | |  ..  
kknryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFVKCLSSKD--CNgYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIRE----PRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE
 | |  |. .    . |  | . .   ..  .  | |... .|| ...        | ||.| . .  ...  . ||.|||..  . |||.. .. . ..
GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHS
. .  | ||| .|   .|  . . | .  |.  .|| .  | |   
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnp

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1284-1516 1.2e-14 48.7 In-house 49-277 (303) alignment
Range on Protein: 1284-1516
Range on HMM: 49-277/303.0
AFNRFKNITVYDDNRITLitnpnldmCQREYINANYVHGYREKRAfIIAQSPMENTVRDFWKMIVDYKVSAIVML-CGTEEDGQECCYQYWRESEIVQFE
  ||| .. . |  .. |        ..  || |.|..   .|.| |..| |.  |  |||.||.. ||  ...|   .| |     . . |. ....||
dknrfvdvicldhskvkl........sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

EYFVKCLSSKDCN---GYIERKFNIFTekGSSSWDVMQFQVTNWPTDGIIRE--PRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQ
| ...    |  .   |.  .   .    |.    .   .  .|| . |  .  |. | |. .     ..   . | |      . |.| ..    |   
ersirvgefkrvelgdgwvlkvlsvsn..gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

CKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
 ..|   .|. .. . ||  .  ||  | |.| .| ... 
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1286-1377 2.2e-12 41.0 In-house 52-157 (349) alignment
Range on Protein: 1286-1377
Range on HMM: 52-157/349.0
NRFKNITVYDDNRITLITNPN-----------LDMC-QREYINANYVHGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQ
||.|.|  |.  |. |   ..            | .   .||||||..      .. .|  | |.  || ||.|.|.  .|  .. |   .| . | |..
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWRESE
||.| .
ywqels

subfamily_eak_pd Subfamily eak 1290-1424 6.1e-09 29.7 In-house 59-190 (332) alignment
Range on Protein: 1290-1424
Range on HMM: 59-190/332.0
NITVYDDNRITLITNpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--EIVQFEEYFVK
.|  || . . | .     . .  ||||  .      | .|..  . |. |  ||.|... |  |||.|    | . |   .|. .   | ..|  . |.
kivpydrylvrltss...qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

CLSSKDCNGYIERKFNIftEKGSSSWDVMQFQVTNWP
. .    | .  |.. .  .||  .  |. ..|  | 
rkefvkrniletrllel..skGnethrvlhykvfGwt

0044763 (Phosphotyrosine protein) phosphatases II 1298-1520 2.5e-23 78.1 In-house 6-173 (178) alignment
Range on Protein: 1298-1520
Range on HMM: 6-173/178.0
RITLITNpnLDMCQREYINANYVHGYrekraFIIAQSPMentvRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIvqfeeyfvkclsskdcngy
|  |..    ...  .||||... ..     ..... |.     |..... ......||.|... | |.. |..|| |..                    
rvllsnl..eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

ierkfniftekgssswdvmqFQVTNWPTDGIIREP-RTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRS
                    .|. ..|...    . .  .. . | |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrer

KPgAVTTLDQYSSIYEVISMYLKL
.| .|.. .|.  .||. ...|| 
Rp.ivpnpgqlrqLyefelrllke

subfamily_CG42327_pd Subfamily CG42327 1299-1441 4e-15 50.3 In-house 45-189 (319) alignment
Range on Protein: 1299-1441
Range on HMM: 45-189/319.0
ITLITNPNLDmcQREYINANYVHGYREKRA-FIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQ----FEEYFVKCLSSKD
..|   .. |  . ||..|.|| ||.. .. .| || ..|..  |||... . .   || |.   | | . | .|.  .|  .    . .. |     . 
vvlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev

CNGYIERKFNIFTEKGSSSWDVMQFQVtNWPTDGIIREPRTVLQVIDE
 . |.   . .   ... | ..  .   .|.  ..  |..... .. |
kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1308-1507 1.8e-24 81.0 In-house 71-270 (301) alignment
Range on Protein: 1308-1507
Range on HMM: 71-270/301.0
DMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESEIVQFEEYFVKCLSSKDC--NGYIERKFN
.  .|  | ||..    . . ||..|.|..||  ||| |.| |.|  ||||. . |. .| | .|   . || .. . . .|  ...    .  ..|...
vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtle

IFTEKG-SSSWDVMQFQVTNWPTDGIIREPRTVLQVIdEVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
.    |  ..  |. .| ..|.  |. .    . ... |.. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| 
vedstgkfatrtvthyqysewtdrgvPkshaelfdlm.elvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

TLDQY
|  | 
tnsql

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1311-1519 2.8e-25 84.0 In-house 45-260 (290) alignment
Range on Protein: 1311-1519
Range on HMM: 45-260/290.0
QREYINANYVHgYREKRAFIIAQSPMEN-------TVRDFWKMIVDYKVSAIVMLCGTEEDGQE----CCYQYWRES--EIVQFEEYFVKCLSSKDCNGY
. .|| ||.|  . .  ..|. ||| |.       |. .|| |. . ||  .||||  ||  ..     | .| .||  |...|.   ||| |    .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKFNIFTEKGsSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKSVRRS
..|.  .  ...   . |   .. .| .  . ....|.|..|. |  ..      ||.||| | .||| .  .. ..       .| | . .| |..|. 
etRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

KPGAVTTLDQYSSIYEVISMYLK
.  |.|.  ... .  .| ....
ralaitsalelafvdagivllai

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1311-1428 2.5e-15 50.9 In-house 12-126 (130) alignment
Range on Protein: 1311-1428
Range on HMM: 12-126/130.0
QREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyQYWRESEIVQ-FEEYFVKCLSSKDCNGYIERK-FNIFTEK
. .||||..|      . .. .| |. .|  |||||...  |  .|.|   ||.      .|| .|| .. .||  .  |. .|   .|. . ..|  . 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnleiesdl

GSSSWDVMQFQVTNWPTDGI
  |   .  ||..|||.|| 
neshqaltmfqisnwpsdgt

0043147 (Phosphotyrosine protein) phosphatases II 1312-1513 3.8e-30 100.3 In-house 5-156 (172) alignment
Range on Protein: 1312-1513
Range on HMM: 5-156/172.0
REYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTeedgqeccyqywreseivqfeeyfvkclsskdcngyierkfniFTEKGSS
. ||||.|...|.  . ||. | |. ||. |||.|. ......||.|..                                            .. .   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpell

SWDVMQFQVTNWPTDGIIrEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSVRRSKPGAVTTLDQYSSIY
.  ..|.. ..||  |    .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . ||. .||||.. .||  .|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfly

EV
. 
yf

0051429 (Phosphotyrosine protein) phosphatases II 1313-1519 1.5e-38 128.3 In-house 5-226 (272) alignment
Range on Protein: 1313-1519
Range on HMM: 5-226/272.0
EYINANYVHGYRE---KRAFIIAQSPMENTVRDFWKMiVDYKVSAIVMLCGTEEDGQECCYQYWR------------ESEIVQFEEYFVKCLSSKDCNGY
 ||||..| ||     ..... .. |...|..|||..  ......||.|...|| |.. |..||             . . . .  ..|..|| . .. |
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

IERKFNIFTE-KGSSSWDVMQFQVTNWPTDGIIREPrtVLQVIDEVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQ
| |.. .  . . . .  ||... |.||..|. .|.  .|...... .      ||||.||||  ..|.|... . . |..  .| .||        ...
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

VTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
. . .|.  |||| | .||  .||..  .|.
aveelraqrpgavqteeqylflyeallellr

0036282 (Phosphotyrosine protein) phosphatases II 1313-1512 7.9e-34 112.2 In-house 3-164 (174) alignment
Range on Protein: 1313-1512
Range on HMM: 3-164/174.0
EYINANYVHGYREKRAFIIAQSPMEntvrdFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWREseivqfeeyfvkclsskdcngyierkfniftEKGSSS
 ||||.......  . .|. | |..     ||.|. .......|||.  .|.| . |..|| |                                . . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

WDVMQFQVTNWPTDGIIREPRtVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
  ..|.. ..|| .|    .  .|.....| . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy





0046846 (Phosphotyrosine protein) phosphatases II 1313-1518 9e-30 99.1 In-house 13-173 (176) alignment
Range on Protein: 1313-1518
Range on HMM: 13-173/176.0
EYINANYVHGYRekraFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFeeyfvkclsskdcngyierkfniftekgsss
 |||||.. |.|    .|. | |...|. ||..|. .....|.|.|.   | |.  |..|| | | ...                               
dyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

wdvmQFQVTNWPTDGIIREpRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLDQYSSIY
    |.....||  |.    . .|......  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| .||  .|
....qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfly

EVISMYL
|.. ..|
efellll

0051082 (Phosphotyrosine protein) phosphatases II 1313-1513 8.7e-26 85.7 In-house 4-148 (151) alignment
Range on Protein: 1313-1513
Range on HMM: 4-148/151.0
EYINANYVHGYrekraFIIAQSPMEntvrDFWKMIVDYKVSAIVMLCGTEEDGqeCCYQYWRESEivqfeeyfvkclsskdcngyierkfniftekgsss
 |||..|| |.     ... . |..    ||.... ......||.|...|| |   |..|..| .                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

WDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
 .|.......||. |.   . .||........     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. 
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

V
.
a

0049260 (Phosphotyrosine protein) phosphatases II 1319-1512 4.9e-28 93.1 In-house 1-144 (152) alignment
Range on Protein: 1319-1512
Range on HMM: 1-144/152.0
YVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWreseivqfeeyfvkclsskdcngyierkfniftekgssswdvmQF
...||. ...||..| |..||. |||.|. ......||||.  .|.| ..|.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QVTNWPTDGIIREPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaeGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
. ..|| .|    .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .||
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1321-1515 2.9e-28 93.4 In-house 230-435 (440) alignment
Range on Protein: 1321-1515
Range on HMM: 230-435/440.0
HGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEdgqECCYQYWR-ESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKgsSSWDVMQFQ
.||  | ||| .| |.. || |||... ||..|.|.||   ..     |  ||  ..  | |  . |    |.. |    | ...   .     .. ||.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfe

VTNWPT----DGIIREPR---TVLQVIDEV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|  |||    ||.  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | ||
vqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl

DQYSSIYEVIS
 .|   | ...
tdyllcykllt

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1325-1513 6.8e-17 56.3 In-house 3-199 (199) alignment
Range on Protein: 1325-1513
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCY-QYWR--ESEIVQFEEYFV--KCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQ
 .| .| .| |. .|. |||.|. .     |||.   . . .|. |  ||   ||   ..    |  |....|         .   |    |. .. ..|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VTNWPTDGIIREPRTVLQVI--DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEV
 | |           |  |.   || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1326-1513 8.2e-17 56.0 In-house 3-198 (198) alignment
Range on Protein: 1326-1513
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCY-QYWR--ESEIVQFEEYFV--KCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQV
.| .| .| |. .|. |||.|. .     |||.   . . .|. |  ||   ||   ..    |  |....|         .   |    |. .. ..| 
qrryiatqhplretladfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPTDGIIREPRTVLQVI--DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEV
| |           |  |.   || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1331-1503 7.3e-11 36.6 In-house 39-206 (255) alignment
Range on Protein: 1331-1503
Range on HMM: 39-206/255.0
IaqspmenTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSskDCNGYIERKFNIFTEKG--SSSWDVMQFQVTNWPTD
.       ||  |...||  | . .||||  .|.|.| | .|.     |  ....  | .      .  . |  .| .. |      .|  .. . |.  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GIIREPRTVLQVIDEVihRQQKigggPVVVHCSDTVSRSGVYCSVSIALE-------QCKaEGVVDVFQVTKSVRRSKPGAVTT
   ...| .|...  |  |. |    .||||||  . ||  .  . ..         . .  . .|  .. . .| ....|. |
naPelareilnilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldtte.tveldylslleelrskrkraiht

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1332-1508 9.1e-16 52.2 In-house 96-278 (302) alignment
Range on Protein: 1332-1508
Range on HMM: 96-278/302.0
AQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSSK-DCNGYIERK-FNIFTEK-------GSSSWDVMQFQV
   |  .|.  .| .| .|.|. .| ||.  ||... | .|. .   . ..| .| || .| | | . . ..| |...| .             |  .. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWPTDGIIREPRTVLQVIDEVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
. ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| . .|  
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

subfamily_hpo-7_pd Subfamily hpo-7 1336-1505 5.1e-10 33.7 In-house 43-214 (263) alignment
Range on Protein: 1336-1505
Range on HMM: 43-214/263.0
MENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESEIVQFEEYFVKCLSSKDcnGYIERKFNIFT--EKGSSSWDVMQFQVTNWPTDGIIRE
. .|.  |...||  | . .||||  .|.|.| | .|.     |  ....  | .  ...    . .  ..    ..     .| ... . |.     ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PRTVLQVIDevIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALE------QCKAEGVVDVFQVTKSVRRSKPGAVTTLD
.| .|....  . |. |    ..|||||  . ||  .  . ..        .    . .|  .. . .| |...|. |  
areilnilk..varnsk....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPm

0048179 (Phosphotyrosine protein) phosphatases II 1347-1512 6.1e-13 44.2 In-house 25-139 (144) alignment
Range on Protein: 1347-1512
Range on HMM: 25-139/144.0
IVDYKVSAIVMLCGTEEDGQECCYqywreseivqfeeyfvkclsskdcngyierkfniftekgssswdVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQ
. ........ |. . |   . ..                                            ..|.. ..||  |.   .  .|.... . . .
lkklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllellleflefieeal

QkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
.   ||||.||||  |.|.|...   . .     .| ...... . ||.  ||||.. .|.  ..|
e..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 1398-1517 2.6e-14 48.6 In-house 30-142 (145) alignment
Range on Protein: 1398-1517
Range on HMM: 30-142/145.0
IERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKSVRRSK
| . .|. .|.   .  ..|.. ..||  |.   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqr

PGAVTTLDQYSSIYEVISMY
||||.. .|.  .||.. ..
pgavpnpgqlrflyefelel

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1409-1517 1.7e-06 21.6 In-house 214-343 (349) alignment
Range on Protein: 1409-1517
Range on HMM: 214-343/349.0
GSSSWDVMQFQVTNWPTDGIIREPRTVLQV-------IDEVIHR--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALE--QCKAEGVV----------DVF
 .. . ..|.|| ||.  ... .| ..||        ||.   |   ..    ...||||    |.||.. . . |.  .   .  .           ..
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

QVTKSVRRSKPGAVTTLDQYSSIYEVISMY
 .  ..|. .   |  | |.  ||| .  |
iivnelrkqrismvqnlaqfiaiyealLky

PTPc_DSPc_SM00012 1415-1514 1.5e-24 81.6 In-house 2-103 (105) alignment
Range on Protein: 1415-1514
Range on HMM: 2-103/105.0
VMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
|.....|.||  |. .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|..||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1419-1516 2.6e-06 21.2 In-house 196-288 (310) alignment
Range on Protein: 1419-1516
Range on HMM: 196-288/310.0
QVTNWPTDGIIREP-RTVLQVIdeviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
.  |||  |.  |   || | .      |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . |  ||  |  |  .
kwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii

subfamily_CG42327_pd Subfamily CG42327 1451-1519 7.7e-14 46.1 In-house 247-316 (319) alignment
Range on Protein: 1451-1519
Range on HMM: 247-316/319.0
GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
 ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | .||  || |.|.| |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1453-1514 2.8e-07 24.7 In-house 230-291 (297) alignment
Range on Protein: 1453-1514
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||.|.  .|...
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1455-1520 3.9e-07 24.4 In-house 2-67 (69) alignment
Range on Protein: 1455-1520
Range on HMM: 2-67/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.. .   |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1455-1520 7.6e-07 23.4 In-house 1-66 (69) alignment
Range on Protein: 1455-1520
Range on HMM: 1-66/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.. .   |||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl