Gene PTPRN in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP401_AA protein Get Run
AqueP401_AA_33-285 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRN_pd Subfamily PTPRN 22-141 6.2e-40 131.7 In-house 2-124 (297) alignment 
Range on Protein: 22-141
Range on HMM: 2-124/297.0
NVPANANIDINAGHLLLTYIENNLRDKGRLDKEWESLTSYAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLPR
. |. .|.|| .||..|.|.|. |..| ||.||||.|..|  .. . ... . .| .|||. ..|||||.|| |..| .|. |||||| .|.| ||. | 
eepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa

YIASQGPLQHTITDFWQS---QG
|||.|||| .|..||||    ||
yiatqgplastvadfwqmvweqG
0045450 (Phosphotyrosine protein) phosphatases II 26-271 1e-54 181.7 In-house 4-300 (307) alignment 
Range on Protein: 26-271
Range on HMM: 4-300/307.0
NANIDINAGHLLLTYIENNLRDKGRLDKEWESLTSYAPD-DVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNA-SGSDYINANFITDV-------D
. .. |.| .||| . .. | .. .| ||.|.| |. ..   . ...|...||.||||.|||||||||| |. . .  ..||||||.....         
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

PKLPRYIASQGPLQHTITDFWQS-----------------------------------------------QG----------------Sslnvlhpssdn
 .  ..|| ||||..|. |||.                                                .                 .           
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg...........

ddedggdnysesvqYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTL--PQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKE--INLAGAVEH
              .|||.|.|||..|     | .. .||||...|..|.    ...||||||| |||||||.|.... |... .. .   ..|  ||..
..............esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkl

LRDQRKQMVKTKSQFEFALDAL
||.|| ..| . .|..|  .||
lreqRpgavqnpeqyrflyeal
0051299 (Phosphotyrosine protein) phosphatases II 29-272 4.8e-60 198.8 In-house 3-283 (288) alignment 
Range on Protein: 29-272
Range on HMM: 3-283/288.0
IDINAGHLLLTYIENNLRDKGRLDKEWESLTSYAPDdVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGP
 .|.. .|| .. .  .... .| .|.| |.|. || ....|.|  .|..||||.|||||||.|| |. . . .|||||||..| |. ..  ..|| |||
teisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgP

LQHTITDFWQ---SQGSSLNVLHPSSDNDDEDGGDNYSE-------------------------------------SVQYSRTITQFHYLSWSVAAPPAN
|..|. |||.    |.... |   . ....    . |                                         ..|||.|.|||..|     | .
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

PTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALV
|..||||.|.|..|.  ...||.|||| |||||||.|..|. |...  . ..... .||..|| || .|| | .|..|  .||.
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0039614 (Phosphotyrosine protein) phosphatases II 29-273 9e-56 184.9 In-house 12-287 (297) alignment 
Range on Protein: 29-273
Range on HMM: 12-287/297.0
IDINAGHLLLTYIENNLRDKGRLDKEWESLTSYAPDdvsVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNA-SGSDYINANFITDVDPKLPRYIASQG
|.|  ..| | .  ... .|..|..|.|.| |. ||    . .|. .||.||||.|||||||.|| |. | .   .||||||....  |   ...||.||
ipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLQHTITDFWQS----QGSSLNVLHPSSDN-----------------------------------------DdedggdnysesvqYSRTITQFHYLSWSV
||..|. |||.     . ...  | .  ..                                         .             .|||.|.|.|..|  
PlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnng.............esrtvthfqytgwpd

AAPPANPTPLLDFWRKVKTAYTL--PQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQ
  .| ... ||.| ..|..|.    .. ||||||| |||||||.|.... |... .. .....  ||..|| || ..| | ||..|  |||..
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 31-271 1.5e-54 180.7 In-house 2-273 (278) alignment 
Range on Protein: 31-271
Range on HMM: 2-273/278.0
INAGHLLLTYIENNLRDKGRLDKEWESLTSYAPddVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQ
|.  .|| ...| .| .| .| .|.|.|.|. .   . . .|...||.||||.|||||||.|| |. . .  .||||||... |. .. ...||.||||.
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

HTITDFWQS----QG--------------------------------------------------------SslnvlhpssdnddedggdnysesvqYSR
.|. |||.     .                                                         .                         .||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdg.........................esr

TITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQRKQMVKTKSQFEFALDA
|.|..|||.|     | ....|||| ..|..|.  ...||||||| |||||||.|.... |... ..  ...|  ||..|| || ..| | ||..|  .|
tvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyea

L
|
l
0040438 (Phosphotyrosine protein) phosphatases II 36-273 4.1e-57 189.2 In-house 5-274 (317) alignment 
Range on Protein: 36-273
Range on HMM: 5-274/317.0
LLLTYIENNLRDKGRLDKEWESLTSYAPDdvSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITD
|||..   ...|...| .|.| | |. .|  . . .. ..||.||||||||||||.|| |. . .  .||||||... |.  . ...|| ||||..|. |
lllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntved

FWQ----SQGSSLNVLHPSSDNDD-------------------------------------------EdggdnysesvqYSRTITQFHYLSWSVAAPPAN
||.     . ...  | .. ....                                           .           .|||.|.|||..|    .| .
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgds...........esrtvthfhytgWpdhgvpps

PTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQ
|..|||| ..|..|.  |..||||||| |||||||.|.... |...  .  ....  ||..|| || ..| | .|..|  ||| .
pdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 39-138 8e-16 53.1 In-house 11-107 (305) alignment 
Range on Protein: 39-138
Range on HMM: 11-107/305.0
TYI-ENNLRDKGRLDKEWESLTSYaPDDVSVkaGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFW
.|| |..  ..  |.....||..  .. . |  | . .||.|||. .| ..|. |. |... .   ||||||...   . |  .||..||||..|..|||
ayikearvysdkgleaqykslyee.eesidv..gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfW

Q
.
r
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 39-116 2e-11 37.9 In-house 13-87 (440) alignment 
Range on Protein: 39-116
Range on HMM: 13-87/440.0
TYIENNLRDKGrLDKEWESLTSYApDDVSVKAGLSlNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVD
 |..|| | .   . ||  | |    . | .|.|  ||| |||| .|| |||.||.|..      |||||| .|. ..
dyvqnnrrsra.fedewsllpsgl.sqpsdiaslp.nnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
0047943 (Phosphotyrosine protein) phosphatases II 40-271 6.1e-56 185.2 In-house 3-268 (273) alignment 
Range on Protein: 40-271
Range on HMM: 3-268/273.0
YIENNLRDKGRLDKEWESLTSYAPdDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLnkefNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ-
.. ..| ....| .|.| |.|. | ... ...|  .||.||||.|||||||.|| |    . .|||||||... |. .. ...|| ||||..|. |||. 
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrm

---SQGSSLNVLHPSSDNDDEDGGDNYSE-----------------------------------SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVK
    . . . .| .  ... |.    ...                                   . ..|||.|.|||..|     |.....||.|...|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

TAYTL--PQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDAL
.|.     ..||.|||| |||||||.|..|. |...  . .....  || .||.||  || | .|..|  .||
kalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyeal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 40-114 1.1e-09 32.3 In-house 4-76 (244) alignment 
Range on Protein: 40-114
Range on HMM: 4-76/244.0
YIENNLRDKGRLDKEWESLTSYAPDDVSVKAGLSLNnKHKNRYPDILPYDHTRVLLNKEfNASGSDYINANFITD
|  . |.|.    .|. .|. .. . . ..| || |   |||| .|||.|.|||.|.   .  ||||||||.|  
yevsrlqdeevakeefvglsdhtreflqtnavlsan.atknryinilpfdetrvilsss.kkegsdyinanyiqg
0036941 (Phosphotyrosine protein) phosphatases II 41-273 8.2e-57 188.1 In-house 5-275 (297) alignment 
Range on Protein: 41-273
Range on HMM: 5-275/297.0
IENNLRDKGRLDKEWESLTSYAPdDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLnkefNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ--
. ..| .. .| ||.|.|... . . | ...|...|..||||.|||||||||| |    . .|||||||... |.     ..|| ||||..|. |||.  
llekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmv

--SQGSSLNVLHPSSDNDDEDGGDNYSES------------------------------------VQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVK
   . ... .| .  ... |     ...                                      ..|||.|.|||..|    .| .|..||||...|.
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

TAYTL--PQSPVLVHCSEGVGRTGTYILIDMTLSRITS--GAKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQ
... |  ...||||||| ||||.||.|..|. |... .    .....  || .||.|| ..| | .|..|  .|| .
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
subfamily_PTPN14_pd Subfamily PTPN14 41-139 1e-18 62.4 In-house 16-112 (300) alignment 
Range on Protein: 41-139
Range on HMM: 16-112/300.0
IENNLRDkGRLDKEWESLTSYAPdDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNAsGSDYINANFIT-DVDPKLPRYIASQGPLQHTITDFWQS
.|..|.. |.. .|.| ..     |  ....   .|..|||..|.|||...|| |.   ..  ..||||  |   |  |   ||..||||..|..|||| 
lekklee.gkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqm
subfamily_PTPN6_pd Subfamily PTPN6 42-138 4.3e-25 83.3 In-house 19-116 (306) alignment 
Range on Protein: 42-138
Range on HMM: 19-116/306.0
ENNLRDKGRLDKEWESLTSY-APDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNkEFNASGSDYINANFIT-DVDPKLPRYIASQGPLQHTITDFWQ
|..  .|  . .|.|.|    | . .| | |   .||.||||  |||.||||| |. | . .||||||||.|. .|  .  .|||.|| |..|..|||.
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 42-138 6.9e-21 69.9 In-house 27-122 (319) alignment 
Range on Protein: 42-138
Range on HMM: 27-122/319.0
ENNLRDKGRLDKEWESLTSYAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
..   |. .|  |.  ..  ...    .     .|| |||. .||..|...| |..     .|||||| |.|    |  .|||.||||. |. |||.
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrk.dkyiaaqGPldntladfWr
0050432 (Phosphotyrosine protein) phosphatases II 43-278 1.1e-58 194.3 In-house 36-302 (308) alignment 
Range on Protein: 43-278
Range on HMM: 36-302/308.0
NNLRDKGRLDKEWESLTSYAPdDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLnkefnASGSDYINANFITDVD-PKLPRYIASQGPLQHTITDFWQ---
... |.|.|..|.| |.|. | . . ...|  .||.||||.|||||||.|| |      .|||||||....  .  .  ..|| ||||..|. |||.   
ekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

-SQGSSLNVLHPSSDNDDEDGGDNYSES-----------------------------------VQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTA
  . .   .|    .|. |     . ..                                    ..|||.|.|||..|     | .|..||||...|.. 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

YtlPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQETQYM
.  |..|..|||| |||||||.|..|. |...  . ..... .|| .|| || .|| |..|..|  .||.   ...
l..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_PTPN23_pd Subfamily PTPN23 43-138 6.8e-25 82.4 In-house 9-101 (288) alignment 
Range on Protein: 43-138
Range on HMM: 9-101/288.0
NNLRDKGRLDKEWESLTSYAPDDV-SVKAGLSLNNKHKNRYPDILPYDHTRVLLNkefnASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
. | .|. |||... |...   .  .    ..  . .|||. |||||||.|| |.     |  ||||| |. |. |  | .||.|.||| |. |||.
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl
subfamily_PTPRB_pd Subfamily PTPRB 43-138 4.3e-23 76.8 In-house 19-112 (293) alignment 
Range on Protein: 43-138
Range on HMM: 19-112/293.0
NNLRDKGRLDKEWESLTSYAPDDvSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
.. ... |. .|.|.| .   |  .|||  .  |. |||| .||||||.|| |..  . |||||||||.| .   .   .||.|||| .|. |||.
mkadsdlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 44-138 1.5e-20 68.2 In-house 5-98 (287) alignment 
Range on Protein: 44-138
Range on HMM: 5-98/287.0
NLRDKGRLDKEWESLTSYA-PDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEfNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
..| |  .||| . |.  .    .  ||   | . .|||| |.||.|.||||| .|    ||||||||...    .  ..||.|||.  |. |||.
errvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 44-138 1.2e-16 55.5 In-house 15-109 (290) alignment 
Range on Protein: 44-138
Range on HMM: 15-109/290.0
NLRDKGRLDKEWESLTSyAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNA--SGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
. . . .  .....| | .  . .|. ||. .||..||. .|..||  |. |..  .      .|||| .| .   |  .||| |||...|. |||.
hakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWk
subfamily_PTPN9_pd Subfamily PTPN9 45-138 1.6e-19 65.0 In-house 13-103 (297) alignment 
Range on Protein: 45-138
Range on HMM: 13-103/297.0
LRDKGrLDKEWESLTSYAPDDVSVKAGLSlNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDpKLPRYIASQGPLQHTITDFWQ
 . .| | ||.. . . ..     .. |   | .|||| |.| ||.||| |.|. . . ||||||||.     .   .|| ||||..|..|||.
kgkrG.lskeyaeirnepveGtflasklr.anleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 46-274 3.1e-35 116.3 In-house 17-235 (392) alignment 
Range on Protein: 46-274
Range on HMM: 17-235/392.0
RDKGRLDKEWESLTsyAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLpRYIASQGPLQHTITDFWQSQ----G
|    . .|.  |    ||    ...    |..|||| .||||| .|| |.   . . |||.|| .|  .| .   |||||||   .. |||.       
rhsalffeefhdlp..gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek.ayiasqgpnaaslddfwrmvfqenv

SSLNVLHPSSDNDdedggdnyseSVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITsGAKEI
... ..    . |            .  ||..|||.  |  .  |   . || | ..||. .     |...||| ||||||  | ||  ...    .. .
ttiamvtklkegd..........kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahak.ktrmv

NLAGAVEHLRDQRKQMVKTKSQFEFALDALVQE
..   |  .| .|  ||.|| |. |   |....
dvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_PTPRD_pd Subfamily PTPRD 46-138 6e-29 96.1 In-house 20-109 (564) alignment 
Range on Protein: 46-138
Range on HMM: 20-109/564.0
RDKGRLDKEWESLTSYapDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDpKLPRYIASQGPLQHTITDFWQ
 .. ....|......   . ....|     ||.|||| .|..|||.|| |.|  . .|||||||.||   . |   |||.||||..|| |||.
nsdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWR
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 46-138 9.1e-25 82.3 In-house 18-108 (288) alignment 
Range on Protein: 46-138
Range on HMM: 18-108/288.0
RDKGRLDKEWESLTSYAPDDvSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDvDPKLPRYIASQGPLQHTITDFWQ
|..  . .|..||..   .. ||.||   .|..||||..|||||..|| |.|  . .|.|||||..| . . |  .|||.||||..|. |||.
rnrtgfseeynsLaalektk.svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWe
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 46-138 1.2e-18 62.1 In-house 21-110 (315) alignment 
Range on Protein: 46-138
Range on HMM: 21-110/315.0
RDKGRLDKEWESLTSYAPDDVSVkaGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDpKLPRYIASQGPLQHTITDFWQ
  |  . ...||.       . |      .||.|||| .|..||..|| |    | ..|||.|||||   . |  ||||.|||.  .. |||.
stkngfkqdyesipggqlhpldv..akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 47-138 7.4e-23 76.1 In-house 21-109 (319) alignment 
Range on Protein: 47-138
Range on HMM: 21-109/319.0
DKGRLDKEWESLTSYAPDdvSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
 .  |.||.. |    .|  ...     .||.||||..||.||.||| | .  .  |||||||.||   . .  ..|| |.||..|| |||.
getllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWr
subfamily_Ptp69D_pd Subfamily Ptp69D 47-138 1.2e-21 72.1 In-house 19-109 (307) alignment 
Range on Protein: 47-138
Range on HMM: 19-109/307.0
DK-GRLDKEWESLTSYaPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
|    | ||.|.| .    | | |..   .|. ||||.|| ..|.||| |.|      ||||||.||   . |  ..||.|.|.. || |||.
dtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWR
subfamily_PTPN13_pd Subfamily PTPN13 47-138 1.7e-19 65.2 In-house 9-95 (273) alignment 
Range on Protein: 47-138
Range on HMM: 9-95/273.0
DKGRLDKEWESLTSYAPDDVsVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNasgsdYINANFIT-DVDPKLPRYIASQGPLQHTITDFWQ
|..  ..|.. |    | |  .. | . .||.|||| ..||||.||| |..| .     ||||..|   |. .  .|||.|||| .|..||||
dqqqPaeefkelrelkpldt.cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 47-138 1.1e-14 49.1 In-house 4-90 (267) alignment 
Range on Protein: 47-138
Range on HMM: 4-90/267.0
DKGRLDKEWESLTSYAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNAsgsdYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
..  ..||.| ..  ...   .   .. .|. .||. | ||||.||| | .. .     |||| ..     |   .|. |.||. |||||..
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktk.nafivtqdplkntitdflt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 48-138 6.3e-24 79.7 In-house 26-117 (298) alignment 
Range on Protein: 48-138
Range on HMM: 26-117/298.0
KGRLDKEWESLTSYAP--DDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLpRYIASQGPLQHTITDFWQ
  ....|.. |.|     .. . ... . .||.||||.||...|..||.|.|| .   |||||| |.   . .   .||.|.||..|..|||.
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWr
subfamily_PTPN3_pd Subfamily PTPN3 48-138 3e-21 70.6 In-house 14-102 (280) alignment 
Range on Protein: 48-138
Range on HMM: 14-102/280.0
KGRLDKEWESLTSYAPDdVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKefnaSGSDYINANFIT-DVDP--KLPRYIASQGPLQHTITDFWQ
.|.. ...| |    |. ....|    .| .|||| ||||||.||| |..    | .||||||..  ...      ||||.||||..| |||||
sGavlaqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWq
subfamily_PTPRG_pd Subfamily PTPRG 48-138 3.2e-21 70.2 In-house 18-109 (563) alignment 
Range on Protein: 48-138
Range on HMM: 18-109/563.0
KGRLDKEWESL-TSYAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGS-DYINANFITDVDpKLPRYIASQGPLQHTITDFWQ
. ....|.|.| .  ...|. ...    .||.|||| .|..||..|| |..  .  .. ||||||.|     |   .||.||||..|. |||.
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 48-138 1.2e-13 45.4 In-house 14-103 (301) alignment 
Range on Protein: 48-138
Range on HMM: 14-103/301.0
KGRLDKEWESLTSYAPDDVSVkaGLSLNNKHKNRYPDILPYDHTRVLLNKEFN--ASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
. ........|... ..  .|  ||| .||. ||. .| .||. |..|... |   .  .||||..| ..  |  ..||.|||...|..|||.
snkfeeqykelkegedksctv..glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWr
subfamily_PTPRA_pd Subfamily PTPRA 49-138 9.2e-21 69.0 In-house 32-119 (330) alignment 
Range on Protein: 49-138
Range on HMM: 32-119/330.0
GRLDKEWESLTSYaPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
 .. .|...| .  | . ....    .||.|||...|||||..|| |..      |||||| ||     |  ..||.|||...|. |||.
klfreefnalPag.piqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 50-138 3.3e-25 83.8 In-house 21-107 (318) alignment 
Range on Protein: 50-138
Range on HMM: 21-107/318.0
RLDKEWESLTSYAPDDVSVKAgLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ
 |..|.| |.       |.|. |.  ||.|||| .||.||||||.|..  .  ||||||||.| |   .   |||.|.|| .||.|||.
llseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 50-138 8.4e-14 46.3 In-house 17-100 (307) alignment 
Range on Protein: 50-138
Range on HMM: 17-100/307.0
RLDKEWESLTSYAPDDVSVKAGLSlnNKHKNRYPDILPYDHTRVLLNkeFNASGSDYINANFI-TDVDPKlpRYIASQGPLQHTITDFWQ
.|  |.. |. ..|. |.|.|  .  | .|||| |.   |..|....  |.   |||| ||.. . ..||  ..|..||||. |. .|| 
alvdefrvlakktpegvtveafsa..ntdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpk..kficaqgplentqysfwa
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 50-127 1.3e-09 32.2 In-house 24-95 (95) alignment 
Range on Protein: 50-127
Range on HMM: 24-95/95.0
RLDKEWESLTSYApdDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEfnaSGSDYINANFITDVDPKlPRYIASQG
 .|.|. |..  .    .  .| |  |  |||. .|.||| ||| |        |||||| |.     |   |||.||
efdnefksismts..gapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyark.ncyiaaqg
0046845 (Phosphotyrosine protein) phosphatases II 51-277 1.7e-56 187.0 In-house 2-276 (284) alignment 
Range on Protein: 51-277
Range on HMM: 2-276/284.0
LDKEWESLTSYAPDDV-SVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNA-SGSDYINANFITDVD----PKLPRYIASQGPLQHTITDFWQS---QG
|..|.| |.|. .. . |....| ..|..||||.|||||||.|| |. . .  ..||||||....  |     . ...|| ||||..|. |||.    |.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SSLNVLHPSSDNDDEDGGDNYSE-----------------------------------SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYT--
... |   . ....    . |                                       ..|||.|.|||.||     |..|..||.|.|.|.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

LPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAK--EINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQETQY
 ...|..|||| |||||||.|..|. |...  .    .... .|| .||.|| .|| | .|..|  .||.   ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 51-138 6.5e-25 83.3 In-house 2-87 (263) alignment 
Range on Protein: 51-138
Range on HMM: 2-87/263.0
LDKEWESLTSYAPDDvSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ
|..| |.| ...... ... .   .||.|||| .||||||||| |.|| . .||||||||.| ... |  .||| ||||..|. |||.
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyi.kgankkkkyIatQgPlpstvedFWr
PTPc_SM00194 51-138 6.5e-25 83.3 In-house 2-87 (263) alignment 
Range on Protein: 51-138
Range on HMM: 2-87/263.0
LDKEWESLTSYAPDDvSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ
|..| |.| ...... ... .   .||.|||| .||||||||| |.|| . .||||||||.| ... |  .||| ||||..|. |||.
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyi.kgankkkkyIatQgPlpstvedFWr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 51-138 3.9e-20 67.1 In-house 17-102 (281) alignment 
Range on Protein: 51-138
Range on HMM: 17-102/281.0
LDKEWESLTSYAPDDVSvKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
. .|.|.|..   |... .|  . .|..|||| .|  ||.||| .... ... .|||||||.  .. .  .|||.|||. .....|||
fieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykge.keyiatqgPvPaslvafWq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 51-138 4.6e-17 56.8 In-house 21-105 (315) alignment 
Range on Protein: 51-138
Range on HMM: 21-105/315.0
LDKEWESLTsyAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLpRYIASQGPLQHTITDFWQ
. .|.  |    ||    ...   .| .|||| .|||.|..|| |.   .   |||||| .|  ||     ||||||||. .. |||.
fseefhdlp..dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddk.ayiasqgPlkasvddfwr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 51-138 9.2e-13 42.4 In-house 22-109 (439) alignment 
Range on Protein: 51-138
Range on HMM: 22-109/439.0
LDKEWESLTSYAPDDVSVKAGL-SLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITD-VDPKLprYIASQGPLQHTITDFWQ
.....|.. |  ||   . . .    .. |||| |. ..||||| |..      | |||||.|    |.||  |||.||| ..|  |||.
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl..yiatqgpkkettddfwr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 51-137 4.6e-10 33.6 In-house 26-113 (305) alignment 
Range on Protein: 51-137
Range on HMM: 26-113/305.0
LDKEWESLTSYAPDDV---SVKAGLSLN-NKHKNRYPDILPYDHTRVLLNKefnASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFW
| .|. .|. |.  |.    ..|  | . .. |||| |.   |.. |.|.|    | |||| ||..        |.|..||||..|| .||
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldk...pspsdyihanyvgcpmipekrficaqgpldqtidefw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 51-141 7.5e-09 29.7 In-house 21-103 (312) alignment 
Range on Protein: 51-141
Range on HMM: 21-103/312.0
LDKEWESLTSYAPDDvSVKAglSLNNKHKNRYPDILPYDHTRVLLNKEFNAsgsdYINANFITdVDPKLPRYIASQGPLQHTITDFWQSQG
| ||. ..    .|   . |   |. |  ||||.|  .|  |  |  . |     || |||.  .  |  |....||||. |.| |||   
ltkeykavgnivsds.ecta..flkfkdlnrypniqcwdrgrftlagdenf....yihanfvk.ictkperfvctqgplentcthfwqlal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 52-138 4.7e-10 33.6 In-house 14-99 (281) alignment 
Range on Protein: 52-138
Range on HMM: 14-99/281.0
DKEWESLTSYAPDDVSVKAGLSLNNKhKNRYPDILPYDHTRVLLNK-EFNASGSDYINANFITDvdPKLPR-YIASQGPLQHTITDFWQ
 .|.  |    | |.       .||| |||| .|   | .|| |.    |   .||| ||.|    | | | || .||| . | .|||.
kqefsnlpgdppsdlctvfnqpvnnk.knrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 52-138 4.7e-06 20.8 In-house 22-100 (288) alignment 
Range on Protein: 52-138
Range on HMM: 22-100/288.0
DKEWESLTSYAPDDVsvkAGLSLNNKHKNRYPDILPYDHTRVLLNkefnASGSDYINANFITdVDPKLPRYIASQGPLQHTITDFWQ
.||..     |. |.   .   ..|  ..|| ..   | ||| |.         ||.|| ..   .   | | .| ||. ||  .|.
kkeyrdspneasidi...idsfianptrdryenlprcditrvkls....ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 53-138 2e-11 38.1 In-house 26-101 (303) alignment 
Range on Protein: 53-138
Range on HMM: 26-101/303.0
KEWESLTSYAPDDVSVKAglSLNNKHKNRYPDILPYDHTRVLLnkefnaSGSDYINANFItDVDPKlPRYIASQGPLQHTITDFWQ
.|.| ..|| | .|| .    ..| .|||. |..  ||..| |      | | || |... ..| .  . | .| ||.|| .||||
nefekvvsylppsvsknq..fvknmdknrfvdvicldhskvkl......sdssyihasyl.eldss.kkailtqlplshtaadfwq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 56-138 3.1e-15 50.9 In-house 27-104 (287) alignment 
Range on Protein: 56-138
Range on HMM: 27-104/287.0
ESLTSYAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNkefnASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
  | .   .. .|  ... .||.|||. .||..|  ||||.        ||||| ||     |  ..|....|. .|. .||.
tvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfntarnfWk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 57-138 2.4e-06 21.3 In-house 20-103 (347) alignment 
Range on Protein: 57-138
Range on HMM: 20-103/347.0
SLTSYAPDDVSVKAglSLNNKHKNRYPDILPYDHTRVLLNKEFNASG-----SDYINANFITdVDPKLPRYIASQGPLQHTITDFWQ
 |..|.| .....     ..  |||  |    | |||.|  |    .       ||||  |   |     || .| || .|. |||.
nlanyspskftsve..wekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwk
0049772 (Phosphotyrosine protein) phosphatases II 58-274 3.7e-35 117.5 In-house 28-279 (314) alignment 
Range on Protein: 58-274
Range on HMM: 28-279/314.0
LTSYAPDDVSVKAGLSLNNKHKNRYPDILPYDhTRVLLnKEFNASGSDYINANFITDVdpklPRYIASQGPLQHTITDF----------WQSQ-------
..  .. . .....  . |..||||.||||.| .|| | . .. ||||||||...  .     ..||.||||..|. ||          |.         
rslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnv

--------------------------------------GSSLNVLHpssdnddedggDNYSESVQYSRTITQFHYLSWSVAAPPaNPTPLLDFWRKVKTA
                                       . |  |.           . . .   ..|.. ..... ..   .|  .  ...| . ...|
rdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........eelydpelferlgikylripvpDgsap.lledfdeflefieea

ytLPQSPVLVHCSEGVGRTGTYILIDMTLSRItsgakEINLAGAVEHLRDQRK-----QMVKTKSQFEFALDALVQE
   ...||||||. |.|||||...... ...       ..|. |.|..| .|       ....  |.|| |.|| . 
..dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 59-138 1.5e-10 35.2 In-house 38-112 (290) alignment 
Range on Protein: 59-138
Range on HMM: 38-112/290.0
TSYAPDDVSVKAGLSLNN-KHKNRYPDILPYDHTRVLLNKEFNasgSDYINANFITDVDPklpRYIASQGPLQHTITDFWQ
  | | .   .  .  |   .|||| |.   | |||.|.  ..    ||. ||..  ...    .| .||.|. |. |.|.
kpylpvqylerkifdkntefkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlka...mfiltqGalkdtvidiwr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 60-138 1.1e-13 45.7 In-house 17-93 (283) alignment 
Range on Protein: 60-138
Range on HMM: 17-93/283.0
SYAPDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNasgsDYINANFIT--DVDPKLPRYIASQGPLQHTITDFWQ
  .  | ...   . .||.|||. .|.|.|  || |. | .    ||||| ||.  . . .  .||..|.||..|. |||.
rlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 62-156 8e-18 59.3 In-house 35-140 (350) alignment 
Range on Protein: 62-156
Range on HMM: 35-140/350.0
APDDVSVKAGLSLNnkHKNRYPDILPYDHTRVLLN--------KEFNASGSDYINANFIT------DVDPKLpRYIASQGPLQHTITDFWQSQGSSLNVL
  .|| .  |. |    |||| .||||.|.|| |.        |.   |..||||||..       ...|.  .||| |.||. |. ||..      . .
psnDvilseGvelf..aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf.kYiatqaPlpstvddfykvillnkvkv

HPSSDNDDE
  |  .|.|
ilsltsdve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 62-140 8.4e-12 39.1 In-house 36-127 (349) alignment 
Range on Protein: 62-140
Range on HMM: 36-127/349.0
APDDVSVKAGLSLNnkHKNRYPDILPYDHTRVLLNKEFNASG--------------SDYINANFI--TDVDPKLpRYIASQGPLQHTITDFWQSQ
  ||| .  |. |    |||| |||||.|.|| |.|  ..|                ||||||..  | ....  .||| | ||  |. ||..  
eiddvilseGvelf..aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek.kyiatqaPlPstvddfykvi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 63-138 1.4e-17 58.8 In-house 35-109 (325) alignment 
Range on Protein: 63-138
Range on HMM: 35-109/325.0
PDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
 | .. |.    .|| |||.......|..|| |.   ... ||||||... |   |   ..|.| || .|| |.|.
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 63-152 3.2e-10 34.0 In-house 83-170 (244) alignment 
Range on Protein: 63-152
Range on HMM: 83-170/244.0
PDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEfnASGSDYINANFITDVDpKLPRYIASQGPLQHTITDFWQSQ-GSSLNVLHPSSD
||   .|  .. || .|||    ||.|  || |.|   . |  |||| |.  .  .   || .| ||  |  |||.      .|||     
pdpsvmkdafnpnnswknregaglpfdfnrvplskg..smgntyinasfvgclg.rtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs
subfamily_egg_pd Subfamily egg 63-138 5.8e-09 30.0 In-house 27-101 (307) alignment 
Range on Protein: 63-138
Range on HMM: 27-101/307.0
PDDVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDvDPKLPRYIASQGPLQHTITDFWQ
 |..|..  .| ||..| | . .   | .|| |. .      |.| || .   .| |  .| .| ||. |  |||.
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwr
subfamily_PTPN1_pd Subfamily PTPN1 65-138 1.6e-17 58.2 In-house 21-89 (290) alignment 
Range on Protein: 65-138
Range on HMM: 21-89/290.0
DVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNasgsDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ
|.....    .|. .||| |. ||||.|. |... |    |||||... ...    .|| .|||| .|.. |||
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslv.eleeakrsyiltqGPlpntvdhfWq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 65-138 1.7e-13 44.8 In-house 41-112 (310) alignment 
Range on Protein: 65-138
Range on HMM: 41-112/310.0
DVSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEfNASGSDYINANFITDvDPKLPRYIASQGPLQHTITDFWQ
| |.      .. ||||| |..  | .|| |. . ..   ||| ||..   .     .| ||||||||| |||.
dssltyeaykkymhknrysdvvcldtsrvklkid.ksryedyihanyvkt.nylrstficsqgplqhtiidfwr
0045098 (Phosphotyrosine protein) phosphatases II 66-273 6.5e-50 165.4 In-house 23-270 (278) alignment 
Range on Protein: 66-273
Range on HMM: 23-270/278.0
VSVKAGLSLNNKHKNRYPDILPYDHTRVLlnkefnasgsDYINANFITDVdPklPRYIASQGPLQHTITDFWQ---SQGSSLNVLHPSSDNDDEDGGDNY
 ..  .| |.|..||||.|||||||.||           |||||..|.   |  ...|| ||||..|. |||.   ..|..  |   .   ..    . |
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

-------------------------------------SESVQYSRTITQFHYLSWSVAAPPANP--TPLLDFWRKVKTAYTL-------------PQSPV
                                      ..  .||..|..|||.|    .| .|  ...|.... .. |. |             .. ||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LVHCSEGVGRTGTYILIDMTLSRItsGaKEINLAGAVEHLRDQRKQ-MVKTKSQFEFALDALVQ
||||| |||||||...... |...  . . ..|  ||..|| || . .| ...|..|  ..|..
lVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPN12_pd Subfamily PTPN12 66-138 4.8e-25 83.0 In-house 30-101 (290) alignment 
Range on Protein: 66-138
Range on HMM: 30-101/290.0
VSVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLpRYIASQGPLQHTITDFWQ
.| .|| . .|..|||| ||||||..|| |.|. .  ||||||||||  |. || .|||.|||| .|..|||.
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkl.eyiaaqgPLpktlddfWr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 67-137 1.8e-10 35.1 In-house 39-105 (305) alignment 
Range on Protein: 67-137
Range on HMM: 39-105/305.0
SVKAGLSLNNKHKNRYPDILPYDHTRVLLNKEFnasGSDYINANFITD-VDPKlpRYIASQGPLQHTITDFW
 .||    ....|||| |.   |. || |.  .     .|| ||...   .||  |.| .| ||..| .|||
kmkafkeaqeagknrykdvgcldnnrvklegpw...pheyihanyvstptnpk..rfictqaplektcadfw
subfamily_CG7180_pd Subfamily CG7180 69-138 2.7e-14 47.5 In-house 35-103 (296) alignment 
Range on Protein: 69-138
Range on HMM: 35-103/296.0
KAGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVdPKLPRYIASQGPLQHTITDFWQ
..|| ..|. |||.....|||..||.|.|    . |||||| ..     |   ||  ..| ..|. .||.
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsf.lkkkeyivteapkketvdefWr
0040439 (Phosphotyrosine protein) phosphatases II 70-272 1.3e-46 154.6 In-house 5-243 (249) alignment 
Range on Protein: 70-272
Range on HMM: 5-243/249.0
AGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQS---QGS-SLNVLHPSSDNDDEDgGDNYSE-
 .| ..||.||||||||||||.|| |.   .  .||||||..| |.    .|.|| ||||..|. |||.    .|. ..  | .   .. |.  . |   
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrek.caqywpl

--------------------------------SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTL--PQSPVLVHCSEGVGRTGTYILIDMT
                                  . |||.....|..|     | .. .||||...|..|..   ...||||||| |||||||.|.... 
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALV
|...    ....|  ||..||.|| ..| . .|..| ..|| 
leqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 70-271 3.2e-46 153.2 In-house 4-238 (243) alignment 
Range on Protein: 70-271
Range on HMM: 4-238/243.0
AGLSLNNKHKNRYPDILPYDHTRVLLnkefnaSGSDYINANFITDVdpklPRYIASQGPLQHTITD----FW----QSQGSSLNVLHPSSDNDDEDGGDN
 .|...|..||||.|||||||.|| |      .||||||||.|. .    ||.||.||||..|. |    ||    . . ...  | .  ... |.    
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

Y-------------------------------SESVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTA--------YTLPQSPVLVHCSEGVGRTG
.                                .  ...|.....|||.|    .| .|..||||...|..         .  ...||||||| ||||||
wpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TYILIDMTLSRItsgakEINLAGAVEHLRDQRKQ-MVKTKSQFEFALDAL
|.|.... |...     ...|  ||..||.|| . .| | ||..|  .||
tliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_ptpA1_pd Subfamily ptpA1 70-138 2.1e-17 58.0 In-house 41-107 (418) alignment 
Range on Protein: 70-138
Range on HMM: 41-107/418.0
AGLSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlpRYIASQGPLQHTITDFWQ
 |    |  |||| .||| .|||| |.|  .  ||||||||.|    ||  ..|..||||  ||.|||.
egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwr
0042113 (Phosphotyrosine protein) phosphatases II 72-271 5.6e-47 155.6 In-house 5-239 (245) alignment 
Range on Protein: 72-271
Range on HMM: 5-239/245.0
LSLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQS---QGSSLNVLHPSSDNDDEDGGDNYSE----
| ..||.||||.|||||||||| |. . .  .||||||... |..   |..||.||||..|. |||.    .|..  |   . . ..  . . |      
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

-----------------------------SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYT-LPQSPVLVHCSEGVGRTGTYILIDMTLSRI
                                .||.....|||.|    .| ..  |||| . |..|.   .. ||||||| |||||||.|.... |...
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

TSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDAL
 .  ....|  ||..||.|| ..| | ||..|  .||
eke.lgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 73-138 1.1e-20 68.9 In-house 6-70 (250) alignment 
Range on Protein: 73-138
Range on HMM: 6-70/250.0
SLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
 ..||.|||| ||...|..||.|.||     |||||| |.   | .   .||.|||||.|| |||.
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWr
subfamily_PTPRK_pd Subfamily PTPRK 73-138 2.5e-16 54.4 In-house 40-104 (314) alignment 
Range on Protein: 73-138
Range on HMM: 40-104/314.0
SLNNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQ
  .|..|||. |||.||..|| |    . . ||||||..| |   .   .|. |||||.|..|||.
kdenreknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 75-138 4.5e-20 67.3 In-house 24-86 (284) alignment 
Range on Protein: 75-138
Range on HMM: 24-86/284.0
NNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQ
.|| |||. .||..|...| |..     .|||||| |||    |  .|||.||||. |. |||.
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrk.dkyiatqGPldntladfWr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 75-138 9.8e-20 65.8 In-house 27-91 (274) alignment 
Range on Protein: 75-138
Range on HMM: 27-91/274.0
NNKHKNRYPDILPYDHTRVLLNKEFNASG-SDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
 ...|||| .||| ...||||..| . .  |.|||||.|   | .   |.| ||||..|..|||.
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 75-138 4.7e-17 56.9 In-house 19-82 (270) alignment 
Range on Protein: 75-138
Range on HMM: 19-82/270.0
NNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
..|. ||| ||||  .||| |... . | . |||||..  .| .  .|||..|||. |...||.
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 75-138 7.2e-17 56.4 In-house 2-63 (237) alignment 
Range on Protein: 75-138
Range on HMM: 2-63/237.0
NNKHKNRYPDILPYDHTRVLLNKefNASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
.|| |||| .|  |||.||.|.   . ||||||||... ..|    .|||.||||. .  ||||
enkiknrygnivaydhsrvvlkg..agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 75-138 1.8e-15 51.8 In-house 7-70 (239) alignment 
Range on Protein: 75-138
Range on HMM: 7-70/239.0
NNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
 || |||| .|. |||.||.|.|  |   ||||||... | |     |||.|| .. .  |||.
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwr
subfamily_CG42327_pd Subfamily CG42327 75-138 4.4e-09 30.4 In-house 27-90 (319) alignment 
Range on Protein: 75-138
Range on HMM: 27-90/319.0
NNKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
  | |.|. ...|  .||| |..  .   . |..|...   |     |||.| .|. . .|||.
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 75-138 1.6e-07 25.5 In-house 34-93 (285) alignment 
Range on Protein: 75-138
Range on HMM: 34-93/285.0
NNKHKNRYPDILPYDHTRVLLNKEfnasGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
 |   ||| |.   . |||.|..       ||| |...         ||..||||  |..|||.
anpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwh
0041856 (Phosphotyrosine protein) phosphatases II 76-273 2.2e-34 114.0 In-house 1-169 (182) alignment 
Range on Protein: 76-273
Range on HMM: 1-169/182.0
NKHKNRYPDILPYDHTRvllnkefnasGSDYINANFITDVDPKlPRYIASQGPLQHTITDFWQSQG-----SSLNVLhpssdndD-------Edggdnys
|..||||.|||||||.|          ..||||||..    |   |.|| ||||..|. ||..        . .|.        .       .       
nldknrysdilpydhsr..........dldyInanlylgslpa.trfiatqgpllstvadflrmlkelgittivnlt.......eelywpell.......

esvqySRTITQFHYLSWSVAAPPAnPTPLLDFWRKVKTaytlPQSPVLVHCSEGVGRTGTYILIDMTLSRitsgakEINLAGAVEHLRDQRKQMVKTKSQ
      |...|..||.|    .|  .  |||| ..|.     .. ||||||| |||||||...... ...      ...|  ||...| .| .|| | .|
.....erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklvrsrRpgmvitpnq

FEFALDALVQ
. |  .|| .
yfflqlalle
Y_phosphatase Protein-tyrosine phosphatase 76-138 1.1e-20 69.4 Pfam-A 1-60 (235) alignment 
Range on Protein: 76-138
Range on HMM: 1-60/235.0
NKHKNRYPDILPYDHTRVLLnkEFNASGSDYINANFITDVDpKLPRYIASQGPLQHTITDFWQ
||.||||.||||||.||| |  . . . |||||||...  . .  ..||.||||..|| |||.
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWr
Y_phosphatase Protein-tyrosine phosphatase 76-138 1.1e-20 69.4 In-house 1-60 (235) alignment 
Range on Protein: 76-138
Range on HMM: 1-60/235.0
NKHKNRYPDILPYDHTRVLLnkEFNASGSDYINANFITDVDpKLPRYIASQGPLQHTITDFWQ
||.||||.||||||.||| |  . . . |||||||...  . .  ..||.||||..|| |||.
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 76-138 1.6e-15 51.2 In-house 43-104 (515) alignment 
Range on Protein: 76-138
Range on HMM: 43-104/515.0
NKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLpRYIASQGPLQHTITDFWQ
| .|||| .||||| .|| |.   ..  |||.|| .|  .|     |||||||.. .. |||.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndk.ayiasqgPnkasvddfWr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 76-138 2e-15 51.6 In-house 7-69 (239) alignment 
Range on Protein: 76-138
Range on HMM: 7-69/239.0
NKHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPKLPRYIASQGPLQHTITDFWQ
|| |||| .|. |||.||.|.|  |   ||||||... | |     |||.|| .. .  |||.
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 76-138 2.3e-15 51.5 In-house 48-110 (297) alignment 
Range on Protein: 76-138
Range on HMM: 48-110/297.0
N---KHKNRYPDILPYDHTRVLLNKEFNASGSDYINANFITDVDPklpRYIASQGPLQHTITDFWQ
.    .|.|| .|||||  || |.   .   |||.|| |.  .     |.|..| | . |. |||.
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 77-138 5.2e-15 50.1 In-house 34-94 (297) alignment 
Range on Protein: 77-138
Range on HMM: 34-94/297.0
KHKNRYPDILPYDHTRVLLNKEfnASGSDYINANFITDVDPKLP-RYIASQGPLQHTITDFWQ
 .|||| ||| .| ||| | .    ...|||||....  | . . .|| .||||. |. |||.
lrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwt
0044763 (Phosphotyrosine protein) phosphatases II 87-267 9.5e-22 72.9 In-house 1-163 (178) alignment 
Range on Protein: 87-267
Range on HMM: 1-163/178.0
PYDHTRVLLNKEFNASGSDYINANFITDVdpklpRYIASQGPlqhtiTDFWQ---S--QGSSLNVLHPSS-------DNDDEDGGdnysesvqysrtiTQ
|.|.|||||..  .  .||||||..|..       |..|..|      |...       .. .|. ..           . |. |              |
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............iq

FHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRitsgakEINLAGAVEHLRDQRKqMVKTKSQFEFA
.... ..   .|  .  .|.| . ...|.  ...||||||| ||||.|| ..... ...       ..|  |.|..| .|  .| . .| .. 
ylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivpnpgqlrqL
0043147 (Phosphotyrosine protein) phosphatases II 102-268 1.6e-28 95.0 In-house 3-154 (172) alignment 
Range on Protein: 102-268
Range on HMM: 3-154/172.0
SGSDYINANFItDVDPKLPRYIASQGPLQHTITDFWQS---QGSSLnVLHP--SsdnddedggdnYSESVQYSRTITQFHYLSWSVAAPPaNPTPLLDFW
.|||||||... |.  . .|.|| ||||..|. |||.    .| .. ..                .    ...|.. |..||.|    .| ..  ||.| 
egsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgith.ivnltel...........lydpellerlgiqylylpwpDhgvp.llelllefl

RKVKT-AYTLPQSPVLVHCSEGVGRTGTYILIDMTLsritsgaKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
. ... .   |. ||||||| ||||||| ..... |       . ..|  ||...|..| ..| ..||  | .
efidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 103-278 4.4e-26 87.6 In-house 3-228 (272) alignment 
Range on Protein: 103-278
Range on HMM: 3-228/272.0
GSDYINANFITDVdpklPR------YIASQGPLQHTITDFWQSQGSSLNVL-----------------------HPSSDNDDEDGGDNYSE---------
 |.||||...        |      ...|.|||..|. |||. .   ...                        .  . .||..   .|           
lsgyiNardvggy....grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

----------------SVQYSRTITQFHYLSWSVAAPPANPtpLLDFWRKVKTaytlpQSPVLVHCSEGVGRTGTYILIDMTLSRItSGAKEIN------
                | . .|.....||..|     | ..  ||.. . . .     . ||||||| |..||||...... | .. |    ..      
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgv.sletivddYlltn

--LAGAVEHLRDQRKQMVKTKSQFEFALDALVQETQYM
  |..|||.||.|| ..| |  |..| ..||..   ..
lyleeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 103-267 3.8e-24 80.7 In-house 1-162 (174) alignment 
Range on Protein: 103-267
Range on HMM: 1-162/174.0
GSDYINANFItDVDPKLPRYIASQGPLQhtITDFWQSQGSSLNVLHPSSDNDDEDGGDNYSE----SvqYSRTITQFHYLSWSVAAPPANPTpLLDFWRK
|||||||... |.   .||.||.||||.    ......|..  |   ..  ..  .  ||      .  ..|.. |..|| |    .|  .. ||.| . 
gsdyinaspl.dlsyitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelred..lerlgiqylylpwpDhgvpdlsi.llefvkf

VKTAYTL-PQSPVLVHCSEGVGRTGTYILIDMTLSRITsgAKEINLAGAVEHLRDQRKQMVKTKSQFEFA
|..|.   |. ||||||| ||||||| ..... | ..    . ..    |  || || .|| | ||..| 
veealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrfl
0046846 (Phosphotyrosine protein) phosphatases II 103-270 1.2e-21 72.7 In-house 11-168 (176) alignment 
Range on Protein: 103-270
Range on HMM: 11-168/176.0
GSDYINANFITDvdpklPRYIASQGPLQHTITDFWQSQGSS----------------------------LNVlhpssdnddedggdnysesvqysrtitQ
..||||||.|       .|.|| |||| .|. ||..   .                             |..                           |
dldyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................q

FHYLSWSVAAPPANpTPLLDFWRKVKTAYTLPqSPVLVHCSEGVGRTGTYILIDMTLSRitsgaKEINLAGAVEHLRDQRK-QMVKTKSQFEFALDA
...| |    .|   . ||.. . ...|..    ||||||| |.|||||......  ..     | ...  |....|.||  ..| | .| .|  ..
ylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQyrflyef
0051082 (Phosphotyrosine protein) phosphatases II 104-270 2e-22 74.8 In-house 3-148 (151) alignment 
Range on Protein: 104-270
Range on HMM: 3-148/151.0
SDYINANFITDVdpklprYIASQGPLQHTITDFWQSQGSSLNVLHPSSDNDdedggDNYSESVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTay
|||||....|.       ...|.|||.. .  ... . ..   | .   ..      ...   ...........|.|..   | ..  .|.|....    
sdyinfsyvtgg......lyrsggpladflellkelgiktivnlrseeerg.....ycpeylpelgievlhipildwpdpglplsfdavleflellld..

tLPQSPVLVHCSEGVGRTGTYILIDMTLSRitsgakeINLAGAVEHLRDQRKQMVKTKSQFEFALDA
  .. ||||||| |.||||| ..... | .       ..|. |.|..| .|  .| .. || | | |
.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 120-268 4.4e-22 73.8 In-house 9-143 (152) alignment 
Range on Protein: 120-268
Range on HMM: 9-143/152.0
PRYIASQGPLQHTITDFWQ---SQGSSLNVLHPSSDNDDEDGGDNYSesvqysrtitQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSE
 ..|| |||. .|. |||.   ..| .  |   . . ..... ..|           |...| |    .| ..  ||.. . .. ..  .. ||||||| 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsa

GVGRTGTYILIDMTLsritsgaKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
|||||||...... |       . ..|  ||...| .|...| ...| .| .
GvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPDC1_pd Subfamily PTPDC1 157-267 8.9e-08 26.8 In-house 68-168 (182) alignment 
Range on Protein: 157-267
Range on HMM: 68-168/182.0
DGGDNYSESVQYSRTITqFHYLSWSVAAPpANPTPLLDFWRKVKtaYTLPQSPVLVHCSEGVGRTGTYILIDMTLSritsgaKEINLAGAVEHLRDQRKQ
..|  |.      . |. .. ..|.     |  . .||  . |.  ..| .  | |||  | ||||  |   .  .      |... . |.. .|..| .
esGfsYdlealmeqgiy.vynfgwkDygv.asleriLdivkvva..falqegkvavhChaGlGrtGvliacylvya......krltaekaiklvrskrpk

MVKTKSQFEFA
 ..|..| |. 
siqtreqvelv
PTEN_1 158-225 6.8e-06 21.0 In-house 81-148 (196) alignment 
Range on Protein: 158-225
Range on HMM: 81-148/196.0
GGDNYSESVQYSRTITQFHYLSWSVAAPpaNPTPLLDFWRKVKTAYTL-P-QSPVLVHCSEGVGRTGTYI
.| .|...  . . ... |.      ||  .   |.|. .... .. . | .  |||||  |.||.|| .
sgrsydleeffksgveylhfpieDhgap..slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Ptp69D_pd Subfamily Ptp69D 161-277 2.6e-25 84.2 In-house 173-288 (307) alignment 
Range on Protein: 161-277
Range on HMM: 173-288/307.0
NYSESVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKT
. |  |. || ..|.||..|     |  .. ||.. ..|.  | | .||..|||| ||||.|... .|. | ..    .....   | .|| ||. .|. 
eesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqs

KSQFEFALDALVQETQY
  |..|   ||.. ..|
leqYvflyralldyssy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 163-271 4e-13 43.9 In-house 155-262 (283) alignment 
Range on Protein: 163-271
Range on HMM: 155-262/283.0
SESVQYSRTITQFHYLSWSVAAPPANPTPLLDFwRKVKTAYT-LPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQRKQMVKTK
. | . .  .. . .  |    . |    |. |  ||..  |  ...|..||||.|.|||...| .  ..  . . .  ...   |. .| ||  .|.|.
nssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltes.vvdvfavvkimreqrmmavqtl

SQFEFALDAL
 |. .  .. 
dqyklvhelv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 163-268 2.8e-11 37.4 In-house 181-281 (302) alignment 
Range on Protein: 163-268
Range on HMM: 181-281/302.0
SESVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTaYtlpQSPVLVHCSEGVGRTGTYILIDMTLSrITSGAKEINLAGAVEHLRDQRKQMVKTKS
    .  .|.  ... .|     |... . ||  .  .. |   .  ||||||.||||||| . |   .  . |  |  .|.  |  .|. |   |....
kkkkkvkktvdilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeq

QFEFAL
|  . |
qliyll
0048076 (Phosphotyrosine protein) phosphatases II 164-270 1.5e-18 62.4 In-house 39-138 (145) alignment 
Range on Protein: 164-270
Range on HMM: 39-138/145.0
ESVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPqSPVLVHCSEGVGRTGTYILIDMTLSritsgaKEINLAGAVEHLRDQRKQMVKTKSQ
|   ..|...|..||.|    .|  .  ||.| . ...|.  .  ||||||| |||||||...... |.      . ..|  |.|..| || ..| . .|
elellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpgq

FEFALDA
..| ...
lrflyef
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 165-274 5.2e-29 96.3 In-house 170-279 (318) alignment 
Range on Protein: 165-274
Range on HMM: 170-279/318.0
SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAY-TLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQ
 .. ||.. |.|| ||.    |.... |||. |.|..|  .  ..|..|||| ||||||..| .|. | ||    . ... . |..||.||. ||.|..|
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikae.alvDvfqtvkqlreqrnlmvqtedq

FEFALDALVQE
.||  |.|.. 
yefiydvllea
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 165-273 1.4e-24 81.9 In-house 180-288 (298) alignment 
Range on Protein: 165-273
Range on HMM: 180-288/298.0
SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTaYTLP--QSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKS
... .|.. |.|. ||.  . |.| | .||. |||.. ..    ..||.|.||.||||.||.| ||  | |.    . . .  .|. || .| ..|.|..
keekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqtee

QFEFALDALVQ
|. |  .|  .
qYvfiyeavle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 165-277 2e-23 77.6 In-house 169-281 (439) alignment 
Range on Protein: 165-277
Range on HMM: 169-281/439.0
SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTL-PQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKeINLAGAVEHLRDQRKQMVKTKSQ
. .  ||. ||||..|     ||. . .||| | ...|       ||.|||| ||||||| | .|..| .. .  | ... | |. ||.||||||..  |
ttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenk.vdikgivkvlrkqrkqmvqalcq

FEFALDALVQETQY
. |  .|.... .|
yvfiynavledivy
subfamily_PTPRK_pd Subfamily PTPRK 165-273 8.4e-22 72.4 In-house 168-275 (314) alignment 
Range on Protein: 165-273
Range on HMM: 168-275/314.0
SVQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQF
...  |.. ||..|.|.    | . | ||.. |.||.     . ...|||| | |||||.| ||. |  |    . ...  ||  ||...  ||.|. |.
gqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmier.egvvdvfnavktlrsrkvnmveteeqy

EFALDALVQ
 |  |....
kfiydvile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 165-274 2.3e-18 61.2 In-house 168-277 (287) alignment 
Range on Protein: 165-274
Range on HMM: 168-277/287.0
SVQYSRTITQFHYLSWSVAA-PPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQRKQMVKTKSQ
. .  ....|... .|      .   | || . ...|| .   .....||||..|||..... ...|. .       |..   ... | |. ..|.| .|
kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG.viDvfqvlksqriqkpgsvqtveq

FEFALDALVQE
..|  |.... 
ykfindivley
subfamily_CG7180_pd Subfamily CG7180 165-273 3.4e-18 60.3 In-house 175-288 (296) alignment 
Range on Protein: 165-273
Range on HMM: 175-288/296.0
SVQYSRTITQFHYLSWSV-AAPPANPTPLLDFWRKVKTAYTLP-----QSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMV
 .   |....|..  | .    |   . |... |.|..          ..||.|..|.|..|.| |. ||..|  .    .|... .||  || .|.|.|
vkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLv

KTKSQFEFALDALVQ
 .. .. .  | | .
enveeYkyiYdvlle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 165-274 2.8e-17 57.5 In-house 173-282 (290) alignment 
Range on Protein: 165-274
Range on HMM: 173-282/290.0
SVQYSRTITQFHYLSWSVAA-PPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQ
| ......||..  .|      ... | || . . .|| .   . ...||||..|||..... ...|. .  .    |..   ....| |. ..|.|. |
sagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqq

FEFALDALVQE
...  . ... 
yqgifqivlty
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 165-272 3.8e-11 37.2 In-house 183-290 (301) alignment 
Range on Protein: 165-272
Range on HMM: 183-290/301.0
SVQYSRTITQFHYLSWSVAAP-PANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQ
| . |....|..  .|      .   | |      ...      .||.||||..|.|.|.|. ....|    .    ... . .. .| ..  .|.|  |
sdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckae.gVVdvfqvtkavrrskpgaVtTLeq

FEFALDALV
. .  |.. 
ytsiydvid
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 166-276 6.2e-26 86.2 In-house 174-284 (305) alignment 
Range on Protein: 166-276
Range on HMM: 174-284/305.0
VQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQS-PVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQF
 . |||..|..  .|     |  .| ||.. ..|. ..   .  |.|||||.||||||..| .|. | |.    ....... . .|| .| .||.|. |.
dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqY

EFALDALVQETQ
 |  ||| ....
vflhdaldelit
subfamily_PTPRG_pd Subfamily PTPRG 166-273 1e-22 75.1 In-house 179-285 (563) alignment 
Range on Protein: 166-273
Range on HMM: 179-285/563.0
VQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFE
 .. ....|.|| .|   . |  ..| | | .| ..|      |..||||.||||||||| .|  | .| .  . .|. | . |.| ||  .|.|. |. 
cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYi

FALDALVQ
|  |||..
flhdalle
subfamily_PTPN1_pd Subfamily PTPN1 166-280 6.1e-22 72.7 In-house 158-276 (290) alignment 
Range on Protein: 166-280
Range on HMM: 158-276/290.0
VQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQ--SPVLVHCSEGVGRTGTYILIDMTLSRITSGAK--EINLAGAVEHLRDQRKQMVKTK
 | .|.|..|||..|.  . |  |. .|.|  ||. . .| .   |...||| |.||.||..|.|  | .|    .   ...   . .|| .|  ...|.
tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

SQFEFALDALVQETQYMLN
 |..|.  |... .. . .
dqlrfsylaileGakvikg
0048179 (Phosphotyrosine protein) phosphatases II 166-267 6.9e-18 60.2 In-house 43-137 (144) alignment 
Range on Protein: 166-267
Range on HMM: 43-137/144.0
VQYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTlPQSPVLVHCSEGVGRTGTYILIDMTLsritsgAKEINLAGAVEHLRDQRKQMVKTKSQFE
  . |...|...|.|    .|  .. ||.| . ...|.  .  ||||||| |||||||...... .       . ..|  |....| .| ..| . .|..
efleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnpgqlr

FA
| 
fL
subfamily_PTPRN_pd Subfamily PTPRN 167-279 2.5e-44 146.2 In-house 184-296 (297) alignment 
Range on Protein: 167-279
Range on HMM: 184-296/297.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEF
. .||.||||.|||   . ||.. .||.| |||  .|    .|..||||.|.||||.|||||. |.|.. |.|||..| ..|||||||...||||.||||
setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef

ALDALVQETQYML
|| |...| . .|
altavaeevnail
subfamily_PTPRD_pd Subfamily PTPRD 167-273 6.1e-34 112.6 In-house 174-279 (564) alignment 
Range on Protein: 167-273
Range on HMM: 174-279/564.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEF
. ||...|||. ||     | ..|.|||..|||... .  . |..|||| |||||||.| ||. | ||..  | ... . |..|| ||. ||.|..|. |
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiF

ALDALVQ
  .|...
iheaile
DSPc_SM00195 167-274 3e-28 94.3 In-house 155-261 (263) alignment 
Range on Protein: 167-274
Range on HMM: 155-261/263.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKeINLAGAVEHLRDQRKQMVKTKSQFEF
. .|..||..| .|     | .....|.. |.||. .   ..|..|||| |||||||...||. ||..... | ...   |..||.|| .||.|. |. |
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlf

ALDALVQE
. .|... 
iyeailey
PTPc_SM00194 167-274 3e-28 94.3 In-house 155-261 (263) alignment 
Range on Protein: 167-274
Range on HMM: 155-261/263.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKeINLAGAVEHLRDQRKQMVKTKSQFEF
. .|..||..| .|     | .....|.. |.||. .   ..|..|||| |||||||...||. ||..... | ...   |..||.|| .||.|. |. |
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlf

ALDALVQE
. .|... 
iyeailey
subfamily_PTPRB_pd Subfamily PTPRB 167-273 8.3e-28 92.3 In-house 176-283 (293) alignment 
Range on Protein: 167-273
Range on HMM: 176-283/293.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAY--TLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQF
. .|...|.|..||.    | ....||||.|.|..|   |  ..|..|||| |||||||.| .|. |..|..    ....| | .|| .|...|.|..|.
keerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqY

EFALDALVQ
 |  .....
ifihqcvld
subfamily_PTPN6_pd Subfamily PTPN6 167-273 1.5e-26 88.1 In-house 183-295 (306) alignment 
Range on Protein: 167-273
Range on HMM: 183-295/306.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLP----QSPVLVHCSEGVGRTGTYILIDMTLSRITSGA--KEINLAGAVEHLRDQRKQMVKT
. .|.. |.|. ||  .. |..|  .|||...|.. .       . |..||||.|.|||||.|.||. |. |..     .|..  .|. .|.||...|.|
keerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqt

KSQFEFALDALVQ
..|. |   |. .
eqqykfvykaikk
subfamily_PTPRA_pd Subfamily PTPRA 167-273 2.1e-26 87.6 In-house 188-293 (330) alignment 
Range on Protein: 167-273
Range on HMM: 188-293/330.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEF
. || ..|||. ||     |..|  .|.. .|||.      .|. |||| |||||||.| .|  | |. .  . ... ..|..|| || |||.|. |.||
kksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervka.erkvdvfefvkrlrlqrpqmvqtdeqyef

ALDALVQ
   .| .
iykvlle
subfamily_PTPN3_pd Subfamily PTPN3 167-274 8.3e-26 85.5 In-house 168-274 (280) alignment 
Range on Protein: 167-274
Range on HMM: 168-274/280.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSrITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEF
. .|.|.|. ||.|.  . | ... .|.| ..|... .  ..||.|||| |.|||| .||....|. ..  |....    | ..||||. .|.|.||..|
keerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykf

ALDALVQE
  .|... 
vCeailkv
subfamily_PTPN12_pd Subfamily PTPN12 167-281 1.2e-25 85.0 In-house 167-283 (290) alignment 
Range on Protein: 167-281
Range on HMM: 167-283/290.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAK--EINLAGAVEHLRDQRKQMVKTKSQF
. ||...|||| .|     |.....||.. ..|..  .  ..|..|||| ||||||| | ||.. . . ..    |...   | .|| ||. .|.|| |.
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

EFALDALVQETQYMLNA
|.   |...  |  |..
elvykavaelvqkelei
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 167-275 4.2e-23 76.8 In-house 134-242 (250) alignment 
Range on Protein: 167-275
Range on HMM: 134-242/250.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTL-PQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFE
. .|.. |.|...|   . |.. |  |.. .||..      ..||.|.||.||||.|..| ||  | |.    | ...   .. || .| ..|....|. 
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk.ekvvdvfkvikvlrkdrphavesleqyv

FALDALVQET
|   .. . .
fvyeiilkal
subfamily_PTPN13_pd Subfamily PTPN13 167-273 1.2e-21 72.2 In-house 163-267 (273) alignment 
Range on Protein: 167-273
Range on HMM: 163-267/273.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTlPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEF
. || ...... .|     |.....|| | ..|..  |  ..|..|||| |.||.||.| ||. |  |    ||...   |..||.||. .|.|| |. |
gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglier.dkefdvkeivrklreqrqgvvqtkdqyif

ALDALVQ
   |...
vykaile
subfamily_PTPN23_pd Subfamily PTPN23 167-280 5.2e-21 69.7 In-house 168-285 (288) alignment 
Range on Protein: 167-280
Range on HMM: 168-285/288.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLP----QSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKS
.  ....  .. ||.    || |  ||.|  .|..||.      . |..|||| ||||||.. |.   .  .. |   ...   |..|| ||. ||..|.
davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

QFEFALDALVQETQYMLN
|..|...| ..... .|.
qlkfsyeavleaarrvld
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 167-274 1.6e-20 68.2 In-house 170-276 (315) alignment 
Range on Protein: 167-274
Range on HMM: 170-276/315.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEF
. |||.|||..  |     . . . || . ..||.     . ..||||| ||||||  | ||  ...|  . . ...   |. ||..| ..|.|. .. |
eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrt.rsvdvfnfvknlrakrpylvqteeeyaf

ALDALVQE
  ||. ..
iydavled
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 167-274 2.1e-18 61.4 In-house 158-267 (274) alignment 
Range on Protein: 167-274
Range on HMM: 158-267/274.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAY---TLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQ
. .|... . | .|     | ....|||. ..|...    . . .||.|||| |.|||| .| |.... ..    . ... . | .|| .|  ||.|..|
erersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.eivvdvlkivcnlrldrGGmvqtseq

FEFALDALVQE
.|.   ||.. 
yelihralcly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 167-269 3e-13 44.5 In-house 130-233 (237) alignment 
Range on Protein: 167-269
Range on HMM: 130-233/237.0
QYSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTA--YTLPQSPVLVHCSEGVGRTGTYILIDMTLsRITSGAKEINLAGAVEHLRDQRKQMVKTKSQF
.  | | |... ||     | . . || | ...     .    .| ..||| |||||| ...||  | | .   | ...   |  . ..|  ...|| |.
kevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.rqakekkvvdiynyvysieedrpyiiqtkdqy

EFALD
 |  .
vfihq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 167-267 6.8e-13 43.3 In-house 173-269 (307) alignment 
Range on Protein: 167-267
Range on HMM: 173-269/307.0
QYSRTITQFHYLSWSVA-APPANPTPlLDFWrkvkTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFE
| ||||... .  |    .|. | |  ...      |    . ||.|||| ||||.|| . | .   .. .|    ..   || ||.||.  ..|. |. 
qksrtiqhlqwenwpdrgvpqinlta.inll....eavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl

FA
. 
yl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 167-269 1.6e-06 22.0 In-house 168-273 (303) alignment 
Range on Protein: 167-269
Range on HMM: 168-273/303.0
QYSRTITQFHYLSWSVAAPPAN--PTPLLDFWR--KVKTAYTLPQSPVLVHCSeGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKS
.|   .   || .|  .. |..  |  . . |.   |   |.  . .| .  | |.||.||. |.. .   . |    ..|   .| .|. | . |.  |
dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnls

QFEFALD
|| .   
qfsvvyt
Y_phosphatase Protein-tyrosine phosphatase 168-272 4e-29 97.1 Pfam-A 131-234 (235) alignment 
Range on Protein: 168-272
Range on HMM: 131-234/235.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKeINLAGAVEHLRDQRKQMVKTKSQFEFA
 .|...|.|| .|     |..|..|||. |||..  .  ..||.||||.|||||||....|. |...... . ...  .|..|| || .||.. .|..| 
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYifl

LDALV
 .|..
ykail
Y_phosphatase Protein-tyrosine phosphatase 168-272 4e-29 97.1 In-house 131-234 (235) alignment 
Range on Protein: 168-272
Range on HMM: 131-234/235.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKeINLAGAVEHLRDQRKQMVKTKSQFEFA
 .|...|.|| .|     |..|..|||. |||..  .  ..||.||||.|||||||....|. |...... . ...  .|..|| || .||.. .|..| 
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYifl

LDALV
 .|..
ykail
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 168-274 3.8e-25 83.5 In-house 168-275 (281) alignment 
Range on Protein: 168-274
Range on HMM: 168-275/281.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQ-SPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEF
 .|...|..|..|     ||... ||.| ..|. . .  .  |...||| ||||||||| .|  ...... ..|...   |..|| .|. ||.|  |.||
etreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyef

ALDALVQE
   |... 
vykavlda
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 168-272 9.3e-23 75.8 In-house 175-281 (297) alignment 
Range on Protein: 168-272
Range on HMM: 175-281/297.0
YSRTITQFHYLSWSVAAPPA--NPTPLLDFWRKVKTAYTLPQS-PVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQF
  | . |.....| . | .   . . ||..   |.  .   .. |.||||. |||||| .. ||  ....    ||... | |..||..| ..|.|| |.
arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqy

EFALDALV
.|   |..
kfvyvavl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 168-276 3.4e-22 74.2 In-house 183-292 (319) alignment 
Range on Protein: 168-276
Range on HMM: 183-292/319.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAY--TLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFE
  | |||||.| |     |  |..|. . .||.        . ...|||| ||||||.|| .|. |.|.    | ...   |. ||.||...|.   |. 
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqyk

FALDALVQETQ
|   ||..|  
fiysalleehl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 168-277 6.8e-22 73.3 In-house 147-257 (284) alignment 
Range on Protein: 168-277
Range on HMM: 147-257/284.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAY--TLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFE
  |.|.|||.| |     |  |..|. . .||.        .....|||| ||||||.|| .|. |.|.    | ...   |. ||.||...|.   |. 
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqyk

FALDALVQETQY
|   ||..|  .
fiysalleehlf
subfamily_PTPN14_pd Subfamily PTPN14 168-273 5.4e-19 63.3 In-house 181-294 (300) alignment 
Range on Protein: 168-273
Range on HMM: 181-294/300.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKT-----AYTL----PQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMV
  ||.  . |  |.    | .... |.. ..|.        .      . |||||||.||||||  || |. .. .  . .||..  ....|| ||  .|
eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllv

KTKSQFEFALDALVQ
.| .|..|  ..|..
qtlaqYkfvYkvlik
subfamily_PTPN9_pd Subfamily PTPN9 168-275 9.5e-18 59.2 In-house 171-290 (297) alignment 
Range on Protein: 168-275
Range on HMM: 171-290/297.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTA-------------YTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQR
 ||..| | .|||     | . . |||. .||. .             . . . |..|||| |.|||||.| .|..|||. . .  ...  .|..|| ||
esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg.tvdvvetvkllrtqr

KQMVKTKSQFEFALDALVQET
  ...|  |.||   |... .
afsiqtpeqyefcylavleya
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 168-273 1.2e-14 48.5 In-house 87-192 (440) alignment 
Range on Protein: 168-273
Range on HMM: 87-192/440.0
YSRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAY-TLPQSPVLVHCSEGVGRTGTYILIDMTLsRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEF
 |||. |.|| .|   . |    |.| . . |. .     ..|.||||| |.||||  | .|  | | .  . .|..   .. .|..| |||.|  |. |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsil.reakrsdqidifsfinsmrnnrpqmvqtpeqyaf

ALDALVQ
  .|...
vheavle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 169-274 1.1e-29 98.5 In-house 177-282 (319) alignment 
Range on Protein: 169-274
Range on HMM: 177-282/319.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLP-QSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQRKQMVKTKSQFEFA
.|....|.|..|.  . | . | |||...... .   . . |. ||||.|||||||.| .|..| |.   .  ...   | .|| ||. ||....|..| 
tRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfi

LDALVQE
 .||.. 
yeallea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 169-272 1.5e-28 94.7 In-house 174-276 (288) alignment 
Range on Protein: 169-272
Range on HMM: 174-276/288.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
 ..|||..||.|.    |.. .|||.. |.||.| .  . |..||||.|||||||.| .|. . .. .  . |..||.|..|| ||...|.|..|.||  
eleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiy

DALV
..|.
evll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 169-274 1e-20 68.4 In-house 171-275 (515) alignment 
Range on Protein: 169-274
Range on HMM: 171-275/515.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
|||.||||.  |     | . . || . ..||.     . |...||| |||||| .| ||  ....  . . ...   |. .|..| ..|.|. |. |  
srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirqkrpylvqtqeqyafiy

DALVQE
.|. ..
gavled
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 169-277 1.1e-18 62.3 In-house 151-266 (270) alignment 
Range on Protein: 169-277
Range on HMM: 151-266/270.0
SRTITQFHYLSWSVAAPPAN------PTPLLDFWRKVKTAYTLP-Q-SPVLVHCSEGVGRTGTYILIDMTLSRItSGAKEINLAGAVEHLRDQRKQMVKT
.| .. |.| .|   . | .      .. ||   |.|.   .   . .|.|||||.||||||| |..|...  . .  |.....  .|.|| .| ..|..
errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlL.eetkkvdvlaiieelRkdRmalvqh

KSQFEFALDALVQETQY
  |.||.  |.|. ...
peqyeflykavveyaer
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 169-274 1.2e-17 59.1 In-house 177-287 (325) alignment 
Range on Protein: 169-274
Range on HMM: 177-287/325.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKT------AYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAkEINLAGAVEHLRDQRKQMVKTKS
.|.. ||.. ||     .  |. |. . . ||.      | |   .|.|||||.||||||..| .   | ..   . .... | |..|| .| .||.|  
trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviees.rvdifgfvkklrkdrpsmvetvd

QFEFALDALVQE
|. .  .|||. 
qyiliyealvea
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 169-268 2.2e-14 48.2 In-house 135-233 (239) alignment 
Range on Protein: 169-268
Range on HMM: 135-233/239.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLsRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
 | . |.|.  |     |   | .| . ||.         | ..||| ||||||....||  | | .   | ...   |. .|..| .||.|  |. |  
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.rqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 169-268 2.5e-14 48.0 In-house 136-234 (239) alignment 
Range on Protein: 169-268
Range on HMM: 136-234/239.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLsRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
 | . |.|.  |     |   | .| . ||.         | ..||| ||||||....||  | | .   | ...   |. .|..| .||.|  |. |  
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.rqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 169-264 2e-13 44.8 In-house 180-270 (301) alignment 
Range on Protein: 169-264
Range on HMM: 180-270/301.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAytlpQSPVLVHCSEGVGRTGTYILIDMtLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQF
.||.| . | .|.    |   . | |.   || .    . |..||||.|.||. ..|  .. |.|     ..|.|. |..|||..| . |.|.||.
trtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigtey.lareveadptieltealkhlrehrwngvqtnsql
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 169-273 2.1e-13 44.7 In-house 167-275 (287) alignment 
Range on Protein: 169-273
Range on HMM: 167-275/287.0
SRTITQFHYLSWsvAAPPANPT--PLLDFWRKVKTAYTLP-----QSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTK
.| . |...|||   .  . ||   |. |  .||    |        |..||.. |.||.|... . . .||  .   ... | .| .|| .|. .|.. 
arvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrled.lGrvdvaavvirlreyraalvqav

SQFEFALDALVQ
 |. .  .||| 
vqlrllyealvt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 169-269 3e-12 41.2 In-house 170-265 (288) alignment 
Range on Protein: 169-269
Range on HMM: 170-265/288.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAytlpQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
.  . . |.| |   . | |  . | .   .|.     | |..||.|.||||||| ||| . |  . .    . .   ...||..|.. ..|. |. .. 
kvivkilhlleWdddgvPenylsplrllevlksl....qkPivvhssaGvGrtgtlililialeslrl.ddflgirsllaklreerfkaiqtemqylyvh

D
 
r
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 169-271 4.9e-12 40.2 In-house 185-283 (305) alignment 
Range on Protein: 169-271
Range on HMM: 185-283/305.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAytlpQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
.| .|..|.  |     ||  . .|..  | ...    . |. |||| |.||||. ....  | .. .| .  .    . ..|.||.. ..|  |. |  
arkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

DAL
. .
qvi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 169-270 1e-09 32.8 In-house 115-216 (255) alignment 
Range on Protein: 169-270
Range on HMM: 115-216/255.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAytlpqSPVLVHCSEGVGRTGTYILIDMTLS-----RITSGAKEINLAGAVEHLRDQRKQMVKTKSQ
 .|.. ..|  |     | ..  .|  .. |. .      .|.||||.|.||. ...|...          |. . |..    .|.|| .||. ..|  |
thtvkhysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

FEFALDA
. |..  
lafsilm
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 169-267 1.6e-08 28.5 In-house 166-261 (281) alignment 
Range on Protein: 169-267
Range on HMM: 166-261/281.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTlpqsPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRD-QRKQMVKTKSQFEFA
.| ||.. .  |     |     .|   ||...  |    | ..||| ||||.|| . ....|  | |     ..   | |||   |   |.|  |. . 
trlithwlwkewpdwqvpessevmlkilrkirarst....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymli
subfamily_hpo-7_pd Subfamily hpo-7 169-271 3.3e-07 24.5 In-house 121-223 (263) alignment 
Range on Protein: 169-271
Range on HMM: 121-223/263.0
SRTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAytlpqSPVLVHCSEGVGRTGTYILIDMTLS-----RITSGAKEINLAGAVEHLRDQRKQMVKTKSQ
 .|.... |  |     | ..   |   . ..        .. ||||.|.||.  . ....          |. . |..    .|.|| .||. ..|  |
thtvkhysykgWiekndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq

FEFALDAL
. |..  .
Lafsilmv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 169-266 5.2e-06 20.8 In-house 93-194 (198) alignment 
Range on Protein: 169-266
Range on HMM: 93-194/198.0
SRTITQFHYLSWSVAAPPaNPTPLLD---FWRKVKTAYTL-PQSPVLVHCSEGVGRTGTYILIDMTL-SRITSGAKEINLAGAVEHLRDQRKQMVKTKSQ
.| |... . ||   . | | . ..      |.|   |    ..||.||||.| | || .. .|. . |   | .  ..|      ||. |  .. .  .
treishyqftswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh

FEF
..|
ynf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 170-273 2.1e-22 74.4 In-house 175-277 (315) alignment 
Range on Protein: 170-273
Range on HMM: 175-277/315.0
RTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEFALD
|.. |.|| ||  .  |.  .||... |.||   |   ....||||.|||||||.| .|  | ..    . |..  ... .|..|..||..  |..|  |
revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiyd

ALVQ
||..
alle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 170-280 6.6e-14 46.6 In-house 156-264 (267) alignment 
Range on Protein: 170-280
Range on HMM: 156-264/267.0
RTITQFHYLSWSVAAppaNPTPLLD--FWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFA
. .| ..|  | . .   |  | |   |    |      . |..|.||.||||.||.. ||  | |.       ..   . ..|.||  .|.|| .. . 
hnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakte.gvsdifdflrkirsqriglvdtkeryiyi

LDALVQETQYMLN
 . |.. ....|.
hellaeyaegrlk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 170-276 1.7e-11 38.8 In-house 158-260 (290) alignment 
Range on Protein: 170-276
Range on HMM: 158-260/290.0
RTITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTlpqsPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFALD
 |.|   . .|.    . ..  ||.  .|||.  |    ||.||| .|. |  .   |..    |    ....|. ... || || ... .. .. |.. 
ftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

ALVQETQ
..|   .
givllai
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 170-266 5.4e-06 20.7 In-house 95-195 (199) alignment 
Range on Protein: 170-266
Range on HMM: 95-195/199.0
RTITQFHYLSWSVAAPPaNPTPLLD---FWRKVKTAYTL-PQSPVLVHCSEGVGRTGTYILIDMTL-SRITSGAKEINLAGAVEHLRDQRKQMVKTKSQF
| |... . ||   . | | . ..      |.|   |    ..||.||||.| | || .. .|. . |   | .  ..|      ||. |  .. .  ..
reishyqftswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

EF
.|
nf
PTPc_DSPc_SM00012 171-272 5.3e-28 92.7 In-house 1-104 (105) alignment 
Range on Protein: 171-272
Range on HMM: 1-104/105.0
TITQFHYLSWSVAAPPANPTPLLDFWRKVKTAYTLPQ--SPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFAL
|....||..|.    | .....|.. |.||. ..  .  .||.|||| |||||||....|. |...... ||...   |..||.|| .||.|. |. | .
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DALV
.|| 
rall
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 172-273 1.1e-12 42.2 In-house 185-281 (290) alignment 
Range on Protein: 172-273
Range on HMM: 185-281/290.0
ITQFHYLSWSVAAPPANPTPLLDFWRKVKTAytlpQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFALDAL
.  ..  ||   . .     ||   | ...|      || |||| |.|||||.. |...|  .. | ||..|.. |  ||. | . |.   |.   ...|
lkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldG.keldlldlvralrnsrlnsvqvdiqylalveil

VQ
..
ld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 180-271 3.3e-11 37.7 In-house 177-266 (285) alignment 
Range on Protein: 180-271
Range on HMM: 177-266/285.0
WSVAAPPANPTPLLDFWRKVKTAYTlPQSPVLVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEFALDAL
|     | .  |...... ||      . |. |||| ||||| |.. || .  ||     .|..   |  .|  | | |... || |    |
wpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidyatirime.npniemldivremramrfqavqshmqflflyvvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 185-267 3.8e-07 23.8 In-house 196-277 (302) alignment 
Range on Protein: 185-267
Range on HMM: 196-277/302.0
PPANPTPLLDFWRKVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGaKEINLAGAVEHLRDQRKQMVKTKSQFEFA
 | . . |     || .  .  ......   .|.|| |. .   ........| || | .  |. .| || ..| . .|. . 
vpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvsl
0038934 (Phosphotyrosine protein) phosphatases II 188-266 1e-07 27.3 In-house 95-168 (194) alignment 
Range on Protein: 188-266
Range on HMM: 95-168/194.0
NPTPLLDFWRKVKTAYT-LPQSPVLVHCSEGVGRTGTYILIDMTLSritsgaKEINLAGAVEHLRDQRKQMVKTKSQFEF
.   ||.| . |.. .   |.  |.|||  |.||||| .   .  .        ...  |....|. |. .. . ...| 
sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr......lgmsaeeAialfrekRpgaipnqdylea
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 198-272 1.9e-09 31.7 In-house 200-273 (312) alignment 
Range on Protein: 198-272
Range on HMM: 200-273/312.0
KVKTAYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEiNLAGAVEHLRDQRKQMVKTKSQFEFALDALV
.. .|    . ||. ||| ||||||| .||.  .. .    |. |.  .   || .| . |..  |. .|| ...
rllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkq.nvkdsfvllrkdrarsvrvfpqyvyalrcvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 202-269 1.1e-10 35.6 In-house 216-283 (305) alignment 
Range on Protein: 202-269
Range on HMM: 216-283/305.0
AYTLPQSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFALD
|    . |..|||| |.||||| . |.  | .|.   .   .   |  |||||   ...  |. |   
airgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihr
subfamily_CG42327_pd Subfamily CG42327 207-270 4.1e-14 47.0 In-house 247-310 (319) alignment 
Range on Protein: 207-270
Range on HMM: 247-310/319.0
QSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFALDA
| |. ||||.||||||. |  |... ..    . ...   | ..| .| . |.|| |.||    
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 207-273 7.7e-12 39.7 In-house 228-293 (297) alignment 
Range on Protein: 207-273
Range on HMM: 228-293/297.0
QSPVLVHCSEGVGRTGTYILIDMTLSrITSGAKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQ
. ..||||| ||||.|  .| |. |. ..   .  . |  ...||.|| ..|.|  |||.  || ..
nayllvhcsaGvGrsGvvvlsdvila.klrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 207-272 1.2e-11 39.0 In-house 262-341 (350) alignment 
Range on Protein: 207-272
Range on HMM: 262-341/350.0
QSPVLVHCSEGVGRTGTYILIDMTLS------RITSGAKEINLA--------GAVEHLRDQRKQMVKTKSQFEFALDALV
.||.||||| |||||||.. .|. ||       .|   .... |          | .|| || .||... || |  .|| 
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 207-272 9.8e-09 29.0 In-house 265-341 (349) alignment 
Range on Protein: 207-272
Range on HMM: 265-341/349.0
QSPVLVHCSEGVGRTGTYILIDMTLSRITSGAKEIN---L--------AGAVEHLRDQRKQMVKTKSQFEFALDALV
 |..||||| | ||||... .|. || ..   .| |   |          .| .|| || .||.  .|| . ..||.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 211-273 3.5e-11 37.3 In-house 2-63 (69) alignment 
Range on Protein: 211-273
Range on HMM: 2-63/69.0
LVHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQ
.|||| | |||||.| | . ..|| |  | ...   | ..|  |  ||  . .. |  ||||.
vvhcssgtgrtgtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 212-273 5.6e-11 36.6 In-house 2-62 (69) alignment 
Range on Protein: 212-273
Range on HMM: 2-62/69.0
VHCSEGVGRTGTYILIDMTLSRITSgAKEINLAGAVEHLRDQRKQMVKTKSQFEFALDALVQ
|||| | |||||.| | . ..|| |  | ...   |...|  |  ||  . .. |  ||||.
vhcssGtGrtGtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneneymfihdalve