Synonym: CELE_C15H7.3, CELE_C15H7.3
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 99-393 | 7.1e-120 | 394.0 | In-house | 2-301 (302) | alignment | ||
Range on Protein: 99-393
Range on HMM: 2-301/302.0
KKEEVKEPWSEEEPAKRMVANgfFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPD
|.|| ||.|.||| ||..|.. ..|..| .||..|..|.....|..||.|..|....|.||....||||.. |.|...|.|..||...|..||.|.|.
kveeekekWveeeeakklvks..ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpk
LSSAPDIADFWRMIHQESIASVVIAVMPLEV--TLQQILPLLSGTYSTYGKMFVNNKKVESAVGMT-EYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEV
..|......||||..||.|.||||.|.. |. ||....|..||.|..||||||||.|||.|.... .|..|..|.|||||.|..||.|.||.||....
vdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvk
VTDLVATMEKV----MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVV
...|..|..|| .|...|||..|.||.||||..|||..|. ..|||||.|.||...|.|..|. .||...|. ..........|.. |..|...|..
yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkke
EF
|.
ev
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 100-382 | 3e-51 | 170.0 | In-house | 19-304 (308) | alignment | ||
Range on Protein: 100-382
Range on HMM: 19-304/308.0
KEEVKEPWSEEEPAKRMVAngFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLtNGPESFICAAKITVP--DFNRTMILTQV
.....| .. .|.. . .... |.. ..|.... |. ....|..| | .|... . ||| ... ..|.| .... ...|..|.||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqg
PDLSsapDIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRG
| . ..|||||.... . .| . | .. | || | .. .|||..|.....|. ..| . ||. . |...|. |..| .||
Plpn...tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv
LEVVTDLVATMEKVMKV--NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
. ...|.. .|.| |. . ..| ....| ||.||...| ... |..|...|.. |... || |.| | . .|. ..| .....|. |
PpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 101-380 | 6.7e-44 | 145.9 | In-house | 10-292 (297) | alignment | ||
Range on Protein: 101-380
Range on HMM: 10-292/297.0
EEVKEPWSEEEPAKRMvaNGFFTTTNVGGTFKQTDNFKTPmDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPE-----SFICAAKITVPDF-NRTMILT
| . .|.| .. .... . . .| . |.. ..| . |. ...|..| | .|... . |||. .. ..|.| ....|. .|..|.|
esipiplsvldlllll..ekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat
QVPdLSSapDIADFWRMIHQESIASVVIAVMPLEVT--LQQILPLLSGtysTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSnsLLTTVYHLHNWRQKRG
| | |.. ..|||||.... . ..| . | .| | .| |||...|...||| |.| . ||. ..|.| . |... ..|
qgP.lpe..tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgv
LEVVTDLVATMEKVMK------VNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNN
. ...| .|.|.. . .. ....| ||.||........ |..|...|...|... || |.|.| . .|. ... .. ..|..
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 106-378 | 1e-46 | 155.1 | In-house | 4-287 (288) | alignment | ||
Range on Protein: 106-378
Range on HMM: 4-287/288.0
PWSEEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTN----GPESFICAAKITVPDFNRTMILTQVPDLS
..| || .|.. . .|.. |.. ....... |. ....|..| | .|.. . |||.. .. ..|.| |......|..|.|| | .
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn
sapDIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD----GCSNSLLTTVYHLHNWRQKRGL
..|||||.... . .|. . | .. | || |.. |||...|.....|. ..| . ||. . |...|. |..| .||
...tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp
EVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
. ...|.. ...|.|. . .| ....| ||.||...|.... |..|...|.. |... || |.|.| . .|. |.. .. ..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 107-392 | 5.1e-53 | 175.8 | In-house | 3-291 (317) | alignment | ||
Range on Protein: 107-392
Range on HMM: 3-291/317.0
WSEEEPAKRMVANGFfttTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssA
..... .......| | . |.. ...| . |. ....|..| | ||... . |||.. . ..|.| ...|...|..|.||.|
ldlllalldllksdf...talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...p
PDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDL
..|||||.... . ..| . . | .| || |.. |||...|.....| |.| ..||. ..|.|.|. |..| ..| . ..|
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll
VATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVVE
.. .|.| .. . .. ....| ||.||........ |..|...|...|... ||. |.|.| . .|. ... .....|.. | |........
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 107-377 | 3.6e-46 | 153.3 | In-house | 2-277 (278) | alignment | ||
Range on Protein: 107-377
Range on HMM: 2-277/278.0
WSEEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDLSsa
.| .. .|... .. | . |.. ..||... |. ...|..| | .|... . ..|||.. . ..|.| .......|..|.|| | .
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe..
pDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVAT
..|||||.... . ..| . . | .. . .|.. |||...|...|.|. ..| . ||. . |...|. |.|| ..| | ...|.
.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf
MEKVMK----VNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
...|.. | .. ....| ||.||...|.... |..|...|.. |... || |.|.| . .|. ... .....
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 129-391 | 3.7e-53 | 176.1 | In-house | 17-291 (297) | alignment | ||
Range on Protein: 129-391
Range on HMM: 17-291/297.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
|.. .... ... |. ....|..| | .|... . |||.... ..|.| ....|..|..|.|| | . ..|||||.... . ..| . .
kefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmltelv
E---VTLQQILPLLSGTYSTYGKMFVNNKKVES--AVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLM
| .. .| || | . |||...|....||. ..| . ||. . |...|. |..| ..| | ...|.. .|.| | . .. .
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH
SMNGTGRAGTMLTLFTAMLQVQ---KGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVV
...| ||.||........ |.. | ..|. .|.. .|| |.|.| . .|. ... .....|.. | |.....|.
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 129-377 | 1.3e-48 | 161.2 | In-house | 16-272 (273) | alignment | ||
Range on Protein: 129-377
Range on HMM: 16-272/273.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
|.. ..|.... |. ....|..| | .|... . |||..|. ..|.| .......|..|.|| | . ...|||||.... . .| . .
eefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvrviVmLtelv
E---VTLQQILPLLSGT-YSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMS
| .. | || |. . ||||..|.....|. ..| . ||. . |...|. |..| ..| . ...|. .|.|.| | .| ..
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC
MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
..| ||.||...|.... |..|...|...|... || |.|.| . .|. ... .. ..
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 129-381 | 8.5e-14 | 45.9 | In-house | 26-283 (303) | alignment | ||
Range on Protein: 129-381
Range on HMM: 26-283/303.0
GTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNgpESFICAAKITVpDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE
|.. .. | | | .||.| | | . |||.. |.| |. . . | .. ||||.| .| ||||.|| .. . |.. . |
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd..ssyihasylel.dsskkailtqlplshta...adfwqmiieqkvkcvlllltdse
VT---LQQILPLlSGTYSTYGKMFVNN---KKVESAVGMTEYCLEIfPDGCSNSLLtTVYHLHNWRQKRGL-----EVVTDLVATMEKVMKVN--DNTVL
. ..| . . . .. |.|| . | . | . .| .|.| |.| ..| .. ..| .. . | ||
ydklggdsvfpr.nqdflkfeersirvgefkrvelgdgwvlkvlsv.sngdyksfl.hvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvy
MSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
||. | |||||. . || | ... .. | .| | |.|. || |. .| .|
mslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 131-371 | 4.3e-12 | 40.9 | In-house | 17-263 (273) | alignment | ||
Range on Protein: 131-371
Range on HMM: 17-263/273.0
FKQTDNFKtPMDSCPSFKN--NMHKIRAPDCPIPEEKLVKLTNGPEsFICAAKIT--VPDFNRTMILTQVPdLSSApdIADFWRMIHQESIAsvVIAVMP
||. ..| |.|.| . |. |..| | . .| ||| . .| |. | | . . ..|..| | | . ..|||.|. . . |||..
fkelrelk.pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGP.lPet..vkdfwqmvweqkae..viamvt
LE-----VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND---NTVLMS
|| | .. | . . .... |.. ||. |.. |.. ..| . .. .| ..|. . .| .... |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhc
MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHR
| ||.||..|. ... ... ||.. ||.. .|| | |.| ||. |..
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 132-373 | 2.8e-13 | 44.2 | In-house | 24-286 (296) | alignment | ||
Range on Protein: 132-373
Range on HMM: 24-286/296.0
KQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLT--NGP--ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL
|.| .... . |.|. | | ... .. . | |. .| . .| |. . .. | |. | .. . .|||....| | .||. .
kltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkket...vdefWrlvydeeisavvvLtktf
EVTL--QQILPLLSgtYSTYGKMFVNNKKVESAVGMTEYCLEIFPD----------GCSNSLLTTVYHLHNWRQKRGLEVV-TDLVATMEKVMKVNDNT-
. . .. .| | ||..||. .... .. . . . . . ....| | . . .. . |. ...| .. ...
dfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd
--------VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
| .| .|..|.| |.. .. .|.| .||. | . || .| ..|.|.... . .
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 133-371 | 3.6e-14 | 47.3 | In-house | 26-274 (288) | alignment | ||
Range on Protein: 133-371
Range on HMM: 26-274/288.0
QTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKIT-VPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTL
|... .. |. | . .| | |. ... ||| .. . .| |. . . ..| || | |. ..|||.|.... .|. . . |
qkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst...lnDFWlmvyeqkssviVmllskeelgk
Q---QILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKrGLEV-VTDLVATMEKVMK--------VNDNTVLMSMN
. . | | ..|.. | |.|... . |. |.. . .. . .|..| . |. .|.. ...| . .. |.
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpel.GvPasPetllqfldevesayeavqrksktPlvvhCsa
GTGRAGTMLTLFTAMLQVQKGKEV-NAKETLASLRAERCGIVDNIDQFGTVHR
| ||.|.. ...|. ...||. . . . . ||..| | . .|. .
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsye
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 137-381 | 3.7e-09 | 30.6 | In-house | 39-294 (310) | alignment | ||
Range on Protein: 137-381
Range on HMM: 39-294/310.0
FKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTN---GPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEVTLQQ
. . . ..|..||| | | .. |||. | .| | . . |.| .| | | |||||| || |... . | .
kqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqh...tiidfwrmifqeraesilllckvgeegrpk
---ILPLLsGTYSTYGKMFVNNKKVES-AVGMTEYCLEIFPDGCS-----NSLLTTVYHLHNWRQKRGLEVVTDLVATMEK--VMKVN-DNTVLMSMNGT
| | | ||| . | | | . . .. . || | | .| . | . . |. . . .| |. |
cvgywpsl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagk
GRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
.| .....| .. ....|..|.|.| . |. .| ... |. ..| . . . ..
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarget
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 138-373 | 3.4e-14 | 47.5 | In-house | 31-267 (288) | alignment | ||
Range on Protein: 138-373
Range on HMM: 31-267/288.0
KTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQ---I
....|. || .| . | . | . |||.. |. .| | .. ..| .| .| | | .|.|. .. . .|. || ...
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaey
LPLLSGTYSTYGKMFVNNKKVESAVGMT-E-YCLEIFPDGcSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFT
.|. | .|.. || . . . . | | | .. . . ||..| .. | . .| . ... |..| .|.||.||. .
fPsklGekarigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlilili
AMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
|. ... . .. ||.||.|| . |. ||| .
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcv
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 141-379 | 2.4e-43 | 144.4 | In-house | 46-306 (307) | alignment | ||
Range on Protein: 141-379
Range on HMM: 46-306/307.0
MDSCPSFKNNMHKIRAPDCPIPEEKLVKLTN-----GPESFICAAKI--------TVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
|. ....|..| | .|... . |||.. .. ..| | . ..|..|..|.||.| . ..|||||.... . .| .
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...tvedFwrmlweqgvtvivmltelv
EVTLQ---QILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMS
| . . | |. |.. |||...|.....| |.| ..||. . |...|. |..| ..| . . .|.. .|.|.| . .. ..
elgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC
MNGTGRAGTMLTLFTAMLQVQKGKE---VNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
. | ||.||........ |..|... |.. |... ||. |.|.| | .|. ... .. ....
saGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 141-379 | 5.1e-14 | 47.0 | In-house | 42-282 (318) | alignment | ||
Range on Protein: 141-379
Range on HMM: 42-282/318.0
MDSCPSFKNNMHKIRAPDCPipEEKLVKLTNGPES-FICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS
.... .|| | | | || .|.. ..| .| | | ... | .| | . | |||||. . | .|. | . ...
lepvnkaknryanilaydht..rvkLqmlegeegsDyinanyidGyrrkkayiaaqaP...lpetieDfWrmvWeqnsavivmltqeeergkakvhryWP
-GTYSTYGKMFVNNKKvesAVGMTEYCLE---IFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN-----DNTVLMSMNGTGRAGTMLTL
.|||. |. |. | ...| | . .....| || .| .. .| ...|.. . .| |.. . .| | ||.|. ...
skgsrsygklvvelke...evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiav
FTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
. . .... . |. .| || .| .| ||. .. . .
dillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 142-378 | 2.7e-10 | 34.8 | In-house | 33-278 (307) | alignment | ||
Range on Protein: 142-378
Range on HMM: 33-278/307.0
DSCPSFKNNMHKIRAPDCPIPEEK-LVKLTNGP-ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
. .|. | .| | | . . .| ..| .| | . . . .| .| | .. . .|| |. || . ||.. . .| . .| |
vtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplent...qysfwamaiqekvesvimlckvielakikceqywp
LLSGTYSTYGK----MFVNNKKVESaVGMTEYCLEIFP---DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVmKVNDNTVLM-SMNGTGRAGTML
| | ..|. . |.| .. . | .... | ...| . . .|| .. .. . .| | . . | |.. | ||.||..
leegqklvfgeapntisvanlgakk.lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav.rydtnpvvvhcsaGvGrsGtiv
TLFTAMLQVQKGKEVNA-KETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.. . .. .|.. . |. . ||..| . . |. .|| . .|
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 143-382 | 5.5e-42 | 139.5 | In-house | 21-279 (284) | alignment | ||
Range on Protein: 143-382
Range on HMM: 21-279/284.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTN-----GPESFICAAKITVP-----DFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEV---
|. ...|..| | .|... . |||.. . ..| | .... ......|.|| | . ..|||||.... . .| . |
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelvengre
TLQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV------NDNTVLMSMNGTG
| || |.. |||...|.....| ..| . ||. . | ...|. |..| ..| . ..||.. ...| .. . .| ....| |
kcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg
RAGTMLTLFTAMLQVQKGK---EVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
|.||...| ... |..|.. .|.. |... || |.| | . .|. |.. .. ..|. |
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 143-379 | 9.5e-42 | 138.7 | In-house | 4-248 (249) | alignment | ||
Range on Protein: 143-379
Range on HMM: 4-248/249.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTN----GPESFICAAKITVPDFNRTMILTQVPdLSSapDIADFWRMIHQESIASVVIAVMPLEV---TLQQIL
|. ....|..| | ||..... |||. . ..|.| |......|..|.|| | |.. ..|||||.... | ..| . . | . .|.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP.lpe..tvedfwrmlwelgitvivmLtslvelgrekcaqyw
PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMSMNGTGRAGTMLT
|| |.. .||...|....||. ..| . ||. . ....|. .... ..| . . ||.. .|.|.| . .. ....| ||.||...
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia
LFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
..... |..| ..|...|... || |.|.| | .|. ... .. ....
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 143-378 | 7e-39 | 129.1 | In-house | 2-244 (245) | alignment | ||
Range on Protein: 143-378
Range on HMM: 2-244/245.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPES----FICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLE---VTLQQIL
|. ....|..| | .|... . .|||.. ... .| | ..........|.|| | . ...|||||.... | ..| . | |. .|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqyw
PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLE---VVTDLVATMEKVMK--VNDNTVLMSMNGTGRAGTMLTL
|| |.. |||...|.....|. ..| . ||. ..|.. |. ..|| ..| . . |.. ..|... | .. ... | ||.||....
pl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa
FTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.... |..| ..|.. |... || |.|.| . .|. ... .. ..|
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 143-377 | 1.8e-36 | 121.3 | In-house | 3-242 (243) | alignment | ||
Range on Protein: 143-377
Range on HMM: 3-242/243.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLtNGpESFICAAKITVPDfnrTMILTQVPDLSSAPD-IADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGT
|......|..| | .|.. . ||| .| ...|.| |.|.. ..|.||.| .. | |.||||.... | ..| . | . .. .. .|.
siallpenlsknrysdilpydhsrvkl.eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge
YsTYGKMFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN------------TVLMSMNGTGRAGTML
. |||...|.....|. ..| . |.. . . ..| . || ..| . ..||.. ...| .. .. .... . | ||.||..
v.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli
TLFTAMLQVqkgkEVNAKETLASLRAERCG-IVDNIDQFGTVHRSMACWF
.... .|.. .|.. |... ||. |.| .| . .|. ... .....
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 143-379 | 1e-08 | 29.5 | In-house | 42-298 (300) | alignment | ||
Range on Protein: 143-379
Range on HMM: 42-298/300.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLT---NGPESFICAAKI--TVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQI
|. . ..| .| | .| |. |.|. . . .| |..| .| .|. | .| | . |||.|. .. .. .|. | .
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqlivmlteeeedgkeksfky
LPLL--SGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPdgCSNSLLTTVYHL--HNWRQKRGLEVVTDLVATMEKVMKVNDN-------------TVLMS
.| | . ..|| | .| .|.. .. .|.. . ||.|| .| ... | |.. . .|.| | . ..
fPkleskkktvefgkfkvttkfsedsdsvittglklkh..lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC
MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
.| ||.| ... . .....|.. |..|| || | .|... |. |.. . ..||
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
|
|||||||||
DSPc_SM00195 | 144-377 | 6.4e-44 | 145.6 | In-house | 20-262 (263) | alignment | |||
Range on Protein: 144-377
Range on HMM: 20-262/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
. .|.|..| | .... ... |||.. . ...|.| |.... ....|.|| | ..|||||. .| . .|. ... | . .. |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp
LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLF
||...|.||. |....||. .. . ||. .|.... .|.|. .|| .. . ..... ...| | . .| .. .| ||.||..|.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid
TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .....|.|. .|.. .|| .|.|.|.. .|. .... .. ..
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
PTPc_SM00194 | 144-377 | 6.4e-44 | 145.6 | In-house | 20-262 (263) | alignment | |||
Range on Protein: 144-377
Range on HMM: 20-262/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
. .|.|..| | .... ... |||.. . ...|.| |.... ....|.|| | ..|||||. .| . .|. ... | . .. |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp
LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLF
||...|.||. |....||. .. . ||. .|.... .|.|. .|| .. . ..... ...| | . .| .. .| ||.||..|.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid
TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .....|.|. .|.. .|| .|.|.|.. .|. .... .. ..
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 144-372 | 1e-12 | 42.5 | In-house | 27-261 (283) | alignment | ||
Range on Protein: 144-372
Range on HMM: 27-261/283.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVP---DFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVM---PLEVTLQQILPL
. | ..| .| | . . . |.| . ....| |. |.| . .. | .| | | . . |||.|...| |...|. |.. | |
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsP.ldrt..vvdfWkmvfdekitaivmltklqedlrikCsqyWPk
lSGTySTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVAtMEKVM----KV-NDNTVLMSMNGTGRAGTMLTLF
|. ||.. | .| . .. | . . . ..|| . | . .| . .. || ..||. . . |. .| ||.......
.rGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfiaas
TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
... ... |. ... .| .| ..| . ||. ||
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhel
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 146-379 | 1.9e-22 | 75.4 | In-house | 29-274 (278) | alignment | ||
Range on Protein: 146-379
Range on HMM: 29-274/278.0
SFKNNMHKIRAPDCPIPEEKLVKltngpeSFICAAKITVPdfNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPllSGTY
. .|..| | .| . . || .| | |... ....|.|| | .||||||.... | ..| . .| . | | .| .
lylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggs
STYGKMFVNNKKVESAVGMTEYCLEIFPD----GCSNSLLTTVYHLHNWRQKRGLEVV-----TDLVATMEKVMK--------------VNDNTVLMSMN
|||...|.....| .| |.. |. |..|...| . .|. .....| . .. .
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa
GTGRAGTMLTLFTAMLQVqkGKEVNAKETLASLRAERCG-IVDNIDQFGTVHRSMACWFKN
| ||.||. ... . .. .. |.. |... || |.| .| | .|. ... .. ....
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 146-374 | 3e-14 | 47.7 | In-house | 50-276 (315) | alignment | ||
Range on Protein: 146-374
Range on HMM: 50-276/315.0
SFKNNMHKIRAPDCPIPEEKLVKLTNGpESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTY
|| ..| | | .. |.. .. .. |. | . .| | .| | .| . ||||....| |. .|. | .. .|
kqknryiniiaydksrvqlpllendph.sdyvnanfidGynkkrryiaaqgpnvas...vkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy
GKMFVNNKKVESavgMTEYCLEIFpDGCSNSLLTTVYHLH--NWRQKRGLEVVTDLVATMEKVMKVNDNTV----LMSMNGTGRAGTMLTLFTAMLQVQK
||. | |. | |||. . ... . .|. || | . . . |. . .|.. ..|.| . .| ||.||..|| . . |..
Gkitvtrkseev...nteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea
GKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMA
. .. . . .|. | ..|. ..|. .. .
enaidvynfitgvrqnrikmvqvaeqyqfiydall
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 146-376 | 2e-13 | 45.0 | In-house | 31-258 (267) | alignment | ||
Range on Protein: 146-376
Range on HMM: 31-258/267.0
SFKNNMHKIRApDCPIpEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTY
. ...... .| ... | | . | .| |. . ....|.|| | |. . |.||. .||.. .. .|. . . .... | | |
eknqernrldd.nlpy.ddtrvilrtkeeeyinasyvegyktknafivtqdp.lknt..itdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakky
GKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLlTTVYHLHNWR----QKRGLEVVTDLVATmEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGK
. |. . ||. | |.|. ..| .| |. . ..| ... . | |. .| ||.||.|.. . . ....
qdltvehslekeendyqiitlelkfknesahn.vtlyyykkwnintnnkpylkplfgilak.nqlengnrPlvvacsdGvGrsGtflvidsqlerakteg
EVNAKETLASLRAERCGIVDNIDQFGTVHRSMACW
.. . | .| | |.|| ... .|...| .
vsdifdflrkirsqriglvdtkeryiyihellaey
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 146-377 | 4.4e-09 | 30.7 | In-house | 31-270 (285) | alignment | ||
Range on Protein: 146-377
Range on HMM: 31-270/285.0
SFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNR-TMILTQVPdLSSapDIADFWRMIHQESIASVVIAVMPLEVTLQQI---LPLLSGT
... | | | || | | | .| |. . .| .. | | || | | ..|||.||.|| || |.. . .| ... | |
ayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgp.lpe..tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge
YSTYGKMFV--NNKKVESAVGMTEYCLEIF--PDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTV---LMSMNGTGRAGTMLTLFTAM
.|| . . | |. | .| . | .|. | .. | .. | .. . | ||| . . | ||. |.. . |
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat
LQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... . ... . . .|| | |.. || .. . .|
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 148-387 | 7.8e-18 | 59.6 | In-house | 46-296 (307) | alignment | ||
Range on Protein: 148-387
Range on HMM: 46-296/307.0
KNNMHKIRAPDCPIPEEKLVKLTN--G--PESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS-GTY
|.| | | .| ... |||.. | ..| | | . ... | | | | |||||| . .. .|. | . ... . .
kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv...eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiede
STYGKMFVNNKKVESAVGMTEYCLEIFPDG-CS----NSLLTTVYHLHNWRQKRGLEVVTDLVATMEKV---MKVNDNT-VLMSMNGTGRAGTMLTLFTA
||.. |. . |.. .. |.. . .| .| . || .|. || . |. .|.| | | |. .|.||.|....|
vqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsl
MLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQ
. |... ..|. || || .| .|....|. ..|... . . |.|.|.
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 148-381 | 1.6e-17 | 58.5 | In-house | 45-283 (288) | alignment | ||
Range on Protein: 148-381
Range on HMM: 45-283/288.0
KNNMHKIRAPDCPIPEEKLVKLTNGPE----SFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL---EVTLQQILPLlSG
.| .| | .. .|| |||....| .| |. | . . ... | || | .. . |||...... . .| . . . .. | ..
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt...vndfWelvyenktstivmltelveggktkCeeYWPd.ad
TYSTYGKMFVNNKKVESAVGMTEYCLEIFpdGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNT----VLMSMNGTGRAGTMLTLFTAMLQ
. ||.. | .... ... |.. . | .| |. | .. | ..|.. ...| |.. . ..| ||.|| ..| ... .
kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalida
VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
|.. . .. .|.| || .| .|.. |. ... .. ....
veeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 148-372 | 4.5e-14 | 47.0 | In-house | 41-272 (314) | alignment | ||
Range on Protein: 148-372
Range on HMM: 41-272/314.0
KNNMHKIRAPDCPIPEEKLVKLTN--GP--ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYS
..| .| | | .. .|.|. | .| || | . | || | . ..||||....| ||.|. ||. . | .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet...vkdfWrlvydencasivmltelvevgrvkClkyWPedte
TYGKMFVNNKKVESAVGMTE--YCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND----NTVLMSMNGTGRAGTMLTLFTAMLQV
.||.. |. ..| . . .| | .. . .. .| . | |.. . .| | .. ..|. ..|.||.|| ... . . .
vygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi
QKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.. . |. .. .||... .|. .|. ..
eregvvdvfnavktlrsrkvnmveteeqykfiydv
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 148-371 | 9.4e-11 | 36.1 | In-house | 39-269 (280) | alignment | ||
Range on Protein: 148-371
Range on HMM: 39-269/280.0
KNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKIT--VPD--FNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLlSG
.|..| | | .. |||.... .| | . .| . | || | .. .|||.|...... .|. .| | | ..
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlakt...atdfWqmvweqksslivmlttlverGrvkChqyWPe.te
TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
..||.. |. .| .. . | . ... . .| .. . .|.. .|.| |. . .|. | ||.| ...| ||.
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal
VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHR
... ..|. . . .| | .|.. .|. |
ieaaepvypldivrtmrdqramlvqtasqykfvCe
|
|||||||||
subfamily_egg_pd | Subfamily egg | 148-379 | 1.2e-07 | 25.7 | In-house | 38-272 (307) | alignment | ||
Range on Protein: 148-379
Range on HMM: 38-272/307.0
KNNMHKIRAPDCPIPEEKLVKL--TNGP--ESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL-QQILPLLSGTY
.||..| |.. . . ||| .| . || | .. . ..||.| | | . |||||..|| . .|. | . |
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqap.lknt..vddfwrmvfqeevqyivmltsrkeserceyywpkaesds
STY--GKMFVNNKKVESAVG----MTEYCLeIFPDgcsnsllTTVYHLHNWRQK-RGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAML
. | . ..| ||.|. .|. | . .| .| |. . . | . . |. .. .|. ...| .|.|.... .|.|
lvtvpGslrienlkvdskadplfrvtklkl.vGgd.......deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiall
QVQKGKEV--NAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
.. .| . ... || .| |. . .. |.| .. .|..
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 149-375 | 1e-11 | 39.3 | In-house | 46-276 (287) | alignment | ||
Range on Protein: 149-375
Range on HMM: 46-276/287.0
NNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTY-STYGK
.| .| | . .|... | | . . .| |. | .. |... | . | .||..|... . .|. . | . .. . . ..|.
qnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfnta...rnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe
MFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND-----NTVLMSMNGTGRAGTMLTLFTAMLQVQKGK
.. . | |..| ||. .. .. . . |.. || ... .. . .|. .| . | .. ||..... |.. ....
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG
EVNAKETLASLRAERCGIVDNIDQFGTVHRSMAC
.. . | | | . | | ..|. . .
viDvfqvlksqriqkpgsvqtveqykfindivle
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 150-373 | 2.3e-40 | 133.9 | Pfam-A | 1-233 (235) | alignment | ||
Range on Protein: 150-373
Range on HMM: 1-233/235.0
NMHKIRAPDCPIPEEKLVKL--TNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... ||| ..||. .| | .. . ....|.|| | |. .|||||. || . ..|. . | ....| | .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt
YGKMFVNNKkVESAV---GMTEYCLEIFPDGCSN-SLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
||...|..| ... ..| . ||. .. .. . ....|..|| .. | ...|. ...|| | . ..| ....|.||.||...| ... |
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
.....||. .... .||..|.|.|....|. ... .
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 150-373 | 2.3e-40 | 133.9 | In-house | 1-233 (235) | alignment | ||
Range on Protein: 150-373
Range on HMM: 1-233/235.0
NMHKIRAPDCPIPEEKLVKL--TNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... ||| ..||. .| | .. . ....|.|| | |. .|||||. || . ..|. . | ....| | .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt
YGKMFVNNKkVESAV---GMTEYCLEIFPDGCSN-SLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
||...|..| ... ..| . ||. .. .. . ....|..|| .. | ...|. ...|| | . ..| ....|.||.||...| ... |
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
.....||. .... .||..|.|.|....|. ... .
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 150-382 | 4.2e-14 | 48.0 | In-house | 1-176 (182) | alignment | ||
Range on Protein: 150-382
Range on HMM: 1-176/182.0
NMHKIRAPDCPIPEEKLvkltngPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVmplevtL----Qqilpllsgtysty
|..| | .| . .. . . ..| | . . ....|.||.| || ..|||.||.... | ..| .
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt......eelywp.............
gkmfvnnkkvesavgmteycleifpdgcsN--SLLTTVYHLHNWRQKRGLEvVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkEV
. | . |. ..| . . .|.. .|.| . . ... . | ||.||. .. . . .|
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gv
NAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
.. |... .| |.|.| . .|. ... . ...... |
sleeavklvrsrRpgmvitpnqyfflqlallellllkkt
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 150-361 | 1.4e-10 | 35.3 | In-house | 54-267 (290) | alignment | ||
Range on Protein: 150-361
Range on HMM: 54-267/290.0
N--MHKIRAPDCPIPEEKLVKLTNGPES-FICAAKitVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYS
| ..| | | . . | | .| . .. | | . ..|||| . . . |.|||. || .| .|. .| .| | .|
ntefkknrykdvvcndktrvilkdGydGdyvhany..vkGlkamfiltqGal...kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl
TYGKMFVNNKKV-ESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKE
|.|.. | . . . | . . ... | .| |. |. . |.. |. | ||.||. .. ... . .|||
tfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGke
VNAKETLASLRAERCGIVD
.. .. .|| | . |.
ldlldlvralrnsrlnsvq
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 151-372 | 2.8e-11 | 37.8 | In-house | 47-278 (290) | alignment | ||
Range on Protein: 151-372
Range on HMM: 47-278/290.0
MHKIRAPDCPIPEEKLVKLT------NGPESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL---EVTLQQILPLLsGT
.. | .. ..... . | . ....| |. | .. |.|| | . ..|||..| ||... .|. . .|. || | .|
kllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt...lvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dt
YStYGKMFVNNKKVESAVGMTEYCLEIFPDGC-SNSLLTTVYHLHNWRQKRGLEVVT---DLVATMEKVMK--VNDNTVLMSMNGTGRAGTMLTLFTAML
. ||.. .. . |. ...| ||. . .. | |.. || .. .. . ... |.| .. | |. .. ||... ... |..
ka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin
QVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.... .. . | |.| . | | .|. ....
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqi
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 152-365 | 6.5e-08 | 26.7 | In-house | 52-269 (301) | alignment | ||
Range on Protein: 152-365
Range on HMM: 52-269/301.0
HKIRAPDCPIPEEKLV-KLTNGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYSTYGK
.| | | | . | ...| | | | . . .| || | |... ||| |. | . .|. .| .. ||. . |.
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgP.lknt..sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr
MFVNNKKVESAVGMTEYCLEIFPDGCSNSL-LTTV--YHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVN
.. |. |. . . .. .. . || | ..| .. . ..| || | | .. |. .| ||. .... .|. ....
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptie
AKETLASLRAERCGIVDNIDQ
.|.|. || .| | . |
ltealkhlrehrwngvqtnsq
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 165-381 | 1.5e-10 | 35.6 | In-house | 69-289 (293) | alignment | ||
Range on Protein: 165-381
Range on HMM: 69-289/293.0
KLVKLTNGPE-SFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLSgTYSTYGKMFVNNKKVESAVG
|| .|.. .. .| | | .| | || | | .. . |||||.... .|. .| .. | . . .||.. |. .. |.
kLaalkdesgsDYinanyipgynsprefiatqGP.lpet..vddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeled
MTEYCLEIFPdgCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN------DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
. |.| ... .. || | . | . |.. ...| .. .| | ||.|| ..| . . .... |. ..|.||
wvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelRe
ERCGIVDNIDQFGTVHRSMACWFKNNS
||. .| . .|. .|... .....
eRnllvqtekqYifihqcvldllrkke
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 167-370 | 1e-14 | 49.2 | In-house | 61-270 (315) | alignment | ||
Range on Protein: 167-370
Range on HMM: 61-270/315.0
VKL---TNGPE-SFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYSTYGKMFVNNKKVESAV
||| . |. .| |..| | ... | .| | .| . |||||. || ....|. | . .| | . .|.. |. ..|.
vkleviddsPdsdyinasyiksvdddkayiasqgPlkas...vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadt
GMTEYCLeIFPDGcSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN---DNT-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAE
... | . .. .| | .....| .| . .. |. . .| | . . .. . |.||.| .... . |..... |. ... |||.
dgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrak
RCGIVDNIDQFGTVH
| .| ... ..
rpylvqteeeyafiy
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 167-370 | 3.4e-13 | 43.5 | In-house | 60-269 (515) | alignment | ||
Range on Protein: 167-370
Range on HMM: 60-269/515.0
VKL---TNGPES-FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYSTYGKMFVNNKKVESAV
||| . |.| .. |..| | ... | .| | .| . ||||.. || .. ... | . | | .|.. |. .|.
vklevindnPhsdyfnasyipsfdndkayiasqgPnkas...vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleact
GMTEYCLEIFPDgcSNSLLTTVYHLHNWRQKrGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
|.. |.. . ..| | .|...| .| | . | . . | .| . . .. . | ||.| .... . ...... |. ... .|.
ggikrkltvlkg..ddsrtvtqfhfteWPdk.GvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirq
ERCGIVDNIDQFGTVH
.| .| .|. ..
krpylvqtqeqyafiy
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 167-371 | 2.2e-09 | 31.9 | In-house | 27-234 (239) | alignment | ||
Range on Protein: 167-371
Range on HMM: 27-234/239.0
VKLTNGPES-FICAAKITVPDF-NRTMILTQVpdlSSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEY
||.| | | .| |. . | .. | || . ... |||||. || . .|. .| .. . | | .. | .| |
eklsndphsdyinasylrdydgspkayiatqg...cveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir
CLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
. . | .. ||. | .| . | .. |. | . |. | ||.|..| . . . | .| | |. . . ..| .| .|
tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv
DNIDQFGTVHR
. .|. .|
qtseqyvfihl
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 167-371 | 2.4e-09 | 31.7 | In-house | 28-235 (239) | alignment | ||
Range on Protein: 167-371
Range on HMM: 28-235/239.0
VKLTNGPES-FICAAKITVPDF-NRTMILTQVpdlSSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEY
||.| | | .| |. . | .. | || . ... |||||. || . .|. .| .. . | | .. | .| |
eklsndphsdyinasylrdydgspkayiatqg...cveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir
CLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
. . | .. ||. | .| . | .. |. | . |. | ||.|..| . . . | .| | |. . . ..| .| .|
tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv
DNIDQFGTVHR
. .|. .|
qtseqyvfihl
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 168-373 | 9.1e-16 | 52.9 | In-house | 64-279 (305) | alignment | ||
Range on Protein: 168-373
Range on HMM: 64-279/305.0
KLT----NGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVM---PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVG
.|| .. . .| |. . . . . |..| | | . .|||||.| .| . ..|. . . .| | . .|.. |. | ..| .
iltekeslddsdyinasyvdgykrkkkyivaqgP.lknt..vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasd
MTEYCLEIFP-DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNT-----VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
.| |.| |. ..| . |.| .| .. . | |. ...|.| . . .| ||.|. ... |. ...| ..|. | | ||
yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRs
ERCGIVDNIDQFGTVHRSM
.| ..| . ||. .| .
krmkmvqtldqYvflhdal
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 168-382 | 6.7e-15 | 49.7 | In-house | 61-282 (290) | alignment | ||
Range on Protein: 168-382
Range on HMM: 61-282/290.0
KLTNG-PESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAV-GMT
| .. ...| | | .. . . | .| | |. . . |||||| . .. ||.| . .|. .. | .. ..|.. |.... . ...
kieeeegsdYinanfikgvegkleyiaaqgP.Lpkt..lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddfl
EYCLEIFPDGCSNSLltTVYHLHNWRQK---RGLEVVTDLVATMEKVMKVNDNTVLM-SMNGTGRAGTMLTLFT--AMLQVQKG-KEVNAKETLASLRAE
.|.. .. |... . .| ..| . .. . . .|....... . .|. ... | ||.||.... .|. .| .|.. . ...|| .
irtLkveaqkesrkv..yqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkq
RCGIVDNIDQFGTVHRSMACWFKNNST
| .| .|. |....| .... .
raalvqtkeqyelvykavaelvqkele
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 171-378 | 3.6e-15 | 50.9 | In-house | 75-285 (297) | alignment | ||
Range on Protein: 171-378
Range on HMM: 75-285/297.0
NGPES-FICAAKitVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIF
. |.| .. |. |. .. .| || | .. .||||.|. .| .. .|. | . . . .|.|.. | . |.. |. . ||.
ddpdsDyvnasf..vkgnkhrlittqmPmkat...vadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevt
PDGCSNSLLTTVYHLHNWRQKR-----GLEVVTDLVATMEKVMKVNDN--TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDN
. . . |. .| .| . . .|. ..|. . | . .. ..| ||.| .||. . .... |||. ... || || .|
kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt
IDQFGTVHRSMACWFK
.|. |. . .
keqykfvyvavleall
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 171-339 | 1.2e-09 | 32.3 | In-house | 63-229 (281) | alignment | ||
Range on Protein: 171-339
Range on HMM: 63-229/281.0
NGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLEVTLQQ---ILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLE
. .| | | | ..| |||| | . ||||||| || ...|. . || .. .| . . |. |. . . |.
knstdyihanyirspflkrgyiltqgpkketr...adfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrln
IFPDGcsNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQK
. .| .. | | . ..| . . | .. . |. |. | ||.||.... |. ..
lsyeg..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihs
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 174-374 | 2.1e-17 | 58.3 | In-house | 84-287 (298) | alignment | ||
Range on Protein: 174-374
Range on HMM: 84-287/298.0
ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFP
.| |. . . . . |.|| | .. ..|||||. .| |...|. |. . .. | . |||.. |. .. |. .. |..
sdYiNAsflhaykgrnafiatqaPltet...vedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvsk
DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN----T-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
... | .| .| |. | ... ..|| . . . .. .|.||.|| . . . .|.| . | ... ||..|.|.|. .|
kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq
FGTVHRSMA
. .. .
Yvfiyeavl
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 174-373 | 8.4e-09 | 29.5 | In-house | 84-288 (297) | alignment | ||
Range on Protein: 174-373
Range on HMM: 84-288/297.0
ESFICAAKITVPDFNR-TMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNnKKVESAVGMTEYCLEIFPD-
. .| |. |. | . . | || | | .||||.|. .. .. .| | ..| . | ... . | . .| . |
sdyinasaildhdprapayiatqgp...lastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyev.hlvsehiwcddylvrsfylk
G--CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNID
|.. | .| |... |. || | |. ...|.||.|. . . . ...|| ||.. || || .| |.| |
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd
QFGTVHRSM
|| . ..
qfefaltav
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 175-379 | 1.4e-14 | 48.9 | In-house | 58-270 (274) | alignment | ||
Range on Protein: 175-379
Range on HMM: 58-270/274.0
SFICAAKITVPDFN-RTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL---QQILPLLSGT--YSTYGKMFVNNKKVesaVGMTEYCLEI
|.| | | .| . .. . || | |... .|||||||.||.. .|. | .. | .. .||.. ....|. | .| ..
syinanyikGydeeskayvatqGP.lpnt..vadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki...verndysvrk
FPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-------TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
. .... . | .| .. . .. |. ....| . ... .|. | ||.| .. |. |... . |. .. . || .| |.|
lvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv
DNIDQFGTVHRSMACWFKN
.. .|. .|| .. . |.
qtseqyelihralclylkr
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 175-370 | 4e-09 | 31.9 | In-house | 6-154 (172) | alignment | ||
Range on Protein: 175-370
Range on HMM: 6-154/172.0
SFICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVmPLevtlqqilpllsgtystygkmfvnnkkvesavgmteycleiF-----
.| | . .. . | || | ..||||||.... | .| . .| .
dyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnlt.el.........................................lydpel
-------------PDGCSNsLLTTVYHLHNWRQK--R--GlevvtdlvatmekvmkvNDNTVLMSMNGTGRAGTMLTLFTAMlqvqkgKEVNAKETLASL
||.. || .... .. .. . .. . | ||.||. .. . . ... |..| .
lerlgiqylylpwpDhgvp.llellleflefidellalsp.................ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv
RAERCGIVDNIDQFGTVH
|. |.|.| | .| ..
rekRpgavqnpsqyrfly
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 175-368 | 3.8e-07 | 24.5 | In-house | 47-250 (290) | alignment | ||
Range on Protein: 175-368
Range on HMM: 47-250/290.0
SFICAAKITVPDfNRTMILTQVPDLSS----APDIADFWRMIHQESIASVVIAVMPLEVTLQ-------QILPLLSGTYSTYGKMFVNNKKVESAVGMTE
.| | ..|.|. . .|||| | . | .|| |..|| . .|| | . . . | |. ... . |. |. | .. .
dyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet
YCLEIFPDGCSNsLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQ-KGKEVNAKETLASLRAERCGIVDN
|.. |. . . | . |..| . | |.. ..||.. . .. ..| | .. .. .. . . ..|. .. | .|| .| . .
Relvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaits
IDQFGT
...
alelaf
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 176-372 | 2.2e-17 | 58.1 | In-house | 39-237 (250) | alignment | ||
Range on Protein: 176-372
Range on HMM: 39-237/250.0
FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAV--MPLEVTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGC
.| |. . . | ... | || | .. | |||||. .| ....|. | | .| .| . .||.. |. .. | .| | .
yinasflhgyderkafiatqgPlqat...iedfWrmvleeksgtivmLtnLkesektyhqywPv..ekaekyGdvtvsllskeefadytkrklklskakk
SNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
... . .| .| | || | .. ..|| . ... .. .|.||.|. ... . . ...| | |. . . ||..| . |. .|.
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf
VHRS
|..
vyei
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 176-388 | 1.1e-16 | 55.8 | In-house | 78-294 (319) | alignment | ||
Range on Protein: 176-388
Range on HMM: 78-294/319.0
FICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIA---VMPLEVTLQQILPllSGTYSTYGKMFV--NNKKVESAVGMTEYCLEIFP
.| |. | . .. | || | . | |||||. .| . ||. | .|.| |... | . .. .||.. | .... . . . . .|..
yinasfidgyqerekfiatqaP...lentiedfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkks
DGCSNsLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
. . .. .| .. | | |.. .... | .. | .| || || ..|. .. .|.. .. .| ||. | .|.. .|
sevet.RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq
FGTVHRSMACWFKNNSTNEEVQR
. .. . . . .|. |||
Ykfiyealleaveagdteievqd
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 176-383 | 2e-14 | 48.5 | In-house | 78-294 (325) | alignment | ||
Range on Protein: 176-383
Range on HMM: 78-294/325.0
FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESiASVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG
.| |. . ... .|.| .. | |.||.. . .|||. . |. . | | |.| . |. . .| |..
yinasylrddkkkdvflaaqaPltat...indlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk
CSNSLLTTVYHLHNWR----QKR--GLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDN
... ..| | ||| | ...|| .... .. | .. ..| ||.|....|..|. .| . .|. . . ||..| .|.
kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvet
IDQFGTVHRSMACWFKNNSTN
.||. .. ... . . |.
vdqyiliyealveaymsgntd
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 176-374 | 5.7e-13 | 44.0 | In-house | 55-252 (284) | alignment | ||
Range on Protein: 176-374
Range on HMM: 55-252/284.0
FICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSN
.| |. || . | || | .||||||| . ....|. . | || . ..... |. . || . .. .|. || .
yinasfitGyqrkdkyiatqGPl...dntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveeseeyvvrdielsedgkek
SL-LTTVYHLHNWRQKRGLEVVTDLVATMEKV------MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
. .|. | .. . .||.. ..|| .. . | |. |.||.|....| . . .... | |. ... || .| .|... |.
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf
VHRSMA
.. ..
iysall
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 176-373 | 1.3e-12 | 42.7 | In-house | 91-287 (319) | alignment | ||
Range on Protein: 176-373
Range on HMM: 91-287/319.0
FICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSN
.| |. .| . | .| | .||||||| . ....|. . | || . ..... |. . || . . .|. || .
yinasfvtGyqrkdkyiaaqGPl...dntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveetaeyvvrdielsedgkek
SL-LTTVYHLHNWRQKRGLEVVTDLVATMEKV------MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
| .|. | .. . .||. ..|| .. . | |. |.||.|. ..| . . .... | |. ... || .| .|... |.
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf
VHRSM
.. ..
iysal
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 177-372 | 6.5e-08 | 27.1 | In-house | 32-234 (237) | alignment | ||
Range on Protein: 177-372
Range on HMM: 32-234/237.0
ICAAKITVPD-FNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG
| |. . | .. | .| | || |||.|. || . .|. .| . | ..||.. | || | | .| .. .
inatylkgfdgtpkkyiaaqgpless...cddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkeefsdytvrslllskrl
CSNSL-LTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DN--TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
. . | |.. | .. . . |. .... . . .. | ||.| .| . . . | .. | |. . . |. .| |.. ||
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq
FGTVHRS
. .|..
yvfihqt
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 179-383 | 1.4e-09 | 32.4 | In-house | 86-303 (306) | alignment | ||
Range on Protein: 179-383
Range on HMM: 86-303/306.0
AAKIT--VPDFNRTMILTQVPdLssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLL--SGTYSTYGKMFVNNKKVESavgMTEYCLEIFPD---
| |. |.. ... | || | ..|||||. ||. .|.. . .| . .. . . . ..|||. |.| . .| ...| | .
anyikkevkgsdksyiatqgc.l..ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks...ladYilRelsvskk
-GCSNSLLTTVYHLHNWR-----QKRG--LEVVTDLVATMEKVMKV-NDNTVLMSMNGTGRAGTMLTLFTAMLQVQ---KGKEVNAKETLASLRAERCGI
... || ..| ...| |. ..|. . .|.... . .| .| || ||.. . . . ... ... ... |.|. | |.
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl
VDNIDQFGTVHRSMACWFKNNSTN
| .|. |..... . .....
vqteqqykfvykaikkyietkkkl
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 183-370 | 1.1e-23 | 77.4 | In-house | 109-302 (346) | alignment | ||
Range on Protein: 183-370
Range on HMM: 109-302/346.0
TVPDFNRTMILTQVPDLSSAPDIADFWRMIHQESIASVVIAVM--PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTT
. .|.. .|..|.|.. . . ||| ||.|| | | . | | | .. | | ||||.||.. . . || .|..|.| |.|..
vifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq
VYHLHNWRQKR----GLEVVTdLVATMEKVMKVN-DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVH
|.| |.. . | .. .. . .|. ..|. |.||| ... . |. |.. | | | | . ... .| | |. . |. ...
vhhhapwkhlqqppktlpiik.mihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 184-373 | 7.1e-10 | 33.4 | In-house | 79-272 (281) | alignment | ||
Range on Protein: 184-373
Range on HMM: 79-272/281.0
VPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPlLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTT
. .. | || | .| ...||.|. .... .|. .| . | . .||.. |.... |. . | ... ... . ..
gykgekeyiatqgPvPas...lvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveq
VyHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQV-QKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
. . .| .. . ..|. ..|.|.... |. | ||.|| ..| ... .| .. .|.. |...|.|| || .| . |. |.. .
l.aytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 187-383 | 1.5e-11 | 38.2 | In-house | 89-293 (563) | alignment | ||
Range on Protein: 187-383
Range on HMM: 89-293/563.0
FNRTMILTQVPDLSSapdIADFWRMIHQESIASVViAVMPLEVT----LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFP------DGCSNS
.. | || | . . |||||| .. | .| . |. .. | . |||.. |. .. | . |. | | . | .
kskafiatqgplkdt...fddFWrmiWeqnvaiiv.mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdte
LLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.| . || .| .. | . . ..| . | . .| .|.||.|| . | | . |.|. . || ..| .||.| .| ...|. .|
klvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda
MACWFKNNSTN
. . . . |.
lleaiaskete
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 189-370 | 9.7e-10 | 33.9 | In-house | 17-163 (174) | alignment | ||
Range on Protein: 189-370
Range on HMM: 17-163/174.0
RTMILTQVPDLssapdiadFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGtystygkmfvnnkkvesavgmteycleifpdgCSNSLLTTVYHLHNWR
. |..|.| ||.|.....| .|| . | | . . . ...| ...... .
prliagqgpla........fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylp
--Q--KRGLEVVTDLVATMEKVMKV--NDNTVLMSMNGTGRAGTMLTLFTAMLQVQkGKEVNAKETLASLRAERCGIVDNIDQFGTVH
|... ..| .|.... . .. . | ||.||. .. . . . |.| .....|| |.|.| . .|. ..
wpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 189-373 | 3.3e-07 | 24.1 | In-house | 91-275 (439) | alignment | ||
Range on Protein: 189-373
Range on HMM: 91-275/439.0
RTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEVTLqqILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTV--YHLHN
. | ||.| ||||.. .. . .| .| | | . || . | . . . .| . .. || .|
klyiatqgpkke...ttddfwrlviekktvtivmltnlvesyk..ywp..sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyia
WRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
| .| . .. . . ||. |. | ||.||...| |. |.. ..|. | . || .| .|... |. .. ..
wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 191-382 | 1.5e-14 | 48.6 | In-house | 93-286 (564) | alignment | ||
Range on Protein: 191-382
Range on HMM: 93-286/564.0
MILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLsGtYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNW
| || | |. |.|||||. .. ....|. | . ... | | |||.. |. .. | .. ... |.| . .| .|
yIAtqgP...laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsW
RQKRGLEVVTDLVATMEKVMKVNDN----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
.. | |.|.. ..|| ..| . .| .| || || ... . .... | |. .... ||..| .|.. .|. .|. .. . .|
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 191-384 | 6.7e-14 | 46.5 | In-house | 103-302 (330) | alignment | ||
Range on Protein: 191-384
Range on HMM: 103-302/330.0
MILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILPllSGTYSTYGKMFVNNKKVE--SAVGMTEYCLEIFPDGC--SNSLLTTVYH
| .| | . . |||||| . |..|. | .| | . |||.. |. .... .. . ..... ||.. .| | . .|
fiaaqGPkeet...vedfwrmiweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfh
LHNWRQKrGLEV----VTDLVATMEKVMKVNDNT-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.. | . |. . . .|.. ..|. ... .. |. |.||.||...| . . .|. . |. |.. .||. |. .| |. ... . ..
ftswPdv.GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
NNSTNE
|.
ygdtel
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 191-369 | 2.8e-06 | 22.5 | In-house | 15-145 (151) | alignment | ||
Range on Protein: 191-369
Range on HMM: 15-145/151.0
MILTQVPdlssapdIADFWRMIHQESIASVVIAVMPLEVTlqqI----LPLLSgtystygkmfvnnkkvesavgmteycleifpdgcsnsLLTTVYHLHN
..... | |||....... | ..| . | || |. . . .....
lyrsggp.......ladflellkelgiktivnlrseeerg...ycpeylpelg.....................................ievlhipild
WRQKRGLEVVTDLVATMEKVMKV-NDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkeVNAKETLASLRAERCGIVDNIDQFGTV
| . ... .|.... | ... . | || ||. |. .|. |.. |.|. .|. |.|.| .|| .
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 192-372 | 3.5e-06 | 22.3 | In-house | 31-166 (178) | alignment | ||
Range on Protein: 192-372
Range on HMM: 31-166/178.0
ILTQVPDlssapdiADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS---GtystygkmfvnnkkvesavgmteycleifpdgcsnslltTVYHLHNW-
.|.. |. ||........ | ..| .|| .. .| | |. ..
ylgslpp.......addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipip
-RQKRG-LEVVTDLVATMEKVM-KVNDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkEVNAKETLASLRAERCgIVDNIDQFGTVHRS
|| . ..|. .|... . . ... . | ||.||. .. . . ... | .. .|. |. || | .| ...
DhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 199-379 | 2.5e-11 | 39.3 | In-house | 26-227 (272) | alignment | ||
Range on Protein: 199-379
Range on HMM: 26-227/272.0
LSSAP---DIADFWRMiHQESIASVVIAVMPLEVTLQQILPLLS-------------GTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTV
.|..| ..|||||. ... | ..| . |. .. ... . .||...| . ..| .. . |.. . .... ..
rsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh
YHLHNWRQKRGL-EVVTDLVATMEKvmkvNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVN--------AKETLASLRAERCGIVDNIDQFGTVHRS
.| ..| | . .|.. . . . . . . | .| ||. |. .|.| . |. . |... ||| | |.| . .|. ...
lhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
MACWFKN
.. ....
llellrs
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 200-379 | 2.6e-12 | 42.3 | In-house | 22-175 (176) | alignment | ||
Range on Protein: 200-379
Range on HMM: 22-175/176.0
SSAP---------DIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGtYSTY-GkmfvnnkkvesavgmteycleifpdgcsnsllttVYHLHNWR-
.|.| ..|||..|.... | || . | .. . . . .. |. ..|.
gsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi..................................qylhlpwpD
-QKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFtamlQVQKGKEVNAKETLASLRAERC-GIVDNIDQFGTVHRSMACWFKN
. || . .|.. .... | . ... . | ||.||.. .. ....| ... |.|| .|. |. |.| . .| ... . ..|.
hgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellllkk
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 204-379 | 7.1e-10 | 33.3 | In-house | 76-266 (270) | alignment | ||
Range on Protein: 204-379
Range on HMM: 76-266/270.0
DIADFWRMIHQESIASVVIAVMPLEVTLQQ---ILPLLSGTYS--TYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLttVYHLHNWRQ-----KRG-
. .||||| .| ..|.. | .. | ... ..||. | . . | . | |.. .| .. |. .. ..| . . .
tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreeds
LEVVTDLVATMEKVMKVNDNT------VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
..|......| ...... . .| ||.||...| .|. ... |.|. . .. || .|. .|. .|. ...... . .
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 204-370 | 1.5e-07 | 26.7 | In-house | 21-143 (152) | alignment | ||
Range on Protein: 204-370
Range on HMM: 21-143/152.0
DIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLsgtystygkmfvnnkkvesavgmteycleifpdgcsnsllttVYHLHNWRQKRGLEVVTDLVATM
..||||||... | .| .|| . . . |. ..| . | .
tladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhgvpdlsqlllfll
EK----VMKVNDNTVLMSMNGTGRAGTMLTLFTAMlqvqkgKEVNAKETLASLRAERCGIVDNIDQFGTVH
. . . ... . | ||.||. .. . . |...|..| .|. | |.| | .| ..
lfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 250-373 | 4.4e-06 | 20.9 | In-house | 164-286 (297) | alignment | ||
Range on Protein: 250-373
Range on HMM: 164-286/297.0
VNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVvTDlVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKET
..| | | .| . . .|| | .| . . |.. |.|..| | .. .. .| . |. | ||.||. || .. .... |. ||
iknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav.ke.lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvet
LASLRAERCGIVDNIDQFGTVHRSM
. ||. | . .|. . ..
vkllrtqrafsiqtpeqyefcylav
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 259-388 | 9.5e-07 | 22.8 | In-house | 169-299 (305) | alignment | ||
Range on Protein: 259-388
Range on HMM: 169-299/305.0
VGMTEYCLEIFPDGCsNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKE-TLASLRAERC
.|| | | |. ... .| || .| .. . .. .|| .|. | ||.|... | . |. |. .. . | .| .|
akvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrn
GIVDNIDQFGTVHRSMACWFKNNSTN-EEVQR
.. .|. ||. . .|... |||..
nsiqtdaqylfvhqvilnyfrkkklldeevke
|
|||||||||
PTPc_DSPc_SM00012 | 280-373 | 3.9e-15 | 51.3 | In-house | 3-103 (105) | alignment | |||
Range on Protein: 280-373
Range on HMM: 3-103/105.0
TVYHLHNWRQKRGLEVVTDLVATMEKVMKVND------NTVLMSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNIDQFGTVHRS
..|| ..| .. | ..... ....|.|.. ..|... .| ||.||. .| ... |..|. |||. .... .|| .| | |.. .|. ..|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra
M
.
l
|
|||||||||
subfamily_DSP23_pd | Subfamily DSP23 | 291-370 | 4.7e-06 | 21.3 | In-house | 65-139 (148) | alignment | ||
Range on Protein: 291-370
Range on HMM: 65-139/148.0
RGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFtamlqVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVH
|| | ..| .|. . |. . . | ||.||||. . . | ... | |..| .| | | |. ..| |.
paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacy.....lvkerklaaaeaiaevrrlrpgsvetveqeklvr
|