Gene C17H12.3 in Caenorhabditis elegans

Synonym: CELE_C17H12.3, CELE_C17H12.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf10
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP019_AA protein Get Run
CeleP019_AA_64-342 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 55-357 1.4e-203 669.1 In-house 3-305 (305) alignment 
Range on Protein: 55-357
Range on HMM: 3-305/305.0
QLVQAHPIVEQFVQRALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQSANINETKNRYADVPCQDQNIVLVAKPPaPSDYVHANFVGCPMVPDKRFICT
   |.||||||||.||||.||.|||.|||..||||||||||.||||||||.|..|||||.|||||||..|...||. ||||.|||.|||||.|.|||||.
appqthpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrfica

QGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVSGTKPMDRDAEIQITTLQVSF-GDQKMSVRHLHWSDWPDR
|||||.|.|.||||..|.|||||||||||.|.||.|||||||.|.|||.|.|.|||||||||.|||.||||||||.|.... ||||||||||.|..||||
qgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdr

GVPPCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDKYAALL
|||||||||||||||.|||.|||||||||||||||||||||||||.|||||.|||||.|||.||||||.|||.|.|||.||||||||||||||.||||||
gvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaall

NPDN
...|
taen
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 62-369 6.9e-112 368.4 In-house 2-306 (307) alignment 
Range on Protein: 62-369
Range on HMM: 2-306/307.0
IVEQFVQRALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQsanineTKNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCPMVPdKRFICTQGPLDHT
.|. .|||.|| ||..|.||||..||.|   .| .||.||.       |||| ||.|||.. ..|  . . |||.|||..|  . | |.|||.||||. |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsant......dknryqdvkcqdkgrivvkfdglasdyihanylgiaikp.kkficaqgplent

VDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKK---EVKGGIVVENVSGTKPMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPC
. .|| |..|.||| ..||||.||..| || |||||  |.|.   |    | |.|.   |    .  |..|||.| ....  ...|| |..|||||||. 
qysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqi

KLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDKYAAL-LNPDN
.||...||.|||. . |.|||||||.||.|||||| .. ... . . |  | .||. ||.|| |.|||..||||.|||.|.||||.||. |. | |  . 
nltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltkny

VAKYTKFVKDYN
  ||.|.. |||
eekyakwlddyn
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 62-346 1.1e-57 190.3 In-house 5-277 (288) alignment 
Range on Protein: 62-346
Range on HMM: 5-277/288.0
IVEQFVQRALDYGVEKLRDEFRQMAKYTRPDMTQNaFNAnqsaniNETKNRYADVPCQDQNIVLVAkpPAPSDYVHANFVGCPMVpDKRFICTQGPLDHT
..  .... |. .|| |  |.|.  . .  |. .. | |      | |..|| ..|. |   | .     |  |..|| | .    ..|.||.| ||. |
vinawirlvlqiaveglkkeyrdspneasidiids.fia......nptrdryenlprcditrvkls..ddpdfyiaanvvssaky.krrlicaqaPlngt

VDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGivvENVSGTKPMDRDAEIQITTLQVS-FGDQKMSVRHLHWSDWPDRGVPPCKL
.. .| |.... || |||||. .| || | |.|.|. .|||  ..      .|   |  | |  .....|..|  |..|. |..||. .|.| |||   |
ieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenyl

TSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEK-YK
. | ||  ..  . |||||.|||.|||||.. |  .|| .  . .   .. |...||..|  .||| |||||.||..|...| | ||
splrllevlkslqkPivvhssaGvGrtgtlililialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvleelllkkyk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 63-344 2.4e-82 271.1 In-house 9-290 (305) alignment 
Range on Protein: 63-344
Range on HMM: 9-290/305.0
VEQFVQRALDYGVEKLRDEFRQMAKYTRPDMTQnAFNANQsaniNETKNRYADVPCQDQNIVLVaKPPAPSDYVHANFVGCPMVPdKRFICTQGPLDHTV
. .||.|.|. | . || ||  | ..   .  . ||   |    .. |||| || | |.| | . ..| | .|.|||.|  |  | ||||||| ||..| 
ilkfvkrtlekgpaglraefvamkrfndfekmk.afkeaq....eagknrykdvgcldnnrvkl.egpwpheyihanyvstptnp.krfictqaplektc

DDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVK---GGIVVE-NVSGTKPMDR--DAEIQITTLQVS-FGDQKMSVRHLHWSDWPDRGV
 |||.| .|.|||.| |||. .| |  ||..|..   ... | .     |.|  . |.|  . .  .|... | | .   | ..  | | || |||||||
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PPCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEK
|.  |. ||||   | |. ||||||||||||||..| .||||... . ..      ... .|.||  ||||| |||..|.|.||||..|
paadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 63-341 4.4e-63 207.6 In-house 14-283 (290) alignment 
Range on Protein: 63-341
Range on HMM: 14-283/290.0
VEQFVQRALDYGVEKLRDEFRQMAK-Y-TRPDMTQNAFNANQsaniNETKNRYADVPCQDQNIVLVaKPPAPSDYVHANFVGCPmvpDKRFICTQGPLDH
 |.|   . . .|..|  |. .  | |     . .. |..|     . .|||| ||.|.|.  |.. |   . ||||||.|      .  || |||.|  
fekfasdvvkknvdelakeyleklkpylpvqylerkifdknt....efkknrykdvvcndktrvil.kdGydGdyvhanyvkGl...kamfiltqGalkd

TVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVkGGIVvenVSGTKPMDRDAEIQITTLQVSFGDQ--KMSVRHLHWSDWPDRGVPPC
|| |.| |..|.||  |||||. || || ||.||.|   ||     | |    |  ..  |.||.|.  || |   |.  .  ..||.   |||. |.  
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf.Geit...vlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals

KLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMpDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
.|. | .| ..|    |.|||||||||||||.||||  |. . . |.  .. |||..||. |. |.| |.||| . ...|.. 
tlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldll.dlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 63-343 7.5e-52 170.8 In-house 14-292 (310) alignment 
Range on Protein: 63-343
Range on HMM: 14-292/310.0
VEQFVQRALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQsanineTKNRYADVPCQDQNIV-LVAKPPAPSDYVHANFVGCPMVPdKRFICTQGPLDHT
.|.|.  .   |.| |  ..|..     . .| .|.. .        ||||.|| |.|.  | |        ||.|||.|    .  . |||.||||.||
lenfiiateklgieglvkqyrkldakqdssltyeaykkym......hknrysdvvcldtsrvklkidksryedyihanyvktnylr.stficsqgplqht

VDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlAMGeKKEVKGGIVVENVSGTKPMDRDAEIQITTL--QVSFGDQK-----MSVRHLHWSDWPDRG
. ||| || |.. | |..|||. | |. ||  ||| ..|   |  | | | |.| .       .. .| .  .|   .|      . |  ..| .|||||
iidfwrmifqeraesilllckvgeegrpkcvgywp.slg.vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrg

VPP--CKLTSLELLSAVRgsRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
||   |.     ||. ||    | |||||||..|....||... .... . ..   . ...  |. .||  |||..|||.|.||.. .   
vpdekchtvpqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkv.daeevktellksraiciqtelqyliidrvriifarg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 64-342 2e-54 179.8 In-house 8-281 (318) alignment 
Range on Protein: 64-342
Range on HMM: 8-281/318.0
EQFVQRALDYGVEKLRDEFRQMAKYtrpDMTQNAFNAnqSANINETKNRYADVPCQDQNIVLVAKP--PAPSDYVHANFVGCPMvPDKRFICTQGPLDHT
|. |.|    |  .|  |. ....    . |  ....    ..|..|||||..   |.  |.. .      |||. ||..   .  .| .| .|.|| .|
eshvrrlresGelllseeyerlsrs...eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpet

VDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamGEKKEVKGGIVVENVSGTKpMDrDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLT
..||| |. .|.   |||| .. | || |...|||   ... .  | .|||  . .. .. |  ..  ... .  ...  ||  |. .|||.|||    .
ieDfWrmvWeqnsavivmltqeeergkakvhryWP...skgsrsygklvvelkeeve.ls.dyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgas

SLELLSAVRGSR-----VPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
 |.|.  |.         |||||||||.||||. .|.. .||||....    . . || ||.||   .||. || .|. |.|..  
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD.vfqtvkqlreqrnlmvqtedqyefiydvlleala
0040438 (Phosphotyrosine protein) phosphatases II 65-368 2.3e-79 262.3 In-house 7-311 (317) alignment 
Range on Protein: 65-368
Range on HMM: 7-311/317.0
QFVQRALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQSaninetKNRYADVPCQDQNIVLVAKPPA--PSDYVHANFVGCPMVPDKrFICTQGPLDHTV
..... |  .. .|..||... ... ....  .. .|..      |||| |... |.. | .  ..   .|||..|..| .|  ..| ||.|||||..||
lalldllksdftalleefedllslkldtysvaelpenkd......knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntv

DDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLamgEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVSF--GDQKMSVRHLHWSDWPDRGVPPCKL
.|||.|. .|.|. ||||... | |. ||||||||   ... . |...|...| ..    .|.|...||.|.   ....  |.|.|. .||| ||||   
edFwrmvweqgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

TSLELLSAVRGS----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKqCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE--------KYKDK
. |..|.||| .      |..||||||.|||||..|....||.. ... .. ... || || ||....|| .|| ......|.|..         ..| |
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk

YAALLNPDNVAKYTKFVKDY
.  ||.|. . ...  .|..
llklliplalddvklkekel
0051299 (Phosphotyrosine protein) phosphatases II 65-341 1.6e-76 252.8 In-house 12-286 (288) alignment 
Range on Protein: 65-341
Range on HMM: 12-286/288.0
QFVQRALDYGVEKLRDEFRQMAKYTRPdmtqnAFNANQSANINETKNRYADVPCQDQNIVLVAKPPA--PSDYVHANFVGCPMVPDKrFICTQGPLDHTV
..|.. |  |. .|..||... ... .           .   | .|||| |... |.. | .  ..   .|||..|... ..  . | ||.|||||..||
klvlkllangltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntv

DDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLamgEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVS------FGDQKMSVRHLHWSDWPDRGVP
.|||.|. .|.|. ||||.|..| |. ||||||||   ..... | |.|...| ..    .... ..||.|.      .....  |.|.|. .||| |||
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl...ggsltygditvtllseev....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

PCKLTSLELLSAVRGS----RVPIVVHCSAGIGRTGTIVAIEYILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
.     |..| .|| .      |.|||||||.|||||..|....||.. .. ... ....|| || || ...|| .||.......| |.
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 65-341 1.3e-39 130.9 In-house 9-278 (287) alignment 
Range on Protein: 65-341
Range on HMM: 9-278/287.0
QFVQRALDYGVEKLRDEFRQMAK-YTRPDMTQNAFnanqsANINETKNRYADVPCQDQNIVLVAkpPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVD
.||..  . | |  .. |  . .   |.|    .      |. |. |||....  .|.. ||.       ||. | |.      .|.|| ...|. .|. 
efvakghakgnegfknqftvleqvtqredevthni.....asqnkdknRltqilvpdnyrvllk..gehpdyinavfidg.ykekkafiiaesPmfntar

DFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGekkEVKGGIVVENVSGTkPMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSL
.|| .| ...|. |||||.  |. . .| ||||        | |   .| .. .  ..   | ..   . .  ..| .|.  .  .|...|  ... |.|
nfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

ELLSA-----VRGSRVPIVVHCSAGIGRTGTIVAIEYILERiAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
 ..        . .. .||||||...||... .|..  ... ...     . ...|| | |.  |.||  || .|  ..|.| 
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink.ckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_PTPRN_pd Subfamily PTPRN 65-334 1.5e-34 114.1 In-house 19-285 (297) alignment 
Range on Protein: 65-334
Range on HMM: 19-285/297.0
QFVQRALDyGVEKLRDEFRQMAKYTRPDMTQNAFNANQSANinetKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMVPDKRFICTQGPLDHTV
....  |    ..|. |.  ...|   . |... .|.. ..    |||...|   |...| . .      |||. | ..         .| ||||| .||
syledhlk.nkdrlekewealcayeaepstkevakaeknvk....knrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastv

DDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamGEKKEVKGGIVVENVSGTKPMDrDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTS
 ||| |. .| |  ||.|..  |.|  .|..|||    | .|| .   |. ||     | |  ..   |.    ..  .|  .|.  ||..|||.   . 
adfwqmvweqGvvvivnltrleeegvkqckrywp...deGsevyhiyevhlvsehiwcd.dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksl

LELLS----AVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIH
||.      . ||   |||||||.| ||||. ..|. .|.|..   .   .   .. |||||.  ..|  |. .. 
lefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 66-340 1.2e-54 180.3 In-house 11-278 (288) alignment 
Range on Protein: 66-340
Range on HMM: 11-278/288.0
FVQRALDYGVEKLRDEFRQMakytrPDMTQNAFNANQSANINETKNRYADVPCQDQNIVLVAK--PPAPSDYVHANFVGCPmVPDKRFICTQGPLDHTVD
 |...   . . . .|....     . . ..  .   .   |..|||| ..   |.. | . |    | .||. |...      .|..|.||||| .||.
kvakksarnrtgfseeynsL.....aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge.kkkkkyiatqgPladtvn

DFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlaMGEKKEVKGGIVVENVSgTKPMDrdaEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSL
||| .. ..|.. |||| . .| || || .|||   ..|..  | . |. |. .| ..   ..   .| .    ... . ....  ||| |||  |   |
dfWelvyenktstivmltelveggktkCeeYWP..dadkpknyGsvtvtlve.skele...dfvlrklllekkkteleitqyqylaWpdhgvPeskapll

ELLSAVRGS----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNY
|||. |  .      ||.||||||.||||| .|.. ..... |...   . . |. || |||  .||  || .|..|.|. 
ellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiD.vagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 66-342 3.7e-44 145.7 In-house 10-284 (290) alignment 
Range on Protein: 66-342
Range on HMM: 10-284/290.0
FVQRALDYGVEKLRDEFRQMAKYTRPDMTQnafnaNQSANINETKNRYADVPCQDQNIVLVAKPPAPSD----YVHANFVGCpMVPDKRFICTQGPLDHT
||.     | |. |..| .. .  ..  ..      . .. |...||.|..  .|.| . . . .   |    |..| ..      .|..| ||||. .|
fvanghakgnegfrnqfkmldsgesehtvt.....vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsnt

VDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAmgEKKEvKGGIVVEnVSGTKPMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLT
. ||| .|.|.||  ||||.. || || || |||| .  . |.  | . .. ..  . ...  |...   . . ...| || ... . |.. |  ... |
lvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka.ygefsik.llneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

SLELLSAV-----RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
.| ... .     .  . .||||||...||... .|..  ...   . .   . ...||.| |.  |.||  || .|....|.|. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi.dvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
0043336 (Phosphotyrosine protein) phosphatases II 67-341 4.8e-71 234.8 In-house 11-277 (278) alignment 
Range on Protein: 67-341
Range on HMM: 11-277/278.0
VQRALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQSaninetKNRYADVPCQDQNIVLVAKPPAP--SDYVHANFVGCPMVPDKrFICTQGPLDHTVDD
... |  .  .|. || .. ... ....  .. .|..      |||| |... |.. | .   .    |||..|..| .. ||.| ||.|||||..||.|
llelllnlktllllefeellsfkldtysiallpenkd......knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetved

FWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamgEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVS--FGDQKMSVRHLHWSDWPDRGVPPCKLTS
||.|. ...|. ||||..  | |. |||||||    .. .. |...|.... ..    .. . ..|| |.    ...  |.|.|. .||| |||.   . 
FwrmvwelgvttivmLtelvelgrvkcaqYwp....ggsltygdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll

LELLSAVRG----SRVPIVVHCSAGIGRTGTIVAIEYILERIaENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
|..| |||     |  |..||||||.|||||..|....||.. |. ....... || || ||. ..||..|| ......| |.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleql.ekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 67-340 4.2e-52 172.2 In-house 14-282 (319) alignment 
Range on Protein: 67-340
Range on HMM: 14-282/319.0
VQRALDYGVEKLRDEFRQMAKyTRPDmtqnAFNaNQSANINETKNRYADVP-CQDQNIVLVAKPP-APSDYVHANFVGCpMVPDKRFICTQGPLDHTVDD
...  . |  .|. ||... . . .|     |. . | ..|..|||| ..  ..   .|| . .    |||. |.|.       ..|| ||.||..|..|
lkalastgetllekefkllke.avnd....tfd.saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentied

FWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLamgEKKEVKGGIVVENVSGtkpmDRDAEIQITTLQVSFGDQKM---SVRHLHWSDWPDRGVPPCKLT
|| |. ....  .|||.|  | .| |. .|||    |. |. | ..|.  .     .. ... |  |..    ...   .| | .. .||| .||   ..
fWrmvWeeessivvmltklveklkvklkkywpe...enfeeyGrlivtleee....eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

SLELLSAVRGSR-----VPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNY
 |.||  .| ||      |||||||||.||||| .... .|||. |.     .   |. || ||   .|.  || .|. ..|..
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPN23_pd Subfamily PTPN23 68-349 1.1e-50 167.1 In-house 7-287 (288) alignment 
Range on Protein: 68-349
Range on HMM: 7-287/288.0
QRALDYGVEKLRDEFRQMAKYTRPDmtqNAFNANQSANINETKNRYADVPCQDQNIVLVAkpPAPSDYVHANFVG--CPMVPDkrFICTQGPLDHTVDDF
||.   |. .|  .|... ..   .   .  ..   |... .|||. |.   |.| | .       ||. | ||    |. ||  ||.||.||. |. ||
qrkmldgktaldkkfkeleqkqdke...arkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPd..fiatqaPlqstlnDF

WWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGgIVVeNVSGTKPMDRDAEIQItTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLEL
| |...||.. |||| .  |.|| |...||| . || .. .  . |  .. .. ..   | .. .|..   |.. ||.||..  ||. |||    | |..
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.lsv.tlksvretethvervl.kletldadavksvshlqltsWpelGvPasPetllqf

LSAVRG--------SRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYfLEKYKDKY
| .|.         |..|.|||||||.||||..  .  ... . ...  . ....|. || || ...|.  |.     ..|..  ... ||.
ldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea.arrvldkr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 68-351 6.1e-24 79.2 In-house 14-289 (303) alignment 
Range on Protein: 68-351
Range on HMM: 14-289/303.0
QRALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQsanineTKNRYADVPCQDQNIVLVAKppapSDYVHANFVGcpMVPDKRFICTQGPLDHTVDDFWW
.| ||   .   .|| ... |  |....| |  |        |||..|| | |.  | ..     | |.||...   .  .|. | || || ||  ||| 
krtldedaniavnefekvvsylppsvsknqfvknm......dknrfvdvicldhskvklsd....ssyihasyle..ldsskkailtqlplshtaadfwq

MIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVsgtKPMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPC---KL--TS
||..|||  ...|    |  |.     .|      |  .  | | .    | ..     ..  | || || |  .   |. .||   .|     |.    
miieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgef...krvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqi

LELLSAVR--GSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDKYAA
 .| | .|      | |    .| ||.||.  .|     . ... .  .   .. .|. | ...|   |. ... .. .. |..   | | 
wqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklai
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 69-341 4.8e-57 188.5 In-house 20-290 (298) alignment 
Range on Protein: 69-341
Range on HMM: 20-290/298.0
RALDYGVEKLRDEFRQMAKYTRpDMTQNAFNANQSANiNETKNRYADVPCQDQNIVLVAK--PPAPSDYVHANFVGCPMVPDkRFICTQGPLDHTVDDFW
   . .. .. .||... . .  .. ..  .. .. . |. ||||||.   |.  |.. |      |||. | |.      .  || ||.|| .|| |||
vkkkkkltgyalefqrlnsvss.eieeeekevarkpe.nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFW

WMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamGEKKEVKGGIVVENVSgtkpMDRDAEIQITTLQVSFGD--QKMSVRHLHWSDWPDRGVPPCKLTSLE
 |....... |||| .. |..| |. .|||    |.||  | | |.  |     .. |.. ...|.||  .  .. .||.||.. |||.|||  . . |.
rmvteedigtiVmltnleeldktkyhkywP...degketygeitvslls....keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

LLSAVRGS-----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
||. || |      .|..|.||||.||.|| .||. .|||. ...    . . || || .|. ..||  || .|. ..|...
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Ptp69D_pd Subfamily Ptp69D 69-342 1.9e-50 166.7 In-house 18-287 (307) alignment 
Range on Protein: 69-342
Range on HMM: 18-287/307.0
RALDYGVEKlrdEFRQMAKYtrpDMTQNAFNANQsaNINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFW
|  |.|..|   |.... .     . ... ....  . |  |||| |.   |.. | ..| .  . |||. |.|.       |.||. |.|.. |..|||
rdtdfglak...eyekLear...eidkstkvsek..kenalknRyedikafDktRvkLkkingkedsdYinasfikg.ykekkkfiaaqdPveatigDfW

WMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAmgeKKEVKGGIVVENVSGTKPMDR-DAEIQITTLQ--VSFGDQKMSVRHLHWSDWPDRGVPPCKLTSL
 || .|.|. |||| .  |. . |||.|||     ..   | |.|. ||  |  |    |..... .  ..  ...  |   |.  |.|  || .  . |
RmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

ELLSAV----RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKqCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
.|.. |    . .| ||||||||| ||.|..||.. .|... ... .  . . || || ||   .|   || ...| .|.|  
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 70-370 1.2e-48 161.1 In-house 28-316 (319) alignment 
Range on Protein: 70-370
Range on HMM: 28-316/319.0
ALDYGVEKLRDEFRQMAKYTRPDMTQNAFNANQsaniNETKNRYADVPCQDQNIVLVAKP--PAPSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWW
 .|  . ||. |||...| . .  .|.  | .|    |  |||. ..   |.|.| . .      |||. | ||     .|| .| .||||| |..||| 
dfdddltklevefrracklgvnladqtfanldq....nkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdk.yiaaqGPldntladfWr

MIVQQKVEQIVMLCktietgKYKCAQYWPLAMGEkKEVKGGIVVENVSGTKPmdrdaeIQITTLQVSF-G--DQKMSVRHLHWSDWPDRGVPPCKLTSLE
|| ....  ||.|       | ||.||||| . . || .. . |. |  |.         .  ...|  |   .. ...  |.  ||| |||      . 
miweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveetae......yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmr

LLSAV------RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDkyaaLLNPDNV
|.  |         | .||||||||.||||. .... .|.|. |.||   . ..|. ||.||   .|  .|| .|.  .|. .|  . |    .  ||  
lvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd....vampdfp

AKYTKFVKDYNF
| . .  ....|
ayleelsnksdf
subfamily_PTPN6_pd Subfamily PTPN6 72-343 5.9e-56 184.7 In-house 22-299 (306) alignment 
Range on Protein: 72-343
Range on HMM: 22-299/306.0
DYGVEKLRDEFRQMAKYTrpdmTQNAFNAN-QSANINETKNRYADVPCQDQNIVLVAKPPAPS-DYVHANFVG-CPMVPDKRFICTQGPLDHTVDDFWWM
... . . .|| .. .      ... .. .  . . |..||||  .   |.. | ...|  |  ||. ||..       ||..| ||| |..|| ||| |
slekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IVQQKVEQIVMLCKTIETGKYKCAQYWPLAMgEKKEvKGGIVVENVSGTKpMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSA
..|.. . |||. | .| || |||.||| .  ||.|  | | |.||| .. ...    ...  ........ .|...|. .||| |||  . . |..|. 
vwqensrvivmttkevErgkekCarYWPdee.ekee.yGkisvtnvseks.ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VRGS--------RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCP--PMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
|.            |||||||||||||||.. |. .|. | ...      . .||||.|.||   .||. || ...... .|  .
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN9_pd Subfamily PTPN9 72-271 1.2e-39 131.1 In-house 12-204 (297) alignment 
Range on Protein: 72-271
Range on HMM: 12-204/297.0
DYGVEKLRDEFRQMAKytrpDMTQNAFNANqSANINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMI
. | . |. |. .. .      ..  |.|    . | .||||.|| | |.  | .|| .    |||..||||       | || |||||..||.||| |.
ekgkrGlskeyaeirn....epveGtflas.klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmv

VQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVkGGIVVENVSGTKpmDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAV
 .|.|  |||  ...|.|. ||.|||||  .. .|  | . |.||.  .   .| .... ... .  ... .| |     ||| |||    . |..|..|
WeqevlvivmttrvvergrlkcgqyWpleeessaef.gdlsvsnvevee..eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekv

RG
| 
re
0045450 (Phosphotyrosine protein) phosphatases II 73-343 1e-73 244.1 In-house 24-306 (307) alignment 
Range on Protein: 73-343
Range on HMM: 24-306/307.0
YGVEKLRDEFRQMAKYTRPDmtqNAFNANQSANINETKNRYADVPCQDQNIVLVAKPP---APSDYVHANFVGCPMV-------PDKRFICTQGPLDHTV
 ....|. ||... ..| ..   .      .   | .|||| |... |.. | .  ..    .|||..|..| .|..        ...||.|||||..||
dfltgllkefekllsvtvfl...lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

DDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAmGEKKEVKGgIVVENVSGTKpmdrDAEIQITTLQVS---FGDQKMSVRHLHWSDWPDRGVPPCK
.|||.|. .|.|. ||||....| |. |||||||.  ||... .  ..|...| ..    .......|| |.   . ..   |.|.|. .||| ||||  
edFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

LTSLELLSAVRG------SRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQC--PPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
 . |... .||       .  |..||||||.|||||..|. ..|... ... .  ..... || ||.||  ..|.  || ......| ..|.
eelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
0039614 (Phosphotyrosine protein) phosphatases II 74-345 2.6e-75 248.9 In-house 30-293 (297) alignment 
Range on Protein: 74-345
Range on HMM: 30-293/297.0
GVEKLRDEFRQMAKYTRPdmtqnafNANQSANINETKNRYADVPCQDQNIVLVAKPPA---PSDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIV
.  .|. || .. ... .               | .|||| |... |.. | .  ..    .|||..|..| .. . ...||.|||||..||.|||.|. 
sktllllefeellslkpd.......ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

QQKVEQIVMLCKTIETGKyKCAQYWPLAMGekkeVKGGIVVENVSGTKpmdrDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR
.|.|. ||||.|..| |. |||||||  .|    . |...|.... ..    .. . ..|| |. ...   |.|... .||| ||||.  . ||.| .||
eqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkveh....ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvr

G------SRVPIVVHCSAGIGRTGTIVAIEYILERIaENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
       .  |..||||||.|||||..|. ..||.. | .... ... || || || ...||. || ......| ... |.
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleql.ekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_PTPN12_pd Subfamily PTPN12 74-345 2.4e-63 208.7 In-house 6-281 (290) alignment 
Range on Protein: 74-345
Range on HMM: 6-281/290.0
GVEKLRDEFRQMAKYTRPDMTQNAFNANQS-ANINETKNRYADVPCQDQN-IVLVAKPPAP-SDYVHANFVGCPMVpDKRFICTQGPLDHTVDDFWWMIV
| |..  || .. | ..   .......... .. | .|||| |.   |.. ..|  .   . |||. |||.  .   ....| .|||| .|.|||| || 
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiw

QQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKkEVKGGIVVENVSgTKPMDRDaeIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR
...|| .||.|. .| || ||..|||  ..|.    | . |.. .  | .| |  . | ||.| . ... .|. .|. .|||.|||  . . |||...||
eknveivvmaCrevelgkkkCerYWpeegeee.lefgefevtlee.ekavddd..flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvr

GS----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQ--CPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
       .|.|||||||.||||||.||.|. | . ..|   .  . ||| .|| |||  .||  || .... ..... .. 
elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
subfamily_PTPRA_pd Subfamily PTPRA 74-343 4.6e-53 175.2 In-house 30-297 (330) alignment 
Range on Protein: 74-343
Range on HMM: 30-297/330.0
GVEKLRDEFRQMAKYtrpdMTQNAFNANqSANINETKNRYADVPCQDQNIVLVAK--PPAPSDYVHANFVGCPMVpDKRFICTQGPLDHTVDDFWWMIVQ
  ...|.||  .         |.....  | . |. |||. ..   | . | ...      |||. | |.       ..|| .|||...||.||| || .
dnklfreefnalPag....piqatlela.skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGPkeetvedfwrmiwe

QKVEQIVMLCKTIETGKYKCAQYWPLaMGEKKEVKGGIVVENVSGTKPM-DRDAEIQiTTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR
||   |||| .  |  . |||||||   |     .  . ||..  .. .  |.  .|    . .  ...  || .|.  ||| |||      |.|| .|.
qksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

GSR----VPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
  .     |||||||||.||||| .... .|||.  ...   . . ||.|| ||.  .|||.|| .|..|.|.|.| 
klnqqsagpivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_ptpA1_pd Subfamily ptpA1 75-297 7.5e-29 95.7 In-house 20-253 (418) alignment 
Range on Protein: 75-297
Range on HMM: 20-253/418.0
VEKLRDEFRQMAKYTRPDMTQNAfnanqSANINETKNRYADVPCQDQNIVLVAK--PPAPSDYVHANFVGCPMvpDKRFICTQGPLDHTVDDFWWMIVQQ
. |...||| . .   |  | .        . | .||||...   ..  | . |      |||. ||..       |.||||||||  |. ||| |. ..
ihkikeefrlleesvgpsetseg.....dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay..pkqfictqgplpntiadfwrmvwen

KVEQIVMLCKTIETGKYKCAQYWPLAMGE--------KKEVKGGIVVENVSGTKpmDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLE
..  |||| .  |  . || .|||  .|          .|| |   || |   .  | . ||    ....|  .   . . ..  |||. .|       .
rcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviq..dpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrq

LLSAVR----------GSRVPIVVHCSAGIGRTGTIVAIEYIL
|| ..              |||.||||||.|||||...   ..
llhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_PTPRB_pd Subfamily PTPRB 76-344 7.5e-61 200.7 In-house 25-288 (293) alignment 
Range on Protein: 76-344
Range on HMM: 25-288/293.0
EKLRDEFRQMAKYTRpdmtqNAFNANQSANINETKNRYADVPCQDQNIVLV--AKPPAPSDYVHANFVGCPMVPdKRFICTQGPLDHTVDDFWWMIVQQK
 .. .|. .. .  .     .   .  ....|..|||| ..   |.. | .   |  . |||. ||..     | . || ||||| .|||||| |. ..|
lrfseeyeelkavgk.....dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekk

VEQIVMLCKTIETGKYKCAQYWPLAmgEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR
.. |||| ...| || || .|||    |.  . | | |. |. ..      .  | .|... ......||..|.  ||| |||    | |... .|| . 
ssiivmltqlvekgkvkCeeYWPad..eepvlyGdikvtlvaeee....ledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

------VPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEK
       |||||||||.||||| .|.. .|..| |.     .  .| .|| .|.. .||  ||..||...|... .|
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvd.ifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 76-339 1.2e-37 124.5 In-house 20-277 (439) alignment 
Range on Protein: 76-339
Range on HMM: 20-277/439.0
EKLRDEFRQMaKYTRPDMTQNAFNANQSanINETKNRYADVPCQDQNIVLV-AKPPAP-SDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQK
| ....| .. . |.|| . .|  | |.   ..||||| ||   |   | .   |  | | |. ||..      || .| |||| ..|.|||| .....|
eifkeifeki.nstspdyaciaslaaqe..ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkkettddfwrlviekk

VEQIVMLCKTIETGKykcaqYWPlamGEKKEVKGGIVVENVSGTK-PMDRDAEIQItTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS
. .||||.. .|. |     |||    ... . | |.|      . |      ...   .   .... .| ..|.  |||. ||      |..| |.  .
tvtivmltnlvesyk.....ywp...sdaevcygdiavrvdrnielpnyvirgfkv.fnerdttekertvlqfhyiawpdknvpaqashvldflrainsa

-----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLN
       |.|||||||.||||||.|..  ||..  ...   .  .|| ||.||   .|.  ||..|.  .|.
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkv.dikgivkvlrkqrkqmvqalcqyvfiynavle
0047943 (Phosphotyrosine protein) phosphatases II 77-341 3.3e-75 248.4 In-house 13-272 (273) alignment 
Range on Protein: 77-341
Range on HMM: 13-272/273.0
KLRDEFRQMAKYTRPDMTQNAFNANqsaniNETKNRYADVPCQDQNIVLVakPPAPSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQ
.|. ||... ... .  .. |   .     | .|||| |... |.. | .  .. .|||..|..| .. .. | ||.|||||..||.|||.|. .|.|. 
llleefelllslkplltysvallpe.....nkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrv

IVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVSF--GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG---
||||....| |. |||||||| .|| ... | . |...| ..    .. . ..||....   ...  |.|.|. .||| ||||     ||.. .||    
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

---SRVPIVVHCSAGIGRTGTIVAIEYILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
   |  |.|||||||.|||||..|....|... .. ... ....|| ||.|| ...||  ||.......|.|.
alpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_CG7180_pd Subfamily CG7180 77-343 1e-31 104.7 In-house 14-292 (296) alignment 
Range on Protein: 77-343
Range on HMM: 14-292/296.0
KLRDEFRQMAKYTRPdMTQNAFNANQSANiNETKNRYADVPCQDQNIVLVAK--PPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKV
| | |.... | |   ....   ..  .. |  |||. .|   |.| |.. |    . |||. | .|   .. .| .| |..| ..|||.|| .. ....
kfrveyklelkltpr.leigdCagglrke.nreknrdvkvvPyDynRvvLekldGeeksdYinavyvds.flkkkeyivteapkketvdefWrlvydeei

EQIVMLCKTIETGKyKCAQYWPLAMgekKEVKGGIVVENVSGTK-PMDRDAEIQITTLQVSFGDQKM-------SVRHLHWSDWPD-RGVPPCKLTSLEL
. .|.|.|| .  | .. .|||  .   ||  | |.|| |.  . .  .  ....|   |. ..|.         |.....  |.    ||    . .||
savvvLtktfdfak.mypsywpnks...keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnaliel

LSAVRG---------SRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
.  ||           . |.||..| | .|.|  .||.  || . ....   . . || || .|   ...  .| ||  |.|...| 
rrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeev.dvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
DSPc_SM00195 78-341 7.5e-79 260.1 In-house 2-262 (263) alignment 
Range on Protein: 78-341
Range on HMM: 2-262/263.0
LRDEFRQMAKYTRPD-MTQNAFNANQsanineTKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPmVPDKRFICTQGPLDHTVDDFWWMIVQQKV
|. ||... ..| |. .|......|.      .|||| .... |.. | . |..   .|||..||.. ..  ..|..|.|||||..||.|||.|....||
lkeefekleestspketteaekkknk......sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekv

EQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKgGIVVENVSGTKPMdrdAEIQITTLQVSFGD--QKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS
..||||..  | || ||..|||  .|.|....  | |..|. .|     .||...||.... .  .. .|..... .|||.|||  .   ||||.||. |
kiivmlteeeengkekcdrywpeesggketfg.kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkks

----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQcPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
     .|||||||||.|||||.|.|..||....|.|. . . ..||.||.||. ..||..|||.|....|.|.
kstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 78-341 7.5e-79 260.1 In-house 2-262 (263) alignment 
Range on Protein: 78-341
Range on HMM: 2-262/263.0
LRDEFRQMAKYTRPD-MTQNAFNANQsanineTKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPmVPDKRFICTQGPLDHTVDDFWWMIVQQKV
|. ||... ..| |. .|......|.      .|||| .... |.. | . |..   .|||..||.. ..  ..|..|.|||||..||.|||.|....||
lkeefekleestspketteaekkknk......sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekv

EQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKgGIVVENVSGTKPMdrdAEIQITTLQVSFGD--QKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS
..||||..  | || ||..|||  .|.|....  | |..|. .|     .||...||.... .  .. .|..... .|||.|||  .   ||||.||. |
kiivmlteeeengkekcdrywpeesggketfg.kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkks

----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQcPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
     .|||||||||.|||||.|.|..||....|.|. . . ..||.||.||. ..||..|||.|....|.|.
kstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 78-345 2e-76 252.4 In-house 2-278 (284) alignment 
Range on Protein: 78-345
Range on HMM: 2-278/284.0
LRDEFRQMAKYTRPDMtQNAFnaNQSANINETKNRYADVPCQDQNIVLVAKPPAP---SDYVHANFVGCPM----VPDKRFICTQGPLDHTVDDFWWMIV
|..||... ..| . .  .       .  | .|||| |... |.. | .  ..     |||..|..| ..        |.||.|||||..||.|||.|. 
leeefeellsltvkll.lsls..vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvw

QQKVEQIVMLCKTIETGKYKCAQYWPLAmgEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVSF---GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLS
.|.|. ||||....| |..||||||||   ... . |.. |...| ..    .  . ..||....   ... . |.|.|. .|||.||||     ||.| 
eqnvrvIVmltelvengrekcaqYwple..gevltygdftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

AVRGS------RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQ--CPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
.|| .        |||||||||.|||||..|....||.. ....  .......|| ||.|| ...|| .||.......|.|.. |.
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRG_pd Subfamily PTPRG 78-350 3.2e-49 162.6 In-house 21-296 (563) alignment 
Range on Protein: 78-350
Range on HMM: 21-296/563.0
LRDEFRQMAKYTRPDMTQNAFnAnqSANINETKNRYADVPCQDQNIVLVAKPPA-PS--DYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKV
.  || .. . | ..  .  . .  ... |  |||| ..   |.  | ... |   .  ||. ||..       | || ||||| .|.|||| || .|.|
fseefealqsetiskdldaeh.s..qkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidG.yqkskafiatqgplkdtfddFWrmiWeqnv

EQIVMLCKTIETGKYKCAQYWPLamgEKKEVKGGIVVENVSG-TKPMDRDAEIQITTLQVSFGDQ---KMSVRHLHWSDWPDRGVPPCKLTSLELLS---
. |||. .  | |. || .|||    .. |  | . |  ..  .. .    ...|  |..  ..|   .  ||. |...||| |||  .|  |       
aiivmitnlvergrrkcdvYWPk...desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkss

AV-RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAEnKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDKYA
|  .    |||||||||.||||| .... .|..| . ..   . ...| .| || . .||  ||...| ..|.  . | ..  |
aankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
subfamily_PTPRD_pd Subfamily PTPRD 79-341 1.6e-64 213.5 In-house 18-281 (564) alignment 
Range on Protein: 79-341
Range on HMM: 18-281/564.0
R--DEFRQMAKYTRPDMTQNAFNANQSANINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKV
.  .... . .| . .. |.    . ....|  |||||..   |.. |   | .    |||. |.|.   .  .| .| ||||| .|..||| |. .|..
kansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqns

EQIVMLCKTIETGKYKCAQYWPLAmGekKEVKGGIVVENVSGTKPmdRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS--
. |||| |. | || ||..|||   |  .|  |...|. .. ..    | ||   .|. .  .... ||. |. .|||.|||    . |.|.. || .  
stiVmltkleEkgkvkchkYWPek.g..tetygeltVtleeeeel..adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne

--RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
  . |||||||||.||||| ..|...|||| |.|.   .   || || || . .||  || .||...|.. 
pdagPivVhCSaGVGRTGtfividamlerikeektv.DiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_PTPN13_pd Subfamily PTPN13 80-339 1.7e-53 176.7 In-house 15-267 (273) alignment 
Range on Protein: 80-339
Range on HMM: 15-267/273.0
DEFRQMAKYTRPDMTQNAfnanQSaNINETKNRYADV-PCQDQNIVLVAKPPapsdYVHANFVGCPMVPDK-RFICTQGPLDHTVDDFWWMIVQQKVEQI
.||... .    | .. .    .. . |..|||| .| |...  . | .. .    |. |...  |.  |. ..| .|||| .||.||| |. .||.| |
eefkelrelkpldtcevg....kk.kenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVSGTKPMDrdAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG---SRV
.|. .  |.|| || .|||  ...|  |.. . ||..  .|  .    ..  ... |   .   | ||.. .||| |||   .  |.... ||    .. 
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldg..fvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag

PIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLN
||||||||||||.||...|. .|. |. .|.  .. ..|..||.||   .||. ||.......|.
PivvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 80-342 8.1e-46 150.9 In-house 15-270 (281) alignment 
Range on Protein: 80-342
Range on HMM: 15-270/281.0
DEFRQMAKYTRPDMTqNAFNanqsANINETKNRYADVPCQDQNIVLV-AKPP--APSDYVHANFVGCPMVpDKRFICTQGPLDHTVDDFWWMIVQQKVEQ
.|| ..      |.   .||      .|. ||||...|| |   | .  | |    .||.|||..  |..  . .| ||||   |  ||| || |..   
qefsnlpgdppsdlc.tvfn....qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmiwqentta

IVMLCKTIETGKYKCAQYWPLAMGEKKEVK-GGIVVENVSgtkpmdRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSRVP
|||||. .|| . |||.|.|       ..    .  |. .       .  .  | |..|.  .   . |  | .|||  ||      |..|  .|    |
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedst......vnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstp

IVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRD-QRAYSIQTDMQYLYIHRVMLNYFL
 |.|||||.||.||..|.|  |. |      | . ..|  ||   || |.||  ||. | .|.|.. .
pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 81-370 5.2e-47 155.7 In-house 3-280 (284) alignment 
Range on Protein: 81-370
Range on HMM: 3-280/284.0
EFRQMAKYTRPDMTQNAFNANQsaniNETKNRYADVPCQDQNIVLVAKP--PAPSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQIV
|||...| . .  .|.  | .|    |  |||. ..   |.|.| . .      |||. | |.     .|| .| |||||| |..||| || ....  ||
efrracklgvngtdqtfanldq....nkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstiv

MLCktietgKYKCAQYWPLAMGEkKEVKGGIVVENVSGTKPmdrdaeIQITTLQVSF---GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAV------
.|       | ||.||||| . . || .. . |. |. ..         .  ...|      .. ..|  |.  ||| |||      . |.  |      
llt......kdkcsqywplkivi.keerfkvkvdsveesee......yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk

RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDkyaaLLNPDNVAKYTKFVKDYN
   | .||||||||.||||. .... .|.|. |.||   . ..|. ||.||   .|  .|| .|.  .|. .|  . |    .  ||  | . .  ....
enhranivvhcsagvgrtgvyivldvlldrmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd....valpdfpayleelsnksd

F
|
f
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 81-347 3.8e-40 133.0 In-house 24-294 (325) alignment 
Range on Protein: 81-347
Range on HMM: 24-294/325.0
EFRQMAKYTRPDMTQNAFNANQSAniNETKNRYADVPCQD-QNIVLVAKPPAP-SDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKvEQIV
 | .  . . .| ..    | . .  |  |||. .|   | . .||..|  .| |||. |...    .  . |. .| || .|..|.| .... .   .|
gfahefgllpsddgiakkvamkpe..nkaknrfknvvaldksrvvletkkddpssdyinasylrd.dkkkdvflaaqaPltatindlWrlvldWr.csvv

MLCKTIETGKYKCAQYWPLAMGEKKEVkGGIVVENVSGTKPmDRDAEIQITTLQVSFGDqKMSVRHLHWSDWPDRGVP--PCKLTSL-ELLSAV----RG
..   ...|| .||.|||  ||. |.  ||. |. ..  .        ..   ||. |.  .||. ...  |.| ||.  |. | |. .|. ||    . 
vvlneldlgkdrcavywpkemgksktf.Gglevklrtieei.sdyvhrvldvkqvkkGe.trsvkqfqlqswddmGvqkrpatlisilqlvkavservta

---SRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKD
   .  ||.||||||.||||. ...  .|... |. .   . . || || .|   ..|  ||  |.  . ....    |
ntkastpilvhcsaGvGrtGvfislysalakvieesrvd.ifgfvkklrkdrpsmvetvdqyiliyealveaymsgntd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 82-341 1.4e-39 130.7 In-house 12-266 (283) alignment 
Range on Protein: 82-341
Range on HMM: 12-266/283.0
FRQMAKYTRPDMTQNAfnanQSANINETKNRYADVPCQDQNIVLVAkpPAPSDYVHANFVG--CPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVM
. .. . . ||.  .     .||. |..|||. ..  .||..| .   . . ||. | |.        ||..| .|.|||.|| ||| |. ..|.  |||
revlkrlsvpdldadi....asadenkrknrnqeivpadqwrvelk..sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LCKTIETGKYKCAQYWPLaMGEKKEVKGGIVVENVSGTKPMdrdaEIQITTLQVS-FGDQKMSVRHLHWSDWPDRGVPPcKLTSL---EL-LSAVR-GSR
| |  |  . ||.||||   | ..  .  . ...  . . .     |.  .|.|.    ... . |    || . |  .  . ||   ..  |  .   .
ltklqedlrikCsqyWPk.rGsedyGeftvtlrkettsnsf....iikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskk

VPIVVHCSAGIGRTGTIVAIEYILERIAeNKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
 |||||||.|||||.. .|.   .. .   .    ..  || .| ||   .||  ||  .| ..|.  
gPivvhCstgiGrtavfiaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 84-184 3.5e-08 27.4 In-house 20-120 (347) alignment 
Range on Protein: 84-184
Range on HMM: 20-120/347.0
QMAKYTRPDMTQNAFNANQSaninetKNRYADVPCQDQNIVLV-------AKPPAPSDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKVEQ
..|.|. ...| . .. . |      |||  ||  .|.  |..       ..   .  |. |  .      .| .| || || .|| ||| |.   || |
nlanyspskftsveweksls......knrskdvklidatrvvlspeksknsraddvetyinashikfdn.askeyiltqyplpdtvrdfwkmvsvtkvtq

IVMLCKTI
.| . . |
vvtifepi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 85-343 3.2e-43 142.7 In-house 19-272 (285) alignment 
Range on Protein: 85-343
Range on HMM: 19-272/285.0
MAKYTRPDMTQNAFNANQsanineTKNRYADVPCQDQNIVLVAKppAPSDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTI
.  |  |. |  |..||         |||||| | ..  |.. .     ||.||...  |   .  .| |||||  |. ||| || |.|.  ..|||  .
ikgymppnctytayeanp......dlnryadvrcieetrvvlkn..hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlf

ETGKYKCAQYWPLAMGEKkeVKGGIVVENVSGTKPMDRDAEIqITTLQVSF----GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAV---RGSRVPIV
| |  ||| |.|  .||   || |     ..  |       | . .| |        . . . |..   |||.  |      .||   |        ||.
eggvekcalyypeklgev..vkfgkyeitlteckeeaiagti.lnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpic

VHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
||||||.||| |.| |.|   || || .   | |.|. .|  |  ..|. ||.|... |...||. 
vhcsagvgrtatfvgidyatirimenpni.emldivremramrfqavqshmqflflyvvlmeyfig
subfamily_PTPN3_pd Subfamily PTPN3 89-341 1.7e-53 176.4 In-house 27-275 (280) alignment 
Range on Protein: 89-341
Range on HMM: 27-275/280.0
TRPDMTQNAfnANQSANIneTKNRYADVPCQDQNIVLVAKPPApsDYVHANFVGCPMVP---DKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIE
 .|... .|  |....|.  .|||| |.   |.  | . . ..  ||. ||.|   .      .|.| |||||..|. ||| |. .||.. ||||  ..|
kkpglaisa..arkpenl..sknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

TGKYKCAQYWPLAMGEKKEVKGGIVVENVsgtkPMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR----VPIVVHCS
 |. || ||||    | .  .  ...|.       ..   ..  .|. .  ... .. .| . .||| |||  .   ||... ||  |     |.|||||
rGrvkChqyWPetedeleygefsvkceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCs

AGIGRTGTIVAIEYILERIAENKQCPPmPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
||||||| ....|  |  | ....  | .|.|. .|||||  .||  || ..   .|. .
aGigrtGvlilletalalieaaepvyp.ldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 89-342 2.6e-33 110.0 In-house 30-237 (392) alignment 
Range on Protein: 89-342
Range on HMM: 30-237/392.0
TRPDMTQNAFnanQSANINETKNRYADVPCQD-QNIVL-VAKPPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIET
  ||. ...       .||  |||| ..   | . ..| |    . |||. | .. . .  .| .|..|||   ..|||| |. |..|  |.|. |  | 
pgpdiypqtv...aqkeinlkknryknilpydsarvkleviddipdsdylnasyips.fdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkeg

GkykcaqywplamgekkevkggivvenvsgtkpmdrdaeiqittlqvsFGDQKMSVRHLHWSDWPDRGVPPCKLTSLEL---LSAVRGSRV-PIVVHCSA
                                                 ||.. .|   |...|||..||    . |..   ..|  |.   |...||||
d...............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GIGRTGTIVAIEYILERIAEnKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
|.|||| ...|. .. .  .  .   . ..|  .| .| | .||. || .|.  .|. .|
gvgrtgvvisidsvvahakk.trmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 90-189 1.4e-11 38.5 In-house 84-177 (244) alignment 
Range on Protein: 90-189
Range on HMM: 84-177/244.0
RPDMTQNAFNANQSAninetKNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKY
 | . ..||| |.|      ||| .     | | | ..|      |. | |||| .     .| || ||  |  ||| |.....|. .|.|    |  .|
dpsvmkdafnpnnsw.....knregaglpfdfnrvplskgsmgntyinasfvgc.lgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedey
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 91-342 6.5e-48 158.2 In-house 31-278 (315) alignment 
Range on Protein: 91-342
Range on HMM: 31-278/315.0
PDMTQNAFnanQSANINETKNRYAD-VPCQDQNIVL-VAKPPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGK
||. ..        .|| .|||| . .| . . ..| |      |||. | ..   .  || .|..||||. .||||| |..|.||  |||. |  |  |
Pdiyrqrv...aretinfkknryknilPldsarvkleviddsPdsdyinasyiks.vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdk

YKCAQYWPLAMGEKKEVkGGIVVENVSgtkpMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR----VPIVVHCSAGI
 ||.||||   ..  |  | | || .|    .. |..  .  | .  ....  |   .. .|||.||.    . |.|. .|....     ...||||||.
ikcrqywPdrkadsvef.Gsikvells....leadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGv

GRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
|||| ...|. ....|....    . ..|| ||..| | .||. .| .|. ..|...|
GrtGvvisidevvaqikrtrsv.dvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN14_pd Subfamily PTPN14 91-341 2.2e-42 140.1 In-house 33-296 (300) alignment 
Range on Protein: 91-341
Range on HMM: 33-296/300.0
PDMTQNAFNANQSANINETKNRYADV-PCQDQNIVLVAKPPAPSDYVHANFVGCPMVPDK-RFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGK
| . ..|     . . |. |||. || | .|. . |..   . ..|. |  .  ..   .  .| .||||..|| ||| |. .|.|. |||| ...| ||
pkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

YKCAQYWPLAMGEKKEVKGGIVVENVSGTKPMDRDAEIQITtLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG-------------SRVP
 |. .|.|    .||.|. |        ..  |. . .... |.     .. .| || . ||||.|||.   . |. |  |.              |. |
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglk.lkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

IVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
..||||||.|||| ..  . ... .  |..   ..  .. || || . .||  || ....|...|.
vlvhCsaGvGrtGvlilsdlliatlehneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 93-342 3.6e-57 188.6 In-house 29-277 (281) alignment 
Range on Protein: 93-342
Range on HMM: 29-277/281.0
MTQNAfNANQsANINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYK
. . | .| . |. | .|||| ..   |.  | |..      .||. ||||   .  .|..| ||||. .....||.|...|||..|||. . ||.|| |
vdnta.task.adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklk

CAQYWPlamGEKKEVKGGIVVenVSGTKPMDRDAEIQiTTLQV-SFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAV-----RGSRVPIVVHCSAGI
| .|||    ...|.| | |.  |. |.  ..   |.  ....   . .. .|..|..  ||| |||      ||  ..|     . . .|.|.|||||.
ChrYWP...ddnselkygdvt..vkstaeeekatyie.rkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGv

GRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
||||| .|.. ..........   . ..|..|| .| . .|| .|| ......|... 
GrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 93-341 1.8e-39 130.3 In-house 26-277 (287) alignment 
Range on Protein: 93-341
Range on HMM: 26-277/287.0
MTQNAFNANQSANinETKNRYADVPCQDQN-IVLVAKPPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKC
.|    .|.. |.    |||||||   |.. ..|.|..   |||. ||.|      |..||..|||.  || ||| .......  .... . .| .. ||
statfkaaeelaa..vkknryadvlPiddtrvllsaegelGsdyinanyvas.ytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

AQYWPLAmgEKKEVKGGIVVENVSGTKpmdRDAEIQITTLQVSFGDQKM--SVRHLHWSDWPDRGVPPC--KLTS--LEL---LSAVR-GSRV-PIVVHC
 .|||    |.    ||  |  .. ..   .. |  . .|..   . .    |. |.. .|||....|    |    |.    . . | .| | |.|||.
ykywPer..evPmrvGGysvvlldydi...kePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGIGRTGTIVAIEYILERIAENKQCPPMpDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
..||||.|...|.  ...|  .  .  .    |  || .||  .|. .|. ..   .  |.
dvGiGrsGillatlvlvsrledlGrvdva.avvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 94-343 4.1e-42 139.3 In-house 40-286 (297) alignment 
Range on Protein: 94-343
Range on HMM: 40-286/297.0
TQNAFNANQsaNINETKNRYADVPCQDQNIVLVAKPP-A-PSDYVHANFVGCPMVpdkRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKyKC
.|..  |..  ..|  |.||...   |.. | .|       |||| | ||        |.|.|| | . ||.||| |.....|  |||| .  |. | ||
iqpqtvaek..kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kc

AQYWPLAmGEKKevKGGIVVENVSGTKpmdRDAEIQiTTLQVSFGD--QKMSVRHLHWSDWPDRGVPP--CKLTSLELLSAVRGS-----RVPIVVHCSA
|.||.   | ..   | ..|.  | ..   |   |.  .|.|. |.  ..  |.  .. .|||. |.      . |.|.| || .       |..|||.|
aryWsdk.gvtt..fGdvsvvllsvse...reGfik.relevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcla

GIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
|.|||| ...|. .. .. ..|.   . .||| ||..| | .||. || ... ..|...| 
GvGrtgvlltidsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavlealls
0049772 (Phosphotyrosine protein) phosphatases II 94-343 2.8e-34 114.7 In-house 33-282 (314) alignment 
Range on Protein: 94-343
Range on HMM: 33-282/314.0
TQNAFNANQSANINETKNRYADVPCQDqNIVLVAK-PPAPSDYVHANFVGCPmvpdKRFICTQGPLDHTVDDF----------WWMIV--QQKVEQIVM-
... .    .   | .|||| |... | | | . . |   ||| .|..| ..    ..||.|||||..||.||          | |..  ...|  ||| 
lpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LCKTIETGKYKCAQYWPLAMgekkevkggivvenvsgtkpmdrdaeiQITTLQVSFgdQKMSVRHLHWsDWPDrGVPPCK
                    |..  . | . .|....|                             .... .  |  ... ...|.. ..|| | .|  
rdevladelsrLdaAlgKtpllildgngneptaadlellk...........................eelydpelf..erlgikylri.pvpD.gsapll

LTSLELLSAVRG--SRVPIVVHCSAGIGRTGTIVAIEYILERIaenkQCpPMPDLVKSLRDQRA-----YSIQTDMQYLYIHRVMLNYFLE
   .|.| ...      |..|||.||.||||| |.. |.. .     .. .. . .. .| .|       .|.. .||..|....|.|.  
edfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_eak_pd Subfamily eak 94-256 1.6e-11 38.2 In-house 38-195 (332) alignment 
Range on Protein: 94-256
Range on HMM: 38-195/332.0
TQNAFN---ANQSANINetKNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCPMVPdKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYK
 |..     ...  ..|  .| .  || . ... | .    .  |. |  .  . |  ...| |  . .  |  || |...||   ||.| . .| .  |
yqrllsisetarleavn..rnvvkivpydrylvrltssqlnrlGyinaslaefsevG.rkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

CAQYWPLAMgeKKEVKGGIVveNVSGtKPMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVP
  .|.|     ..|.| ||.  .|   |   . . ..   |..| |..   | | .   | .  .|
sdkyfpdkt..reelkfGil..dver.kefvkrniletrllelskGnethrvlhykvfGwtettlp
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 96-340 9e-56 184.2 In-house 35-282 (305) alignment 
Range on Protein: 96-340
Range on HMM: 35-282/305.0
NAFNANQSANINETKNRYADVPCQD-QNIVLVAKPPAP-SDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQ
.  .  .. . |..|||....  .| . | | .|.  . |||. |..|       |..| .||||..||.||| .||. ||..||||.|..| || || |
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk.rkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrq

YWPLAMGEKKEVkGGIVVENVSGTKPmdrdAEIQITTLQVSF---GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR-----GSRVPIVVHCSAGIG
||| ...||||  | ..||  | ..     ..  .  |..|.    ... .| ...  |||| |||    . |.|.  |.     .  ||..||||||.|
YWpesktekkef.gefsvelksekta....sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNY
|||. .|..  |||. . ..   . ...| || .| . .||  || ..| .. ..
RtGvfiavdialerlkkEevvd.vfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 96-341 1.1e-50 167.2 In-house 17-268 (274) alignment 
Range on Protein: 96-341
Range on HMM: 17-268/274.0
NAFNANQSANINETKNRYADV-PCQDQNIVLVAKPP-AP-SDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCA
|  .....   ..||||| .. | .   ..| .. . .. |.|. ||..  .   .| .. ||||| .||.||| || |..|. |||| |  |. . |||
nfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCa

QYWPLAMGE-KKEVKGGIVVENVSgtkpMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR-------VPIVVHCSAGI
.|.| | .   .|  |.. .....    . .  . ....| ..   .. || |  ..||||. .|    | |.|.  |. ||        |.||||||||
vyfPdaedyeiserygdveikvek....iverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGi

GRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
||||  .||.  . .. |..    .  .|  || .|   .||. || .|||..  | 
GrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_egg_pd Subfamily egg 96-343 1.1e-39 131.0 In-house 30-272 (307) alignment 
Range on Protein: 96-343
Range on HMM: 30-272/307.0
NAFNANQSANiNETKNRYADVPCQDQNIVLVAKP--PAPSDYVHANFV-GCPMVpdKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETgkYKCA
 ...   |.| | .| |   |.|.|   | .  .      |..||| | | |..    ||..| ||  |||||| |. |..|. ||||  . |.   .| 
islttaasdn.nlekarskrvhckdssrvklelrrGqylddfihanrvkGkpll..nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPLAMGEKKEV-KGGIVVENVSGTKpmDRDAEIQITTLQVsFGDQKMSVRHLHWS-DWPDRGvppCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTI
 ||| |  .   .  |.. .||.   .    |   ..| |..  | ..      ||  |.   .      . |..|  .|    |.||..  |. ...|.
yywpkaesdslvtvpGslrienlkvds..kadplfrvtklkl.vGgddeerflehwqgdvnnss...dvysplrvlrklrnlskpvvvqdilGvskaatl

VAIEYILER-IAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
||||  |   .       ..   |. || .| .|... ..||...|..| .| .
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 99-341 7.5e-34 111.8 In-house 32-293 (301) alignment 
Range on Protein: 99-341
Range on HMM: 32-293/301.0
NANQSANINETKNRYADVPCQDQNIVLVAKPPA----PSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQY
.  .  . |.. ||. ..   |.| ..... |.      .|. |...   .   |.|| .|||...|. ||| .|.|.|. .|||.... |. | || ||
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg.ysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqy

WPLAMGEKKEVKgGIVVENVSGT-KP--MDRDAEIQ----------ITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLS-----AVRGSRVPI
|| .  |..|.   . |. |. .  |  . |.  ..          . ...|.   . ..|  |.  |||. || . . | |. .        . .  |.
wpnseaeseefg.pftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

VVHCSAGIGRTGTIVAIEYILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
|||||....|.|. ....  ||    .     . ...|..| ..   ..|  ||  |. |.  |.
vVHCSdtVsrsGvYcsvsiglEQckae.gVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 99-341 1.2e-31 104.7 In-house 25-259 (267) alignment 
Range on Protein: 99-341
Range on HMM: 25-259/267.0
NANQSANINETKNRYADV-PCQDQNIVLVAKppaPSDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTietGKYKCAQYWPL
 .   |. |. .||. |. | .|. ..|  |     .|. | .| .     . || ||.||. |. ||. .| .|||  ||.| |.   .. .  ..|| 
isqsiaeknqernrlddnlpyddtrvilrtk...eeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPP

AMGEKKEVKGgIVVENVSgTKpmdRDAEIQITTLQVSFGDQKM-SVRHLHWSDWPDRGVPPCKLTSLE-LL--SAVRGSRVPIVVHCSAGIGRTGTIVAI
 ||. |. .  ..||     |    . . || ||.. | ..    |   ..  |         |  |  .|    .     |.||.||.|.||.|| . |
kmgqakkyqd.ltvehsl.ek...eendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvi

EYILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
.  |||. .. .   . |... .|.||   ..|  .|.|||... .| 
dsqlerakte.gvsdifdflrkirsqriglvdtkeryiyihellaeya
0050432 (Phosphotyrosine protein) phosphatases II 100-345 3.6e-80 264.9 In-house 61-303 (308) alignment 
Range on Protein: 100-345
Range on HMM: 61-303/308.0
ANQSANINETKNRYADVPCQDQNIVLVakpPAPSDYVHANFVGCPM-VPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLA
   .   | .|||| |... |.. | .   . .|||..|..| ...   ...||.|||||..||.|||.|. .|.|. ||||.|..| |. |||||||| 
svallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwple

MGEKKEVKGGIVVENVSGTKpmdrDAEIQITTLQVSF--GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS--RVPIVVHCSAGIGRTGTIVAIE
.|.. .. |...|...| ..    .... ..||....  ...   |.|.|. .||| ||||     |..| .|| |    |||||||||.|||||..|..
lgggsleygkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfiald

YILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
..||.. .. ... ....|| || ||....|| .|||...|..| |.. |.
llleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPN1_pd Subfamily PTPN1 100-332 2.5e-42 139.6 In-house 25-262 (290) alignment 
Range on Protein: 100-332
Range on HMM: 25-262/290.0
ANQSANINETKNRYADVPCQDQNIVLVAKPPApsDYVHANFVGCPMVpDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAM
..   . | ..||| ||   |   . . .     ||. |..|  . . ....| ||||| .||| || |. .||   .||| | .| .. |||||||   
reaklpenrnlnryrdvspydhsrikleradn..dyinaslveleea.krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

GeKKEVKGG---IVVENVSgtkpMDRDAEIQITTLQV--SFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR------VPIVVHCSAGIGRTG
  .||..     . |. .|     .|  . .. .|..     ..  .. | |.  ||| ||| .  . |..|  || |        | |.||||||||.|
e.ekellledtklkvklis....eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

TIVAIEYILERIAENKQ--CPPMPDLVKSLRDQRAYSIQTDMQYLY
|.. .. .| .| ....  .  . . .  || .|   |||  |  .
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf
subfamily_CG42327_pd Subfamily CG42327 101-271 2.9e-19 63.9 In-house 22-192 (319) alignment 
Range on Protein: 101-271
Range on HMM: 22-192/319.0
NQSANINETKNRYAD-VPCQDQNIVLVAKPPAPSD-YVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLA
..     . |.|... ||  . ..||  ..  ..| |..|..|  .   .  .|..| .|. .  ||| .. .|.   || |..  | |  .||.|.|  
devPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

MG-EKKEVKGGIVVeNVSGTKPMDRDAeiqITTLQVSFGDQKMS--VRHlHWSDWPDRGVPPCKLTSLELLSAVRG
 . . ... | | |  . | .  || |   |.|| .   |...|  . | .| .|.. .||  . . . .|  || 
etldntslyGdilv.tlkgrevkdrya...istlllkrvdkeesrelth.ywykwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 102-348 2.6e-26 86.8 In-house 46-292 (302) alignment 
Range on Protein: 102-348
Range on HMM: 46-292/302.0
QSANINETKNRYADVPCQDQNIVLVAKppAPSDYVHANFVGCPMVPdKRFICTQGPLDHTV---DDFWWMIVQQKVEQIVMLCKTIETGKyKCAQYWPLA
..   |  ||.  |||. |.|.| ...  .| .||.|  |  | .  .  | .| |   ..   ..|| |. |.|. ..|.| .. |  |    ...|. 
kafkknlkknqsedvpildsnlvklea..epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

MGEKKEVkGGIVVENVSGTKPMDRDAEIQITTLQVSFGDQKMSVRHlHWSDWPDRGVPPCKLTSLELLSAV----RGSRVPIVVHCSAGIGRTGTIVAIE
.|. ||  | . | |    |  .   .  |  |   . .  ..    . . |..  ||    .  .    |      .  ..|.    |.|| |....  
sgdykey.gkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy.vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltla

YILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDK
  .|.. .. . | . ..|||.| ||. ....  ||  .....| |...| .. 
vaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkp
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 103-340 2.2e-47 156.2 In-house 46-279 (301) alignment 
Range on Protein: 103-340
Range on HMM: 46-279/301.0
SANINETKNRYADVPCQDQNIVLVAKPPApSDYVHANFVGCPMVPdKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEK
 | ... |.||  |||. .  | | .       .|||..  .  | .|||.|||||. | .||| |.|| .||.||||....|  . ||..| |. ..||
yaylpkdkhryptvPckPstavevivdGk.rvPihanwiptsGhp.hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

KEVKGgIVVENVSgTKPMDRDaEIQITTLQVSFGDQKMS---VRHLHWSDWPDRGVPPCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILER
 ...    .. .. .. . .. .|.  ||.|    .|..   | |  .|.|.|||||  .    .|.  |. |. ||||||||||||. . .. ||.  .
ldigr.fkikikn.kelilnk.kiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylare

IAENKQCpPMPDLVKSLRDQRAYSIQTDMQyLYIHRVMLNY
.  ...   . . .| ||..|  ..||  | ||  ..   |
veadpti.eltealkhlrehrwngvqtnsq.lywmtlGtvy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 103-256 1.9e-37 123.8 In-house 27-180 (297) alignment 
Range on Protein: 103-256
Range on HMM: 27-180/297.0
SANINET--KNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCPMVP-DKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAM
||. | .  |||| |.   |.. | . . .. .||. |..|  |  . | ..|..||||. |||||| ....| |  |||..|  | |. ||| ||| . 
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

GEKKEvKGGIVVENVSGTKpmDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVP
.|...  | .||| .| |   |    ...| ||. . ...  |||  .  ||| |||
qerlk.agdvvveflssts..defdrviltelqliyrsesrvvrhvqflswpdhGvp
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 104-342 3.6e-48 158.9 In-house 40-277 (515) alignment 
Range on Protein: 104-342
Range on HMM: 40-277/515.0
ANINETKNRYAD-VPCQDQNIVL-VAKPPAPSDYVHANFVGCpMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGE
 .|| .|||| . .| . . . | | .    |||. | ..   .  || .|..|||.. .||||| ...|..|  |.|. |  |  | ||..|||   |.
eeinfkknryknilPydsvrvklevindnPhsdyfnasyips.fdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

KKEVkGGIVVENVSgtkpMDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR----VPIVVHCSAGIGRTGTIVAIEYIL
  .  | | || ||    .. ...  . .|.|  ||.   |   |. .|||.|||.   . | |. .|. ..     |...|||||.|||| ...|. ..
svkf.Gsikvelvs....leactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvv

ERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
 .... .    . ..|. .|..| | .||. || .|. ..|...|
ahakttrmv.dvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPRK_pd Subfamily PTPRK 105-339 6.8e-45 148.2 In-house 41-275 (314) alignment 
Range on Protein: 105-339
Range on HMM: 41-275/314.0
NINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMVPdKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamgEK
. |..|||. |.   |.  | .      . |||. |...     | . || |||||..|| ||| .. ...   |||| . .|.|..|| .|||    |.
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrp.aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP....ed

KEVKGGIVVENVSGTkpMDRDAEIQITTLQV--SFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS----RVPIVVHCSAGIGRTGTIVAIEYI
 || | | || |. .  .. .  ..| ...      ...  ||....  ||| .||  . . |.|.  |  |      .|||||||| ||||| .||. .
tevygdikvelvete..llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

LErIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLN
|. ..|...   .   ||.||...   ..|  || .|. |.|.
ld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 105-338 7.2e-34 112.0 In-house 5-237 (239) alignment 
Range on Protein: 105-338
Range on HMM: 5-237/239.0
NINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEK
 .|..|||||..   |.. |.. |      |||. |...       | .|.||| .  .  ||| |. |..   ||||   ||  | || |||| .  . 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

KEVKGGIVVENVSgtkpmdrdAEIQITTL---QVSFGDqKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR-----GSRvPIVVHCSAGIGRTGTIVAIE
 ...  .   .|         |.  | |.   ||   . .  | . |.. |||.|||    . | |   .      |.| | |.|||||.||||... |.
cnlrvtlrktevf........adyiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar.pwvihcsagvgrtgaflvid

YILERiAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVML
 .| . |....   . . ||..|..| . .||  ||..||  .|
amlrq.akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 105-338 7.6e-34 111.9 In-house 6-238 (239) alignment 
Range on Protein: 105-338
Range on HMM: 6-238/239.0
NINETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEK
 .|..|||||..   |.. |.. |      |||. |...       | .|.||| .  .  ||| |. |..   ||||   ||  | || |||| .  . 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

KEVKGGIVVENVSgtkpmdrdAEIQITTL---QVSFGDqKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR-----GSRvPIVVHCSAGIGRTGTIVAIE
 ...  .   .|         |.  | |.   ||   . .  | . |.. |||.|||    . | |   .      |.| | |.|||||.||||... |.
cnlrvtlrktevf........adyiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar.pwvihcsagvgrtgaflvid

YILERiAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVML
 .| . |....   . . ||..|..| . .||  ||..||  .|
amlrq.akkqktvdifnyvkairedrphmvqtseqyvfihlavl
0040439 (Phosphotyrosine protein) phosphatases II 106-343 2.3e-68 225.8 In-house 10-248 (249) alignment 
Range on Protein: 106-343
Range on HMM: 10-248/249.0
INETKNRYADVPCQDQNIVLVAKPPA--PSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLamgEKK
 |  |||| |... |.. | .   |   .|||..|... .. .... ||.|||||..||.|||.|. ..... ||||... | |. ||||||||   .. 
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggs

EVKGGIVVENVSGTKpmdrDAEIQITTLQVS--FGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG------SRVPIVVHCSAGIGRTGTIVAIEY
 . |...|...| ..     ... ..||...    ...  |.|... |||| ||||   . |... |||       .  |..||||||.|||||..|. .
leygdftvtllsvev....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ILERIAENkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLE
.||.. .. .. .... || ||.|| ...|.. || ......| ..|.
mleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 106-341 9.3e-67 220.3 In-house 8-243 (245) alignment 
Range on Protein: 106-341
Range on HMM: 8-243/245.0
INETKNRYADVPCQDQNIVLVAKPPAP--SDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLamgEKK
 | .|||| |... |.. | .  ..    |||..|..|... ...| ||.|||||..||.|||.|. ..... ||||... | |. ||||||||   . .
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...ges

EVKGGIVVENVSGTKpmdrDAEIQITTLQVS--FGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG-----SRVPIVVHCSAGIGRTGTIVAIEYI
 . |...|...| ..    .... ..||.|.    |..  |.|.|. .||| |||.   . |..|..||      |  |..||||||.|||||..|. ..
ltygdftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LERIaENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
||.. |  .. .... || ||.||  ..||. || ......|...
leql.ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 106-341 4.6e-63 208.3 In-house 9-242 (243) alignment 
Range on Protein: 106-341
Range on HMM: 9-242/243.0
INETKNRYADVPCQDQNIVLVakPPapSDYVHANFVGCPmvpdKRFICTQGPLDHTVDD----FWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamGE
 | .|||| |... |.. | .  ..  |||..||.. ..    .|.|.|||||..||.|    || |. ..... ||||....| |..|||||||   ||
enlsknrysdilpydhsrvkl..eg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

KkeVKGGIVVENVSGTKpmdrDAEIQITTLQVSF---GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR------------GSRVPIVVHCSAGIGR
.  . |...|...| .      ... ..||...    .|..  |.|.|.  ||| |||.     |..|..||             |  |..||||||.||
v..tygdftvtllseeh....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTIVAIEYILERIaenkqCPPMPDLVKSLRDQRAY-SIQTDMQYLYIHRVMLNYF
|||..|. ..|...     . .. . || ||.|| . ..||  || ......| ..
tGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 106-341 5.8e-53 174.6 In-house 8-242 (250) alignment 
Range on Protein: 106-341
Range on HMM: 8-242/250.0
INETKNRYADVPCQDQNIVLVAKPP--APSDYVHANFVGCPMVPdKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYkCAQYWPLamgEKK
 |. ||||||.   |.  |.. |      |||. | |.   .   | || ||||| .|. ||| |....|.. |||| .  |..|  . ||||    || 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv...eka

EVKGGIVVENVSgtkpMDRDAEIQITTLQVSFGDQKMS--VRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR-----VPIVVHCSAGIGRTGTIVAIEYI
|  |.. |.  |     .  |......|..|   .. .  ||.||.  |||.|||    . ||||. |. |.      |..|.||||.||.|. .||. .
ekyGdvtvslls....keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
|||. ..|.   . ...| || .|  ....  || ......|.. 
lerlkkekvv.dvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 106-355 3e-44 146.2 In-house 48-301 (315) alignment 
Range on Protein: 106-355
Range on HMM: 48-301/315.0
INETKNRYADVPCQDQNIVLV--AKPPAPSDYVHANFVGCPMVPDkRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlamgEKK
 |  |||| ..   |.  | .   .    |||| |||.     .. |.|..|||.  .|.||| .. .... .|||| ...|  | |. .|||    .||
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr.ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp....dkk

EVKGGIVVENVSGtkpmDRDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVR----GSRVPIVVHCSAGIGRTGTIVAIEYILER
 . | | |  .|     .   |. . || | |||.   |  ||.. ||| |||   .. ..|   |.     |  .||||||||.||||| .... .|..
viyGkitvtrkse....evnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldq

IAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL--------EKYKDKYAALLNP
.  ..    . .... .|..|   .|.  || .|. ..|. |.        . | ..| .|| |
aeaenai.dvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllap
0036941 (Phosphotyrosine protein) phosphatases II 107-345 1.9e-76 252.5 In-house 39-281 (297) alignment 
Range on Protein: 107-345
Range on HMM: 39-281/297.0
NETKNRYADVPCQDQNIVLVakPPAPSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVk
| .|||| |... |.. | .  .. .|||..|..| .. .. | ||.|||||..||.|||.|. .|.|. ||||.. .| |. |||||||| .|| ... 
nleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslty.

GGIVVENVSGTKPmdRDAEIQITTLQVSF--GDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG------SRVPIVVHCSAGIGRTGTIVAIEYILE
|...|...| ..    .... ..||.|..  ....  |.|.|. .||| |||..  . |... .||       |  |..||||||.||.||..|....|.
gdftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlq

RIAE--NKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
.. .    ........||.||.||. ..|| .||.......|.... |.
qledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
Y_phosphatase Protein-tyrosine phosphatase 107-339 1.3e-73 242.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 107-339
Range on HMM: 1-235/235.0
NETKNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEkKEVK
|..|||| |... |.. | . . . ||||..||.|      .|.||.|||||..|..|||.|..|.||. ||||..  | |. ||||||| ...| ..  
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.slty

GGIVVENVsgTKPMDRDAEIQITTLQVSFGDQKM---SVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR----VPIVVHCSAGIGRTGTIVAIEYILER
| | ||..  .|  . ..|.....|...  ...    .|..||. .|||.||| ..   |.|. .|. |.     |.|||||||.|||||.||....||.
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IAENKQcPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLN
. .... . . ..||.|| ||. ..|.  || ......|.
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 107-339 1.3e-73 242.6 In-house 1-235 (235) alignment 
Range on Protein: 107-339
Range on HMM: 1-235/235.0
NETKNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEkKEVK
|..|||| |... |.. | . . . ||||..||.|      .|.||.|||||..|..|||.|..|.||. ||||..  | |. ||||||| ...| ..  
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.slty

GGIVVENVsgTKPMDRDAEIQITTLQVSFGDQKM---SVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSR----VPIVVHCSAGIGRTGTIVAIEYILER
| | ||..  .|  . ..|.....|...  ...    .|..||. .|||.||| ..   |.|. .|. |.     |.|||||||.|||||.||....||.
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IAENKQcPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLN
. .... . . ..||.|| ||. ..|.  || ......|.
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0045098 (Phosphotyrosine protein) phosphatases II 107-343 1.5e-67 223.2 In-house 33-274 (278) alignment 
Range on Protein: 107-343
Range on HMM: 33-274/278.0
NETKNRYADVPCQDQNIVLvakppapsDYVHANFVGCPmvpDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPlAmgEKKEVK
|  |||| |... |.. |         ||..|... ..   .|.||.|||||..||.||| |. ..... ||||.. .| |..|||||||    .. .. 
nldknRykdilpydhsrVk........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e..ggslty

GGIVVENVSGTKPmdRDAEIQITTLQVS----FGDQKMSVRHLHWSDWPDRGVPPCK--LTSLELLSAVRG-----------------SRVPIVVHCSAG
|...|...| .     |  .   ...       ..... |.|||.  ||| |||.       ||||  .|                  |  |..||||||
gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

IGRTGTIVAIEYILERIaenKQCPPMPDLVKSLRDQRAY-SIQTDMQYLYIHRVMLNYFLE
.|||||.||. ..||..   ..   ... || || || . ..|. .|| ......| ..| 
vgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 107-341 6.7e-49 161.3 In-house 20-264 (270) alignment 
Range on Protein: 107-341
Range on HMM: 20-264/270.0
NETKNRYADVPCQDQNIVLVAKP--PAPSDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKE
... |||||.  . .  | ...      . |. ||.|      .|..|...|||. |. .|| ||...||. |||. .  | |. ||..|||   .|| .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

VKGGIV-VENVSGTKpmdrDAEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKL------TSLELLSAVRGSR------VPIVVHCSAGIGRTGTIV
.. | . | ..| .|    .    .| |..    ..  . | .. .|||.|||. .         |..| ||| |.       |..||||||.|||||..
ledgkikvlalseek....eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

AIEYILERIAENKQCPPMpDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
|...... . |.|.. ..  ... || .|   .|.  || ........| 
alDiavrlLeetkkvdvl.aiieelRkdRmalvqhpeqyeflykavveya
0041856 (Phosphotyrosine protein) phosphatases II 107-345 1.6e-45 150.3 In-house 1-175 (182) alignment 
Range on Protein: 107-345
Range on HMM: 1-175/182.0
NETKNRYADVPCQDQNIvlvakppaPSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCktietgkykCAQYWPlamgekkevk
| .|||| |... |...        ..||..||.. ... ... ||.|||||..|| ||. |. ....  ||.|.         . .|||          
nldknrysdilpydhsr........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

ggivvenvsgtkpmdrdaeiqittlqvsfGDQKMSVRHLHWSDWPDRGVPPcKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERiaenkqC
                              . .  . ....  ||| |||.   . |... .|. .  |..||||||.|||||.||. .....       
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......g

PPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
 .... || .| .|  ...|  || ......| ..| |.
vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 107-338 5.9e-39 128.7 In-house 3-236 (237) alignment 
Range on Protein: 107-338
Range on HMM: 3-236/237.0
NETKNRYADVPCQDQNIVLVAKPPAPSDYVHANFVGCPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAmgEKKEVK
|. ||||... . |.. |..  . . |||. |...       |..|..||||. . |||| |. |.|   ||||   ||  . || .||| .  .. .  
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst..dqpaay

GGIVvenVSGTKpMDRDAEIQITTLQVSFGDQKMSVRHL---HWSDWPDRGVPPCKLTSLELLSAV-RG-----SRVPIVVHCSAGIGRTGTIVAIEYIL
| .    || .|  .  ..  . .| .|   ..  || .   ... |||||||    . | .   .           | ..|||||.|||| .. |. .|
gvlt...vslkk.keefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

eRIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVML
 | |..|.   . . |.|. ..| | |||  ||..||...|
.rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 108-232 6.3e-19 62.9 In-house 48-188 (350) alignment 
Range on Protein: 108-232
Range on HMM: 48-188/350.0
ETKNRYADVPCQDQNIVLVA---KP-------PAPSDYVHANFVGCP-----MVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCA
 .|||| ..   ... | .    |.         ..||. ||..  .     . || ..| ||.||  |||||. .|.. ||. |..| . .| .  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPLAMGEKKEVKGGIVVENVSGTKPMD-RDAEIQITTLQ
.||.    ... ||     ||. |.. .  . |...... .
rYWqegsydditvklaskwenimgindsslysadvkkeasd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 110-348 3.9e-41 135.8 In-house 46-283 (312) alignment 
Range on Protein: 110-348
Range on HMM: 46-283/312.0
KNRYADVPCQDQNIVLVAKppAPSDYVHANFVGCPMVPDkRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMG----EKKEV
 ||| .. | |.    .|       |.|||||     |. ||.||||||. |.  || . .      |..||  .| |  |||.|    .|    | . |
lnrypniqcwdrgrftlag..denfyihanfvkictkpe.rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

KGGIVVENVSGTKPMDRDAEiQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQ
    . |   | |  |. .  ..  . |    |.  . |  |. ||| |.|    |.| |||||.  . |.. |||||.|||||.. || ..  .   ..
yteycteieiggkskdkith.rvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprk

CpPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDK
   . |    || .|| |...  ||.|  |..|...  |   |
q.nvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
0046846 (Phosphotyrosine protein) phosphatases II 126-341 5.2e-42 138.9 In-house 5-173 (176) alignment 
Range on Protein: 126-341
Range on HMM: 5-173/176.0
VAKPPAPSDYVHANFVGCPmvpdkRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKevkggivvenvsgtkpmdrdae
.  .. ..||..||.. ..     |.|.||||| .|. ||. |. ..... .|.|.. .|.|..||..|||. ....                       
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

iqittlqvsfgdqkmsvrHLHWSDWPDRGVPPCkLTSLELLSAVRGSR---VPIVVHCSAGIGRTGTIVAIEYILEriaenKQCPPMPDLVKSLRDQRA-
                  . .. .||| |||.     |||| ..|  .    |..||||||||||||.||.  .       ... .. . .. .|.||  
..................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRpl

YSIQTDMQYLYIHRVMLNYF
...||. || ......| ..
gavqtpeQyrflyefellll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 131-206 5.8e-14 46.2 In-house 88-164 (349) alignment 
Range on Protein: 131-206
Range on HMM: 88-164/349.0
APSDYVHANFVGCPM-VPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVK
 . ||. ||..  .   ..|..|.|| ||  |||||. .|. ..|. .. | .  |..  || .||     . ..||
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 132-348 1.2e-40 134.4 In-house 45-266 (290) alignment 
Range on Protein: 132-348
Range on HMM: 45-266/290.0
PSDYVHANFVGCPMvpDKRFICTQGPLDHT-------VDDFWWMIVQQKVEQIVMLCKTIETGKY----KCAQYWPLAMGEKKEVKGGiVVENvsgtKPM
 .||.|||.| ||   . |.| || |. ..       . .||||. | ||.|.||||.  |  .      ||.| | ..||.  .||   |.     | .
nddyiHAnrvtcpn..glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl.tvkC....ksk

DRDAEIQITTLQVSFGDQK-MSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQ
  . .... .| | |.|.. . | |   ..| .. |.. ..| |.|.. |. |. |..|||  || |  .. ||.     ||| ..   . |..|.|| |
ekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

RAYSIQTDMQYLYIHRVMLNYFLEKYKDK
||  |...... ..  ... .. | ..  
ralaitsalelafvdagivllaievldqf
0043147 (Phosphotyrosine protein) phosphatases II 132-334 1.8e-38 127.3 In-house 4-154 (172) alignment 
Range on Protein: 132-334
Range on HMM: 4-154/172.0
PSDYVHANFVGCPMVPDKrFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTietgkykcaqywplamgekkevkggivvenvsgtkpmdrdaeiqittl
.|||..|... .. .||. ||.|||||..|..||| |. ....  ||.|..                                                 
gsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel................................................

QVSFGDQKMSVRHLHWSDWPDRGVPpCKLTSLELLSAVRG-----SRVPIVVHCSAGIGRTGTIVAIEYILeriaenkQCPPMPDLVKSLRDQRAYSIQT
..   . . .. ....  ||| |||      ||.|. ..      .  |..||||||.|||||.||. ..|       .. .. . |. .|..| ...|.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqn

DMQYLYIH
. || ...
psqyrfly
0044763 (Phosphotyrosine protein) phosphatases II 132-341 2e-28 94.6 In-house 17-171 (178) alignment 
Range on Protein: 132-341
Range on HMM: 17-171/178.0
PSDYVHANFVGcpmvpDKRFICTQGPldhtvDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGekkevkggivvenvsgtkpmdrdaeiqittl
 ||| .|...      .  ......|      |.. .. ....  ||.|....| |..|| .|||  .|                               
rsdyinaseil.....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

qvsfgdqkmsVRHLHWsDWPDRGVPPCKLTSLELLSAVR----GSRVPIVVHCSAGIGRTGTIVAIEYILERiaenkQCpPMPDLVKSLRDQRAySIQTD
          ...||.  .|| |||.     ||.. ...     .  |..||||||.||.||.||. .....     .. .... .. .| .|   ....
..........iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaielvrerRp.ivpnp

MQYLYIHRVMLNYF
 |. ..... | ..
gqlrqLyefelrll
0051429 (Phosphotyrosine protein) phosphatases II 133-345 1.9e-45 150.9 In-house 4-229 (272) alignment 
Range on Protein: 133-345
Range on HMM: 4-229/272.0
SDYVHANFVGCP--MVPDKRFICTQGPLDHTVDDFWWMiVQQKVEQIVMLCKTIETGKYKCAQYWP---------LAMGEKKEVKGGIVVENVSGTKPMD
|.|..|..|| .  .| ..|.....|||..|..|||..  ....  ||.|... | |..|| .|||         | ...     | ..| ..| .   |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

rdaeIQITTLQVS---FGDQKMSVRHLHWSDWPDRGVPPCKltSLELLSAVRGsRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPP-------MPD
    . ...|...     .. . |.|||. ||||.|||.     ||||....    |..||||||..||||.||. ..|... ..  .         . .
....yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

LVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKY
 |. ||.||....||..|||......|... . .
aveelraqrpgavqteeqylflyeallellrsll
0036282 (Phosphotyrosine protein) phosphatases II 133-335 2.7e-40 133.2 In-house 2-164 (174) alignment 
Range on Protein: 133-335
Range on HMM: 2-164/174.0
SDYVHANFVGCPMVPDkRFICTQGPLDhtvddFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLamgekkevkggivvenvsgtkpmdrdaeiqittlq
||| .|....  .... |.|..||||.     || |. ..... .|||.. .| |.||| .|||                                    
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

vSFGDQKMSVRHLHWSDWPDRGVPPCKLtSLELLSAVRGS-----RVPIVVHCSAGIGRTGTIVAIEYILERIAenKQCPPMPDLVKSLRDQRAYSIQTD
    | . .. ....  |||.|||.     ||....|.         |..||||||.|||||.||. ..| ..          |||..|| || ...||.
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp

MQYLYIHR
 || ... 
sQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 133-337 1.3e-30 101.3 In-house 3-149 (151) alignment 
Range on Protein: 133-337
Range on HMM: 3-149/151.0
SDYVHANFVGcpmvpdKRFICTQGPLDhtvdDFWWMIVQQKVEQIVMLCKTIETGkyKCAQYWPLAMgekkevkggivvenvsgtkpmdrdaeiqittlq
||| ....|.       ......|||.    ||. .. ....  ||.|... |.|  .|..|.| .                                  
sdyinfsyvt......gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

vsfgdqkMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS-RVPIVVHCSAGIGRTGTIVAIEYILERiaenkqcPPMPDLVKSLRDQRAYSIQTDMQYL
       . |.|... |||| |.| .  . ||.|....     |..||||||.|||||.||.  .|..        .. . .. .| .| ...|. .|.|
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

YIHRVM
......
fqlfal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 134-191 2.1e-07 25.3 In-house 14-70 (130) alignment 
Range on Protein: 134-191
Range on HMM: 14-70/130.0
DYVHANFVGCPMvPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKC
.|..|.|||.     . .. || ||  |  ||| |.... |. .|.|    |  .|  
tyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 148-335 3.6e-12 40.9 In-house 4-198 (199) alignment 
Range on Protein: 148-335
Range on HMM: 4-198/199.0
DKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVSGTKPmDRDAEIQITTLQVSFGDQKMSVRHLHW
..|.|.|| || .|. ||| |. .    .|||.       .   . ||| .     .     |. ..  ||| |      | | ...       . |  .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dytitaliltnnttappstreishyqf

SDWPDRGVPPCKLTSLELLSAV-------RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQC-PPMPDLVKSLRDQRAYSIQTDMQYLYIHR
. | ..  |   |    ....        .    |..|||| | | || .||..  .    | |     . .. | ||. |   | .  .| .|..
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0049260 (Phosphotyrosine protein) phosphatases II 149-334 3.6e-36 119.5 In-house 9-143 (152) alignment 
Range on Protein: 149-334
Range on HMM: 9-143/152.0
KRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWplamgekkevkggivvenvsgtkpmdrdaeiqittlqvsfgdqkmsvrHLHWS
..||.||||...|..||| |. ....  ||||..  | ||.||.||.                                                . .. 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylhl

DWPDRGVPPCKLTSLELLSAV----RGSRVPIVVHCSAGIGRTGTIVAIEYILeriaenkQCPPMPDLVKSLRDQRAYSIQTDMQYLYIH
 ||| |||.     |.|| ..    . .  |..||||||.|||||.||. ..|       .  .. . |. .| .| .....  |. ...
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 149-335 3.7e-12 40.8 In-house 4-197 (198) alignment 
Range on Protein: 149-335
Range on HMM: 4-197/198.0
KRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVSGTKPmDRDAEIQITTLQVSFGDQKMSVRHLHWS
.|.|.|| || .|. ||| |. .    .|||.       .   . ||| .     .     |. ..  ||| |      | | ...       . |  ..
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dytitaliltnnttappstreishyqft

DWPDRGVPPCKLTSLELLSAV-------RGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQC-PPMPDLVKSLRDQRAYSIQTDMQYLYIHR
 | ..  |   |    ....        .    |..|||| | | || .||..  .    | |     . .. | ||. |   | .  .| .|..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 150-235 4e-08 27.0 In-house 237-313 (440) alignment 
Range on Protein: 150-235
Range on HMM: 237-313/440.0
RFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIEtgkYKCAQYWPLAMgekKEVKGGIVVENVSGTKPMDRdaeIQITTLQVSF
 ||.|| ||| || ||| .. . ..  |.|| .  .     |. |||.     . |  |       |.. |.|   ... ||.. .
afiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt...rsvtfgpftvghkgsenmnr...vkvrtlelky
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 157-346 2.9e-27 89.9 In-house 99-293 (302) alignment 
Range on Protein: 157-346
Range on HMM: 99-293/302.0
PLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKgGIVVENVSGTKPMDRD--------AEIQITTLQVSFgDQKMSVRHLHWS
|   |.. .| .| | .|  .| ||. .| .. |||.|.   .|.. . .    |. ||  . ...           ..|.  ..   ..|..|  |..|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfg.rytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafs

DWPDRGVPPCKLTSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAeNKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYK
 ||| | |    |.|..|      .  ..||||||.|||||.||| | ..  . .|.   . ..|. .|. |  ..|.. | .|.  ..   ..||  
awpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcs.kkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekag
subfamily_hpo-7_pd Subfamily hpo-7 158-347 2e-25 84.2 In-house 43-233 (263) alignment 
Range on Protein: 158-347
Range on HMM: 43-233/263.0
LDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGivveNVSGTKPMDrDAEIQITTLQVSFGD--QKMSVRHLHWSDWPDRGV
|  |.| |. .|||.| |..||||   | |. || .|.||   ||. ..      ||. || .. |  ..   |   .|.  .   |.|  .  |...  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanv....nvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWieknd

PPCKLTSLELLSAVRGSRvPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPP-----MPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKD
|     .|..| ..|.|. ..|||||.||||.   . .| .  ..  . .  .        |.. || .|. .|.| ||  .   ..|...|. .  
pelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfak
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 159-350 3.4e-07 23.2 In-house 128-318 (346) alignment 
Range on Protein: 159-350
Range on HMM: 128-318/346.0
DHTVDDFWWMIVQQKVEQIVMLcKTIETGKYKCAQYWPLAMGEKkEVKGGIVVENVSGTKPMDrDAEIQITTLQVSFGDQKMSVRHlHWSDWPDRGVPPC
.  |.|||.|| |.... . ..    .  |   .  .    |   .  | ....|       |   |  |  |     |  .   | | . |     || 
esfvedfwymiyqeqihlvylm.vpddklkntttslfndenggy.qytgkmfinnrradvsgd.pkeytievlpegnsdsvicqvh.hhapwkhlqqppk

KLTSLELL----SAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIaENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEKYKDKYA
 |  . ..    |  .   . . |    | ||. ...   | .... .|   | . ...|....||  ....  ||  |. ....|   |   | |
tlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainql.nngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkka
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 161-351 2.9e-28 93.6 In-house 40-233 (255) alignment 
Range on Protein: 161-351
Range on HMM: 40-233/255.0
TVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGgivvENVSGTKPMdRDAEIQITTLQVSFGDQK--MSVRHLHWSDWPDRGVPPC
||| |. .|||.| |..||||   | |. || .|.||   ||. ..      ||. ||..  |  ..  ..   .|..|    |.| ..  |...  |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttkss.advvlrtleitstlgekkkthtvkhysykGWieknaPel

KLTSLELLSAVRGSrVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPP-----MPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF--LEKYKDKYAA
    |..| .|| |  ..|||||.||||. . | .|..  ..  . .  .        |.. || .|. .|.| .|  .   ..|...   .....||  
areilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleakyqe
0048076 (Phosphotyrosine protein) phosphatases II 220-338 1.8e-20 68.5 In-house 22-140 (145) alignment 
Range on Protein: 220-338
Range on HMM: 22-140/145.0
MDRDAEIQITT---LQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG---SRVPIVVHCSAGIGRTGTIVAIEYILEriaenkQCPPMPDLV
... .. .|||   |   . . .  . .... .|||.|||.   . ||.| ...    .  |..||||||.|||||.||.  .|.      .  .... .
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleeal

KSLRDQRAYSIQTDMQYLYIHRVML
. .| || ...... |. ..... |
elvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 232-335 2.8e-19 64.7 In-house 48-139 (144) alignment 
Range on Protein: 232-335
Range on HMM: 48-139/144.0
QvsfgdqkmsVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS---RVPIVVHCSAGIGRTGTIVAIEYILeriaenKQCPPMPDLVKSLRDQRAYSIQTDM
.         . .... .|||.|||.     ||.| ...       |..||||||.|||||.||.  ..      |.  .. . .. .| .| ...... 
e.........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnpg

QYLYIHR
|. ....
qlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 240-342 8e-15 49.1 In-house 89-195 (440) alignment 
Range on Protein: 240-342
Range on HMM: 89-195/440.0
MSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGS-----RVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCpPMPDLVKSLRDQRAYSIQTDMQYLYIH
 .... |.  |||.|||      |...  |  |       |..|||||| |||| |.|.. ||     . |   .  ...|.|..|   .||  || ..|
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqtpeqyafvh

RVMLNYFL
 ..|. .|
eavlegll
PTPc_DSPc_SM00012 242-338 1.9e-30 100.5 In-house 2-104 (105) alignment 
Range on Protein: 242-338
Range on HMM: 2-104/105.0
VRHLHWSDWPDRGVPPCKLTSLELLSAVRGSRV------PIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHR
|.|.|...||| |||      |||| ||. ..       |.|||||||.|||||.||....|... ...... . ..||.||.||. ..||..|||...|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VML
..|
all
0038934 (Phosphotyrosine protein) phosphatases II 245-296 3.6e-08 28.8 In-house 82-138 (194) alignment 
Range on Protein: 245-296
Range on HMM: 82-138/194.0
LHWSDWPDRGVPPCKLTSLELLSAV-----RGSRVPIVVHCSAGIGRTGTIVAIEYI
 .   .||.|..|   . |. |..|     . .   ..||| ||.|||||.||   |
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLi
PTEN_1 249-292 1.4e-07 26.5 In-house 101-149 (196) alignment 
Range on Protein: 249-292
Range on HMM: 101-149/196.0
DWPDRGVPPCKLTSLELLSAVRG-----SRVPIVVHCSAGIGRTGTIVA
...| |.|.      .. |.        ..  ..||| ||.||.||.||
pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 257-342 8.9e-10 32.6 In-house 256-339 (347) alignment 
Range on Protein: 257-342
Range on HMM: 256-339/347.0
PCKLTSLELLSAVrGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKqCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
| | .|  |.. . . . |.|| |  |. |. |.|    |.|.. . |  |   || | .|||||  .   . | |  |  | |. 
pvkesstslianl.eklapvvvmcdlgldrsatvvltsiiieqvldgk.tpdcddlfkkmrdqragvftmsifytyairaalfylk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 262-339 3.2e-14 47.5 In-house 217-293 (297) alignment 
Range on Protein: 262-339
Range on HMM: 217-293/297.0
SLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILErIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLN
 || | |     ....||||||.||.| .|  . ||. .  .|. | .  ... ||.|||  .||  |. ... ..|.
qleslraemprnayllvhcsaGvGrsGvvvlsdvila.klrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPDC1_pd Subfamily PTPDC1 263-335 8.2e-08 26.9 In-house 105-170 (182) alignment 
Range on Protein: 263-335
Range on HMM: 105-170/182.0
LELLSAVRGSRvPIVVHCSAGIGRTGTIVAIEYILERIAENKQCppmpdlVKSLRDQRAYSIQTDMQYLYIHR
  ... .      . ||| || |||| ..|   .  .  . ..       .| .|..|. ||||  |   .. 
vkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvke
PTPc_motif_SM00404 263-330 1.6e-06 23.1 In-house 70-130 (140) alignment 
Range on Protein: 263-330
Range on HMM: 70-130/140.0
LELLSAVRGSRVPIVVHCSAGIGRTGTIVAIeYILERiaenKQCpPMPDLVKSLRDQRaYSIQTDMQY
|. ..... ..  ..||| ||. |..|...  |....    .|.  . . .. ....|  .|.  ...
ldfienaekkggkvlVHCqaGvSRSatliia.Ylmry....rql.slaeayefvkerR.piispnlnf
DSPc Dual specificity phosphatase, catalytic domain 264-299 1.7e-06 23.0 Pfam-A 64-98 (133) alignment 
Range on Protein: 264-299
Range on HMM: 64-98/133.0
ELLSAVRGSRVPIVVHCSAGIGRTGTIVaIEYILER
| ..... ..  ..||| ||| |..|.. | |....
efiekaeqkgkkvlVHCqaGisRSatli.iaYlmkt
DSPc Dual specificity phosphatase, catalytic domain 264-299 1.7e-06 23.0 In-house 64-98 (133) alignment 
Range on Protein: 264-299
Range on HMM: 64-98/133.0
ELLSAVRGSRVPIVVHCSAGIGRTGTIVaIEYILER
| ..... ..  ..||| ||| |..|.. | |....
efiekaeqkgkkvlVHCqaGisRSatli.iaYlmkt
subfamily_CG42327_pd Subfamily CG42327 267-340 2.5e-17 57.5 In-house 241-314 (319) alignment 
Range on Protein: 267-340
Range on HMM: 241-314/319.0
SAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNY
|. | |. |.||||| |.||||...| .  .... |.|.   .|.|| |.| .|| ...|  || .|..|. .|
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_PTPN9_pd Subfamily PTPN9 274-344 4.2e-21 70.2 In-house 224-293 (297) alignment 
Range on Protein: 274-344
Range on HMM: 224-293/297.0
VPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEK
 ||||||||||||||| ..... |.|. |  ..  . . || || |||.||||. || . .  .|.| ||.
PPivvhcsaGiGrtGtfitldiclsrleevgtvd.vvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 274-342 6.2e-12 39.9 In-house 263-345 (350) alignment 
Range on Protein: 274-342
Range on HMM: 263-345/350.0
VPIVVHCSAGIGRTGTIVAIEYILE------RIAE--------NKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYFL
 ||.||||||.|||||.|.....|.       . .        .|   ..  .|. || ||   .|.  |...|.  .|.|| 
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 274-341 6.3e-08 26.3 In-house 266-344 (349) alignment 
Range on Protein: 274-341
Range on HMM: 266-344/349.0
VPIVVHCSAGIGRTGTIVAIEYILE--RIA---------ENKQCPPMPDLVKSLRDQRAYSIQTDMQYLYIHRVMLNYF
 ...|||||| ||||..| ....|.              ....  ..   | .|| ||   .|   |.  |.  .|.||
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 276-337 9.7e-09 29.5 In-house 1-61 (69) alignment 
Range on Protein: 276-337
Range on HMM: 1-61/69.0
IVVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVM
.|||||.| |||||..||   . ||  .|    . . |. .|  |   .  ...|..||  .
mvvhcssgtgrtgtfiaimvemarikseklvd.ifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 277-337 5.6e-08 27.0 In-house 1-60 (69) alignment 
Range on Protein: 277-337
Range on HMM: 1-60/69.0
VVHCSAGIGRTGTIVAIEYILERIAENKQCPpMPDLVKSLRDQRAYSIQTDMQYLYIHRVM
|||||.| ||||| .||   . ||  .|    . . |. .|  |   .  . .|..||  .
vvhcssGtGrtGtfiaimvemarikseklvd.ifnnvqymrkcrpmmvmneneymfihdal