Gene C07E3.4 in Caenorhabditis elegans

Synonym: CELE_C07E3.4, C07E3.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP013_AA protein Get Run
CeleP013_AA_195-495 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 184-497 1.3e-48 161.3 In-house 15-302 (308) alignment 
Range on Protein: 184-497
Range on HMM: 15-302/308.0
KKHSKQKTKMWLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKT--TEDFEANKVRNREGCPKIYDENRVQLnrpgHEDVNYINASVITlkdvsrrmac
.. | ......| . . |....| .|.....|||  | |. .. .  .  ...|| .||     .|| .|| |    .|. .||||| ..          
rdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvd..........

vpayvhlvvlyfvI--FQFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVPDDKLK-NTTTSLFNDENG-GYQYTGKMFINNRRADVSGDPKEY
             .  . ...| |..| |    .. ||||| |.........  .   .  . ..    . .| | |... ||....... .| .| . .
.............gyssklprkfIatqgPl...pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvr

TIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGV
|.|. . |...| .... |.  |.. . ||.. ........  .    ..  ..| .  |.||.. || ......||. . .....|..| ...|||| |
tleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmv

ESFAQCASIYAIVFDYIARK
... |   .| ....|. .|
qtpeqylflyralleylklk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 186-531 4.3e-250 821.9 In-house 1-346 (346) alignment 
Range on Protein: 186-531
Range on HMM: 1-346/346.0
HSKQKTKMWLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQLNRPGHEDVNYINASVITLKDVSRRMACVPAY
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hskqktkmwlgmpsalnfcnknndiqkireefgfldslvcnkttedfeankvrnregcpkiydenrvqlnrpghedvnyinasvitlkdvsrrmacvpay

VHLVVLYFVIFQFEHKLIVAQLPQMENESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEG
|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpeg

NSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCAS
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
nsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyas

IYAIVFDYIARKRGGKKAPVNKDINRFIDELAEISPACSPTKGMPL
||||||||||||||||||||||||||||||||||||||||||.|||
iyaivfdyiarkrggkkapvnkdinrfidelaeispacsptkvmpl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 187-280 5.3e-06 20.1 In-house 3-93 (302) alignment 
Range on Protein: 187-280
Range on HMM: 3-93/302.0
SKQKTKMWLGMPSALNFCNKnNDIQKIREEFGFLDSL-VCNKTTEDFEANKVRNREGCPKIYDENRVQLNrpgHEDVNYINASVITLKDVSRRMA
 ..... | .   |... ..  | .....||  .|.. |     . | .|  .|.    .|.|.|.|.|.   .|  .|.||| ... ...| . 
veeekekWveeeeakklvks.ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsii
0039614 (Phosphotyrosine protein) phosphatases II 188-498 2.3e-49 163.8 In-house 9-293 (297) alignment 
Range on Protein: 188-498
Range on HMM: 9-293/297.0
KQKTKMWLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQLNRPGH--EDVNYINASVITLKDVsrrmacvpay
..   ..|..  .|....| |.......||  | ||......  ...|| .||     .|| .||.|. ...  .| .||||| ..  |.          
lesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl..........

vhlvvlyfvifqFEHKLIVAQLPqmeNESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGgyqYTGKMFINNRRADVSGDPKEYTIEVLPeg
            . .| |..| |   ... ||||| |....... .  . . . |...  . . .| |   . |........ .. .. . .|.|| .  
............ltrkfIatqgP...lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..

NSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQC
|. | ....... .| . . || .  .......  .  .   ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|... | 
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

ASIYAIVFDYIARKR
  .| ...... ||.
rflydallellkrkl
0040438 (Phosphotyrosine protein) phosphatases II 194-529 5e-53 175.8 In-house 2-309 (317) alignment 
Range on Protein: 194-529
Range on HMM: 2-309/317.0
WLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITlkdvsrrmacvpayvhlvvly
.|... ||....|..  .  .| . .|.  ... ..  ...|| .||     .|| .||.|.  .|..| .||||| ..                     
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvd.....................

fvIFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIC
  .... .| |..| |.   .. ||||| |.........  ... . |.. .   .  . |.... |.......  .. .. . .|.|| . |.|.|...
..gpnlkrkfIatqgPl...pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtv

QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFD
...|.  | .   || . ........  .  . ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|....|   .| ....
thfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle

YIarKRGGKKAPVNKDINRFIDELAEISPACSPTKGM
|.  ||.... |... ..... .|... .  .. | .
yl..krkltlepaselklkllklliplalddvklkek
0043336 (Phosphotyrosine protein) phosphatases II 194-494 1.7e-47 157.6 In-house 4-277 (278) alignment 
Range on Protein: 194-494
Range on HMM: 4-277/278.0
WLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITlkdvsrrmacvpayvhlvvly
. ... ||. ...|.    ..| . .|.  ......  ...|| .||     .|| .||.|.  .|..| .||||| ..                     
vkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvd.....................

fvIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIC
   ... .| |..| |   ... ||||| |....... .  ..... |....   .    ||... |........ .. .| . .|.|| . |.. | ..
..gynvprkfiatqgP...lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtv

QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFD
...|. .| . . |. . ...........  . .|  |.| .  |.||.. ||.......||... .....|..| ...|||| |... |   .| ....
thyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

YI
|.
yl
subfamily_Ptp69D_pd Subfamily Ptp69D 197-495 8.1e-21 69.4 In-house 9-287 (307) alignment 
Range on Protein: 197-495
Range on HMM: 9-287/307.0
MPSALNFCNKNNDIQKIReEFGFLDSLVCNKTTE--DFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITlkdvsrrmacvpAyvhlvvlyf
...||.  ... |  ... |.  | .  ..|.|.  . . |...||    | .|..||.|.. .|.|| .||||| |             .         
leealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik............g.........

viFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVyLMVPDDKLKNT--TTSLFNDEnGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG------
  .. ..| |.|| |    |. ..||| || . ...|.  |. . . ||       . .|    ||  .. ..  . .  .|  . ...|   .      
..ykekkkfiaaqdPv...eatigDfWRmiaeqevtli.vmlsnlteknrkkcakYWpie.devqyg.dilvklvseekhsdyiiReldvskkkeesgev

NSDSVICQvHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCAS
.    . | .|.  ||  . |  .  ..|.|.|  . .. ... . |    | ||.  |.     ..||..  . .|.|..|....||.  |.|..|   
edsrkvvq.yhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvf

IYAIVFDYIA
.|  . ||. 
lyralldyss
0036941 (Phosphotyrosine protein) phosphatases II 201-498 1e-50 168.1 In-house 3-281 (297) alignment 
Range on Protein: 201-498
Range on HMM: 3-281/297.0
LNFCNKNNDIQKIREEFGFLDSLV--CNKTTEDFEANKVRNREGCPKIYDENRVQLnrpGHEDVNYINASVITlkdvsrrmacvpayvhlvvlyfvIFQF
|.. .| ........||  |..|   .....  ...|. .||     .|| .||.|   ..|. .||||| ..                       ....
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvd.......................gydl

EHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADV--SGDPKEYTIEVLPEGNSDSVICQVH
..| |..| |.   .. ||||| |....... .  ..... | ...  . . .|.|.... |........ .|  ..| . .|.||.. ||..| .....
krkfIatqgPl...pntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthf

HHAPWKHLQQPPKTLPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLN---NGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIV
|.  | .   |. . .....|.....  .   ..  |.| .  |.||...||.| ....||.      ...|.|..| ...|||| |... |   .| ..
hytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal

FDYIARKR
.... .|.
lellkkkl
0047943 (Phosphotyrosine protein) phosphatases II 202-494 4.3e-46 152.9 In-house 3-272 (273) alignment 
Range on Protein: 202-494
Range on HMM: 3-272/273.0
NFCNKNNDIQKIREEFGFLDSLV--CNKTTEDFEANKVRNREGCPKIYDENRVQLnrpGHEDVNYINASVITLKdvsrrmacvpayvhlvvlyfvifQFE
....| .......|||  | ||   .....  ...|| .||     .|| .|| |   |... .||||| ...                        ...
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgy.......................nlk

HKLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMVPDDKL-KNTTTSLFNDENGG-YQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHH
.| |..| |  ..   ||||| |.........  ..... | ...    . .|.|. ... ||....... .. .| . .|.|. . |...| .....|.
rkfiatqgPlpnt...vedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhy

APWKHLQQPPKTLPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
 .|   . || . .....|..  .  .   .|  |.| .  |.||...|| ......||. . .....|..| ...||||.|... |   .| ....|.
tgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 203-496 5.1e-45 149.9 In-house 19-306 (307) alignment 
Range on Protein: 203-496
Range on HMM: 19-306/307.0
FCNKNNDIQKIREEFGFLDSLVC----NKTTEDFEANKVRNREGCPKIYDENRVQLNRPGH--EDVNYINASVITLKDVSrrmacvpayvhlvvlYFVIF
. .. ........||  | |. .    . ..  ...|| .||     .|| .||.|. ...  || .||||| ... ..                .. ..
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplll...............lldgy

QFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GNSDSVICQVH
 . .| |..| |.   .. ||||| |.........  . ... |..     .  ..|.... |........ .. .. . .|.|| .  |.. | .....
dlkrkfIatqgPl...petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

HHAPWKHLQQPPKTLPIIKMIHQFLS--EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIE---PNICEIMKNIKQQRPGGVESFAQCASIYAIV
|.  | . . || . .....|.. ..  |.  ..  |.| .  |.||...||.|.... ||... .   ... |..| ...||||.|... |   .| ..
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

FDYIAR
.... .
lelllk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 203-495 3.9e-14 46.6 In-house 10-277 (515) alignment 
Range on Protein: 203-495
Range on HMM: 10-277/515.0
FCNKNNDIQKIREEFGFLD-SLVCNKTTEDFEANKVRNREGCPKIYDENRVQLN-RPGHEDVNYINASVITlkdvsrRMACVPAYvhlvvlyfvifqfeh
| |||.    . |||  |    .  .|  . | |  .|| .    || .||.|.      . .|.||| |        . .  ||               
fvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip......sfdndkay...............

klIVAqlpQMENESFVEDFWYMIYQEQINLVYlMVPDDKLKNT--TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNsDSVICQVHHHa
  | .   |. |.. |.||| ...||..  .  || . |  .    .  . |  |     |.. ..    .  ..    ...|| . .    . | | . 
..ias...qgPnkasvddfWrlvlqenvttia.mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhft.

PWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
 | .   |..|  ..|.|..  ....  .  . .  . | ||.  .| .   . . ...   .. ....||.|.||  |    | | || .| ... 
eWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 206-270 3.8e-06 21.0 In-house 15-84 (290) alignment 
Range on Protein: 206-270
Range on HMM: 15-84/290.0
KNNDIQKIREEFGFLDSLVCNKTTE--DFEANKVRNREGCPKIYDENRVQLN-RPGHED--VNYINASVI
. .  .. |..|. |||   ..|..    . || .||     .||.||. |.  .||.|   .||||. |
hakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyi
0051299 (Phosphotyrosine protein) phosphatases II 207-494 3.6e-44 146.8 In-house 19-286 (288) alignment 
Range on Protein: 207-494
Range on HMM: 19-286/288.0
NNDIQKIREEFGFLDSLV--CNKTTEDFEANKVRNREGCPKIYDENRVQLNRPGH-EDVNYINASVITLKDVSrrmacvpayvhlvvlyfvifqfeHKLI
 |.. ...|||  | ||   .. ..  ...|. .||      || .||.|. ..  |. .||||| |.. . .                       .| |
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlk.......................rkfI

VAQLPQmenESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAP
..| |    .. ||||| |.........  . . . |....   .  . ||... |........ .| .| . .|.|| .     |.. | .....|.  
atqgPl...pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytn

WKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
| . . |. . ......... .  . ..  |.| .  |.||.. || ......||... .....|..| ...|||| |... |   .| ....|.
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 207-497 4.9e-11 37.3 In-house 11-279 (281) alignment 
Range on Protein: 207-497
Range on HMM: 11-279/281.0
NNDIQKIREEFGFLDSLVCNKTTE--DFEANKVRNREGCPKIYDENRVQLNRPGHEDvnyinasvitlkdvsrrmacVPAYVHlvVLYFVIFQFEHKLIV
.|| .   ||.  | ..  ..|..    ..|...||      ||  ||....  ..                        |.     .   .. |.. |.
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk....................ntDYin..anfvpgykgekeyia

AQLPQMEneSfVEDFWYMIYQEQINLVYLM---VPDDKLKntTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHApWK
.| |  .  | ...|| |......... ..   .  .|||      . |.|   .| |.. ... ..  .    | ....  |..    . |... | | 
tqgPvPa..s.lvafWqmvweqkvsaivmvtreieagklk..ChrYWPddnselky.gdvtvkstaeeekatyierkfkleresgetreveqlayta.WP

HLQQPPKTLPIIKMIHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARK
    | .|  ...  .. |. ..  ..| ...    | ||. ..|.   .......   | ............|   | . .| . .| .| |.. ..
dhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN12_pd Subfamily PTPN12 208-497 4.8e-16 53.5 In-house 15-280 (290) alignment 
Range on Protein: 208-497
Range on HMM: 15-280/290.0
NDIQKIREEFGFLDSLVCNKTTEDFEANKVRNREGCPkiYDENRVQLNRPGHED-VNYINASVITLKDVsrrmacvpayvhlvvlyfvifqfEHKLIVAQ
....|. |..   .    ...... . .| | ..  |  ||..||.|..  .|.  .||||..|   .                        ... | ||
qklkklsekykaekvysteagekeenvkknrykDilP..ydksrvelskieeeegsdYinanfikgveg.......................kleyiaaq

LPQMENesfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPkeYTIEVLPE--GNSDSVICQVHHHApWKHL
 |  .    ..||| ||.. ....| ..     |. .    .  |.|. .  .|.. ... . .   |   ..|  |     .   .. | |..| |   
gPLpkt...lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd..flirtLkveaqkesrkvyqfhYta.WPDh

QQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP---NICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARK
. | .. .....|... . .. ..| ..|    |.||.   |   |. ..|.... |   .. ... ....||.  | .  |   .|  | ... ..
gvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPN6_pd Subfamily PTPN6 211-498 2.5e-16 54.6 In-house 26-301 (306) alignment 
Range on Protein: 211-498
Range on HMM: 26-301/306.0
QKIREEFGFLDSLVCNKTTEDFE----ANKVRNREGCPKIYDENRVQLNRPGHEDVNYINASVITlKDVSRRmacvpayvhlvvlyfvifqfEHKLIVAQ
. . |||  |.   ..|. .  |     || .||  .   .|..|| |..|.  . .||||..|. |.|                       ... | .|
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyik.kevkgs....................dksyiatq

lPQMenESFVEDFWYMIYQEQINLVYLMVPD-DKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGD--PKEYTIEVLPEGNSDSVICQVHHHApWKHL
   .  |. |.||| |..||. ... ..  . .. |.  .  . ||.   . .||. ..| . .   |   .| ...   ....   . | |... |   
.gcl..ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks.WPdh

QQPPKTL---PIIKMIHQFLSEKQVQNAG-VCVVSLFGCGRACSFIGAL---YAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIAR
  | ..      .. ...  .| . ..|| ..|    | ||  .||        |..  . .. .| ...| ...|| | |   .|   .| ..  || .
gvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

KR
|.
kk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 211-491 1e-11 39.3 In-house 9-263 (283) alignment 
Range on Protein: 211-491
Range on HMM: 9-263/283.0
QKIREEFGFLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQLNRPGHedvNYINASVITLkdvsrrmacvpayvhlvvlyFVIFQFEHKLIVAQLPQM
.  || .  |     . . .  . ||  ||.     .| .||.|.   .   .||||. |..                        . ..| |.|| |  
klfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipv....................sksykqdkkyiiaqsPld

ENesfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNR--RADVSGDPKEYTIEVLPEGNSDSVICqVHHHAPWKHLQQPPK
.    | ||| |...|.|  . .. .    ..   | .  ..|  .| |.. .  |   .  |   || .. |    .|  ...  .    | . .. . 
rt...vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy.Geftvtlrkettsnsfiikelllrvnssakstllla.hyqvidWleygeqai

TLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVF
   ..|.       .. ... . |    | ||.  ||.|  .....      .. ...|....||.. | .  |   .. .|.
inslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
DSPc_SM00195 213-494 7.9e-52 171.5 In-house 2-262 (263) alignment 
Range on Protein: 213-494
Range on HMM: 2-262/263.0
IREEFGFLDSLV--CNKTTEDFEANKVRNREGCPKIYDENRVQLNRPG-HEDVNYINASVITLKdvsrrmacvpayvhlvvlyfvifQFEHKLIVAQLPQ
..|||  |..    ...|......|| .||    ..||..||.|...  .|. .||||..|...                       . ..| |..| |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.......................nkkkkyIatQgPl

menESFVEDFWYMIYQEQINLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP
   .| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | 
...pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
.| ......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....| . || .. .||
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 213-494 7.9e-52 171.5 In-house 2-262 (263) alignment 
Range on Protein: 213-494
Range on HMM: 2-262/263.0
IREEFGFLDSLV--CNKTTEDFEANKVRNREGCPKIYDENRVQLNRPG-HEDVNYINASVITLKdvsrrmacvpayvhlvvlyfvifQFEHKLIVAQLPQ
..|||  |..    ...|......|| .||    ..||..||.|...  .|. .||||..|...                       . ..| |..| |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.......................nkkkkyIatQgPl

menESFVEDFWYMIYQEQINLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP
   .| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | 
...pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
.| ......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....| . || .. .||
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 213-498 4.7e-47 156.1 In-house 2-278 (284) alignment 
Range on Protein: 213-498
Range on HMM: 2-278/284.0
IREEFGFLDSLVC----NKTTEDFEANKVRNREGCPKIYDENRVQLNRPGH--EDVNYINASVITLKDVSRRmacvpayvhlvvlyfvifQFEHKLIVAQ
..|||  | ||..    . ..  ...|. .||     .|| .|| |.....  || .||||| ..  |..                     ...| |..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldlt..................yikkkfIatq

LPQMEnesFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQ
 |  .    ||||| |.........  . . .  ...  . .  ..|.... |........ .| .| . .|.|. ..| .. |......|. .| . . 
gPlpn...tvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgv

PPKTLPIIKMIHQFLSEKQ--VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI---EPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARKR
|| . ........  .  .   ..  ..| .  |.||.. || . ....||...    .....|..| ...|||| |....|   .| ....|. .|.
ppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 215-495 2.6e-14 48.1 In-house 26-284 (305) alignment 
Range on Protein: 215-495
Range on HMM: 26-284/305.0
EEFGFLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQLNRPGHED-VNYINASVITlkdvsrrmacvpAyvhlvvlyfviFQFEHKLIVAQLPqMENe
...  | ..      .  |||| .||   . ..|..|..|.   ..|  .||||| .             .           .. ..| |||| | ..| 
aqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd............g...........ykrkkkyivaqgP.lkn.

sFVEDFWYMIYQEQINLVYLMV-PDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLP-EGNSDSVICQVHHHAPWKHLQQPPKTLP
  |.|||..|..|... . ...   .  |.     . .. .  .  |.. .. .      |  |  ...   .....|     ..   |     | ..  
.tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

IIKMIHQFLSEKQVQ-NAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
....|..   ... . .  . |.   | ||.  ||    |...|..  . .. |..|.....|.. |.. .|  ... .. ..| 
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
0045098 (Phosphotyrosine protein) phosphatases II 219-496 5.2e-23 77.3 In-house 17-274 (278) alignment 
Range on Protein: 219-496
Range on HMM: 17-274/278.0
FLDSLVCNKTTEDFEANKVRNREGCPKIYDENRVQlnrpghedvNYINASVITLKdvSRrmacvpayvhlvvlyfvifqfehKLIVAQLPqmeNESFVED
.| . ..  |.  .. |. .||      || .||          .||||| |.    ..                       | |..| |    .| |.|
lllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pk.......................kfIatqgP...lpstvad

FWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAPWKHLQQPPKT--LPI
|| |.....|. .  . .   |..     .  | ||... |......   .| .|    |..|        .  |   ...|  ||     |. .   ..
fwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf

IKMIHQFLSEKQV-------------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEpnICEIMKNIKQQRPG-GVESFAQCASIYAIVFDYIAR
.... . ..  ..             ..  | |    |.||.. ...| . . .|..|.   . |. | ...||||  |... |   .|  . ... |
lellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd..lleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 226-495 3.2e-40 133.7 In-house 2-247 (249) alignment 
Range on Protein: 226-495
Range on HMM: 2-247/249.0
NKTTEDFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITLKDVSRRMacvpayvhlvvlyfvifqfehklIVAQLPQMEnesFVEDFWYMIY
....  ...|| .||     .|| .||.|.  ||... .|||||.|.. ...||.                       |..| |  |    ||||| |..
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrf.......................iatqgPlpe...tvedfwrmlw

QEQINLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQ
...|. .  . ... |.. .   . .. ||... |........ .|..| . .|.|. . ....|. ... .. .| . . || . .....|.. ..  .
elgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkale

V--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
   ..  |.| .  |.||.. ||.|.....||.   . .. |..| ...||||.|... |   .| ...... 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPRN_pd Subfamily PTPRN 226-491 2.2e-08 28.1 In-house 47-289 (297) alignment 
Range on Protein: 226-491
Range on HMM: 47-289/297.0
NKTTEDFEANKVRNREGCPKIYDENRVQLNRP-GHEDVNYINASVITLKDvsRRMacvPAYvhlvvlyfvifqfehklIVAQLPQMeneSFVEDFWYMIY
 |.. . | |  .||.     ||..||.|..   .|. .|||||.|. .|   |.   |||                 | .| |     | | ||| |..
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd..pra...pay.................iatqgpla...stvadfwqmvw

QEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDP---KEYTIEVLPEgNSDSVICQVHhHAPWKHLQQPPKTLPIIKMIHQFLS
.. . ..  . . ..   . .. .  ..|   | .   ..     .  |    . . .  |   .    . | | .  |.. . |... .....  .   
eqGvvvivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfh.flswpeegvPasaksllefrrkvnk

EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI-EPNICEIMKNIKQQRPGGVESFAQCASIYAIVF
  . . . . | .  |.||.  .|     .|.|..|. | .|.  .. ...|||| |.. .|   ... | 
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 227-495 3.8e-21 70.6 In-house 48-291 (298) alignment 
Range on Protein: 227-495
Range on HMM: 48-291/298.0
KTTEDFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITlkdvsrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQMENesfVEDFWYMIYQ
|.    ..|| .||      .|  || |..  . |. .||||| .                         .. ..  |..| | .|    ||||| |. .
kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.......................aykgrnafiatqaPltet...vedFWrmvte

EQINLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFL-SEKQ
|.|. . .. .   |..|. . .  ..|  .| |.. .. .. .. .|    ...|  . ....   .  |.  |   . | ..  .......   |..|
edigtiVmltnleeldktkyhkywPdegkety.geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqq

VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
  |. | |    | ||. .||     ......     . ...| ....||| |.. .| . || .| ....
agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPRK_pd Subfamily PTPRK 228-492 5.7e-12 40.1 In-house 36-275 (314) alignment 
Range on Protein: 228-492
Range on HMM: 36-275/314.0
TTEDFEANKVRNREGCPKIYDENRVQLNRPGHE-DVNYINASVItlkdvsrrmacvpayvhlvvlyfVIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQE
 .   . |. .|| |    ||  ||.|     . . .||||..|                         ..  .. ||.| |  |    |.||| ..|.|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.......................dsykrpaafivtqgPlqe...tvkdfWrlvyde

QINLVyLMVPD--DKLKNTTTSLFNDENGGYQYTGKMFINNrRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSeKQ
.   . .|. .  .. .   .  . ..   |.    ....   ..     . ...| |  | ..  . .  ..  | . . | .   ..|....  . .|
ncasi.vmltelvevgrvkClkyWPedtevygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk.sq

VQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFD
 ..||  ||  . |.||.  ||     .. ...    .. ...|.......  ||   |   || ....
eeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 228-498 6.4e-09 30.2 In-house 36-275 (288) alignment 
Range on Protein: 228-498
Range on HMM: 36-275/288.0
TTEDFEANKVRNREGCPKIYDENRVQLNrpghEDV-NYINASVITlkdvsrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQmenESFVEDFWYMIYQE
. . | || .|.|       |  ||.|.    .|   ||.| |..                         .....|| || |    .. .| .| |. ..
iidsfianptrdryenlprcditrvkls....ddpdfyiaanvvs.......................sakykrrlicaqaPl...ngtieelWkmlles

QINLVYLM-VPDDKLKNTTTSLFNDENGGYQYTGKMF--INNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKHLQQPPKTLPIIKMIHQFlsek
... . ..    .| |. .   |  . |     |..   . ..|||.    |  .. .  ||.   .. ..| .  |..   | . |. ..... .    
dveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhll.eWdddgvPenylsplrllevl....

QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARKR
.  .  . | |  | ||.  .|  | |...|       | ..... ...|   ...  |   .. .|..... |.
kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_PTPN1_pd Subfamily PTPN1 228-489 8.1e-06 19.7 In-house 25-266 (290) alignment 
Range on Protein: 228-489
Range on HMM: 25-266/290.0
TTEDFEANKVRNREGCPKIYDENRVQLNRpghEDVNYINASVITLKDVSRRMACVPAYVHLVV--LYFVIFQFEHKLIVAQLPQMENESFvEDFWYMIYQ
.. ....|. .||    . ||  |..|.|   .|..|||||.. |... |.       .   |  .. .... . | .|     .|.|.    . |.  .
reaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi.kcaqywPqg

EQinLVYLMVPDDKLKNTttsLFNDENGGYQYTGKMFINNrradvsgdpkeytievlPEGNSDSVICQvHHHAPWKHLQQPPKTLPIIKMIHQFL-SEKQ
|.     |.. | ||| .   | . |.  |    .. ..|                  . .   .| . .|.  |  .  |      .|....   |   
ee..ekellledtklkvk...liseerksyytvrllelen.................lktqetreilh.fhyttwpdfgvpespaaflkflfkvresGsl

VQNAGVCVVS-LFGCGRACSFIGA---LYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAI
... |  |.    | ||. .|. .   |  |.. ..    .| . . .....| | .    |    |  
ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla
0049772 (Phosphotyrosine protein) phosphatases II 229-496 8.2e-16 54.1 In-house 40-282 (314) alignment 
Range on Protein: 229-496
Range on HMM: 40-282/314.0
TEDFEANKVRNREGCPKIYDeNRVQLNRPGHEDVNYINASVITLKdvsrrmacvpayvhlvvlyfvifqfeHKLIVAQLPqmeNESFVEDF---------
. |...|. .||      .| |||.|.. ......||||| .                              | |..| |   .|  |.||         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..........................lkfIatqgp...leitvvdfreepvlyyn

-WYMIYQEQINLVYLMVPDDKLKN---------------------TttslfndenggyqytgkmfinnR----------RadvsgdpkeytiEVLPEGNS
 | |. ....|. ..    |.                        .                                 .            |.| ... 
gwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng......................neptaadlellk............eelydpel

DSVICQVHHHAPWKHlQQPPkTLPIIKMIHQFLSEKqVQNAGVCVVSLFGCGRACSFIGALYAINQLnnGIepNICEIMKNIKQQRP-----GGVESFAQ
 .     ... |.    ..| .| ... . .|. |   ..  | |    |.||...|. | | . .|  |.  .. |... ....||     | .|.. |
ferlgikylripvpD.gsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleealedvrlkRpinpnpgfieqleq

CASIYAIVFDYIAR
   |. .. .|. .
yefilealleylkf
subfamily_PTPN14_pd Subfamily PTPN14 229-497 2.6e-09 31.5 In-house 43-299 (300) alignment 
Range on Protein: 229-497
Range on HMM: 43-299/300.0
TEDFEANKVRNREGCPKIYDENRVQLNRPGHEDVNYINASVITLKDVSRrmacvpayvhlvvlyfvifqfEHKLIVAQLPQmenESFVEDFWYMIYQEQI
|   . |. .||      |..|||.|.   ... .||||| |     ..                     |.. |||| |.   |  |.||| |......
taklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggk.....................ersyivaqgPl...eltvqdfWqmvWeqgv

NLVYLMVPD-DKLKNTTTSLFNDE--NGGYQYTGKMFINNRRADVS--GDPKEYTIEVLPEGNSDSVICQvhHHAPWKHLQQPPKTLPIIKMIHQFLSEK
.|. ..  . .. |. . . | ..  .      ||  . ..  . |     . .... || ..  .|.     .. |   . |.   . .. .... | .
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl..qytDWpdhgvPeDvkgflsyLeevqsvr

QV---------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARK
.          ..  | |  . | ||.   | .   |. |... | .| .... ...||   |...||   .| ..  |. . 
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
0042113 (Phosphotyrosine protein) phosphatases II 231-494 4.8e-39 129.6 In-house 5-243 (245) alignment 
Range on Protein: 231-494
Range on HMM: 5-243/245.0
DFEANKVRNREGCPKIYDENRVQLNRPGHE-DVNYINASVITlkdvsrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQIN
 ...|| .||   . .|| .||.|. .|.. |..||||| ..                        ... .|.|..| |. |    ||||| |.....|.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvd.......................gyritpkfiatqgPlpe...tvedfwrmlwelgit

LVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTLPIIKMIHQFLSEkqVQ
 .  . ... |.  .   .  . |.....|........ .. .| . .|.|| ..|.. |  ....|. || . . |.     | ........|.|   .
tivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..ds

NAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
|  |.| .  |.||.. ||.|.....||.   . .. |..| ...|||| |... |   .| ......
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 232-493 7e-25 83.4 In-house 7-241 (243) alignment 
Range on Protein: 232-493
Range on HMM: 7-241/243.0
FEANKVRNREGCPKIYDENRVQLnrpghEDVNYINASVITLKDvsrrmacvpayvhlvvlyfvifqfehKLIVAQLPQMEnesFVED----FWYMIYQEQ
...|. .||      || .|| |     |. .||||. |.  .                          .||. |.|  |    |||    || |.....
lpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp..........................rliatqgPlpe...tveddlasfwrmlwelg

INLVYLMVPDD-KLKNTTTSLFNdenGGYqYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKT---LPIIKMIHQFLSE
|. .  . ... . ..    ...   |.. . |......    . .| . .|... . . .  .   . .|. || . . |. .   | .......|..|
itvivmltelvElgrekcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefiee

-----KQVQNAGVCVVSLFGCGRACSFIGALYAINQLnngiEPNICEIMKNIKQQRPG-GVESFAQCASIYAIVFDY
     .  ..  |.|    |.||.  .| |.. . .|    . .. |..| ...|||| .|... |   .| ..  .
llsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 233-495 1.8e-13 45.2 In-house 45-279 (287) alignment 
Range on Protein: 233-495
Range on HMM: 45-279/287.0
EANKVRNREGCPKIYDENRVQLNrpghedvnyinasvitlkdvsrrmACVPAYVHLVvlYFVIFQFEHKLIVAQLPQMENesfVEDFWYMIYQEQINLVY
. || .||     ..|..|| |.                         . | |.  |  .   .. ... |.|. | ..    . .|| .| ..... . 
sqnkdknRltqilvpdnyrvllk........................gehpdyinav..fidgykekkafiiaesPmfnt...arnfWkliddrnvtaiv

LMVPDDKLKNTTTSLFNDENGGyQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFL-SEKQVQNAGV
... .   ..     .  |.    . |.  |.    .|. .  | ..||  .. ..|    . .. . |.   . ..   |. .|..   ....  |. .
mlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsi

CVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
 |    . ||.  |. |  .||. ..    .. ...|. ..|.|| |   .|   |. ||  |. 
vvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPN3_pd Subfamily PTPN3 234-483 1.8e-08 28.7 In-house 40-264 (280) alignment 
Range on Protein: 234-483
Range on HMM: 40-264/280.0
ANKVRNREGCPKIYDENRVQLNRpghEDVNYINASVITLKdvsrrmacVPAYvHLVvlyfvifqfeHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYL
.| ..||      ||. ||.|.    ....||||. . ..        .|.  .||           . |..| |    .. ..|||.|.......|. .
enlsknryrdilpydatrvklke...setdyinanyvnme........ipst.glv..........nryiatqGPl...aktatdfWqmvweqksslivm

MVP-DDKLKNTTTSLFNDENGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHApWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVC
.    .. .      . ...   .|. .. .. .. | .       . .  .  . .  | |. . | |   . | ..  .......  . .....  | 
lttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla.WpdhgvPddsadflefvervrklrsgkeePvv

VVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQC
|    | ||.  .|    |.  ...  . .. .|......||   |.. .| 
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqy
Y_phosphatase Protein-tyrosine phosphatase 235-491 1.4e-52 173.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 235-491
Range on HMM: 1-234/235.0
NKVRNREGCPKIYDENRVQL-NRPGHEDvnYINASVItlkdvsrrmacvpayvhlvvlyfVIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQINLVYL
|| .||  .  .||..||.| ...|..|  ||||...                         .. ..|.|..| |    .|..|||| |..||.......
nkkknRykdilpydktrvklkgsegpsd..YInAnyv.......................kgykekkkfIatQgP...lkstiedFWrmvwqekvkvivm

MVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNA
.. ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | .. .....|... ..|. ...
ltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVF
 |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..| . .|....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 235-491 1.4e-52 173.8 In-house 1-234 (235) alignment 
Range on Protein: 235-491
Range on HMM: 1-234/235.0
NKVRNREGCPKIYDENRVQL-NRPGHEDvnYINASVItlkdvsrrmacvpayvhlvvlyfVIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQINLVYL
|| .||  .  .||..||.| ...|..|  ||||...                         .. ..|.|..| |    .|..|||| |..||.......
nkkknRykdilpydktrvklkgsegpsd..YInAnyv.......................kgykekkkfIatQgP...lkstiedFWrmvwqekvkvivm

MVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNA
.. ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | .. .....|... ..|. ...
ltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVF
 |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..| . .|....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 237-496 3.2e-13 45.1 In-house 3-173 (182) alignment 
Range on Protein: 237-496
Range on HMM: 3-173/182.0
VRNREGCPKIYDENRvqlnrpgheDVNYINASVITlkdvsrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQINLVYLMVp
 .||      || .|         | .||||...                          .   . |..| | ..    |.||. |.....|...  .  
dknrysdilpydhsr.........dldyInanlyl.......................gslpatrfiatqgplls...tvadflrmlkelgittivnlt.

ddklkntttslfndengG----YqytgkM-FinnrradvsgdpkeytievlpegnsdSVICQVHHHAPWKHLQQPPkTLPIIKMIHQFLSekqvQNAGVC
                 .    .       .                                ... ||     |. .  ....|.. |.    ..  | 
.................eelywp.....ell..........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvl

VVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIAR
|    |.||......| . . .     . .. |..| ....|||.|..  |   .. ...... .
VHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 251-497 9.6e-08 26.3 In-house 36-267 (270) alignment 
Range on Protein: 251-497
Range on HMM: 36-267/270.0
RVQLNRPGHE-DVNYINASVITlkdvsrrmacvpayvhlvvlyfvIFQ-FEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVyLMVP--DDKLKNTTTS
||.|..  ..   .||||  .                         |.  ..| | |. |.   .. ...|| ||..|. . . .|.    .| ..    
RvrleeleedsataYinAnyvr.......................GfdgekkkYiaamgPl...pttlksfwrmiweekvtai.vmttgleEkgrkkCer

LFNDENGGYQYTGKMFINNRRADVSGDP--KEYTIEVLPEGNSDSVIcqVHHHAPWKHLQQPP------KTLPIIKMIHQF-LSEKQVQNA-GVCVVSLF
 .  |..    . ...|. .    . .       ...  .|..  ..   ...  |     |.      .|  ..||...   |||. ..|  . |    
YWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARK
| ||.  .|   .|.. |..  . .. .|.......|.  |.   | . .|. |  |. |.
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0051082 (Phosphotyrosine protein) phosphatases II 263-487 1.1e-07 27.1 In-house 4-146 (151) alignment 
Range on Protein: 263-487
Range on HMM: 4-146/151.0
NYINASVITLKdvsrrmacvpayvhlvvlyfvifqfehkLIVAQLPqmenesfVEDFWYMIYQEQINLVYLMVPDDKLKnTTTSLFNDENggyqytgkmf
.|||.| .|                              |.. . |        .||. ......|. .. . ...  . . ........          
dyinfsyvtgg............................lyrsggp.......ladflellkelgiktivnlrseeerg.ycpeylpelg..........

innrradvsgdpkeytievlpegnsdsvicQVHHHAPWKHLQQPPK---TLPIIKMIHQFLSekqVQNAGVCVVSLFGCGRACSFIGALYAINQlnngie
                                ..| |.   . |.    .  ........|.    .|  | |    |.||   .....  . .      
..............................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......

PNICEIMKNIKQQRPGGVESFAQCASIY
 .. |... ....||| | .. |   ..
vsleealeeyrlkrpgvvqpnqqflfql
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 269-496 8.9e-14 45.8 In-house 56-277 (303) alignment 
Range on Protein: 269-496
Range on HMM: 56-277/303.0
VITLkDVSRRMACVPAYVHLVvlyFVIFQFEHKLIVAQLPQMENESfveDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRA
|| | | |.   .  .|.|     .. .. ..| |..|||     .   ||| || ..... | |.. | . ..        .|  .    . .|     
vicl.dhskvklsdssyihas...yleldsskkailtqlplshtaa...dfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgef

DVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPK-TLPIIKMIHQFLSE--KQVQNAGVCVVSLFGCGRACSFigALYAINQLNNGIEPNICE
      . ... ||   | |   . .|||.  | | . | . .  ..| | |  |   |  ..     .|| ||||| .|  ||.   .|    | .  .
krvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtf..alfetahlslhseqasld

IMKNIKQQRPGGVESFaQCASIYAIVFDYIAR
..| ... | | . .  |  | ...|.  .| 
lvkclenvrngrlhav.qnlsqfsvvytllae
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 270-495 7.4e-15 49.6 In-house 63-284 (290) alignment 
Range on Protein: 270-495
Range on HMM: 63-284/290.0
ITLKDVSRRMACVPAYVHLVvlYFVIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRAD
|||...| .  |   |.. .  |   .. ... |..| | ..    . ||| .|.||..  . ...   . ....   .  ...  .  |.. |.     
itLrpisghkDCtneyinAc..yikgykekkqyiatqgpvsn...tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllnee

VSGDPKEYTIEVLPEGN--SDSVICQvHHHAPWKHLQQPPKTLPIIKMIHQFLS-EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIM
.  .  | ..||  . .  . . . | ..   |..  . ...  |. .|..    ...  |  . |    . ||.  |. |  .||. .     .. ...
tlneyierklevknknsagakqsvtq.yqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvl

KNIKQQRPGGVESFAQCASIYAIVFDYIA
|. ..|.|| |..  |   |. ||. |. 
ksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 279-494 1.8e-06 21.7 In-house 70-279 (439) alignment 
Range on Protein: 279-494
Range on HMM: 70-279/439.0
MACVPaYVHLVVLYFVIFQFEHKLIVA-QLPQMENesfVEDFWYMIYQEQI-NLVYLMVPDDKLKntttslFNDENGGyQYTGKMFInnrRADVSGDPKE
.  || . | .   ..   .. || .| | |. |.   ..||| ......  ..| |    .  |      .   ..   . | . .   |.|   .  .
ipgvp.hshyinanyikGyyddklyiatqgpkket...tddfwrlviekktvtivmltnlvesyk......ywpsdae.vcygdiav...rvdrnielpn

YTIEV---LP---EGNSDSVICQVHHHApWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVS-LFGCGRACSFIGALYAINQLNNGIEPNICEIMKNI
|.|     .     .. .  . |.|. | | . . | ..  ......   | .. .. |  ||    | ||. . |    |..||.   . .|  |.| .
yvirgfkvfnerdttekertvlqfhyia.wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvl

KQQRPGGVESFAQCASIYAIVFDYI
..||   |....|   ||  |.. |
rkqrkqmvqalcqyvfiynavledi
0044763 (Phosphotyrosine protein) phosphatases II 290-488 1.8e-08 29.7 In-house 27-165 (178) alignment 
Range on Protein: 290-488
Range on HMM: 27-165/178.0
VlyfvifqfeHKLIVAQLPQmenesfvEDFWYMIYQEQINLVYLMVPDDKLKN--TTTSLFNDENggyqytgkmfinnrradvsgdpkeytievlpegns
.         . |....||.       .|.. ..... |...  . ... |    .    . ...                                   
l.........pglylgslpp.......addlellkelgithivnlteelelgflkcdpywpeeag...................................

dsvicQVHHHAPWKHLQQPPkTLPIIKMIHQFLSEKQ-VQNAGVCVVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPgGVESFAQCASI
       ..| |.     |.  | ..  ...|. | .  ..  | |    | ||..... | . . .       .. |... ....|| .|... |   .
.....iqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqL

YA
| 
ye
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 295-492 3.1e-13 44.8 In-house 63-253 (284) alignment 
Range on Protein: 295-492
Range on HMM: 63-253/284.0
IFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIE---VLPEGNS
 .| ..| | .| |.   .  ..||| ||.. ..  . |.               ...    .  |. |.. | .|      . .||..    .  .|. 
GyqrkdkyiatqGPl...dntladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgke

-DSVICQVHHHAPWKHLQQPPKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCA
 |    . .|   | .  .|  . ........   |..|. ..| . |    |.||.  .|     ......    .. .......|||.  |....|  
kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

SIYAIVFD
 ||. . .
fiysalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 295-492 4.5e-13 44.2 In-house 99-289 (319) alignment 
Range on Protein: 295-492
Range on HMM: 99-289/319.0
IFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIEV---LPEGNS
 .| . | | || |.   .  ..||| ||.. ..  . |.                .     .  |. |.. | .|      . .||..       .|. 
GyqrkdkyiaaqGPl...dntladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgke

-DSVICQVHHHAPWKHLQQPPKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCA
 |    . .|   | .  .|  . ........   | .|. ..| . |    |.||.  .|     ......    .. .......|||.  |....|  
kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

SIYAIVFD
 ||. . .
fiysalle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 295-494 6.5e-09 29.7 In-house 83-236 (392) alignment 
Range on Protein: 295-494
Range on HMM: 83-236/392.0
IFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQINLVyLMVPddKLKNTTtslfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQV
 |. |.  | .| |   | . ..||| |..||..  .  ||   |||.                                          |...  ..| 
sfdnekayiasqgp...naaslddfwrmvfqenvtti.amvt..klkegd.......................................kgddartvaqf

hHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
 | . |   . | .|  ..|.|..  ..       . .    | ||.   |     . . ..    .. ... ||...||  |..  | | ||. |.. .
.hftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 296-497 5.9e-56 184.1 In-house 86-288 (302) alignment 
Range on Protein: 296-497
Range on HMM: 86-288/302.0
FQFEHKLIVAQLPQMENESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPK-EYTIEVLPEGNSDSVICQV
 ......|.||||... |. ||.|| |..||.|  |...| ...||.|   ||  . | |.. ||||.|||. . . . | .|.||||||| |.||...|
PeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv

HHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
 ..  ||. . | |   .|| ...   .|.  .. . .||  |.||| .|. .  |...|..| |||| ||.|.|..|||  |.|. | .|.| ..  ||
yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

ARK
 .|
kkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 296-495 2e-11 38.5 In-house 87-284 (319) alignment 
Range on Protein: 296-495
Range on HMM: 87-284/319.0
FQFEHKLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVP-DDKLKNTTTSLFNDENggYQYTGKMFINNRRADVSGDPKEYTIEVlpEGNSDSV---I
.| ..| | .| |    |  .|||| |...|..  | ..    .|||     ....||  ..  |.. ..    .   |     ...  . .|. |    
yqerekfiatqaPl...entiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl..nkkssevetRe

CQVHHHAPWKHLQQPPKTLPIIKMIHQFLSE-KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIV
 . ...  |   . | |.. .......     .. |.  . |    | ||  .||    .......    .. ....... ||.  |.  .|   || ..
vkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeal

FDYIA
 ... 
leave
subfamily_PTPRG_pd Subfamily PTPRG 296-497 9.7e-10 32.3 In-house 87-290 (563) alignment 
Range on Protein: 296-497
Range on HMM: 87-290/563.0
FQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQINLVyLMVPD--DKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLP----EGNS--
.| ... |..| |  .    ..||| ||.... ...  |...  .. ..     .     . .  |.. ..  . .|   . . |. .      ....  
yqkskafiatqgplkd...tfddFWrmiWeqnvaii.vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcd

DSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFlSEKQVQNAG-VCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASI
.    . .| . |   . | ..|| ......  |  . ..|| . |    | ||.  .|     ..|...    |. ...| |. ||.  |..  |   .
teklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYifl

YAIVFDYIARK
. .. . || |
hdalleaiask
subfamily_PTPRA_pd Subfamily PTPRA 297-494 2.4e-13 44.7 In-house 98-295 (330) alignment 
Range on Protein: 297-494
Range on HMM: 98-295/330.0
QFEHKLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTG-KMFINNRRADVSGDPKEYTIEVLPEGN---SDSVIC
.  .| | || |. |    ||||| ||.. .   . ..   .. |..    .  ..| . |   .. ...    |.   ... .. ||..    .  .. 
kekdkfiaaqGPkeet...vedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvr

QVHHHApWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFD
|.| .. | ..  | ..  ..|....  . .|..   . |    | ||. .||     .....     .. |..|....|||  | .  |   || .. .
qfhfts.wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

YI
| 
yy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 297-495 3.5e-13 44.3 In-house 89-285 (297) alignment 
Range on Protein: 297-495
Range on HMM: 89-285/297.0
QFEHKLIVAQLPqmeNESFVEDFWYMIYQEQINLVyLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVH
 ..|.||  | |   ... |.||| |...||.. . .|. ||. ..     .  ..|  .  |.. .     .      . ..||  .   .  |. | .
gnkhrlittqmP...mkatvadfWamvldeqvsti.vmlnddnerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyq

HH-APWKHLQQPPKTLPIIKMIHQFLSEKQVQNA-GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDY
.   | |  ..  ..  ..|.|..   . . ..   . |  | | ||.  ..  .  . . ..  | .| ...| ..|.||  |    | . .| .| ..
fveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

IA
. 
ll
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 297-494 1.1e-12 42.6 In-house 87-279 (288) alignment 
Range on Protein: 297-494
Range on HMM: 87-279/288.0
QFEHKLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMVPD-DKLKNTTTSLFNDENGgYQYTGKMFINNRRADVSGDPKEYTIEVLpEGNSDSVICQVH
. ..| | .| | ..    |.||| ..|..... .  .    .. |..    . |..   .  |.. .  .     .|  . ....    ...  | | .
kkkkkyiatqgPladt...vndfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrkllle.kkkteleitqyq

hHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
 .  |   . |  . |......|    .| .   . |.   | ||.  || .  .|.....    ...........||.  |.   |   || .. . |
.ylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 297-491 2.6e-10 34.7 In-house 89-276 (315) alignment 
Range on Protein: 297-491
Range on HMM: 89-276/315.0
QFEHKLIVAQLPQMeneSFVEDFWYMIYQEQINL-VYLMVPDDKLKNTTTSLFNDENGGYqytGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIcQVh
. ... | || |..   . |.||| ....|.|   | |    .. |. .   . |..  |   ||. .  .  .|  .    |. |  . |   |. |. 
nkkrryiaaqgpnv...asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy...Gkitvtrkseevnteytvrtlsvvfgdnirevv.ql.

HHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVF
|.. |   . |  |.|....| .    .. . . . |    | ||. .||     ..|..     .. .......|.| . |.. .|   || ...
hytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_PTPRB_pd Subfamily PTPRB 297-497 2.2e-08 28.5 In-house 91-288 (293) alignment 
Range on Protein: 297-497
Range on HMM: 91-288/293.0
QFEHKLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMV-PDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPeGNSDSVICQvH
. ... |..| |  |    |.||| |..... . . ..    .| |      . ...   .| |.. ..    ..  |    ....   ...   . | .
nsprefiatqGPlpet...vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvly.Gdikvtlvaeeeledwvirelkiek.ekeerkvrq.y

HHAPWKHLQQPPKTLPIIKMIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDY
|.  |     | || ......... ...  . ... . |    | ||.  ||     ......    .|. |. .....|   | . .|   |.  | |.
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

IARK
. .|
lrkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 299-495 1.3e-15 52.3 In-house 51-243 (250) alignment 
Range on Protein: 299-495
Range on HMM: 51-243/250.0
EHKLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHA
..  |..| |  .    .|||| |...|... . ..      ..| .  .   ..  .| |.. ..    .. .| .  .. .  . ..|..| .  |. 
rkafiatqgPlqat...iedfWrmvleeksgtivmLtnLkesektyhqywP.vekaeky.Gdvtvsllskeefadytkrklklskakkaderivrqlhfv

PWKHLQQPPKTLPIIKMIHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
 |     | ..  .......  ...|  .|| | |    | ||. .||     ...|..    .. ...| ....||. ||| .|  ..| |.  .. 
vWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0051429 (Phosphotyrosine protein) phosphatases II 299-496 6e-08 28.2 In-house 21-227 (272) alignment 
Range on Protein: 299-496
Range on HMM: 21-227/272.0
EHKLIVAQLPQMENesfVEDFWYMiYQEQINLVYLMVPDDKLKNTTTSL-----------FNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GN
...|. .. |   .   ..|||.. ....|. .  . ... ..   ...           ..|.       |.... .    .  |   .....  . ..
pgrlyrsggplplt...aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

SDSVICQVHHHAPWKHLQQPPKTlpIIKMIHQFLSekqvqNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPN--------ICEIMKNIKQQRPGGVE
...    . |.  |     |...  ........|.     .  | |    |..|   .. .|. . ...     .        . |... ...|||| |.
gearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavq

SFAQCASIYAIVFDYIAR
. .| . .| .. ... .
teeqylflyeallellrs
subfamily_PTPN13_pd Subfamily PTPN13 299-491 1.5e-07 26.0 In-house 76-266 (273) alignment 
Range on Protein: 299-491
Range on HMM: 76-266/273.0
EHKLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLF--NDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHH
|.. |..| |  |    |.||| |... . ... ..  .   ..     .  . .|   . .... ... .     . .  ...|     ..|   .  .
eyeyiacqGPlPet...vkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahln

HAPWKHLQQPPKTLPIIKMIHQFLSEKQvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVF
 . |   . | ......... .  . .. ... . |    | ||. ..|    ... ...  | .. ||......|| | | .  |   .| .. 
fvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
0043147 (Phosphotyrosine protein) phosphatases II 300-487 2.2e-11 39.3 In-house 20-154 (172) alignment 
Range on Protein: 300-487
Range on HMM: 20-154/172.0
HKLIVAQLPqmeNESFVEDFWYMIYQEQINLVYLMVPDdklkntttslfndenggyqytgkmfinnrradvsgdpkeytievLPEGNSDSVICQVHHHAP
...|. | |     . ..||| |.....|.... . .                                             |  .   .     ... |
drfiatqgp...lrntladfwrmlkelgithivnltel............................................lydpellerlgiqylylp

WKHLQQPpkTLPIIKMIHQFLSE--KQVQNAGVCVVSLFGCGRACSFIGALYAInqlnNGIepNICEIMKNIKQQRPGGVESFAQCASIY
|     |  .| ..  . .|. |   . ..  |.|    |.||.. .. |.. .     |.  .. |... ....|||.|... |   .|
wpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl..sleeavalvrekRpgavqnpsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 300-487 5.1e-10 34.8 In-house 17-163 (174) alignment 
Range on Protein: 300-487
Range on HMM: 17-163/174.0
HKLIVAQLPQMenesfvedFWYMIYQEQINLVYLMVPDDKLKNTTT-----SlfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQV
 .||. | |          ||.|.....|. |  . .   |...       .                                       .. .     
prliagqgpla........fwemlkelgittvvmlleekelglykcinywpe.....................................lredlerlgiq

HHHAPWKHLQQPP--KTLPIIKMIHQFLSEkqVQNAGVCVVSLFGCGRACSFIGALYAINQLNngiePN---ICEIMKNIKQQRPGGVESFAQCASIY
... ||   . |.  . | ..| ....|||   ..  | |    |.||.  ...|.. . .|     ..   ...... ...||||.|... |   .|
ylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_CG7180_pd Subfamily CG7180 301-494 5.1e-14 46.6 In-house 86-290 (296) alignment 
Range on Protein: 301-494
Range on HMM: 86-290/296.0
KLIVAQLPQmenESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSlFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPE----------GNSDSV
. || . |.   .. |..|| ..|.|.|. |  .      ..   | .  ...  || |..|..  . .   . | .|. .  .           . .  
eyivteapk...ketvdefWrlvydeeisavvvLtktfdfakmyps.ywpnkskeqy.geifveiveekqyanlkirtfkltkkivalteqekqvkaetR

ICQVHHHAPWKHLQQPPKT----LPIIKMIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCA
|... .   |.  .. |      . ........  .   . ... |.|||  | .|.  ....  .......  | .. | .| ....||. ||.  .  
ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYk

SIYAIVFDYI
 || .. ...
yiYdvlleav
subfamily_PTPN23_pd Subfamily PTPN23 301-495 1.1e-13 45.6 In-house 84-281 (288) alignment 
Range on Protein: 301-495
Range on HMM: 84-281/288.0
KLIVAQLPQmenESFVEDFWYMIYQEQINLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVhHHA
..|..| |.   .| . ||| |.|... ...  |. .... |. . . .  ..|  .  |.. .  ..   ..   |.....  ....    .. . .  
dfiatqaPl...qstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshl.qlt

PWKHLQQ---PPKTLPIIKMIHQ-FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN--NGIePNICEIMKNIKQQRPGGVESFAQCASIYAIVFD
 | .|     | . | ... ... . ....  .. . |  . | ||.  |     |...|.  ||. ..| .... ...||   |.  .|    | .|  
sWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngl.ldiiqvvsrlreqRrfmvqekeqlkfsyeavle

YIA
.. 
aar
subfamily_PTPRD_pd Subfamily PTPRD 301-521 3.1e-12 40.9 In-house 92-305 (564) alignment 
Range on Protein: 301-521
Range on HMM: 92-305/564.0
KLIVAQLPQMENesfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPW
. | .| |  |    .|||| |....... . ..      ...  . .  |.|  .| |.. ..        |    |...  . .|.|   .  |.  |
ayIAtqgPlaet...iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsW

KHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARkrGG
 .  .| .. .....|..  . .. ..  . |    | ||   ||   . ......    .| ...|....||.  |..  | . |. .. ...|   | 
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac..gn

KKAPVnKDINRFIDELAEISP
.. .. ..... ...|||...
teves.enlkqhlqkLaevee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 301-524 8.4e-11 36.5 In-house 90-307 (318) alignment 
Range on Protein: 301-524
Range on HMM: 90-307/318.0
KLIVAQLPQMENesfVEDFWYMIYQEQ-INLVYLMVPDDKLKNTTTSLFnDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAP
. | || |  |    .|||| |... .   .| |    .. |.     .  ..|  .| ||. .. .    ..|    ...|  .....| . . .|.. 
ayiaaqaPlpet...ieDfWrmvWeqnsavivmltqeeergkakvhryW.Pskgsrsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhyts

WKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIARKR
|     | ..  ..... |  . .| ..||. ||    | ||.  ||     ......    .. ...|....||.  |    |   || .. ...|   
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

GGKKApvnKDINRFIDELAEISPACS
   .|   .|... | || | .|   
tevda...sdlrsrirelreqdpesg
subfamily_egg_pd Subfamily egg 301-518 1.4e-08 28.8 In-house 84-293 (307) alignment 
Range on Protein: 301-518
Range on HMM: 84-293/307.0
KLIVAQLPqMENEsfVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPKeYTIEVLP-EGNSDSVICQVHHHA
..|.|| | . |   |.||| |..||... . ..    . ..      . |.   ..  | . |.| . |   ||  ...  |   |  |      |   
efilaqap.lknt..vddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadpl.frvtklklvGgddeerflehwqg

PWKHLQQPPKTLPIIKMIHQflsekqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNG--IEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIaR
 .... .    | ..... .           | | .  |. .|.... .  |. .|  |      . . .. ....|.  |||  .   .| .|  .. |
dvnnssdvysplrvlrklrn.......lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff.r

KRGGKKAPVNKDINRFIDELAE
   |    .. | .|...| .|
dvigsakeldvdyerwleerse
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 308-495 1.9e-13 45.0 In-house 92-278 (315) alignment 
Range on Protein: 308-495
Range on HMM: 92-278/315.0
PQMENESFVEDFWYMIYQEQINLVYlMVPDDKL--KNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIeVLPEGNSDSVICQVHHHApWKHLQQ
 |. ... |.||| |..||..  .  || . .   |      . |...     |.. ..    .  .|     . |. ....   . | . .  | .   
sqgPlkasvddfwrmvlqekvttiv.mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqfte.wPdkGv

PPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIA
. .|  ..|.|..  .... ..  . |  . | ||.  .| .   ..|....   .. ...||....||  | .  . | || .| ... 
dkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 308-494 2.5e-09 31.7 In-house 96-288 (325) alignment 
Range on Protein: 308-494
Range on HMM: 96-288/325.0
PQMENESFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWK--HLQQ
 |. . . ..|.| .... .  .| ..   |. |.  .  . .| |  .  | . .. | ..   |     ..|    . ..   .  ..  |.    |.
aqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqk

PPKTLPIIKMIHQFLSEKQV----QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
 | ||  |  . . .||.        . . |    | ||.  ||    |.... .  . .| . .|.....||  ||.  |   ||  . ...
rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 314-496 1.5e-13 45.5 In-house 84-270 (274) alignment 
Range on Protein: 314-496
Range on HMM: 84-270/274.0
SFVEDFWYMIYQEQINLVyLMVPDDKLKNT-TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPKTLP
. |.||| |||||..... .|. . | .|    . .  .. .|. ...    . . .   . ..|... |   .. .   .. . .. |   ..| .. .
ntvadfWrmiyqeevqvi.vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddant

IIKMIHQFLS---EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYIAR
.......  .   |.. . | | |    | ||.  ||... |..||.. |  .. .|. |....| | |..  |   |. ..  |  |
lldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0046846 (Phosphotyrosine protein) phosphatases II 314-490 1.1e-10 37.1 In-house 34-169 (176) alignment 
Range on Protein: 314-490
Range on HMM: 34-169/176.0
SFVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDENGGYQYtgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKtlPII
. ..||. |.....|..|  .  .  |.      . .|  ....                                     ..| ||   . |.    ..
rtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl..ell

KMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnnGIEPNICEIMKNIKQQRP-GGVESFAQCASIYAIV
  . .|. | . ..  | |    |.||.. .. |.  .     .   .. |... ...||| | |....|   .|  .
lellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 315-494 1.1e-10 35.9 In-house 87-270 (285) alignment 
Range on Protein: 315-494
Range on HMM: 87-270/285.0
FVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNDEN-GGYQYTGKMFIN---NRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPK-T
 . |||.|||||.|  | ...   .      .|.  |. |     ||  |     .   ..|   .    .  |  |   .   | . ||   |  |. .
tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapeda

LPIIKMiHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQCASIYAIVFDYI
 |.|.. .... . . ..  .||    | ||...|.|  ||  .. .  . .. .|.....  |   |.|. |   .| ....|.
rpmiel.ykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0049260 (Phosphotyrosine protein) phosphatases II 315-487 4.8e-10 34.8 In-house 21-143 (152) alignment 
Range on Protein: 315-487
Range on HMM: 21-143/152.0
FVEDFWYMIYQEQINLVYLMVPDDKLKNTTTSLFNdenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKTLPIIK
 ..||| |... .|. .  .  .. |.   .                                                 ..| ||     |. .  .. 
tladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllf

MIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAInqlnngIEPNICEIMKNIKQQRPGGVESFAQCASIY
...     .. ..  | |    |.||.  .. |.. .         .. |... ....|||.|... |   .|
lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 345-477 7.7e-06 19.6 In-house 178-321 (347) alignment 
Range on Protein: 345-477
Range on HMM: 178-321/347.0
TSLFNDENGGYQYTGKMFINNRRADVSGDPK----EYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTLPIIKMIHQFLSEK----QVQNAGVCVV
.|.|  |   |      .|| |. .|    |     ||.||. || |.. ...|.  . |   . |    | | ...   .  |        . | | |.
ssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvm

SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGV
  .|  |... . .   |.|. .|  |.  ...|....|| |  
cdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvf
0048179 (Phosphotyrosine protein) phosphatases II 381-487 1.7e-07 26.6 In-house 36-138 (144) alignment 
Range on Protein: 381-487
Range on HMM: 36-138/144.0
VLPEGNSDSVICQ--VHHHAPWKHLQQPPKTLPIIKmIHQFLSEK-QvQNAGVCVVSLFGCGRACSFIGALYAInqlNNGiePNICEIMKNIKQQRPGGV
. .|   ......   ..| ||   . |. .  ... . .|. |  . ..  | |    |.||..... |   .    .|   .. |... ....|||.|
lteeyepefleregiqylhlpwpDhgvpdllellle.flefieeale.eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgav

ESFAQCASIY
... |   ..
pnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 386-489 2.3e-07 26.1 In-house 41-138 (145) alignment 
Range on Protein: 386-489
Range on HMM: 41-138/145.0
NSDSVICQVHHHAPWKHLQQPPKTlPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnngIEPNICEIMKNIKQQRPGGVESFAQCAS
.  .     ... ||   . |. .  ..  . .|. | . ..  | |    |.||......|   .         .. |... ...||||.|... |   
ellerlgiqylylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

IYAI
.|  
lyef
PTPc_DSPc_SM00012 393-490 3.3e-18 61.2 In-house 3-103 (105) alignment 
Range on Protein: 393-490
Range on HMM: 3-103/105.0
QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQ--NAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQCASIYAI
.. |.  |.. . | .. .|....... ..|. .  .. |.|..  |.||.. |. . ....||...  |..|..|.| ...|||| |....|   .|..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

V
.
l