Gene PTPRD-76 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP135_AA protein Get Run
AqueP135_AA_2914-3191 phosphatase_domain Get Run
AqueP135_AA_3204-3484 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ig_3 Immunoglobulin domain 136-223 3.1e-10 32.1 Pfam-A 12-73 (75) alignment 
Range on Protein: 136-223
Range on HMM: 12-73/75.0
IL---AtigdanLTLTCNATGFP-APNITWVrlpsndlnesmildlydsdapetiDDDSMISFSTDSDTDSSSILTFDSIEYNDFGHYACIA
.           .||||.|.|.| .|.|.|                         .. .... ....  .|.|.||. |  ..| | | |.|
vtsggn......vtLtCsaeggpppptisWy........................ietppelqgsegssssestLtissvtsedsGtYtCva
I-set Immunoglobulin I-set domain 138-226 8.9e-08 23.8 Pfam-A 12-78 (90) alignment 
Range on Protein: 138-226
Range on HMM: 12-78/90.0
ATIGDaNLTLTCNATGFPAPNITWVRLpSNDLNEsmildlydsdapetiddDSMISFSTDSdtdSSSILTFDSIEYNDFGHYACIAMQS
...|. ...|.|...| | |...|..   ..|..                 .. .... ..   ... ||....| .| | | | |  |
vseGe.svelectveGepepsvsWakd.gselks.................sqrvkvtvee...aeytLtIsnvevsDeGkYtckatns
V-set Immunoglobulin V-set domain 142-233 9.1e-06 16.5 Pfam-A 16-108 (114) alignment 
Range on Protein: 142-233
Range on HMM: 16-108/114.0
DANLTLTCNATgfP---APNITWVRLPSNDLNESMIldlydSDAPETIDDDSMISFSTDSDT-----DSSSILTFDSIEYNDFGHYACIAMQSNDSLMGE
....||.|  .  .     .|.|.. ...  .| .|      . .|| ..  . ||| .        .|.  ||. ... .| | | | ...||   .|.
GgsvtLpCfys..ssensqsiyWykqktgskpelii.....ryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsdsnedvfga
Ig_2 Immunoglobulin domain 143-230 5.1e-07 21.6 Pfam-A 15-69 (80) alignment 
Range on Protein: 143-230
Range on HMM: 15-69/80.0
ANLTLTCNATGFPAPNITWVRlPSNDLNESmildlydsdapetidddsmisfsT-DsdtdsssiL-TfDSIEYNDFGHYACIAmqSNDSL
 |.|||| |.|.|.|...| .  .. |..|                       .          | .  .....| |.| | |  ||...
envtLtCqapgnptpkvqwyk.dgeelsqs.......................qna........lfi.pnvsaedsGtYtCra..snseg
I-set Immunoglobulin I-set domain 255-352 1.1e-11 36.3 Pfam-A 3-90 (90) alignment 
Range on Protein: 255-352
Range on HMM: 3-90/90.0
VITPSNPLIVSRNENASFNCTAQGGPNNTIVWIKGenNSSLSFrpppinvlRTLELFTVIESGPILTFTSVNGSNGGIYTCVVLNEAGIESDAVELRV
. ...... || .|.....||..| |. .. | |.  .|.|.              .|| |.   ||...|. |. |.|||.. |.|| ..  .|| |
ftqklkdvevseGesvelectveGepepsvsWakd..gselks........sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
Ig_2 Immunoglobulin domain 255-352 5.1e-09 28.0 Pfam-A 3-80 (80) alignment 
Range on Protein: 255-352
Range on HMM: 3-80/80.0
VITPSNpLIVSRNENASFNCTAQGGPNNTIVWIKGENNSSlsfrpP---PinvlrtlelftviesgpiL-TfTSVNGSNGGIYTCVVLN-EAGIESDAVE
|.....   |. .||  ..|.|.| |. .. | |...  |     .                      | .  .|. ...|.|||.. | | .. |. ||
vlsapp.tvvtegenvtLtCqapgnptpkvqwykdgeels.....qsqna..................lfi.pnvsaedsGtYtCrasnsegskqsnsve

LRV
..|
vtv
Ig_3 Immunoglobulin domain 255-339 1.2e-07 23.9 Pfam-A 4-75 (75) alignment 
Range on Protein: 255-339
Range on HMM: 4-75/75.0
VITPSNPLIVSRNEnASFNCTAQGGP-NNTIVWIkgennsslsfrppPINVLRTLELFTVIESGPILTFTSVNGSNGGIYTCVVLN
......| ..|  .  ...|.|.||| . || |              . .           .|. .||..||. .. | ||||. |
isvspsptvtsggn.vtLtCsaeggpppptisWy.............ietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_3 Immunoglobulin domain 353-427 6.2e-10 31.2 Pfam-A 1-74 (75) alignment 
Range on Protein: 353-427
Range on HMM: 1-74/75.0
RPEILTNPSNIYTQDGEgdVSFECLADSFP-SPQYRWERFNETLNEFYPISNESERFLMFNEVEYEDNGRYRCVAT
.|.| ..||.. | .|.  |.. | |...| .|...| . ..  ..   .|..||  | . .| .||.| |.|||.
kPvisvspsptvtsggn..vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas
I-set Immunoglobulin I-set domain 354-429 3.9e-09 28.2 Pfam-A 1-78 (90) alignment 
Range on Protein: 354-429
Range on HMM: 1-78/90.0
PEILTNPSNIYTQDGEgDVSFECLADSFPSPQYRWERFNETLNE--FYPISNES-ERFLMFNEVEYEDNGRYRCVATAP
|.. . .... .. || .|..|| .   | |. .| . .. |..   . ...|. |  |....|| .|.|.|.|.||  
pkftqklkdvevseGe.svelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns
Ig_2 Immunoglobulin domain 369-430 2.1e-09 29.3 Pfam-A 14-68 (80) alignment 
Range on Protein: 369-430
Range on HMM: 14-68/80.0
EGDVSFECLADSFPSPQYRWERFNETLNefypisnESER--FLmfNEVEYEDNGRYRCVATAPT
  .| . | |...| |.. |.. .|.|.       .|..  |.  ..|..||.|.|.|.|. . 
genvtLtCqapgnptpkvqwykdgeels.......qsqnalfi..pnvsaedsGtYtCrasnse
Ig_2 Immunoglobulin domain 452-548 2.6e-06 19.3 Pfam-A 4-69 (80) alignment 
Range on Protein: 452-548
Range on HMM: 4-69/80.0
IDPAFTIATNGSTVTFTCSARGGPNNTFVWTRSnatgsmanetelmslaamipidvdgfldlaGpLIIENGTE-LTLEYINATmDGSNYSCVVINEAG
... .| .| |..||.||.|.| |. .. |..                               |  ....... | .  ..|. |. .|.|.. |. |
lsapptvvtegenvtLtCqapgnptpkvqwykd..............................g.eelsqsqnalfipnvsae.dsGtYtCrasnseg
Ig_3 Immunoglobulin domain 455-543 5.3e-06 18.6 Pfam-A 17-73 (75) alignment 
Range on Protein: 455-543
Range on HMM: 17-73/75.0
AftiatngstVTFTCSARGGP-NNTFVWTrsnatgsmanetelmslaamipIDVDGFLDLAGPlIIENGTELTLEYINATMDGSnYSCVV
          ||.||||.||| . |. |.                      |. .. |.  .    .... ||..  ..  .|. |.||.
n.........vtLtCsaeggpppptisWy......................ietppelqgseg.ssssestLtissvtsedsGt.YtCva
I-set Immunoglobulin I-set domain 458-558 6.9e-06 17.8 Pfam-A 11-90 (90) alignment 
Range on Protein: 458-558
Range on HMM: 11-90/90.0
IATNGSTVTFTCSARGGPNNTFVWTRSnatGSMANEtelmslAAMIPIDVDGfldlagpliieNGTELTLEYINATmDGSNYSCVVINEAGFVAVETTLY
 .. |..|...|...| |. .. |..    ||  ..         . ..|..           . ..||.. ...  |  .|.|.. |.|| .  ...| 
evseGesvelectveGepepsvsWakd...gselks......sqrvkvtvee...........aeytLtIsnvevs.DeGkYtckatnsagkaeakaeLk

V
|
V
Ig_3 Immunoglobulin domain 559-633 8.2e-11 34.0 Pfam-A 1-75 (75) alignment 
Range on Protein: 559-633
Range on HMM: 1-75/75.0
APIITLHPQDRLVTQGEyFTLSCLADAFP-SPTYQWERMNRTSGNFEEISGEISSDLRFNNVDFDEFGMYRCVASS
.|.|...|.   .. |.  ||.| |. .| .||..| . .  . .  |.|....|.| . .|...  | |.||||.
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 559-636 3.4e-09 28.6 Pfam-A 1-69 (80) alignment 
Range on Protein: 559-636
Range on HMM: 1-69/80.0
APIITLHPQDrlVTQGEYFTLSCLADAFPSPTYQWERMNRTSGNFEEIsgeissdLRFNNVDFDEFGMYRCVASSEGI
.|...  |.   ||.|| .|| | |...| |..||.. . .  . ...       |  .||  .. | |.|.|| .. 
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnseg
I-set Immunoglobulin I-set domain 562-636 4e-06 18.5 Pfam-A 3-80 (90) alignment 
Range on Protein: 562-636
Range on HMM: 3-80/90.0
ITLHPQDRLVTQGEYFTLSCLADAFPSPTYQWERMNRTSGNFEEISGEIS---SDLRFNNVDFDEFGMYRCVASSEGI
.| ...|  |..||  .|.| .   | |. .| . ..   . .... . .   . |...||. .. | |.|.|. .  
ftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsag
I-set Immunoglobulin I-set domain 659-754 6.4e-11 33.9 Pfam-A 7-89 (90) alignment 
Range on Protein: 659-754
Range on HMM: 7-89/90.0
PDTQIVSRNSSPTFTCEASGGPNTTLAWIRGnEDNIEStqtpididsffdFLDVIVSETAPSLELSLENVNGTDGGNYTCIAVNEAGYDNGTVSLL
.. . || ..| ...|...| |. .  | .. . ...|              .| |...  . .| ..||.  | |.||| | |.|| .. ...| 
lkdvevseGesvelectveGepepsvsWakd.gselks............sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLk
Ig_2 Immunoglobulin domain 659-745 2.1e-09 29.3 Pfam-A 7-69 (80) alignment 
Range on Protein: 659-745
Range on HMM: 7-69/80.0
PDtQIVSRNSSPTFTCEASGGPNTTLAWIRGNeDNIESTQTPididsffdfldvivsetapsleLSLENVNGTDGGNYTCIAVNEAG
|. . |. ... |.||.|.| |.... | ... . ....|                        | . ||. .|.|.||| | |. |
pp.tvvtegenvtLtCqapgnptpkvqwykdg.eelsqsqna......................lfipnvsaedsGtYtCrasnseg
Ig_3 Immunoglobulin domain 666-742 2.7e-08 25.9 Pfam-A 15-75 (75) alignment 
Range on Protein: 666-742
Range on HMM: 15-75/75.0
RNSsPTFTCEASGGP-NTTLAWIrgnedniestqtpidiDSFFDFLDVIVSETAPSLELSLENVNGTDGGNYTCIAVN
  .  |.||.| ||| ..|. |                 ..  . |.   .    .  |....|.  | |.|||.| |
ggn.vtLtCsaeggpppptisWy................ietppelqgsegssssestLtissvtsedsGtYtCvasN
ig Immunoglobulin domain 668-739 7.1e-07 20.5 Pfam-A 2-63 (64) alignment 
Range on Protein: 668-739
Range on HMM: 2-63/64.0
SSPTFTCEA-SGGPNTTLAWIRGNEDNIESTQTPIDID-----SffdfldvivsetapslELSLENVNGTDGGNYTCI
|| |.||.. ||.|.|.  |....  ..||..|  . .     .                 | . ||   |.|.||| 
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe................vLtinnvtkedsGtYtCv
Ig_3 Immunoglobulin domain 757-829 1.3e-10 33.4 Pfam-A 2-74 (75) alignment 
Range on Protein: 757-829
Range on HMM: 2-74/75.0
PEILTNPEEQYAEVGDdVTLNCSADSFP-APNYQWEmmNRTSGYFEPLDDETSYVLTLE--SISYEEYGMYRCVAT
|.| ..|..   ..|  |||.|||...| .|...|   . |...... ..  |.  ||   | ..| .| |.|||.
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy..ietppelqgsegssssestLtissvtsedsGtYtCvas
I-set Immunoglobulin I-set domain 757-835 2.7e-08 25.5 Pfam-A 1-81 (90) alignment 
Range on Protein: 757-835
Range on HMM: 1-81/90.0
PEILTNPEEQYAEVGDDVTLNCSADSFPAPNYQWEMMNR---TSGYFEPLDDETSYVLTLESISYEEYGMYRCVATADgIEE
|.. . .... ...|..|.|.|..   | |. .|   ..   .|  ..   .| .| ||..... .. | |.|.||   ...
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns.agk
Ig_2 Immunoglobulin domain 762-846 3.9e-13 41.2 Pfam-A 5-80 (80) alignment 
Range on Protein: 762-846
Range on HMM: 5-80/80.0
NPEEQYAEVGDDVTLNCSADSFPAPNYQWEMMNrtsgyfEPLDDETS--YVltlESISYEEYGMYRCVATADGIeeNATSTPALVTV
... .... |..|||.|.|...|.|..||.  .      |.|.  ..  ..    ..|.|. | |.|.|. ..    ..|..  |||
sapptvvtegenvtLtCqapgnptpkvqwykdg......eelsqsqnalfi...pnvsaedsGtYtCrasnseg..skqsnsvevtv
I-set Immunoglobulin I-set domain 853-948 2.1e-07 22.6 Pfam-A 4-90 (90) alignment 
Range on Protein: 853-948
Range on HMM: 4-90/90.0
DATPMNRTVSINDTANFTCRAQGGPGNMFRWVKGiftGPTFNApldvdeflD-----DLDNisLSYflSFTVSG-GAADGGYYTCIVVNEAGYDTDNVTL
. .. . .||........|...| |   ..|.|.   |   .         .     . ..   .|  ..|.|   ..| | ||| . |.|| .. ...|
tqklkdvevseGesvelectveGepepsvsWakd...gselks........sqrvkvtvee..aey..tLtIsnvevsDeGkYtckatnsagkaeakaeL

YV
 |
kV
Ig_2 Immunoglobulin domain 859-946 4.3e-06 18.7 Pfam-A 9-78 (80) alignment 
Range on Protein: 859-946
Range on HMM: 9-78/80.0
RTVSINDTANFTCRAQGGPGNMFRWVKGiftgptfnapldvDEFLDDLDNIslsyflSFT--VSggAADGGYYTCIVVN-EAGYDTDNVTL
 .|. ... ..||.|.| |   . | |.             .|.|.   |.      .|.  ||  | |.| ||| . | | .  .. |..
tvvtegenvtLtCqapgnptpkvqwykd.............geelsqsqna......lfipnvs..aedsGtYtCrasnsegskqsnsvev
Ig_2 Immunoglobulin domain 950-1026 3.9e-09 28.4 Pfam-A 2-69 (80) alignment 
Range on Protein: 950-1026
Range on HMM: 2-69/80.0
PVITLNPtdQYAHPGDTVTISCMADSYPPPTYQWQVLNTDTNMYQDIngemmtSYTiEDIDYDQFGMYRCAVTTPTI
||.. .|  .... |..||. | |.. |.|..||.  .. ..  |..      ...   . ... | |.| .. .  
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna......lfi.pnvsaedsGtYtCrasnseg
Ig_3 Immunoglobulin domain 950-1020 3.3e-08 25.6 Pfam-A 2-72 (75) alignment 
Range on Protein: 950-1020
Range on HMM: 2-72/75.0
PVITLNPTDQYAHPGDtVTISCMADSYP-PPTYQWQVLNTDTNMYQDINGEMMTSYTIEDIDYDQFGMYRCA
|||...|       |  ||..| |...| |||..|.  ... .  ...... ....||.. .... | |.| 
Pvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCv
I-set Immunoglobulin I-set domain 950-1024 2.7e-07 22.3 Pfam-A 1-78 (90) alignment 
Range on Protein: 950-1024
Range on HMM: 1-78/90.0
PVITLNPTDQYAHPGDTVTISCMADSYPPPTYQWQVLNTDTNMYQDINGEMMT---SYTIEDIDYDQFGMYRCAVTTP
|..|  ..|. .. |..|...| .   |.|. .|.  .....  |... ..     . ||.... .. | |.| .|  
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns
Ig_3 Immunoglobulin domain 1037-1142 1.8e-06 20.1 Pfam-A 4-75 (75) alignment 
Range on Protein: 1037-1142
Range on HMM: 4-75/75.0
ITVSSNSSVTIDPDfviaengsnVTFNCLSRGGP-NNRFIWLrpsaldslisnnpsvssllnsespiKVDDIVNQLSNITLSNEPTFTLYSINaTEDGGN
|.||....|| ..          ||..| ..||| . .. |.                         .  . ..| |... |.| |.|. | .  || |.
isvspsptvtsggn.........vtLtCsaeggpppptisWy.........................ietppelqgsegssssestLtissvt.sedsGt

YACYVVN
| |.. |
YtCvasN
I-set Immunoglobulin I-set domain 1045-1155 8.1e-07 20.7 Pfam-A 3-90 (90) alignment 
Range on Protein: 1045-1155
Range on HMM: 3-90/90.0
VTIDPDFVIAENGSNVTFNCLSRGGPNNRFIWLRPsalDSLISNnpsvssllnsespikvddivNQLSN----ItlsNEPTFTLYSINAtEDGGNYACYV
.|. .. | .. |..|...|  .| |. .. |..    .| ...                    .|  .        .| |.|...... .| |.| | .
ftqklkdvevseGesvelectveGepepsvsWakd...gselks....................sqrvkvtvee...aeytLtIsnvev.sDeGkYtcka

VNPAGVESNTTTLYV
 | || .. ...| |
tnsagkaeakaeLkV
Ig_2 Immunoglobulin domain 1047-1153 5.9e-09 27.8 Pfam-A 4-78 (80) alignment 
Range on Protein: 1047-1153
Range on HMM: 4-78/80.0
IDPDFVIAENGSNVTFNCLSRGGPNNRFIWLRPsaldslisnnpsvssllnsespikvDDIVNQLSNItlsnepTFTlYSINAtEDGGNYACYVVN-PAG
... .. .. |.|||..| ..| |. ...| .                          .....|  |.       |.  ...| ||.|.| |.. | . .
lsapptvvtegenvtLtCqapgnptpkvqwykd.........................geelsqsqna......lfi.pnvsa.edsGtYtCrasnsegs

VESNTTTL
  ||....
kqsnsvev
Ig_3 Immunoglobulin domain 1157-1229 4.7e-11 34.7 Pfam-A 2-74 (75) alignment 
Range on Protein: 1157-1229
Range on HMM: 2-74/75.0
PVITEDPREAFTNVSDtVTLTCRADSFP-APNYQWEmmNRTN--GYFEPLTGQTSYVLTLESISYEEYGMYRCVAT
|||.  |..  |..   |||||.|...| .|...|   . |.        ..... .||..| ..| .| |.|||.
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy..ietppelqgsegssssestLtissvtsedsGtYtCvas
I-set Immunoglobulin I-set domain 1157-1235 1.3e-06 20.1 Pfam-A 1-81 (90) alignment 
Range on Protein: 1157-1235
Range on HMM: 1-81/90.0
PVITEDPREAFTNVSDTVTLTCRADSFPAPNYQWEMMNRT---NGYFEPLTGQTSYVLTLESISYEEYGMYRCVATADgIEE
|..|. .... ... ..|.|.|..   | |. .|   ..    .  ..    . .| ||..... .. | |.|.||   ...
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns.agk
Ig_2 Immunoglobulin domain 1158-1246 1.3e-11 36.4 Pfam-A 3-80 (80) alignment 
Range on Protein: 1158-1246
Range on HMM: 3-80/80.0
VITEDPREafTNVSDTVTLTCRADSFPAPNYQWEMMNrtngyfEPLTGQTS--YVltlESISYEEYGMYRCVATADGIeeNATSTPALVTV
|... | .   . ...|||||.|...|.|..||.  .      |.|. ...  ..    ..|.|. | |.|.|. ..    ..|..  |||
vlsapptv..vtegenvtLtCqapgnptpkvqwykdg......eelsqsqnalfi...pnvsaedsGtYtCrasnseg..skqsnsvevtv
ig Immunoglobulin domain 1172-1228 4.5e-06 17.9 Pfam-A 2-64 (64) alignment 
Range on Protein: 1172-1228
Range on HMM: 2-64/64.0
DTVTLTCRA-DSFPAPNYQWEMMNRTNGYFEPLTG-QTSY----VLTLESISYEEYGMYRCVA
..|||||.. .  | ....|   . ..  ...  . ....    |||. . ..|  | |.||.
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
I-set Immunoglobulin I-set domain 1256-1348 5.3e-08 24.6 Pfam-A 7-90 (90) alignment 
Range on Protein: 1256-1348
Range on HMM: 7-90/90.0
PMYSTVSINDTANFTCRAQGGPGNMFRWIKGnfnGPTLTAplnvsqfFNSLSIFRSGYELSFIVS-GGAADGGYYTCIVVNEAGYATDNVMLFV
.   .||........|...| |   ..| |.   |  |.         .....  .. | ....|   ..| | ||| . |.|| |. .. | |
lkdvevseGesvelectveGepepsvsWakd...gselks.......sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
Ig_2 Immunoglobulin domain 1256-1342 2.5e-06 19.4 Pfam-A 8-74 (80) alignment 
Range on Protein: 1256-1342
Range on HMM: 8-74/80.0
PmySTVSINDTANFTCRAQGGPGNMFRWIKGNfngptltAPLNVSQ-FfnslsifrsgyelSFIVSGGAADGGYYTCIVVNE-AGYATD
|  ..|. ... ..||.|.| |   . | |..       ..|. ||               .|| .  | |.| ||| . |.  .  ..
p..tvvtegenvtLtCqapgnptpkvqwykdg.......eelsqsqna.............lfipnvsaedsGtYtCrasnsegskqsn
Ig_3 Immunoglobulin domain 1349-1420 5.4e-09 28.2 Pfam-A 1-72 (75) alignment 
Range on Protein: 1349-1420
Range on HMM: 1-72/75.0
PPVITLNPTDQYAHPGDtVTISCMADSFP-PPTYQWQVLNTDTNMYQDINGETMTNFTIEEIDYDQFGMYRCA
.|||...|       |  ||..| |...| |||..|.  ... .  ......... .||.. .... | |.| 
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCv
Ig_2 Immunoglobulin domain 1350-1426 1.1e-09 30.2 Pfam-A 2-69 (80) alignment 
Range on Protein: 1350-1426
Range on HMM: 2-69/80.0
PVITLNPtdQYAHPGDTVTISCMADSFPPPTYQWQVLNTDTNMYQDIngetmtnFTIEEIDYDQFGMYRCAVTTPTI
||.. .|  .... |..||. | |...|.|..||.  .. ..  |..       . | .. ... | |.| .. .  
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnseg
I-set Immunoglobulin I-set domain 1350-1424 3.9e-08 25.0 Pfam-A 1-78 (90) alignment 
Range on Protein: 1350-1424
Range on HMM: 1-78/90.0
PVITLNPTDQYAHPGDTVTISCMADSFPPPTYQWQVLNTDTNMYQDINGETMT---NFTIEEIDYDQFGMYRCAVTTP
|..|  ..|. .. |..|...| .   |.|. .|.  .....  |... .       .||.... .. | |.| .|  
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns
Ig_3 Immunoglobulin domain 1440-1541 1e-06 20.9 Pfam-A 7-75 (75) alignment 
Range on Protein: 1440-1541
Range on HMM: 7-75/75.0
SPNSSVSIDPDlhiadngsdITFTCSANGGP-NNTFLWVrsdefenlislssvlqNLPFQNTISVQDIVDELSTITLETGTtfsiyninaTEDGGEYLCI
||...|. ..          .|.|||| ||| . |. |                 . . ..  .... ... || |... |          || | | |.
spsptvtsggn.........vtLtCsaeggpppptisWy................ietppelqgsegssssestLtissvt.........sedsGtYtCv

VLN
. |
asN
Ig_2 Immunoglobulin domain 1453-1551 3.1e-06 19.1 Pfam-A 10-77 (80) alignment 
Range on Protein: 1453-1551
Range on HMM: 10-77/80.0
IADNGSDITFTCSANGGPNNTFLWVRSdefenlislssvlqnlpfqntisvqD--------IvdelstitletgttFSIYNINAtEDGGEYLCIVLN-EA
 .. |...|.||.|.| |. .. | .                          .        .              . | |..| ||.| | | . | | 
vvtegenvtLtCqapgnptpkvqwykd.........................geelsqsqna..............lfipnvsa.edsGtYtCrasnseg

GVDSNNTL
.  || . 
skqsnsve
I-set Immunoglobulin I-set domain 1454-1552 2.9e-07 22.2 Pfam-A 12-88 (90) alignment 
Range on Protein: 1454-1552
Range on HMM: 12-88/90.0
ADNGSDITFTCSANGGPNNTFLWVRSDEFENLislssvlqnlpfqntisvqdivDELSTITLE-TGTTFSIYNINAtEDGGEYLCIVLNEAGVDSNNTLL
.  |......|...| |. .. |.. ..  .                       ..  ..| |   .|. |.|... .| |.| | . |.|| .. .. |
vseGesvelectveGepepsvsWakdgselks......................sqrvkvtveeaeytLtIsnvev.sDeGkYtckatnsagkaeakaeL
Ig_3 Immunoglobulin domain 1555-1626 4.5e-13 41.2 Pfam-A 1-73 (75) alignment 
Range on Protein: 1555-1626
Range on HMM: 1-73/75.0
RPVITIQPQEVLTVANVsVSLNCLADSFP-APYYQWR-YTPANGTSQYVPGANESTLVFPSINYEEFGSYVCIA
.|||...|... |..   |.|.| |...| .| ..|   || .  ... .. .||||...| ..|  |.| |.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCva
Ig_2 Immunoglobulin domain 1556-1644 7.8e-08 24.3 Pfam-A 2-80 (80) alignment 
Range on Protein: 1556-1644
Range on HMM: 2-80/80.0
PVITIQPQEvLtVANVSVSLNCLADSFPAPYYQWRYTPaNGTSqyvPGANEstLVFPSINYEEFGSYVCIAAADGIqeTATSDTAIVTV
||.. .|.. .  .. .| |.| |...|.| .||.    . .|   .. |.  |  |....|. |.| | |  ..    ..|..  |||
pvlsapptv.v.tegenvtLtCqapgnptpkvqwykdg.eels...qsqna..lfipnvsaedsGtYtCrasnseg..skqsnsvevtv
Ig_2 Immunoglobulin domain 1653-1727 1.6e-09 29.7 Pfam-A 5-80 (80) alignment 
Range on Protein: 1653-1727
Range on HMM: 5-80/80.0
TPQVNNSFEEQSVTLACGARGGPNNGFQWNytRTGAIVGMDPD--YTLNTSVETAGYYQCIVSN-RAGSDDNTATVNV
...  . .| ..||| | |.| |.  .||   . |...   ..  .. |.|.|..| |.| .|| . .   |. .|.|
sapptvvtegenvtLtCqapgnptpkvqwy..kdgeelsqsqnalfipnvsaedsGtYtCrasnsegskqsnsvevtv
Ig_3 Immunoglobulin domain 1729-1813 2e-11 36.0 Pfam-A 2-75 (75) alignment 
Range on Protein: 1729-1813
Range on HMM: 2-75/75.0
PVITVNPVSINVSIEVenITLNCTARGFP-VPTITWAhndslitsteDEIFIYTNPTSYLRTVLSTIVINSAMANNTGDYVCIASS
|||.|.| ....| .   .||.|.|.|.|  |||.|           .|   . ... ..... || .| |. ....| | |.||.
Pvisvspsptvtsggn..vtLtCsaeggpppptisWy..........ietppelqgsegssssestLtissvtsedsGtYtCvasN
I-set Immunoglobulin I-set domain 1729-1825 3e-11 35.0 Pfam-A 1-88 (90) alignment 
Range on Protein: 1729-1825
Range on HMM: 1-88/90.0
PVITVNPVSINVSIEvENITLNCTARGFPVPTITWAHNDSLITSteDEIFIYTNPTsylrtVLSTIVINSAMANNTGDYVCIASSPfYNSVNSTVAL
|..|  . ...||.. |...|.||..| | |...||...| ..|  .. . .|.         .|..|... ....|.| | |.   . ...... |
pkftqklkdvevseG.esvelectveGepepsvsWakdgselks..sqrvkvtvee.....aeytLtIsnvevsDeGkYtckatns.agkaeakaeL
Ig_2 Immunoglobulin domain 1729-1821 8.6e-11 33.7 Pfam-A 2-73 (80) alignment 
Range on Protein: 1729-1821
Range on HMM: 2-73/80.0
PVITVNPvsiNVSIEVENITLNCTARGFPVPTITWAHNDSLITSTEDEifiytnptsylrtvlstIVINSAMANNTGDYVCIASSPFYnSVNS
||....|    |  | ||.||.|.|.|.| |...| ............                 . |... |.. | | | || . . | .|
pvlsapp...tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.................lfipnvsaedsGtYtCrasnseg.skqs
fn3 Fibronectin type III domain 1835-1918 1.2e-15 50.5 Pfam-A 3-85 (85) alignment 
Range on Protein: 1835-1918
Range on HMM: 3-85/85.0
PVNLSTSDVTSRNLTLSWDEPHHNNAPILGYDIAYtEPDFLGRRNIELTVNGSIEMLFIDGLHPGVSYNFSVNAFNEEGDSGFS
| ||| |.|||..|||||..|.....|| ||.. | ...  |.   | || .. . . . || || .|.|.| | |..| ...|
PenlsvsevtstsltlsWsppkdgggpitgYevey.rekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1934-2019 3.4e-13 42.7 Pfam-A 3-85 (85) alignment 
Range on Protein: 1934-2019
Range on HMM: 3-85/85.0
PQILSSSTINSTAVNVTWMPVPpaQRNGIITGYTIFITTDVEFVNDTTQDIPSAATlQYTFTRLQEYVNYTYTILARTAIGDGPIS
|. || | ..|| ....| | .  ...| ||||..   .. .   ......|. .| ..|.| |... .|.... |... | || |
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 2033-2122 1.4e-16 53.6 Pfam-A 1-85 (85) alignment 
Range on Protein: 2033-2122
Range on HMM: 1-85/85.0
SPPQDFTVDNITSNTFTLSWSPPIerDINGVIDLYTIRYFITEQLGvdpVDPSINVRNVSAtSVTLTDLGNYTEYNISVSAVTVG-VGPSS
|.|....|...||...|||||||   | .| |. |...|  ... .   .. ...| . .  |||||.|  .|||...| ||. .  ||.|
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge...ewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 2136-2226 5.7e-13 42.0 Pfam-A 2-83 (85) alignment 
Range on Protein: 2136-2226
Range on HMM: 2-83/85.0
PPQMVTVVTVSTTSIKVNWAAPPlnMTFGIITRYEILYGEYNATTgqlingtdPIRQVTVTSNTFMYVFNGLQEAREYGFQVRAVTVG-PGP
.|. ..|  |..||. ..| .|.     | ||.||. | | . .         . ...||...|  ....||.. .|| |.|.||. .  ||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 2244-2358 1.5e-10 34.2 Pfam-A 3-85 (85) alignment 
Range on Protein: 2244-2358
Range on HMM: 3-85/85.0
PQNPRAPPQndiGPTSVTLSWDPIPvDEANGDLEYSVNISADDQVSntgnrrkrqmpptltnslqqcitaagtsNMLNYMLPGNQTSLTLTNIAPYTVYS
|.|... ..   ..||.||||.| . |    .  |.|  . ... .                               .. .|...||.|||.. |.| |.
Penlsvsev...tstsltlsWsppk.dgggpitgYeveyrekggge............................ewkeftvprtttsvtltgLkpgteYe

FDVTGVTSAGRGPTS
| |. |. || ||.|
frVqavngagegpeS
fn3 Fibronectin type III domain 2373-2466 6.9e-15 48.2 Pfam-A 3-83 (85) alignment 
Range on Protein: 2373-2466
Range on HMM: 3-83/85.0
PQVLTVVNQsNSTSLLITWYPPECYNGILDGYQIFYRAEQSDGalgnptspvtiPVLATTASNTTQlTQTITGLTPNTEYEVIICATNGAGCGQ
|. |.| .. .|||| ..| ||.  .| ..||.. || ... .           .    |...||. . |.|||.|.||||. . | ||||.|.
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge...........ewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 2593-2662 1.4e-08 28.0 Pfam-A 2-77 (85) alignment 
Range on Protein: 2593-2662
Range on HMM: 2-77/85.0
SVYNLTASSQTSSSILARWDVPLLPNGNITRYDI-YSNSSGTP----F--GSTTSlFYILNGLTTGRTYNVTVRPVT
.. ||..|..||.|.  .|. |  ..|.||.|.. |....|.     |   .||.  ..|.||. |..|...|. |.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavn
Reticulon Reticulon 2838-2876 7.9e-06 12.0 Pfam-A 125-163 (169) alignment 
Range on Protein: 2838-2876
Range on HMM: 125-163/169.0
LGFFMTLIILLIIGAIVAVVLFFVYRKYKSGIYSLVRKG
|| .. |. ||.|| |.|......| ||.  | .||.. 
lgslfslltLlyigvilaftvPllYekyqeeIdalvela
0045450 (Phosphotyrosine protein) phosphatases II 2907-3191 1.1e-92 306.3 In-house 4-305 (307) alignment 
Range on Protein: 2907-3191
Range on HMM: 4-305/307.0
SEKGYVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHP---TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNV-PGSDYINANYI--------DGY
. . .... ..  .|. ..... ...  |. .. .....   . .....| |  |||| .| .|||.||||.  ..  ..||||||.|.        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK-VSSDERTIKQYHF
.. ...|| ||| |... |||||.|||.....||||.|.|.||.||. |||   . ....|.... | .|  | .||.||. ....  .. .||....|.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKC---LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
|.|||.|||... .||.||..|.. . .  . |||.||||||||||||||..   ..|. ....   .|... |. .| .|. .||.. ||.|...||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

YLE
.| 
lll
0039614 (Phosphotyrosine protein) phosphatases II 2910-3193 4e-92 304.1 In-house 12-292 (297) alignment 
Range on Protein: 2910-3193
Range on HMM: 12-292/297.0
GYVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPtKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNV-PGSDYINANYIDGYKK-ENAYIASQGPV
 ..... .....  ..||. .|.  |. ..  . .. .  ...| |  |||| .| .||||||||.  ..| ..||||||.|.|||..  ...||.||| 
ipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PHSIVDFWRMIWEQKTETVVMLTNLEEKGRiKCHLYWPPPDKrvvVHGQIRIQLQEELSLTDYTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEHPTT
|... |||||.|||.....||||.|.|.|| ||. |||.      ..|.... | ..  | .||.||.....  .. .||......|.|||.|||.....
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslel

LLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
||.|...|.. . .  . |||.||||||||||||||..   ..|.  ....|... |. .| .|. .|||. ||.|..|||||.| ..
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2910-3227 1e-76 253.2 In-house 3-324 (325) alignment 
Range on Protein: 2910-3227
Range on HMM: 3-324/325.0
GYVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
| ..| ..  || . .|.|.  |. |.  . ..   .| .. .|.|  |||. |. |.|.||| |    . | ||||||.|.  .|| . ..|.| | ..
gsiavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlta

SIVDFWRMIWEQKtETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLL
.| |.||.. . .  .||...|  ..|  .|  |||      .  | ....|.    ..||  | . ..     . |..||... ||.|.||...|.||.
tindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli

RFIHKVQ------RENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVK
 ... |.      . | | ..|..|||||||||||.||.. . ......   .||..||. .|  |  ||.|  |||.|..|| |.. .|.|.|    ..
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfe

EQFRLLNEVFDkEEGKTRLEKEFD
 ..  |.|       |  .||||.
aklsslqernp.ltqklniekefe
subfamily_PTPRB_pd Subfamily PTPRB 2911-3194 2.9e-105 346.5 In-house 6-289 (293) alignment 
Range on Protein: 2911-3194
Range on HMM: 6-289/293.0
YVSVGDFPAHVANMHANDDYLFSVEYPTVEPQ-HHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
 ... .| .||..|.|..|. || || ...   .. ...|.... |. |||| || .||||||||..  . .||||||||||.||. .. .||.|||.|.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEHPTTLL
.. |||||.||.|....||||.| |||..||. |||  |.. |..|.|...|..| .|.|..||......  ...||...|||||||||.||||...|||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

RFIHKVQREN--PKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
.|...|...    ....|.|||||||||||||||..   .|.| .. ..||. .|...| .|...||||.||||||...|..|. .|
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0051299 (Phosphotyrosine protein) phosphatases II 2911-3190 5.1e-102 336.4 In-house 4-286 (288) alignment 
Range on Protein: 2911-3190
Range on HMM: 4-286/288.0
YVSVGDFPAHVANMHANDDYLFSVEYPTVEPQH-HPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
 .|| ..  .| ...||. ...  |. .. ..  ..|  |...| |  |||| .| .||||||||.  ..|.|||||||.|||||......|| ||| |.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK----VSSDERTIKQYHFTSWPDFGVPEHP
.. |||||.|||.....||||.|.|.||.||. |||.  . ....|.|.. | .| .| |||.||. ....     .. .||....|.|.|||.|||..|
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
. ||.|...|.. .... ||||||||||||||||||.. . ..|.. ....|....|. .| .|..||||. ||.|...||||||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 2911-3207 9.9e-91 299.0 In-house 3-303 (307) alignment 
Range on Protein: 2911-3207
Range on HMM: 3-303/307.0
YVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHP-TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
 ... | .  . . . . |...  || ..| .. . .  .... .||.|||| .| |.|. ||||.. .    ||||||..| |||... .||.|.||  
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPdkRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKV-----SSDERTIKQYHFTSWPDFGVPEH
 | ||||||.||. ...|||.||.|| | ||. |||      | .|.| ..| .| . .||.||.... .|        |.| . |||.|.|.|. |||.
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKE
...||..|..|.  . .| .|.||||||||||.|.|....  .||.   ...||...|. .| .| ..||  .||.|.. |||.| . |.|... .....
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

QFR
...
aie
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2911-3199 6.8e-69 227.2 In-house 9-293 (297) alignment 
Range on Protein: 2911-3199
Range on HMM: 9-293/297.0
YVSVGDFPAHVAN-MHANddyLFSVEYPTVePQH-HPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKenAYIASQGPVP
 . . ||.. | . .|..   .|| |.  . |.    ..  ...  |  |.||.||  || |||||    . | |||.|| .. |.|.   .|..| | .
piplsdfatlvqknrhtd...vfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

HSIVDFWRMIWEQKTETVVMLTNLEEKGRiKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPE--HPT
 .. |||.|...... |.|||....|. . ||  ||.  || |.  |.. ..|.   . . .  |......  .  .| .|||.|..|||  |..  . .
atvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas

TLLRFIHKVQRENPKNAG-PVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSA
.|| .|. |. .  .||  |..|||.||||||| ..||   . .. . | .||...|. .|  | ..|||. || |.. |.||.| . .|.. |
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_PTPRD_pd Subfamily PTPRD 2912-3237 4.6e-139 459.6 In-house 5-327 (564) alignment 
Range on Protein: 2912-3237
Range on HMM: 5-327/564.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
..| ....|||...||.|. |. || ..|.... |..| ..| |  ||||||| |||||||.|.. ....|||||||..||||.|..||||.|||....|
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPdKrVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRF
 |||||.|||...|.||||.|||||. ||| |||   .    .|.. ..|.||  |.||.||||.|..| ||. |...|.||||||| ||||..|.||..
edFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

IHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNE
|.||.. |...|||.|||||||||||||||.|.. ...| . | .|||..|. .|  | .||||| ||||||.|.||.|.||.|||.....|.... |.|
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLae

VfDKEEGKTRLEKEFDNIQETIHREP
| ..... | ||.||.... . . |.
v.eedtemtgleleFqrLatakeiel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2912-3228 1.6e-123 406.8 In-house 2-317 (318) alignment 
Range on Protein: 2912-3228
Range on HMM: 2-317/318.0
VSVGDFPAHVANMHANDDYLFSVEYPTV-EPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHS
.|| |.  ||...... . |.| ||  .   ....|.  . .| |. ||||||| ||||.||||..  ...|||||||||||||....||||.|.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

IVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
| |||||.|||.. ..||||..||.|..|.| |||  .|    .|.....|.||..|.||..|.|..... ....|...|||.||||| ||||....|| 
ieDfWrmvWeqnsavivmltqeeergkakvhryWP..skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

FIHKVQREN-PKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLL
.. .|.. . ...|||.||||||||||||.||... ....| . . .|....|. .| .|  ||||| ||.||.|.|||.|..|.|||.|...... | |
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

NEVfDKEEGKTRLEKEFDN
.|. | | |.|... ||..
req.dpesgttemdaefqr
subfamily_PTPRG_pd Subfamily PTPRG 2912-3204 9.5e-106 349.2 In-house 1-301 (563) alignment 
Range on Protein: 2912-3204
Range on HMM: 1-301/563.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPT---KDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGS-DYINANYIDGYKKENAYIASQGPV
| | .|  |||..||..|  || |.  .. .. ..    ...|.|.|  |||| || |||.|||||.. |.. .. |||||||||||.|..|.||.|||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH---KVSS---DERTIKQYHFTSWPDFGV
.. . |||||||||.....||.|||.|.|| ||. |||     ..  |.....|.||  |. ||.||.....   |  .   .|....|||.|.||| ||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv

PEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSARE
|||..  | |..| .. |...|||.|||||||||||||.| ..  ..|| ...  ....|.. .| .| |.|||| ||||.|||||| .  .|||..| .
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq

VKE
|.|
vee
0043336 (Phosphotyrosine protein) phosphatases II 2912-3190 2.1e-95 314.6 In-house 2-277 (278) alignment 
Range on Protein: 2912-3190
Range on HMM: 2-277/278.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
.|| |.. .......|. .|.. |. ..  ....|.. ...|.|  |||| .| .||||||||. ......||||||.|.|||.. ...||.||| |...
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRF
 |||||.||....|.||||.|.|.||.||. |||   . ....|.... |..| .| |||.||. . .. .. .||. .||...|||.||||....||.|
edFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
...|.. .... |||.||||||||||||||..   ..|. .....|... |. .| .|. .|||. ||.|...||||||
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2912-3202 1.4e-94 311.7 In-house 4-295 (305) alignment 
Range on Protein: 2912-3202
Range on HMM: 4-295/305.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQhHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
... |. |.. ......|  . ..| ..  . . . | ...  |. |||...|  .|..|..|||..... ||||||.|.||||....||..|||... .
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
.||||.|.| |..|.||||.| | |. ||. |||   .... .|.. ..|..| . .||..| ...   . ....||. ||..|.||| |||. .|.||.
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FIHKVQRENPKNAG-PVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREV
.|..||..  |. | |..|||||||||||.||... .....   . .|... .. .| .|  |||| .|| |.|||| |...||.|..    .
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
subfamily_PTPRK_pd Subfamily PTPRK 2912-3226 6.1e-93 306.1 In-house 4-312 (314) alignment 
Range on Protein: 2912-3226
Range on HMM: 4-312/314.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQhhptKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
. | |   ..| ..... | |  || ..        ||... .|  |||. .| |||.|||.|.   . | ||||||..||.||. .|.|. |||... .
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVvHGQIRIQLQEELSLTDYTIRTFSLQH--KVSSDERTIKQYHFTSWPDFGVPEHPTTLL
 ||||....... ..||||.| |.||.||  |||  ..  | .|.|...| |   |... .|.|....  .  .. |...|..|..|||..|| . |.||
kdfWrlvydencasivmltelvevgrvkClkyWP..edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

RFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLL
.....|.  ....||..||||||| |||||||.|.  .. |  .. .|..| |...| |.  ||.|| ||.||.|..||   |||| . . |.|  .   
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles

NEVfDKEEGKTRLEKEF
... | .   ..|..||
irl.dpqtnssqlkeef
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2912-3197 1.4e-73 242.3 In-house 2-285 (287) alignment 
Range on Protein: 2912-3197
Range on HMM: 2-285/287.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDAT--QHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVPH
..|. |   ||. ||. .  |.  . ..|   .  .. |    ..|  |||...|  .|  || | .  .    ||||| .|||||...|.|....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehp....dyinavfidgykekkafiiaesPmfn

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKrvVVHGQIRIQLQEELSLTDYTIRTFSLQHKV-SSDERTIKQYHFTSWPDFG-VPEHPTT
 ...||..|.... ...|||....|. . .|. |||  .   || |. .|.| .|   ..|..|.. ...|  ..|....|||..|.|.. | |.|. | 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEV
|| . .... .  .  ...|||||..|||...|. .   |..      .|... ..|.| ..  .||| .||.|| |..||||...|| .
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2912-3195 6.9e-73 240.0 In-house 2-288 (290) alignment 
Range on Protein: 2912-3195
Range on HMM: 2-288/290.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQ-HHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPG--SDYINANYIDGYKKENAYIASQGPVP
. |..|  .||| ||. .  |  .. ...   .. |      ..|  .||.|||  ||  |. | . .. .    .|||| ||.|||....||| ||||.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

HSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVvvHGQIRIQLQEELSLTDYTIRTFSLQHKVS-SDERTIKQYHFTSWPDFG-VPEHPT
. .||||..||..|.  .|||||  |.|. ||. |||  | .    |...|.|..| .|..|..|......| |  ......||..|.|.. | |... |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

TLLrFIHKVQR-ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGET
 ||  |..... .  .  ...|||||..|||...|...   |..       |... ..|.|  .  .|||. || .|.. .|.||.. ||
ill.vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2912-3230 6.4e-65 214.0 In-house 4-275 (392) alignment 
Range on Protein: 2912-3230
Range on HMM: 4-275/392.0
VSVGDFPAHVANMHanDDYLFSVEYPTV-EPQHHPTKdATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHS
. | .||| | . .     ||. |.  . .|. .|.. ..|...|  |||| ||  || .||||    ..| |||.|| ||.... |.|||||||| . |
ipvaqfpafveknr..hsalffeefhdlpgpdiypqt.vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

IVDFWRMIWEQKTETVVMLTNLEEKGrikchlywpppdkrvvvhgqiriqlqeelsltdytirtfslqhkVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
. |||||...... |..|.|.|.|                                                 | ||. |.||| ||| .||.| ..||.
lddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllk

FIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLN
||..|. .  . . |...||||||||||  |.| . . .    . .|..|||  .| .| .||||. || ||. |.|| |   .| .    . .. . |.
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

EVFDKeEGKTRLEKEFDNIQ
   |  .....  ||| ...
tssdG.dvrskqlkefrslk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2913-3226 3.4e-103 340.1 In-house 6-318 (319) alignment 
Range on Protein: 2913-3226
Range on HMM: 6-318/319.0
SVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIV
 | ..  .. ..... . |.  |. ...     | | .....|  |||| || |||..||.|.| ..|.|||||||..||||......|| |.|. . | 
evqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentie

DFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRF
|||||.||... .|||||.| ||...|.. |||  .. ... |.. ..|.||  | || || ..|..| |    |..|....|.||| .|||. |.|| .
dfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

IHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLN
......   | ..||.|||||||||||||||...  ....     ||....|. .|  | .|||...||.||..||||..|.|.||.  ........ |.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

EVfDKEEGKTRLEKEF
|  . . |.| ||.||
ek.vadtgetgleref
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2913-3228 6.7e-82 269.8 In-house 4-314 (315) alignment 
Range on Protein: 2913-3228
Range on HMM: 4-314/315.0
SVGDFPAHVANMhaNDDYLFSVEYPTV-EPQHHPTKdATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
 | .||| | .       ||| |.  . .|. .... ......|  |||| ||  .|..||||    . | |||||| || ......|||||||| . |.
pvaqfpafvnkn..rhtalfseefhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFslQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRF
 |||||....|. |.||.|...|  .|||  |||  .   |  |.|...| .  . || ..| .    . | . ||. |..|| ||| ||... ..||..
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllkl

IHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNE
|..|. .| |.  ...||||||||||| .|.|   ..|| ... .|..|||. .|  | ..|||| .| ||.||.||.|   .| .    . .... |. 
ikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht

VFDkEEGKTRLEKEFDN
  |  .|.... |||..
svd.gsgrskmtkefet
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2913-3005 6.3e-16 52.3 In-house 6-95 (95) alignment 
Range on Protein: 2913-3005
Range on HMM: 6-95/95.0
SVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgSDYINANYIDGYKKENAYIASQG
 |  | .|| .||.| |  |  |. ..      .  .     |  |||. ||  || .|| ||   .   |||||| ..||| . |.|||.||
hvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
0040438 (Phosphotyrosine protein) phosphatases II 2914-3206 8e-102 336.0 In-house 2-292 (317) alignment 
Range on Protein: 2914-3206
Range on HMM: 2-292/317.0
VGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVD
| |.. ..  ....| .... |. ..  ....| . ...|.|  |||| .|  ||||||||. ......||||||.|.||... ...|| ||| |... |
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIH
||||.|||.....||||.|||.||.||. |||   . ....|.....|..|  | ..|.||. .... .|..||....|.|.|||.|||..|..||.|..
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

KVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQF
.|.. .... |||.||||||||||||||.. . ..|.  ....|... |. .| .|. .|||..||.|..||||||| ...| ..| | |  .
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2915-3237 4.2e-80 264.3 In-house 5-322 (515) alignment 
Range on Protein: 2915-3237
Range on HMM: 5-322/515.0
GDFPAHVANmhANDDYLFSVEYPT-VEPQHHPTKdATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVD
 .||| |.   ..   ||| |.     |. .|    .|   |  |||| ||  || .||||    . | |||.|| || ... ..|||||||| . |. |
aqfPafvnk..nrhttlfseefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvdd

FWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIH
|||....... |..|.|.|.|  .|||  |||      |  |.|...|    . |. ..|.. . .  ..| ||. |.||| ||| |||.| ..||..|.
fWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklik

KVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNEVF
.|. .. . . |...|||||||||| .|.|   . .. . . .|..|||. .| .| ..|||. || ||..|.||.|   .| .      .... |    
evkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssg

DKeEGKTRLEKEFDNIQETIHREP
|  .|.... |||. ..  .   |
dg.rgrskmtkefqtlkslcpdpp
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2915-3207 1.1e-69 230.0 In-house 5-296 (439) alignment 
Range on Protein: 2915-3207
Range on HMM: 5-296/439.0
GDFPAHVANMHANDDYLFSVEYPTVEP---QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
 .|  || ... |.. .|. .. ...    ...     . .  .  |||| ...|.||.|| | | | || | |||||||.|| ... |||.|||  .. 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

VDFWRMIWEQKTETVVMLTNLEEKGRikchlYWPPPDKrvVVHGQIRIQLQEELSLTDYTIRTFSLQHK--VSSDERTIKQYHFTSWPDFGVPEHPTTLL
 ||||...|.|| |.|||||| |  .     |||  ..  |..|.| .. . .. | .|.|| | .  .   .  |||. |.|...|||  || . . .|
ddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

RFIHKVQRENP-KNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFR
 |.. ..  |  .. |||||||||||||||| |..   ..|.   . .||   |. .| .|  |||. .||.||..|.|| .  |.. |.  |.| .| 
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefn
subfamily_PTPRA_pd Subfamily PTPRA 2918-3225 1.2e-99 328.3 In-house 20-329 (330) alignment 
Range on Protein: 2918-3225
Range on HMM: 20-329/330.0
PAHVANMHANDDYLFSVEYPTVEP-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWR
   .    |.|  ||  |. ..   . . | ..... .|  |||. ||  ||.||| |..   |. |||||| .|||||. . .||.|||  ... ||||
eeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwr

MIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH----KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFI
||||||. |.||||.|.|. . ||. |||  |. .| .|.||.....|  | |||.| | .|.    .   ..| ..|.|||||||.||| .|  .|...
miweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkll

HKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNEV
.||.. |...|||.|||||||||||||||...  ....   . .|...||...| .|. ||||. || ||. .||||   |.||. .  ...... | . 
kkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk

FDKEeGKTRLEKE
  .   |. ||.|
itgt.dkigleee
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2918-3196 7.3e-62 203.8 In-house 6-299 (301) alignment 
Range on Protein: 2918-3196
Range on HMM: 6-299/301.0
PAHVANMHANDdylFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPN--VPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFW
 .|||..|.|.   |. .| ... ... . . . . .|.  ||. ||. ||. |. |.. ||  .   .||||.|||||......||.|||. . .||||
gthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH-------------KVSS--DERTIKQYHFTSWPDFG
|.||..|. ..||.|||.|. . ||. |||  ...    |.. ..|..|  . |..|| ....              ||.|  . ... |.. |.||. |
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

VPEHPTTLLRFIHKV-QRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETE
|   | | |. |..| .|..  . ||||||||..|.|.|.....|  . |       |... ....|  .  .|.|  ||..|.|.. .||.. .|.
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2919-3190 3.7e-93 306.7 In-house 10-279 (288) alignment 
Range on Protein: 2919-3190
Range on HMM: 10-279/288.0
AHVANMHANDDYLFSVEYPTVEP-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRM
|.||...|..   || || .. . ... ...|.... || |||| || .||. ||||.. ....|.|||||.||||.||...|||.|||..... |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRvVVHGQIRIQLQEELSLTDYTIRTFSLQhkVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQR
..|.||.|.||||.| |.|. ||. |||  ||  . .|.. ..|.|.  |.|.. |.. |.   . .|..|.||....||| ||||  . || ....|. 
vyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
 |....||..||||||||||||||.. . |...   . .|. ..|. .| .| ..|||. ||.||...||.  
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2919-3191 1.6e-92 304.6 In-house 4-277 (281) alignment 
Range on Protein: 2919-3191
Range on HMM: 4-277/281.0
AHVANMHANDDYLFSVEYPTVEP-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRM
.|......||.  |  || ...  . . |  |.....|  |||| ||.|||..|||.|.. .   .||||||...|||.|..|||.|||||.|.|.||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQKTETVVMLTNLEEKGRIKCHLYWPpPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLqHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKV-Q
.|||| ...||.|.  |.|..||| |||  |.  .  |..... ..| . . |  |.|.| .. |...|...| ..|.||| |||. .. || | ..| .
vweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

RENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 ...|.  |.|.|||||||||||.|..   .... .. . ||. . |...| .| .|||| .|| |.. |.|..|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2920-3211 5.1e-85 280.2 In-house 14-301 (315) alignment 
Range on Protein: 2920-3211
Range on HMM: 14-301/315.0
HVANMHANDDYLFSVEYPTVE-PQHHPTkDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMI
.||. .|.    |  .| ..   | ||  | ...  |  |||| || |||.|||.|    | |.|||.|||.||||.|.. |||.||| . |. ||||..
yvaqkkastkngfkqdyesipggqlhpl.dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv

WEQKTETVVMLTNLEEKGRIKCHLYWPppDKrVVVHGQIRIQLQEELSLTDYTIRTFSLQHKvsSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRE
.|..  ..|||||| |. . |.  |||  ||  |..|.| . ...|   |.||.||.|   .  .. |.. |.|.||||| |||.. ..|. .| .|.. 
feedigkivmltnlvegekrkaekywp..dk.kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqh

NPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFR-LLNE
. ...|..||||||||||||||||... ..|.   . .|.|||.. .|  |  |||. .|| ||.||||| . ||.| .. .   ...  ||  
htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllap
0050432 (Phosphotyrosine protein) phosphatases II 2923-3195 5.6e-99 326.6 In-house 37-304 (308) alignment 
Range on Protein: 2923-3195
Range on HMM: 37-304/308.0
NmhANDDYLFSVEYPTVEPQHH-PTKDATQHPDNAIKNRYANISAYDHSRVKLtedpNvPGSDYINANYIDGY--KKENAYIASQGPVPHSIVDFWRMIW
.  |.| .|.. |. ..  .   .. .....|.|  |||| .| .||||||||    . .|||||||.|.|||  |.....|| ||| |... |||||.|
k..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

EQKTETVVMLTNLEEKGRIKCHLYWPPPDK-RVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRE
||.....||||.|.|.||.||. |||.  .  ....|.... | .| .| |||.||. |... ....||....|.|.|||.|||..|. ||.|...|.. 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

NPKnaGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGET
.|.  ||.|||||||||||||||.. . ..|.   ...|... |. .| .|..||||. ||.|...||||||.. .|
lpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2924-3197 7.3e-94 309.3 In-house 21-297 (298) alignment 
Range on Protein: 2924-3197
Range on HMM: 21-297/298.0
MHANDDYLFSVEYPTVEPQHH----PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIW
.....   .. |. ...   .     .|.....|.|  |||||.| |.|.||| |... .   |||||| ....||..||.||.|.|......|||||..
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQReN
|.. .|.||||||||....|.| |||  |..   .|.|...|... . .|...|.. ...| ...||...| ||||||| ||||. |..| ...||.. .
eedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.s

PKNAG--PVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEV
...||  ||.|.|||||||.|||| |.  ....   . .|... |. .| .|. .||||.||.||..| ||.|.....|.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2929-3199 1e-77 256.6 In-house 33-300 (319) alignment 
Range on Protein: 2929-3199
Range on HMM: 33-300/319.0
DYLFSVEYPTVEPQHHP--TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETV
   . ||.  .  .  .  ... .  ..|  |||. || |.|...|||     . .|||||| ...||.... |||.||| . .. ||||||||... |.
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLTnleekgRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA--
|.||      . ||  |||   | |. ...  ....      .|..| . | .     | | |.|.||  ||| |||..|. |.|...||.  . |.   
vllt......kdkcsqywp..lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSA
 ..||||||||||||..|.. . .... . | .|.||||. .| .|  .||  .|| ||. ||||    | ..|. 
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvam
subfamily_PTPN14_pd Subfamily PTPN14 2934-3191 4.2e-59 195.0 In-house 27-297 (300) alignment 
Range on Protein: 2934-3191
Range on HMM: 27-297/300.0
VEYPTVEPQH-HPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVpGSDYINANYIDGY--KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLT
.||  . ... . . .... |.|| |||. ..  |...||.|.   .   ..||||  |      ||  ||..|||... . |||.|.|||... .||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLEEKGRIKCHLYWPPP--DKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQR----EN----P
. ||.|. |.. |.|     |. | .|. ... .   . . .. ... |.|  |..|||.    .| ||| |||| ... | ....||      |    .
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

K-NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
| .  ||.|||||||||||  |.    |. .   . .|| . .. .| .| ..||| ||| |....|..||.
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2934-2993 3.4e-11 37.1 In-house 26-85 (440) alignment 
Range on Protein: 2934-2993
Range on HMM: 26-85/440.0
VEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDG
 |.  .        | .  |.| .|||| || ||||||| | |   || |||||| ||.|
dewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2938-3189 6.7e-21 69.2 In-house 30-278 (303) alignment 
Range on Protein: 2938-3189
Range on HMM: 30-278/303.0
TVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEdpnvpgSDYINANYIDGYKKENAyIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGR
 |     |.    |  .|  |||....   |||.|||..      | || |.|..   . .| | .| |..|.  |||.|| |||   |..|    |  .
kvvsylppsvsknqfvknmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydk

IKCHLYWPPPDKRV-VVHGQIRIQLQEELSLTD-YTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEH-PTTLLRFIHKVQRENPK--NAGPVVVHCSA
.  .  .|  .  .   .  ||.    .. |.| ....  |.     .    .. .|. .||   .| .    ... | ..|    |  .. | |    .
lggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn..gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GVGRTGTFITISC-QIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
|.||.|||  .   ..    .. .||. . .. .|  |   ||  .|. ...  | |.
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2938-3061 6.8e-12 39.5 In-house 80-195 (244) alignment 
Range on Protein: 2938-3061
Range on HMM: 80-195/244.0
TVEPQHHPTKDATqHPDNAIKNRYANISAYDHSRVKLTEDpnVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGR
 . |.    |||   |.|. ||| .    .| .|| |..     |  |||| ..    .   || .| |.  . .|||.|. |.. . .|.|  .||.  
iirpdpsvmkdaf.npnnswknregaglpfdfnrvplskg..smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede

ikchlYWPPPDKRVVVHGQIRIQL
     |||  .       .| . |
.....ywpdseplewyeeditvtl
0046845 (Phosphotyrosine protein) phosphatases II 2939-3195 3.7e-96 317.1 In-house 12-279 (284) alignment 
Range on Protein: 2939-3195
Range on HMM: 12-279/284.0
VEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNV-PGSDYINANYIDGY-----KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNL
. . .. . .....| |  |||| .| .||||||||.  ..  ..||||||.|.|||     ......|| |||.|... |||||.|||.....||||.|
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltel

EEKGRIKCHLYWPPPdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKV-SSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENP--KNAGPVVVH
.|.||.||. |||.  . |...|.... | .|    |||.||..|...  .. .||....|.|||||.|||..|. ||.|...|.. ..  .. ||.|||
vengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVH

CSAGVGRTGTFITISCQIQQILDRK---CLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGET
||||||||||||.. . ..|.  ..   ..|... |. .| .|..||||..||.|...|||||| .. |
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0047943 (Phosphotyrosine protein) phosphatases II 2940-3190 7.3e-94 309.5 In-house 22-272 (273) alignment 
Range on Protein: 2940-3190
Range on HMM: 22-272/273.0
E-PQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLtedpNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRI
   ... |. ....|.|  |||| .| .||||||||    . .|||||||.|.|||......|| ||| |... |||||.|||.....||||.|.|.||.
lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgre

KCHLYWPPPDKR-VVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVG
||. |||.     ....|.... | .| .  |||.||. |... ....||....|.|.|||.|||.... ||.||..|.. . .  . ||||||||||||
kcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
||||||.. . ..|.  ....|... |. .| .|. ||||. ||.|...||||||
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 2940-3193 1.5e-83 275.3 In-house 39-300 (306) alignment 
Range on Protein: 2940-3193
Range on HMM: 39-300/306.0
EPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTeDPNVPGSDYINANYIDG--YKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGR
| ..  ... ...|.|. |||| ||  .||.||.|. .|.||||||||||||..   .....|||.|| ... . |||||.|..... .||.|.  |.|.
eakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk

IKCHLYWPPPDKRVVvHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA----GPVVVHCSA
 ||  |||   ..   .|.|...  .| ||.||..|..|... | ...||.. ||||.|||| |||..| ..| |...|.|.. . .    ||.||||||
ekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsa

GVGRTGTFITISCQIQQILDRKC---LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
|.||||||| | . ...|  ...   .||...|.|.|  |  .||||.|| |.. |. .|.|  
GiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
0036941 (Phosphotyrosine protein) phosphatases II 2941-3200 1.1e-95 315.6 In-house 24-287 (297) alignment 
Range on Protein: 2941-3200
Range on HMM: 24-287/297.0
P-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLtedpNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIK
| .. ....... |.|  |||| .| .|||.||||    . .|||||||.|.|||. ....|| ||| |... |||||.|||.....||||.|.|.||.|
pllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

CHLYWPPPDKRVVVHGQIRIQLQEELS--LTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVG
|. |||.    ....|.....|... .  |.|||.||. .... ....||....|.|.|||.||||.|..||.||..|.. ...  . |||.||||||||
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RTGTFITISCQIQQIL---DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAR
|.||||.. . .||.     ....||...|...| .|...|||. ||.|...||||.| ...| ....
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2941-3192 7.9e-76 249.7 In-house 15-270 (274) alignment 
Range on Protein: 2941-3192
Range on HMM: 15-270/274.0
PQHHpTKDATQHPDNAIKNRYANISAYDHSRVKL-TEDPNVPGSDYINANYIDGYK-KENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRI
|  . ... .. . .. |||| .|   ..||| | .|... . |.||||||| ||. ...||.| |||.|. . ||||||...... .||||.|.|. . 
Plnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

KCHLYWPPPDKR--VVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSsdERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQREN---PKNAGPVVVHCSAG
||. |.|   .      .|.. |. .. ..  ||..|...|..  .  ||..| | .|.|||  .|....|||.....|....    ....|||||||||
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLEC
.|||| ||.||  ..|. ... .|. . |  .|  |  ||||. || .|| || .||..
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2941-3192 2.4e-40 133.4 In-house 29-273 (288) alignment 
Range on Protein: 2941-3192
Range on HMM: 29-273/288.0
PQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKC
|.. . . .... .|. ..|| |.   | .||||..||.     ||.|| .   | ..  | .| |.   |  .|.|. |.  | .|||..| |||. | 
pneasidiidsfianptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks

HLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERT-IKQYHFTSWPDFGVPEHPTTLLRFIHKVqrenPKNAGPVVVHCSAGVGRTGT
  |.|    . .  |..  . ... .  | ...   |. .   .|.  .|. |.  |.| ||||   . ||... .     .   |.|||.|||||||||
aeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgt

FITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLEC
.| |   ....     | | ......|  |   .||| ||...|  .||.|  
lililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2942-3191 1.8e-22 74.2 In-house 38-286 (302) alignment 
Range on Protein: 2942-3191
Range on HMM: 38-286/302.0
QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVP---HSIVDFWRMIWEQKTETVVMLTNLEEKGRi
.  ..   . . .|  ||.  .. ..|. .|||.. |.    .|.||  ..  . ..  | .| |.    .|. .||||....|  .||.|   ||  . 
mkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.

KCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTiRTFSL--QHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGR
  . ..|      . .|....  .   .  . .   ...    .  |.   .. |..| |..  ||.. ..| . ..||  .. |   ..|.    |.||
tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGR

TGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 |.|.|    .... . |   | . |.|.|  |. .|..  ||.... ||| |. 
agafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
0045098 (Phosphotyrosine protein) phosphatases II 2943-3194 2.1e-83 275.2 In-house 21-276 (278) alignment 
Range on Protein: 2943-3194
Range on HMM: 21-276/278.0
HHPTKDATQHPDNAIKNRYANISAYDHSRVKltedpnvpgsDYINANYIDGYkkENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHL
.  .    . ..|. |||| .| .|||||||          |||||.|||||   ...|| ||| |. . |||||.||......||||.|.|.||.||. 
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK----VSSDERTIKQYHFTSWPDFGVPEHP--TTLLRFIHKVQRENPK-------------NA
|||.  . ....|.... |..|  | |||.||. ...      .  .|.....|...|||.|||..|  . .|...  ... . .             . 
ywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

GPVVVHCSAGVGRTGTFITISCQIQQIldRKCLDIYNFVQSMRYRRCF-MVQTEAQYIFIHDALLEYLECGE
|||.||||||||||||.. . . ....   . .|... |. .| .|.. .||.. ||.|....|||.|..|.
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_PTPN1_pd Subfamily PTPN1 2943-3192 1.2e-67 222.7 In-house 21-273 (290) alignment 
Range on Protein: 2943-3192
Range on HMM: 21-273/290.0
HHPTKDAtQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHL
..||..| ..| |  .||| ..| |||||.|| .. |    |||||. ..  . .  || .|||.|. .  ||.|.||||. .|||| .. ||..|||. 
dfptrea.klpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPPPDK--RVVVH-GQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQREN--PKNAGPVVVHCSAGVGRT
|||  ..   ....  .....| .| .   ||.|.. |. . . . |.| ..|.|.|||||||| |...|.|..||..     .. ||.|.|||||.||.
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GTFITISCQIQQIL---DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLEC
|||. . . . .|    | ...|| . .  .|  |  ..||  |  | . |.||   .
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
DSPc_SM00195 2945-3190 1.6e-90 298.4 In-house 16-262 (263) alignment 
Range on Protein: 2945-3190
Range on HMM: 16-262/263.0
PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
 ... .... |  |||| ||  |||.||||..... .||||||||||.|..|...||| ||| |. . |||||.||.|....||||. ||.|..||. ||
ketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDKRVVVHGQIRIQLQEELSLT-DYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITI
|   ..  ..|.|...|.|. .   ....||..|...  ...|...||....||| |||.... .|.....|. .. .. ||.||||||||||||||.||
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

SCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.. .... . | .|| . |...|  |. ||||..||.||..|.|||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2945-3190 1.6e-90 298.4 In-house 16-262 (263) alignment 
Range on Protein: 2945-3190
Range on HMM: 16-262/263.0
PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
 ... .... |  |||| ||  |||.||||..... .||||||||||.|..|...||| ||| |. . |||||.||.|....||||. ||.|..||. ||
ketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDKRVVVHGQIRIQLQEELSLT-DYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITI
|   ..  ..|.|...|.|. .   ....||..|...  ...|...||....||| |||.... .|.....|. .. .. ||.||||||||||||||.||
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

SCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.. .... . | .|| . |...|  |. ||||..||.||..|.|||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRN_pd Subfamily PTPRN 2945-3188 8e-59 193.8 In-house 46-290 (297) alignment 
Range on Protein: 2945-3188
Range on HMM: 46-290/297.0
PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYI-DGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLY
 ||.......|. |||.... .||||||||.|. .   ||||||  | |   .. ||||.|||..... |||.|.||| .  .|.||.|||.|  .|. |
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPppDKRVVVHGQIRIQLQ-EELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFIT
||  |.   |..   ..|  | .   || .|.| |.   .|. ||. |.|| |||. |||  . .|| |  ||..     . |.|||||.|.||||..| 
wp..deGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyil

ISCQIQQILD-RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
|   ....|   | .||   .. .| .|  .|.|..|. |.  |. |
idlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_eak_pd Subfamily eak 2945-3103 2e-12 41.2 In-house 42-196 (332) alignment 
Range on Protein: 2945-3103
Range on HMM: 42-196/332.0
PTKDATQHPDNAIKNrYANISAYDHSRVKLTEDPNVPgSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
 ..  |.  ..  .|   .|  ||.  |.||     .   ||||  ..  .  . || .  .    .  ||.|. |||. ..|.| .  |..  |   |.
lsisetarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLqhKVSSDERTIKQYHFTSWPDFGVPE
|   . .. .|.. .. .| .    .  | . |  ..  .   .. |..  | .. .| 
pdktreelkfGildverkefvkrniletrllel..skGnethrvlhykvfGwtettlpk
subfamily_PTPN9_pd Subfamily PTPN9 2946-3190 2e-80 265.0 In-house 33-290 (297) alignment 
Range on Protein: 2946-3190
Range on HMM: 33-290/297.0
TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
| .|.... |  ||||...  ||..||.|.. .. . |||||||..||||...|.|| |||... . |||||.|||.. ..|| | ..|.||.||  |||
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

PPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQREN-------------PKNAGPVVVHCSA
. .. .  .|.....  |  .  ||..|.. ...   ...|..  . |.||||.|||.  ..|| ...||...              . .  |.||||||
leeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
|.||||||||.   .... .   .|. . |. .| .| |..||. || | . |.||| 
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2946-3191 1.5e-63 209.3 In-house 11-265 (270) alignment 
Range on Protein: 2946-3191
Range on HMM: 11-265/270.0
TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKE-NAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
..|  ..  ..  ||||.|    ..||.| |  . . . ||||||. |...| ..|||..||.| .. .|||||||.|....||.|.|||||| ||  ||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PPPDKR--VVVHGQIRIQLQEELSLTDYTIRTFSLQhkVSSDERTIKQYHFTSWPDFGVPEHPT------TLLRFIHKVQR--ENPKNAGPVVVHCSAGV
|.  |.   . .|.|..  ..|   . | ..   |.   ...|| .  .....||| |||...        ||. ...|.|  .. ..|.|..|||||||
paepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
|||||.|..   .. .  .| .|. . .. .|  |. .||.  || |.. |..|| |
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0040439 (Phosphotyrosine protein) phosphatases II 2947-3190 4.2e-86 283.8 In-house 3-246 (249) alignment 
Range on Protein: 2947-3190
Range on HMM: 3-246/249.0
KDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPP
.. ...| |  |||| .| .||||||||.  |....||||||.|||||.  ...|| ||| |... |||||.||.. ...||||.|.|.||.||. |||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

pdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITIS
  . ....|.....| .. .. |||.||. |...  ...||......|.|||.|||... .||.||..|.  . .  . |||.||||||||||||||.. 
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

CQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
  ..|.  ....|... |. .| .|. .||.. ||.|...||||.|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 2947-3191 1.5e-80 265.2 In-house 32-278 (290) alignment 
Range on Protein: 2947-3191
Range on HMM: 32-278/290.0
KDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPP
..|.... |  |||| .|  ||.|||.|... ...||||||||.| | ... .|||.|||.|. . ||||||||...| |||. .. | |..||. ||| 
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

PDKRVVVHGQIRIQLQEELSLT-DYTIRTFSLQHKvsSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISC
  .. . .|.....|.||  .. |..|||. ....  ...|...|.|.|.||| |||. ...||..|..|.. . ... |.||||||||||||| |.|  
egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

QIQQILDR---KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
  ... ..   ..||... |...| .|  .|||. || ... |..|...
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN3_pd Subfamily PTPN3 2948-3188 2.6e-72 238.1 In-house 34-273 (280) alignment 
Range on Protein: 2948-3188
Range on HMM: 34-273/280.0
DATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYID----GYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLY
.|.. |.|. |||| .|..||. ||||.| ..    |||||||..    . .  | |||.|||....  |||.|.||||....||||.| |.||.||| |
saarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPPPDKRvVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITI
|| .... . .|........| . . | .| . |..| ...||.| |  ...||| |||.... .|.|...|..    .  |||||||||.|||| .|..
WPetede.leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

SCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
   .. |  .. . . . |. || .|  .|||..|| |. .|.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN13_pd Subfamily PTPN13 2948-3191 6.4e-71 233.8 In-house 30-270 (273) alignment 
Range on Protein: 2948-3191
Range on HMM: 30-270/273.0
DATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsdYINANYIDGY--KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
. ... .|  |||| |.  ||..|||| .. .     ||||..|     |.|  |||.|||.|... |||.|.||||.| ..|.|.  |||..||| |||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

PP-DKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPkNAGPVVVHCSAGVGRTGTFITIS
   .|...|.......| .   | ....|.. .... |.. | . . .|..||| ||| ... ||.|. .|.| .  .|||.|||||||.||.||.||| 
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

CQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
  .. |   | .|. . |...| .|  .|||. ||||.. |.|| |.
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2948-3201 1.4e-60 199.6 In-house 26-277 (283) alignment 
Range on Protein: 2948-3201
Range on HMM: 26-277/283.0
DATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYID---GYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
| .   .|  |||. .| ..|  ||.|  ...    ||||| .|     ||... ||..|.|. . .||||.|....|  ..||||.| |  ||||  ||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSS-DERTIKQYHFTSWPDFGVPEHPTTLLRF--IHKVQRENPKnaGPVVVHCSAGVGRTGTFI
|   .  . .|.  . |..| .   ..|. . |... |. ..  .  | .  | ..|      .|..|  .   |.|..|  ||.|||||.|.|||..||
P..krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskk..gPivvhCstgiGrtavfi

TISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSARE
..|. ....|    .|... |. || .|  .|||  || ..|.. ||   ||.|.. | .
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd
0049772 (Phosphotyrosine protein) phosphatases II 2948-3195 9.3e-46 152.3 In-house 39-285 (314) alignment 
Range on Protein: 2948-3195
Range on HMM: 39-285/314.0
DATQHPDNAIKNRYANISAYDhSRVKLtEDPNVPGSDYINANYIDGYkkeNAYIASQGPVPHSIVDF----------WRMI--WEQKTETVVM-------
 . ... |  |||| .|  .| .||.|    .| |||||||.|.||.   ...||.||| .. .|||          |||.  ..... ..||       
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTNLEEKGrikchlywpppdkrvvV----------HgqiriqlqeelsltD-------YtirtfslqhkvssdERTIKQYHFTSWP
              |..| ..|                           .              .       .              ||.. .|. . .|
delsrLdaAlgKtpllildgng................neptaadlellk..............eelydpelf..............erlgikylripvp

DFGVPeHPTTLLRFIHKVQREnpKNAGPVVVHCSAGVGRTGTFITISCqiqqILDRKCLDIYNFVQSMRYRRC-----FMVQTEAQYIFIHDALLEYLEC
|...|  .  ...|.. ...   .. |||.|||.||.||||||... .    .. .  ...   .. .| .|       ....  ||.||..||||||. 
Dgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaay....lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkf

GET
 ..
lkk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2948-3190 1.4e-43 143.6 In-house 47-289 (305) alignment 
Range on Protein: 2948-3190
Range on HMM: 47-289/305.0
DATQHPDNA-IKNRYANISAYDHSRVKLTEDPnvpGSDYINANYIDGY-KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
.| | .| |  ||||... . |.| ||| . .    |||| |||.      |. .|..|||. ..| .|| |. ..| | .||| .  | |..||  |||
nanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

PP--DKRVVVHGQIRIQLQEELSL-TDYTIRTFSLQHKVSSDE-RTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRenpkNAGPVVVHCSAGVGRTGTFI
    .|. .  | .  ..     .  |  |.   |.   | |.  .... ..| ||| |||    | | ..  ..        |.|||||||.||||| .
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtiv

TISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.|   ...| .  .|  . ..|...| .|.| .|.. ||.|||  .|.|.
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2949-3193 4.3e-87 286.5 In-house 3-245 (250) alignment 
Range on Protein: 2949-3193
Range on HMM: 3-245/250.0
ATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIkCHLYWPPPD
 ...|.|  |||||.| |.|.||| | ..     |||||| ...||....|.||.|||....|.|||||..|.|..|.||||||.|...  .| |||   
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

krVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQI
     .|.....| ..   .|||.|.. | ..  .|||...|.||..||| ||||. |. | ...|||..... ...||.|.|||||||.|.||.|.. .
..aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

QQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
...   | .|...... .|  |  .|....||.|.. ..|..|.. 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0042113 (Phosphotyrosine protein) phosphatases II 2949-3190 1.2e-84 278.8 In-house 3-243 (245) alignment 
Range on Protein: 2949-3190
Range on HMM: 3-243/245.0
ATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpd
 ...| |  |||| .| .|||.||||..|.. ..||||||.|.|||.  . .||.||| |... |||||.||.. .|.||||..||.||.||. |||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

KRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENP-KNAGPVVVHCSAGVGRTGTFITISCQI
. ....|.....| .| .| |||.||...... .. .|.. .||...|||.|||... .||.|.. |..    .. |||.||||||||||||||..   .
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.|.  ........ |. .| .|. .|||. ||.|...||||.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2949-3189 3.4e-42 139.0 In-house 31-268 (281) alignment 
Range on Protein: 2949-3189
Range on HMM: 31-268/281.0
ATQHPDNAIKNRYANISAYDHSRVKLTE-DPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPP
. ..| |  ||||.|| . | |||.|    ||   .||| ||||     .  || .|||   .  |||||||...| ..||| .. |  | ||  |.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

DKRVVVHGQIRIQlqEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRenpkNAGPVVVHCSAGVGRTGTFITISCQI
 . ..   .. ..   | |  . .. |  |.     . | | .. .  |||. |||    .|. ..|..      . | |.||||||||.||....   .
ahcclqfdklsvs..yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcsagvgrsgtlmaveial

QQILDRKCL-DIYNFVQSMRY-RRCFMVQTEAQYIFIHDALLEY
| |  .  | || . |  .|   |.  |||  ||..|   ||..
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0037934 (Phosphotyrosine protein) phosphatases II 2950-3190 1.6e-77 255.6 In-house 5-242 (243) alignment 
Range on Protein: 2950-3190
Range on HMM: 5-242/243.0
TQHPDNAIKNRYANISAYDHSRVKLtedpnvPGSDYINANYIDGYKKenaYIASQGPVPHSIVD----FWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
 ..| |  |||| .| .||||||||      .||||||||.|.....   .||.||| |... |    ||||.||......||||.|.|.||.||. |||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

ppDKRvvVHGQIRIQLQEELSLTDYTIRTFSLQHKV-SSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRE--------NPKNAGPVVVHCSAGVGR
  ..   ..|.....| .| .| |||.||..|...  .  .|.. .||...|||.|||..|. ||.|...|.          . .. |||.|||||||||
..gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTFITISCQIQQIldrkCLDIYNFVQSMRYRRCF-MVQTEAQYIFIHDALLEYL
|||.|..   ....    ..|... |. .| .|.. .|||. ||.|...||||.|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2950-3203 1.7e-76 252.4 In-house 20-268 (284) alignment 
Range on Protein: 2950-3203
Range on HMM: 20-268/284.0
TQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTnleekgRIKCHLYWPppDK
.  ..|  |||. .| |.|...|||     . .|||||| .| ||.... |||.||| . .. ||||||||... |.|.||      . ||  |||   |
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp..lk

RVVVHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA--GPVVVHCSAGVGRTGTFITISCQ
 |. ... .....      .|..| . | .     | |.|.|.||  ||| |||..|. |.|...||.  . |.    ..||||||||||||..|.. . 
ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

IQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVK
.... . | .|.||||. .| .|  .||  .|| ||. ||||    | ..|.  .. 
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2950-3195 2.1e-38 126.9 In-house 30-274 (285) alignment 
Range on Protein: 2950-3195
Range on HMM: 30-274/285.0
TQHPDNAIKNRYANISAYDHSRVKLTEDpnvpGSDYINANYIDGY-KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPD
| .  |   ||||.. . . .|| | .       ||| |...    | ...||..|||.| .. |||.||...|   |.||  | | |  || ||.|   
tayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

KRVVVHGQIRIQLQE----ELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAgPVVVHCSAGVGRTGTFITIS
  ||  |.  | | |     .. | .   |       ||.   ... .   |||   ||    .. . . |.. |||.  |..|||||||||| ||. | 
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgid

CQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLeCGET
    .|..   ... . |. ||  |   ||.  |..|..  |.||.  || 
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyf.igeg
subfamily_ptpA1_pd Subfamily ptpA1 2951-3148 8e-42 138.4 In-house 43-254 (418) alignment 
Range on Protein: 2951-3148
Range on HMM: 43-254/418.0
QHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKeNAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPP--D
..  |. ||||.||   .|.||.| .  .  ||||||||||||    . .|..|||.| .| |||||.||..   .|||.   |. ||||  |||     
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

-------KRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQ-REN---P--KNAGPVVVHCSAGVG
       .   | |   ..| | .   .  | |  ..  .  . | | ||..  |||. .|.|   . ...| .  |.|   |      |..||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTFITISCQIQ
||||| |    ..
rtgtfctavimmk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2951-3207 2.3e-31 103.6 In-house 48-297 (301) alignment 
Range on Protein: 2951-3207
Range on HMM: 48-297/301.0
QHPDNaiKNRYANISAYDHSRVKLTEDPN-VPgsdyINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDK
  |..  |.|| ..    .. |.. .| . ||    | ||.|.   . . .||.|||.. .  ||| |.   . |..|||..  ||   ||. | |   .
ylpkd..khryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

RVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSD---ERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQ
. .  |. .|..... .. .  |   .|. . |..    ||.  | ...|.| |||.  . |  ... |.    |   |.|||||||.||. .||.  . 
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteyl

IQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLeYLECGETEVSAREVKEQFR
 ....  . ... . .. .| .|   |||. |  ..    . |    | ..  .  .||..
areveadptieltealkhlrehrwngvqtnsqlywmtlGtv.yrlikeygfdmkiyeeqla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2952-3188 3e-68 224.6 In-house 5-239 (239) alignment 
Range on Protein: 2952-3188
Range on HMM: 5-239/239.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKR
.  |  ||||||| .|||||| | .  | | ||||||.|.  |    .||||.|| |  |  |||||.|...   .|||| | |  . ||| |||    .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

vvvHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQI
   . ..|. |..   ..|| |||| . .   ..|| . ||||| ||| |||.. |..| . .|. ...   | | |.||||||||||.|. | . ..| 
...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
  .| .||.|.|...|  | .||||  ||.||| |.||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2952-3191 2.9e-62 205.1 In-house 35-278 (287) alignment 
Range on Protein: 2952-3191
Range on HMM: 35-278/287.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRV
.  .. |||||..  .|..|| |.....  |||||||||. .|....|.||.|||.. .. ||||...|... .|...|   |..| ||. ||| ... .
elaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

VVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKV-----QRENPKNAGPVVVHCSAGVGRTGTFITISCQ
 | |   . |. .    .|..|.. | .  . . | .||... |||| ...     |.||. .|      . . ...||.|||...|.||.|.....   
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

IQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
... .|   .|. . |  .| .|  .||.  |. .. .||  | .
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_CG7180_pd Subfamily CG7180 2952-3194 5.6e-53 174.5 In-house 39-294 (296) alignment 
Range on Protein: 2952-3194
Range on HMM: 39-294/296.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRiKCHLYWPPPDkrV
. .|  |||. ..  ||. || |..      |||||| |.|.. |...||  ..|. ... .|||.........||.||.  .  . ... |||.     
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..k

VVHGQIRIQLQEELSLTDYTIRTFSLQHK----------VSSDERTIKQYHFTSWPD-FGVPEHPTTLLRFIHKVQRENPKN-----AGPVVVHCSAGVG
  .|.| ... || .... .|||| |..|          |. ..|..|....| |.    ||   ..|. ....|.    |.      |||||..| |..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
|.| ...|   ....   ...|....|. .|  |  .|..  .| .| | |||.. |. 
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2952-3191 1.7e-43 143.5 In-house 45-288 (305) alignment 
Range on Protein: 2952-3191
Range on HMM: 45-288/305.0
HPDNAIKNRYANISAYDHSRVKLteDPNVPgSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRV
. ..| |||| ..   |. ||||  ..  |  .|| |||.    . . .| .| |. ..  ||| | ...| |.. || || |||  ||. |..  || |
eaqeagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

VVH--GQIRIQLQEELSLT-------DYTIRT-FSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFI
.    .. .|... | | |       . ...    .     .. | ...||.  ||| |||   ...| ...| .       ||.|||||||.||||. .
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvv

TISCQIQQILDRKCLD-IYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 .   ..|.|  . ..     .| .| .|   .||.|||.|.|. .|.|..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2952-3200 7.7e-38 124.8 In-house 49-299 (310) alignment 
Range on Protein: 2952-3200
Range on HMM: 49-299/310.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDkRV
. ..  ||||...   | |||||. |      ||| |||.      ...| ||||. |.|.||||||.....|....| .  |.|| ||  |||      
ykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.vt

VVHGQIRIQLQEELSlTDYTIRTFS---LQHKVSSDERT-------IKQYHFTSWPDFGVPEHPT--TLLRFIHKVQRenpknaGPVVVHCSAGVGRTGT
  .| ||.    | |  .. |  ..   .  .|  ||.        ..  ..  ||| |||.        |.. .|.       ||.|||||||..|...
etygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh......gpcvvhcsagkdrlyv

FITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYlECGETEVSAR
 ...  .|...   . .|. . .  .. .|   .||| ||..|.   . .   |||||. .
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif.argetevaek
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2952-3114 5.1e-34 112.5 In-house 30-192 (297) alignment 
Range on Protein: 2952-3114
Range on HMM: 30-192/297.0
HPDNAIKNRYANISAYDHSRVKLTEdpNVPGSDYINANYIDGYKK--ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDK
 .    |||| .| |.| .||||     ....|||||.|.   ..  .  || .|||.  .. |||....||   ..||...|.| || ||  |||  ..
rnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

RVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHK
     |.. ..   . |    ..    ||    |..| ..   | |||| |||     | ||  .
erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2953-3190 9.4e-52 170.9 In-house 39-277 (307) alignment 
Range on Protein: 2953-3190
Range on HMM: 39-277/307.0
PDNAIKNRYANISAYDHSRVKLTEDPNvpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVV
  |. |||| .. . |..|. .. |     |||| |||.    | . .|..|||   .. .|| |. ..| |.|.|| .. | ..|||. |||  . .  
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

VHGQI--RIQL----QEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQ
|.|.    | .     ..|.  .  |   .|. . ... |||... .. ||| |||.   | . ... |.     .  ||||||||||||.|| ..||  
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislv

IQQIL-DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
 ....    | |. ..|. .| .| . .||||||...|  ||||.
qdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2953-3191 3.6e-45 149.1 In-house 31-260 (267) alignment 
Range on Protein: 2953-3191
Range on HMM: 31-260/267.0
PDNAIKNRYANISAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEkGRIkcHLYWPPPDKRVV
 .|. .||. .   ||..|| | .  .     |||| |..|||..||.|. |.|.  .| ||. .| .||  ..|.||.  . . |  .|.|||   .  
eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dni..rlfwPPkmgqak

VHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDErTIKQYHFTSWpDFGVPEHP--TTLLRFIHKVQRENPknAGPVVVHCSAGVGRTGTFITISCQIQQI
 . .. ..   |    || | |. |. |  |    .  |..  | .  . ..|    |.  . | | ||     |.||.||.||||.|||..|  |....
kyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkw.nintnnkpylkplfgilaknqleng..nrPlvvacsdGvGrsGtflvidsqlera

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
     .||..|.. .| .|  .|.|  .||.||. | || |
ktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_egg_pd Subfamily egg 2953-3191 1.7e-29 97.4 In-house 38-271 (307) alignment 
Range on Protein: 2953-3191
Range on HMM: 38-271/307.0
PDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKgrIKCHLYWPP--PDKR
 .|  | |   .   | |||||         |.| ||...|    | .| .| |.  .  |||||..... . .||||   |    .|. |||    |  
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

VVVHGQIRIQLQEELSLTDYTIRTFSLQHkVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRFIHkvqrenpKNAGPVVVHCSAGVGRTGTFITISCQIQQ
|.| | .||.  .  | .|   |   |.  | .| |    ..    .   .    |  .|| .        . . ||||..  || ...|...|   . .
vtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqgdvnnssdvysplrvlrklr.......nlskpvvvqdilGvskaatlvaieialls

ILDRKC--LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
.|        . . |. .| || . |..  .|.|..  .| .. 
llrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2954-3188 1.5e-71 235.4 In-house 2-237 (237) alignment 
Range on Protein: 2954-3188
Range on HMM: 2-237/237.0
DNAIKNRYANISAYDHSRVKLTEDPNvpGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRvV
.| |||||.|| ||||||| |    .  |||||||.|..|.    . |||.|||.  |  |||.|.|..|   .|||| | |. ..||| |||  |.   
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp.a

VHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDE-RTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITISCQIQQ
 .|.. . |. .  ..|||.|.. |.....  | | |.||.|||||| |||.. ..|||| ...  ..|.  ..|| ..|||||||||| |. | . ..|
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

ILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
  ..| .||||.|.|.   | ...||. ||.|||...||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2954-3188 3.1e-68 224.5 In-house 6-238 (239) alignment 
Range on Protein: 2954-3188
Range on HMM: 6-238/239.0
DNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRvv
 |  ||||||| .|||||| | .  | | ||||||.|.  |    .||||.|| |  |  |||||.|...   .|||| | |  . ||| |||    .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..

vHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILD
 . ..|. |..   ..|| |||| . .   ..|| . ||||| ||| |||.. |..| . .|. ...   | | |.||||||||||.|. | . ..|   
.ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
.| .||.|.|...|  | .||||  ||.||| |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2954-3189 1.7e-51 169.6 In-house 53-282 (290) alignment 
Range on Protein: 2954-3189
Range on HMM: 53-282/290.0
DN--AIKNRYANISAYDHSRVKLTEDpnVPGsDYINANYIDGYKkeNAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRV
 |    |||| ..   | .|| | .    .| ||. |||..| |    .| .||..  ...|.|||. ..|. ..||| .| |.|. ||. |.|  . .|
kntefkknrykdvvcndktrvilkdG..ydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VVHGQIRIQLQEELSLTDYT-IRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQIQQI
.  |.| .   || .  . .  .|.|...| |  |  .| ..  ||||  |.    .||| .. ..    | .||||||||||.||||||..|   .| .
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqil

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
|| | ||. . |...|  |   || . ||. . ..||..
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2954-3029 2e-07 24.9 In-house 36-116 (347) alignment 
Range on Protein: 2954-3029
Range on HMM: 36-116/347.0
DNAIKNRYANISAYDHSRVKLTED-----PNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVML
 .  |||  .    | .|| |. .     .  .   |||| .|   . .. || .| |.|... |||.|.   |   || .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
Y_phosphatase Protein-tyrosine phosphatase 2955-3188 1.3e-86 285.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 2955-3188
Range on HMM: 1-235/235.0
NAIKNRYANISAYDHSRVKLtedPNVPG-SDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVV
|  |||| .| .||..||||    . .| ||||||||..|||.....||.|||....| |||||.|..|....||||.|||||| ||. |||  ... . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGQIRIQLQ-EEL-SLTDYTIRTFSLQHKVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQI
.|.|...|. .|    ..||.|...|..| ... .|..||.|.|.||| ||||.|. ||..|.||.... .. |||||||||||||||||..... ..|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
 .....|....|...| .|. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 2955-3188 1.3e-86 285.2 In-house 1-235 (235) alignment 
Range on Protein: 2955-3188
Range on HMM: 1-235/235.0
NAIKNRYANISAYDHSRVKLtedPNVPG-SDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVV
|  |||| .| .||..||||    . .| ||||||||..|||.....||.|||....| |||||.|..|....||||.|||||| ||. |||  ... . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGQIRIQLQ-EEL-SLTDYTIRTFSLQHKVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQI
.|.|...|. .|    ..||.|...|..| ... .|..||.|.|.||| ||||.|. ||..|.||.... .. |||||||||||||||||..... ..|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
 .....|....|...| .|. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN23_pd Subfamily PTPN23 2955-3190 7.2e-63 207.1 In-house 43-280 (288) alignment 
Range on Protein: 2955-3190
Range on HMM: 43-280/288.0
NAIKNRYANISAYDHSRVKLTedpnVPGSDYINANYIDGYKKE-NAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVV
.. |||. .|  |||.||||         ||||| .. .       .||.|.| . .. |||.|..|||....|||.. ||.|. |.. |||    . |.
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

HGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQR----ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQ
.|.... |... ..  .  |...|... ..  ....  ..||||..|||. | |||.|...|.     .. |   |.||||||||||||.|  . . ...
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

ILDRKC-LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.  ..  ||| . |. .|  | ||||...|. |  .| ||. 
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0041856 (Phosphotyrosine protein) phosphatases II 2955-3196 3.4e-54 178.5 In-house 1-177 (182) alignment 
Range on Protein: 2955-3196
Range on HMM: 1-177/182.0
NAIKNRYANISAYDHSRvkltedpnvpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTnleekgrikCHLYWPppdkrvvvh
|  |||| .|  |||||          ..||||||...|. . . .|| ||| .... ||.||..|..  |.|.||         ..||||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gqiriqlqeelsltdytirtfslqhkvSSDERTIKQYHFTSWPDFGVPEhPTTLLRFIHKVQRenpkNAGPVVVHCSAGVGRTGTFITISCQIQQildrk
                           .  ||.. ||....|||.|||. . .||.||..|..    . |||.||||||||||||.. .   ...     
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

CLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETE
 ..... |. .| ||. ||.|. ||.|...||||.|....|.
gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2955-3082 4.2e-23 76.6 In-house 47-187 (350) alignment 
Range on Protein: 2955-3082
Range on HMM: 47-187/350.0
NAIKNRYANISAYDHSRVKLTEDP--------NVPGSDYINANYIDGY----KKENA--YIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKC
   |||| ||  |.|||||| . .         . ..|||||||.       . .    ||| |.|.|  . ||...| . | . ...||.. | .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HLYWPppdkRVVVHG-QIRIQ--LQEELSLTDYTIRTFSLQHKVS
. ||.    .  ... .....   ..  .  | ..... .... |
yrYWq....egsydditvklaskwenimgindsslysadvkkeas
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2955-3039 1.2e-12 42.0 In-house 34-117 (332) alignment 
Range on Protein: 2955-3039
Range on HMM: 34-117/332.0
NAIKNRYANISAYDHSRVKLTedPNVPGSDYINANYIDGYKKENAYIASQGPVP-HSIVDFWRMIWEQKTETVVMLTNLEEKGRIK
|   ||   . ..|||||.|.  |.    |. ||...||| |..||| .| |.  |.   ||||. |.|   .... ...|| . |
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2955-3036 1.2e-06 21.5 In-house 27-81 (169) alignment 
Range on Protein: 2955-3036
Range on HMM: 27-81/169.0
NAIKNRYANISAYDHSRVKLTEDPNVPGSDYINAnyidgykkenayiasqgpvphsivdfwRMIWEQKTETVVMLTNLEEKG
|  ||| |   |  | ||||    .  |||||||                           |||||  .  .|.| . ..| 
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2955-3036 1.5e-06 21.1 In-house 26-80 (169) alignment 
Range on Protein: 2955-3036
Range on HMM: 26-80/169.0
NAIKNRYANISAYDHSRVKLTEDPNVPGSDYINAnyidgykkenayiasqgpvphsivdfwRMIWEQKTETVVMLTNLEEKG
|  ||| |   |  | ||||    .  |||||||                           |||||  .  .|.| . ..| 
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn
subfamily_CG42327_pd Subfamily CG42327 2956-3116 3e-28 93.4 In-house 29-191 (319) alignment 
Range on Protein: 2956-3116
Range on HMM: 29-191/319.0
AIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDK--RVV
  |.|..|.    ..|| | . .. . . |..|.|. ||.. .| |||.| .   |  ||||..|||.. ..| ||.| |.|  .|  |.|. .      
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

VHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFtSWPDFGVPEHPTTLLRFIHKVQ
..|.|.. |..  .   | | |. |..   .  | .  | .  |.. .|| ....|.  . .|.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2956-3045 3.7e-15 50.1 In-house 49-154 (349) alignment 
Range on Protein: 2956-3045
Range on HMM: 49-154/349.0
AIKNRYANISAYDHSRVKLTEDPNVPG--------------SDYINANYID--GYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIK
  |||| .|  |.|||||| . .. .                |||||||.    .. |. ||| | |.| .. ||...|  .. . |. |.. .|..  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHLYWP
|. || 
cdiywq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2959-3194 5.6e-30 99.1 In-house 47-280 (312) alignment 
Range on Protein: 2959-3194
Range on HMM: 47-280/312.0
NRYANISAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPP-------PDKRV
||| ||  .|  |  |. | |     || ||..    | . ....|||.  ... ||..     . ....|. . | |  ||  |           |.||
nrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

VVHGQIRIQLQEElSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQIQQIL
       |..    |    | | . .  | . .|  ...| ..|||| |.|.   | ||..  |.    |.  ||. |||||||||||.. |   |  . 
yteycteieiggk.skdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmiaalr

DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
  .  .. .    .|  |.  |.. .||..   ..||.| .  
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2959-3206 4e-21 70.4 In-house 23-266 (290) alignment 
Range on Protein: 2959-3206
Range on HMM: 23-266/290.0
NRYaNISAYDHSRVKLTEDPNVPGSDYINANYIDgYKKENAYIASQGPVPHS-------IVDFWRMIWEQKTETVVMLTNLEEKGRI----KCHLYWPPP
.|. ...   ..|| | .  .   .||| ||..  . .  . |..| |  .        | .|| |. . | . |||| . ||| .      |  | |  
qRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

DKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKvSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQI
    .  . . .. ..     |  .|.  ...     | |.. . . .| .  |.|.. |||  |.||.    ..  ||.|||  |. |  .. .|    
vgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

QQIL-DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLeylecgeteVSAREVKEQF
| |   .. . . . ....| .|  ..... .. |.  ...         . | ||..||
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqf
0044763 (Phosphotyrosine protein) phosphatases II 2967-3193 1.4e-40 134.1 In-house 2-174 (178) alignment 
Range on Protein: 2967-3193
Range on HMM: 2-174/178.0
YDHSRVKLTEDPNVPGSDYINANYIDGYkkenAYIASQGPvphsiVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKrvvvhgqiriqlqeels
.|..||.|.. .....||||||..|...     |..|..|     .|......|..  ..|.||.  | |..||. |||                     
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

ltdytirtfslqhkvssdertiKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQildrkCLDIYNFVQSMR
                       ||... .||.|||. .  .|.|.. ...  ... |||.|||||||||.||.. .   ...      |.... .. .|
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

YRRCfMVQTEAQYIFIHDALLEYLECG
 ||. .|... |. ....  |..|. .
erRp.ivpnpgqlrqLyefelrllkes
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2968-3048 1.9e-06 22.2 In-house 6-73 (130) alignment 
Range on Protein: 2968-3048
Range on HMM: 6-73/130.0
DHSRVKltedpnvpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRikchlYWPPPD
. ||..        | .||||...    . . |. .| |.  . .|||.|. |.  . .|.|  .||.       |||  .
evsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdse
0046846 (Phosphotyrosine protein) phosphatases II 2977-3191 1.1e-45 150.8 In-house 6-174 (176) alignment 
Range on Protein: 2977-3191
Range on HMM: 6-174/176.0
DPNVPGSDYINANYIDGYKkenaYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVvhgqiriqlqeelsltdytirtfs
.   ...||||||.|.|..    .|| |||.|... ||..|..|.. ..||.||.. |.||.||. |||   |  .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lqhkvssdertikQYHFTSWPDFGVPEHpTTLLRFIHKVQRENPKNaGPVVVHCSAGVGRTGTFITIScqiqQILDRKCLDIYNFVQSMRYRRC-FMVQT
             ||... |||.|||.. . ||...  ...   .. |||.||||||.|||||.. .      .  .|.|.... .. .| .|. ..|||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

EAQYIFIHDALLEYLE
..|| |.....|..|.
peQyrflyefellllk
0051429 (Phosphotyrosine protein) phosphatases II 2980-3213 1.9e-56 186.9 In-house 1-247 (272) alignment 
Range on Protein: 2980-3213
Range on HMM: 1-247/272.0
VPGSDYINANYIDGYKK---ENAYIASQGPVPHSIVDFWRMiWEQKTETVVMLTNLEEKGRIKCHLYWP----------PPDKRVVVHGQIRIQLQEELS
.| |.||||....|| .   ......|.|| |... ||||. .|..  |.|.|...||.|| ||..|||          . .   . .|..|. |..|  
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTDYTIRTFSLQHK-VSSDERTIKQYHFTSWPDFGVPEHPttLLRFIHKVQRenpknAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLD--------
|.||..|.. | ..   .. |.. ..|.|.|||.|||...  ||.... ...      |||.||||||..||||.. .   .... .   .|        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYlECGETEVSAREVKEQFRLLNEVF
....|. .| .|  .||||.||.|...||||.  .. ..|.|. ..  .. ..| .
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaideey
0043147 (Phosphotyrosine protein) phosphatases II 2981-3183 2.9e-45 149.4 In-house 3-154 (172) alignment 
Range on Protein: 2981-3183
Range on HMM: 3-154/172.0
PGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLeekgrikchlywpppdkrvvvhgqiriqlqeelsltdytirtfslQHK
.|||||||.|.|.| . . .|| ||| .. . |||||..|..  ..|.||.|                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

VSSDERTIKQYHFTSWPDFGVPeHPTTLLRFIHKVQR-ENPKNAGPVVVHCSAGVGRTGTFITISCQIqqildrKCLDIYNFVQSMRYRRCFMVQTEAQY
 .  ||.. ||....|||.||| ..  ||.|.. ...  . .. |||.||||||||||||.. .   .      ..|.... |. .| .|. .||.. ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIH
.|..
rfly
0036282 (Phosphotyrosine protein) phosphatases II 2982-3184 1.6e-49 163.3 In-house 1-164 (174) alignment 
Range on Protein: 2982-3184
Range on HMM: 1-164/174.0
GSDYINANYIDGYKKENAYIASQGPVPhsivdFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdkrvvvhgqiriqlqeelsltdytirtfslqhKV
|||||||...|..   . .||.||| .     ||.|..|.. .|||||....|.|. ||. |||                                  . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

SSDERTIKQYHFTSWPDFGVPEHPTtLLRFIHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQIQQILdRKCLDIYNFVQSMRYRRCFMVQTEAQYI
.. ||.. ||... |||.|||. .. ||.|.  |..   . . |||.||||||||||||.. .   ....|  .  |....|...|. |. ||||. ||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FIHD
|...
flyy
0051082 (Phosphotyrosine protein) phosphatases II 2982-3187 2.8e-38 126.2 In-house 2-150 (151) alignment 
Range on Protein: 2982-3187
Range on HMM: 2-150/151.0
GSDYINANYIDGYkkenaYIASQGPVPhsivDFWRMIWEQKTETVVMLTNLEEKGriKCHLYWPPPDkrvvvhgqiriqlqeelsltdytirtfslqhkv
 |||||..|..|.     ...|.|| .    ||.....|..  |.|.|...|| |  .|. |.|  .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ssdeRTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRenpKNAGPVVVHCSAGVGRTGTFITISCQIQQildrkcLDIYNFVQSMRYRRCFMVQTEAQYIF
    ..........|||.|.|... ..|.|......   |. |||.||||||.|||||.. . . ...      ....  .. .| .|. .||.. |..|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IHDALL
.. |||
qlfall
0049260 (Phosphotyrosine protein) phosphatases II 2990-3184 2.4e-42 139.5 In-house 1-144 (152) alignment 
Range on Protein: 2990-3184
Range on HMM: 1-144/152.0
YIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWpppdkrvvvhgqiriqlqeelsltdytirtfslqhkvssdertik
.||||.. ...|| ||| |... |||||..|..  |.||||.|.|.|..||. |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIqqildrKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHD
||... |||.|||...  || ... ... . .. |||.||||||||||||.. .   .      . ......|. .| .|  .|... |..|...
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2992-3080 1.3e-12 41.8 In-house 230-314 (440) alignment 
Range on Protein: 2992-3080
Range on HMM: 230-314/440.0
DGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKgriKCHLYWPPpDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK
.|| | ||.||.| |.  ...||||.. . .  |..|| .|..|    | .|||  . | |  | . .  .    .    .||. |..|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv.ntrsvtfgpftvghkgsenmnrvkvrtlelkyk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2995-3183 1.2e-21 71.8 In-house 2-197 (199) alignment 
Range on Protein: 2995-3183
Range on HMM: 2-197/199.0
KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSS--DERTIKQYH
| .  |||.| |. ... |||.|.||  .  .||. . . .      .|||  .  .  .| . .  .   .  |||| .. |  ....    | | .| 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDFGVPEHPtTLLRFIH---KVQR--ENPkNAGPVVVHCSAGVGRTGTFITISCQIQQILDRK--CLDIYNFVQSMRYRRCFMVQTEAQYIFIH
|||| .   |.    .. |.    .| .  |.  .  ||.|||| | | || |...   ..   . |   .|...  . .|  || .. .  .| ||.
ftswkekttpnva.lfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2996-3205 1.2e-21 71.9 In-house 33-237 (255) alignment 
Range on Protein: 2996-3205
Range on HMM: 33-237/255.0
KENAYIAsqgpvphSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEelSLTDYTIRTFSLQHKVS--SDERTIKQYHF
. | |.        ..  |...|  .|||.||||....|.|. ||. |.|       .  .. .   .  | .|  .||  .  ...     .|.| |..
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysy

TSWPDFGVPEHPTTLLrFIHKVQRENpKnagPVVVHCSAGVGRTGTFITISCQIQQI---LD---RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALL
. |..   || .  .| .| || |.  |   .||||||.|.||. .|. .    |..   ||      ||  .... .| .|   ..|  |  |    .|
kGWieknaPelareil.nilkvvrds.k...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

EYL-ECGETEVSAREVKEQ
...   || |    |... 
dlvfpkgeleakyqeirks
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2997-3183 1.6e-21 71.4 In-house 3-196 (198) alignment 
Range on Protein: 2997-3183
Range on HMM: 3-196/198.0
ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSS--DERTIKQYHFT
.  |||.| |. ... |||.|.||  .  .||. . . .      .|||  .  .  .| . .  .   .  |||| .. |  ....    | | .| ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDFGVPEHPtTLLRFIH---KVQR--ENPkNAGPVVVHCSAGVGRTGTFITISCQIQQILDRK--CLDIYNFVQSMRYRRCFMVQTEAQYIFIH
|| .   |.    .. |.    .| .  |.  .  ||.|||| | | || |...   ..   . |   .|...  . .|  || .. .  .| ||.
swkekttpnva.lfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_hpo-7_pd Subfamily hpo-7 2998-3189 8.7e-18 59.2 In-house 38-226 (263) alignment 
Range on Protein: 2998-3189
Range on HMM: 38-226/263.0
NAYIAsqgpVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSltDYTIRTFSLQHKVS--SDERTIKQYHFTS
| |.     .   |  |...|  .|||.||||.. .|.|. ||  |.|       .  .. .   .  |  |  ..|  |   ..     .|.|.| .. 
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykg

WPDFGVPEHPTTLLRfIHKVQRENpKnagPVVVHCSAGVGRTGTFITISCQIQQI---LD---RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
|..   || .   |. | || |.  |   ..|||||.|.||.  |  .    |..   ||      ||  .... .| .|   ..|  |  |    .|..
Wiekndpelareiln.ilkvarns.k...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 3006-3182 1.8e-20 67.6 In-house 99-280 (302) alignment 
Range on Protein: 3006-3182
Range on HMM: 99-280/302.0
PVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRI---QLQEELS-LTD------YTIRTFSLqHKVSSDERTIKQYHFTS
|   ..  .| .| . ..  || |... |..  ||  |.    . ..  |.  .   .....|. .||      ||.      .| .  ..|..  .|..
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveikne.kkkkkvkktvdilafsa

WPDFGVPEHPTTLLRFIHKVqrENPKNAgpVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFI
||| | |... | |  ..    |  |..  |.||||||||||||...|   ||  . .|  |. . |. .|  |   ||.| | |..
wpdhGapkeaytaldilkfc..esykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 3011-3210 2e-07 23.9 In-house 131-329 (346) alignment 
Range on Protein: 3011-3210
Range on HMM: 131-329/346.0
IVDFWRMIWEQKTETVVMLTNlEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
. ||| ||.... . | ..   ..| .      .   .      |.. |. .      |    |  .  .  ||    . .| . |  .  | .   ...
vedfwymiyqeqihlvylmvp.ddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik

FIHKVQRENP-KNAGpVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLL
.||.   |.  .||| | |    | ||. .||     |.|. .    .|.. ..... .|   |.. |||  |.  ...|.       .|   |.  |..
mihqflsekqvqnag.vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdinrfi

N
.
d
0048076 (Phosphotyrosine protein) phosphatases II 3064-3189 5.2e-27 89.7 In-house 22-142 (145) alignment 
Range on Protein: 3064-3189
Range on HMM: 22-142/145.0
ELSLTDYTIRT-FSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNaGPVVVHCSAGVGRTGTFITISCQIQqildrKCLDIYNFV
   | |. |.| ..| .  .  ||.. ||....|||.|||. . .||.|.. ...  ... |||.||||||||||||.. . . ..     . ..... .
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleeal

QSMRYRRCFMVQTEAQYIFIHDALLEY
. .| .| ..|... |..|.....||.
elvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 3066-3184 2.1e-25 84.6 In-house 27-139 (144) alignment 
Range on Protein: 3066-3184
Range on HMM: 27-139/144.0
SLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNaGPVVVHCSAGVGRTGTFITISCQIqqildRKCLDIYNFVQSM
.|  .|. ... ..   . ||.. ||....|||.|||.... ||.|.. ...  ... |||.||||||||||||....   .     .. |.... .. .
klgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalv

RYRRCFMVQTEAQYIFIHD
| ||...|... |..|...
rsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 3083-3190 2e-06 21.6 In-house 224-338 (347) alignment 
Range on Protein: 3083-3190
Range on HMM: 224-338/347.0
SDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK-------NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQT
|.    | |  |.||    |.    .| ..    .|          .  |||| |  |. |. | .  |  |.|.|| |  |  .. . || .|. .   
seatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftm

EAQYIFIHDALLEYL
   | .   | | ||
sifytyairaalfyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3084-3227 1.7e-28 94.2 In-house 87-230 (440) alignment 
Range on Protein: 3084-3227
Range on HMM: 87-230/440.0
DERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFI
. ||.||||. .||| |||.    .|..|. |.  . |   ||..||||||.||||  |.. . ...      .||..|..|||  |  ||||  || |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDALLEYLECGETEVSAREVKEQFRLLNEVfDKEEGKTRLEKEFD
|.|.|| | ||.| .   .. |.   ..   .    |. |..||.
heavlegllcgdtliledditerveqiqwp.nphtdksplqqefe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3086-3190 2e-13 44.8 In-house 215-344 (350) alignment 
Range on Protein: 3086-3190
Range on HMM: 215-344/350.0
RTIKQYHFTSWPDFGVPEHPTTLLRFIH--------KVQR--ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILD------------R--KCLD-IYN
  . | ..  |.| ..  .|  .|. .          . .   . ... |..||||||||||||..|.   ......            .  |  | |  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

FVQSMRYRRCFMVQTEAQYIFIHDALLEYL
 |. .| .|  |||.  |.|||..||| | 
ivnelrkqrismvqnldqfifiYeallfyf
subfamily_PTPDC1_pd Subfamily PTPDC1 3086-3184 4.2e-08 27.8 In-house 81-170 (182) alignment 
Range on Protein: 3086-3184
Range on HMM: 81-170/182.0
RTIKQYHFtSWPDFGVPEhPTTLLRFIhKVQRENPKNAgPVVVHCSAGVGRTGTFITisCQIqqiLDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHD
. |  | | .|.|.||.   ...|  . ||     ..   | ||| || ||||  |.  | .   .  | |.  . .. .| .|   .||  |  ....
qgiyvynf.gwkDygvas.leriLdiv.kvvafalqeg.kvavhChaGlGrtGvlia..cyl...vyakrltaekaiklvrskrpksiqtreqvelvke
PTEN_1 3086-3141 6.5e-07 24.3 In-house 93-148 (196) alignment 
Range on Protein: 3086-3141
Range on HMM: 93-148/196.0
RTIKQYHFtSWPDFGVPE---HPTTLLRFIHKVQRENPknAGPVVVHCSAGVGRTGTFI
. ....|| ...|.|.|    .   . .||. ... ..   . |.||| ||.||.|| .
sgveylhf.pieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvv
PTPc_DSPc_SM00012 3087-3188 1.8e-36 119.9 In-house 1-105 (105) alignment 
Range on Protein: 3087-3188
Range on HMM: 1-105/105.0
TIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA--GPVVVHCSAGVGRTGTFITISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIH
|.|.||.|.|||.||||... .|.....|.... |..  .||||||||||||||||..... .||. .. |..||...|...| .|  |||||.||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DALLE
.||||
ralle
0038934 (Phosphotyrosine protein) phosphatases II 3090-3142 3.1e-09 32.2 In-house 81-134 (194) alignment 
Range on Protein: 3090-3142
Range on HMM: 81-134/194.0
QYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKN-AGPVVVHCSAGVGRTGTFIT
.|.   .||.|..    .||||.. |.. . ..  | |.||| ||.|||||.. 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
0048567 (Phosphotyrosine protein) phosphatases II 3091-3142 2.9e-07 25.0 In-house 40-96 (157) alignment 
Range on Protein: 3091-3142
Range on HMM: 40-96/157.0
YHFTSWPDFGvPEHPTTLLRFIHKVQREN---PKNAGPVVVHCSAGV---GRTGTFIT
.... . ||| | . ..| |||.|. .      .. ....|||.||    |||.|.| 
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig
PTPc_motif_SM00404 3106-3179 5.2e-07 24.6 In-house 67-130 (140) alignment 
Range on Protein: 3106-3179
Range on HMM: 67-130/140.0
TTLLRFIHKVqrenPKNAGPVVVHCSAGVGRTGTFITISCqiqqiLDRKCLDIYNFVQSMRYRRcFMVQTEAQY
  .|.||...     |. | |.||| ||| |..|.|.  .     .... |.. . .. ...||  ...  ...
dkvldfiena....ekkggkvlVHCqaGvSRSatliiaYl.....mryrqlslaeayefvkerR.piispnlnf
subfamily_eak_pd Subfamily eak 3111-3194 4.3e-07 23.6 In-house 226-309 (332) alignment 
Range on Protein: 3111-3194
Range on HMM: 226-309/332.0
FIHKVQRENPKNAgPvVVHCSAGVGRTGTFITISCQIQQILDRK--CLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
...| .   | .| | .. .. |  |.|.|. |   |. | ..|     . ...  .. .|   | .. |. ||....|.||   .
tlkkyihtppsfa.p.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3115-3189 7e-11 36.5 In-house 221-294 (297) alignment 
Range on Protein: 3115-3189
Range on HMM: 221-294/297.0
VQRENPKNAgPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
.. | |.|| ...|||||||||.|  .     ....  ..  |.  ... .| .|  .|||  |. ...|| |. 
lraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3120-3191 1.1e-10 35.3 In-house 262-345 (349) alignment 
Range on Protein: 3120-3191
Range on HMM: 262-345/349.0
PKNAGPVVVHCSAGVGRTGTFITISCQIQ--QILD----------RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 ..  ...|||||| ||||...|.   ..  . |            .   |.  | ..|  |  |||  ||.|.|..|||.|. 
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_CG42327_pd Subfamily CG42327 3121-3189 2.3e-14 47.8 In-house 245-314 (319) alignment 
Range on Protein: 3121-3189
Range on HMM: 245-314/319.0
KNAGPVVVHCSAGVGRTGTFITISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
.. ||.||||| ||||||. |.   .|... .  . .|| . |.|.|  |.  |.|  || ||.  | ||
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 3127-3193 5.3e-22 72.0 In-house 2-68 (69) alignment 
Range on Protein: 3127-3193
Range on HMM: 2-68/69.0
VVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
|||||.| |||||||.|  .. .|   | .||.| || ||  |  ||  | .|||||||| | |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 3127-3193 3.3e-21 69.4 In-house 1-67 (69) alignment 
Range on Protein: 3127-3193
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
|||||.| |||||||.|  .. .|   | .||.| || ||  |  ||  | .|.|||||| | |  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3193-3490 6.7e-97 319.3 In-house 1-297 (298) alignment 
Range on Protein: 3193-3490
Range on HMM: 1-297/298.0
GETEVSAREVKEQFRLLNEVfDKEEGKTRLEKEFDNIQETIH--REPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGK
|.||..|...|.... |..| .|... |....|| ..... .  .|     . .. |..|||||..|..|..|  |... . . |||||| |...|.. .
gnteieaedlkaalqklaav.kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAegSSQHVKQFQYVSWPS
||||||.||. |  ||||||.|....||.|| | .| .|  .||||||.|.. || ....|.| .|. |.| |..|. ... .  ....|.|....|||.
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpd

KGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYA
||||  |  .||....|...|...|.||..|.|| | ||.||.||   ...|.|.|  |||||||. || .|||.|.. .|| |.|. .||.| ||....
kgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 3193-3484 4.1e-82 271.0 In-house 7-294 (319) alignment 
Range on Protein: 3193-3484
Range on HMM: 7-294/319.0
GETEVSAREVKEQFRLLNEVFDKEEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAF
||..|. .... ... |    | .. .|.|| || .. .              .|. |||. |...|||.. ||  . |...|||||| |..|| . . .
gesdvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdky

IATQGPLPDTSDDFWRMVWEHKSSTIIMLAnereggKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKG
||.||||..| .|||||.||...|||..|.      | .| .|||  . . .. |.. ..|..|  .|..|.... .    .   ....|| .  || .|
iaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflGwpdvG

VPDSAIGLLDVREQVEK-WQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE--FLG
|||... |. . ..|..  ... . ..|||||| |.||||.||.   |.||.| |  |||...||.|| ||. .|... || |.| ..||  ..|
vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN6_pd Subfamily PTPN6 3195-3483 4.6e-76 250.7 In-house 2-297 (306) alignment 
Range on Protein: 3195-3483
Range on HMM: 2-297/306.0
TEVSAREVKEQFRLLNEvFDKEEGKTRLEKEFDNIQETIHREPI-VFTGTASPNRHKNRYANVIPFDKTRCKLStIPGVDGSDYINANFIEGYHKG--KA
|.. |.|.... . |..  ... .|. .|.||...|.. ... .    |.   |..|||| |..|||.|| .|.  |.| ||||||||.|..  ||  |.
tsllakeieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdks

FIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGT-QMYGFFEITLHSMKEYPDYILREFKIVDsRDAEGSSQHVKQFQYVSWPS
.||||| |..|  |||||||. .|  |.|. .| | || .| .||||. . ..||  ..|  | |.  ||||||...   .. ......| |... ||| 
yiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfksWPd

KGVPDSAIGLLDVREQVEKWQRNSG---DKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGL---VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.||| .   .||  |.|.. |...      ||||||| | |||||.| . .|.. ....||   .|. ..|. .| || |.|.  .|| | ||.| ...
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPRN_pd Subfamily PTPRN 3195-3481 2e-62 205.6 In-house 4-290 (297) alignment 
Range on Protein: 3195-3481
Range on HMM: 4-290/297.0
TEVSAREVKEQFRLLNEVFDKEEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGY-HKGKAFI
. ||. ..     .|. . |. . |.|||||.. . .    .    .. |  | .|||...|.|.|..| ||..    . |||||| .|     .  |.|
pvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayi

ATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEY-PDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKG
||||||..|  |||.||||. .  |..|.. .| |   |..|||| |...|...|. | | . .  ||..| | . . .  |  .. | || ..|||..|
atqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse..trtvtqfhflswpeeg

VPDSAIGLLDVREQVEKWQRNsGDKPIVVHCSGGCGRTGTYIATCLLIDRLK-TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
|| ||  ||. | .|.|  |     |||||||.|.||||.||.  |...||.     .|.   .  || ||||.|.. ||.||..... |
vPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0051299 (Phosphotyrosine protein) phosphatases II 3204-3483 1.6e-96 318.4 In-house 12-286 (288) alignment 
Range on Protein: 3204-3483
Range on HMM: 12-286/288.0
EQFRLLNevfdkEEGKTRLEKEFDNIQETIHRePIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTS
. .. |        |.|.|..||. ... ..  . . ..    |..|||| ...|.|..| |||...||.|||||||..|.||.....|||||||||.| 
klvlkll.....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

DDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDS--RDAEGSSQHVKQFQYVSWPSKGVPDSAIGLL
.||||||||.....|.|| .. | |.  |..|||..|...|| . .|| |.....||..|......    | .| |..|..|.| .||  |||||.  ||
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

DVREQVEKWQRnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|  ..| |... ||..|.||||| |.|||||.||  ||...|..|| |||...|. || |||||| ...||.|.|. .||.|
dflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 3205-3482 6.4e-18 59.4 In-house 8-278 (303) alignment 
Range on Protein: 3205-3482
Range on HMM: 8-278/303.0
QFRLLNEVFDKEEGKTRLeKEFDNIQETIhrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLStipgvDgSDYINANFIEGYHKGKAfIATQGPLPDTSD
...|| . . .|. .    .||...   .   | |       | .|||...|| .|... |||     | | || |...|   . || | || ||. |. 
kwkllakrtldedaniav.nefekvvsyl..ppsvsknqfvknmdknrfvdvicldhskvkls.....d.ssyihasyleldsskka.iltqlplshtaa

DFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgtQMYGFFEITLHSMKEYPDYILR---EFKIVDSRDAEGsSQHVKQFQYVSWPSKGVPDS-AIGL
|||.|. | |   ...|  . |  |   .  .|    | .  ||     . |.    |     .|..   . .     ..  .| .|| . .|   .  .
dfwqmiieqkvkcvlllltdseydklggdsvfprn..qdflkfeersirvgefkrvelgdgwvlkvlsvsngdy.ksflhvhhykawphnsipsdgspkf

LDVREQVEKWQRN-SGDKPIVVHCSGGCGRTGTYIATC----LLIDRLKTEGLVDVFQVVRGLRLQrpgMVRSVDQYEFCYKSILEF
.    |..   |. |  .| |     ||||.||.         | .   .  || ... ||  ||.    |. . |. . |  . | 
vkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlh...avqnlsqfsvvytllaeh
0050432 (Phosphotyrosine protein) phosphatases II 3211-3491 5.7e-95 313.5 In-house 33-307 (308) alignment 
Range on Protein: 3211-3491
Range on HMM: 33-307/308.0
EVFDKEEGKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLstipGvDGSDYINANFIEGY--HKGKAFIATQGPLPDTSDDFWR
. ..|  ....||.||  ....    .  ...    |..|||| ...|.|..| ||    . .|||||||... ||  .. ..|||||||||.| .||||
kllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MVWEHKSSTIIMLANEREGGKAMCHKYWPDS---GTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAegSSQHVKQFQYVSWPSKGVPDSAIGLLDVRE
||||.....|.|| .. | |.  |..|||..   |...|| | .|| |.....||..|........|    | .|..|.| .||  |||.|.  |||  |
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldfle

QVEKWQrnsGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
.|.|..   ...||||||| |.|||||.||  ||...|..|| ||||..|. || |||||| ...||.|.|. .||.| .. |..|
lvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
0047943 (Phosphotyrosine protein) phosphatases II 3213-3483 6.6e-90 296.5 In-house 5-272 (273) alignment 
Range on Protein: 3213-3483
Range on HMM: 5-272/273.0
FDKEEGKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLstipGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWE
..|  |.|.|..||. ...... .    ..    |..|||| ...|.|..| ||    | .|||||||....||.....|||||||||.| .||||||||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

HKSSTIIMLANEREGGKAMCHKYWPDSG---TQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK
.....|.|| .. | |.  |..|||..|   ...|| | .|| |.....||..|....... . |  | .|..|.| .||  |||.|   ||.  |.|.|
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrk

WQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
..... ...|.|||||.|.|||||.||  ||.|.|..|| |||...|. || |||||| ...||.|.|. .||.|
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 3213-3489 1.4e-78 258.7 In-house 13-289 (290) alignment 
Range on Protein: 3213-3489
Range on HMM: 13-289/290.0
FDKEEGKTRLEKEFDNIQEtIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-D-GSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMV
 .. .|... ...|  ..   ..|  | .|..| |...||.||... |  |  |  |.|  |   .|||| .|.||.. |..||||||...|  |||...
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKW
|..|.. |.|| |. | ||  |..|||||.|..|| |.|.|.. ... .|| |.... ... | |..|.|.|.|  .|.|.|      . | | |...| 
wqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemykt

QRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
|| .|...||||||.. ||.....|.   |.. |||| .|||||.. .| |.||.| .|.||.. .. .|. | ||.||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0039614 (Phosphotyrosine protein) phosphatases II 3214-3487 1.3e-89 295.9 In-house 26-293 (297) alignment 
Range on Protein: 3214-3487
Range on HMM: 26-293/297.0
DKEEGKTRLEKEFDNIQETIHrePiVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-DGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVW
.|  .||.|..|| .... ..  .   ..    |..|||| ...|.| .| ||....||  .||||||....||.. ...|||||||||.| .|||||||
ekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

EHKSSTIIMLANEREGGKaMCHKYWPDSGTqMYGFFEITLHSMKEYPDYILREFKIVDsrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQ
|.....|.|| .. | |. .|..|||..|. .|| | .|| . .....|..|......    .| | .|..|||..||  |||.|.  ||.. |.|....
eqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellleflelvreal

RNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFD
... ...|..||||.|.|||||.||  |....|..|| |||...|. || ||||.| . .||.|.|. .||.|  ..
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 3214-3483 6.5e-88 290.7 In-house 21-304 (307) alignment 
Range on Protein: 3214-3483
Range on HMM: 21-304/307.0
DKEEGKTRLEKEFDNIQETIHR-EPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-DGSDYINANFI--------EGYHKGKAFIATQGPLPDTS
.. ...|.|.|||  ...  ..      ..    |..|||| ...|.| || |||...|  ..||||||...        .||.....|||||||||.| 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

DDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQ-MYGFFEITLHSMKEYPDYILREFKIVDSrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLD
.|||||.||.....|.|| .. | |. .|..||||.|.. .|| | .|| |......|..| ... |. | .| | .|..|.| .||  |||.|   |||
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelld

VREQVEKWQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGL---VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
  |.|.|..... ...|..||||.|.|||||.||  |....|..||    ||....|. || ||||.| . .||.|.|. .||.|
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 3214-3492 1.1e-76 252.5 In-house 14-287 (287) alignment 
Range on Protein: 3214-3492
Range on HMM: 14-287/287.0
DKEEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLStipgVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEH
....|..  .. |  ...  .||  |  . || |..|||...... |. |  |         ||||| ||.||.. ||||....|. .|  .||......
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddr

KSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRdAEGSSQHVKQFQYVSWPSKG-VPDSAIGLLDVREqVEKWQR
. ..|.||..|.|  . .|..|||.. . ..| ..|.| . . . .|| |....  .   .|. |.|||.|. .|.|.| |.. .  || . |   | ||
nvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.kagdkqqvkqyqitnWdstgkvtepqtillviee.myktqr

NSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYANF
 .|. .|||||| . ||.....|    |.. |||| .|||||..  | |.||.|. |.||.| .. .||.| ||.||..|
krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPN14_pd Subfamily PTPN14 3214-3483 1.5e-53 176.7 In-house 17-296 (300) alignment 
Range on Protein: 3214-3483
Range on HMM: 17-296/300.0
DKEEGKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVdGSDYINANFIEGYHKG--KAFIATQGPLPDTSDDFWRMVW
.|.  .... .|...|..  . . .. |..   | .|||. .|.|....| .||.      ..||||  |.    |  . .|..||||. |  |||.|||
ekkleegkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvW

EHKSSTIIMLANEREGGKAMCHKYWPDS----GTQMYGFFEITLHSMKEYPDYILREFKIVDSRdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQV
|.. . |.||..|.|.||  ..||.|..     |  .| |..| .  .. . .| . .|.       .  . |  .||. || .|||.   | |.  |.|
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp..skeertvwhlqytDWpdhgvPeDvkgflsyLeev

EKWQRNS--------GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.  .|..         . |..|||| | ||||  | . |||  |...  .|. .|.. || ||  .|... ||.| || ....|
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3215-3488 1.8e-96 318.0 In-house 18-288 (319) alignment 
Range on Protein: 3215-3488
Range on HMM: 18-288/319.0
KEEGKTRLEKEFDNIQETIHRepIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
.. |.| ||||| ...|.      . . .   |..|||| |....|.|| .||...||.|||||||.||.||.. ..|||||.|| .| .||||||||..
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

SSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIvDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNS
||...||..  | .|  ..||||.   . || . .|| . .|  ||| |..|. . . .|  . .||.||| .|| ..||..| .|||. ....| ....
ssivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
 ..||||||| | |||||.|.    ..|.| ||..|||..|. ||.||. ||.  .||.|.|. .||.. ..||
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_PTPRB_pd Subfamily PTPRB 3215-3483 6.6e-87 286.2 In-house 20-285 (293) alignment 
Range on Protein: 3215-3483
Range on HMM: 20-285/293.0
KEEGKTRLEKEFDNIQETIHREPIVfTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
|.. ..|. .|......  . . .. . ... || |||| |..|.|..| ||... . .||||||||.|.||.  . |||||||||.| |||||||||.|
kadsdlrfseeyeelkavgkdqavk.aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekk

SSTIIMLANEREGGKAMCHKYWPDS-GTQMYGFFEITLHSMKEYPDYILREFKIVDsrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQ-R
||.|.|| .  |.||  |..|||.   ...||  ..|| . .|. |...||.||      | ....|.|....|||  |||...  |||  ..|.... .
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

NSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.. ..||||||| | |||||.||   |......| .||.| .|  || .|  .| ...|| | ....|..|
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3215-3482 5.9e-85 279.8 In-house 16-278 (288) alignment 
Range on Protein: 3215-3482
Range on HMM: 16-278/288.0
KEEGKTRLEKEFDNIqETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
. ...| ...|....  .....  | .|  . | .|||| |..|.| .| ||   . ..|.|||||..|.|..| |..|||||||.|| .|||..|.|.|
sarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

SSTIIMLANEREGGKAMCHKYWPDSGT-QMYGFFEITLHSMKEYPDYILREFKIVdsrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
.|||.||..  ||||  |..||||... . || ...|| . ||  |..||.. ..     ...  ...|.|| .|| .|||.|.  ||....||.  . .
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

SgDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
   .||.|||| | |||||.||   |||....|  .||. .|  || ||. .|  . ||||.|. .|. 
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPN12_pd Subfamily PTPN12 3215-3483 2.6e-77 254.5 In-house 3-277 (290) alignment 
Range on Protein: 3215-3483
Range on HMM: 3-277/290.0
KEEGKTRLEKEFDNIQETIHR---EPI--VFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRM
..||. ...||| ..... ..   | .    .|... |..|||| ...|.||.| .||.| ...||||||||||.| .. ...||.|||||.| ||||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

VWEHKSSTIIMLANEREGGKAMCHKYWPDS-GTQM-YGFFEITLHSMKEYP-DYILREFKIVDSrdaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQ
.||.. . ..|. .| | ||  |..|||.. .... .| ||.||.. |    |...| .|.  .    . |..|.||.| .|| .||| ||  ||.. |.
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssakslleliel

VEKWQRnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGL---VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|.. |. | |.|.||||| |.||||| ||  .  . ||.| .   .|||..|. || ||. .|.. .|||. ||...|..
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN9_pd Subfamily PTPN9 3215-3483 1.1e-75 249.4 In-house 11-290 (297) alignment 
Range on Protein: 3215-3483
Range on HMM: 11-290/297.0
KEEGKTRLEKEFDNIQETIHREpIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
||.||  | ||. .|...      . .     | .||||..|. .|.|| .|..... . ||||||||..||.. ||||||||||. |..||||||||..
kekgkrGlskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

SSTIIMLANEREGGKAMCHKYWP--DSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK---
  .|.| .   | |.  | .|||  .  .. .|.....  ...|. ||  | ..| ....  . |..|  ||..|||  |||.||  ||||.|.| .   
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

---------WQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
         |. .  . ||||||| | |||||.|.  . ..||...| |||...|. || ||  ...  .||||||...||. 
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3215-3482 7.4e-67 220.1 In-house 5-276 (287) alignment 
Range on Protein: 3215-3482
Range on HMM: 5-276/287.0
KEEGKTRLEKEFDNIQETIHREPIVFTG-TASPNRHKNRYANVIPFDKTRCKLSTIPgVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEH
. . |  ..||.|...|  .  ...|   .   . .|||||.|.|.|.||  ||. .   ||||||||.. .|.. .||||.|||.. |  ||||.|.|.
errvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravlet

KSSTIIMLANEREGGKAMCHKYWPDSGTQMY-GFFEIT-LHSMKEYPDYILREFKIVDsrdAEGSS-QHVKQFQYVSWPSKGVPDSAIGL----LDVREQ
.|...|... | | ..  |.||||.    |  | . .. |   .  |.|  | ....|   .|.   . |||....|||.|... .|.||    |||...
rsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid...letrearvvkqldllswPdkvlaPtavglirfvldvkqh

VEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
.|  .  |.  |.|||.. | ||.|...||  |..||.  | ||| .||  || .| ..|..| |. . |...  .
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPN23_pd Subfamily PTPN23 3215-3481 9.8e-62 203.4 In-house 10-278 (288) alignment 
Range on Protein: 3215-3481
Range on HMM: 10-278/288.0
KEEGKTRLEKEFDNIQETIHREPIVF-TGTASPNRHKNRYANVIPFDKTRCKLStipgVDGSDYINANFIEGYHKG-KAFIATQGPLPDTSDDFWRMVWE
. .||| |.|.| ..... ..|   . .  |  . .|||. ...|.|..| ||         ||||| |...   |   |||||.||. |. |||.||.|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

HKSSTIIMLANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKEYPDYILREFKIVDSrDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK-
 |||.|.|| .. | ||  ...||| .   |. .| ...||.| .| . .. |..|.    ||.   ..|.  |. |||. |||.|   ||.. ..||. 
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dad.avksvshlqltsWpelGvPasPetllqfldevesa

--WQRNSGDKPIVVHCSGGCGRTGTYIA-TCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
   ...  ..|.||||| | ||||..    . ...  | .||.|. |||. || ||  ||. ..|..|.|. .||
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3215-3393 9.4e-19 62.0 In-house 62-235 (244) alignment 
Range on Protein: 3215-3393
Range on HMM: 62-235/244.0
KEEGKTRLEKEF-DNIQETIHREPIVFTGTASPN-RHKNRYANVIPFDKTRCKLSTipGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWE
|.||   .. .. .  |. |. .| |.  . .||  .||| .  .|||  |  ||   |  |  |||| |.    .   .| || || ||| |||.|. |
kkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmle

HKSSTIIMLANEREGgkamcHKYWPDSGTQMYGF--FEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGV
 .   ...|    |       .|||||    .      .||    |. .    ...|    | . | | .  ||   ||| | 
rhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnlei..esdmneshqaltmfqisnwpsdgt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3216-3491 9.4e-108 355.0 In-house 16-288 (318) alignment 
Range on Protein: 3216-3491
Range on HMM: 16-288/318.0
EEGKTRLEKEFDNIQETiHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKS
|.|.. |..|..... . ....  .  . . |..||||||....|.|| ||... |. ||||||||.|.||.. ||.||.|.|||.| .|||||||| .|
esGelllseeyerlsrs.eetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqns

STIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDsrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSG
..|.||..|.| ||| .|.|||..|.. ||   ..|.. .|. ||.|||||.    . | .|..|.|..| ||| .|||.|. .|||.  ||.|.|..||
avivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg

DKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
 .|||||||.| ||||..||   |..|.| |.||||||.|. || ||. ||.  |||||.|. .||.| |.||...
agpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 3216-3482 2.7e-44 146.2 In-house 2-258 (267) alignment 
Range on Protein: 3216-3482
Range on HMM: 2-258/267.0
EEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTipgvDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKS
|. .. .||||..|..  . .  . .  |. |. .||. ...|.|.||  |.|       .|||| ..|||....|||.||.||  |  ||. .. ..| 
edeeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

STIIMLANEREGgkaMCHKYWPDSGTQMYGFFEITL-HS-MKEYPDYILREFKIvdsRDAEGSSQHVKQFQYVSWPSKGVPDSAigLLDVREQVEKWQRN
..|..| .  ..     ...||    |   . ..|. ||  ||  || .  ...   .  . |.. |  . |  |  .        |  .   . | | .
pvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtlyyykkwnintnnkpy..lkplfgilaknqle

SGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
 |..|.||.|| | ||.||..     ..|.|||| .|.|. .| .| ||.|.| . ..| ...... |.
ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Ptp69D_pd Subfamily Ptp69D 3217-3485 2.3e-83 274.8 In-house 19-288 (307) alignment 
Range on Protein: 3217-3485
Range on HMM: 19-288/307.0
EGKTRLEKEFDNIQETiHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSS
. .  |.||....... . .    ..    |  |||| ....||||| ||..|.| . ||||||.||.||.. | ||| |.|.  | .|||||..| .. 
dtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDA---EGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
.|.||.|. |  .. |.||||.  .. ||   ..| | .. .||| ||...    .    .  |..| |..| .|.   ||..| |||.. |||.. ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

SgDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
.   ||||||| | ||.|...| ..|...||.|  ||.|..|..|| ||. .|.| .||.|.|...|..   
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRG_pd Subfamily PTPRG 3217-3488 4.5e-82 271.1 In-house 16-292 (563) alignment 
Range on Protein: 3217-3488
Range on HMM: 16-292/563.0
EGKTRLEKEFDNIQETIHREPI-VFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGS-DYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
.|......||...|...  . . . .  .  |..|||| |....|..| ||| .||.... ||||||.|.||.|.||||||||||.|| ||||||.||..
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

SSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEG----SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKW
...|.|..|  | |.  |. |||  ... || ...|| . .    |  |...| . .  ..    . ..|.|..| .|| .|||....  |   .. .. 
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QRN-SGdkPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
...  |  ||||||| | |||||||.   |. ....|  |.||.... .|.||. .| . .|| | .. .|| . | .|
nkaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
0040438 (Phosphotyrosine protein) phosphatases II 3218-3487 3.5e-91 301.1 In-house 16-280 (317) alignment 
Range on Protein: 3218-3487
Range on HMM: 16-280/317.0
GKTRLEKEFDNIQETIHRepIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
..|.|..|| .... ..      ..    |..|||| ...|.| .| ||| ..|. .||||||....|......|||||||||.| .||||||||.....
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnSGDK
|.|| .. | |. .|..|||. .|. || | .|| |..|.....||.....|.   .. | .|..|.| .||  |||.|   |||  |.|..... ....
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpgg

PIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFD
|..||||.|.|||||.||  |....|..|| |||...|. || ||||.| . .||.|.|. .||.|  ..
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0036941 (Phosphotyrosine protein) phosphatases II 3218-3489 4.6e-88 290.6 In-house 11-283 (297) alignment 
Range on Protein: 3218-3489
Range on HMM: 11-283/297.0
GKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLstipGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
....|.|||. ... ..  .   ..    |..|||| ...|.|.|| ||    . .|||||||....||. ...|||||||||.| .||||||||.....
flalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IIMLANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKE--YPDYILREFKIVDSrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
|.|| .. | |. .|..|||.   ... || | .|| |...  ..||.||.....|    .| | .|..|.| .||  |||.|.  |||  |.|.|....
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

S-GDKPIVVHCSGGCGRTGTYIATCLLIDRLK---TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
. ...|..||||.|.||.||.||  |....|.   .|| ||....|. || ||||.| ...||.|.|  .||.| ...|.
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0043336 (Phosphotyrosine protein) phosphatases II 3218-3482 1.9e-87 288.5 In-house 18-276 (278) alignment 
Range on Protein: 3218-3482
Range on HMM: 18-276/278.0
GKTRLEKEFDNIQETIHrePIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
.||.|..|| ....  .  .   ..    |..|||| ...|.| .| ||| ..|. .||||||....||.....|||||||||.| .||||||||....|
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IIMLANEREGGKAMCHKYWPdSGTQMYGFFEITLHSMKEYPDYILREFKIVDsrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnSGDK
|.|| .. | |.  |..||| .|.. || | .|| ......||..| .....    .| |..| ...|..||  |||.|   |||  ..| .... . ..
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
|..||||.|.|||||.||  ||...|..|| ||....|. || ||||.| . .||.|.|. .||.
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3218-3488 3.4e-86 284.2 In-house 20-288 (305) alignment 
Range on Protein: 3218-3488
Range on HMM: 20-288/305.0
GKTRLEKEFDNIQETihrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
 .. ||.......|.   |  .. |. . |..|||.......|. |..|.. . .| ||||||....||.. |..|..||||..| .||||...| | ||
sdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IIMLANEREGGKAMCHKYWPDSGTQ--MYGFFEITLHSMKEYPDYILREFKIVDSRDaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSG
|.||.. .||||  |..|||.| |.   .| |...|.| |...||| |..||   .. .  |. | |.|  .|| .|||..|  ||.. ..|.| |... 
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

DKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
..|..|||| | ||||..||  . ..|||.|. ||||.|.. || .|..|| . ||| |..  . | . ..||
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 3219-3491 1.1e-61 203.1 In-house 14-301 (301) alignment 
Range on Protein: 3219-3491
Range on HMM: 14-301/301.0
KTRLEKEFDNIQETIHREPIVftGTASPNRHKNRYANVIPFDKTRCKLSTIPGVD--GSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSS
....|.......|. ... .|  |. . |.. ||. |. ..|. |  |.. | .|    .||||..|.|| . |.|||.|||.  |  ||||..|..| .
snkfeeqykelkegedksctv..glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIIMLANEREGGKAMCHKYWPDSGTQMY--GFFEITLHSMKEYPDYILREFK--IVDSRD-----------AEGSSQHVKQFQYVSWPSKGVPDSAIGLL
.|.|..|..|| |. |..|||.| .. .  |.|..||.. . |||...|...  | |. .           .. ||..| |.| ..||  ||       |
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

DVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
 | ..| . |.  |  |.||||| . .|.|.|..  . ..  | || ||||||.. .| ..||.|   .|| . |. | ..|   .||||
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3219-3481 1.2e-41 137.6 In-house 6-293 (297) alignment 
Range on Protein: 3219-3481
Range on HMM: 6-293/297.0
KTRLEKEFDNIQETihREPIVFTGTASPNR-HKNRYANVIPFDKTRCKLSTipGVDGSDYINANFIEGYHK--GKAFIATQGPLPDTSDDFWRMVWEHKS
.  ||.| | . .   ...  |. .  ..  .|||| ... .|.|| ||    .. ..|||||...   ..     .| .|||| .| ||||..|.|.  
rkeleaekdlllde..argesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdv

STIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLH----SMKEYPDYILREFKIVDSrdaeGSSQHVKQFQYVSWPSKGVP----D--S---------
 .|.|.|. .|.|.  |  |||..  .     .. .        |.   || |....        |..|.  |..||| .|||    |            
rvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscc

-----AIGLLD-----VREQVEKWQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
      ..|..     |  |.|  . .   . ...|||| | ||.|  . .  ....|. . . ||  ... || ||. .|....|.|..|. .|.
iavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 3219-3482 3.6e-19 63.3 In-house 25-284 (302) alignment 
Range on Protein: 3219-3482
Range on HMM: 25-284/302.0
KTRLEKEFDNIQETihREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPgvdgSDYINANFIEGYHKGKAFIATQGPLPDTS---DDFWRMVWEHKS
.....|||..|...  . ..    .   | .||.  .|   |... ||.. |     .|.||  .|  . ..  | .| |  |..   ..|||||...| 
taevkkefkkidtm..kvdlekCkafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

STIIMLANEREGGKaMCHKYWP-DSGT-QMYGFFEITLHSMKEYPDYIlREF--KIVDSRDAEGSSQHVKQFQYvsWPSKGVPDSAIGLLDVREQVeKWQ
 .. .|. | |  |   ....|  ||. . || . .     ..  .    ..   ..    ..     |. ...  |..| ||..   |    ..|   .
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv.fak

RNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
  ..|...|.    |.|| |. ..  . ...|...  . . ..|. .| ||| .| |..|| . | ..| .
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3220-3483 9.3e-79 259.4 In-house 15-276 (281) alignment 
Range on Protein: 3220-3483
Range on HMM: 15-276/281.0
TRLEKEFDNIQETIHREPIVfTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTII
. . .|......   ... .   .|  |..|||| |.. .|.|| |..       .|||||||..||.. |..||||||.|.. ..||.||||.| |.|.
aGfieeyeklaaigvdntat.askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLANEREGGKAMCHKYWPDSG-TQMYGFFEITLHSMKEYPDYILREFKIvdsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKP
|...| |.||  ||.||||   .  || . .. .. .| . || |.||.   .  .| ...|.|..|..|| .|||...  ||. |..|.| .... . |
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

IVVHCSGGCGRTGTYIATCLLIDRLKTE-GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.|.||| | ||||||||   |......|   .|| .||. || .|  ||..| |||| || .|. |
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 3220-3483 7.9e-40 131.7 In-house 16-277 (307) alignment 
Range on Protein: 3220-3483
Range on HMM: 16-277/307.0
TRLEKEFDNIqetIHREPI-VFTGTASPNRHKNRYANVIPFDKTRCKLsTIPGVdGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTI
..|  || ..    ...|  | . . | | .|||| .|   ||.|  . ...|.  |||| ||..    | | ||..|||| .|  .|| |. ..|  ..
qalvdefrvl...akktpegvtveafsantdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

IMLANEREGGKAMCHKYWPDSGTQMYGFFE----IT---LHSMKEYPDYILREFKIVDSRDAeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwq
|||..  | .|  |..|||    |   | |    |.   | . |  ||  | .   ..   | . |. ....|.  || .|||.  .. ... | |    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleav....

rNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL-KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 .    |.||||| | ||.|| .| .|. |.. . .   |. ..|. || ||.  ...  || . .. .||..
.rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3221-3483 3.8e-68 224.5 In-house 6-268 (274) alignment 
Range on Protein: 3221-3483
Range on HMM: 6-268/274.0
RLEKEFDNIQETIHREPIVFTGtaspNRHKNRYANVIPFDKTRCKL-STIPGVDGSDYINANFIEGYH-KGKAFIATQGPLPDTSDDFWRMVWEHKSSTI
 ||||| ..    ..| .  .|    . .|||| ...| ...|  | |  .  . |.|||||.| ||. . ||..||||||| | .|||||....... |
dlekeflelPlnfdqeeldvfg....sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

IMLANEREGGKAMCHKYWPDSGTQ----MYGFFEITLHSMKEYPDYILREFKIVDSRDaegsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNS
.||.. .|  .. |..|.||.        || .||. ....|  || .|.. .  . .    ...|| . | .|| . .||.|  |||. ..||. ....
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreee

GDK--PIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
  |  |.||||| | |||| .||. . . .|. |. |||...|  |||.| |||.. .|||. .. . ..|
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
0049772 (Phosphotyrosine protein) phosphatases II 3221-3483 6e-48 159.5 In-house 20-280 (314) alignment 
Range on Protein: 3221-3483
Range on HMM: 20-280/314.0
RLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDkTRCKLsTIPGVDGSDYINANFIEGYhkgKAFIATQGPLPDTSDDF----------WRMV
.|. ...... .. .| .. ..   .||.|||| ...|.| .| .|    .|.|||||||... |.   ..||||||||. | .||          ||||
klllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmv

--WEHKSSTIIM---------------------LANEREGGkamchKYWPDSGTQMYGffeitlhsmkeypdY-------IlrefkivdsrdaegsSQHV
  ..... .| |                     | .  ..|      ... .  ...                                       ....
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf...............erlg

KQFQYVSWPSkGVPDSAIGLLDVREQVEKWqrnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKteglVDVFQVVRGLRLQRP-----GMVRSVDQYEFC
 .. .. .|  | ...   .... | .|..   . ..|..|||..|.|||||......|. .|.    |.. .... .||.||     |.... .||||.
ikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefi

YKSILEFL
.. .||.|
lealleyl
0046845 (Phosphotyrosine protein) phosphatases II 3222-3491 3.2e-91 300.9 In-house 2-282 (284) alignment 
Range on Protein: 3222-3491
Range on HMM: 2-282/284.0
LEKEFDNIQETIHREP-IVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-DGSDYINANFIEGY-----HKGKAFIATQGPLPDTSDDFWRMVWEHK
||.||  ..   .     . .. .  |..|||| ...|.|..| ||....|  ..||||||....||     .. |.|||||||||.| .||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SSTIIMLANEREGGKAMCHKYWPDSG-TQMYGFFEITLHSMKEYPDYILREFKIVDSrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
...|.|| .. | |. .|..|||..| ...|| | .|| |.....||..|......  . .| | .|..|.| |||  |||.|.  ||.  ..|.....|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-SGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEG---LVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
 .|..|||||||.|.|||||.||  ||...|..||    |||...|. || |||||| ...||.|.|. .||.| .. |...
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
DSPc_SM00195 3222-3483 3.3e-85 280.9 In-house 2-262 (263) alignment 
Range on Protein: 3222-3483
Range on HMM: 2-262/263.0
LEKEFDNIQETIHREpIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
|..||....|  . .  . ..  . |..|||| |..|.|.|| ||..... .||||||||.|.|..| |..||||||||.| .||||||||.|...|.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

ANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKEYP-DYILREFKIVDSRDaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSgDKP
 .| | ||  |..|||..  |.. .| ....| . .... ..|||....    .    .. |.|.|| .|| .|||||.  .|.. ..|.|....| ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

IVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. .|| |.|. |||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 3222-3483 3.3e-85 280.9 In-house 2-262 (263) alignment 
Range on Protein: 3222-3483
Range on HMM: 2-262/263.0
LEKEFDNIQETIHREpIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
|..||....|  . .  . ..  . |..|||| |..|.|.|| ||..... .||||||||.|.|..| |..||||||||.| .||||||||.|...|.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

ANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKEYP-DYILREFKIVDSRDaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSgDKP
 .| | ||  |..|||..  |.. .| ....| . .... ..|||....    .    .. |.|.|| .|| .|||||.  .|.. ..|.|....| ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

IVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. .|| |.|. |||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 3222-3485 2e-67 222.3 In-house 13-271 (273) alignment 
Range on Protein: 3222-3485
Range on HMM: 13-271/273.0
LEKEFDNIQEtIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGvdgsdYINANFIEGYHK--GKAFIATQGPLPDTSDDFWRMVWEHKSSTII
 ..||....| ..    . .|    |..|||| ||.|.|.|| ||.   |     ||||..|.         .||.|||||.| .|||.|||| |.. |.
Paeefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLANEREGGKAMCHKYWPDSG---TQMYGFFEITLHSMKEYPDYILREFKIVDSRdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnsGD
|...|.|.||  ||.|||.|    ..... .|..|  .... .. .|.... ||.   | |..| ....|.||  ||| ||  || .  .| . |.    
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..da

KPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
 ||||||| | ||.||.|.   ... .. .  .|| ..|| || || |.|.. ||| |.||.||| |.|
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_eak_pd Subfamily eak 3222-3394 6.7e-15 49.3 In-house 31-195 (332) alignment 
Range on Protein: 3222-3394
Range on HMM: 31-195/332.0
LEKEFDNIQETIHREpivfTGTASPNRHKNrYANVIPFDKTRCKLSTiPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
. ...|. |.    .     ..   . ..|   ...|.|.   .|..    .   ||||  .|  . |. .| |  .  |    ||.|| | || .|..|
ivadlddyqrllsis....etarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivql

ANEREGGKAMCHKYWPDSG--TQMYGFFEITLHSMKEYPDYILREFKIVDSRDaegsSQHVKQFQYVSWPSKGVP
... | .     ||.|| .     .|.....  .  .   .  | ...    .    . .|. ...  |    .|
ledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGne....thrvlhykvfGwtettlp
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3223-3483 2.2e-64 212.5 In-house 23-279 (439) alignment 
Range on Protein: 3223-3483
Range on HMM: 23-279/439.0
EKEFDNIQETIHREPIVFTG-TASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
...|..|. |      . .  . . .. |||| .| .|| ||  |  ||||  | |||||.|.||.. | .||||||  .|.|||||.|.|.|..||.||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

ANEREGGKamchkYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVV
.|  |  |     ||| ..  .||   .      | |.|..| ||... ||     . | ||.|..|| | ||  |  .||    ..  . .    |.||
tnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvv

HCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
||| | ||||| ||  . ...||.|  ||.  .|. || ||  ||... || | |...|| .
hcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_PTPN1_pd Subfamily PTPN1 3223-3481 3.5e-52 171.9 In-house 5-269 (290) alignment 
Range on Protein: 3223-3481
Range on HMM: 5-269/290.0
EKEFDNIQETIHREPIVFTG---TASPNRHKNRYANVIPFDKTRCKLSTIPGvdgsDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTII
.. ...| ..|..|   |.        || .||| .| |.|..| ||         |||||...|  .  . .| ||||||.| | ||.||||.|| ...
krlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MLANEREGGKAMCHKYWPDSGT--QM-YG--FFEITLHSMKEYPDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN-
|| .  | ..  |..|||      .. .    ....| | ...  |..| ... . .  |  .... .| |..||  |||.|   .|.   .| .     
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdfgvpespaaflkflfkvresGsls

SGDKPIVVHCSGGCGRTGTY--IATCL-LIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
|   | |.||| | ||.||.  . ||| ||.. .    ||. .|.  || .| |...  || .| | .|||
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_ptpA1_pd Subfamily ptpA1 3223-3443 2.3e-40 133.6 In-house 24-256 (418) alignment 
Range on Protein: 3223-3443
Range on HMM: 24-256/418.0
EKEFDNIQETIHREPiVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHkGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLA
..||  ..|..        |    |  ||||.|..| ..|| .|  |   .||||||||.|.| .  | ||.||||||.|  |||||||| .   |.||.
keefrlleesvgpse.tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmls

NEREGGKAMCHKYWPDS-----------GTQMYGFFEITLHSMKEYPDyilREFKIVDSR-DAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKW
 | |  .  | .|||.            | ...| . . |  . . |.   ||    . |   || .. . |.||  || . .|| .  . ..   . . 
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe...reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

QRN---SGD--KPIVVHCSGGCGRTGTYIATCLLIDRL
| .   | |   ||.|||| | |||||. .. ... .|
qnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_CG42327_pd Subfamily CG42327 3223-3402 9.8e-30 98.3 In-house 8-185 (319) alignment 
Range on Protein: 3223-3402
Range on HMM: 8-185/319.0
EKEFDNIQETIHREPIVFTGTaspnRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGK-AFIATQGPLPDTSDDFWRMVWEHKSSTIIML
 .||...   | |   | ...    . |.|..||.|. .||  |  |.  | . |..|... ||.. .  .||.| .| |.| ||||.||| .| .|. |
aeefrdlPqliaradevPvts....kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivql

ANEREGGKAMCHKYWPDS----GTQMYGFFEITLHSMKEYPDYILREFKIvDSRDAEgSSQHVKQFQYvSWPSKGVPDSAIGLLD
..  | |  .| .|.| .    .|..|| . .||   .    |..  . .    | |  |...  . |  |.  .|| .   |. 
tdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.krvdke.esrelthywy.kwleaevPaeeaalia
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3223-3297 6.8e-11 36.2 In-house 22-95 (95) alignment 
Range on Protein: 3223-3297
Range on HMM: 22-95/95.0
EKEFDNIQETIHRE--PIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIpgvDGSDYINANFIEGYHKGKAFIATQG
..||||   .|         .|..  |  |||. |..|.| ||  |.|      |||||| |..|| . ...||.||
dqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_egg_pd Subfamily egg 3225-3483 7.3e-28 92.1 In-house 19-270 (307) alignment 
Range on Protein: 3225-3483
Range on HMM: 19-270/307.0
EFDNIQETIHREPIVfTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANE
 .  ..|.......  |  .. |..| |   |   | .| ||    |    |.| || ..|      || .| || .| |||||||.. .   |.||.  
rlevleesvdeislt.taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr

REGgkAMCHKYWPDSGTQMY----GFFEITLHSMKEYPDYILR--EFKIVDSRDAEgssQHVKQFQYvSWPSKGVPDSAIglldvreQVEKWQRNSgDKP
.|     |. ||| . ..      | ..|.   ... .| ..|  ..|.| . | |   .... .|.  .   .   | .       .| .  ||   ||
kes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddee...rflehwqg.dvnnssdvyspl.......rvlrklrnl.skp

IVVHCSGGCGRTGTYIATCLLIDRLKTEGL--VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.||..  |. ...| .|  . .  |    .    | . |  |||.|.  | || .| | |. .| |.
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3233-3489 1.2e-65 216.5 In-house 34-290 (297) alignment 
Range on Protein: 3233-3489
Range on HMM: 34-290/297.0
IHREPIVFTGTASPNR---HKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKgkAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGK
   |  ....| . ..   .|.||.|..|.|. | ||  .     |||.|| |..|...   .|.|| | ..| .|||.||.... |||.||... |. |
clpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk

aMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPD--SAIGLLDVREQVEKWQRNSGDKPIVVHCSGGC
  | .||.|.|.. .|   ..|.|..|   .| ||...  ....  . . |||.|.|.||.| |.   ||  ||.. ..|.|   .  . |..|||. | 
.kcaryWsdkgvttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

GRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
|||| ...    . . | |  ||.|..|. || .|| .|.  .||.| |. .||.| | || 
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3234-3487 1.1e-66 220.2 In-house 34-292 (325) alignment 
Range on Protein: 3234-3487
Range on HMM: 34-292/325.0
HREPIVFTGTASP-NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKsSTIIMLANEREGGKAMC
  ..| .. .. | |. |||. ||...||.|  | |      ||||||.... . | . |.|.| ||..| .|.||.| . . ...... || ..||  |
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrc

HKYWPDS--GTQMYGFFEITLHSMKEYPDYILREFKIVDSRdaEGSSQHVKQFQYVSWPSKGVPDSAI---GLLDVREQVEKWQRN--SGDKPIVVHCSG
 .|||.    .. .| .|. | ...|. ||. | ... . .  .| .. |||||. ||.  ||.        .|.. ..|..  .    .  ||.|||| 
avywpkemgksktfGglevklrtieeisdyvhrvldvkqvk..kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFD
| ||||..|.   ..... .|  ||.|..|. || .|| ||..|||| ..|... |.. | .
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
0045098 (Phosphotyrosine protein) phosphatases II 3239-3484 1.1e-79 263.0 In-house 25-273 (278) alignment 
Range on Protein: 3239-3484
Range on HMM: 25-273/278.0
VFTGTASPNRHKNRYANVIPFDKTRCKlstipgvdgsDYINANFIEGYhkGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPD
....    |..|||| ...|.| .| |          |||||..|.||  .|.|||||||||.| .|||||.||.....|.||... |.|.  |..|||.
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

SGTQMYGFFEITLHSMKEYPDYILREFKIVDS--RDAEGSSQHVKQFQYVSWPSKGVPDSA--IGLLDVREQVEKWQR------------NSGDKPIVVH
.|.. || |..|| |.....||.|| .....   ..... | .|....|..||  |||..     .|.. |.......            .....|..||
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSGGCGRTGTYIATCLLIDRLktEGLVDVFQVVRGLRLQRPG-MVRSVDQYEFCYKSILEFLG
|| |.|||||..|  |....|  || ||....|. || |||| .| . .||.|.|. .||.| 
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 3239-3325 3.4e-06 20.1 In-house 19-78 (169) alignment 
Range on Protein: 3239-3325
Range on HMM: 19-78/169.0
VFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINAnfiegyhkgkafiatqgplpdtsddfwRMVWEHKSSTIIMLANER
 |    . |  ||| |  .   .|| ||  .    |||||||                           ||.||  .| |..| .  
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 3240-3483 1.4e-29 97.7 In-house 46-289 (305) alignment 
Range on Protein: 3240-3483
Range on HMM: 46-289/305.0
FTGTASP--NRHKNRYANVIPFDKTRCKLSTIPgvdGSDYINANFIEGY-HKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYW
|    |.  .  ||||..|   |..  ||.  .    |||| ||..       | ||..|||| .| |.|| || ..|   |.||..  | ||  | .||
fnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PDSGTQMY----GFFEITL---HSMKEYPDYILREFKIVDSrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRNSgDKPIVVHCSGGCGR
| .  .      |     .   . |.  ..  .  ...  |    . .  |...|.  || .|||   .  |..   .    | |   ||||||| | ||
paaqgeklelksgivvenvsgskpmerdaeiqitllnltys...gdqkmsvrhlqwtewpdrgvppckltslellsai....rgs.kvpivvhcsagigr

TGTYIATCLLIDRLKTEG-LVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
||| .|   .....  .     . ..|. || ||   ...  || | .. .|...
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 3240-3325 4.6e-06 19.6 In-house 19-77 (169) alignment 
Range on Protein: 3240-3325
Range on HMM: 19-77/169.0
FTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINAnfiegyhkgkafiatqgplpdtsddfwRMVWEHKSSTIIMLANER
|    . |  ||| |  .   .|| ||  .    |||||||                           ||.||  .| |..| .  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtd
subfamily_PTPRA_pd Subfamily PTPRA 3242-3485 2.2e-85 281.5 In-house 53-297 (330) alignment 
Range on Protein: 3242-3485
Range on HMM: 53-297/330.0
GTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGT
 .   |..|||. |..|.| .|  ||.. ||. |||||| ||.||.. . |||.|||. .| .|||||.||.||.||.||.. .|  .  |..|||| |.
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl

QMYGFFEITLHSMKEYPDYILREFKIVDSRDAE--GSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDkPIVVHCSGGCGRTGTYIATCLL
  ||   .... ...  || .|.| . .  ||    .|. |.|| . |||  |||  .||.|.. ..|.| ...|.. ||||||| | |||||.|.   .
vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldav

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
..|.|.|..||||..|. |||||| ||..  ||||.|| .||.   
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_CG7180_pd Subfamily CG7180 3242-3483 1.8e-64 212.2 In-house 37-290 (296) alignment 
Range on Protein: 3242-3483
Range on HMM: 37-290/296.0
GTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKaMCHKYWPDSGT
|  . || |||. .|.|.|..|  |... | . |||||| ..... | |..| |..|  .| |.|||.|.....|....|... .  | |...|||  . 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnksk

QMYGFFEITLHSMKEYPDYILREFKIVDS--------RDAEGSSQHVKQFQYVSWPS-KGVPDSAIGLLDVREQVEKWQRNS----GDKPIVVHCSGGCG
. || ... . ..|.|..   |.||..          .. .     ||.||.  |.. . || |. .|...|..|..|...       .|.||..| | .
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|.| |.|    .. .. |. ||||. |. || .||..| .|..| ..|  .||..
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 3243-3488 3e-58 192.0 In-house 29-271 (283) alignment 
Range on Protein: 3243-3488
Range on HMM: 29-271/283.0
TASPNRHKNRYANVIPFDKTRCKLSTIPGvdgsDYINANFIE---GYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDS
.|. |..|||. ...| |. | .| . .     ||||| ||     |...| .|..|.|| .|  |||.||...| ..|.||.. .|. .  | .|||  
sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

GTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQhVKQFQYVSWPSKGvPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLL
|.. || | .||.       .| .|. .  .  |. .   .  .|.. | . | ... |  |   ..|   |..| . ||||||| | |||...||    
GsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
.. ..|| .||||.||. .| ||...|.. ||| . .. .||     ||
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdt
subfamily_PTPRK_pd Subfamily PTPRK 3244-3481 2.3e-82 271.3 In-house 40-275 (314) alignment 
Range on Protein: 3244-3481
Range on HMM: 40-275/314.0
ASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQm
   ||.|||. .....|..| .| || |   ||||||..|..|.. .|||.|||||..|  ||||.|.......|.||..  | |.  | ||||. ... 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

YGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNsGDKPIVVHCSGGCGRTGTYIATCLLIDRL
|| ....| ...   ... | |..  .  .    . |.|||...||. .|| || |||..  .|.|.| . .. .|||||| |.|||||.|| . ..| .
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
..||.||||..|. || ... ||   .|| |.|  |||
eregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3244-3488 1.6e-75 248.9 In-house 46-284 (315) alignment 
Range on Protein: 3244-3488
Range on HMM: 46-284/315.0
ASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgTQM
 . |..|||| |.|..||.| .|  .   ..|||.|||||.|| | . .||.|||.. . .||||.|.|.. ..|.||.|  || | .. |||||    .
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kvi

YGFFEITLHSMKEYPDYILREFkivdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGdKPIVVHCSGGCGRTGTYIATCLLIDRL
|| . .|. | . . .|  | .    |   .   ..| |..| |||  ||| ..| |...  .| ... ||   .|||||| | |||||.|.   ..|..
yGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqa

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
..| ..||.....|.| .| .||....||.| |. .|| .   ||
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3244-3484 3e-64 211.8 In-house 41-278 (315) alignment 
Range on Protein: 3244-3484
Range on HMM: 41-278/315.0
ASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPD--SGT
 . | .|||| |..|.|..| ||  |     |||||| .|..... ||.||.||||. . |||||||...| .||.|... .|| |  | .||||  . .
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

QMYGFFEITLHSMKEYPDYILREFkivDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWqRNSGDKPIVVHCSGGCGRTGTYIATCLLID
  .| ....| |..   | . |..     |..| .|. | |||.  || |||.  .  || .  .|    ... . ...|||| | ||||  |.    ..
vefGsikvellsleadtdgvarkl...vtrkse.esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

RLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLG
..| .  ||||..|. || .|| .|.. ..| | | ..|| | 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRD_pd Subfamily PTPRD 3245-3490 2.7e-108 358.1 In-house 46-288 (564) alignment 
Range on Protein: 3245-3490
Range on HMM: 46-288/564.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
. |..||||||....|..| .||...|..|||||||.||.||.| ||.|||||||..| .||||||||..||||.|| . .| ||  ||||||..||. |
paNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety

GFFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
| ...||.. .|. ||..|.||.  ..  . .|. |.||...|||..|||.|| .|||....|.... ... .||||||| | |||||.|.   ...|.|
geltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerik

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYA
.|..||..|.|. || ||. || . .|| |... |||.| ...|  
eektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3245-3491 4.5e-84 276.6 In-house 7-250 (250) alignment 
Range on Protein: 3245-3491
Range on HMM: 7-250/250.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAmCHKYWPDSGTQMY
  |..|||||..|..|..|  | .  | . |||||| |..||.. ||||||||||..|  ||||||.|.||.||.||.| .| .|  .|.|||  ... |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GFFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
|   ..|.| .|. ||. |..|.  |.  . ....|.|...|.|| ||||. |   |.....|.. |...|..|..|.|| | ||.|..||   ...|||
Gdvtvsllskeefadytkrklkl..skakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
.|  ||||.|.. || .||..|.| .|| |.|. ||..| |.. ||.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
0040439 (Phosphotyrosine protein) phosphatases II 3245-3483 2.3e-82 271.6 In-house 9-246 (249) alignment 
Range on Protein: 3245-3483
Range on HMM: 9-246/249.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
  |..|||| ...|.| .| ||| .||. .||||||..|.||. ...|||||||||.| .|||||.||.....|.|| .. | |.  |..|||..|.. |
penkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

GFFEITLHSMKEYPDYILREFKIVDSrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRL
| | .|| |.....||..|.......   .|.| .|...||..||  |||.|   |||  |.|.|....   ..|..||||.|.|||||.||  |....|
gdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
..|. ||....|. || ||||.| . .||.|.|. .||.|
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 3245-3484 5.9e-79 260.5 In-house 23-258 (284) alignment 
Range on Protein: 3245-3484
Range on HMM: 23-258/284.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLAnereggKAMCHKYWPDSGTQMY
 .|. |||. ....|||.. ||  . |...|||||| ||.|| . . .|||||||..| .|||||.||...|||..|.      | .| .|||  . . .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

GFFEITLHSMKEYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK-WQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL
. |.. ..|..|  .|..|.... .    .   ....|| .  || .||||... |. . ..|..  ... . ..|||||| |.||||.||.   |.||.
erfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE--FLG
| |  |||...||.|| ||. .|... || |.| ..||  ..|
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN3_pd Subfamily PTPN3 3245-3481 4.3e-64 211.1 In-house 39-273 (280) alignment 
Range on Protein: 3245-3481
Range on HMM: 39-273/280.0
SPNRHKNRYANVIPFDKTRCKLSTIPGvdgsDYINANFIEGYHKG----KAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSG
. | .|||| ...|.|.|| ||.  .     ||||||...    .    . .|||||||..|. |||.||||.|||.|.||..  | |.  ||.|||...
penlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete

T-QMYGFFEITLHSMKEYPDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwQRNSGDKPIVVHCSGGCGRTGTYIATCLL
  . || |...... .|   |.|||. . |..  |  .... |.||..|| .||||..  .|.. |.|.| .|.. ..|.|||||.| |||| .|.  . 
deleygefsvkcekedetksyvlrelvlkdketke..erkilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlilleta

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.  . ..  | . ..|| .| ||  .|....||.|  ..||.
lalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3245-3483 1.9e-57 189.3 In-house 18-264 (270) alignment 
Range on Protein: 3245-3483
Range on HMM: 18-264/270.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQ-
  ... ||||...|  .|| .|...   . . |||||...|...  |..||..|||| |  .||||.||.|...|.|...  | |.  | .||| .  . 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

---MYGFFEITLHSMKEYPDYILREFKIVdsrdAEGSSQHVKQFQYVSWPSKGVPDSAI------GLLDVREQVEKWQRNSGDK-PIVVHCSGGCGRTGT
   ..|. ...  | .    |||.. ..      .|.....  |.|..|| .||| ..        || . ..| .....  .. |..|||| | |||||
vkledgkikvlalseekeegyiltrlrle....ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

YIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 ||.   .  |.... ||| .... || .|. .|. ..|||| ||...|. 
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3245-3483 1.4e-47 156.9 In-house 43-236 (392) alignment 
Range on Protein: 3245-3483
Range on HMM: 43-236/392.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGkamchkywpdsgtqmy
  | .|||| |..|.|..| ||  |  .  |||.|| .|....  ||.||.||| . . |||||||.... .||.|... .||                 
einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................

gffeitlhsmkeypdyilrefkivdsrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVeKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
                               . . | ||... || |.||  .  || . ..| | .  .  .|...||| | ||||  |.   .. . |
............................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahak

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.  .||||..|  .| .|| ||.. .|| | | ..|| |
ktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3245-3482 6.4e-42 138.2 In-house 54-282 (290) alignment 
Range on Protein: 3245-3482
Range on HMM: 54-282/290.0
SPNRHKNRYANVIPFDKTRCKLSTipGVDGsDYINANFIEGYHkgKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
 .. .|||| .|.  ||||  |.   | || ||. ||...| .    || |||.| ||  |.|||| ..| ..|.|| .  | ||| |..|.|.   .. 
ntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

GFFEITLHSMK-EYPDYILrEFKIVDSRDA-EGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrNSGdkPIVVHCSGGCGRTGTYIATCLLIDR
 | |||.   . . .|  .   |..  ||  .| .  .| .. .||| | |. |.. || .   . |    ||  |.||||| | |||||..|    .. 
tfGeitvlcseeddkdani.ikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asG..pvvvhcsaGiGrtGtfvaievglqi

LKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
|     .|. ..|| ||  | . |.   ||    . .|..
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3245-3483 7e-33 108.8 In-house 33-270 (285) alignment 
Range on Protein: 3245-3483
Range on HMM: 33-270/285.0
SPNRHKNRYANVIPFDKTRCKLSTipgvDGSDYINANFIEGYHKGK-AFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQ-
  |   ||||.|   ..||  |         ||| |...    | . ..|.||||||.|  |||.|... | . ..||.   |||   |  |.|.   . 
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-MYGFFEITLHSMKEY--PDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWqrNSGDKPIVVHCSGGCGRTGTYIATCLL
  .| .||||   ||      ||  . .... ||     .... |   || .  |. |  .... . |.|   |  .|||.|||| | ||| |..     
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidya

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
  |.  .  ......|| .|  |   |.|  |. | |  ..|..
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0042113 (Phosphotyrosine protein) phosphatases II 3246-3483 5.2e-81 266.9 In-house 8-243 (245) alignment 
Range on Protein: 3246-3483
Range on HMM: 8-243/245.0
PNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYG
 |..|||| ...|.| || ||| ..|  .||||||... ||.  . |||||||||.| .|||||.||....||.|| .| | |.  |..|||..... ||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

FFEITLHSMKEYPDYILREFKIVDsrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKT
 | .|| |.. ..||..|......  . .. |..| ...|..||  ||||.   |||. | |.|........|..||||.|.|||||.||  |....|..
dftvtllseehlddytvrtlevtn..lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

EGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|. |.....|. || ||||.| . .||.|.|. .||.|
elgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 3246-3482 1.2e-73 243.0 In-house 9-241 (243) alignment 
Range on Protein: 3246-3482
Range on HMM: 9-241/243.0
PNRHKNRYANVIPFDKTRCKLstipgvDGSDYINANFIEGYHKgkaFIATQGPLPDTSDD----FWRMVWEHKSSTIIMLANEREGGKAMCHKYWPdsGT
 |..|||| ...|.| .| ||      .||||||||.|... .   .||||||||.| .|    ||||.||.....|.|| .. | |.  |..|||  |.
enlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..ge

QMYGFFEITLHSMKEYPDYILREFKIVDsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN-------SGDKPIVVHCSGGCGRTGTYI
..|| |..|| |.....||..|.....   |... ...| ...|..||  |||||   |||  ..| .....       ....|..||||.|.|||||.|
vtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

ATCLLIDRLkteGlVDVFQVVRGLRLQRPG-MVRSVDQYEFCYKSILEF
|  |....|   | ||....|. || |||| .| . .||.|.|. .||.
aaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3246-3483 1.1e-31 104.6 In-house 36-269 (281) alignment 
Range on Protein: 3246-3483
Range on HMM: 36-269/281.0
PNRHKNRYANVIPFDKTRCKLST-IPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
 | .||||.|.  .| .| .|   .|  . .||| ||.|      . .| ||||  .|  |||||.|. ....|.||..  |  .  | .|.|       
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

GFFEITLHSMKEYPDYILREFKIVdsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
 | ....       .  |   ..      || .. . .. .  ||   ||.|.  .| .  ..    | .   | |.||| | ||.|| .|  . .. ..
qfdklsvsyedstvnkslvttrln..lsyegetrlithwlwkewpdwqvpessevmlkilrki....r.arstppvihcsagvgrsgtlmaveialqsih

TE-GLVDVFQVVRGLRLQ-RPGMVRSVDQYEFCYKSILEFL
.   | |. |.|  ||.  |   |....|| . .| .|.| 
shftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3246-3483 4.1e-31 102.9 In-house 47-287 (305) alignment 
Range on Protein: 3246-3483
Range on HMM: 47-287/305.0
PNRHKNRYANVIPFDKTRCKLstiPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYG
 ...|||| .|  .|. | ||    |    .|| ||..    . | || || || .|  ||| | ...|  .|.|| |  | |   |..|..    ..  
qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FFEITLH------SMKE-----YPDYILREFKIVdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRNSgDKPIVVHCSGGCGRTGTYI
| |   .      | ..       .  ..| ..|    . .....|... .. || .||| . . .|.. |.     | |   ||||||| | ||||. .
feekgqkisvkfessvtlkfrkdakakvtetvlv.iegpgekarkvthyhwidwpdrgvpaadlailelleka....rps.kgpivvhcsagigrtgsvv

ATCLLIDRLKTEGLV-DVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
    ..|.| .   . |  .... .| ||   ... .|| | .. ||...
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 3246-3479 1.2e-30 101.1 In-house 51-286 (310) alignment 
Range on Protein: 3246-3479
Range on HMM: 51-286/310.0
PNRHKNRYANVIPFDKTRCKLsTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSG-TQMY
 . |||||..|.  |..| || .|      ||| ||..   .  ..|| .||||  |  |||||... .. .|..| .  | |.  |  |||  | |. |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GFFEITLH--SMKEYPDY-----ILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwQRNSGdkPIVVHCSGGCGRTGTYIATC
|   .|    | .|.        .. .   || . |.     |.  ..  || .||||     .  |      |   |  | ||||| | .|... .|  
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla...qvrhg..pcvvhcsagkdrlyvvvalk

LLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSI
| ||.|.    ||. .|.  |. .|   ...  || .  .  
lkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3246-3285 4.4e-06 20.3 In-house 46-85 (440) alignment 
Range on Protein: 3246-3285
Range on HMM: 46-85/440.0
PNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEG
 |. |||| |.. .|..|  |  . ||  |||||| .|.|
nnkvknryrnilaydhsrvmleevkgvpdsdyinasying
Y_phosphatase Protein-tyrosine phosphatase 3247-3481 1.1e-79 262.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 3247-3481
Range on HMM: 1-235/235.0
NRHKNRYANVIPFDKTRCKLstiPGVDG-SDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQM
|..|||| ...|.|||| ||    | .| |||||||...||.. |.||||||||..| .|||||||..|...|.||... | |.  |..|||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFFEITLH-SMK-EYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrNSGDKPIVVHCSGGCGRTGTYIATCLLID
|| ....|  . | .  .|.||.... .. . .  ...|||..| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|  .|..
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.|..|. |||.|.|. || |||||| |..||.|.|| |||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 3247-3481 1.1e-79 262.5 In-house 1-235 (235) alignment 
Range on Protein: 3247-3481
Range on HMM: 1-235/235.0
NRHKNRYANVIPFDKTRCKLstiPGVDG-SDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQM
|..|||| ...|.|||| ||    | .| |||||||...||.. |.||||||||..| .|||||||..|...|.||... | |.  |..|||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFFEITLH-SMK-EYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrNSGDKPIVVHCSGGCGRTGTYIATCLLID
|| ....|  . | .  .|.||.... .. . .  ...|||..| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|  .|..
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.|..|. |||.|.|. || |||||| |..||.|.|| |||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3247-3483 4e-65 214.9 In-house 43-276 (515) alignment 
Range on Protein: 3247-3483
Range on HMM: 43-276/515.0
NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPD--SGTQMY
| .|||| |..|.|..| ||  |     |||.|| .|....  ||.||.|||.. . |||||.|.... .||.|... .|| |  | |||||  . .  .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GFFEITLHSMKEYPDYILREFKIVDSRDaegsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVeKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
| ... | |..   . | |..... . |    |. | ||..  || ||||  .  || .  .| | ...    |...||| | |||| .|.    . . |
Gsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahak

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|   ||||..|. .| .|| .|.  .|| | |  .|| |
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3247-3481 3.5e-54 178.5 In-house 7-238 (239) alignment 
Range on Protein: 3247-3481
Range on HMM: 7-238/239.0
NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgTQMYG
|. ||||||.. .|..|  |  .     ||||||...  |    ||.||||| .  .| |||||.|. .   |.||.   || |  ||.||||| |  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

FFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKT
 . .||.  . . |||.| | .  |.  .   ..| |...  || ||||. |  .| .| .. | .   | .| |.||| | ||||...    .. . | 
nlrvtlrktevfadyiirtfvm..sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.  ||.|. |. .| .|| ||.. .|| | . ..||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3247-3481 4.5e-54 178.1 In-house 8-239 (239) alignment 
Range on Protein: 3247-3481
Range on HMM: 8-239/239.0
NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgTQMYG
|. ||||||.. .|..|  |  .     ||||||...  |    ||.||||| .  .| |||||.|. .   |.||.   || |  ||.||||| |  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

FFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKT
 . .||.  . . |||.| | .  |.  .   ..| |...  || ||||. |  .| .| .. | .   | .| |.||| | ||||...    .. . | 
nlrvtlrktevfadyiirtfvm..sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.  ||.|. |. .| .|| ||.. .|| | . ..||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 3247-3481 1.4e-53 176.5 In-house 3-237 (237) alignment 
Range on Protein: 3247-3481
Range on HMM: 3-237/237.0
NRHKNRYANVIPFDKTRCKLSTiPGVdGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSG-TQMY
|. ||||.|.. .|..|  |   .|  |||||||....|.    | .||.||||  . ||||.|||. | | |.||.   || .  ||||||..   . |
nkiknrygnivaydhsrvvlkg.ags.gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GFFEITLHSMKEYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN-SGDKPIVVHCSGGCGRTGTYIATCLLIDRL
| . ..|.  .|. || .| . ..     .   . ..|.|. ||| .|||. .  ||  | .. .  .  |   | ..||| | |||| ..    .. . 
gvltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
| . .||... |  .  .|| .... ||| | ...|||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 3247-3483 1.2e-49 163.7 In-house 1-171 (182) alignment 
Range on Protein: 3247-3483
Range on HMM: 1-171/182.0
NRHKNRYANVIPFDKTRcklstipgvdGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLAnereggkamCHKYWPdsgtqmygf
|..|||| ...|.| .|          ..||||||.. |..... ||||||||..|  ||.||..|.. .||..|.         .. |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

feitlhsmkeypdyilrefkivdsrdaEGSSQHVKQFQYVSWPSKGVPDsAIGLLDVREQVEKwqrnsGDKPIVVHCSGGCGRTGTYIATCLLIDRlkte
                           |   ... |..|..||  ||||    |||  |.|..      ..|..||||.|.|||||..|  |.. .    
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....

GlVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
| |.....|. .| .||||| . .|| |..  .||.|
g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 3247-3471 6.7e-35 115.3 In-house 50-269 (301) alignment 
Range on Protein: 3247-3471
Range on HMM: 50-269/301.0
NRHKNRYANViPfdktrCKLSTIPG--VDGSD-YINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQM
...|.|| .| |     || ||     |||    | ||.|.   . . ||||||||..||.||| |.  ..  .|.||....|  . .|..| | . .. 
pkdkhryptv.P.....ckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

--YGFFEITLHSMKEY--PDYILREFKIVDSRDaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrnsGDKPIVVHCSGGCGRTGTYIATCLL
   | |.|......     . . |.....|| . . ... |  .||..|. .||| | . | |. | | |      .|||||||| | ||. ..|.|  |
ldigrfkikiknkelilnkkiskrtlevedstg.kfatrtvthyqysewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteyl

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQ
  .....  ... . .. || .|   |. . |
areveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 3247-3483 1.7e-28 94.5 In-house 43-271 (288) alignment 
Range on Protein: 3247-3483
Range on HMM: 43-271/288.0
NRHKNRYANVIPFDKTRCKLStipgVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGF
|  ..|| |.   | || |||     |   ||.|| .   .  . .| .| ||  | . .|.|. |     |.||..  | ||    .|.|    .   .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

FEITLHSMKEYpDYILREFKIVDSRDAEG--SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqrNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
  .     |.. . | .  |.   |  .    .. ||.  .  |. .|||.. .  | . | .     .| .||||||.| | ||||| | . . .. |.
grlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 .  . . ...  || .|   ...  || . .. .|| |
lddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 3247-3324 9.7e-10 32.4 In-house 34-110 (332) alignment 
Range on Protein: 3247-3324
Range on HMM: 34-110/332.0
NRHKNRYANVIPFDKTRCKLSTIPGVDgsDYINANFIEGYHKGKAFIATQGPLPDTSD-DFWRMVWEHKSSTIIMLANE
|   ||   .  ||..| .|.   | |  |. ||....|| |  |.| .| |. | ..  ||||| |.| | |... . 
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 3249-3489 8.1e-27 88.7 In-house 45-282 (312) alignment 
Range on Protein: 3249-3489
Range on HMM: 45-282/312.0
HKNRYANVIPFDKTRCKLSTipgvDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDsgtqMYGFFE
  ||| |.  .|. |  |.     |   || |||.    | . |..||||| .|.  ||...    |..||.|.   | |   | ||  |    . || .
dlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd....ivgfvd

ITLHSM-KEYP----------DYI-LREFKIVdsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrnsGDKPIVVHCSGGCGRTGTYIAT
.  | .  ||           | |  | .|.|    | |   .....|. ||| .|.|||    | .   | |       ||.. ||| | ||||| .  
ledhrvyteycteieiggkskdkithrvlkvv..vkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsagvgrtgtlali

CLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
  .|  |.     .| ..   || .|   || . || .. ...|||| |   |
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3249-3355 3.6e-20 67.0 In-house 49-166 (350) alignment 
Range on Protein: 3249-3355
Range on HMM: 49-166/350.0
HKNRYANVIPFDKTRCKLS--------TIPGVDGSDYINANFIEGY----HKGKAF--IATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHK
 |||| |..|....| ||             . ..||||||...      .    |  ||||.||| | |||.... . |   |..|... | .   |..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDSGTQMygfFEITLHSMK
||.. . .    . . | |..
YWqegsydd...itvklaskw
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3249-3339 8.2e-12 39.1 In-house 50-156 (349) alignment 
Range on Protein: 3249-3339
Range on HMM: 50-156/349.0
HKNRYANVIPFDKTRCKLSTI--------------PGVDGSDYINANFIE--GYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMC
 |||| ...|.. .| ||                  .    ||||||...   .   | .|||| ||| | |||....   .   .. | .. | .   |
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDS
..|| . 
diywqel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 3249-3321 1.6e-08 28.4 In-house 39-116 (347) alignment 
Range on Protein: 3249-3321
Range on HMM: 39-116/347.0
HKNRYANVIPFDKTRCKLST-----IPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
 |||  .|   |.||  ||       .  |   ||||  |      | .| || |||||  |||.||   | . .. .
sknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0044763 (Phosphotyrosine protein) phosphatases II 3258-3478 5.2e-33 109.5 In-house 1-166 (178) alignment 
Range on Protein: 3258-3478
Range on HMM: 1-166/178.0
PFDKTRCKLSTIPGVDGSDYINANFIEGYhkgkAFIATQGPlpdtsDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTqmygffeitlhsmkey
|.| || .||...|. .||||||..| ..     ......|      |......|.. ..|..|..| |.|.  |..|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pdyilrefkivdsrdaegssqhvKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGdKPIVVHCSGGCGRTGTYIATCLLIDRlkteGLvDVFQVVRG
                        |.... .|  ||||.   .|.. | .|... ..| .|..|||| | ||.|| .|  |.. .    || ....... 
.......................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRLQRPgMVRSVDQYEFCYKS
.| .|| .| . .|....|. 
vrerRp.ivpnpgqlrqLyef
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3259-3480 1.5e-15 52.1 In-house 30-256 (290) alignment 
Range on Protein: 3259-3480
Range on HMM: 30-256/290.0
FDKTRCKLSTIPGVDGSDYINANFIEgYHKGKAFIATQGPLPDT-------SDDFWRMVWEHKSSTIIMLANEREGGKA----MCHKYWPDSGTQMYGFF
. .||  |        .||| ||..  . .| ..|.|| |. ..         .|| |. . |.  ..|| .  |  .      | || |.|  .   | 
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

EIT--LHSMKEYPDYILREFKIVDSrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEkwqrnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK-
 .|    |. .  | . ||  .      ..    |.  ....| .  |... . ||.. ..|.       . |..|||  |  |  .  |  |    .  
gltvkCkskekeddvetRelvvkfd...deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiae

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSIL
|.| | . .|.  || ||  .. |  .. |    |.
tsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 3272-3393 8.2e-13 42.8 In-house 10-126 (130) alignment 
Range on Protein: 3272-3393
Range on HMM: 10-126/130.0
VDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGgkamcHKYWPDSGTQMYGFFEITLHSM-KEYPDYIlREFKIVDS
..| .||||.|.    . . .. || || ||| |||.|. |     ...|    |       .|||||    .   .|.. .  ..  ..| .  ..  .
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkni.kasnleie

RDAEGSSQHVKQFQYVSWPSKGV
.|   | | .  ||   ||| | 
sdlneshqaltmfqisnwpsdgt
0051429 (Phosphotyrosine protein) phosphatases II 3273-3485 3.3e-51 169.8 In-house 2-227 (272) alignment 
Range on Protein: 3273-3485
Range on HMM: 2-227/272.0
DGSDYINANFIEGYHK---GKAFIATQGPLPDTSDDFWRMvWEHKSSTIIMLANEREGGKAMCHKYWP------------DSGTQMYGFFEITLHSMKEY
. |.||||... ||..    .......|||| | .||||. .|.. .||..| .| | |.  |..|||            .  |  ||.. .||.|.. .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PDYILREFKIVDSRDAEGSsQHVKQFQYVSWPSKGVPDSAigLLDVREQVEKwqrnsgDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVD-------
.||||||. ..   .|. .  .| ...| .||  |||..|  ||.. |.. .      ..|..||||.|..||||..|  ||. ..  |  ||       
ldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
 ....|. || ||||.| . .||.|.|. .||.| |
yleeaveelraqrpgavqteeqylflyeallellrs
0043147 (Phosphotyrosine protein) phosphatases II 3273-3476 5.7e-43 142.0 In-house 3-154 (172) alignment 
Range on Protein: 3273-3476
Range on HMM: 3-154/172.0
DGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEreggkamchkywpdsgtqmygffeitlhsmkeypdyilrefkivdSRD
.|||||||.....|.. . ||||||||. | .|||||..|.. ..|..| ..                                               |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

AEGSSQHVKQFQYVSWPSKGVPdSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIdrlktEGLvDVFQVVRGLRLQRPGMVRSVDQY
.|. .... |..|..||  ||| ..  ||.. |...... .| ..|..||||.|.||||| .|  |..     .|| .....|. .| .|||.| . .||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqy

EFCY
 |.|
rfly
0046846 (Phosphotyrosine protein) phosphatases II 3273-3483 1.6e-41 137.3 In-house 10-173 (176) alignment 
Range on Protein: 3273-3483
Range on HMM: 10-173/176.0
DGSDYINANFIEGYHkgkaFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDsgT--QMYgffeitlhsmkeypdyilrefkivds
 ..||||||.| |..    .||||||||.|  ||..|..|.. .....| .|.| |.  |. |||.       .                          
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

rdaegssqhvkQFQYVSWPSKGVPDSaIGLLDVREQVEKWQRNSgdKPIVVHCSGGCGRTGTYIAtCLlidRLKTEGLVDVFQVVRGLRLQRP-GMVRSV
           |.... ||  ||||.   ||.. |........   .|..||||.|.|||||..| ..    |..|  ..|..... .| ||| |.| . 
...........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlva.ay...llelekglsveealalvreqRplgavqtp

DQYEFCYKSILEFL
.||.|.|. .|..|
eQyrflyefellll
0036282 (Phosphotyrosine protein) phosphatases II 3274-3477 7.7e-51 167.5 In-house 1-164 (174) alignment 
Range on Protein: 3274-3477
Range on HMM: 1-164/174.0
GSDYINANFIEGYHKGKAFIATQGPLPdtsddFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDsgtqmygffeitlhsmkeypdyilrefkivdsrDA
|||||||... ...  . .||.||||.     ||.|..|....|..|| .|.| |. .|. |||.                                 . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

EGSSQHVKQFQYVSWPSKGVPDSAIgLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKtEGLVDVFQVVRGLRLQRPGMVRSVDQYE
|  .... |..|. ||  ||||..| ||.. ..||... .....|..||||.|.||||| .|  |.. .|. |.|||....|| ||||||||| . .||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FCYK
|.|.
flyy
0051082 (Phosphotyrosine protein) phosphatases II 3275-3480 6.3e-36 118.6 In-house 3-150 (151) alignment 
Range on Protein: 3275-3480
Range on HMM: 3-150/151.0
SDYINANFIEGYhkgkaFIATQGPLPdtsdDFWRMVWEHKSSTIIMLANEREGGkaMCHKYWPDSGtqmygffeitlhsmkeypdyilrefkivdsrdae
|||||.....|.     .....|||.    ||.....|.. .||..| .| | |  .|..|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

gssQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrnSGDKPIVVHCSGGCGRTGTYIATCLLIDRlkteglVDVFQVVRGLRLQRPGMVRSVDQYEF
    .|.......||  |.|.|   .|.. |....     ...|..||||.|.||||| .|  |.. .      |....... .||.|||.|.. .|. |
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYKSIL
... .|
qlfall
0049260 (Phosphotyrosine protein) phosphatases II 3282-3477 2.1e-40 133.2 In-house 1-144 (152) alignment 
Range on Protein: 3282-3477
Range on HMM: 1-144/152.0
FIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWpdsgtqmygffeitlhsmkeypdyilrefkivdsrdaegssqhvk
||.||.....|||||||.| | .|||||..|.. .||.|| .. | ||  |..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFQYVSWPSKGVPDSAIGLLDVREQVEKWqRNSGDKPIVVHCSGGCGRTGTYIATCLLIdrlkteGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
|.... ||  ||||... ||.. . .||. . . ..|..||||.|.|||||..|  |..        |.....|. .| .|||.| . .|..|.|.
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3283-3339 1.3e-11 38.5 In-house 229-282 (440) alignment 
Range on Protein: 3283-3339
Range on HMM: 229-282/440.0
IEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREggkAMCHKYWPDS
.||| | .|||||| ||  |  ||||.| ... |||||| .  .     |  |||  
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 3289-3477 9.4e-32 104.8 In-house 3-198 (199) alignment 
Range on Protein: 3289-3477
Range on HMM: 3-198/199.0
G-KAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQY
| . .|||| || .|  |||.||||  |  |.|. ...   .|    |||  .|||  || . .| ...   ||| .  . ....  |  |.. . ..|.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWPSKGVPDSAI--GLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL--KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
 ||  |  |. |.  |..    .| |   .  | |..|||| | | || ..|  . .         .||.|.| . ||  | |.. |...|.| |.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 3290-3477 1.3e-31 104.3 In-house 4-197 (198) alignment 
Range on Protein: 3290-3477
Range on HMM: 4-197/198.0
KAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVS
. .|||| || .|  |||.||||  |  |.|. ...   .|    |||  .|||  || . .| ...   ||| .  . ....  |  |.. . ..|. |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPSKGVPDSAI--GLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL--KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
|  |  |. |.  |..    .| |   .  | |..|||| | | || ..|  . .         .||.|.| . ||  | |.. |...|.| |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 3295-3472 4.9e-16 53.0 In-house 96-277 (302) alignment 
Range on Protein: 3295-3472
Range on HMM: 96-277/302.0
TQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQM--YGFFEITLHSMK----EYP---DYILREFKIVDSRDAEGSSQHVKQFQY
   |  .| . .| .. ... . .. |..  |...  | .|. |   .   .| . ..  |.|    |.    .. |   .| ...  .   . |. ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

VSWPSKGVPDSAIGLLDVREQVEKWQRNsgdkpIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQY
 .|| .| |. |   ||.    | ...|     ..|||| | ||||| .|    |.  ...   |. ..|  .|  | | |.. .| 
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_hpo-7_pd Subfamily hpo-7 3301-3483 1.5e-16 55.1 In-house 45-227 (263) alignment 
Range on Protein: 3301-3483
Range on HMM: 45-227/263.0
DTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGL
.| | |....   |.....||..  | |.  | .|.|    .   . .... . |   | .|.  ...   .     . ||...|. |. |  |  |.  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LDVreqvEKWQRNSgdKPIVVHCSGGCGRTGTYIATCLLID----RLKTE--GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
| .     |  |||  |..||||| | ||.  .  . |.       |.|   . .|  .... || .|.. .    |  |    .|.|.
lni....lkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 3302-3483 4.3e-19 63.6 In-house 40-221 (255) alignment 
Range on Protein: 3302-3483
Range on HMM: 40-221/255.0
TSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLL
| | |....   |.....||..  | |.  |..|.|    .   . .... . |   | .||  .|.         . || ..|  |. |  |. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DVReqveKWQRNSgdKPIVVHCSGGCGRTGTYIATCLLID----RLKTE--GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 .     |  |.|  |..||||| | ||. ... . |.       |.|   . .|  .... || .|.. .    |  |.   .|...
nil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 3362-3480 3.2e-23 77.4 In-house 36-140 (145) alignment 
Range on Protein: 3362-3480
Range on HMM: 36-140/145.0
LrefkivdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSgdKPIVVHCSGGCGRTGTYIATCLLIDrlktEGlVDVFQVVRGLRLQ
|       ... |. .... |..|..||  ||||..  ||.. |..|.....   .|..|||| |.|||||..| .|..     .| |....... .| |
l.......tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsq

RPGMVRSVDQYEFCYKSIL
|||.| ...|..|.|. .|
rpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 3367-3477 1.7e-22 75.1 In-house 48-139 (144) alignment 
Range on Protein: 3367-3477
Range on HMM: 48-139/144.0
IvdsrdaegssqhVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnsGDKPIVVHCSGGCGRTGTYIATCLLIdrlkTEGlVDVFQVVRGLRLQRPGMV
             . |.....||  ||||..  ||.. | .|....   ..|..||||.|.|||||..| .|..    ..| ........ .| .|||.|
e............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgav

RSVDQYEFCYK
 . .|..|...
pnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3376-3488 3.9e-20 66.6 In-house 87-199 (440) alignment 
Range on Protein: 3376-3488
Range on HMM: 87-199/440.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFC
 |. .||..| .|| ||||  |  .| . ..|.. | ..|. |..|||| |.||||  ||   ..   |    .|.| ..  .| .|| ||.. .|| | 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YKSILEFLGSFDT
....|| | . ||
heavlegllcgdt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 3376-3483 4.2e-06 19.6 In-house 203-309 (346) alignment 
Range on Protein: 3376-3483
Range on HMM: 203-309/346.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQV--EKWQRNSGdkpIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYE
 |  ..  ..  |     |  .. .. .  |   ||  .| |   . |    ||||. ..| .   |..|      ....... .. |||| | |  || 
dsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnag...vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqya

FCYKSILEFL
  |  .....
siyaivfdyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3379-3481 3e-12 40.9 In-house 216-342 (350) alignment 
Range on Protein: 3379-3481
Range on HMM: 216-342/350.0
HVKQFQYVSWPSK---GVPDSAIGLLDVREQ------VEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLID-------------RLK--TEgLVD-VFQ
 | |.|.  |.       | | .  |.|...       |..  |.  .||.|||| |.|||||...   |.              .|.  .. . | ...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisi

VVRGLRLQRPGMVRSVDQYEFCYKSILE
.|  || ||  ||...||. |.|...| 
ivnelrkqrismvqnldqfifiYeallf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3379-3483 2.5e-09 30.9 In-house 219-344 (349) alignment 
Range on Protein: 3379-3483
Range on HMM: 219-344/349.0
HVKQFQYVSWPSKGV---PDSAIGLLDVREQV------EKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLID----------RLKTEGL-VD-VFQVVRG
 . |.|.  |.  ..   | | .  |.|....      ...  ..   ...|||| ||||||...   ||..          ..| . |  | .. .|  
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRLQRPGMVRSVDQYEFCYKSILEFL
|| ||  ||. . |. ..|...|...
lrkqrismvqnlaqfiaiyealLkyf
PTPc_DSPc_SM00012 3380-3481 2.3e-32 106.7 In-house 2-105 (105) alignment 
Range on Protein: 3380-3481
Range on HMM: 2-105/105.0
VKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSG-DKPIVVHCSGGCGRTGTYIATCLLIDRLKTE-GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
||...| .|| .|||...  .|.. ..|.|....|.  ||.||||| |.|||||..| ..|...|..| . ||.||.|. || ||||||.. .|| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SILE
 .||
alle
PTEN_1 3383-3462 4.8e-08 28.0 In-house 95-171 (196) alignment 
Range on Protein: 3383-3462
Range on HMM: 95-171/196.0
FQ--YVSWPSKGVPDSAIgLLDVREQVEKW-QRNSGDKPIVVHCSGGCGRTGTyIATCLLIDRLKteglVDVFQVVRGLRLQR
..   ....  |.|. .  |.|. .... | ....  . ..||| .| ||.|| .. ..|. . |     .. . .. .| .|
veylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGt.vvaayLmykgk....ltadeAlelvrekR
0038934 (Phosphotyrosine protein) phosphatases II 3384-3478 5.7e-11 37.9 In-house 81-172 (194) alignment 
Range on Protein: 3384-3478
Range on HMM: 81-172/194.0
QYV--SWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLlIDRLKTeglvDVFQVVRGLRLQRPGMVRSVDQYEFCYKS
.|.   .|..|.. |   ||.  . |... ... .. ..||| .| ||||| .|  | | ||.     .. . .. .|  |||.....|..|  .| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.iyrlgm....saeeAialfrekRpgaipnqdyleallkr
subfamily_PTEN_pd Subfamily PTEN 3401-3454 2.6e-06 22.5 In-house 99-154 (184) alignment 
Range on Protein: 3401-3454
Range on HMM: 99-154/184.0
LDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEG--LVDVFQV
 .. |..|||  .. .. .||||  | ||||. |.. ||  .| ..    ...|. 
eeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfae
subfamily_CG42327_pd Subfamily CG42327 3414-3482 4.3e-15 50.2 In-house 245-314 (319) alignment 
Range on Protein: 3414-3482
Range on HMM: 245-314/319.0
SGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTE-GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
.   |.||||| | ||||. ||. . | .|..    ||. |.|  .| .|   |....|||| || . |.
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_CDC14_pd Subfamily CDC14 3418-3476 2.2e-06 21.7 In-house 265-317 (328) alignment 
Range on Protein: 3418-3476
Range on HMM: 265-317/328.0
PIVVHCSGGCGRTGTYIAtCLLIDRLKteglVDVFQVVRGLRLQRPGMVRSVdQYEFCY
 |.|||  | ||||| || | |. . .    .   ...  ||. |||.| .  | .|..
aiavhCkaGLGrtGtLia.cylmkhyr....ftaaeaiawlricrPGsvigp.qqkfle
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 3419-3482 4.5e-14 46.6 In-house 1-64 (69) alignment 
Range on Protein: 3419-3482
Range on HMM: 1-64/69.0
IVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
.||||| | |||||.||  . . |.|.| |||.|  |. .|  || ||    .| | . .. | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 3420-3483 5.2e-14 46.3 In-house 1-64 (69) alignment 
Range on Protein: 3420-3483
Range on HMM: 1-64/69.0
VVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
||||| | |||||.||  . . |.|.| |||.|  |. .|  || ||   ..| | . .. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_ptpA1_pd Subfamily ptpA1 3449-3481 1.3e-06 22.5 In-house 364-396 (418) alignment 
Range on Protein: 3449-3481
Range on HMM: 364-396/418.0
VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
...| .|  || ||||||. ..|| ||||.||.
fnlfsivlklreqrpgmvqqleqylfcyktild