Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Sponge-PTP2_pd | Subfamily Sponge-PTP2 | 1-109 | 2.5e-77 | 251.4 | In-house | 61-169 (169) | alignment | ||
Range on Protein: 1-109
Range on HMM: 61-169/169.0
MIWETNASVIVVLGDTDDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.|||||||||||||||||
miwetnasvivvlGdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv
GHLFHHSLA
|||||||||
ghlfhhsla
|
|||||||||
subfamily_Sponge-PTP-2_pd | Subfamily Sponge-PTP-2 | 1-108 | 1.1e-76 | 249.4 | In-house | 62-169 (169) | alignment | ||
Range on Protein: 1-108
Range on HMM: 62-169/169.0
MIWETNASVIVVLGDTDDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHV
|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||.|||.|||||||||||||||||
miwetnasvivvlgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhv
GHLFHHSL
||||||||
ghlfhhsl
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 1-188 | 3.2e-22 | 74.7 | In-house | 96-274 (284) | alignment | ||
Range on Protein: 1-188
Range on HMM: 96-274/284.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyD-DDVTEQLSLFHYSTWPQNGVP
|.|| |..|||.| ....... .||...... . . . |.. ... . . . .|.... . .. . .. ||| .|| .|||
mvweqnvrvIVmltelvengrekcaqYwplegevlty..........gdftvtllseevkddytvrtleltnl....gytgesrtvthfhytswpdhgvp
QSPVHVGHLFHHSLAART----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
.|| .. .... ... || |. . .| ||.|.. .. ...|.|. ... .| . .... | |||| | . |. |....| |.|
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd.....vleavkrlreqRpgmvqtleqyrfvyealleyl
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 1-188 | 7.1e-22 | 73.5 | In-house | 127-299 (308) | alignment | ||
Range on Protein: 1-188
Range on HMM: 127-299/308.0
MIWETNASVIVVLGDTDDK-----NNFWPEKED--YQLHpavilgewytDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGV
|.|| | .|||.| ..... .||.... .. . . . |.. ... .. . . ..|. . .. ||| .|| ||
mvweqnvrvIvmLtklvengrekcaqYwplelgggsley..........gkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgv
PQSPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.|| .. ..... . || |. . .| ||.|.. .. ...|.|.. .. . .... | |||| | . |. |..|.| | |
PpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd........vfeavkklReqRpgmvqtpeqylflyralleyl
|
|||||||||
DSPc_SM00195 | 1-186 | 2.1e-20 | 68.5 | In-house | 88-260 (263) | alignment | |||
Range on Protein: 1-186
Range on HMM: 88-260/263.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEdyqlhpaviLGEWYTDSLYVRTDKVHPNTsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.||.. ..||.| . ... ...|||.. |.. ... | . .|. . . . . ... | .. ..| .||..|||.
mvweekvkiivmlteeeengkekcdrywpees.........ggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpd
SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadpNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|. .| .|.. . ||.|... | ||.|.. ....... |.. .. |..... | ||||.| .. |. |..... |
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk........vdifeivkelRkqRpgmvqtleqYlfiyeaile
|
|||||||||
PTPc_SM00194 | 1-186 | 2.1e-20 | 68.5 | In-house | 88-260 (263) | alignment | |||
Range on Protein: 1-186
Range on HMM: 88-260/263.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEdyqlhpaviLGEWYTDSLYVRTDKVHPNTsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.||.. ..||.| . ... ...|||.. |.. ... | . .|. . . . . ... | .. ..| .||..|||.
mvweekvkiivmlteeeengkekcdrywpees.........ggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpd
SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadpNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|. .| .|.. . ||.|... | ||.|.. ....... |.. .. |..... | ||||.| .. |. |..... |
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk........vdifeivkelRkqRpgmvqtleqYlfiyeaile
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 1-187 | 1.2e-19 | 66.3 | In-house | 111-285 (288) | alignment | ||
Range on Protein: 1-187
Range on HMM: 111-285/288.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| | .|||.| ...... .||. .... . . . |.. ... . . . .||. . . |. . . ||| .|| .|||.
mvweqnvrvIvmltklvelgrekcaqYwpl.ggslty..........gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd
SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
|| .. .. .. | . || |. . .| ||.|.. .. ...|.|. .. . .... | ||||.| . |. |....| |.
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd........vleavkrlreqRpgmvqtpeqyrfvyealley
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 1-188 | 2e-19 | 65.4 | In-house | 97-277 (297) | alignment | ||
Range on Protein: 1-188
Range on HMM: 97-277/297.0
MIWETNASVIVVLGDTDDKNN-----FWPEK-EDYQLHpavilgewytDSLYVRTDKVHP--NTSGVEGLFEVSMVihsyDDDVTEQLSLFHYSTWPQNG
|.|| | .|||.| . .... .||.. .... . . . |.. .|. ... . .||... ... . .. ||| .|| .|
mvweqnvtvIvmltelvelgrekcaqywpleegeslty..........gdftvtllsvevvllddytlrtlevtdt....gngesrtvthfhytgwpdhg
VPQSPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
||.|| .. .... . .. || .. . .| ||.|.. .. .....|. . . .| | .... | |||| | . |. |....| | |
vpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd.....ileavkklReqRpgavqtleqyrflyeallell
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 1-186 | 2.3e-19 | 65.3 | In-house | 96-270 (273) | alignment | ||
Range on Protein: 1-186
Range on HMM: 96-270/273.0
MIWETNASVIVVLGDTDDKNN-----FWPEKED--YQLHPAvilgewytdsLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGV
|.|| |..|||.| ....... .||.... .. . . |.. ... .. . . ..... . . ||| .|| .||
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygk..........ftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgv
PQSPVHVGHLFHHSLAART----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|.|. .. ..... |. || |. . .| ||.|.. .. .....|.. .. ...... | |||| | . |. |....| |
ppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd........vleavkllrsqRpgmvqtpeqyrflyealle
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 1-188 | 9.6e-19 | 63.2 | In-house | 105-276 (317) | alignment | ||
Range on Protein: 1-188
Range on HMM: 105-276/317.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . .||| | ...... .||. .... . . . |.. ... .| . . ..|. . .. ||| .|| |||.
mvweqgvtvivmLteleelgrekcaqYwpl.getlty..........gdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp
SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|| .. .... .| . ||... . .| ||.|.. .. ...|.|. .. ...... | |||| | . |. |....| | |
spdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd........veeavkelreqRpgavqtpeqyrflydalleyl
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 1-184 | 4.7e-18 | 60.8 | Pfam-A | 61-233 (235) | alignment | ||
Range on Protein: 1-184
Range on HMM: 61-233/235.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYqlhpavilgEWYTDSLYVRTD---------------KVHPNTSGVeglfevsmvihsydddVTEQL
|.|. . .|||.| . ..| ...|||.|. . ..... |.. ... ... ....
mvwqekvkvivmltsleekgrekcaqYwpeeeee.........sltygdikvelkekekedekeytlrklelkkkkees................ekrev
SLFHYSTWPQNGVPQSPVHVGHLFHHSLAAR--TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadPNIIDsVFRGLLGQRPGLVANQRQFD
. .|| .||..|||.|| .. .| . . ..||.|... .| ||.|.. ..... | |. .. ... . . . | ||||.| . |.
kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.......vdvlq.ivkelRkqRpgmvqsleqYi
FCHRIL
|.....
flykai
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 1-184 | 4.7e-18 | 60.8 | In-house | 61-233 (235) | alignment | ||
Range on Protein: 1-184
Range on HMM: 61-233/235.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYqlhpavilgEWYTDSLYVRTD---------------KVHPNTSGVeglfevsmvihsydddVTEQL
|.|. . .|||.| . ..| ...|||.|. . ..... |.. ... ... ....
mvwqekvkvivmltsleekgrekcaqYwpeeeee.........sltygdikvelkekekedekeytlrklelkkkkees................ekrev
SLFHYSTWPQNGVPQSPVHVGHLFHHSLAAR--TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadPNIIDsVFRGLLGQRPGLVANQRQFD
. .|| .||..|||.|| .. .| . . ..||.|... .| ||.|.. ..... | |. .. ... . . . | ||||.| . |.
kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.......vdvlq.ivkelRkqRpgmvqsleqYi
FCHRIL
|.....
flykai
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 1-185 | 1.4e-17 | 59.6 | In-house | 120-286 (297) | alignment | ||
Range on Protein: 1-185
Range on HMM: 120-286/297.0
MIWETNASVIVVLGDTDDKN----NFWPEKEDyqlhpavilgewYTDSLYVRTDKVHPntsgV----EGLFEVSMvihsydDDVTEQLSLFHYSTWPQNG
|.|| . .||| | ...... .|||... . . . |.. ||. .||.. .. . .. |.| || .|
mvweqgvtvivmLtklvelgrkcaqywpeegg............tygdftvtllkveh....ldgytvrtlevtn......ngesrtvthfqytgwpdhg
VPQSPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILE
||.|. .. .... |. || .. . .| ||.|.. . ..|.|. .. ...... | |||| | . |. |....|
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd........vleavkelreqRpgavqtpsqyrflydall
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 1-189 | 1.5e-17 | 58.0 | In-house | 110-288 (563) | alignment | ||
Range on Protein: 1-189
Range on HMM: 110-288/563.0
MIWETNASVIVVLGD-----TDDKNNFWPEkEDYQLHPAVILGEWYTDSLYVRTDKvhpntsgvegLFEVS-MVIHSYDD-DVTEQLSLFHYSTWPQNGV
|||| |...||.. . . . .||. .. . |. . . .. | . | . . . . .. .. | . .||..||. ||
miWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvr..........tlviknlklkkkkqcdteklvrqyhytkWPdhgv
PQSPVHVGHLFHHSLAARTR--GPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPqsfdadpNIIdSVFRGLLGQRPGLVANQRQFDFCHRILEECLW
|.... | ..| ||. . ||.|. .|.||.| | |.. . .. .. |. . . . ||. ||... |. | | .| |..
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenav.......nvf.gflkhiraqRnflvqteEqYiflhdalleaia
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 1-186 | 3.4e-17 | 58.6 | In-house | 126-302 (307) | alignment | ||
Range on Protein: 1-186
Range on HMM: 126-302/307.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHPAvilgewytdsLYVRTDKVHPntsgVEGLFEVSMVIHSY-DDDVTEQLSLFHYSTWPQNGVP
|.|| . .||| | ....... .||...... . . |.. ... .|. . .. . .. . .. ||| .|| |||
mlweqgvtvivmltelvelgrekcaqywPdegeeltygn..........ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp
QSPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
.|. .. .... ..|. || .. . .| ||.|.. . .....|. | . .| ...... | |||| | |. |. |....| |
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.....lleavkllreqRpgavqnpeqyrflyealle
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 1-185 | 6.1e-17 | 57.4 | In-house | 107-274 (278) | alignment | ||
Range on Protein: 1-185
Range on HMM: 107-274/278.0
MIWETNASVIVVLGDTDDKN-----NFWPekEDYQLHPAvilgewytdsLYVRTDKVHPNTSGVEGLFEVSMvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . ..||.| . .... .|| .... . . |.. |.. . . .||.. . |. . . .|| || .|||
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygd..........ftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpe
SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILE
|. .. .. . . | ||... . .| ||.|.. .. ...|.|. .. ...... | |||| | .. |. |....|
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd........leeavkelreqRpgavqtpsqyrflyeall
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 1-188 | 1.1e-16 | 55.7 | In-house | 110-281 (564) | alignment | ||
Range on Protein: 1-188
Range on HMM: 110-281/564.0
MIWETNASVIVVLGDTDDKNN-----FWPEK--EDYQLHPAVILGEWYTDSLYVRTDKVHPNTsgveglfevsmvihsydDDVTEQLSLFHYSTWPQNGV
|.|| | |.|| | . .|.. .|||| | |. . | .|| |.. .. .. . . ||. ||..||
mvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk.................ssesreVrqFhFtsWPdhgv
PQSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.|. .. .| ... |. ...||.|. | || |.. |... | .. . | | .. . | ||. .| .. |. |.|... | |
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike...ektvD.....iyqyvkalrkqRnamVqteeQYiFiheaileal
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 1-186 | 6.8e-16 | 54.1 | In-house | 73-244 (249) | alignment | ||
Range on Protein: 1-186
Range on HMM: 73-244/249.0
MIWETNASVIVVLGDTDDK-----NNFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . .||| | ... . .||. .... . . . |.. .|. . . . .|.... |. . . ..| || |||.
mlwelgitvivmLtslvelgrekcaqywpl.ggsley..........gdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvpp
SPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|. .. ... . |. . ||... . .| ||.|.. . ..|.|. . ...... | |||| | |. |. |....| |
sfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd........leeavkllrsqRpgavqnpeqyrflyealle
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 1-184 | 1.6e-15 | 52.7 | In-house | 71-239 (245) | alignment | ||
Range on Protein: 1-184
Range on HMM: 71-239/245.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . ..|| | ...... .||. .... . . . |.. ... . . . .||... || . . .|| || .|||
mlwelgittivmLteeeelgrvkcaqywpl.geslty..........gdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpd
SPVHVGHLFHHSLAAR---TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRIL
.. .. ... . |. ||... . .| ||.|.. .. ..|.|. . ...... | |||| | .. |. |....|
llellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs........leeavkelrsqRpgavqtpsqyrflyeal
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 1-192 | 2.6e-15 | 51.6 | In-house | 123-296 (319) | alignment | ||
Range on Protein: 1-192
Range on HMM: 123-296/319.0
MIWETNASVIVVLGdTDDKNNFWPEKEDYQlhpavilgewyTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEQLSLFHYSTWPQNGVPQSPVHV
|||| |.| ||.| | ..|| | . . . |. | |. | .|.| . | .. ||. ||. |||..|. .
miweyncstivllt.kdkcsqywplkivik...........eerfkvkvdsveetaeyvvrdielsedgkekd...irkitqfhflGwpdvGvpdypsdl
GHLFHH--SLAAR--TRGPLVIVSAHGGGRAGCYGVVSVayeLLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHR-ILEECLWGVA
| .. | . | ..|. . | ||.| | |. | ||.. . . | . . |.| ||. || . |. |.. .||| |.| .
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv...lldrmkeekqvd.....vynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 1-192 | 2.7e-15 | 51.6 | In-house | 87-260 (284) | alignment | ||
Range on Protein: 1-192
Range on HMM: 87-260/284.0
MIWETNASVIVVLGdTDDKNNFWPEKEDYQlhpavilgewyTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEQLSLFHYSTWPQNGVPQSPVHV
|||| |.| ||.| | ..|| | . . . |. | |. | .|.| . | .. ||. ||. |||..|...
miweyncstivllt.kdkcsqywplkivik...........eerfkvkvdsveeseeyvvrdielsedgkekd...irkirqfhflgwpdvgvpdypsdl
GHLFHH--SLAA--RTRGPLVIVSAHGGGRAGCYGVVSVayeLLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRI-LEECLWGVA
| .. | . | ..|. . | ||.| | |. | ||.. . . | . . |.| ||. || . |. |.. ||| |.| .
mrlvkkvrhltskenhranivvhcsagvgrtgvyivldv...lldrmkeekqvd.....vynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 1-184 | 2.7e-15 | 52.0 | In-house | 67-238 (243) | alignment | ||
Range on Protein: 1-184
Range on HMM: 67-238/243.0
MIWETNASVIVVLGDTDDKNN-----FWPekedyqlhpavilGEWYTDSLYVRTDKVHPntsgVEGLFEVSMVIHSYD-DDVTEQLSLFHYSTWPQNGVP
|.|| . .||| | ...... .|| ||.. . . |.. ... .. ... .| ||.| . .|| || .|||
mlwelgitvivmltelvElgrekcaqywp.............gevtygdftvtllseeh....lddytvrtlllenldlddltrlvihyhylpwpdhgvP
QSPVHVGHLFHHSL----------AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPdtpqsfdadpniIDSVFRGLLGQRPG-LVANQRQFDFCHRI
.|| .. .... |. . ||... .| ||.|.. . . ..||... ...... | |||| | .. |. |....
dspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvd............leeavkllreqRpgkavqtpsqyrflyea
L
|
l
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 1-186 | 5.7e-15 | 50.9 | In-house | 83-270 (278) | alignment | ||
Range on Protein: 1-186
Range on HMM: 83-270/278.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . .||| | . ... .||| .... . . . |.. ... . . ..| . . |. . . .|| .|| .|||
mlwelgitvivmltelvelgrekcaqywpe.ggslty..........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvps
SP--VHVGHLFHHSLAAR---------------TRGPLVIVSAHGGGRAGCYGVVSVAYELLnmpdtPQSFDadpniIDSVFRGLLGQRPG-LVANQRQF
.| .. .|. ..|. || .. .| ||.|.. .. .||| .. .| ...... | |||| | |. |.
lpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.....eggvd.....lleavkelrsqRpglavqnleqy
DFCHRILEE
|... | |
rflyeflle
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 1-192 | 6.7e-15 | 49.7 | In-house | 105-282 (314) | alignment | ||
Range on Protein: 1-192
Range on HMM: 105-282/314.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDYQLHpavilgewytdsLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDdvTEQLSLFHYSTWPQNGVPQ
.... |.. ||.| . .. ..|||. . . . | ...... | .| |. . ..... . .. |.. .||. .||.
lvydencasivmltelvevgrvkClkyWPedtevygd............ikvelvetellaelvvrifrveklargqee..irevrqfqflgWpdhdvPv
SPVHVGHLFHH--SLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHR-ILEECLWGVA
| . .| .. . . . |..|. |.||.|.. .... .... .. | . . . | ... .| . |. |.. ||| || | .
satgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregv...vd.....vfnavktlrsrkvnmveteeqykfiydvileaclcget
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 1-187 | 3.4e-14 | 47.6 | In-house | 110-282 (319) | alignment | ||
Range on Protein: 1-187
Range on HMM: 110-282/319.0
MIWETNASVIVVLGDTDDKNNFWPEKedyqlhpAVILGEWYTDSLYVRTDKVHPNTSGVEglfEVSMVIHSYDDDV-TEQLSLFHYSTWPQNGVPQSPVH
|.|| ..|..|.| . .| . .| .. . .. | . . ...... . .. ..| | ... |.| ||...||..
mvWeeessivvmltklveklkvklkk.......ywpeenfeeyGrlivtleeeeeledyi...irklklnkkssevetRevkhfqyteWpdhdvPekats
VGHLFHHSLAARTR---GPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFdadpniidSVFRGLLGQRPGLVANQRQFDFCHRILEEC
. .|... .| . ||.|. . | || | . |.... | .. . | |. . | ||. .| .. |. |.. .| |
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf........stvsrlRtqRnimvqrpeqYkfiyeallea
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 1-185 | 7.9e-14 | 46.4 | In-house | 92-265 (274) | alignment | ||
Range on Protein: 1-185
Range on HMM: 92-265/274.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHPAVILGEwytdslyVRTDKVHPNTSgveglFEVSMVIHSYDDDvTEQLSLFHYSTWPQNGVPQ
||......|||.| . ..|. ..|..|||... . | ....|. . ..| .. .| . . .. . |. || . .|.
miyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdve.......ikvekivernd.....ysvrklvlkyler.ersvkhywytdWPdhksPd
SPVHVGHLFHHSLAART-----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfDADPNIIdSVFRGLLGQRPGLVANQRQFDFCHRILE
.. .. .| .. .|. ..| |. . | ||.||. .|.| |. . ... .. | .| |.| .. |... ||.|
dantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.......eivvdvl.kivcnlrldrGGmvqtseqyelihralc
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 1-183 | 9.3e-14 | 45.9 | In-house | 102-275 (288) | alignment | ||
Range on Protein: 1-183
Range on HMM: 102-275/288.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDY-QLHPAvilgewytdsLYVRTDKVHPNtsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVP
|..| .||||.| . .... ..|||... . ... | | .|. | | . .. | | ....|. .. .||. |||
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvret....ethvervlkletldadavksvshlqltsWpelGvP
QSPVHV------GHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDT-PqsfdadpNIIDsVFRGLLGQRPGLVANQRQFDFCHRI
.|| .. . ... ... |||. | ||.| . .| | . |. . . .||. |.. | || | .. |. |. .
asPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll.......diiq.vvsrlreqRrfmvqekeqlkfsyea
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 1-189 | 1.8e-13 | 45.3 | In-house | 108-281 (318) | alignment | ||
Range on Protein: 1-189
Range on HMM: 108-281/318.0
MIWETNASVIVVLGDTDDKN-----NFWPEKedyqlhpavilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| |..|||.| .. .. ..||.| | ..| | .. .. | |.|. . . . | .|| .||..|||.
mvWeqnsavivmltqeeergkakvhryWPsk...........gsrsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpe
SPVHVGHLFHHSLAAR---TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpnIIDSVfRGLLGQRPGLVANQRQFDFCHRILEECLW
|.... .| .. .| ..||.|. . | ||.| . .|.. | .. . . . | . | ||. .| . |..|.. .| | |
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD.......vfqtv.kqlreqrnlmvqtedqyefiydvlleala
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 1-186 | 2.6e-13 | 44.8 | In-house | 110-284 (307) | alignment | ||
Range on Protein: 1-186
Range on HMM: 110-284/307.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHpavilgewytdSLYVRTDKVHPNTSGVEGLFEVSMVI-HSYDDDVTEQLSLFHYSTWPQNGVP
||.| . .||.| . ..||. .||. . | .. |.. . . . .. ..||.. .| . . . .. .|| .|. ||
miaeqevtlivmlsnlteknrkkcakYWpiedevqyg...........dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP
QSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVayeLLNMpdtpQSFDADPNIIDSVfRGLLGQRPGLVANQRQFDFCHRILEE
... . .| .. | |.|.|. | ||.| . ... ||. . . .|.. | ..| ||. || . .|. |..| | .
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds...llqq....lkaedkvdifetv.kdLrsqRnllvqsleqYvflyralld
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 1-188 | 4.2e-13 | 44.2 | In-house | 118-290 (298) | alignment | ||
Range on Protein: 1-188
Range on HMM: 118-290/298.0
MIWETNASVIVVLGDTDDK-----NNFWPEK--EDYQlHPAVilgewytdslyvrtdKVHPNTSgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGV
|..| ....||.| .. .. ...||.. | | . | ... . . | . . ..... . .... .|...||..||
mvteedigtiVmltnleeldktkyhkywPdegketyg.eitv...............sllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgv
PQSPVHVGHLFHHSLA-ARTRG--PLVIVSAHGGGRAGCYGVVsvaYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|. | .| .. | . | |... ..| ||.| . .. . .|. . |. | . | . | .|||.| ..|. |.. . | |
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiai...dsvlervkkeqvvD.....vfqvvkvlRkkrpgavqteeqYvfiyeavleal
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 1-186 | 9.5e-13 | 42.8 | In-house | 117-295 (306) | alignment | ||
Range on Protein: 1-186
Range on HMM: 117-295/306.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYQLHPAVILGEWYTDslyvrtdkvhpntSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|. |. |||.. .. .||..|. . . . . . . | . . .| . ... . .. .|. .||..|||.
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.............sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk
SPVHVGH----LFHHSL--AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpQSFDADPNIIDSVfRGLLGQRPGLVANQRQFDFCHRILEE
.| .| . . ... .... ||.|. . | || | . |. . .|.. . .||| .| ..| . . || ||| . |. | ......
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliek....kgldadidiqklv.ksvreqrsglvqteqqykfvykaikk
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 1-190 | 1.3e-12 | 42.2 | In-house | 120-298 (330) | alignment | ||
Range on Protein: 1-190
Range on HMM: 120-298/330.0
MIWETNASVIVVLGDTDDKNnfwpEKEDYQLHPAVilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHV
|||| ... ||.| . .... |. .| | | . . | ... . | | . .. ... . ... ||. .||. ||| |. .
miweqksativmltelkerk....eekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm
GHLFHH--SLAARTRGPLVIVSAHGGGRAGCYGVVSvayELLNMPDTPQSFDadpnIIDSVfRGLLGQRPGLVANQRQFDFCHRILEEC-LWG
.|... .| .. ||.|. . | ||.| . |.. .|.. . . | . . | . | ||| .| . |. |....| | |.|
lkllkkvkklnqqsagpivvhcsaGvGrtGtfivld...avlervkaerkvd....vfefv.krlrlqrpqmvqtdeqyefiykvlleyylyg
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 1-187 | 1.4e-12 | 42.4 | In-house | 108-282 (305) | alignment | ||
Range on Protein: 1-187
Range on HMM: 108-282/305.0
MIWETNASVIVVLG-----DTDDKNNFWPEKEDYQLHpavilgeWytDSLYVRTDkvhpNTSGVEGLFEVSMVIHS-YDDDVTEQLSLFHYSTWPQNGVP
.|.|. |.|| | . | . .|||.. .. . . ... | ... .....| . | .|. . ... .. .||..|||
liveekvstivmltklveggkdkCrqYWpesktekke.......f..gefsvelk....sektasdyieRklkisiededkesrtvlqyqltdWPdhGvp
QSPVHVGHLFHHSLAARTRG---PLVIVSAHGGGRAGCYGVVSVAYELLNMPDtpqSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
|.. . .|... .. .. ||... | ||.| . .|..| | |. . . | . | . | .|...| .. |..|.| .|.|
qfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEe...vvd.....vfevlkqlRskrmkmvqtldqYvflhdaldel
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 1-188 | 1.6e-12 | 42.3 | In-house | 96-269 (273) | alignment | ||
Range on Protein: 1-188
Range on HMM: 96-269/273.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDYQLHpaviLgewyTDSLYVRTDKVHpntsGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| .|.||... .|. .|||... .| . .. | |. || .|. .. .. . ..... ... .|| |||.
mvweqkaeviamvtlekekgkvkchrywPesknkklk....v....snrlevellkvq....kldgfvvralavkdsesgesrevahlnfvkwPdhgvPs
SPVHVGHLFHHSLAAR-TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDtpqSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.... .. . . .||.|. . | ||.| . .. |. .|.. .|| . . | | || |.| . |. |..... | |
saaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk...efd.....vkeivrklreqrqgvvqtkdqyifvykailevl
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 1-182 | 2.1e-12 | 41.4 | In-house | 90-265 (290) | alignment | ||
Range on Protein: 1-182
Range on HMM: 90-265/290.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDyqlHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEvsmvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| .. .|.| .|. ..||..|. . ...| . ...... . | . | . . | ... ||| ||| |||.
mvWeqkskavvmlnkvvekeqikcaqywPqgee...ekellledtklkvkliseerksyytvrllelen.......lktqetreilhfhyttwpdfgvpe
SPVHVGHLFHHS----LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDADPNIIDsvfrgLLGQRPGLVANQRQFDFCHR
|| ..... .. || || . | ||.| . .| |.. | .| | ... | .| ||. . |..| .
spaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvlle.....lrkyrlGliqtadqlrfsyl
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 1-187 | 4.5e-11 | 37.4 | In-house | 103-275 (281) | alignment | ||
Range on Protein: 1-187
Range on HMM: 103-275/281.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDyqlhpavilgEWYTDSLYVRTDKVHPNTSGVEGLFEVSMvihsyDDDVTEQLSLFHYSTWPQNGVPQ
|.||...|.||.. ... .||... | . |.. . . ... .| |.... .. | ... ..| .||..|||.
mvweqkvsaivmvtreieagklkChrYWPddns..........elkygdvtvkstaeeekatyierkfkler.....esgetreveqlaytaWPdhGvPa
SPVHVGHlFHHSL----AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNmpdtPQSFDADpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
.. .. . |.. . .| |||| . | ||.|.| . . . .. . ..| .. | . | .| .| |..| .... .
ttkelle.frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave....aeleeld...vkavvaelrkernlmvqtvvqyefvykavlda
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 1-187 | 4.6e-11 | 36.9 | In-house | 104-289 (296) | alignment | ||
Range on Protein: 1-187
Range on HMM: 104-289/296.0
MIWETNASVIVVLGDTDDKNN----FWPEKEDYQLHPAVI--LGEWYTDSLYVRTDKVHPNtsgveglfEVSMVIHSYDDDVTE-QLSLFHYSTWPQ-NG
.... ..| .||| .| | .. .||.| | . .. . | | || |. . |.. . . .. . . ||.. .|. .
lvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkk........ivalteqekqvkaetRivklfqlteWeledk
VPQS---PVHVGH---LFHHSL-AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDAdpniidsvFRGLLGQRPGLVANQRQFDFCHRILE
|| | ... . |. . ..||.|.|| |..|.| | . .. ||.. . . |.| . | .||.|| | .. .. .|.
vPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFea........vktlrrsRpqLvenveeYkyiYdvll
EC
|
ea
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 1-183 | 1.3e-10 | 35.5 | In-house | 119-287 (297) | alignment | ||
Range on Protein: 1-183
Range on HMM: 119-287/297.0
MIWETNASVIVVLGDTDD-----KNNFWPEKEDYQLHpavilgeWYTdsLYVRTDKVHPntsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . ||| | .. ...||.. | | . . .... . . |. . . . | .. ||. .||..|||
mvweqGvvvivnltrleeegvkqckrywpdeGsevyh.......iye..vhlvsehiwc.....ddylvrsfylknlqtsetrtvtqfhflswpeegvPa
SPVHVGHlFHHSL--AARTRG-PLVIVSAHGGGRAGCYGVVSVAYEllNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRI
|. . . | . . | | |.|. . .| ||.|.| .. . . .. . | | . | ||||||. . ||.|.
sakslle.frrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln..rllkGvkeid.....iaatlehlrdqrpglvktkdqfefalta
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 1-188 | 2.3e-10 | 35.1 | In-house | 71-242 (250) | alignment | ||
Range on Protein: 1-188
Range on HMM: 71-242/250.0
MIWETNASVIVVLGDTDDKNNFwpekeDYQLHPaVILGEWYTDslyVrtdKVHPNTSGVEGLFEVS-MVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVH
|..| ....||.| . .... | | | | | | | .|.. . . . ... ... .. .. .|. .|| |||.
mvleeksgtivmLtnLkesekt.....yhqywP.vekaekyGd...v...tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevata
VGHLFHHSLAARTR---GPLVIVSAHGGGRAGCYGVVSVayeLLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
| .| .. | . . .|... . | ||.|.. ... .|. . . | . | . | .||. | . |. |...|. . |
vLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida...vlerlkkekvvd.....vfkvikvlrkdrphavesleqyvfvyeiilkal
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 1-185 | 7.8e-10 | 33.3 | In-house | 109-276 (288) | alignment | ||
Range on Protein: 1-185
Range on HMM: 109-276/288.0
MIWETNASVIVVLGDT-----DDKNNFWPEKEDYQLHpavilGewytdSLYVRTDKVHPNTSGVEGLFEVSmvihsyDDDVTEQLSLFHYSTWPQNGVPQ
...|...| || | . ...||.... ... | |. | ... .. |. ... . .. ..| .||..|||.
lvyenktstivmltelveggktkCeeYWPdadkpkny.....G.....svtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPe
SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfdA-DPNiIDSVFRGLLGQRPGLVANQRQFDFCHRILE
| . .| . | . ||.... . | ||.| . .. . . .. . . .. | ||. || ...|. |....|
skapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee........edyiD.vagtvaklRkqRallvqtlkqYefiyevll
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 1-187 | 2.1e-09 | 31.9 | In-house | 113-284 (293) | alignment | ||
Range on Protein: 1-187
Range on HMM: 113-284/293.0
MIWETNASVIVVLGDTDDK-----NNFWPEKedyqlhpavilgewYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSydDDVTEQLSLFHYSTWPQNGVPQ
|.||...|.||.| .. .| ...||.. ... || ... .| .. |. .. .... .|. .||. |||.
mvwekkssiivmltqlvekgkvkCeeYWPad..............eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPe
SPVHVGHL---FHHSL-AARTRGPLVIVSAHGGGRAGCYGVVSvayELLNMPDTpqsfdADPNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
.. . .. ..... . ...|.|. . | ||.| . . .||. .. | | .. | .| || ...|. | |. . .
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald...rllqaiee.....edyvdifgivaelReeRnllvqtekqYifihqcvldl
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 1-193 | 5.5e-09 | 30.0 | In-house | 110-285 (439) | alignment | ||
Range on Protein: 1-193
Range on HMM: 110-285/439.0
MIWETNASVIVVLGDTDDKNNFWPEKEDyqlhpaVilgeWYTDsLYVRTDKVHPNTSGVEGLFEVsmvIHSYDDDVTEQ-LSLFHYSTWPQNGVPQSPVH
...| ... ||.| . . ..|| ... | | | . ||.|. | | | . | |. . ||| .||.. || |
lviekktvtivmltnlvesykywpsdae......v....cygd.iavrvdrnielpnyvirgfkv...fnerdttekertvlqfhyiawpdknvpaqash
VGHLFH---HSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHR-ILEECLWGVAS
| .... . . ||.|. . | ||.| . .| | |.. . | |. . . | || .| . |. | . .||. .| .
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenk...vd.....ikgivkvlrkqrkqmvqalcqyvfiynavledivyGdia
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 1-181 | 3e-08 | 29.1 | In-house | 31-163 (174) | alignment | ||
Range on Protein: 1-181
Range on HMM: 31-163/174.0
MIWETNASVIVVLGDTDDKN-----NFWPEkedyqlhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|..| . ...| | . .. |.||| . .| .. ..| || .|||
mlkelgittvvmlleekelglykcinywpe..............................................lredlerlgiqylylpwpDhgvpd
SPVhVGHLFHHSLAARTR---GPLVIVSAHGGGRAGCYGVVSVAYELLNmpDTPQSFdadpniiDSVFRGLLGQRPGLVANQRQFDFCH
... . ... |. . ||... .| ||.|. . . .| ... ...| | |||| | .. |. |..
lsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvda.......ldlvrelRlqrpgmvqtpsQyrfly
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 1-187 | 3.3e-08 | 27.8 | In-house | 111-278 (315) | alignment | ||
Range on Protein: 1-187
Range on HMM: 111-278/315.0
MIWETNASVIVVLGDTDDKNN-----FWPEKedyqlhpAVILGEWYtdslYVRTDKVHPNTSGVEGLfevSMVihsYDDDVTEqLSLFHYSTWPQNGVPQ
...| . . ||.| .. .... .||.| || |. | .. . . | | |.| ..|.. | . .||..||. |||.
lvfeedigkivmltnlvegekrkaekywpdk.......kviyGkit....vtrkseevnteytvrtl...svv...fgdnire.vvqlhytswpdmgvpk
SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFdadpNiidsVFRGLLGQRPGLVANQRQFDFCHRILEEC
. . . .|. . .| |..|. | ||.| . .. . ... . . | . .|. .| ..|. |..| . .| |
ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy....n....fitgvrqnrikmvqvaeqyqfiydallet
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 1-184 | 8.4e-08 | 26.5 | In-house | 103-272 (280) | alignment | ||
Range on Protein: 1-184
Range on HMM: 103-272/280.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDYQlhpavilgeWYTdSLYVRTDKVHPNTSGVeglfEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| ..|.||.| .. .. ..|||.|| . |. .. |. | . ..| | .|.. . . .. . | ||..|||.
mvweqksslivmlttlverGrvkChqyWPetedel.........eyg.efsvkcekedetksyv....lrelvlkdketkeerkilqlqylaWpdhgvPd
SPVHVGHLFHHSLAAR--TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfdADPNIIDSVFRGLLGQRPGLVANQRQFDF-CHRIL
.. .. .. .. ..| .. |.|. . | ||.| . .. .| |... |.| . . | . || || .. |. | |. ||
dsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea........aepvypldivrtmrdqramlvqtasqykfvCeail
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 1-184 | 2.6e-07 | 24.9 | In-house | 83-260 (270) | alignment | ||
Range on Protein: 1-184
Range on HMM: 83-260/270.0
MIWETNASVIVVLGDTDDKN-----NFWPEkedyqlhpavilgeWYTDSLYVRTDKVHPNT---SGVEGLFEVSMVIHsyDDDVTEQLSLFHYSTWPQNG
||||.... ||.. . .|. .||. ... ... |.. . . || . .. .. ...| |.| |||..|
miweekvtaivmttgleEkgrkkCerYWpa..............epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhg
VPQSPV------HVGHLFHHS---LAARTR-GPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtPQSFDADpNIIDSVFRgllgQRPGLVANQRQFDFCHR
||... .. ..... . .||.. . | ||.|. .. | .||.. .. | .||. . . .|. || .|. | ..
vpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLee...tkkvdvl.aiieelRk....dRmalvqhpeqyeflyk
IL
.
av
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 1-186 | 3.1e-07 | 25.6 | In-house | 53-169 (182) | alignment | ||
Range on Protein: 1-186
Range on HMM: 53-169/182.0
MIWETNASVIVVLGdtddKNNFWPekedyqlhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsydDDVTEQLSLFHYSTWPQNGVPQsPVHV
|..| . ..|| | . || .... . ..| || .||| . ..
mlkelgittivnlt....eelywp.................................................ellerlgiqylylpwpDhgvpd.ldel
GHLFHHSLAarTRGPLVIVSAHGGGRAGCYGVVSVAYELlNMPdtpqsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
.. . |. || .. .| ||.|.. . . ..| ... ...... . .||| | . |. |....| |
ldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.gvs............leeavklvrsrRpgmvitpnqyfflqlalle
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 1-187 | 4.3e-07 | 25.5 | In-house | 113-279 (314) | alignment | ||
Range on Protein: 1-187
Range on HMM: 113-279/314.0
MI--WETNASVIVV---------------------LGDTDDKNNFWPEKEDYQLHpavilgewytdslyvrtdkvhpntsgveglfevsmvI-------H
|. .. | .|| | . | ..|...... .|.
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk....................................eelydpelf
sydddvTEQLSLFHYSTWPQNGVPqSPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpDTPQSFDAdpniidsvfrgLLGQRP--
... ... .| ...| .. .. ..... ..|.. ||... ..| ||.|.. |. ||.. . . .. . .||
......erlgikylripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealed...........vrlkRpin
---GLVANQRQFDFCHRILEEC
|.. ...|. |....|.|
pnpgfieqleqyefilealley
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 1-189 | 1.2e-06 | 22.6 | In-house | 106-279 (315) | alignment | ||
Range on Protein: 1-189
Range on HMM: 106-279/315.0
MIWETNASVIVVLGDTD--DK---NNFWPEKEDYqlhpAVILGewytdSLYVRTDKVHPNTSGVEglfeVSMVIHSYDDdvTEQLSLFHYSTWPQNGVPQ
|....... ||.. . . || ...||... .| .| |. | . .....| || .|. .. ..... |.. ||..||..
mvlqekvttivmvtkkqegdkikcrqywPdrkad....svefG.....sikvellsleadtdgva....rklvtrksee..srtvtqfqftewPdkGvdk
SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAgcyGVVSVAYELLNMPDTPQSFDadpnIIDSVfRGLLGQRPGLVANQRQFDFCHRIL-EECLW
. .| . | . .|.. . | ||. ||| . | .. .| | . . | . | .|| || . .. | . .. |. ||
qtssllklikevkadngkkefsllvhcsaGvGrt...Gvvisidevvaqikrtrsvd....vfnfv.knlrakrpylvqteeeyafiydavledllw
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 1-184 | 1.8e-06 | 23.3 | In-house | 42-169 (176) | alignment | ||
Range on Protein: 1-184
Range on HMM: 42-169/176.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYQLhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsydddvteqlsLFHYSTWPQNGVPQ
|..| . ...| | . .. |.||| |.... ... || .|||.
mlkelgitavvnlteevelgrlkcpnywpeleklgi..................................................qylhlpwpDhgvpd
SpVHVGHLFHHSLAARTRG-PLVIVSAHGGGRAGCYGVvsvAYeLLNMpdtpqSFD--AdpniiDSVFRGLLGQRP-GLVANQRQFDFCHRIL
. .. .|. |...| | .. .| ||.|.. . || || ... . . ... . ||| | | .. | |... .
l.elllellefirealkeggpvlVHCsaGigRtgtlva...ay.llel.....ekglsv.....eealalvreqRplgavqtpeQyrflyefe
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 1-138 | 2.5e-06 | 21.4 | In-house | 104-251 (301) | alignment | ||
Range on Protein: 1-138
Range on HMM: 104-251/301.0
MIWETNASVIVVLGDTDDK-----NNFWPE--KEDYQLHPA-VILG-EWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddVTEQLSLFHYSTWPQN
.||. . ||.. ..... ...||. .|... | | | | . .| .|. . . .| .| .. ..| . .. .. |||.
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqd
GV---PQSPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYE
|| |. ..| . | ||.|. . .|.| | ||.. |
GvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglE
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 3-191 | 1.1e-10 | 37.1 | In-house | 42-228 (272) | alignment | ||
Range on Protein: 3-191
Range on HMM: 42-228/272.0
WETNASVIVVLGDTD--DKNNFWPEKEDYQLHPAVILGEWYTDSLYVR-TDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPvh
.| . ..|| | ... ........ .. ... ||.. ... || . . ... . . . .... .. . . .. ..|| || ||||..
kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..
VGHLFHHSLAartRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDADPNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEECLWGV
. .|... |. ||... ..| .| |.. .. .. ... . . . .. . . | |||| | .. |. |....| | | ..
llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 32-185 | 2.3e-07 | 26.1 | In-house | 3-140 (145) | alignment | ||
Range on Protein: 32-185
Range on HMM: 3-140/145.0
HPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVsmviHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHSLAARTRG-PLVIVSAHGGGRAGCY
|. ||. .| ||.. | . |. .. . |. ...... ..| || .|||... .. .... .|. .| | .. .| ||.|..
wpseilpglylgslptaldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl
GVVSVAYEllnmpdtpqsF--DadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILE
. . .. . . ...... . |||| | |. |. |... ..
vaaylmll..........lgvs.....leealelvrsqrpgavpnpgqlrflyefel
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 36-182 | 6.7e-06 | 21.4 | In-house | 7-139 (144) | alignment | ||
Range on Protein: 36-182
Range on HMM: 7-139/144.0
ILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMviHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHSLAA-RTRGPLVIVSAHGGGRAGCYGVVS
||. .| ||.. | . |. .. .. . . .... . ... || .|||... .. .... .| . || .. .| ||.|.. .
ilpglylgslptaldlellkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay
VAYellnmpdtpqSFDADpniIDSVFRGLLGQRPGLVANQRQFDFCHR
. . .. . ...... . .||| | |. |. |...
lmk..........klgls...leealalvrsrrpgavpnpgqlrfLle
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 55-186 | 1.8e-08 | 28.8 | In-house | 148-269 (288) | alignment | ||
Range on Protein: 55-186
Range on HMM: 148-269/288.0
NTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHSlaARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpn
. .... | .||.. | . . . |. |...|||.. . .| . .. |.|. | .| ||.| .. .| | | ..|
kradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrlddflg.......
iIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
| |.. | .| . . |. . ||.. |
.irsllaklreerfkaiqtemqylyvhrcvle
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 59-188 | 4e-06 | 20.4 | In-house | 69-194 (440) | alignment | ||
Range on Protein: 59-188
Range on HMM: 69-194/440.0
VEGLFEVSMVIHSYDDDV-TEQLSLFHYSTWPQNGVPQSPVHVGHLFH---HSLAARTRGPLVIVSAHGGGRAGCygvVSVAYELLNMPDTPQSFDadpn
|.|. . . || . . . | .|| ||..|||. | .. . .| |||.. .. | ||.| . . .| . |
vkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgv...iiavdsilreakrsdqid....
iIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
| |. . .|| .| |. | | . | |
.ifsfinsmrnnrpqmvqtpeqyafvheavlegl
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 64-184 | 1.7e-06 | 21.9 | In-house | 174-285 (305) | alignment | ||
Range on Protein: 64-184
Range on HMM: 174-285/305.0
EVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPqsPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCygVVSVAYELLNMPDTPQSfDADPNIIdsvfRGL
..... .| | . . .... ||. ||| |... | | .. |.|. . | ||.| .|.. | | .. . . |... . |
qitllnltysgdqkmsvrhlqwtewpdrgvp..pckltslellsairgskvpivvhcsagigrtgt..ivaieyilekiaenkpc.ppmpelv....kal
LGQRPGLVANQRQFDFCHRIL
|| . |. |. | ||..
rdqrafsiqndvqylfihrvm
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 73-188 | 5.9e-06 | 20.6 | In-house | 173-288 (325) | alignment | ||
Range on Protein: 73-188
Range on HMM: 173-288/325.0
DDDVTEQLSLFHYSTWPQNGVPQSPVHVG------HLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYEllNMpDTpqsfDADPNIIDSVFRgLL
.. | . |.. .|.. ||.. | . . . . | .. .|... . | ||.| . . | . .. . .. .| ..| . |
kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysala..kv.ie....esrvdifgfvkk.lr
GQRPGLVANQRQFDFCHRILEECL
.|| .| |. ... | | .
kdrpsmvetvdqyiliyealveay
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 75-186 | 2.3e-12 | 41.4 | In-house | 167-275 (290) | alignment | ||
Range on Protein: 75-186
Range on HMM: 167-275/290.0
DVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVA
. . .. ||| || |||.|. .. .| .. | . |||. . | ||.| .. ..|||. .|...| . .. . | ||. ||
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeld.....vfdlvlelrkqraalvq
NQRQFDFCHRILEE
. |. . .. ..|
tkeqyelvykavae
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 77-184 | 1.2e-06 | 22.5 | In-house | 185-283 (305) | alignment | ||
Range on Protein: 77-184
Range on HMM: 185-283/305.0
TEQLSLFHYSTWPQNGVPQSPVHVGHLFHHslAARTRGPLVIVSAHGGGRAGCygVVSVAYELLNMPdTPQSFDADPNIIDSVfrglLGQRPGLVANQRQ
... . .|. ||. ||| . . . |... | ..||.|. . | ||.| || . | | .. . | . |. . || . ..|
arkvthyhwidwpdrgvpaadlailellek..arpskgpivvhcsagigrtgs..vvmleyildqll.agqiiedtdkilqki....reqrnnsiqtdaq
FDFCHRIL
. | |...
ylfvhqvi
|
|||||||||
PTPc_DSPc_SM00012 | 81-184 | 8.9e-14 | 46.9 | In-house | 3-103 (105) | alignment | |||
Range on Protein: 81-184
Range on HMM: 3-103/105.0
SLFHYSTWPQNGVPQSPVHVGHLFHHSLAART----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDtpqsfdaDPNIIDSVFRGLLGQRPGLVANQRQ
. .||..||. |||... .. .|... .. ..|.|... .| ||.|.. ....... |. . | ... | ||||.| ...|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.......kevdifqivkelrkqRpgmvqteeq
FDFCHRIL
. |..|.|
ylflyral
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 82-184 | 2.6e-08 | 27.6 | In-house | 185-281 (302) | alignment | ||
Range on Protein: 82-184
Range on HMM: 185-281/302.0
LFHYSTWPQNGVPQSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfDADPNIIDsVFRGLLGQRPGLVANQRQFDF
. . . |.|. ||.. .. . .. . . . ..|||| .| |||| .. || | |. ...||| . . . . ||| | . |. .
vyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqk.......gkepnike.ivksiRsqRpravdslkQyvs
CHRIL
...|
lyial
|