Gene PGP in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP165_AA protein Get Run
AqueP165_AA_19-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Chronophin_1 20-293 1e-76 248.8 In-house 2-256 (261) alignment 
Range on Protein: 20-293
Range on HMM: 2-256/261.0
ETVLLDCDGVLWLGNTdAIPGAKEAVSHLRALGKRLCFVTNNSSKSRDEYMAKFQKLGFD-VNKSEIFPTGYIVGQYLKHtAGYDGKVYLMGVEGTKQEI
..||||.||||. |.. |.|||.|... |.  ||.. ||||||.. |.|. |....||.| |.. ||| . .   ..|.. .  ..|||..| || ..|.
qlvLlDldGVlikgee.avpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq.qaakakvyvlGeeglrkel

EAIGCTCFGPGPDvltgtlddwlqmsfekDVGAVVVAYDCHISYMKMIQACTYLKNPdCIFIATNEDPVLPSNGHiAIPGTGSMVSAVRTSAKRDPIIVG
.. | .. .   |                .| |||| || ..|..|. .|....... . |.|||.||  | .    .|||||.. ||.. ..|.|..||
reaGlrlvdeped................rveaVvvGydeelsfeklaeaialirdg.alfvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvvG

KPHTPMFDCIVKHTNLQPHKTLMIGDSLNTDILFGRRHGLKTLLVLSGNTKECNLEGLSSDKLPDYYADSIADLI
||.. ||..........|..|.|.|| |.||||.|.| ||.|||||.| ... ...   .|  ||....|||||.
KPepvmfeealekigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqaykkdlrPdavvesiadll
Hydrolase haloacid dehalogenase-like hydrolase 20-257 2.2e-14 45.7 Pfam-A 2-215 (215) alignment 
Range on Protein: 20-257
Range on HMM: 2-215/215.0
ETVLLDCDGVLWLGNTDA-IPGAKEAVSHLRAL--------GKRLCFVTNNSSK--SrDEYMAKFQKLGFDVNKSEIfptgyivgqYLkhtaGYDGKVYL
 ||. |..|.|. |.     .|.|.|   ..||        || . ... ..|   .  ...|.| . |   . ..|         .|    | .  .  
ktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrgg.ltgfatfigrgvsgkvdgi.........vl....gnpewmta

MGVE-GTKQEIEAIGctCFGPGPDVLTGTlddwlqmsfekdvgAVVVAYDCHIS---YMKMIQACTYLKNPDC-IFIATnEDPVLPSNGHIAIPGT-GSM
.|..   . ...|.|   . ....| ...              .... .. ...   . ....|. .||   . ....|  |   . .   . .|  .|.
lglrviapdlvaaeg..qskgrtvvvvav..............qaralgviafadpvkpeaaeavasLkeaGievvllt.gdnpetaeaiakqagiedsl

VSAVRTsakrdpiivGKPHTPMFDCIVKHTNLQPHKTLMIGDSLnTDILFGRRHG
| |  .         |||.  .|  ...  ...|....|.||.. .|. .... |
vfaevv.........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
subfamily_PGP_pd Subfamily PGP 21-293 1.8e-111 362.9 In-house 1-276 (279) alignment 
Range on Protein: 21-293
Range on HMM: 1-276/279.0
TVLLDCDGVLWLGNTdAIPGAKEAVSHLRALGKRLCFVTNNSSKSRDEYMAKFQKLGFD-VNKSEIFPTGYIVGQYLKHtAGYDGKVYLMGVEGTKQEIE
|||.|||||||||.| |||||.||...|..|||...|||||| |||.|.. ||.||||. |...||. ..... .|||. . ...|||..| ||.|.|..
tvlfDcDGVlWlget.aipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq.kkfekkvyvlgeeglkeeLk

AIGCTCFGPGPDVLTGTLD--DWLQMSFEKDVGAVVVAYDCHISYMKMIQACTYLKNPDCIFIATNEDPVLPSNGHIAIPGTGSMVSAVRTSAKRDPIIV
. |....| ||. |...||   . .....||||||||..|...||.|...|..||..|...|.||||| .|| . .. |||.||.|.|......|.|...
eagiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvl

GKPHTPMFDCIVKHTNLQPHKTLMIGDSLNTDILFGRRHGLKTLLVLSGNTKECNLEGLSS--DKLPDYYADSIADLI
|||...............|..||||||.|.||||||...||.|||||||.||....| ...  .. ||||.||.|||.
GKPnelllelllekeeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkeeklvPdyyldsladll
Chronophin_2 21-293 1.1e-75 245.5 In-house 2-277 (282) alignment 
Range on Protein: 21-293
Range on HMM: 2-277/282.0
TVLLDCDGVLWLGNTdAIPGAKEAVSHLRALGKRLCFVTNNSSKSRDEYMAKFQKLGF-DVNKSEIFPTGYIVGQYLKHTAGYDGKVYLMGVEGTKQEIE
.||.|||||.| |.. |..|| | ||.|  .||.  ||||||...|..|. || .||| ||.. .|| . |   .||...|   |||. .| || ..|..
nvlfdcdgviwngek.avagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadvrgkvfviggeglrkelr

AIGCTCFGPGPDVLtGTLddwLQMSFEKDVGAVVVAYDCHISYMKMIQACTYLKNPDCIFIATNEDPVLPSNGHIAIPGTGSMVSAVRTSAKRDPIIVGK
. |  . .   .    ..   .. . . || ||.| || .....|. .||.||...||...||..||  | ..   .||.||. .|. |.. |  ...||
eagvpvvedadeqe.asi...ydcaldpdvravlvgydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigk

PHTPMFDCIVKHTNLQPHKTLMIGDSLNTDILFGRRHGLKTLLVLSGNTKECNLE-------GLSSDKLPDYYADSIADLI
|   ||.|| .. ...| ..||||| |.|||||| . ||.|.| |.| ..  . .           |  |||. .|||||.
psrfmfecissqfsvdparslmigdrletdilfgsncglstvltltgvssleeaqeysdsqlaeqrdlvpdyvvesiadll
subfamily_LHPP_pd Subfamily LHPP 22-267 4e-34 109.5 In-house 1-220 (227) alignment 
Range on Protein: 22-267
Range on HMM: 1-220/227.0
VLLDCDGVLWLGNTdAIPGAKEAVSHLRALGKRLCFVTNNSSKSRDEYMAKFQKLGFDVNKSEIFPTGYIVGQYLKHTAGydgKVYLMGVEGTKQEIEAI
||||  |||. ... ||||| ||. .||. |... ||||.. .|. . ... ..|||||...||| .. .. |.|...     . ||.  .......|.|
vllDlsGvlhneda.aipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerkl...rpyllveddveedfedi

GCTCfgPgpdvltgtlddwlqmsfekdvGAVVVAY-DCHISYMKMIQACTYLKN-PDCIFIATNEDPVL-PSNGhIAIpGTGSMVSAVRTSAKRDPIIVG
 .    |                      |||..  . ...| .. ||   |.. ..   || |.. .   ..|  |. | |. |.|.. ... .  .||
dtdk..p.....................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lal.gpGafvkaleyatgvkaevvG

KPHTPMFDCIVKHTNLQPHKTLMIGDSLNTDILFGRRHGLKTLLVLSGN
||.  .|.  .......|.. .||||... |.    . ||...|| .| 
KPsalffekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGk
Hydrolase_6 Haloacid dehalogenase-like hydrolase 22-123 8.9e-30 94.1 Pfam-A 1-100 (101) alignment 
Range on Protein: 22-123
Range on HMM: 1-100/101.0
VLLDCDGVLWLGNTdAIPGAKEAVSHLRALGKRLCFVTNNSSKSRDEYMAKFQKLGFDVNKSEIFPTGYIVGQYLKHTaGYDGKVYLMGVEGTKQEIEAI
.|.|.||||| |.. |||||.||.  ||| ||.....|||||||..||..|..|||.||...... ... . .||| .   |.||...| || ..|... 
flfDvdGvLwrgdk.aipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkr.kadkkvlvigeeglreelkea

GC
| 
Gf
Acid_phosphat_B HAD superfamily, subfamily IIIB (Acid phosphatase) 33-83 1.1e-06 16.5 Pfam-A 113-163 (230) alignment 
Range on Protein: 33-83
Range on HMM: 113-163/230.0
GNTDAIPGAKEAVSHLRALGKRLCFVTNNSSKSRDEYMAKFQKLGFDVNKS
|. .|||||.| . ... .|  . ||.. | ..... .....| ||. .. 
geakaipgalelikkvverGvkiffvsgRseeqkaaTvenLkkagfsswek
Hydrolase_like HAD-hyrolase-like 217-292 2.3e-18 57.3 Pfam-A 2-75 (75) alignment 
Range on Protein: 217-292
Range on HMM: 2-75/75.0
VGKPHTPMFDCIVKHTNLQPHKTLMIGDSLNTDILFGRRHGLKTLLVLSGNTKECNLEGlsSDKLPDYYADSIADL
 |||.  |.| . .  .. | ...||||||.|||..... |....|||.|...|  |.   .   |||..|.....
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl..akakpdyvvddleea
HAD_2 Haloacid dehalogenase-like hydrolase 217-263 1.7e-06 19.7 Pfam-A 131-176 (176) alignment 
Range on Protein: 217-263
Range on HMM: 131-176/176.0
VGKPHTPMFDCIVKHTNLQPHKTLMIGDSLnTDILFGRRHGLKTLLV
. ||.  ... ........|. .|.|.|||  |.  .|  |..| .|
apKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv