Gene C15H7.3 in Caenorhabditis elegans

Synonym: CELE_C15H7.3, CELE_C15H7.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP017_AA protein Get Run
CeleP017_AA_109-378 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 99-393 7.1e-120 394.0 In-house 2-301 (302) alignment
Range on Protein: 99-393
Range on HMM: 2-301/302.0
KKEEVKEPWSEEEPAKRMVANgfFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPD
|.|| ||.|.||| ||..|..  ..|..|  .||..|..|.....|..||.|..|....|.||....||||.. |.|...|.|..||...|..||.|.|.
kveeekekWveeeeakklvks..ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpk

LSSAPDIADFWRMIHQESIASVVIAVMPLEV--TLQQILPLLSGTYSTYGKMFVNNKKVESAVGMT-EYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEV
..|......||||..||.|.||||.|.. |.  ||....|..||.|..||||||||.|||.|.... .|..|..|.|||||.|..||.|.||.||.... 
vdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvk

VTDLVATMEKV----MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVV
...|..|..||    .|...|||..|.||.||||..|||..|. ..|||||.|.||...|.|..|. .||...|. ..........|.. |..|...|..
yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkke

EF
|.
ev

0050432 (Phosphotyrosine protein) phosphatases II 100-382 3e-51 170.0 In-house 19-304 (308) alignment
Range on Protein: 100-382
Range on HMM: 19-304/308.0
KEEVKEPWSEEEPAKRMVAngFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLtNGPESFICAAKITVP--DFNRTMILTQV
   .....| .. .|..     . ....   |..  ..|.... |. ....|..| | .|... .   ||| ... ..|.|  ....  ...|..|.|| 
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqg

PDLSsapDIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRG
|  .    ..|||||.... .  .|    . |   ..  |  ||  | .. .|||..|.....|.  ..| . ||. . |...|.  |..| .||     
Plpn...tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv

LEVVTDLVATMEKVMKV--NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
 . ...|.. .|.| |.  . ..| ....| ||.||...| ... |..|...|.. |... ||  |.| | . .|.  ..| .....|.  |
PpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

0039614 (Phosphotyrosine protein) phosphatases II 101-380 6.7e-44 145.9 In-house 10-292 (297) alignment
Range on Protein: 101-380
Range on HMM: 10-292/297.0
EEVKEPWSEEEPAKRMvaNGFFTTTNVGGTFKQTDNFKTPmDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPE-----SFICAAKITVPDF-NRTMILT
| . .|.| .. ....  .  . .| .   |..  ..| .  |.  ...|..| | .|... .   |||.  ..     ..|.|  ....|. .|..|.|
esipiplsvldlllll..ekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QVPdLSSapDIADFWRMIHQESIASVVIAVMPLEVT--LQQILPLLSGtysTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSnsLLTTVYHLHNWRQKRG
| | |..   ..|||||.... . ..|    . |     .|  |  .|   |||...|...|||   |.| . ||. ..|.|  .  |... ..|     
qgP.lpe..tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgv

LEVVTDLVATMEKVMK------VNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNN
 . ...|   .|.|..       .  .. ....| ||.||........ |..|...|...|... ||  |.|.| . .|.  ... .. ..|..
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0051299 (Phosphotyrosine protein) phosphatases II 106-378 1e-46 155.1 In-house 4-287 (288) alignment
Range on Protein: 106-378
Range on HMM: 4-287/288.0
PWSEEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTN----GPESFICAAKITVPDFNRTMILTQVPDLS
..| || .|.. .     .|..   |..  ....... |. ....|..| | .|..  .   |||..    .. ..|.|  |......|..|.|| |  .
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

sapDIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD----GCSNSLLTTVYHLHNWRQKRGL
    ..|||||.... .  .|.   . |   ..  |  ||  |.. |||...|.....|.  ..| . ||. .     |...|.  |..| .||      
...tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

EVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
. ...|.. ...|.|.    .  .| ....| ||.||...|.... |..|...|.. |... ||  |.|.| . .|.  |.. .. ..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk

0040438 (Phosphotyrosine protein) phosphatases II 107-392 5.1e-53 175.8 In-house 3-291 (317) alignment
Range on Protein: 107-392
Range on HMM: 3-291/317.0
WSEEEPAKRMVANGFfttTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssA
.....  .......|   | .   |.. ...| .  |. ....|..| | ||... .   |||.. .     ..|.|  ...|...|..|.||.|     
ldlllalldllksdf...talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...p

PDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDL
  ..|||||.... . ..|  . . |      .|  ||  |.. |||...|.....|   |.| ..||. ..|.|.|.  |..| ..|      .  ..|
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

VATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVVE
.. .|.| ..    .  .. ....| ||.||........ |..|...|...|... ||. |.|.| . .|.  ... .....|.. | |........
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk

0043336 (Phosphotyrosine protein) phosphatases II 107-377 3.6e-46 153.3 In-house 2-277 (278) alignment
Range on Protein: 107-377
Range on HMM: 2-277/278.0
WSEEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDLSsa
.| .. .|...  ..   | .   |.. ..||... |.  ...|..| | .|... . ..|||.. .     ..|.|  .......|..|.|| |  .  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe..

pDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVAT
  ..|||||.... . ..|  . . |   ..  .  .|.. |||...|...|.|.  ..| . ||. . |...|.  |.|| ..|      | ...|.  
.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

MEKVMK----VNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
...|..     |  .. ....| ||.||...|.... |..|...|.. |... ||  |.|.| . .|.  ... .....
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 129-391 3.7e-53 176.1 In-house 17-291 (297) alignment
Range on Protein: 129-391
Range on HMM: 17-291/297.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
  |.. .... ... |. ....|..| | .|... .   |||.... ..|.|  ....|..|..|.|| |  .    ..|||||.... . ..|  . . 
kefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmltelv

E---VTLQQILPLLSGTYSTYGKMFVNNKKVES--AVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLM
|   .. .|  ||  | . |||...|....||.    ..| . ||. . |...|.  |..| ..|      | ...|.. .|.| |       .  .. .
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

SMNGTGRAGTMLTLFTAMLQVQ---KGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVV
...| ||.||........ |..   | ..|. .|.. .||  |.|.| . .|.  ... .....|.. | |.....|.
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl

0047943 (Phosphotyrosine protein) phosphatases II 129-377 1.3e-48 161.2 In-house 16-272 (273) alignment
Range on Protein: 129-377
Range on HMM: 16-272/273.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
  |..  ..|.... |. ....|..| | .|... .   |||..|. ..|.|  .......|..|.|| |  .   ...|||||.... .  .|  . . 
eefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvrviVmLtelv

E---VTLQQILPLLSGT-YSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMS
|   ..  |  ||  |. . ||||..|.....|.  ..| . ||. . |...|.  |..| ..|      . ...|.  .|.|.|       |  .| ..
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
..| ||.||...|.... |..|...|...|... ||  |.|.| . .|.  ... .. ..
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 129-381 8.5e-14 45.9 In-house 26-283 (303) alignment
Range on Protein: 129-381
Range on HMM: 26-283/303.0
GTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNgpESFICAAKITVpDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE
  |..  ..  |  |   | .||.| |  |    .   |||..   |.| |. . . | ..  ||||.|   .|   ||||.|| .. .  |.. .   |
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd..ssyihasylel.dsskkailtqlplshta...adfwqmiieqkvkcvlllltdse

VT---LQQILPLlSGTYSTYGKMFVNN---KKVESAVGMTEYCLEIfPDGCSNSLLtTVYHLHNWRQKRGL-----EVVTDLVATMEKVMKVN--DNTVL
      . ..|     .  . . ..     |.|| . | .   | .  .|  .|.|  |.| ..| ..        ..| ..      . |      || 
ydklggdsvfpr.nqdflkfeersirvgefkrvelgdgwvlkvlsv.sngdyksfl.hvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvy

MSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
||. | |||||.  . || | ...    ..    |  .|  |   |.|. ||  |.  .|    .| 
mslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng

subfamily_PTPN13_pd Subfamily PTPN13 131-371 4.3e-12 40.9 In-house 17-263 (273) alignment
Range on Protein: 131-371
Range on HMM: 17-263/273.0
FKQTDNFKtPMDSCPSFKN--NMHKIRAPDCPIPEEKLVKLTNGPEsFICAAKIT--VPDFNRTMILTQVPdLSSApdIADFWRMIHQESIAsvVIAVMP
||.  ..| |.|.| . |.  |..| |  .    .|  ||| .    .| |. |   | . . ..|..| | |  .  ..|||.|. . .    |||.. 
fkelrelk.pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGP.lPet..vkdfwqmvweqkae..viamvt

LE-----VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND---NTVLMS
||     |  ..  |   . .   .... |.. ||.   |..   |..     ..|   .  .. .|         ..|.  . .| ....     |   
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhc

MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHR
  | ||.||..|. ...  ... ||.. ||.. .||  | |.|   ||.  |..
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk

subfamily_CG7180_pd Subfamily CG7180 132-373 2.8e-13 44.2 In-house 24-286 (296) alignment
Range on Protein: 132-373
Range on HMM: 24-286/296.0
KQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLT--NGP--ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL
|.| ....    .   |.|. | | ...  .. . | |.  .|   . .| |. .     ..  | |. |  ..   . .|||....| | .||.   . 
kltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkket...vdefWrlvydeeisavvvLtktf

EVTL--QQILPLLSgtYSTYGKMFVNNKKVESAVGMTEYCLEIFPD----------GCSNSLLTTVYHLHNWRQKRGLEVV-TDLVATMEKVMKVNDNT-
. .   .. .|  |     ||..||.  ....   .. . . .                .  . ....|  |  .  . .. . |.  ...| .. ... 
dfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

--------VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
        | .| .|..|.|  |..  .. .|.| .||.  | .  || .| ..|.|....  .   .
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl

subfamily_PTPN23_pd Subfamily PTPN23 133-371 3.6e-14 47.3 In-house 26-274 (288) alignment
Range on Protein: 133-371
Range on HMM: 26-274/288.0
QTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKIT-VPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTL
|... ..   |.   | . .| |  |.   ... ||| .. . .| |. .  .     ..| || |  |.   ..|||.|....    .|. . . |   
qkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst...lnDFWlmvyeqkssviVmllskeelgk

Q---QILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKrGLEV-VTDLVATMEKVMK--------VNDNTVLMSMN
.   .  |   |   ..|.. |  |.|...  . |. |..   . ..    .  .|..| .  |.     .|.. ...| .        ..   |.    
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpel.GvPasPetllqfldevesayeavqrksktPlvvhCsa

GTGRAGTMLTLFTAMLQVQKGKEV-NAKETLASLRAERCGIVDNIDQFGTVHR
| ||.|..  ...|. ...||. . .  . .  ||..|   | . .|.  .  
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsye

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 137-381 3.7e-09 30.6 In-house 39-294 (310) alignment
Range on Protein: 137-381
Range on HMM: 39-294/310.0
FKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTN---GPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEVTLQQ
 . .  .  ..|..||| |  |    ..  |||.      | .| |  .    .  |.| .| |       | |||||| ||   |... .   |    .
kqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqh...tiidfwrmifqeraesilllckvgeegrpk

---ILPLLsGTYSTYGKMFVNNKKVES-AVGMTEYCLEIFPDGCS-----NSLLTTVYHLHNWRQKRGLEVVTDLVATMEK--VMKVN-DNTVLMSMNGT
     | | |   ||| . | |    |    . . .. . ||          |      | .| .     |  . . |. .  . .|     |.    | 
cvgywpsl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagk

GRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
.| .....|  .. ....|..|.|.|  . |. .|   ...  |.  ..| .  . . ..
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarget

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 138-373 3.4e-14 47.5 In-house 31-267 (288) alignment
Range on Protein: 138-373
Range on HMM: 31-267/288.0
KTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQ---I
....|.  || .|  . |  . |  .   |||.. |. .| |  ..   ..| .| .| |       |  .|.|. .. .  .|.    ||  ...    
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaey

LPLLSGTYSTYGKMFVNNKKVESAVGMT-E-YCLEIFPDGcSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFT
.|.  |    .|..    ||  . .  . .   | |   |  .. .  . ||..| ..   |     .  .| . ...   |..| .|.||.||.   . 
fPsklGekarigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlilili

AMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
|. ...    .  .. ||.||.||   .    |.  ||| .
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcv

0045450 (Phosphotyrosine protein) phosphatases II 141-379 2.4e-43 144.4 In-house 46-306 (307) alignment
Range on Protein: 141-379
Range on HMM: 46-306/307.0
MDSCPSFKNNMHKIRAPDCPIPEEKLVKLTN-----GPESFICAAKI--------TVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
  |. ....|..| | .|... .   |||..     .. ..| |  .         ..|..|..|.||.|  .    ..|||||.... .  .|    . 
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...tvedFwrmlweqgvtvivmltelv

EVTLQ---QILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMS
| . .   |  |.  |.. |||...|.....|   |.| ..||. .  |...|.  |..| ..|      . . .|.. .|.|.|       .  .. ..
elgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC

MNGTGRAGTMLTLFTAMLQVQKGKE---VNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
. | ||.||........ |..|...   |.. |... ||. |.|.| | .|.  ... .. ....
saGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 141-379 5.1e-14 47.0 In-house 42-282 (318) alignment
Range on Protein: 141-379
Range on HMM: 42-282/318.0
MDSCPSFKNNMHKIRAPDCPipEEKLVKLTNGPES-FICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS
....  .||    | | |      || .|.. ..| .| |  |     ... | .| |    .  | |||||. .   | .|.     | . ...     
lepvnkaknryanilaydht..rvkLqmlegeegsDyinanyidGyrrkkayiaaqaP...lpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

-GTYSTYGKMFVNNKKvesAVGMTEYCLE---IFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN-----DNTVLMSMNGTGRAGTMLTL
     .|||. |. |.    | ...| |    .  .....|     ||  .| ..  .| ...|.. . .| |..     . .|     | ||.|. ...
skgsrsygklvvelke...evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiav

FTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
 . . .... . |.  .|   || .|  .|   ||.  ..  .    . 
dillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 142-378 2.7e-10 34.8 In-house 33-278 (307) alignment
Range on Protein: 142-378
Range on HMM: 33-278/307.0
DSCPSFKNNMHKIRAPDCPIPEEK-LVKLTNGP-ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
 .  .|. | .| |  | .  .   .|  ..|    .| |  . .    . .| .| |  ..   . .|| |. || . ||.. .  .|   .  .|  |
vtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplent...qysfwamaiqekvesvimlckvielakikceqywp

LLSGTYSTYGK----MFVNNKKVESaVGMTEYCLEIFP---DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVmKVNDNTVLM-SMNGTGRAGTML
|  |   ..|.    . |.|  ..  .   | ....     | ...|   . .  .|| ..   ..    .  .| | . . | |..    | ||.||..
leegqklvfgeapntisvanlgakk.lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav.rydtnpvvvhcsaGvGrsGtiv

TLFTAMLQVQKGKEVNA-KETLASLRAERCGIVDNIDQFGTVHRSMACWFK
..   . .. .|..  . |. .  ||..|   . .  |.  .|| .  .| 
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl

0046845 (Phosphotyrosine protein) phosphatases II 143-382 5.5e-42 139.5 In-house 21-279 (284) alignment
Range on Protein: 143-382
Range on HMM: 21-279/284.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTN-----GPESFICAAKITVP-----DFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEV---
|.  ...|..| | .|... .   |||..     .  ..| |  ....     ......|.|| |  .    ..|||||.... .  .|    . |    
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelvengre

TLQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV------NDNTVLMSMNGTG
   |  ||  |.. |||...|.....|   ..| . ||. . | ...|.  |..| ..|      . ..||.. ...| ..      .  .| ....| |
kcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RAGTMLTLFTAMLQVQKGK---EVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
|.||...| ... |..|..   .|.. |... ||  |.| | . .|.  |.. .. ..|.  |
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0040439 (Phosphotyrosine protein) phosphatases II 143-379 9.5e-42 138.7 In-house 4-248 (249) alignment
Range on Protein: 143-379
Range on HMM: 4-248/249.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTN----GPESFICAAKITVPDFNRTMILTQVPdLSSapDIADFWRMIHQESIASVVIAVMPLEV---TLQQIL
|. ....|..| | ||.....   |||.      . ..|.|  |......|..|.|| | |..   ..|||||.... | ..| .  . |    . .|. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP.lpe..tvedfwrmlwelgitvivmLtslvelgrekcaqyw

PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMSMNGTGRAGTMLT
||  |.. .||...|....||.  ..| . ||. . ....|.  .... ..|      . . ||.. .|.|.|       .  .. ....| ||.||...
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
..... |..| ..|...|... ||  |.|.| | .|.  ... .. ....
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk

0042113 (Phosphotyrosine protein) phosphatases II 143-378 7e-39 129.1 In-house 2-244 (245) alignment
Range on Protein: 143-378
Range on HMM: 2-244/245.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPES----FICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLE---VTLQQIL
|. ....|..| | .|... .  .|||.. ...    .| |  ..........|.|| |  .   ...|||||.... | ..|    . |   |. .|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqyw

PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLE---VVTDLVATMEKVMK--VNDNTVLMSMNGTGRAGTMLTL
||  |.. |||...|.....|.  ..| . ||. ..|.. |.  ..|| ..|      .    . |..  ..|...   |  .. ... | ||.||....
pl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

FTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.... |..| ..|.. |... ||  |.|.| . .|.  ... .. ..|
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

0037934 (Phosphotyrosine protein) phosphatases II 143-377 1.8e-36 121.3 In-house 3-242 (243) alignment
Range on Protein: 143-377
Range on HMM: 3-242/243.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLtNGpESFICAAKITVPDfnrTMILTQVPDLSSAPD-IADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGT
|......|..| | .|..  .   ||| .| ...|.|  |.|..   ..|.||.|  ..  |  |.||||.... | ..|    . | . ..  .. .|.
siallpenlsknrysdilpydhsrvkl.eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

YsTYGKMFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN------------TVLMSMNGTGRAGTML
. |||...|.....|.  ..| . |.. . .    ..| . || ..|      . ..||.. ...| .. ..            .... . | ||.||..
v.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

TLFTAMLQVqkgkEVNAKETLASLRAERCG-IVDNIDQFGTVHRSMACWF
.... .|..    .|.. |... ||. |.| .| . .|.  ... .....
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPN14_pd Subfamily PTPN14 143-379 1e-08 29.5 In-house 42-298 (300) alignment
Range on Protein: 143-379
Range on HMM: 42-298/300.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLT---NGPESFICAAKI--TVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQI
|. . ..| .| | .|    |.  |.|.   .  . .| |..|  .|   .|. | .| |       . |||.|. .. .. .|.     |       . 
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

LPLL--SGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPdgCSNSLLTTVYHL--HNWRQKRGLEVVTDLVATMEKVMKVNDN-------------TVLMS
.| |  .    ..||  | .| .|..  ..  .|..       .   ||.||   .| ...  | |.. .  .|.|  |  .              ..  
fPkleskkktvefgkfkvttkfsedsdsvittglklkh..lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
 .| ||.| ...    .  .....|.. |..|| ||  |  .|... |.  |.. .  ..||
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

DSPc_SM00195 144-377 6.4e-44 145.6 In-house 20-262 (263) alignment
Range on Protein: 144-377
Range on HMM: 20-262/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
.  .|.|..| |  .... ... |||.. .    ...|.|  |.... ....|.|| |       ..|||||. .| .  .|. ... |    . ..  |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp

LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLF
  ||...|.||. |....||.    .. . ||.  .|....  .|.|. .|| ..   .  ..... ...| |     .  .| .. .| ||.||..|. 
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .....|.|. .|.. .|| .|.|.|.. .|. .... .. ..
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 144-377 6.4e-44 145.6 In-house 20-262 (263) alignment
Range on Protein: 144-377
Range on HMM: 20-262/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
.  .|.|..| |  .... ... |||.. .    ...|.|  |.... ....|.|| |       ..|||||. .| .  .|. ... |    . ..  |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp

LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLF
  ||...|.||. |....||.    .. . ||.  .|....  .|.|. .|| ..   .  ..... ...| |     .  .| .. .| ||.||..|. 
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .....|.|. .|.. .|| .|.|.|.. .|. .... .. ..
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 144-372 1e-12 42.5 In-house 27-261 (283) alignment
Range on Protein: 144-372
Range on HMM: 27-261/283.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVP---DFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVM---PLEVTLQQILPL
. | ..| .| |  .    . . |.| . ....| |. |.|    . ..  | .| | |  .  . |||.|...| |...|.       |..   |  | 
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsP.ldrt..vvdfWkmvfdekitaivmltklqedlrikCsqyWPk

lSGTySTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVAtMEKVM----KV-NDNTVLMSMNGTGRAGTMLTLF
  |.   ||.. |  .|  .   ..   | .  .  . ..|| . | . .| .     ..  ||  ..||.    .  .   |.   .| ||....... 
.rGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfiaas

TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
... ...    |.  ...  .| .| ..| . ||.  ||  
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhel

0045098 (Phosphotyrosine protein) phosphatases II 146-379 1.9e-22 75.4 In-house 29-274 (278) alignment
Range on Protein: 146-379
Range on HMM: 29-274/278.0
SFKNNMHKIRAPDCPIPEEKLVKltngpeSFICAAKITVPdfNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPllSGTY
 . .|..| | .| .  .   ||       .| |  |...  ....|.|| |       .||||||.... | ..| .   .| .     |  |  .| .
lylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggs

STYGKMFVNNKKVESAVGMTEYCLEIFPD----GCSNSLLTTVYHLHNWRQKRGLEVV-----TDLVATMEKVMK--------------VNDNTVLMSMN
 |||...|.....|    .|   |..           |.  |..|...|      .        .|.  .....|               .  ..   . 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GTGRAGTMLTLFTAMLQVqkGKEVNAKETLASLRAERCG-IVDNIDQFGTVHRSMACWFKN
| ||.||.  ... . ..  .. |.. |... ||  |.| .| | .|.  ... .. ....
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 146-374 3e-14 47.7 In-house 50-276 (315) alignment
Range on Protein: 146-374
Range on HMM: 50-276/315.0
SFKNNMHKIRAPDCPIPEEKLVKLTNGpESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTY
  ||  ..| | |   ..  |..  ..   .. |. |   . .|  | .| |  .|   . ||||....| |. .|.     |   ..          .|
kqknryiniiaydksrvqlpllendph.sdyvnanfidGynkkrryiaaqgpnvas...vkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy

GKMFVNNKKVESavgMTEYCLEIFpDGCSNSLLTTVYHLH--NWRQKRGLEVVTDLVATMEKVMKVNDNTV----LMSMNGTGRAGTMLTLFTAMLQVQK
||. |  |. |     |||.   .    ... . .|. ||   | .    .  . |.  . .|.. ..|.|    .   .| ||.||..|| . . |.. 
Gkitvtrkseev...nteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea

GKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMA
 . ..  . .  .|. | ..|. ..|.  ..  . 
enaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 146-376 2e-13 45.0 In-house 31-258 (267) alignment
Range on Protein: 146-376
Range on HMM: 31-258/267.0
SFKNNMHKIRApDCPIpEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTY
.  ......    .|  ... | | .  | .| |. .     ....|.|| | |. .  |.||. .||.. .. .|.  .  .  .... |   |    |
eknqernrldd.nlpy.ddtrvilrtkeeeyinasyvegyktknafivtqdp.lknt..itdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakky

GKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLlTTVYHLHNWR----QKRGLEVVTDLVATmEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGK
  . |.    .         ||.     |     |.|. ..|     .|  |. .  ..|  ... . |   |.   .| ||.||.|.. . . ....  
qdltvehslekeendyqiitlelkfknesahn.vtlyyykkwnintnnkpylkplfgilak.nqlengnrPlvvacsdGvGrsGtflvidsqlerakteg

EVNAKETLASLRAERCGIVDNIDQFGTVHRSMACW
 ..  . |  .|  | |.||  ...  .|...| .
vsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 146-377 4.4e-09 30.7 In-house 31-270 (285) alignment
Range on Protein: 146-377
Range on HMM: 31-270/285.0
SFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNR-TMILTQVPdLSSapDIADFWRMIHQESIASVVIAVMPLEVTLQQI---LPLLSGT
... |    |  |    ||  | | |    .| |. . .|  .. | | || | |     ..|||.||.|| || |.. .  .|  ...     |   | 
ayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgp.lpe..tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

YSTYGKMFV--NNKKVESAVGMTEYCLEIF--PDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTV---LMSMNGTGRAGTMLTLFTAM
   .||  .   . | |.  |    .| .    | .|. |     ..  | ..   |    ..   . | ||| .     .    | ||. |.. .  | 
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat

LQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .  ...  . .  .|| |   |..  ||  ..  .  .|
irimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Ptp69D_pd Subfamily Ptp69D 148-387 7.8e-18 59.6 In-house 46-296 (307) alignment
Range on Protein: 148-387
Range on HMM: 46-296/307.0
KNNMHKIRAPDCPIPEEKLVKLTN--G--PESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS-GTY
|.|  | | .|    ... |||..  |    ..| |  |   . ... |  | |       | |||||| . ..  .|.     | . ...    .  . 
kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv...eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiede

STYGKMFVNNKKVESAVGMTEYCLEIFPDG-CS----NSLLTTVYHLHNWRQKRGLEVVTDLVATMEKV---MKVNDNT-VLMSMNGTGRAGTMLTLFTA
  ||.. |.  . |..   ..  |..   . .|    .|   . ||  .|.     || . |.  .|.|    | |    |.   .|.||.|....|   
vqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsl

MLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQ
. |... ..|.  ||   || .|  .|....|.  ..|... . .   |.|.|.
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 148-381 1.6e-17 58.5 In-house 45-283 (288) alignment
Range on Protein: 148-381
Range on HMM: 45-283/288.0
KNNMHKIRAPDCPIPEEKLVKLTNGPE----SFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL---EVTLQQILPLlSG
 .| .| | ..    .|| |||....|     .| |. | . . ... | || |  ..   . |||...... .  .|     .   . . ..  |  ..
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt...vndfWelvyenktstivmltelveggktkCeeYWPd.ad

TYSTYGKMFVNNKKVESAVGMTEYCLEIFpdGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNT----VLMSMNGTGRAGTMLTLFTAMLQ
.   ||.. |  ....    ...  |..      . | .| |.   | ..   |  ..|.. ...|   |..     .   ..| ||.|| ..| ... .
kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalida

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
|.. . ..  .|.| || .|  .|..  |.  ... ..   ....
veeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg

subfamily_PTPRK_pd Subfamily PTPRK 148-372 4.5e-14 47.0 In-house 41-272 (314) alignment
Range on Protein: 148-372
Range on HMM: 41-272/314.0
KNNMHKIRAPDCPIPEEKLVKLTN--GP--ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYS
..| .| |  |   ..  .|.|.   |     .| || |      .  | || |  .    ..||||....|  ||.|.     ||.  . |       .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet...vkdfWrlvydencasivmltelvevgrvkClkyWPedte

TYGKMFVNNKKVESAVGMTE--YCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND----NTVLMSMNGTGRAGTMLTLFTAMLQV
.||.. |.  ..|    .    . .|    | ..  .   ..  .| .       | |.. . .| | ..    ..|.  ..|.||.|| ... . .  .
vygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi

QKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.. . |.  ..  .||...  .|.  .|.  ..  
eregvvdvfnavktlrsrkvnmveteeqykfiydv

subfamily_PTPN3_pd Subfamily PTPN3 148-371 9.4e-11 36.1 In-house 39-269 (280) alignment
Range on Protein: 148-371
Range on HMM: 39-269/280.0
KNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKIT--VPD--FNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLlSG
 .|..| |  |    ..  |||....  .| |  .   .|   .    | || |  ..    .|||.|......  .|.    .|       |  |  ..
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlakt...atdfWqmvweqksslivmlttlverGrvkChqyWPe.te

TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
  ..||.. |. .| ..   .    | .     ...   .     .| ..   .  .|..  .|.| |.     . .|.    | ||.| ...| ||.  
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHR
... ..|.  . .  .|  |  .|.. .|.  |  
ieaaepvypldivrtmrdqramlvqtasqykfvCe

subfamily_egg_pd Subfamily egg 148-379 1.2e-07 25.7 In-house 38-272 (307) alignment
Range on Protein: 148-379
Range on HMM: 38-272/307.0
KNNMHKIRAPDCPIPEEKLVKL--TNGP--ESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL-QQILPLLSGTY
.||..| |..  .  .   |||   .|   . || | ..    .  ..||.| | |  .    |||||..|| .  .|.     |    .   |      
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqap.lknt..vddfwrmvfqeevqyivmltsrkeserceyywpkaesds

STY--GKMFVNNKKVESAVG----MTEYCLeIFPDgcsnsllTTVYHLHNWRQK-RGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAML
  .  | . ..| ||.|.      .|.  | . .|           .|  |.   . .  |   .  . |. ..   .|. ...|  .|.|.... .|.|
lvtvpGslrienlkvdskadplfrvtklkl.vGgd.......deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiall

QVQKGKEV--NAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
.. .|  .    ...   || .|   |. . ..  |.| .. .|..
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 149-375 1e-11 39.3 In-house 46-276 (287) alignment
Range on Protein: 149-375
Range on HMM: 46-276/287.0
NNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTY-STYGK
.| .| |  .  .|... | | .  . .| |. |     ..  |... |  . |    .||..|... .  .|. .   | . ..     . .   ..|.
qnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfnta...rnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe

MFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND-----NTVLMSMNGTGRAGTMLTLFTAMLQVQKGK
  ..  . |   |..|  ||.  ..  .. .  . |.. || ... ..     .  .|. .| .        |    .. ||.....   |.. ....  
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG

EVNAKETLASLRAERCGIVDNIDQFGTVHRSMAC
 ..  . | | |  . | |  ..|.  .   .  
viDvfqvlksqriqkpgsvqtveqykfindivle

Y_phosphatase Protein-tyrosine phosphatase 150-373 2.3e-40 133.9 Pfam-A 1-233 (235) alignment
Range on Protein: 150-373
Range on HMM: 1-233/235.0
NMHKIRAPDCPIPEEKLVKL--TNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... |||  ..||. .| |  ..  . ....|.|| |  |.    .|||||. || . ..|. .   |   ....|  |  .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKMFVNNKkVESAV---GMTEYCLEIFPDGCSN-SLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
||...|..| ...     ..| . ||.  .. .. .  ....|..|| ..   | ...|. ...|| | .     ..| ....|.||.||...| ... |
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
.....||. .... .||..|.|.|....|.  ... .
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 150-373 2.3e-40 133.9 In-house 1-233 (235) alignment
Range on Protein: 150-373
Range on HMM: 1-233/235.0
NMHKIRAPDCPIPEEKLVKL--TNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... |||  ..||. .| |  ..  . ....|.|| |  |.    .|||||. || . ..|. .   |   ....|  |  .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKMFVNNKkVESAV---GMTEYCLEIFPDGCSN-SLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
||...|..| ...     ..| . ||.  .. .. .  ....|..|| ..   | ...|. ...|| | .     ..| ....|.||.||...| ... |
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
.....||. .... .||..|.|.|....|.  ... .
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai

0041856 (Phosphotyrosine protein) phosphatases II 150-382 4.2e-14 48.0 In-house 1-176 (182) alignment
Range on Protein: 150-382
Range on HMM: 1-176/182.0
NMHKIRAPDCPIPEEKLvkltngPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVmplevtL----Qqilpllsgtysty
|..| | .| . ..  .      . ..| |  .  .  ....|.||.| ||   ..|||.||.... | ..| .                          
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt......eelywp.............

gkmfvnnkkvesavgmteycleifpdgcsN--SLLTTVYHLHNWRQKRGLEvVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkEV
                             .    | . |. ..|      . . .|.. .|.| . . ...   . | ||.||.  ..  . .     .|
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

NAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
.. |... .|  |.|.| . .|.  ... . ...... |
sleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 150-361 1.4e-10 35.3 In-house 54-267 (290) alignment
Range on Protein: 150-361
Range on HMM: 54-267/290.0
N--MHKIRAPDCPIPEEKLVKLTNGPES-FICAAKitVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYS
|  ..| |  | .  .   | | .| .  .. |    |   . ..|||| .    .  . |.|||. || .| .|.    .|      .|  |  .|   
ntefkknrykdvvcndktrvilkdGydGdyvhany..vkGlkamfiltqGal...kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

TYGKMFVNNKKV-ESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKE
|.|.. |   .  .    .    | .       .     ...  | .|        |. |.  . |..   |.    | ||.||. .. ...  . .|||
tfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGke

VNAKETLASLRAERCGIVD
..  ..  .||  | . |.
ldlldlvralrnsrlnsvq

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 151-372 2.8e-11 37.8 In-house 47-278 (290) alignment
Range on Protein: 151-372
Range on HMM: 47-278/290.0
MHKIRAPDCPIPEEKLVKLT------NGPESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL---EVTLQQILPLLsGT
 .. |  .. ..... . |       . ....| |. |     ..  |.|| |  .    ..|||..| ||... .|. .      .|. ||  |   .|
kllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt...lvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dt

YStYGKMFVNNKKVESAVGMTEYCLEIFPDGC-SNSLLTTVYHLHNWRQKRGLEVVT---DLVATMEKVMK--VNDNTVLMSMNGTGRAGTMLTLFTAML
 . ||.. ..  . |.  ...|  ||.  .    ..   | |.. || ..  ..  .    ... |.| ..   |   |.   .. ||... ... |.. 
ka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

QVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
....   ..  . | |.|  . | |   .|. .... 
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqi

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 152-365 6.5e-08 26.7 In-house 52-269 (301) alignment
Range on Protein: 152-365
Range on HMM: 52-269/301.0
HKIRAPDCPIPEEKLV-KLTNGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYSTYGK
.| | |  |   .  |  ...|    | |  |  .   . .| || | |...    ||| |. |  .  .|.    .|      .. ||.  .     |.
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgP.lknt..sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

MFVNNKKVESAVGMTEYCLEIFPDGCSNSL-LTTV--YHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVN
  .. |. |. .    .  ..     .. .   ||  |  ..| ..   .  ..|   || | | ..  |.   .| ||. ....      .|.  ....
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptie

AKETLASLRAERCGIVDNIDQ
 .|.|. || .|   | .  |
ltealkhlrehrwngvqtnsq

subfamily_PTPRB_pd Subfamily PTPRB 165-381 1.5e-10 35.6 In-house 69-289 (293) alignment
Range on Protein: 165-381
Range on HMM: 69-289/293.0
KLVKLTNGPE-SFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLSgTYSTYGKMFVNNKKVESAVG
|| .|.. ..  .| |  |     .|  | || | | ..  . |||||....    .|.    .|      ..  |  . .  .||.. |. .. |.   
kLaalkdesgsDYinanyipgynsprefiatqGP.lpet..vddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeled

MTEYCLEIFPdgCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN------DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
 .   |.|     ...  .. ||   | .    |  . |.. ...| ..         .|     | ||.|| ..| . . ....   |.   ..|.|| 
wvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelRe

ERCGIVDNIDQFGTVHRSMACWFKNNS
||. .| . .|.  .|...   .....
eRnllvqtekqYifihqcvldllrkke

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 167-370 1e-14 49.2 In-house 61-270 (315) alignment
Range on Protein: 167-370
Range on HMM: 61-270/315.0
VKL---TNGPE-SFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYSTYGKMFVNNKKVESAV
|||    . |.  .| |..|   | ... | .| |  .|   . |||||. || ....|.     |   .  .|  |   .    .|.. |.  ..|.  
vkleviddsPdsdyinasyiksvdddkayiasqgPlkas...vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadt

GMTEYCLeIFPDGcSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN---DNT-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAE
...   | .  ..  .|   | .....| .|   . .. |.  . .|   |   . . ..  . |.||.| ....   . |..... |.  ...  |||.
dgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrak

RCGIVDNIDQFGTVH
|  .|   ...  ..
rpylvqteeeyafiy

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 167-370 3.4e-13 43.5 In-house 60-269 (515) alignment
Range on Protein: 167-370
Range on HMM: 60-269/515.0
VKL---TNGPES-FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYSTYGKMFVNNKKVESAV
|||    . |.| .. |..|   | ... | .| |  .|   . ||||.. || .. ...     |       .  |   |    .|.. |.   .|.  
vklevindnPhsdyfnasyipsfdndkayiasqgPnkas...vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleact

GMTEYCLEIFPDgcSNSLLTTVYHLHNWRQKrGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
|..   |..  .  ..|   | .|...| .| | .  |  .  . | .| . .      ..  . | ||.| ....   . ...... |.  ...  .|.
ggikrkltvlkg..ddsrtvtqfhfteWPdk.GvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirq

ERCGIVDNIDQFGTVH
.|  .|   .|.  ..
krpylvqtqeqyafiy

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 167-371 2.2e-09 31.9 In-house 27-234 (239) alignment
Range on Protein: 167-371
Range on HMM: 27-234/239.0
VKLTNGPES-FICAAKITVPDF-NRTMILTQVpdlSSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEY
 ||.| | | .| |. .   |   .. | ||    . ...  |||||. ||  . .|.    .|   ..       . | | .. |  .| |        
eklsndphsdyinasylrdydgspkayiatqg...cveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir

CLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
 . .   | ..      ||.  | .|   .  | ..    |. | .       |.    | ||.|..| . . . | .| | |.  . . ..| .|  .|
tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

DNIDQFGTVHR
.  .|.  .| 
qtseqyvfihl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 167-371 2.4e-09 31.7 In-house 28-235 (239) alignment
Range on Protein: 167-371
Range on HMM: 28-235/239.0
VKLTNGPES-FICAAKITVPDF-NRTMILTQVpdlSSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEY
 ||.| | | .| |. .   |   .. | ||    . ...  |||||. ||  . .|.    .|   ..       . | | .. |  .| |        
eklsndphsdyinasylrdydgspkayiatqg...cveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir

CLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
 . .   | ..      ||.  | .|   .  | ..    |. | .       |.    | ||.|..| . . . | .| | |.  . . ..| .|  .|
tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

DNIDQFGTVHR
.  .|.  .| 
qtseqyvfihl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 168-373 9.1e-16 52.9 In-house 64-279 (305) alignment
Range on Protein: 168-373
Range on HMM: 64-279/305.0
KLT----NGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVM---PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVG
.||    .. . .| |. .   . . . |..| | | .   .|||||.| .| . ..|. .      .   .|  |   .    .|.. |. |  ..| .
iltekeslddsdyinasyvdgykrkkkyivaqgP.lknt..vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasd

MTEYCLEIFP-DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNT-----VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
 .|  |.|   |. ..|   . |.| .| ..   .  | |.  ...|.|   .      .    .| ||.|. ...  |. ...| ..|.  | |  || 
yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRs

ERCGIVDNIDQFGTVHRSM
.| ..| . ||.  .|  .
krmkmvqtldqYvflhdal

subfamily_PTPN12_pd Subfamily PTPN12 168-382 6.7e-15 49.7 In-house 61-282 (290) alignment
Range on Protein: 168-382
Range on HMM: 61-282/290.0
KLTNG-PESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAV-GMT
| ..   ...| |  |  .. . . | .| | |. .  . |||||| . ..  ||.| . .|.     ..  |   ..  ..|.. |.... .    ...
kieeeegsdYinanfikgvegkleyiaaqgP.Lpkt..lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddfl

EYCLEIFPDGCSNSLltTVYHLHNWRQK---RGLEVVTDLVATMEKVMKVNDNTVLM-SMNGTGRAGTMLTLFT--AMLQVQKG-KEVNAKETLASLRAE
  .|..  .. |...  . .| ..|  .   .. . . .|....... . .|. ...    | ||.||....     .|. .|  .|..  . ...|| .
irtLkveaqkesrkv..yqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkq

RCGIVDNIDQFGTVHRSMACWFKNNST
|  .|   .|.  |....|  .... .
raalvqtkeqyelvykavaelvqkele

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 171-378 3.6e-15 50.9 In-house 75-285 (297) alignment
Range on Protein: 171-378
Range on HMM: 75-285/297.0
NGPES-FICAAKitVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIF
. |.| .. |.   |. ..  .| || |  ..   .||||.|. .| .. .|.     | . .        . .|.|.. |  . |..  |. .  ||. 
ddpdsDyvnasf..vkgnkhrlittqmPmkat...vadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevt

PDGCSNSLLTTVYHLHNWRQKR-----GLEVVTDLVATMEKVMKVNDN--TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDN
 .   .  .   |.  .| .|        . . .|.  ..|. . | .   ..  ..| ||.| .||.   . .... |||.  ...  || ||  .|  
kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt

IDQFGTVHRSMACWFK
 .|.  |.  .   . 
keqykfvyvavleall

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 171-339 1.2e-09 32.3 In-house 63-229 (281) alignment
Range on Protein: 171-339
Range on HMM: 63-229/281.0
NGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLEVTLQQ---ILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLE
.    .| |  |  | ..|  |||| |   .    ||||||| ||  ...|. .  ||   ..    .|  .     . |. |. .       .    |.
knstdyihanyirspflkrgyiltqgpkketr...adfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrln

IFPDGcsNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQK
.  .|  .. | | .  ..| . .  |    ..  . |.       |.    | ||.||....  |.  .. 
lsyeg..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihs

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 174-374 2.1e-17 58.3 In-house 84-287 (298) alignment
Range on Protein: 174-374
Range on HMM: 84-287/298.0
ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFP
  .| |. .   . . . |.|| |  ..   ..|||||. .| |...|.     |.   . ..  |  .    |||.. |. .. |.   ..   |..  
sdYiNAsflhaykgrnafiatqaPltet...vedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvsk

DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN----T-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
   ...      |  .| .|   |. | ... ..|| . . .      ..   .|.||.||   . . . .|.| . |   ...  ||..|.|.|.  .|
kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq

FGTVHRSMA
.  ..  . 
Yvfiyeavl

subfamily_PTPRN_pd Subfamily PTPRN 174-373 8.4e-09 29.5 In-house 84-288 (297) alignment
Range on Protein: 174-373
Range on HMM: 84-288/297.0
ESFICAAKITVPDFNR-TMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNnKKVESAVGMTEYCLEIFPD-
. .| |. |.  |  . . | || |    |  .||||.|. .. .. .|      |  ..|       . |   ...   . |   .   .| .  |   
sdyinasaildhdprapayiatqgp...lastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyev.hlvsehiwcddylvrsfylk

G--CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNID
    |..   | .|   |...        |.    || |         |. ...|.||.|. . .   . ...|| ||..   ||  || .| |.|   |
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd

QFGTVHRSM
||  .  ..
qfefaltav

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 175-379 1.4e-14 48.9 In-house 58-270 (274) alignment
Range on Protein: 175-379
Range on HMM: 58-270/274.0
SFICAAKITVPDFN-RTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL---QQILPLLSGT--YSTYGKMFVNNKKVesaVGMTEYCLEI
|.| |  |  .| . .. . || | |...  .|||||||.||..  .|.     |      ..  |   ..    .||.. ....|.   |   .| .. 
syinanyikGydeeskayvatqGP.lpnt..vadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki...verndysvrk

FPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-------TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
.    ....   . |   .|  ..  . .. |. ....| . ...       .|.    | ||.|  ..   |. |... . |.  .. . || .| |.|
lvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv

DNIDQFGTVHRSMACWFKN
.. .|.  .|| .. . |.
qtseqyelihralclylkr

0043147 (Phosphotyrosine protein) phosphatases II 175-370 4e-09 31.9 In-house 6-154 (172) alignment
Range on Protein: 175-370
Range on HMM: 6-154/172.0
SFICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVmPLevtlqqilpllsgtystygkmfvnnkkvesavgmteycleiF-----
 .| |  . ..   .  | || |      ..||||||.... |  .| .  .|                                         .     
dyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnlt.el.........................................lydpel

-------------PDGCSNsLLTTVYHLHNWRQK--R--GlevvtdlvatmekvmkvNDNTVLMSMNGTGRAGTMLTLFTAMlqvqkgKEVNAKETLASL
             ||..   ||  .... .. ..                       .  ..   . | ||.||.  ..  .      . ... |..| .
lerlgiqylylpwpDhgvp.llellleflefidellalsp.................ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

RAERCGIVDNIDQFGTVH
|. |.|.| | .|   ..
rekRpgavqnpsqyrfly

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 175-368 3.8e-07 24.5 In-house 47-250 (290) alignment
Range on Protein: 175-368
Range on HMM: 47-250/290.0
SFICAAKITVPDfNRTMILTQVPDLSS----APDIADFWRMIHQESIASVVIAVMPLEVTLQ-------QILPLLSGTYSTYGKMFVNNKKVESAVGMTE
 .| | ..|.|. .  .|||| |        .  | .|| |..|| . .||      | . .       .  |   |.  ... . |. |. |   .. .
dyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

YCLEIFPDGCSNsLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQ-KGKEVNAKETLASLRAERCGIVDN
  |..  |.  . .  | . |..| .    |    |.. ..||.. .   ..  ..|  |  .. ..  ..  .  . ..|. .. | .|| .|   . .
Relvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaits

IDQFGT
  ... 
alelaf

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 176-372 2.2e-17 58.1 In-house 39-237 (250) alignment
Range on Protein: 176-372
Range on HMM: 39-237/250.0
FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAV--MPLEVTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGC
.| |. . . | ... | || |  ..   | |||||. .| ....|.       | | .| .|    .  .||.. |. .. |    .|   | .     
yinasflhgyderkafiatqgPlqat...iedfWrmvleeksgtivmLtnLkesektyhqywPv..ekaekyGdvtvsllskeefadytkrklklskakk

SNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
... .   .|  .|  |   || |  .. ..|| . ...      ..   .|.||.|. ... . . ...| | |.  . .  ||..| . |.  .|.  
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf

VHRS
|.. 
vyei

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 176-388 1.1e-16 55.8 In-house 78-294 (319) alignment
Range on Protein: 176-388
Range on HMM: 78-294/319.0
FICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIA---VMPLEVTLQQILPllSGTYSTYGKMFV--NNKKVESAVGMTEYCLEIFP
.| |. |   . ..  | || |    .  | |||||. .| .  ||.    | .|.| |... |  . .. .||.. |  ....  . . . . .|..  
yinasfidgyqerekfiatqaP...lentiedfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkks

DGCSNsLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
.        . ..  .| ..   |  | |.. .... |  ..      |    .| || || ..|. .. .|..   ..  .|   ||. |  .|.. .|
sevet.RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq

FGTVHRSMACWFKNNSTNEEVQR
.  ..  .  . .  .|. ||| 
Ykfiyealleaveagdteievqd

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 176-383 2e-14 48.5 In-house 78-294 (325) alignment
Range on Protein: 176-383
Range on HMM: 78-294/325.0
FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESiASVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG
.| |. .       ... .|.|  ..   | |.||.. .   .|||. .  |.       .  |   |   |.| . |. . .|         |..    
yinasylrddkkkdvflaaqaPltat...indlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk

CSNSLLTTVYHLHNWR----QKR--GLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDN
  ...    ..|  |     |||   |  ...|| .... .. |       ..  ..| ||.|....|..|. .| .  .|.  . .  ||..|  .|. 
kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvet

IDQFGTVHRSMACWFKNNSTN
.||.  .. ...  . .  |.
vdqyiliyealveaymsgntd

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 176-374 5.7e-13 44.0 In-house 55-252 (284) alignment
Range on Protein: 176-374
Range on HMM: 55-252/284.0
FICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSN
.| |. ||    .   | || |       .||||||| .  ....|.     .    |  ||   .  ..... |. . || .  ..   .|.  ||  .
yinasfitGyqrkdkyiatqGPl...dntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveeseeyvvrdielsedgkek

SL-LTTVYHLHNWRQKRGLEVVTDLVATMEKV------MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
     . .|.  | ..   .  .||.. ..||      .. . | |.    |.||.|....| . . .... | |.  ...  || .|  .|... |.  
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf

VHRSMA
.. .. 
iysall

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 176-373 1.3e-12 42.7 In-house 91-287 (319) alignment
Range on Protein: 176-373
Range on HMM: 91-287/319.0
FICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSN
.| |. .|    .   | .| |       .||||||| .  ....|.     .    |  ||   .  ..... |. . || .   .   .|.  ||  .
yinasfvtGyqrkdkyiaaqGPl...dntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveetaeyvvrdielsedgkek

SL-LTTVYHLHNWRQKRGLEVVTDLVATMEKV------MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
     | .|.  | ..   .  .||.  ..||      .. . | |.    |.||.|. ..| . . .... | |.  ...  || .|  .|... |.  
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf

VHRSM
.. ..
iysal

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 177-372 6.5e-08 27.1 In-house 32-234 (237) alignment
Range on Protein: 177-372
Range on HMM: 32-234/237.0
ICAAKITVPD-FNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG
| |. .   |   .. | .| |  ||     |||.|. ||  . .|.    .|       .  |      ..||.. |  || |     |  .| ..  .
inatylkgfdgtpkkyiaaqgpless...cddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkeefsdytvrslllskrl

CSNSL-LTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DN--TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
  . . |   |..  | ..   .  . |.    .... .    .    ..    | ||.| .| . . . | .. | |.  . . |.  .|  |..  ||
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

FGTVHRS
.  .|..
yvfihqt

subfamily_PTPN6_pd Subfamily PTPN6 179-383 1.4e-09 32.4 In-house 86-303 (306) alignment
Range on Protein: 179-383
Range on HMM: 86-303/306.0
AAKIT--VPDFNRTMILTQVPdLssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLL--SGTYSTYGKMFVNNKKVESavgMTEYCLEIFPD---
|  |.  |.. ... | ||   |     ..|||||. ||.   .|.. . .| . ..  .    . . ..|||. |.| . .|   ...| |  .     
anyikkevkgsdksyiatqgc.l..ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks...ladYilRelsvskk

-GCSNSLLTTVYHLHNWR-----QKRG--LEVVTDLVATMEKVMKV-NDNTVLMSMNGTGRAGTMLTLFTAMLQVQ---KGKEVNAKETLASLRAERCGI
   ...     || ..|      ...|  |. ..|. . .|....  .  .|    .| || ||.. . . . ...      ... ...  |.|. | |.
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

VDNIDQFGTVHRSMACWFKNNSTN
|   .|.  |..... . ..... 
vqteqqykfvykaikkyietkkkl

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 183-370 1.1e-23 77.4 In-house 109-302 (346) alignment
Range on Protein: 183-370
Range on HMM: 109-302/346.0
TVPDFNRTMILTQVPDLSSAPDIADFWRMIHQESIASVVIAVM--PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTT
 . .|.. .|..|.|.. .   . ||| ||.|| |  | . |    |  |   ..    | |   ||||.||.. . .    || .|..|.| |.|..  
vifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq

VYHLHNWRQKR----GLEVVTdLVATMEKVMKVN-DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVH
|.|   |.. .     | ..  ..  .    .|.     ..|. |.||| ...  . |. |.. | | |  | . ... .| | |. . |. ...
vhhhapwkhlqqppktlpiik.mihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 184-373 7.1e-10 33.4 In-house 79-272 (281) alignment
Range on Protein: 184-373
Range on HMM: 79-272/281.0
VPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPlLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTT
  . ..  | || |  .|   ...||.|. ....  .|.    .|       .  |    .  .||.. |.... |.   . |  ...  ... .  .. 
gykgekeyiatqgPvPas...lvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveq

VyHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQV-QKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
. .  .| ..   .  ..|.   ..|.|....      |.    | ||.|| ..| ... .| .. .|.. |...|.|| ||  .|  . |.  |.. .
l.aytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav

subfamily_PTPRG_pd Subfamily PTPRG 187-383 1.5e-11 38.2 In-house 89-293 (563) alignment
Range on Protein: 187-383
Range on HMM: 89-293/563.0
FNRTMILTQVPDLSSapdIADFWRMIHQESIASVViAVMPLEVT----LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFP------DGCSNS
 ..  | || |  .    . |||||| ..  | .|  .  |.       ..  |    .  |||.. |. .. |  .  |.  | |        . | . 
kskafiatqgplkdt...fddFWrmiWeqnvaiiv.mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdte

LLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.| . ||  .| ..   |  .  .  ..|  . | .    .|    .|.||.|| . | | . |.|. . ||  ..|  .||.|  .| ...|.  .|  
klvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda

MACWFKNNSTN
.  . . . |.
lleaiaskete

0036282 (Phosphotyrosine protein) phosphatases II 189-370 9.7e-10 33.9 In-house 17-163 (174) alignment
Range on Protein: 189-370
Range on HMM: 17-163/174.0
RTMILTQVPDLssapdiadFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGtystygkmfvnnkkvesavgmteycleifpdgCSNSLLTTVYHLHNWR
.  |..|.|          ||.|.....| .||    . |  |  .  . .                                  ...|  ...... . 
prliagqgpla........fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylp

--Q--KRGLEVVTDLVATMEKVMKV--NDNTVLMSMNGTGRAGTMLTLFTAMLQVQkGKEVNAKETLASLRAERCGIVDNIDQFGTVH
        |... ..|  .|....   .  ..   . | ||.||.  ..  . .    . |.| .....||  |.|.| . .|.  ..
wpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 189-373 3.3e-07 24.1 In-house 91-275 (439) alignment
Range on Protein: 189-373
Range on HMM: 91-275/439.0
RTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEVTLqqILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTV--YHLHN
.  | ||.|         ||||.. ..  . .|     .|       |  | .   || . |   .       .   . .| .  ..    ||  .|   
klyiatqgpkke...ttddfwrlviekktvtivmltnlvesyk..ywp..sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyia

WRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
| .|      . ..  .  .   ||.      |.    | ||.||...|  |. |..  ..|. |  .  || .|  .|... |.  .. ..
wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav

subfamily_PTPRD_pd Subfamily PTPRD 191-382 1.5e-14 48.6 In-house 93-286 (564) alignment
Range on Protein: 191-382
Range on HMM: 93-286/564.0
MILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLsGtYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNW
 | || |    |. |.|||||. .. ....|.     | .   ...  |   |   |||.. |. .. |    ..   ...     |.|   . .|  .|
yIAtqgP...laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsW

RQKRGLEVVTDLVATMEKVMKVNDN----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
 ..   |  |.|.. ..|| ..| .    .|    .| || || ...   . .... | |.  .... ||..|  .|.. .|.  .|. ..   .  .|
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_PTPRA_pd Subfamily PTPRA 191-384 6.7e-14 46.5 In-house 103-302 (330) alignment
Range on Protein: 191-384
Range on HMM: 103-302/330.0
MILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILPllSGTYSTYGKMFVNNKKVE--SAVGMTEYCLEIFPDGC--SNSLLTTVYH
 | .| |   .   . |||||| .   |..|.     |      .|  |  .    |||.. |. ....   .. . .....  ||..   .| | . .|
fiaaqGPkeet...vedfwrmiweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfh

LHNWRQKrGLEV----VTDLVATMEKVMKVNDNT-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.. | .  |. .    . .|.. ..|. ... .. |.    |.||.||...| . . .|.  . |.  |.. .||. |. .|    |.  ... .  .. 
ftswPdv.GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

NNSTNE
   |. 
ygdtel

0051082 (Phosphotyrosine protein) phosphatases II 191-369 2.8e-06 22.5 In-house 15-145 (151) alignment
Range on Protein: 191-369
Range on HMM: 15-145/151.0
MILTQVPdlssapdIADFWRMIHQESIASVVIAVMPLEVTlqqI----LPLLSgtystygkmfvnnkkvesavgmteycleifpdgcsnsLLTTVYHLHN
..... |        |||....... | ..|    . |          || |.                                     .  . .....
lyrsggp.......ladflellkelgiktivnlrseeerg...ycpeylpelg.....................................ievlhipild

WRQKRGLEVVTDLVATMEKVMKV-NDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkeVNAKETLASLRAERCGIVDNIDQFGTV
|      .    ... .|....  | ...   . | || ||.  |.  .|.      |.. |.|. .|. |.|.|   .||  .
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

0044763 (Phosphotyrosine protein) phosphatases II 192-372 3.5e-06 22.3 In-house 31-166 (178) alignment
Range on Protein: 192-372
Range on HMM: 31-166/178.0
ILTQVPDlssapdiADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS---GtystygkmfvnnkkvesavgmteycleifpdgcsnslltTVYHLHNW-
.|.. |.       ||........ | ..|    .||   .. .|      |                                         |.  .. 
ylgslpp.......addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipip

-RQKRG-LEVVTDLVATMEKVM-KVNDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkEVNAKETLASLRAERCgIVDNIDQFGTVHRS
       || . ..|. .|... . . ...   . | ||.||.  ..  . .      ... | .. .|. |. || | .|   ... 
DhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef

0051429 (Phosphotyrosine protein) phosphatases II 199-379 2.5e-11 39.3 In-house 26-227 (272) alignment
Range on Protein: 199-379
Range on HMM: 26-227/272.0
LSSAP---DIADFWRMiHQESIASVVIAVMPLEVTLQQILPLLS-------------GTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTV
.|..|   ..|||||. ... | ..|    . |.  ..  ...               .  .||...| . ..|    .. . |..    . ....  ..
rsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh

YHLHNWRQKRGL-EVVTDLVATMEKvmkvNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVN--------AKETLASLRAERCGIVDNIDQFGTVHRS
.| ..|       | . .|.. . .    . . .   . | .| ||.  |.  .|.| .   |.        . |... ||| | |.| . .|.  ... 
lhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

MACWFKN
.. ....
llellrs

0046846 (Phosphotyrosine protein) phosphatases II 200-379 2.6e-12 42.3 In-house 22-175 (176) alignment
Range on Protein: 200-379
Range on HMM: 22-175/176.0
SSAP---------DIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGtYSTY-GkmfvnnkkvesavgmteycleifpdgcsnsllttVYHLHNWR-
.|.|         ..|||..|.... |  ||    . |    ..  . .  . ..                                     |. ..|. 
gsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi..................................qylhlpwpD

-QKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFtamlQVQKGKEVNAKETLASLRAERC-GIVDNIDQFGTVHRSMACWFKN
 .   || . .|.. .... | . ...   . | ||.||.. ..     ....| ... |.|| .|. |. |.| . .|   ... .  ..|.
hgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellllkk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 204-379 7.1e-10 33.3 In-house 76-266 (270) alignment
Range on Protein: 204-379
Range on HMM: 76-266/270.0
DIADFWRMIHQESIASVVIAVMPLEVTLQQ---ILPLLSGTYS--TYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLttVYHLHNWRQ-----KRG-
 . .||||| .|   ..|..    |   ..     |  ...    ..||. | . . | . |     |..  .| .. |.   .. ..| .     . . 
tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreeds

LEVVTDLVATMEKVMKVNDNT------VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
    ..|......| ......      .    .| ||.||...| .|.  ... |.|.  . .. || .|. .|.  .|.  ...... . . 
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

0049260 (Phosphotyrosine protein) phosphatases II 204-370 1.5e-07 26.7 In-house 21-143 (152) alignment
Range on Protein: 204-370
Range on HMM: 21-143/152.0
DIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLsgtystygkmfvnnkkvesavgmteycleifpdgcsnsllttVYHLHNWRQKRGLEVVTDLVATM
..||||||...  |  .|    .|| .  .   .                                            |. ..|      .    |   .
tladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhgvpdlsqlllfll

EK----VMKVNDNTVLMSMNGTGRAGTMLTLFTAMlqvqkgKEVNAKETLASLRAERCGIVDNIDQFGTVH
.       . . ...   . | ||.||.  ..  .      . |...|..| .|. | |.| | .|   ..
lfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_PTPN9_pd Subfamily PTPN9 250-373 4.4e-06 20.9 In-house 164-286 (297) alignment
Range on Protein: 250-373
Range on HMM: 164-286/297.0
VNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVvTDlVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKET
..| | |    .| . .  .|| |  .|  . .  |.. |.|..| | .. ..  .|    .   |.    | ||.||. ||  .. ....   |.  ||
iknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav.ke.lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvet

LASLRAERCGIVDNIDQFGTVHRSM
.  ||. |   .   .|.   . ..
vkllrtqrafsiqtpeqyefcylav

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 259-388 9.5e-07 22.8 In-house 169-299 (305) alignment
Range on Protein: 259-388
Range on HMM: 169-299/305.0
VGMTEYCLEIFPDGCsNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKE-TLASLRAERC
  .||  | |   |. ... .| ||  .| ..      . ..  .||       .|.    | ||.|... |   . |.  |. ..  .  |  .| .| 
akvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrn

GIVDNIDQFGTVHRSMACWFKNNSTN-EEVQR
  ..  .|.  ||. .  .|...    |||..
nsiqtdaqylfvhqvilnyfrkkklldeevke

PTPc_DSPc_SM00012 280-373 3.9e-15 51.3 In-house 3-103 (105) alignment
Range on Protein: 280-373
Range on HMM: 3-103/105.0
TVYHLHNWRQKRGLEVVTDLVATMEKVMKVND------NTVLMSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNIDQFGTVHRS
..|| ..| ..   | ..... ....|.|..       ..|... .| ||.||. .| ... |..|. |||. .... .|| .| | |.. .|.  ..| 
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

M
.
l

subfamily_DSP23_pd Subfamily DSP23 291-370 4.7e-06 21.3 In-house 65-139 (148) alignment
Range on Protein: 291-370
Range on HMM: 65-139/148.0
RGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFtamlqVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVH
  || | ..|  .|.  . |.   .  . | ||.||||. .     . | ... | |..| .|  | | |. ..|   |.
paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacy.....lvkerklaaaeaiaevrrlrpgsvetveqeklvr