Gene AquePTP-Un-6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP147_AA protein Get Run
AqueP147_AA_65-309 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRA_pd Subfamily PTPRA 59-144 3.6e-12 40.8 In-house 10-98 (330) alignment
Range on Protein: 59-144
Range on HMM: 10-98/330.0
KLSPVELTALEYEVSR--LQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQGSQ
|  |. .  || |. .   .| .  .|||  |   . .     |    |  |||..||||.| .|||||  . .| |||||| .|.| .
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk

subfamily_PTPRD_pd Subfamily PTPRD 62-142 5.6e-17 56.6 In-house 4-86 (564) alignment
Range on Protein: 62-142
Range on HMM: 4-86/564.0
PVELTALEYEVSRLQ--DEEVAKEEFVGLSDHtREFLQTNAVLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQG
|.. ..|.  | .|.  ..   .||.  .. . ..|  ..|  .||  |||| ||...|..||.||. . .||||||||..|.|
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidg

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 62-146 1.5e-12 42.3 In-house 9-94 (297) alignment
Range on Protein: 62-146
Range on HMM: 9-94/297.0
PVELTALEYEVSRLQDEEVAKEEFVGLsDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKE-GSDYINANYIQGSQN-I
|. |. .   | . .. .| .|||  |  ..  . || |    |  |.|| ||||.|  ||.| .  ..  |||.|| ...| .. .
piplsdfatlvqknrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 64-144 6.3e-18 59.9 In-house 3-86 (318) alignment
Range on Protein: 64-144
Range on HMM: 3-86/318.0
ELTALEYEVSRLQDE--EVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQ
.. .||  | ||. .   . .||.  || ..... ..... ..|..||||.|||..|.||| |.   ..|||||||||||.| .
svedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 66-149 1.9e-24 80.4 In-house 1-109 (130) alignment
Range on Protein: 66-149
Range on HMM: 1-109/130.0
TALEYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATK------NRYINIL-----------------PFD--ETRVILSSSKKEGSDYINANYI
.|||.||||||........||||...|.|.|.|...|......      .||.|.|                 |..  |...|...........|.|...
aalefevsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdrdefknikasnl

QGSQNIIRP
........ 
eiesdlnes

0039614 (Phosphotyrosine protein) phosphatases II 66-145 2e-13 46.0 In-house 19-98 (297) alignment
Range on Protein: 66-145
Range on HMM: 19-98/297.0
TALEYEVSRLQDEEVAKEEFVGLSDHTREflQTNAVLSANATKNRYINILPFDETRVILSSSKK--EGSDYINANYIQGSQN
 .| . . .. .  . ..||  | . . .  .. | | .| .||||..|||.| .||.|.. ..  ..||||||.|..|   
ldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 67-310 1.5e-175 575.5 In-house 1-244 (244) alignment
Range on Protein: 67-310
Range on HMM: 1-244/244.0
ALEYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQGSQNIIRPDPSVMKDAFNPNNSWKN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
aleyevsrlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswkn

REGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEPLEWYEEDITVTLTDRDE
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
regaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvtltdrde

FKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPNDHFIMV
||||||||||||||||||||||||||||||||||||||||||||
fknikasnleiesdmneshqaltmfqisnwpsdgttpndhfimv

subfamily_PTPRB_pd Subfamily PTPRB 67-144 2.7e-14 47.9 In-house 11-91 (293) alignment
Range on Protein: 67-144
Range on HMM: 11-91/293.0
ALEYEVSRLQD--EEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQ
 .|  |....   .   .||.  |..  ..  .. | |..|..|||| ||||.|..|| | . ....||||||||||.| .
kfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn

0050432 (Phosphotyrosine protein) phosphatases II 68-143 4.6e-15 51.2 In-house 31-102 (308) alignment
Range on Protein: 68-143
Range on HMM: 31-102/308.0
LEYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILssskKEGSDYINANYIQGS
| . . .. |    .|||  | . .  .  . | | .| .|||| .|||.| .||.|    .||||||||.|..| 
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgy

0045450 (Phosphotyrosine protein) phosphatases II 68-140 1.4e-13 46.7 In-house 16-92 (307) alignment
Range on Protein: 68-140
Range on HMM: 16-92/307.0
LEYEVSRLQDEEVAKEEFVGLSDHTR--EFLQTNAVLSANATKNRYINILPFDETRVILSSSKK--EGSDYINANYI
|.. .  | . .  ..||  | . |    .  . | | .| .|||| .|||.| |||.||| ..  |.||||||.|.
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyv

subfamily_PTPRN_pd Subfamily PTPRN 68-141 2.1e-06 21.7 In-house 18-93 (297) alignment
Range on Protein: 68-141
Range on HMM: 18-93/297.0
LEYEVSRLQDEEVAKEEFVGLSDHTREFLQT-NAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQ
|.|    |....  ..|. .| ..  |   .  |    |..|||. ..||.|..|| |.. ...| ||||||  | 
lsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail

subfamily_Ptp69D_pd Subfamily Ptp69D 69-145 2.5e-12 41.5 In-house 12-89 (307) alignment
Range on Protein: 69-145
Range on HMM: 12-89/307.0
EYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQN
...... . ..  ..|.  |  .. .   ...    || |||| .| .||.|||.|.    || ||||||..|.| ..
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke

0047943 (Phosphotyrosine protein) phosphatases II 73-142 3.5e-14 48.4 In-house 6-72 (273) alignment
Range on Protein: 73-142
Range on HMM: 6-72/273.0
SRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILsssKKEGSDYINANYIQG
 .| .  . .|||  | . . ..  . |.| .| .|||| .|||.| .||.|   . .|||||||.|..|
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdg

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 73-142 2.5e-10 35.0 In-house 17-86 (325) alignment
Range on Protein: 73-142
Range on HMM: 17-86/325.0
SRLQDEEVAKEEFvGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEG-SDYINANYIQG
 . ||..    || ||        .. |.. .|  |||. |....|..||.| . |... ||||||.|.. 
kkaqdqdgfahef.gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrd

0051299 (Phosphotyrosine protein) phosphatases II 75-142 5.9e-15 50.9 In-house 19-87 (288) alignment
Range on Protein: 75-142
Range on HMM: 19-87/288.0
LQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQG
. .    .|||  | . .  . .. |.| .| .|||| .|||.| .||.||. .. ||||||||.||.|
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg

subfamily_PTPN14_pd Subfamily PTPN14 75-141 6.7e-09 30.1 In-house 20-85 (300) alignment
Range on Protein: 75-141
Range on HMM: 20-85/300.0
LQDEEVAkEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQ
|.. .|   |.  .. .  . | . | |  || |||. ..||....|| ||..|.. ..||||  |.
leegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassik

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 76-145 8.8e-08 26.3 In-house 17-89 (290) alignment
Range on Protein: 76-145
Range on HMM: 17-89/290.0
QDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILS--SSKKE-GSDYINANYIQGSQN
. .|  ...|  |    .|.  | .. | | ..||. ||.. |. |..|   |..|.   .|||| ||.| ..
kgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 77-144 9.5e-13 42.9 In-house 21-88 (319) alignment
Range on Protein: 77-144
Range on HMM: 21-88/319.0
DEEVAKEEFVGLSDHTREfLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQ
 |   ..||  |.  . .   ..|    | .|||| |||..| |||.||.   .||||||||..|.| |
getllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq

subfamily_PTPN13_pd Subfamily PTPN13 77-141 1.3e-09 32.8 In-house 9-69 (273) alignment
Range on Protein: 77-141
Range on HMM: 9-69/273.0
DEEVAKEEFVGLSDhTREFLQTNAVLS-ANATKNRYINILPFDETRVILSSSKKegsdYINANYIQ
|..  .|||  | .  .  ....   . .| .|||| |.||.|||||.|...      ||||..|.
dqqqPaeefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslik

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 78-144 7.4e-07 23.6 In-house 21-86 (305) alignment
Range on Protein: 78-144
Range on HMM: 21-86/305.0
EEVAKEEFVGLSDHtREFLQTNaVLSANATKNRYINILPFDETRVILSSSKKEG-SDYINANYIQGSQ
..  ....  | ..  | .. .   .||..|||. .| ..|. |.||. ..... ||||||.|..| .
dkgleaqykslyee.eesidvg.kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 78-143 4.4e-06 20.4 In-house 19-87 (439) alignment
Range on Protein: 78-143
Range on HMM: 19-87/439.0
EEVAKEEFVGLSDHTREF--LQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGS
.|. ||.|  ..    ..    . |  . . ||||| .. .|| |||.|        | |||||||.| 
qeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGy

0040438 (Phosphotyrosine protein) phosphatases II 79-144 2.9e-13 45.2 In-house 18-83 (317) alignment
Range on Protein: 79-144
Range on HMM: 18-83/317.0
EVAKEEFVGLSDHTREfLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQ
 . .|||  | . . .   . | | .|  |||| .|||.| .||.||. .. ..||||||.|..| .
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpn

0043336 (Phosphotyrosine protein) phosphatases II 79-144 1.7e-12 42.8 In-house 20-85 (278) alignment
Range on Protein: 79-144
Range on HMM: 20-85/278.0
EVAKEEFVGLSDHTReFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGSQ
 . ..||  | . .  . .. | | .| .|||| .|||.| .||.||. .. ..||||||.|. | .
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgyn

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 79-143 3.7e-11 37.7 In-house 15-80 (281) alignment
Range on Protein: 79-143
Range on HMM: 15-80/281.0
EVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILS-SSKKEGSDYINANYIQGS
.  .||. .|..  ..   | .   .| .||||.||  .| ||| .. ..... .||||||...| 
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 80-144 1.1e-09 32.6 In-house 20-84 (315) alignment
Range on Protein: 80-144
Range on HMM: 20-84/315.0
VAKEEFVGLSDHTrEFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQ
.  |||  | |    . |. |  . | .|||| ||||.|..||.|    ..  |||||| ||.. .
lfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd

subfamily_PTPN6_pd Subfamily PTPN6 81-144 2.6e-15 51.2 In-house 28-93 (306) alignment
Range on Protein: 81-144
Range on HMM: 28-93/306.0
AKEEFVGL--SDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQGSQ
 .|||  |  ..... . ....    |..|||| ||||||.|||||....  ||||||||||....
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkev

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 81-144 8.7e-14 46.2 In-house 23-87 (288) alignment
Range on Protein: 81-144
Range on HMM: 23-87/288.0
AKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGSQ
 .||.  |.   ..  .| . |. ||.|||| ||||.||.|| |    ...|.|||||.||.|..
fseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek

0036941 (Phosphotyrosine protein) phosphatases II 81-144 2.2e-13 45.6 In-house 15-75 (297) alignment
Range on Protein: 81-144
Range on HMM: 15-75/297.0
AKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILsssKKEGSDYINANYIQGSQ
 ..||  | ..   .  . | | .| .|||| .|||.| |||.|   ..||||||||.|..| .
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgyd

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 81-145 9e-09 29.2 In-house 22-86 (392) alignment
Range on Protein: 81-145
Range on HMM: 22-86/392.0
AKEEFVGLSDHTrEFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQN
  |||  | .    . || |    |  |||| ||||.|..||.|        |||.|| ||.. .|
ffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn

subfamily_ptpA1_pd Subfamily ptpA1 82-143 2.2e-10 34.8 In-house 24-86 (418) alignment
Range on Protein: 82-143
Range on HMM: 24-86/418.0
KEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGS
||||  | .       ..     |..|||| |||| . ||| |     ||||||||||||.|.
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 82-145 1.1e-09 32.0 In-house 21-84 (515) alignment
Range on Protein: 82-145
Range on HMM: 21-84/515.0
KEEFVGLSDhTREFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQN
 |||  |      . || |    | .|||| ||||.| .||.|     .  |||.|| ||.. .|
seefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 82-144 9e-09 29.7 In-house 23-83 (287) alignment
Range on Protein: 82-144
Range on HMM: 23-83/287.0
KEEFVGLSD-HTREFLQTNAVLSANATKNRYINILPFDETRVILSsskKEGSDYINANYIQGSQ
|. |. | .   ||   | .. | |  |||. .||. |. ||.|    .|  ||||| .|.| .
knqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgyk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 82-144 1.1e-07 26.2 In-house 19-79 (307) alignment
Range on Protein: 82-144
Range on HMM: 19-79/307.0
KEEFVGLSDHTREFLQTNAvLSANATKNRYINILPFDETRVILSSSkKEGSDYINANYIQGSQ
..||  |...| | ....| .|||. |||| ..   | .|...  .    |||| |||.  . 
vdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvkfd.glasdyihanylgiai

subfamily_PTPN9_pd Subfamily PTPN9 83-144 1.7e-10 35.4 In-house 20-82 (297) alignment
Range on Protein: 83-144
Range on HMM: 20-82/297.0
EEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQ
.|.. . ... |   ... | || .|||| ..| .||||| |..  ..| |||||||...| .
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk

subfamily_PTPN1_pd Subfamily PTPN1 83-141 1.2e-07 25.7 In-house 10-65 (290) alignment
Range on Protein: 83-141
Range on HMM: 10-65/290.0
EEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKegsDYINANYIQ
| .  .......| ...| | .| ..||| .. |.| .|..| ....   |||||. ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslve

DSPc_SM00195 84-143 4.4e-14 47.8 In-house 5-65 (263) alignment
Range on Protein: 84-143
Range on HMM: 5-65/263.0
EFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGS
||  | . | .   |.|  ..| .|||| ||||.|.|||.|....| |||||||||||.|.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga

PTPc_SM00194 84-143 4.4e-14 47.8 In-house 5-65 (263) alignment
Range on Protein: 84-143
Range on HMM: 5-65/263.0
EFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGS
||  | . | .   |.|  ..| .|||| ||||.|.|||.|....| |||||||||||.|.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 84-145 1.4e-11 39.2 In-house 32-97 (298) alignment
Range on Protein: 84-145
Range on HMM: 32-97/298.0
EFVGLSDHTR---EFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGSQN
||  |.  .    |. .. |  ..|  |||| .|...| .||.|.. ...| |||||| .... ..
efqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykg

0046845 (Phosphotyrosine protein) phosphatases II 91-143 5.1e-14 47.8 In-house 12-68 (284) alignment
Range on Protein: 91-143
Range on HMM: 12-68/284.0
HTREF--LQTNAVLSANATKNRYINILPFDETRVILSSSKK--EGSDYINANYIQGS
 |  .    . |.| .| .|||| .|||.| .||.|.| ..  |.||||||.|..| 
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgy

subfamily_PTPN12_pd Subfamily PTPN12 94-145 1.3e-12 42.2 In-house 29-81 (290) alignment
Range on Protein: 94-145
Range on HMM: 29-81/290.0
EFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQN
.. ....  . | .|||| .|||.|..|| ||  .. |||||||||.|.|...
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 94-301 1.5e-08 27.8 In-house 16-154 (169) alignment
Range on Protein: 94-301
Range on HMM: 16-154/169.0
EFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINAnyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyin
|. .  | |..| ||||    |    ||| |    .. |||||||                                                       
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina.......................................................

asfvgclgrtaeyiltqhpladtsmdfwKMMLERHVNVLVVLGSVEEEDEYWPDSEPL---------EWYEEDITVTlTDRDEFKN-----IKASNLEIE
                            .|. |    |.||||  .. ...||. |           ||| . . |  ||. . .      .   .. | 
............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilgewytdslyvr.tdkvhantsgveglfevsmvih

SDMNESHQALTMFQISNWPSDGT
|  ..  . |.... | || .| 
sydddvteklsllhystwpqngv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 94-301 1.9e-08 27.3 In-house 15-153 (169) alignment
Range on Protein: 94-301
Range on HMM: 15-153/169.0
EFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINAnyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyin
|. .  | |..| ||||    |    ||| |    .. |||||||                                                       
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina.......................................................

asfvgclgrtaeyiltqhpladtsmdfwKMMLERHVNVLVVLGSVEEEDEYWPDSEPL---------EWYEEDITVTlTDRDE-----FKNIKASNLEIE
                            .|. |    |.||||  .. ...||. |           ||| . . |  ||. .      . .    | |.
............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilGewytdslyvr.tdkvhpntsgveglfevslvih

SDMNESHQALTMFQISNWPSDGT
|  ..  . |.... | || .| 
sydddvteqlsllhystwpqngv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 95-144 6.8e-13 43.0 In-house 28-77 (287) alignment
Range on Protein: 95-144
Range on HMM: 28-77/287.0
FLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQGSQ
..  .|   |.. |||| ..||.|.|||.||   . |||||||||. . .
atfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasyt

subfamily_PTPN3_pd Subfamily PTPN3 95-141 6.2e-11 36.7 In-house 31-74 (280) alignment
Range on Protein: 95-141
Range on HMM: 31-74/280.0
FLQTNAVLSANATKNRYINILPFDETRVILSSSKKegsDYINANYIQ
   ..| ...|..|||| .|||.|.|||.|..|..   |||||||..
laisaarkpenlsknryrdilpydatrvklkeset...dyinanyvn

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 96-145 1.5e-10 35.7 In-house 19-70 (274) alignment
Range on Protein: 96-145
Range on HMM: 19-70/274.0
LQTNAVLSANATKNRYINILPFDETRVILS--SSKKEGSDYINANYIQGSQN
 | .  .. ..||||| .||| ...||.|.  ||..| |.|||||||.| ..
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyde

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 97-145 1.6e-11 39.1 In-house 53-102 (319) alignment
Range on Protein: 97-145
Range on HMM: 53-102/319.0
QTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQN
|| | |  |  |||.||||.||...| |     .|.|||||| ...| |.
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 97-145 2.7e-11 38.5 In-house 17-66 (284) alignment
Range on Protein: 97-145
Range on HMM: 17-66/284.0
QTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQN
|| | |  |  |||...||.||...| |     .|.|||||| .|.| |.
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr

subfamily_PTPN23_pd Subfamily PTPN23 97-142 3.9e-08 27.4 In-house 35-77 (288) alignment
Range on Protein: 97-142
Range on HMM: 35-77/288.0
QTNAVLSANATKNRYINILPFDETRVILSsskKEGSDYINANYIQG
.. |.   ...|||. .|||.|..|| |    ..  ||||| ....
rsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkd

subfamily_CG42327_pd Subfamily CG42327 97-144 5.4e-06 20.3 In-house 20-68 (319) alignment
Range on Protein: 97-144
Range on HMM: 20-68/319.0
QTNAVLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQGSQ
....|  .   |.|.||..|. ||||.| .   .. . |..|.|..| .
radevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyd

0045098 (Phosphotyrosine protein) phosphatases II 98-143 2.4e-10 35.7 In-house 26-62 (278) alignment
Range on Protein: 98-143
Range on HMM: 26-62/278.0
TNAVLSANATKNRYINILPFDETRVIlssskkegsDYINANYIQGS
|.|..  |. |||| .|||.| .||.         |||||.||.| 
tpalylgnldknRykdilpydhsrVk.........dYINAsyidgy

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 98-143 2.1e-09 31.5 In-house 41-84 (95) alignment
Range on Protein: 98-143
Range on HMM: 41-84/95.0
TNAVLSANATKNRYINILPFDETRVILSSskKEGSDYINANYIQGS
|     ||  |||..||.|.| |||.|..  |  |||||| ...| 
tvgsseanipknrflnifpydatrvvltt..krdsdyinacfvdgy

0049772 (Phosphotyrosine protein) phosphatases II 98-148 3.1e-09 32.5 In-house 39-88 (314) alignment
Range on Protein: 98-148
Range on HMM: 39-88/314.0
TNAVLSANATKNRYINILPFDeTRVILSSSKKEGSDYINANYIQGSQNIIR
. | | .| .||||..|||.| .||||..   .|||||||.|. | .. |.
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgflkfIa

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 99-145 7.7e-07 23.0 In-house 48-94 (290) alignment
Range on Protein: 99-145
Range on HMM: 48-94/290.0
NAVLSANA--TKNRYINILPFDETRVILSSSKKegSDYINANYIQGSQN
  .. .|.  .|||| ..   | |||||.   .   ||. |||..| . 
rkifdkntefkknrykdvvcndktrvilkdGyd..GdyvhanyvkGlka

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 99-144 2.1e-06 21.3 In-house 41-87 (440) alignment
Range on Protein: 99-144
Range on HMM: 41-87/440.0
NAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQ
 | |  |  |||| ||| .| .||.|   |    |||||| ||.| .
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

0037934 (Phosphotyrosine protein) phosphatases II 100-148 3.6e-10 35.3 In-house 5-48 (243) alignment
Range on Protein: 100-148
Range on HMM: 5-48/243.0
AVLSANATKNRYINILPFDETRVILssskkEGSDYINANYIQGSQNIIR
| | .| .|||| .|||.| .||.|     |||||||||.|..  ..|.
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvtprlia

subfamily_PTPRG_pd Subfamily PTPRG 100-144 5e-10 33.2 In-house 42-88 (563) alignment
Range on Protein: 100-144
Range on HMM: 42-88/563.0
AVLSANATKNRYINILPFDETRVILSSSK-KEGS-DYINANYIQGSQ
.    |  ||||.||...|..|| ||.   |... ||||||||.| |
sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq

0040439 (Phosphotyrosine protein) phosphatases II 100-143 9.2e-10 34.0 In-house 6-50 (249) alignment
Range on Protein: 100-143
Range on HMM: 6-50/249.0
AVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGS
| | .|  |||| .|||.| .||.||. .. ..||||||.|| |.
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 100-144 2e-06 22.0 In-house 28-69 (267) alignment
Range on Protein: 100-144
Range on HMM: 28-69/267.0
AVLSANATKNRYINILPFDETRVILSSSKKEgsdYINANYIQGSQ
 . . |. .||. . ||.|.|||||. ...|   |||| |..| .
siaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyk

0042113 (Phosphotyrosine protein) phosphatases II 101-144 4.8e-10 34.7 In-house 5-49 (245) alignment
Range on Protein: 101-144
Range on HMM: 5-49/245.0
VLSANATKNRYINILPFDETRVILSSSKKE-GSDYINANYIQGSQ
 | .| .|||| .|||.| |||.||. . . .||||||.|. |..
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyr

subfamily_CG7180_pd Subfamily CG7180 101-142 9.6e-06 19.4 In-house 38-80 (296) alignment
Range on Protein: 101-142
Range on HMM: 38-80/296.0
VLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQG
. . |  |||.....|.| .||.|.. . .| |||||| |...
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvds

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 102-143 1.3e-08 29.1 In-house 46-88 (315) alignment
Range on Protein: 102-143
Range on HMM: 46-88/315.0
LSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGS
 . |  |||||||...|..|| |    ....|||.|||.|.| 
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGy

subfamily_PTPRK_pd Subfamily PTPRK 102-144 4.9e-08 27.1 In-house 40-83 (314) alignment
Range on Protein: 102-144
Range on HMM: 40-83/314.0
LSANATKNRYINILPFDETRVILSSSKKE-GSDYINANYIQGSQ
   | .|||. .||..| .||.| . . .  ||||||..| . .
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 103-144 1.7e-09 32.3 In-house 7-49 (250) alignment
Range on Protein: 103-144
Range on HMM: 7-49/250.0
SANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQGSQ
 .|  |||| .|...|..||.| ..|  . |||||| ...| .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 104-145 1.8e-08 28.7 In-house 19-61 (270) alignment
Range on Protein: 104-145
Range on HMM: 19-61/270.0
ANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQN
 ... ||| .|||  .|||.|.. .. . . ||||||..| ..
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdg

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 104-143 1.8e-06 22.4 In-house 2-40 (237) alignment
Range on Protein: 104-143
Range on HMM: 2-40/237.0
ANATKNRYINILPFDETRVILSSSKkEGSDYINANYIQGS
 |  |||| ||  .| .||.|  .   |||||||.|..| 
enkiknrygnivaydhsrvvlkgag.sgsdyinatylkgf

Y_phosphatase Protein-tyrosine phosphatase 105-145 4.9e-10 34.6 Pfam-A 1-40 (235) alignment
Range on Protein: 105-145
Range on HMM: 1-40/235.0
NATKNRYINILPFDETRVILsSSKKEGSDYINANYIQGSQN
| .|||| .|||.|.||| | ..... ||||||||..| ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke

Y_phosphatase Protein-tyrosine phosphatase 105-145 4.9e-10 34.6 In-house 1-40 (235) alignment
Range on Protein: 105-145
Range on HMM: 1-40/235.0
NATKNRYINILPFDETRVILsSSKKEGSDYINANYIQGSQN
| .|||| .|||.|.||| | ..... ||||||||..| ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 105-141 1.9e-06 21.9 In-house 31-68 (297) alignment
Range on Protein: 105-141
Range on HMM: 31-68/297.0
NA--TKNRYINILPFDETRVILSSSKkEGSDYINANYIQ
|.   |||| .|| .|.||| |  .   ..|||||.|. 
nsslrknryrdilatddtrvkllrvi.terdyinadyvv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 106-275 5.9e-16 53.1 In-house 48-177 (350) alignment
Range on Protein: 106-275
Range on HMM: 48-177/350.0
ATKNRYINILPFDETRVILSSSK---------KEGSDYINANYIQGSQNIIRPDPSVmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv
 .|||| ||||.. .||.|  |           ...|||||||.. ..  .. .|.                                            
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf...........................................

gclgrtaEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEplewyEEDITVTLTDR-DEFKNIKASNL
        || || ||  |  ||.|..|. .|.|.. | |  |      ..||.. .      .|||| |... ..  .|. | |
.......kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs.....ydditvklaskwenimgindssl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 106-241 2.6e-12 40.8 In-house 49-150 (349) alignment
Range on Protein: 106-241
Range on HMM: 49-150/349.0
ATKNRYINILPFDETRVILSSSKKEgSDYINANYIQGSqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskGSMGNTYINASFVG--CLGRTA
 .|||| .|||.. .||.|  | |  |  |.|   .                                          ... . |||| ..    .    
faknrykdilPyehsrvklkkslks.skvikastsesd........................................sgklddyinanylkltrisvek

EYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----D
 || || ||  |  ||.|..|   |.... | . .|.     |
kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

0045098 (Phosphotyrosine protein) phosphatases II 145-307 1.4e-27 92.3 In-house 16-178 (278) alignment
Range on Protein: 145-307
Range on HMM: 16-178/278.0
NIIRPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPlskgsmgnTYINASFVGCLgrTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE----
... ..|| . .|  ..| .|||    ||.|..||          |||||.. .   . ..|.||.|| .|  |||.|. | ...|.| | ...|     
llllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

-DEYWPDSEPLEWyeEDITVTLTDRDEFKNIKASNLEIESD----MNESHQALTMFQISNWPSDGTTPND---HF
 ..|||....|..  .|.||||.. ......    |...       .     .|.... .||  |. ...   .|
caqywpeggslty..gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 145-309 8.5e-22 72.6 In-house 31-200 (319) alignment
Range on Protein: 145-309
Range on HMM: 31-200/319.0
NIIRPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-
..  ...  .. | ...|. |||    |..|  || ||  .|. | .||||||.    .  ..| || ||..|  |||.|. |... ..|.|  . |.  
llkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

----EYWPDSEPLEwYeEDITVTLTDRDEFKNIKASNLEIESDMNES-HQALTMFQISNWPSDGtTPNDHFIM
    .|||. .. | |   ..||| ...| ...  ..|...   .|     .. ||  .|| ..  |..   .
vklkkywpeenfee.y.GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhd.vPekatsl

0043336 (Phosphotyrosine protein) phosphatases II 148-308 4.8e-30 100.4 In-house 31-194 (278) alignment
Range on Protein: 148-308
Range on HMM: 31-194/278.0
RPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----
. ..  .. |  |.|  |||    ||.|..|| ||  .  ....|||||.| .  .. ..|.||.|| .|  |||.|. | .|...|.| . .| .    
sfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkc

-EYWPdsEPLEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFI
 .|||  .  . | .|.||||.. .......  .||..   .   .  | ..  .|| |...| .  .
aqYwp..ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 148-302 1.5e-19 65.0 In-house 30-189 (315) alignment
Range on Protein: 148-302
Range on HMM: 30-189/315.0
RPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE---
 ||..  . | ...|  ||| .  ||.| .|| |     |  . |||||..  .     || .| ||  .  |||.|.|. .|  .|..   .|.|    
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

--YWPDSEPLEWYEEDITVTLTDRDEFKNIKASNLeIESDMNESHQaLTMFQISNWPSDGTT
  |||| .        | |.| . .   .  | .| .  . .||.. .| ||  .||  |. 
rqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrt.vtqfqftewPdkGvd

0040438 (Phosphotyrosine protein) phosphatases II 149-307 3.9e-33 110.5 In-house 30-192 (317) alignment
Range on Protein: 149-307
Range on HMM: 30-192/317.0
PDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGSM--GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----
 ... .. |  |.|  |||    ||.|..|| ||  .   ...|||||.| .  .. ..|.||.|| .|  |||.|. | .|.|.| | . || .     
lkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekca

EYWPDsEPLEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHF
.|||. .    | .|.||||.. .| ..|.  .||.| . .. .  .| |.  .|| |...| .. 
qYwpl.getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspd

subfamily_PTPRN_pd Subfamily PTPRN 149-248 3.3e-15 50.6 In-house 43-150 (297) alignment
Range on Protein: 149-248
Range on HMM: 43-150/297.0
PDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVG-CLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEE-----E
 .||. . | ...|  |||. | ||.| .|| |.. .    . |||||..     |.. || || |||.|  |||.|. |. | |.| | ..||     .
aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

DEYWPDSE
..||||  
krywpdeG

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 149-301 1.3e-14 48.4 In-house 32-147 (392) alignment
Range on Protein: 149-301
Range on HMM: 32-147/392.0
PDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDeywpd
|| .  . | .. |  ||| .  ||.| .|| |     .  . |.|||.. ..     || .| | | .  |||.|... .|  ....  ..| |     
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

seplewyeeditvtltdrdefknikasnleiesdMNESHQALTMFQISNWPSDGT
                                    ..... . |....|| .. 
..................................kgddartvaqfhftewPdkdv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 149-253 2.8e-08 27.7 In-house 40-149 (310) alignment
Range on Protein: 149-253
Range on HMM: 40-149/310.0
PDPSVMKDAFNpNNSWKNREGAGLPFDFNRVPLSK-GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----E
 |.|.  .|.. ..  |||    .  |  || |    |  . || | .|      . .| .| ||  | .|||.|...   . ...|  | ||       
qdssltyeayk.kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvg

YWPDSEPLEWY
|||     | |
ywpslgvtety

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 149-277 5e-07 23.7 In-house 23-160 (281) alignment
Range on Protein: 149-277
Range on HMM: 23-160/281.0
PDPSVMKDAFN-PNNSWKNREGAGLPFDFNRVPLSK---GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE----
  || .  .|| | |  |||      .|  || |           || | ..        ||||| |  .|  |||.|. .     .|.|  . |     
dppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

-DEYWPDSEPLEWYEEDITVTLTDRDEFKNIKASNLEI
  ||.|         . ..|.  |    | . .. |..
caeyfprnahcclqfdklsvsyedstvnkslvttrlnl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 150-301 2.5e-14 48.2 In-house 36-193 (325) alignment
Range on Protein: 150-301
Range on HMM: 36-193/325.0
DPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS-KGSMG-NTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE----Y
|.  .| |  |.|  |||    ...| .|| |  |.  .   |||||..    .   .. .| ||..|  |.|...|. .  |.|||  ......    |
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavy

WPDSEPLEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
||.          . | |   .|. .     |..    .   ...  ||.  |.  |.
wpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 151-309 1.3e-24 81.8 In-house 35-197 (318) alignment
Range on Protein: 151-309
Range on HMM: 35-197/318.0
PSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEY
 .   .. .| |  |||    |..|  || |.  .|..|  ||||...    |. .|| .| ||..|  |||.|. |..  |.|.|  .||.     . |
tvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry

WPDSEPLEWyeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTtPNDHFIM
||.... ..  ....|.|... |...    ..... . .|...    ... .||  |. |..   .
WPskgsrsy..gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv.pesgasl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 151-304 4.1e-18 60.2 In-house 27-186 (287) alignment
Range on Protein: 151-304
Range on HMM: 27-186/287.0
PSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS-KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVL-GSVEEED----EYW
. ..| | .  .  ||| .  ||.| .|| || .| .|  |||| .|    .  ..| .| |.| |  |||...||... .....   |||      .||
tatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

PDSE-PLEWYeeDITVTLTDRDEFKN-IKASNLE-IESDMNESHqALTMFQISNWPSDGTTPN
|. | |.       .|.| |.|  .       |  |. . .|..  .  ... .||... .| 
PerevPmrvG..GysvvlldydikePeygvralrlidletrear.vvkqldllswPdkvlaPt

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 151-303 2.5e-10 34.9 In-house 30-193 (307) alignment
Range on Protein: 151-303
Range on HMM: 30-193/307.0
PS-VMKDAFNPNnSWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYW
|  |  .||. | . |||       | .|. .    .   || | ..|   .   .| .| || .|  .|| |... .|. ...|  | |      ..||
pegvtveafsan.tdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PDSEP--LEWYEEDITVTLTDRDEF------KNIKASNLEIesDMNESHQALTMFQISNWPSDGTTP
|  |   | . |.  |.....          . |. ..|..  |  .  .... .| .|||  |. .
pleegqklvfgeapntisvanlgakklapdedlinvttlkv..dwaqksrtiqhlqwenwpdrgvpq

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 151-243 3.2e-10 34.1 In-house 37-123 (303) alignment
Range on Protein: 151-243
Range on HMM: 37-123/303.0
PSVMKDAFNpNNSWKNREGAGLPFDFNRVPLSKGSmgntYINASFVGcLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEY
||| |. |  .|  |||    . .|  .| ||  |    || ||..  |  .   |||| ||. |. |||.|..|..|.....| .  | |..
psvsknqfv.knmdknrfvdvicldhskvklsdss....yihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydkl

subfamily_PTPRD_pd Subfamily PTPRD 153-301 5.8e-30 99.4 In-house 39-192 (564) alignment
Range on Protein: 153-301
Range on HMM: 39-192/564.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWP
 .. | .| |  |||    ...| .|| ||  .|  |  ||||||.    .  .|| ||.|||.| .|||.|. |..... | | ..||...     |||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

DSEpLEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
...  | | ...||||..  |....   .....   ... .  . |.  .||. | 
ekg.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv

subfamily_PTPN3_pd Subfamily PTPN3 153-312 9.2e-20 65.7 In-house 32-196 (280) alignment
Range on Protein: 153-312
Range on HMM: 32-196/280.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGSMgnTYINASFVGC----LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EY
 .. |  |.|  |||    ||.|  || |....    ||||..|       |    || || |||.|. |||.|. |......|.| .. |.      .|
aisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPDSEPLEWYEeDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFIMVEV
||..|    |  ...|... .|| |..   .| ..   .. .. .. .|  .|| | . |.|.  ..|.
WPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp.dhgvPddsadflef

subfamily_PTPN14_pd Subfamily PTPN14 153-305 1.1e-15 52.4 In-house 40-201 (300) alignment
Range on Protein: 153-305
Range on HMM: 40-201/300.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGSM-GNTYINASFVGC--LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYW
... | .|.|  |||    ||.. ||| ||      . ||||| .     |.. .|| .| ||  |  |||.|. | .|...| | . ||.      .|.
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PDSEP--LEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGtTPND
|..|    .   .   ||   ... . . .. |...  . . .. . ..|  .|| .|  |.|
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhg.vPeD

subfamily_egg_pd Subfamily egg 153-248 2.1e-10 34.8 In-house 31-131 (307) alignment
Range on Protein: 153-248
Range on HMM: 31-131/307.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED---EYWPDS
 .. |.. ||  | |.      |. || |   .|   . .| |  |       |.||.| || .|  |||.|. . .|. .|.| |  | .    ||| .
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpka

E
|
e

DSPc_SM00195 154-305 1.4e-31 105.2 In-house 18-179 (263) alignment
Range on Protein: 154-305
Range on HMM: 18-179/263.0
MKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
...|  ..|. |||    ||.| .|| |.|     |..||||... .  .. .||.||.|| .|  |||.|..|..|.. |.| . ||.     |.|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

SEPLEWYEEDITVTLTDRDEFK-NIKASNLEIESDMNESHQALTMFQISNWPSDGTT--PND
..  ..  ..|.|.|.. .. | .|.  .||.. . .| .. .| .|. |||  |.   ...
esggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks

PTPc_SM00194 154-305 1.4e-31 105.2 In-house 18-179 (263) alignment
Range on Protein: 154-305
Range on HMM: 18-179/263.0
MKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
...|  ..|. |||    ||.| .|| |.|     |..||||... .  .. .||.||.|| .|  |||.|..|..|.. |.| . ||.     |.|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

SEPLEWYEEDITVTLTDRDEFK-NIKASNLEIESDMNESHQALTMFQISNWPSDGTT--PND
..  ..  ..|.|.|.. .. | .|.  .||.. . .| .. .| .|. |||  |.   ...
esggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks

0039614 (Phosphotyrosine protein) phosphatases II 154-308 1.4e-30 102.2 In-house 48-204 (297) alignment
Range on Protein: 154-308
Range on HMM: 48-204/297.0
MKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS---MGNTYINASFVGCLGR-TAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE----DEYWP
.. |  |.|  |||    ||.|..|| |.      ....|||||.| .  . | ..|.||.|| .|  |||.|. | .|.|.| | . .|     ..|||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywp

DSEPlewYEEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPsDGTTPNDHFI
...    . .|.||||.. .. ....  .||..   |.    .|.||  .|| |...|... .
eegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslel

subfamily_PTPRB_pd Subfamily PTPRB 154-310 5.5e-24 79.7 In-house 43-202 (293) alignment
Range on Protein: 154-310
Range on HMM: 43-202/293.0
MKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
.| | .. |. |||    ||.| .|| |   |.. |. ||||...  .  . |.| || || .|  |||.|..|......|.|  . |.     .||||.
vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

SEPLEWYeEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPSDGtTPNDHFIMV
 |    |  ||.|||.  .| ..    .|.||   ..... .. ..   ||  |  |..   ..
deepvly.Gdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhg.vPektktll

0051299 (Phosphotyrosine protein) phosphatases II 155-306 1.3e-32 108.8 In-house 42-201 (288) alignment
Range on Protein: 155-306
Range on HMM: 42-201/288.0
KDAFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDs
. |  |.|  |||    ||.| .|| ||   |. |..|||||.. .  .. ..|.||.|| .|  |||.|. | .|.| |.| ...|      . |||. 
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.

EPLEWYeEDITVTLTDRDEFKNIKASNLEIESD----MNESHQALTMFQISNWPsDGTTPNDH
.  . | .||||||.. .......  .||..       .. ..  | |.  ||| |  .|.. 
ggslty.gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdsp

0047943 (Phosphotyrosine protein) phosphatases II 155-305 1.3e-32 108.7 In-house 31-185 (273) alignment
Range on Protein: 155-305
Range on HMM: 31-185/273.0
KDAFNPNNSWKNREGAGLPFDFNRVPLskGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEP
. |  |.|  |||    ||.| .|| |  |. |. |||||.| .  .. ..|.||.|| .|  |||.|. | .|.|.|.| ...|      . |||... 
svallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegg

L-EWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPND
  ... ...||||.. .......  .||...  ..     | |.  .|| .|. |. 
elsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppsl

subfamily_PTPRG_pd Subfamily PTPRG 155-308 2.9e-26 86.8 In-house 40-205 (563) alignment
Range on Protein: 155-308
Range on HMM: 40-205/563.0
KDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGN-TYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGS-----VEEEDEYWPD
. . .|.|  |||.   ...|  || ||. .   ..  ||||...    .. ..| ||.||.||  |||.|. |..|...|..        ...| ||| 
ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk

SEPLEWyeEDITVTLTDRDEFKNIKASNLEIES-DMN-----ESHQALTMFQISNWPSDGTTPNDHFI
 |....  . ..|||.... .      .| |.   ..     ....  . .. ..||  |.     . 
desety..galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpv

subfamily_PTPN1_pd Subfamily PTPN1 155-300 3.1e-18 60.5 In-house 25-176 (290) alignment
Range on Protein: 155-300
Range on HMM: 25-176/290.0
KDAFNPNNSWKNREGAGLPFDFNRVPLSKGSMgnTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSE-
..| .|.|  .||     |.|  |. | ...    |||||.|       .||||| ||..|   ||.|. |..   .|.|  | |..     .|||  | 
reaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

--PLEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDG
   |.  .  ..|.|  ... .. . . ||.|    .  . .. |    ||  |
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfg

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 155-240 2.2e-07 24.8 In-house 43-133 (305) alignment
Range on Protein: 155-240
Range on HMM: 43-133/305.0
KDAFNPNNS-----WKNREGAGLPFDFNRVPLSKGSmGNTYINASFVGCLG-RTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE
. ||| |.|      |||       | . | |.| |    || | .|||       .| .| || .|  .|| |.....|. .|.|    | 
qvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvel

0046845 (Phosphotyrosine protein) phosphatases II 156-308 9.9e-32 105.9 In-house 22-186 (284) alignment
Range on Protein: 156-308
Range on HMM: 22-186/284.0
DAFNPNNSWKNREGAGLPFDFNRVPLSKGSMG---NTYINASFVGCL-----GRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DE
 |  |.|  |||    ||.| .|| |.  . .   ..|||||.| .       .. ..|.||.|| .|  |||.|..| .|.|.|.| . .|      . 
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YWPDSEPLEWYeEDITVTLTDRDEFKNIKASNLEIESDM-NESHQALTMFQISNWPsDGTTPNDHFI
|||...   .| .|.||||..........  .||..    .. .  .| |.. .|| |  .| .  .
Ywplegevlty.gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppsped

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 156-310 1.2e-24 81.9 In-house 41-197 (287) alignment
Range on Protein: 156-310
Range on HMM: 41-197/287.0
DAFNPNNSWKNREGAGLPFDFNRVPLSkgSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPL
 .  ..|  |||    |. | .||.|      . ||||.|.       ..|... |...|  .|||.. .|.|...|.|   .|.||     |||... .
hniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksv

EWyeEDITVTLTDRDEFKNIKASNLEIESDM-NESHQALTMFQISNWPSDGTTPNDHFIMV
     . ...|....  ..    .||.. .. ....| .. .|| ||.| |  ..   |..
vl..GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

0037934 (Phosphotyrosine protein) phosphatases II 156-308 5.5e-24 80.5 In-house 4-154 (243) alignment
Range on Protein: 156-308
Range on HMM: 4-154/243.0
DAFNPNNSWKNREGAGLPFDFNRVPLsKGsmgNTYINASFVGCLGRtaeYILTQHPLADTSMD----FWKMMLERHVNVLVVLGSVEEE-----DEYWPd
 |  |.| .|||    ||.|..|| | .|   . ||||... ...|   .|.||.|| .|  |    ||.|. | ...|.| | . .|      ..||| 
iallpenlsknrysdilpydhsrvkl.eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

S-EplewYEEDITVTLTDRDEFKNIKASNLEIESDM-NESHQALTMFQISNWPsDGTTPNDHFI
. .    . .|.||||..  ......  .|..|    .. ..  . ..  .|| |...|... .
gev....tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp.dhgvPdsped

subfamily_PTPN6_pd Subfamily PTPN6 156-308 1.4e-21 71.8 In-house 48-207 (306) alignment
Range on Protein: 156-308
Range on HMM: 48-207/306.0
DAFNPNNSWKNREGAGLPFDFNRVPL-SKGSMGNTYINASFVG--CLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDS
..  |.|  |||  . |||| .|| | ... .|..||||...     | ...|| ||  | .|  |||.|... . .|.|..    |        ||||.
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

EPLEWyEEDITVTLTDRDEFKNIKASNLEIE-SDMNESHQALTMFQISNWPSDGTtPNDHFI
|  |    .|.|| .. .. .. .  .| ..  . ..... .  ..  .||  |. |.|   
eekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgv.pkdpga

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 156-306 1.7e-18 61.8 In-house 35-189 (281) alignment
Range on Protein: 156-306
Range on HMM: 35-189/281.0
DAFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSE
 .....|  |||      .|  || ...   .. . ||||.||  .   .||| || |. .. ..||.|..|..|...|..    |.       |||| .
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

PlEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHqALTMFQISNWPSDGTtPNDH
  |    |.||. | . | ..    ....| . .|.   .. ..  .||  |  |.. 
s.elkygdvtvkstaeeekatyierkfkleresgetr.eveqlaytaWPdhGv.Patt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 156-304 3.4e-15 50.5 In-house 49-200 (290) alignment
Range on Protein: 156-304
Range on HMM: 49-200/290.0
DAFNPNN-SWKNREGAGLPFDFNRVPLSKGSMGNtYINASFVGclGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEP
. |. |    |||       |  || |. |  |. |. | .|   |  | .|||| .|.|| .|.|.|.|. .| ..|.|  . |.     ..|.|. | 
kifdkntefkknrykdvvcndktrvilkdGydGd.yvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

LEWYEEDITVTLTDRDE-FKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPN
      .|||. .  |.  .||.   | .    .  .  |  ..|  || | . ..
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp.dksval

0036941 (Phosphotyrosine protein) phosphatases II 157-303 2.1e-33 111.3 In-house 34-185 (297) alignment
Range on Protein: 157-303
Range on HMM: 34-185/297.0
AFNPNNSWKNREGAGLPFDFNRVPLskGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLE
| .|.|  |||    ||.|..|| |  .. |. |||||.| . ... ..|.||.|| .|  |||.|..| .|.|.|.| ...|      ..|||. |. .
allpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeges

WYEEDITVTLTDRDE--FKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTP
.. .|.||||.. ..  .....  .||..   |. .  .|.|.. .|| .|. .
ltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe

0050432 (Phosphotyrosine protein) phosphatases II 157-309 5.9e-33 109.9 In-house 63-219 (308) alignment
Range on Protein: 157-309
Range on HMM: 63-219/308.0
AFNPNNSWKNREGAGLPFDFNRVPLskgSMGNTYINASFVGCL--GRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEP
|  |.|  |||    ||.| .|| |   . |..|||||.| .   ... ..|.||.|| .|  |||.|. | .|.| |.| . .|      ..|||... 
allpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelg

-LEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFIM
   .. ...||||.. .......  .||..   ..    .| |.  ||| |. .|..  |.
ggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeil

0045450 (Phosphotyrosine protein) phosphatases II 157-304 9.8e-30 99.7 In-house 50-213 (307) alignment
Range on Protein: 157-304
Range on HMM: 50-213/307.0
AFNPNNSWKNREGAGLPFDFNRVPLSKGS---MGNTYINASFV--------GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----
|  |.|  |||    ||.| .|| ||  .    .. |||||.|        ..  .. ..|.||.|| .|  |||.|. | .|.|.| | . .| .    
allpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekc

-EYWPDSePLEWYEEDITVTLTDRDEFKNIKASNLEIESD-MNESHQALTMFQISNWPSDGTTPN
 .||||.   |.. ...||||.. .. ....  .||..    .. .  .| |.  .|| .|. |.
aqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 157-308 2.1e-29 97.7 In-house 51-207 (298) alignment
Range on Protein: 157-308
Range on HMM: 51-207/298.0
AFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEP
| .|.|  |||    ...|. || |.|  .    .||||||.    ..  .|.||.||  |  |||.|. |......|.| ..|| |.     ||||.. 
arkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk

lEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPNDHFI
 | | ..|||.|  ..|| ..   .|....  .|... . ... ..||. |.. | . .
.ety.geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsv

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 157-310 4.5e-26 86.4 In-house 41-202 (290) alignment
Range on Protein: 157-310
Range on HMM: 41-202/290.0
AFNPNNSWKNREGAGLPFDFNRVPLSKGSM----GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDS
.. ..|. .||    .. | ||..| . |      | ||||...       .||.|| |. .| .||||.. ...| ..|.| .. ||..     |||||
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds

EPLEwYEEdITVTLTDRDEFKNIKASNLEIESDMN-ESHQALTMFQISNWPSDGTTPNDHFIMV
.  . |.| ....|..  .....   .||.... . ...| .| .||.||.|.|  .| . |..
dtka.yge.fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 157-312 1.1e-24 82.1 In-house 42-200 (288) alignment
Range on Protein: 157-312
Range on HMM: 42-200/288.0
AFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSV-EEE----DEYWPDSEP
. ...|  |||    ||.|..|| | |     |. |||||..   ... .|| || |||||  |||... |.... .| | .. |..    .|||||.. 
grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk

LEWYEeDITVTLTDRDEFKNIKASNLEIESDMNEshQALTMFQISNWPSDGtTPNDHFIMVEV
 . |  ..||||..  | ...   .|..| ...|    .| .|   || .|  |...  ..|.
pknyG.svtvtlveskeledfvlrklllekkkte..leitqyqylaWpdhg.vPeskapllel

subfamily_PTPN12_pd Subfamily PTPN12 157-303 5e-22 73.1 In-house 35-187 (290) alignment
Range on Protein: 157-303
Range on HMM: 35-187/290.0
AFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEP
. ...|  |||    ||.|..|| ||| .   |. ||||.|.     . ||| .| ||..|  |||.|. | .|...|..  . | .      |||..  
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

LEWYEEDITVTLTDRDEFK-NIKASNLEIESDmnESHQALTMFQISNWPSDGTTP
 |   ....|||.. . .. ..    |..| .  . .. .. |.  .||  |.  
eelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPs

subfamily_PTPRA_pd Subfamily PTPRA 157-312 1.7e-19 64.9 In-house 53-216 (330) alignment
Range on Protein: 157-312
Range on HMM: 53-216/330.0
AFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEP
| . .|  |||    ||.||.|| ||  .|     ||||||.    .  ..| .| |...|  |||.|. |..   .|.|  ..| .|     ||||   
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl

leWYEEDITVTLTDRDEFKNIKASNLEIE--SDMN--ESHQALTMFQISNWPSDGTtPNDHFIMVEV
  .   .|.|.. |  . ...   .. ..  .|.   .... .. |    ||  |  | .   |...
..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv.PfepiGmlkl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 157-301 1e-16 55.8 In-house 44-190 (315) alignment
Range on Protein: 157-301
Range on HMM: 44-190/315.0
AFNPNNSWKNREGAGLPFDFNRVP--LSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----E-YWPDSep
| . .|  |||    ...|  ||   | .   .  |.||.|.    .   || .| |.. .  |||... | ..  .|.| .. |..    | ||||   
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

lEWYEEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPSDGT
 .     ||||. . . ....    | . .  ..  . .  .... ||  | 
.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgv

subfamily_ptpA1_pd Subfamily ptpA1 157-246 4.8e-09 30.4 In-house 42-137 (418) alignment
Range on Protein: 157-246
Range on HMM: 42-137/418.0
AFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLgRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
  .  |. |||    || .. || | |     |. |||| ..       ..| || || .|  |||.|. | .. ..|.|    |.     | |||.
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

0042113 (Phosphotyrosine protein) phosphatases II 158-308 4.2e-27 90.6 In-house 5-159 (245) alignment
Range on Protein: 158-308
Range on HMM: 5-159/245.0
FNPNNSWKNREGAGLPFDFNRVPLSKGSMG--NTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDsePL
  |.|  |||    ||.|..|| ||  .    ..|||||.|..  .|  .|.||.||..|  |||.|. | .....| | . ||      ..|||.    
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

EWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFI
... .|.||||.. . .....  .||.. . .  ..  . ..  .|| |...|... .
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllel

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 158-301 5.6e-23 76.4 In-house 5-152 (250) alignment
Range on Protein: 158-301
Range on HMM: 5-152/250.0
FNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----EYWPDSEPlE
 .|.|  |||    ...|  || | | .      ||||||.     .  .| ||.|| .|  |||.|.||......|.| ...|..    .|||  .. |
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka.e

WYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
 |  |.||.| ...|| ...  .| . .  ..... .  ..  .||  | 
ky.GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv

subfamily_PTPN9_pd Subfamily PTPN9 158-311 2.4e-20 67.8 In-house 38-197 (297) alignment
Range on Protein: 158-311
Range on HMM: 38-197/297.0
FNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPL
  . |. |||    | .|  || |.|  .     ||||.||    .   .| || ||  |. |||.|. |..| |.|.   |.|.      .|||..|  
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

EWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTtPNDHFIMVE
     |..|.  . .| .. | . |||.   .| .. .| ||.  ||  |. |..   ...
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGv.Pssaaslld

0040439 (Phosphotyrosine protein) phosphatases II 159-305 9e-28 93.0 In-house 8-159 (249) alignment
Range on Protein: 159-305
Range on HMM: 8-159/249.0
NPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLE
 |.|  |||    ||.|..|| ||  .|  .. |||||.. .  .. ..|.||.|| .|  |||.|. | ...|.| | | .|      ..|||....||
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

WyeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPND
.  .|.||||.. .......  .||..   . ..   . .|. .|| .|. |. 
y..gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsf

subfamily_Ptp69D_pd Subfamily Ptp69D 159-305 4.5e-23 76.8 In-house 45-200 (307) alignment
Range on Protein: 159-305
Range on HMM: 45-200/307.0
NPNNSWKNREGAGLPFDFNRVPLSKGSM--GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLE
. .|  |||  .  .|| .|| |.|  .    .||||||.     . ..|  | |.  |  |||.|. | .|...|.|  ..| ..     |||. .  .
kkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevq

wYEeDITVTLTDRDEFKNIKASNLEIESDMN-----ESHQALTMFQISNWPsDGTTPND
 |. || |.| . .. ..    .|..    .     | .. .. ..  .|. | . |. 
.yg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPev

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 159-306 2.1e-20 68.4 In-house 22-169 (284) alignment
Range on Protein: 159-306
Range on HMM: 22-169/284.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGsVEEEDEYWPDSEPLEWYEED
 ..|  ||| |  |.|| |.| | .  |  .  ||||||.    |   || || || .|  |||.|. | ..  .|.|   .   .|||     .  . .
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kdkcsqywplkivikeerfk

ITVTLTDRDEFknIKASNLEIESDMNE-SHQALTMFQISNWPSDGTTPNDH
. |.. .  |       ..|.  | .|   . .. | .  ||  |      
vkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdyps

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 159-305 3.2e-20 67.7 In-house 58-204 (319) alignment
Range on Protein: 159-305
Range on HMM: 58-204/319.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGsVEEEDEYWPDSEPLEWYEED
 ..|  ||| .  |.|| |.| | .  |  .  |||||||    |   || .| || .|  |||.|. | ..  .|.|   .   .|||     .  . .
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kdkcsqywplkivikeerfk

ITVTLTDRDEFknIKASNLEIESDMNE-SHQALTMFQISNWPSDGTTPND
. |.. .  .       ..|.  | .|   . .| | .  ||  |     
vkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdyp

subfamily_CG7180_pd Subfamily CG7180 159-304 1.6e-18 61.4 In-house 39-198 (296) alignment
Range on Protein: 159-304
Range on HMM: 39-198/296.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE----YWPDSEpLEW
. .|  |||.   .|.|.||| |.|  |   . ||||..|  . . .||| |. |  .|  .||... ..... .|||  . .  .    |||     | 
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keq

YEeDITVTLTDRDEFKNIKASNLEIESD------MNE----SHQALTMFQISNWPSDGTTPN
|  .| | ..  ... |.|  .. .         ...        ...||.  |...   | 
yg.eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPl

subfamily_PTPRK_pd Subfamily PTPRK 159-304 2.3e-18 61.1 In-house 40-190 (314) alignment
Range on Protein: 159-304
Range on HMM: 40-190/314.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLe
. .|  ||| |  |..|  || |    |   . ||||...    |.|..| ||.|| .|  |||..... .   .|.|  . |.      .|||.     
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

wYeEDITVTLTDRDEFKNIKASNLEIES--DMNESHQALTMFQISNWPSDgTTPN
 | .|| |.| . .  ... .  . .|      | .. .  ||  .||.   .|.
.y.gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPv

subfamily_PTPN13_pd Subfamily PTPN13 159-311 2.9e-18 61.1 In-house 34-190 (273) alignment
Range on Protein: 159-311
Range on HMM: 34-190/273.0
NPNNSWKNREGAGLPFDFNRVPLSKGSMgntYINASFVGCLG--RTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLE
. .|  |||    ||.|  ||.|.. .    |||||..       . |||..| || .|  |||.|. |....|.... .  |..      |||.|.  .
kkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

WYEED-ITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFIMVE
   .. ..|.| .  . .. . ..|...    .  . .. ..  .|| |  .|.    ...
lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwP.dhgvPssaaellq

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 159-297 1.6e-16 55.1 In-house 30-167 (267) alignment
Range on Protein: 159-297
Range on HMM: 30-167/267.0
NPNNSWKNREGAGLPFDFNRVPLSKGSmgNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE--DEYWPDSEPLEWYEED
  .|  .||   .||.| .||.|..    . |||||.| .  .   .|.|| ||  |  ||.... ...| | |.|  | ..    .||         .|
aeknqernrlddnlpyddtrvilrtke..eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqd

ITVTLTDRDEFKNIKASNLEIESDmNESHQALTMFQISNWP
.||  .   | .. .   ||..   ||| . .|..   .| 
ltvehslekeendyqiitlelkfk.nesahnvtlyyykkwn

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 159-308 1.1e-09 32.5 In-house 45-208 (305) alignment
Range on Protein: 159-308
Range on HMM: 45-208/305.0
NPNNSWKNREGAGLPFDFNRVPLsKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWP--DSEPLE
. ... |||      .| ||| | .|.    || | .|     .  .| || || .|  ||| | |. .|. . .|  . |       ||..  | . ||
eaqeagknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

WYEED--ITVTLTDRDE--F-----KNIKASNLEIESDMnESHQALTMFQISNWPSDGTTPNDHFI
. |..  |.| .    .  |      ..... | ||    |. .  | .   .||  |  . |  |
feekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaadlai

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 160-302 4.2e-17 56.9 In-house 31-178 (283) alignment
Range on Protein: 160-302
Range on HMM: 31-178/283.0
PNNSWKNREGAGLPFDFNRVPLSKGSMgnTYINASFVG---CLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLE
 .|  |||.   .| | .|| |   |   .||||.|.       .  .|| .| || .| .|||||. ....  .|.|  . |. .     |||     .
denkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed

WYEedITVTLTDRDEFKNIKASNLEIESD-MNESHQALTMFQISNWPSDGTT
. |   |||| .    .     .| .  .   .|   |. .|. .| . |  
yGe..ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeq

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 160-311 8.6e-17 56.1 In-house 26-185 (274) alignment
Range on Protein: 160-311
Range on HMM: 26-185/274.0
PNNSWKNREGAGLPFDFNRVPLSKG-SMGN--TYINASFV-GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPL
. .. |||  . || .  || |..  |  .  .|||| .. |  ...  |. || ||. | .|||.|. ...|.|.|.|  ..|..|     |.||.| .
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

EWYE--EDITVTLTDRDEFKNIKASNLEIESDMNesHQALTMFQISNWPsDGTTPNDHFIMVE
|  |  .|. .. ..  | .. .  .| ...  .  .. .. .  ..|| |  .|.|   ...
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWP.dhksPddantlld

0049772 (Phosphotyrosine protein) phosphatases II 160-304 2.1e-10 36.3 In-house 44-195 (314) alignment
Range on Protein: 160-304
Range on HMM: 44-195/314.0
PNNSWKNREGAGLPFDfNRVPLSKGSM-GNTYINASFVGCLgrtAEYILTQHPLADTSMDF----------WKMMLERHVNVLVVLG-------------
. |  |||    ||.| ||| |.. .. |  |||||.| .      .| ||.||  |  ||          |.|.|.   || .. .             
flnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------SVEEEDEYwpdSEPLEWYEEDITvtltdrdefknikasnlEIESDMNESHQA-LTMFQIsNWPSdGTTPN
          .    .   .|| ... |..                  |.  | .   .. .. ..| ..|  |..| 
daAlgKtpllildgng...neptaadlellk.................eelydpelferlgikylri.pvpD.gsapl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 161-302 2.1e-23 78.0 In-house 45-194 (305) alignment
Range on Protein: 161-302
Range on HMM: 45-194/305.0
NNSWKNREGAGLPFDFNRVPLSKGSMGN--TYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLEWY
.|  |||  .  ..|..|. |.. .  .   |||||.|    |  .||..| || .|  |||....| .|...| |  . |...     |||.|.  .  
ankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke

EEDITVTLTDRDEFKNIKASNLEIES-DMNESHQALTMFQISNWPSDGTT
 ....|.|... ....    .|.|   | ..  .... .|. .|| .|  
fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvp

subfamily_PTPN23_pd Subfamily PTPN23 161-301 5.9e-22 72.8 In-house 42-186 (288) alignment
Range on Protein: 161-301
Range on HMM: 42-186/288.0
NNSWKNREGAGLPFDFNRVPLSkgSMGNTYINASFVGCLGRT-AEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYE
 .| |||    ||.| ||| |   .  . |||||||  |  .  ..| || ||. |. |||.|. |....|.|.| | ||      |.||| ..      
lyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

EDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
.|..||| .  | ..    .|..|   ..  . ..  |. .||. | 
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 161-305 7.7e-15 49.0 In-house 42-191 (515) alignment
Range on Protein: 161-305
Range on HMM: 42-191/515.0
NNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPD--SEPLE
 |  ||| .  ||.| .|| |   . .  . |.|||..  .     || .| |.  .  |||...|. .|  ....   .|.|      ||||  .. ..
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

WyeEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPSDGTTPND
.    | | |   .   .    .|..    ..  ...| |.  .||  |. .. 
f..Gsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkht

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 161-301 1.7e-14 48.6 In-house 2-148 (237) alignment
Range on Protein: 161-301
Range on HMM: 2-148/237.0
NNSWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCL-GRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLEWYE
.|  ||| |    .| .|| |     |  ||||...  . |   .|| .| ||  .  |||.|. . .  |.|.|  . | .     .|||...  . | 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

eDITVTLTDRDEFKNIKASNLEIESDMNESH-QALTMFQISNWPSDGT
  .||.|. ..|| .     | .   ..  . . .  .|.. ||  | 
.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 161-241 7e-08 26.3 In-house 33-114 (332) alignment
Range on Protein: 161-241
Range on HMM: 33-114/332.0
NNSWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLAD-TSMDFWKMMLERHVNVLVVLGSVEEED
||   ||      ||..|| |.     . . |||.|    . . ||..| |. | |   ||.|. ||. ....|.| ..|..
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 162-303 2.7e-17 57.8 In-house 51-194 (297) alignment
Range on Protein: 162-303
Range on HMM: 51-194/297.0
NSWKNREGAGLPFDFNRVPLSKGSM--GNTYINASFVGCLGRtaEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE----YWPDSEPLEwyEE
|  |.|    ||.|..|| |          |.|||||       ..| || |  .|  |||.|.|. .|...|.|   .|.|.    ||.|.   .    
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt..fG

DITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTP
|..|.|.  .| .     .||.. . . ... .  .|  .||..    
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver

0041856 (Phosphotyrosine protein) phosphatases II 162-304 2e-13 45.8 In-house 1-95 (182) alignment
Range on Protein: 162-304
Range on HMM: 1-95/182.0
NSWKNREGAGLPFDFNRvplskgsmGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGsveeEDEYWPDSEplewyeeditvtl
|  |||    ||.|..|        ...||||... .  .. ..|.||.|| .|  ||..|. |......| |     |. |||. .             
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpell.............

tdrdefknikasnleiesdmnesHQALTMFQISNWPSDGTTPN
                       ... . ..  .|| .|... 
.......................erlgiqylylpwpDhgvpdl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 162-269 1.5e-08 29.1 In-house 8-120 (239) alignment
Range on Protein: 162-269
Range on HMM: 8-120/239.0
NSWKNREGAGLPFDFNRVPLSKGSMG--NTYINASFVGC-LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLG-SVEE----EDEYWPDSEPleWY
|  |||    . .|..|| | | |    . |||||..    |    || ||  .. .| |||.|| . .  |.|.|   .|       .|||||     |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

eEDITVTLTDRDEFKN
  .. |||   . | .
.cnlrvtlrktevfad

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 162-269 1.7e-08 28.9 In-house 7-119 (239) alignment
Range on Protein: 162-269
Range on HMM: 7-119/239.0
NSWKNREGAGLPFDFNRVPLSKGSMG--NTYINASFVGC-LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLG-SVEE----EDEYWPDSEPleWY
|  |||    . .|..|| | | |    . |||||..    |    || ||  .. .| |||.|| . .  |.|.|   .|       .|||||     |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

eEDITVTLTDRDEFKN
  .. |||   . | .
.cnlrvtlrktevfad

Y_phosphatase Protein-tyrosine phosphatase 163-306 5.7e-30 99.8 Pfam-A 2-152 (235) alignment
Range on Protein: 163-306
Range on HMM: 2-152/235.0
SWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYEEDI
. |||    ||.|..|| |.. .  . ||||..|    .. ..|.||.|| .|  |||.|.....|.|.|.| |.||.     ..|||..|  . . .||
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTLT-DRD-EFKNIKASNLEIESDMNES-HQALTMFQISNWPsDGTTPNDH
.|.|. .   . |..  ..||.... .|| .. ...... ||| | ..|.. 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpesp

Y_phosphatase Protein-tyrosine phosphatase 163-306 5.7e-30 99.8 In-house 2-152 (235) alignment
Range on Protein: 163-306
Range on HMM: 2-152/235.0
SWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYEEDI
. |||    ||.|..|| |.. .  . ||||..|    .. ..|.||.|| .|  |||.|.....|.|.|.| |.||.     ..|||..|  . . .||
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTLT-DRD-EFKNIKASNLEIESDMNES-HQALTMFQISNWPsDGTTPNDH
.|.|. .   . |..  ..||.... .|| .. ...... ||| | ..|.. 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpesp

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 163-305 1.5e-14 48.4 In-house 41-207 (301) alignment
Range on Protein: 163-305
Range on HMM: 41-207/301.0
SWKNREGAGLPFDFNRVPLSKG----SMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWY
.  ||     ..| ||. |..     .. ..|||||..    .. ..| .| |.  | .|||..... ..  .|..   .|.      .|||.||  . .
kalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

EEDITVTLTDRDEFKN-----I-----KASN-------LEIESDMneSHQALTMFQISNWPSDGTTPND
.  .||||..   . .     .     ..||       ....||.  | . .. .|. .|| ||  .. 
fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrep

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 163-301 2.1e-12 41.5 In-house 34-179 (297) alignment
Range on Protein: 163-301
Range on HMM: 34-179/297.0
SWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTA--EYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLEWYEE
  |||    | .| .|| | ..  .. |||| .|      |   |||.| || .|  |||... |. |.|.|..  ..|.       |||...       
lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

DITVTLT--DRDEFKNIKASNLEIESDmNEShQALTMFQISNWPSDGT
|. |       |||.... ..|..    .|| . ..  |  .||  | 
dvvveflsstsdefdrviltelqliyr.ses.rvvrhvqflswpdhGv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 164-300 1e-12 42.2 In-house 50-188 (439) alignment
Range on Protein: 164-300
Range on HMM: 50-188/439.0
WKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEplEWYEEDITVTL
 |||     .||. || |    |     |||| ..        || || |  .|. |||....|...  .|.|  . |   ||| ..  | .  ||.|  
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywpsda..evcygdiavrv

TDRDEFKNI--KASNLEIESDMNESHQALTMFQISNWPSDG
    |. |   .  ..  | | .|  ...  |.   ||   
drnielpnyvirgfkvfnerdttekertvlqfhyiawpdkn

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 166-306 1.7e-15 51.8 In-house 24-172 (270) alignment
Range on Protein: 166-306
Range on HMM: 24-172/270.0
NREGAGLPFDFNRVPLSKGS--MGNTYINASFV-GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEP--LEWYEE
||    ||    || |.. .     .|||| .| |  |....|| .. ||. |  .||.|..|..|. .|..  .||.       ||| .    ..  . 
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledg

DITVTLTDRDEFKNIKASNLEIEsDMNESHQALtMFQISNWPSDGTTPNDH
.|.|. .     .   . .|..| .  |... .  |.  .|| .|  ... 
kikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreed

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 170-305 1.5e-81 265.2 In-house 1-130 (130) alignment
Range on Protein: 170-305
Range on HMM: 1-130/130.0
AGLPFDFNRVPlskgsmGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEPLEWYEEDITVTLTDRDEFKN
|.|.|...|..      |||||||||||.|||||||.||||||||||||||||||||.||||||||||||||||||||||||||||||.|||||||||||
aalefevsrlq......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdrdefkn

IKASNLEIESDMNESHQALTMFQISNWPSDGTTPND
|||||||||||.||||||||||||||||||||||||
ikasnleiesdlneshqaltmfqisnwpsdgttpnd

subfamily_eak_pd Subfamily eak 172-307 1.2e-08 28.8 In-house 61-200 (332) alignment
Range on Protein: 172-307
Range on HMM: 61-200/332.0
LPFDFNRVPLSKGSMG-NTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLG-----SVEEEDEYWPDSEPLEWYEEDITVTLTDRD
.|.|.. | |.   .  . ||||| .       .||||  .  |  . ||.|.||..   .| |       .|. | |.||    |.    . |.  .  
vpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefv

EFKNIKASNLEIeSDMNESHQALtMFQISNWPSDGTTPNDHF
. ....  .||. |  ||.|. |  ...  |    .   . |
krniletrllel.skGnethrvl.hykvfGwtettlpkyedf

0046846 (Phosphotyrosine protein) phosphatases II 184-307 1.4e-07 27.0 In-house 8-95 (176) alignment
Range on Protein: 184-307
Range on HMM: 8-95/176.0
GSMGNTYINASFVGClgrtAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEPLEWYEEDItvtltdrdefknikasnleiesdmne
  .. .||||... .    . .| ||.|| .| .||..|..| .....| | .  | . .. .  . |.....|                          
ldldldyinanlilg....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

shqaltMFQISNWPSDGTTPNDHF
       ..  .||  |. . ...
......qylhlpwpDhgvpdlell

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 185-233 5.3e-08 26.8 In-house 67-115 (347) alignment
Range on Protein: 185-233
Range on HMM: 67-115/347.0
SMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVV
   .|||||| .     . ||||||.|| ||  |||||.   .|  .| 
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_CG42327_pd Subfamily CG42327 187-309 3e-11 37.5 In-house 55-184 (319) alignment
Range on Protein: 187-309
Range on HMM: 55-184/319.0
GNTYINASFV-GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLEWYE--EDITVTLTDRDEFKNIKASNLEIE
 . |..||.| |     . || .| .| |.| |||... |.   |.| | .. |       ||.| .| |.  .   || ||| .|.  ..   | | . 
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllk

SDMNESHQALTMFQIsNWPSDGTTPNDHFIM
   .|  . || .   .|.  .   ..  ..
rvdkeesrelthywy.kwleaevPaeeaali

0043147 (Phosphotyrosine protein) phosphatases II 187-307 2.2e-08 29.5 In-house 4-84 (172) alignment
Range on Protein: 187-307
Range on HMM: 4-84/172.0
GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVeeedeywpdseplewyeeditvtltdrdefknikasnleiESDMNESHQ
|..|||||.. .   . ..| || ||  |  |||.|. |......| | .                                         . |.   ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpeller

ALTMFQISNWPSDGTTPNDHF
    ..  .||  |... ...
lgiqylylpwpDhgvpllell

0036282 (Phosphotyrosine protein) phosphatases II 187-305 6.9e-08 27.9 In-house 1-86 (174) alignment
Range on Protein: 187-305
Range on HMM: 1-86/174.0
GNTYINASFVGCLGRTAEYILTQHPLAdtsmdFWKMMLERHVNVLVVLGSVEEED-----EYWPDseplewyeeditvtltdrdefknikasnleiesDM
|..|||||...   .| ..|..|.|||     ||.|. | .....| | . .| .      |||.                                 ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

NESHQALTMFQISNWPSDGTTPND
.  ..    ..  .|| .|. . .
edlerlgiqylylpwpDhgvpdls

0051429 (Phosphotyrosine protein) phosphatases II 188-303 2e-09 33.0 In-house 4-137 (272) alignment
Range on Protein: 188-303
Range on HMM: 4-137/272.0
NTYINASFVGCLGR---TAEYILTQHPLADTSMDFWKMmLERHVNVLVVLGSVEEE-----DEYWP----------DSEPLEWYEEDITVTLTDRDEFKN
..||||..|| .||      ......||  |  |||..  | .... | | |.||      | |||          |... .    ...|||.    . .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

IKASNLEIESD-MNESHQALTMFQISNWPSDGTTP
.   .|...    ..    .....  .|| .|. .
yilrellltlllsagearevmhlhytdwpdhgvpq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 188-313 1.1e-06 22.9 In-house 59-193 (285) alignment
Range on Protein: 188-313
Range on HMM: 59-193/285.0
NTYINASFVGCLGRT-AEYILTQHPLADTSMDFWKMMLERHVNVLVVL-----GSVEEEDEYWPDS--EPLEWYEEDITVTLTDRDEFKNIKASNLEIES
  || ||..   |.  . || || || .|  |||.|. . ..  ...|     | ||.   |.|.   | ... . .||.|    .        .| .  
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

DMNESHQALTMF--QISNWPsDGTTPNDHFIMVEVT
  . | . | |   |.  || |  .|.|   |.|. 
tedasseplymnhvqvpwwp.dqlapedarpmiely

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 191-309 1.8e-10 35.0 In-house 78-203 (301) alignment
Range on Protein: 191-309
Range on HMM: 78-203/301.0
INASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYEEDITVTLTDRDEF--KNIKASNLEIESDMNE
| | ..   |..  .| || || .|| ||| |.   .|. .|.||   |.     .|| | . . .   .  ........    |.|.  .||.|   ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-SHQALTMFQISNWPSDGtTPNDHFIM
 . ...| .| |.|.  | .|. |  .
fatrtvthyqysewtdrg.vPkshael

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 204-306 8.8e-06 20.0 In-house 5-113 (198) alignment
Range on Protein: 204-306
Range on HMM: 5-113/198.0
EYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLEWYEEDITV---TLTDRDEFkNIKASNLEIESDMNESHQALTMFQISN
 || ||||| .|  |||.|. |     .|..   . . |     ||| .|        ..|   |.| . ..  | |  |  ..    | . .. .|.. 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdy.titaliltnnttappstreishyqfts

WPsDGTTPNDH
|  . ||||  
wk.ekttpnva

V-set Immunoglobulin V-set domain 310-393 3.5e-07 21.1 Pfam-A 4-108 (114) alignment
Range on Protein: 310-393
Range on HMM: 4-108/114.0
VEVTPDDPTVTYGSDVTLTCSHDdTiNAANLTIEWTTTASNTDLSSVA--------------------MTSDTS---STLTLSNVDLSRTGTYTCDVDDD
|. .|   ||  | .|||.|.   . . .. .| |    ....   ..                    ..|..|    .||..|. |. .|||||.| | 
vsqsprpvtvaeGgsvtLpCfys.s.sensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds

DGTIEGT
.. ..|.
nedvfga

I-set Immunoglobulin I-set domain 311-388 1.7e-08 26.1 Pfam-A 4-80 (90) alignment
Range on Protein: 311-388
Range on HMM: 4-80/90.0
EVTPDDPTVTYGSDVTLTCSHDDTinaANLTIEWTTTASNTDL-SSVAMTSDT-SSTLTLSNVDLSRTGTYTCDVDDDDG
. ...| .|. |..|.|.|.   .    .....|..  |..   ..| .| .  ..|||.|||. | .|.||| .    |
tqklkdvevseGesvelectveGe...pepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsag

Ig_2 Immunoglobulin domain 314-400 2.2e-08 26.0 Pfam-A 6-80 (80) alignment
Range on Protein: 314-400
Range on HMM: 6-80/80.0
PDDPTVTYGSDVTLTCSHDdtiNAANLTIEWTTTASNTDlssvamtsD-TSStLTLSNVDLSRTGTYTCDVDDDDGtIEGTDSIVLTV
. ...|| |..|||||. .   . .. .. |.   . ..          ..  | ..|| ..  ||||| .  . |  . ..|. .||
apptvvtegenvtLtCqap...gnptpkvqwykdgeels........qsqna.lfipnvsaedsGtYtCrasnseg.skqsnsvevtv

Ig_3 Immunoglobulin domain 316-381 1.7e-08 26.6 Pfam-A 9-71 (75) alignment
Range on Protein: 316-381
Range on HMM: 9-71/75.0
DPTVTYGSDVTLTCSHDDTINaaNLTIEWTtTASNTDLSSVAMTSDTSSTLTLSNVDLSRTGTYTC
 |||| |  |||||| ...    . || |.    .  |...  .|...||||.|.|. . .|||||
sptvtsggnvtLtCsaeggpp..pptisWy.ietppelqgsegssssestLtissvtsedsGtYtC

ig Immunoglobulin domain 322-383 1.9e-07 22.3 Pfam-A 1-64 (64) alignment
Range on Protein: 322-383
Range on HMM: 1-64/64.0
GSDVTLTCSHddTINAANLTIEWTTTASNTDLSSVAMTSDTSST----LTLSNVDLSRTGTYTCDV
||.||||||.    .  . .. |.   . . .|.   .......    ||..||  .  ||||| |
GssvtLtCsv..ssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv

I-set Immunoglobulin I-set domain 408-499 4.1e-12 37.7 Pfam-A 3-90 (90) alignment
Range on Protein: 408-499
Range on HMM: 3-90/90.0
ISISPPSPSVEYNNSTTITCQVTSLTTPNITWTTTaTAGITSQPVVLASSQGsdvYTSSLVLTGVTLDSIGSYTCTATNQGGSSNTTAMLNV
... . .  |. ..| ...|.|.   .|...|..     ..|.  |  . ..    ...|... |. .  |.|||.|||. |.....| |.|
ftqklkdvevseGesvelectveGepepsvsWakd.gselkssqrvkvtvee...aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_2 Immunoglobulin domain 410-501 4.4e-10 31.5 Pfam-A 4-80 (80) alignment
Range on Protein: 410-501
Range on HMM: 4-80/80.0
ISPPSPSVEYNNSTTITCQVTSLTTPNITWTTTAtAGITSQPVVlassqgsdVYTSSlvltgVTLDSIGSYTCTATNQGGsSNTTAMLNVTV
.|.|...|. . . |.|||...  ||...|.    . .....          .....     |...  |.|||.|.|..| |... ...|||
lsapptvvtegenvtLtCqapgnptpkvqwykdg.eelsqsqna........lfipn.....vsaedsGtYtCrasnseg.skqsnsvevtv

Ig_3 Immunoglobulin domain 411-486 3.4e-10 32.0 Pfam-A 7-75 (75) alignment
Range on Protein: 411-486
Range on HMM: 7-75/75.0
SPPSPS-VEYNnsTTITCQVTSLT-TPNITWTttatagiTSQPVVLASSQGSDVYTSSLVLTGVTLDSIGSYTCTATN
||..   .. |   |.||....   .|.|.|.        ..| .| .|.||. . |.|....|| .  |.|||.|.|
spsptvtsggn..vtLtCsaeggpppptisWy.......ietppelqgsegssssestLtissvtsedsGtYtCvasN

ig Immunoglobulin domain 420-484 1.5e-06 19.5 Pfam-A 1-64 (64) alignment
Range on Protein: 420-484
Range on HMM: 1-64/64.0
NNSTTITCQV-TSLTTPNITWTTTATAGITSQPVVLASSQGSDVYtsSLVLTGVTLDSIGSYTCTA
..|.|.|| | .    ....|.   .  ..||..   .  .|  .  .| .. || .  |.|||..
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe..vLtinnvtkedsGtYtCvv

Ig_3 Immunoglobulin domain 503-578 5e-08 25.0 Pfam-A 1-74 (75) alignment
Range on Protein: 503-578
Range on HMM: 1-74/75.0
PPSVSIPDDNVTITYGMnLTLDCTVSSVFLPLTVEWR-FGQMVIKTMNYTSAPTGPLQVSvtSVTGSNAGVYTCVAT
.|..|..  ..... |  .|| |.. . . | |. |   . ..... ...|   . | .|  ||| .. |.|||||.
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtis..svtsedsGtYtCvas

I-set Immunoglobulin I-set domain 504-592 5.2e-09 27.8 Pfam-A 1-90 (90) alignment
Range on Protein: 504-592
Range on HMM: 1-90/90.0
PSVSIPDDNVTITYGMNLTLDCTVSSVfLPLTVEWRFGQMVIKT---MNYTSAPtGPLQVSVTSVTGSNAGVYTCVATHDHGTDSDNVNVIV
|..... ..|... | ...|.|||. .  ...|.|  ..  .|.   ...|    .  .  ...|. |..| |||.||   |... .... |
pkftqklkdvevseGesvelectveGe.pepsvsWakdgselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_2 Immunoglobulin domain 512-592 5.8e-10 31.1 Pfam-A 8-80 (80) alignment
Range on Protein: 512-592
Range on HMM: 8-80/80.0
NVTITYGMNLTLDCTVSsVFLPLTVEWRFGQMVIKtmnytS---AptgplqVSVTSVTGSNAGVYTCVATHDH-GTDSDNVNVIV
....| | |.|| |...  . . .| |. .   ..     .   |      . . .|. ...|.|||.|. .. .. |. |.| |
ptvvtegenvtLtCqap.gnptpkvqwykdgeels.....qsqna......lfipnvsaedsGtYtCrasnsegskqsnsvevtv

ig Immunoglobulin domain 518-577 5.6e-07 20.8 Pfam-A 1-64 (64) alignment
Range on Protein: 518-577
Range on HMM: 1-64/64.0
GMNLTLDCTVSSVFLPLTVEWRFGQMVIKTMNYTSAPTGPLQ----VSVTSVTGSNAGVYTCVA
|...|| |.|||   . .| | ... . .. ..|   .   .    . ...|| ...|.||||.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv

I-set Immunoglobulin I-set domain 600-691 1.1e-13 42.8 Pfam-A 3-90 (90) alignment
Range on Protein: 600-691
Range on HMM: 3-90/90.0
LTITPTSLSVNHSDTATFTCTVTSLTTPNITWTTTaTAGITSQPNVLASSQGsdmHTSSLVLTGVILDSIGSYTCTATNEGGSIDTTAMLNV
.|...... |.  ......|||.   .|...|..     ..|. .|  . ..    ...|... |  .  |.|||.|||. |.  ..| |.|
ftqklkdvevseGesvelectveGepepsvsWakd.gselkssqrvkvtvee...aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_2 Immunoglobulin domain 601-693 1.4e-08 26.7 Pfam-A 3-80 (80) alignment
Range on Protein: 601-693
Range on HMM: 3-80/80.0
TITPTSLSVNHSDTATFTCTVTSLTTPNITWTTtATAGITSQPNVlassqgsdMHTSSlvltgVILDSIGSYTCTATNEGGSIDTTAMlNVTV
...... .|. ... |.||....  ||...|.   .. .....|         .....     | ..  |.|||.|.|..||. .. . .|||
vlsapptvvtegenvtLtCqapgnptpkvqwyk.dgeelsqsqna........lfipn.....vsaedsGtYtCrasnsegskqsnsv.evtv

Ig_3 Immunoglobulin domain 606-678 4.8e-09 28.3 Pfam-A 10-75 (75) alignment
Range on Protein: 606-678
Range on HMM: 10-75/75.0
SLSVNH-SdtATFTCTVTSLT-TPNITWTttatagiTSQPNVLASSQGSDMHTSSLVLTGVILDSIGSYTCTATN
.  ..  .   |.||....   .|.|.|.        ..|..| .|.||.   |.|....|  .  |.|||.|.|
ptvtsggn..vtLtCsaeggpppptisWy.......ietppelqgsegssssestLtissvtsedsGtYtCvasN

Ig_2 Immunoglobulin domain 700-787 8.7e-07 20.9 Pfam-A 4-80 (80) alignment
Range on Protein: 700-787
Range on HMM: 4-80/80.0
LTPPTLEIYYNTTLKLNCTVFSVTTPTINWTTTANITIPIENIvtmntgnmyksvLTIDNVDLNYTGLYTCSSTN-QGGTESDVSNVTV
|..|  ..  .... |.|.. .  ||.. |.   ... . .|.            | | || ... | |||. .| .|.. |.  .|||
lsapptvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvevtv

I-set Immunoglobulin I-set domain 702-787 1.5e-11 35.9 Pfam-A 7-90 (90) alignment
Range on Protein: 702-787
Range on HMM: 7-90/90.0
PPTLEIYYNTTLKLNCTVFSVTTPTINWTTTaNITIPIENIVTMNTGNmYKSVLTIDNVDLNYTGLYTCSSTNQGGTESDVSNVTV
.  .|.  .....|.|||  . .|...|..  .  .  .. |...  .  .. |||.||. . .| |||  ||. |...   ...|
lkdvevseGesvelectveGepepsvsWakd.gselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_3 Immunoglobulin domain 710-774 5.8e-07 21.6 Pfam-A 17-75 (75) alignment
Range on Protein: 710-774
Range on HMM: 17-75/75.0
NttLKLNCTVFSVT-TPTINWTttaniTIPIENIVTMNTGNMYKSVLTIDNVDLNYTGLYTCSSTN
|  ..|.|....   .||| |.       .  .. . .  . . |.||| .|. ...| |||  .|
n..vtLtCsaeggpppptisWy.....ietppelqgsegssssestLtissvtsedsGtYtCvasN

Ig_2 Immunoglobulin domain 796-879 2.7e-08 25.7 Pfam-A 4-72 (80) alignment
Range on Protein: 796-879
Range on HMM: 4-72/80.0
ITSSPmKYVTYADTLSIMCNVTsLMRPSSIVWYHNDTLISSGAQPnftatgapntytsVLVrDNVVLRDNGVYRCQAENMAG-IG
....|  .||  ... ..| ..    . .. ||......|..                ...  || . |.|.|.|.| |  | . 
lsapp.tvvtegenvtLtCqap.gnptpkvqwykdgeelsqsqna.............lfi.pnvsaedsGtYtCrasnsegskq

I-set Immunoglobulin I-set domain 804-886 4.9e-09 27.9 Pfam-A 12-89 (90) alignment
Range on Protein: 804-886
Range on HMM: 12-89/90.0
VTYADTLSIMCNVTSLMRPsSIVWYHNDTLISSGAQPNFTATGapntYTSVLVRDNVVLRDNGVYRCQAENMAGIGAANINIS
|.  ..... |.|.    | |. |..... ..|  . ..|...     .. |. .||  .|.| |.|.|.| ||   |.....
vseGesvelectveGepep.svsWakdgselkssqrvkvtvee....aeytLtIsnvevsDeGkYtckatnsagkaeakaeLk

Ig_2 Immunoglobulin domain 1111-1189 2.4e-08 25.9 Pfam-A 8-78 (80) alignment
Range on Protein: 1111-1189
Range on HMM: 8-78/80.0
EenSTAILGDKFMFRCDPDySNPRPHLQISKiltNGTELNlyTGQSKLHSiMNVAFDDAGNYRCVLTNDY-GRTESNFQL
   ...  |... ..|  . .|| | .| .|   .|.||.  ..|..|..  ||  .|.|.|.|...|.  . . . ...
p..tvvtegenvtLtCqap.gnptpkvqwyk...dgeels..qsqnalfi.pnvsaedsGtYtCrasnsegskqsnsvev

I-set Immunoglobulin I-set domain 1160-1191 3.9e-06 18.6 Pfam-A 59-90 (90) alignment
Range on Protein: 1160-1191
Range on HMM: 59-90/90.0
SIMNVAFDDAGNYRCVLTNDYGRTESNFQLIV
 | ||  .|.|.|.|. || .|. |....| |
tIsnvevsDeGkYtckatnsagkaeakaeLkV

fn3 Fibronectin type III domain 1197-1279 1e-06 21.9 Pfam-A 2-85 (85) alignment
Range on Protein: 1197-1279
Range on HMM: 2-85/85.0
QVTGVTVTYLSFFEILFRWNVPSSNFGRDQRYNVEYRLLLAEA-SSSNITGLTDPSYLLTDVALNVNYSVVVSSNNEVGRGPPS
......|.  .  .. ..|. |... | ...|.||||    .  . .  .  | .|. ||.   . .|.. | . |..| ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 1297-1387 6.1e-06 19.5 Pfam-A 4-75 (85) alignment
Range on Protein: 1297-1387
Range on HMM: 4-75/85.0
TNLSSSNINNTinpSIQVKWEPLSpeDGSEFLQRYIVRVNVTDLAAsrgsrrrrqtnpvmTTLEYNVSNAESQFDFTDIKPFMSYSIGVNA
.||| |....|   |....|.| .  ||.. ...| |..  ..                  . |..|.. .... .|..|| ..|.. | |
enlsvsevtst...sltlsWsppk..dgggpitgYeveyrekggge..............ewkeftvprtttsvtltgLkpgteYefrVqa

fn3 Fibronectin type III domain 1415-1495 8.8e-15 47.8 Pfam-A 2-84 (85) alignment
Range on Protein: 1415-1495
Range on HMM: 2-84/85.0
APTNFRFTEINFTYVQLAWDPPEPQNGIINLYQIDWERGGRGD-SIRSILPDIR-SIRVSGLTGDVTYTFKIKAQTSAGFGNE
||.|....|.. |...| |.||....| |  |.....  | |. . .  .|    |  ..||. . .|.|...|.. || | |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe