Gene C17H12.5 in Caenorhabditis elegans

Synonym: CELE_C17H12.5, CELE_C17H12.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP020_AA protein Get Run
CeleP020_AA_128-411 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 120-416 4.5e-52 172.7 In-house 9-305 (308) alignment
Range on Protein: 120-416
Range on HMM: 9-305/308.0
QAMDAPATTKTAVKPTKWKAEDVAVAYIQKLDPGVIRAEYIEACAATKvNIDKDCQLWKKNLQMNQADNYPILDSTIVKNpAQPDSYVNMSSVIVP--HC
. . .   |.. |. .|.  .|.. .. ..||.| ...|. | .. .  ... .. |...|  .|.  .....|.. ||   ....|.| | | ..  ..
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgysskl

RYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEK----NDFFPTTMG-AYVYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSNSVMMNVYVHT
.  ....| |. .  | |||  ... | .  .|. ... .      ..|...|  ...|| ..|.....|. ... |..|.|. ..| ..| ..... .|
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhyt

GWEASGVPVRyantTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
.|.  |||      .....| ...|..| . ....| ...|.||.| |. |  ....|. . .. . |.|| .|.|||..| .  ||  .| . ..|.|.
nWpdhgvPps....peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

KITI
|.|.
kltk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 125-402 4e-13 43.7 In-house 12-275 (290) alignment
Range on Protein: 125-402
Range on HMM: 12-275/290.0
PATTKTAVKPTKWKAEDVAVAYIQKLDPgVIRAEYIEacaatKVNIDKDCQLwKKNlqmnQADNYPILDST-IVKNPAQPDSYVNMSSviVPHCRYPILM
 |  | | . .| .....|. |..|| |  . ..|.|     .  .||. .. |||    .  . .  | | .. .  ..  ||      |   . ....
eafekfasdvvkknvdelakeyleklkp.ylpvqyle.....rkifdkntef.kkn....rykdvvcndktrvilkdGydGdyvhany..vkGlkamfil

AQMPKRGFEEEFWRAAFNESVVIMYVLMG-TEDE---KNDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGV
.| . .    ..||   .| |  . .|    ||     ....| . |  . .|.. |   . .. |..  . |. |       . ... .    |    |
tqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv

PvryaNTTRSVVDVMNFVKTSSGTekMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASI
.    ..| ... ..  ... ||   . |    | ||.| | .. ..  .| |  | .. ..|.|.|  | |.|.   ||  .
a....lstlallrtlrilrkasGp..vvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylal

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 129-425 1.1e-126 416.4 In-house 2-300 (302) alignment
Range on Protein: 129-425
Range on HMM: 2-300/302.0
KTAVKPTKWKAEDVAVAYIQKLDPGVIRAEYiEACAATKVNIDKdCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPK
|......||..|..|......|| . ...|. ......||...| |...||||..||....|||||..||..|.||||||.|.| ||.....|..||.||
kveeekekWveeeeakklvksldtaevkkef.kkidtmkvdlek.CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpk

RGFE---EEFWRAAFNESVVIMYVLMGTEDEKN---DFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVR
...|   |||||..|.|..| ...|.|.|. |.   ..||...|.|..||.||||.|||||..||.|||.|||||.|.||||..||||.| |... |||.
vdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvk

YANTTRSVVDVmnFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITIPEGMQQ
||........|  |.|.....|....|||||.||||.||.| .|...|....||.| ||||.||||||.||||.|||.|.|.....|||||.| ||....
yaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkk

KFD
|..
kee

0039614 (Phosphotyrosine protein) phosphatases II 131-416 2.6e-46 153.8 In-house 10-295 (297) alignment
Range on Protein: 131-416
Range on HMM: 10-295/297.0
AVKPTKWKAEDVAVAYIQKLDPGVIRAEYIEACAATKvniDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQP-----DSYVNMSSVIVPHC-RYPILMA
 . |......|... ............|. | .  .    |. . |...|  .|.  .....|.. ||    .     ..|.|.| | ....    ....
esipiplsvldlllllekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKN---DFFPTTMGayvYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSnsVMMNVYVHTGWEASGVPV
| |  .  | |||  ... | .   |. ... ..   ...|...|   .|| ..|. .|||. ..  |..|.|| .|| |   ..... .|||   ||| 
qgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnnges..rtvthfqytgwpdhgvpp

RYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITI
  .   . .  |......... ...|| ...|.||.| |. .  ....|. . .. . |.|| .|.|||.|| .  ||  .| . ....|.| |.
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkltl

0040438 (Phosphotyrosine protein) phosphatases II 136-423 1.1e-48 161.5 In-house 1-289 (317) alignment
Range on Protein: 136-423
Range on HMM: 1-289/317.0
KWKAEDVAVAYIQKLDPGVIRAEYIEACAATKVniDKDCQLWKKNLQMNQADNYPILDSTIVK----NPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGF
|.. .. |. .. |.| .... |... .  ..   . .. ....| ..|.  .....|.. ||    ..  ...|.|.| | .|...  ....| |. . 
kvldlllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpnt

EEEFWRAAFNESVVIMYVLMGTEDEKN----DFFPTtmGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVryanTT
 | |||  ... | .   |. .|. ..     ..|.  | ...|| ..|.....|. ... | .|.|| ..| |.|...... .|||   |||     ..
vedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp....sp

RSVVDVMNFVKTS--SGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITIPEGMQQK
....| ...|...  .. ...|| ...|.||.|.|. .  ....|. . .. . |.|| .|.|||.|| .  ||  .| .  .|.|.|.| .. ...|
dllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselk

0043336 (Phosphotyrosine protein) phosphatases II 136-411 4e-43 143.2 In-house 3-278 (278) alignment
Range on Protein: 136-411
Range on HMM: 3-278/278.0
KWKAEDVAVAYIQKLDPGVIRAEYIEACAATKvnIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQP----DSYVNMSSVIVPHCRYPILMAQMPKRGF
..|    |.... . .. ....|. | .  ..  ..... |...| ..|.  .....|.. ||    .    ..|.| | | ....   ....| |  . 
svkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

EEEFWRAAFNESVVIMYVLMGTEDEKN----DFFPttmGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTT
.| |||  ... | .  .|.. .. ..     ..|   | ...|| ..|. .|.|. ..  |..|.|| ..| ..| . ..| ..||   |||   .   
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

RSVVDVMNFVKtsSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
. . .|.....  .  ...|| ...|.||.| |. |  ....|... .. . |.|| .|.|||.|| .  ||  .| .  .|.|
dflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleylk

0045450 (Phosphotyrosine protein) phosphatases II 138-412 1.3e-41 138.7 In-house 12-306 (307) alignment
Range on Protein: 138-412
Range on HMM: 12-306/307.0
KAEDVAVAYIQKLDPGVIRAEYIEACAATKV-NIDKDCQLWKKNLQMNQADNYPILDSTIVKNPA-----QPDSYVNMSSV--------IVPHCRYPILM
.  . .|.. .. ..  ...|. . .  |.  ... .. |...|  .|.  .....|.| ||        ....|.|.| |         ....   ...
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

AQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKN----DFFPTTmGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPN-GFSNSVMMNVYVHTGWEASG
.| |. .  |.|||  ... | .   |..... ..     ..|.. | ...|| ..|. ...|. ... |..|.|| .. | ..| . ... .|||   |
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhg

VPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSE---PRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
||   . . . .  |......... ...|| .. |.||.| |. .  . ..|... .   . . |.|| .|.|||.|| .  ||  .| .  ....|
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk

0036941 (Phosphotyrosine protein) phosphatases II 141-422 4.1e-53 176.0 In-house 1-289 (297) alignment
Range on Protein: 141-422
Range on HMM: 1-289/297.0
DVAVAYIQKLDPGVIRAEYIEAcAATKVNIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAF
|... ....|..  .. |. |     .........|...||..|.  .....|.| || . ....|.|.| | .... . ....| |. .  |.|||  .
dllkllekllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

NESVVIMYVLMGTEDE----KNDFFPTTMGAYVYYGAMFVNIRKVEKM-DEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMN
.. | .  .|   ..        ..|...| ...|| ..|. ..||.. ... |..|.||...| ..| ..... .|||   |||  .|   . .  | .
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

FVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLN---DNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITIPEGMQQ
. | . . ...|| ...|.||.| |. .  ....|.    . .. | |.|| .|.|||.|| .  ||  .| .. ...||| |... ...
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl

subfamily_PTPN9_pd Subfamily PTPN9 144-413 1.1e-10 36.0 In-house 7-293 (297) alignment
Range on Protein: 144-413
Range on HMM: 7-293/297.0
VAYIQKLDPGVIRAEYIEACaATKVNIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPD----SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAA
|||... .   .. ||.|   ...|.   ...  . ||. |.  .   .|.| |. . ...     |.| . |   . .  .. .| | .   ..|||  
vayvkekgkrGlskeyaeir.nepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

FNESVVIMY-VLMGTEDEK---NDFFPTTMGAYVYYGAMFVNIRKVEKM-DEERTRYTIEVLPNGFSNSVMmnVYVHTGWEASGVPVRYAN------TTR
....|...  .    |  .   . ..|.. ..   .| . |.  .||.. | . . ..|.   .. | .|.   .  ..|   |||   |.      . |
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvt..hfqflsWPdyGvPssaaslldvlekvr

S-----VVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
.     | .. .  |       ..|    | ||.| | .|  .   |.. .   . | || .|.||  ..   .||.  ||. . | ...
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel

0051299 (Phosphotyrosine protein) phosphatases II 146-411 1.3e-39 131.8 In-house 16-287 (288) alignment
Range on Protein: 146-411
Range on HMM: 16-287/288.0
YIQKLDPGVIRAEYIEACAATKVnIDKDCQLWKKNLQMNQADNYPILDSTIVKNPA----QPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFN
.... ..  ...|. | .. .   ..  . |...||. |.  ... .|.. ||        ...|.| | . ....    ...| |. .  |.|||  ..
kllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvwe

ESVVIMYVLMGTEDEK----NDFFPTtmGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPN----GFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDV
. | .  .|..... .      ..|.  | ...|| ..|.....|. ... | .|.|| ..    | ..| . ... .|.|   |||       . . .|
qnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

MNFVKtsSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
... .  ||   ..| ...|.||.| |. |  ....|. . .. . |.|| .|.|||..| .  ||  .| . ..|.|
rkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk

subfamily_PTPN14_pd Subfamily PTPN14 147-412 3.2e-14 47.6 In-house 17-298 (300) alignment
Range on Protein: 147-412
Range on HMM: 17-298/300.0
IQKLDPGVIRAEYiEACAATKVNIDKDCQLWKKNLQMNQADN-YPILDSTIVKNPAQP--DSYVNMSSVIV--PHCRYPILMAQMPKRGFEEEFWRAAFN
 .||. | . .|| |  .  . . . ..   ..| . |.  .  |  |. .  .|..   . |.| ||. |     ..  ..|| | .   ..||.  ..
ekkleegkvftey.eripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

ESVVIMYVLMGT-EDEK---NDFFPTT--MGAYVYYGAMFVNIRKVEKMDEERTR-YTIEVLPNGFSNSVMMNVYvhTGWEASGVP------VRYANTTR
. | ..  |  . || |     .|| .      | .|   |  . .|. |   |. .... || .   .|..  |  | |   |||      . | .  .
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevq

SVVDVMNFVKTS-SGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
||   .|  . | .    .||   .| ||.|  .       .|. | |  | .... .| ||   |... ||  .|   . |.|.
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

0047943 (Phosphotyrosine protein) phosphatases II 148-411 1.2e-47 158.0 In-house 7-273 (273) alignment
Range on Protein: 148-411
Range on HMM: 7-273/273.0
QKLDPGVIRAEYIEACAATKvNIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIM
..|.......|. . .  .. .... . |...|...|.  .....|.. || . ....|.| | | ....   ....|.|. .  |.|||  ... | . 
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

YVLMGTEDEK----NDFFPTTMGA-YVYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSSG
 .|. ... .      ..|...|  ...|| ..|.....|. ..  | .|.|. ..|...| ..... .|||   |||  ..   . . .|... ... .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

TEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
 ....| ...|.||.| |. |  ....|. . .. . |.|| .|||||..| .  ||  .| ....|.|
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleylk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 151-410 9.1e-09 29.3 In-house 20-279 (303) alignment
Range on Protein: 151-410
Range on HMM: 20-279/303.0
DPGVIRAEYIEACAATKVNIDKDcqLWKKNLQMNQADNYPILDSTIVKNpaQPDSYVNMSSVIVPHCRYPILmAQMPKRGFEEEFWRAAFNESVVIMYVL
|  .   |. . ..    .. |.   . ||.. |.  .   || . ||      ||.  | . .   .  || .|.|      .||.   .. |  . .|
daniavnefekvvsylppsvskn..qfvknmdknrfvdvicldhskvkl..sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlll

MgTEDEKN-----DFFPTTmGAYVYYGAMFVNIRKVEKMDEeRTRYTIEVL--PNGFSNSvMMNVYVHTGWEASGVPVR-YANTTRSVVDVMNFVKTSSG
. |. | .       ||     .. .   .. . .  ...     ... ||   ||  .| .. |. .  |  . .|    ..  . . ..  ...  | 
l.tdseydklggdsvfprn.qdflkfeersirvgefkrvel.gdgwvlkvlsvsngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd

TEKMLVVSKNGCGRAGFFLSLGAAFCCLND-NSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYI
..  . .|  |||||| |  . .|   | . ..   .   .. .|  |  ||. . |.. .|  .  ..
stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 155-408 9.7e-16 52.9 In-house 36-289 (319) alignment
Range on Protein: 155-408
Range on HMM: 36-289/319.0
IRAEYIEACAATKVNIDKDCQLWKKNLQMNQADNYPILDSTIVKNP----AQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVViMYVl
...|.  ||  .    |..    ..|   |.  |    | ..||       .   |.| | |     .   . || |.    ..|||  ..  .   .| 
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs.tiv.

MGTEDEKNDFFPTTMgaYVYYGAMFVNIRKVEKMDEeRTRYTIEVLPNGFSN-SVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSSGTEKMLVV
. |.|   ...|  .   . .. . |..  ||. .|  .   ||.  .|  .    .. .   ||   |||   ..  | |  |  . .   . ....| 
lltkdkcsqywplki..vikeerfkvkvdsveetae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvh

SKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVY
   |.||.| .. | . .  .....   . ..|. .| ||.. |... ||  ||  .. 
csaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

0046845 (Phosphotyrosine protein) phosphatases II 156-417 5e-44 146.2 In-house 3-281 (284) alignment
Range on Protein: 156-417
Range on HMM: 3-281/284.0
RAEYIEACAATKVNI-DKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPD-----SYVNMSSVIVP-----HCRYPILMAQMPKRGFEEEFWRAAFNESV
..|. | .  |   . . .. |...|| .|.  .....|.. ||    ..     .|.| | | ..     ...  ....|.|. .  |.|||  ... |
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

VIMYVLMGTEDEK----NDFFPTTmGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPNG-FSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKT
 .  .|..... .      ..|.. | ...|| ..|.....|. ..  |..|.|. ..|  ..|...... .|.|   |||   ..  . . .| .. . 
rvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

SSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNS---EPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITIP
..| ....| ...|.||.| |. |  ....|. ..   .. . |.|| .|.|||..| .  ||  .| ....|.|.|.|..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 158-411 1.7e-18 61.8 In-house 27-284 (305) alignment
Range on Protein: 158-411
Range on HMM: 27-284/305.0
EYIEACAAtKVNIDKDCQLWKKNLQMNQADNYPILDSTIV-KNPAQP-DSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLM----
.| . .   .  || ...  .|. . ... ..   | .|. ... ..   |.| | |   . .   ..|| | .   ..|||  ..| |. .  |     
qykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

GTEDEKNDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPvRYANTTRSVVDVMNFVKTSSGTEKMLVVSK
| .|  . ..|....  . .| . |...  ... .  .|       .. ..|  .  |  | |   ||| ..| .  |... ..  . ..    .||.  
ggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvp.qfatsllslikrvqkdqkkdkgvpllVhCs

NGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
.| ||.| |...  |.  |.   .  . |..|..||.|...| . .|| ...     .|.
agvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

DSPc_SM00195 161-411 1.3e-44 147.9 In-house 8-263 (263) alignment
Range on Protein: 161-411
Range on HMM: 8-263/263.0
EACAATKVNiDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQ----PDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE
.  ..|. . ..... .||| ..|.  |... |.| || . .    ...|.| . . .....  . ..|.|.    |.|||  ..| | | ..|.  |..
kleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

----KNDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSSG--TEKMLVVS
     ....| ..| .  .| . |....|||...| ...|.|.  .| ...  ...| ...|. .|||    ..|.||......||.|.   .. ..|..
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp....dstksvlellravkkskstssgpivVhC

KNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
..|.||.| |...  .   |...... | ||||..|.|||..|.. .||. || ....|||
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik

PTPc_SM00194 161-411 1.3e-44 147.9 In-house 8-263 (263) alignment
Range on Protein: 161-411
Range on HMM: 8-263/263.0
EACAATKVNiDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQ----PDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE
.  ..|. . ..... .||| ..|.  |... |.| || . .    ...|.| . . .....  . ..|.|.    |.|||  ..| | | ..|.  |..
kleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

----KNDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSSG--TEKMLVVS
     ....| ..| .  .| . |....|||...| ...|.|.  .| ...  ...| ...|. .|||    ..|.||......||.|.   .. ..|..
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp....dstksvlellravkkskstssgpivVhC

KNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
..|.||.| |...  .   |...... | ||||..|.|||..|.. .||. || ....|||
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 167-412 1.9e-15 51.7 In-house 35-285 (319) alignment
Range on Protein: 167-412
Range on HMM: 35-285/319.0
KVNIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPD----SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKNDFFP
 || . |    ..| . |.  |    | | |. .. ..     |.| | .   . |   . .| |.    |.|||  ..| . |. .| .  .. . .. 
avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklk

TT--MGAYVYYGAMFVNIRKVEKMDEERT-RYTIEVLPNGFSNsVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSSGT---EKMLVVSKNGCGR
 .     .. || . |.. . |....    . ... . .      ..  . .| |   .||    ....|..|... .. |        . |   .| ||
kywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvP....ekatslldllkrirksrektqsgPivvhCsaGvGR

AGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
 | |. | |..  .. ..   . ..|. .| ||.  |.  .||  ||   . ... 
tGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 167-412 7.6e-15 49.5 In-house 39-285 (290) alignment
Range on Protein: 167-412
Range on HMM: 39-285/290.0
KVNIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMG-TEDEK---NDFFP
.|.. .. .| ..  ..   |.. |    | ...  ...|.| . .   . ..  ...| |      .||.   .|.| |. .|.  .|..|   . ..|
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp

TTmGAYVyYGAMFVNIRKVEKMDeERTRYTIEVLPNGF-SNSVMMNVYVHTGWEASGvPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFL
.. ..   || . ... . |... | .. ..||  .    .. ..  |  | |.  |  |   .|  .|.  |.  .  .| . ..|   .. ||.. |.
ds.dtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfc

SLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
..  .    . .    . ...|  |.|.|. | . .||  |.  .. |...
aaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 168-411 4.2e-11 37.1 In-house 34-294 (301) alignment
Range on Protein: 168-411
Range on HMM: 34-294/301.0
VNIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE----KNDFFPT
|..... .  ... .... |.  |. ..  .   .  .|.| | .     .    .|| | .    .|||  ..| .| . ........     . ..|.
vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpn

TMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNS--------------VMMNVYVHTGWEASGVpVRYANTTRSVVDVMNFVKTSSGTEKMLVV
.     ..| . | . .   . .   |    .. .|..|.                .  .  | |   || ||  .|   |.| .   . . |  ...| 
seaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv.vreprtvLqviddvihrqqkigggpvvVH

SKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
  .. .|.| . |.  .      .    . ...||.| ..| ||  ..|| |||     |..
CSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

0045098 (Phosphotyrosine protein) phosphatases II 169-412 1.6e-21 72.3 In-house 22-274 (278) alignment
Range on Protein: 169-412
Range on HMM: 22-274/278.0
NIDKDCQLWKKNLQMNQADNYPILDSTIVKnpaqpDsYVNMSSVIVPhcRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEK----NDFFPTt
. .  . |. .|| .|   ... .|.. ||     | |.| | . ..  .   ...| |.    . |||  ... . .   |.. .. .      ..|  
pseitpalylgnldknRykdilpydhsrVk.....d.YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

mGAYVYYGAMFVNIRKVEKMdEERTRYTIEVLPN----GFSNSVMMNVYVHTGWEASGVPVRY--ANTTRSVVDVMNFVK-----------TSSGTEKML
 | ...|| ..|.. ..| . .. |  |..|           |  ....  ..|.  |||     .   . .  . ...|           . .. ...|
.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VVSKNGCGRAGFFLSLGAAFCCLndNSEPRIGEIVKAIRSQRPN-AVDSIKQYASIYLCFVYYIKK
|  . |.||.| .  .    ..|  ..   . |.|| .|||||. || .  ||  .| . ......
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 169-402 3.5e-12 40.8 In-house 22-258 (283) alignment
Range on Protein: 169-402
Range on HMM: 22-258/283.0
NIDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPH---CRYPILMAQMPKRGFEEEFWRAAFNESV---VIMYVLMGTEDEKN-DFF
. | |..  ..| ..|. ..    |  .|.  ... .|.| . ..| .        ..|| | .    .||.  |.| .   |..  |.  ...|   ..
dldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PtTMGAyVYYGAMFVNIRKvEKMDEERTRYTIEVLPNG-FSNSVMMNVYVHTGWeasgvpV-----RYANTTRSVvdvmNFVK---TSSGTEKMLVVSKN
|   |. . || . | .|| |   .  ..  . .  |.   .....  |   .|      .        |.   .    | |.   | |    ..|   .
P.krGs.edyGeftvtlrk.ettsnsfiikelllrvnssakstlllahyqvidW......leygeqaiinslvkf....nkvislqteskkgPivvhCst

GCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASI
| ||.. |... |.   .  .|   . ..|| .| ||. || .  ||  .
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv

subfamily_PTPN23_pd Subfamily PTPN23 170-412 3.5e-18 60.4 In-house 33-282 (288) alignment
Range on Protein: 170-412
Range on HMM: 33-282/288.0
IDKDCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSV--IVPHCRyPILMAQMPKRGFEEEFWRAAFNESVVIM-YVLMGTEDEKN---DFFPT
 .. . . |.. . |.  .    |.. ||   . | |.| | |  ..| |  .....| |...   .||.  ... . ..  .|  .| .|.    ..|.
rkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

TMGAYVYYGAMFVNIRKVEKMDeERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMN-FVKTSSGTEKMLVV-SKNGCGRAGFFL
  |. | .|.. | ...|.... .  ......  .. ..  ..     | |   |||    .  . .  | . . ..   ... |||    | ||.| | 
dkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

SL-GAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
 . .|.    ..|  . | ..|. .| || . |   .|.   |   . ....
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

0040439 (Phosphotyrosine protein) phosphatases II 172-412 1e-37 125.5 In-house 3-248 (249) alignment
Range on Protein: 172-412
Range on HMM: 3-248/249.0
KDCQLWKKNLQMNQADNYPILDSTIVKNPA----QPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE----KNDFFPT
... |...|. .|.  .....|.. ||        ...|.|.| . ....   ....| |  .  | |||  ... . .   |. ..         ..|.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

tmGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSL
  | ...|| ..|. ..||.  .. |..|.|. ......|.. ... .|.|   |||   . . . .  |...... .  ...|| ...|.||.|.|. .
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

GAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKK
  ....|. . .  . |.|| .|||||.|| .  ||  .| .  ....|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk

subfamily_PTPN13_pd Subfamily PTPN13 172-411 2.7e-13 44.8 In-house 27-270 (273) alignment
Range on Protein: 172-411
Range on HMM: 27-270/273.0
KDCQLWKK--NLQMNQADNYPILDSTIVKNPAQPDsYVNMSSVI--VPHCRYPILMAQMPKRGFEEEFWRAAFNE-SVVIMYVLMGTEDEK---NDFFPT
..|.  ||  | . |.  |    | | ||  ..   |.| | .   | . .|  ...| |     ..||.  ..  . ||. | .  |..|   . ..| 
dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

TMGAYVYYGA-MFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDvMNFVKTSSGteKMLVVSKNGCGRAGFFLS
...  .     . |.  ||.|.|.   | ...|  .  ..|  .     . |   |||   |.  . |   .. ..|..|   ..|    | ||.| ...
sknkklkvsnrlevellkvqkldgfvvr.alavkdsesgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqtdag..PivvhcsaGiGrsGtlit

LGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
. ...  .. . |  . |||. .| ||   | . .||  .|  ... .|
idvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

0042113 (Phosphotyrosine protein) phosphatases II 173-411 9.9e-35 115.5 In-house 2-244 (245) alignment
Range on Protein: 173-411
Range on HMM: 2-244/245.0
DCQLWKKNLQMNQADNYPILDSTIVKNPAQP----DSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKN----DFFPTt
...|...| ..|.  .....|.| || .  .    ..|.|.| | ....   ....| | ..  | |||  ... . .   |. .|. .      ..|. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

mGAYVYYGAMFVNIRKVEKmDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKT---SSGTEKMLVVSKNGCGRAGFFL
 | ...|| ..|. ...|. ... |..|.|| ..| . | . ..| ...|.  |||    .......|...||..   ... ...|| .. |.||.| |.
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvp....dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

SLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
 .  ....|. . .  . |.|| .|||||.|| .  ||  .| .  ...|
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

0037934 (Phosphotyrosine protein) phosphatases II 173-410 2.5e-21 71.8 In-house 3-242 (243) alignment
Range on Protein: 173-410
Range on HMM: 3-242/243.0
DCQLWKKNLQMNQADNYPILDSTIVKNpaQPDSYVNMSSVIVPHcRypILMAQMPKRGFEEE----FWRAAFNESVVIM-YVLMGTEDEKNDFFPTTMGA
 . |.. ||  |.  ... .| . ||   ....|.| . . |.  |  .   |.|  .  |.    |||  ... . .   .   .| .... ..   | 
siallpenlsknrysdilpydhsrvkl..egsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

YvYYGAMFVNIRKVEKMDEeRTRYTIEVLPNG-FSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKT------SSGTEKMLVVSKNGCGRAGFF
. .|| ..|.. ..| .|.  | .|... . .    . .   | ...|   |||   ..  . . .| .|..        .. ...||  . |.||.| .
v.tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

LSLGAAFCCLndnsEPRIGEIVKAIRSQRPN-AVDSIKQYASIYLCFVYYI
. .     .|    .  . |.|| .|.|||. || .  ||  .| .  ...
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 173-411 1.2e-13 45.7 In-house 26-260 (267) alignment
Range on Protein: 173-411
Range on HMM: 26-260/267.0
DCQLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVL-MGTEDEKNDFFPTTMGAYVYY
 . . .|| ..|. |.    | |.|    . . |.| | |   . .   .. | | .    .|.    .. | .. .| .  .|. . |.|  ||    |
sqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakky

GAMFVNiRKVEKmdeERTRYTIEVLPNGFSNSVMMNV--YVHTGWEASGVPVRYantTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCC
  . |. . .||   |   | | .|   | |    ||  | .  |.       |    . .. ..   .   |   ..|  ..| ||.| || . . .  
qdltve.hslek...eendyqiitlelkfknesahnvtlyyykkwnintnnkpy...lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqler

LNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
.  ..   | . .. |||||.  ||.  .|  |.  .. | .
aktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 175-413 1.1e-15 52.4 In-house 38-274 (288) alignment
Range on Protein: 175-413
Range on HMM: 38-274/288.0
QLWKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSsvIVPHCRY--PILMAQMPKRGFEEEFWRAAFNESV---VIMYVLMG-TEDEKNDFFPTTMGAY
. . .|   .. .| |  | | ||    || |..    .|.  .|   .. || | .|  ||.|.  ... |   |..  |.    .. ...||. .|  
dsfianptrdryenlprcditrvklsddpdfyiaan..vvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

VYYGAMfVNIRKVEKMDEERTR-YTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRsVVDVMnfvktSSGTEKMLVVSKNGCGRAGF-FLSLGAA
. .| .  .. |... | ...   ..    .   ..|.. .     |.  |||  |    | ...|.      | .. ..| |..| ||.|   |.| |.
arigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr.llevl.....kslqkPivvhssaGvGrtgtlililial

-FCCLNDNSepRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
   .|.|..   | ....  | .| .|. . .||  .. |  ...  |
eslrlddfl..girsllaklreerfkaiqtemqylyvhrcvleelllk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 177-411 1.4e-24 81.8 In-house 54-290 (325) alignment
Range on Protein: 177-411
Range on HMM: 54-290/325.0
WKKNLQMNQadNYPILDsTivKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAA--FNESVVIMY-VLMGTEDEKNDFFPTTMGAYVYYGA
.|  . ...  . ..|  |  |. .    |.| | .     .   | ||.|.    ...|| .  .. |||..  .| . .|.   ..|  ||  . .|.
fknvvaldk..srvvle.t..kkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGg

MFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVP---VRYANTTRSVVDVMNFVKT-SSGTEKMLVVSKNGCGRAGFFLSLGAAFCC
. |..| .|.. .   |  ..|      ..  .. . . .|.  ||.      .. .. |  | . |.. . ..  .||   .| ||.| |.|| .|   
levklrtieeisdyvhr.vldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalak

LNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYI-K
. ..|.  | . || .| .||. |... ||  || ..| ..  
vieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_PTPN3_pd Subfamily PTPN3 177-405 7.1e-13 43.1 In-house 38-270 (280) alignment
Range on Protein: 177-405
Range on HMM: 38-270/280.0
WKKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCR----YPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGT-EDEK---NDFFPTtMGAY
  .||. |.  .    |.| ||  ...  |.| . | .           . .| | .   ..||.  ..... .. .|  . |. .     ..|. ..  
kpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tede

VYYGAMFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVktSSGTEKMLVVSKNGCGRAGFFLSLGAAFC
. || . |...| ..  .  .|  . .  .  ... ..    .. |  .|||   |.  . |  | .    |. .| ..|    | ||.| .. |  |..
leygefsvkcekedetksyvlr.elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCsaGigrtGvlilletala

CLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLC
 .. . .  . .||. .| || . |.. .||  .  .
lieaaepvypldivrtmrdqramlvqtasqykfvCea

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 177-413 1.7e-08 28.4 In-house 52-292 (305) alignment
Range on Protein: 177-413
Range on HMM: 52-292/305.0
WKKNLQMNQADNYPILDSTIVK--NPAqPDSYVNMSSV---IVPHCRYpiLMAQMPKRGFEEEFWRAAFNESVVIMYVLMGT-E--D-EKNDFFPTTMGA
 . .   |. .. |  | ..||  .|. |  |.    |   ..|. |.  . || |     .|||    .. |  . .|  | |       ...|...| 
adiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrf..icaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

Y--VYYGAMFVNIRKVEKMDEErTRYTIEVLPNGFSNSVMMNVY--VHTGWEASGVPVryanTTRSVVDVMNFVKTSSgtEKMLVVSKNGCGRAGFFLSL
   .  | .  |.     |. . .   | .|   .| .  | |     | |   |||        . ....  .. |     ..|    | ||.|  ...
klelksgivvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewpdrgvpp....ckltslellsairgsk..vpivvhcsagigrtgtivai

GAAFCCLNDNSE-PRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
   .  . .| . | . |.|||.| ||  ....  ||  |.  .. |. .|
eyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

subfamily_PTPRN_pd Subfamily PTPRN 177-407 1.9e-07 25.1 In-house 53-289 (297) alignment
Range on Protein: 177-407
Range on HMM: 53-289/297.0
WKKNLQMNQADNYPILDSTIV----KNPAQPDSYVNMSSVIVPHCRYPILM-AQMPKRGFEEEFWRAAFNESVVIMYVLMGTED----EKNDFFPTTmGA
 .||.. |.. .    | ..|    .. |. . |.| |...    | |. . .| |      .||.  ... ||..  |   |.    . . ..| . |.
aeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde.Gs

YVYyGAMFVNIR--KVEKMDEERTRYTIEVLPNgfSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTS-SGTE-KMLVVSKNGCGRAGFFLSL
 || ..  |..   ..   |     . .  | .  |..  .  . .  |...|||     ...|...    |  |  |    ..| . .|.||.| .. .
evy.hiyevhlvsehiwcddylvrsfylknlqt..setrtvtqfhflswpeegvP....asaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

GAAFCCLND-NSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFV
      |.    |  |   .. .| |||. | . .|.  .. . .
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 178-409 1.2e-16 55.7 In-house 48-283 (297) alignment
Range on Protein: 178-409
Range on HMM: 48-283/297.0
KK-NLQMNQADNYPILDSTIVK---NPAQPDS-YVNMSSVivPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMG--TEDEKNDFFPTTMGaYVY
|| |.. ..  |    ||  ||      .||| ||| | |  .  .. ..  |||..   ..||.  ..| | .. .|     .|.|   . .  |  . 
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg.vtt

YGAMFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRyaNTTRSVVDVMNFVKTSSGTEK---MLVVSKNGCGRAGFFLSLGAAF
.| . | .  |..      | ..||  .   .  ... | .. |    |. .  ....|...... |. . ....   .||   .| ||.| .|..    
fGdvsvvllsvsereGfikr.elevtkgkakarrvvkqyqfveWPdkaverk..dsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

CCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYY
.  ... |  | ..|| .| .||. |   .||. .|   . .
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 178-411 3.9e-13 44.0 In-house 45-279 (287) alignment
Range on Protein: 178-411
Range on HMM: 45-279/287.0
KKNLQMNQADNYPILDSTIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMG-TEDEKN---DFFPTTMGayVYYGA
..| . |.  .  . |   |    . . |.| . .   . ..  ..|. |      .||.   .. | .. .|   .|....   ...|..    |..| 
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

MFVNIRKVEkMDEERTRYTIEVLPNG-FSNSVMMNVYVHTGWEASGVpVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLND
  ... . | . .. .  ..||  ..  ..  ... |  | |.  |  |   .|   |.. |.  .  .|   ..|   .. ||.. |..   .    . 
yniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgk.vtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt

NSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
.    . ...|  | |.|..|  ..||  |.   . |..
eGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 179-406 3.5e-11 37.1 In-house 44-232 (392) alignment
Range on Protein: 179-406
Range on HMM: 44-232/392.0
KNLQMNQADNYPILDSTIVKN----PAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLmgTEDEKNDffpttmgayvyygam
 ||. |. .|   .||. ||         . |.| | .   ..    . .|.|.    ..|||  |.| |  . ..  |. .. |               
inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv..tklkegd...............

fvnirkvekmdeertrytievlpNGFSNSvMMNVYVHTGWEASGVPVRyantTRSVVDVMNFVKTSSGTE--KMLVVSKNGCGRAGFFLSLGAAFCCLND
                       .| ..   .  .  | |  ..|| .    | |.. ... ||.  |     ...    | ||.|  .|. .  .  . 
.......................kgddar.tvaqfhftewPdkdvpkh....tssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakk

NSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCF
     . ..|  || .||  |.. .||| || . 
trmvdvfnfvtnirrkrpymvqtkeqyafiygav

Y_phosphatase Protein-tyrosine phosphatase 180-406 2e-40 134.1 Pfam-A 1-233 (235) alignment
Range on Protein: 180-406
Range on HMM: 1-233/235.0
NLQMNQADNYPILDSTIVKN--PAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE----KNDFFPTTMGAYVYYGA
|.. |.  .... |.| ||     .|  |.| . |   .    ....|.|   . |.|||  ..| | . ..|   |..     ....|.... ...|| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MFVNIR-KVEKMDEERTRYTIEVLPNGFSN-SVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSS--GTEKMLVVSKNGCGRAGFFLSLGAAFCC
..|... |... ..| | ...|.  .. .. . ..... .|.|. .|||    ....|..|... |..|.   .....|....|.||.| |..| .....
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCF
|....|. . .||| .|.|||..|.|..||. .| . 
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 180-406 2e-40 134.1 In-house 1-233 (235) alignment
Range on Protein: 180-406
Range on HMM: 1-233/235.0
NLQMNQADNYPILDSTIVKN--PAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE----KNDFFPTTMGAYVYYGA
|.. |.  .... |.| ||     .|  |.| . |   .    ....|.|   . |.|||  ..| | . ..|   |..     ....|.... ...|| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MFVNIR-KVEKMDEERTRYTIEVLPNGFSN-SVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSS--GTEKMLVVSKNGCGRAGFFLSLGAAFCC
..|... |... ..| | ...|.  .. .. . ..... .|.|. .|||    ....|..|... |..|.   .....|....|.||.| |..| .....
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCF
|....|. . .||| .|.|||..|.|..||. .| . 
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 180-410 1.8e-18 61.8 In-house 56-290 (298) alignment
Range on Protein: 180-410
Range on HMM: 56-290/298.0
NLQMNQADNYPILDSTIV-K---NPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTED----EKNDFFPTTMGAyvYY
| . |   ..  |||. |     .  .   |.| | .   . | . ...| |     |.|||   .| .  . .|  .|.    . . ..|..  .   |
nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..ty

GAMFVNIRKVEKMDEErTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRyantTRSVVDVMNFVK---TSSGTEKMLVVSKNGCGRAGFFLSLGAAFC
| . |.... |.. .  .  ...|  .  ... ..    .| |   |||      ..||.|... |.   . .| . ..|   .| ||.| |  . . . 
geitvsllskeefadl.ivrklkvskkkeekerevrqlhftsWpdkgvpen....atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvle

CLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYI
 .. ..   . ..||..| .||.||.. .||. ||     ..
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 180-415 5e-18 60.0 In-house 44-282 (315) alignment
Range on Protein: 180-415
Range on HMM: 44-282/315.0
NLQMNQADNYPILDSTIVKN---PAQPD-SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMY-VLMGTEDEK---NDFFPTTMGAYVYY
| . |. .|   |||. ||      .||  |.| | .   ..    . .|.|..   ..|||  ..| |  .  |    |..|   . ..|   .  | .
nfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvef

GAMFVNIRKVEKMDEERTRYTieVLPNGfSNSVMMNVYVHTGWEASGVPVRYAnttrSVVDVMNFVKTSSGTE--KMLVVSKNGCGRAGFFLSLGAAFCC
|.. |.. ..|   .  .|    |. ..  .|  .  .  |.|   ||. . .    |.. ..  ||.. |..   .||    | ||.| ..|.      
Gsikvellsleadtdgvarkl..vtrks.eesrtvtqfqftewPdkGvdkqts....sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaq

LNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKIT
.....   . ..|| .|..||  | . ..|| ||     ... . |
ikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

subfamily_Ptp69D_pd Subfamily Ptp69D 180-413 2.5e-15 51.4 In-house 48-289 (307) alignment
Range on Protein: 180-413
Range on HMM: 48-289/307.0
NLQMNQADNYPILDSTIVK----NPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKND----FFPTTmgAYVYY
|.  |. ..    |.| ||    |  .  .|.| | ..  . .   ..|| |  .  ..|||   . .| .. .|   .. ...    ..|      | |
nalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqy

GAMFVNIRKVEKMDEERTRyTIEVLPNG-----FSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSsgTEKMLVVSKNGCGRAGFFLSLGAA
| . |.. . ||...   | ...|  ..       .|  .  | .|||. | ||       . .  | .  |..     ..|  ..| ||.| |..|   
gdilvklvseekhsdyiiR.eldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsl

FCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
.  |. . .  | |.|| .||||.  |.|..||  .|  .. |... 
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg

0041856 (Phosphotyrosine protein) phosphatases II 180-416 2e-11 39.3 In-house 1-177 (182) alignment
Range on Protein: 180-416
Range on HMM: 1-177/182.0
NLQMNQADNYPILDSTIvknpaqPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMgtedeKNDF----Fpttmgayvyygamf
||  |   ...  | ..      . .|.| . .. ..    ....| |  .  ..|.|   .. . .   |              .              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywpell..............

vnirkvekmdeertrytievlpngfsnSVMMNVYVHTGWEASGVPVryantTRSVVDVMNFVKTssGTEKMLVVSKNGCGRAGFFLSLGAAFCClndnsE
                             .   |....|.  |||      .....| .. |.     .. ||  . |.||.|..  .    ..     .
...........................erlgiqylylpwpDhgvpd.....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

PRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITI
  . |.|| .||.||..| .  ||  ..|.  .... |.|.
vsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 183-413 3.8e-11 37.6 In-house 44-279 (281) alignment
Range on Protein: 183-413
Range on HMM: 44-279/281.0
MNQADNYPILDSTIVKN---P-AQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMyVLMGTEDEKN-----DFFPtTMGAYVYYGA
 |.  |    | | ||      ..   |.| . |   .     . .| |     ..||.  ....| .. |..  | |..      ..|    . . || 
knrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai.vmvtreieagklkChrYWP.ddnselkygd

MFVNIRKVEKMdEERTRYTIEVlPNGFSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKT---SSGTEKMLVVSKNGCGRAGFFLSLGAAFCCL
. |.  . |.  ..  . ....  .  .... ..   .| |   |||    .||. ...  . |.    ..    ...    | ||.| ...|  ..  .
vtvkstaeeek.atyierkfkl.eresgetreveqlaytaWPdhGvP....attkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkav

-NDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
 ....|  . ..|. .| .|   | .. ||. .|.  . ...|.
eaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 183-426 9e-07 22.9 In-house 51-303 (305) alignment
Range on Protein: 183-426
Range on HMM: 51-303/305.0
MNQADNYPILDSTIVK-NPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDE----KNDFFPTTMGAYVYYGAM---
 |.  .   ||   || ... |  |.    |  |     .. .| |      .||   ... |  ...|    .       ..|..  .  . .      
knrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk

-FVNIRKVEKM-----DEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVryanTTRSVVDVMNFVKTSSGTekMLVVSKNGCGRAGFFLSLGAAFC
  | .   ...      . . . |. |.    ...  .. |    |   |||     .  .......  ..| |   . |    | ||.|  . |   . 
isvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa....adlailellekarpskgp..ivvhcsagigrtgsvvmleyild

-CLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKITIPEGMQQKFDD
  |. .       |.. || || |.... .||  ..  .. |..||  . | ... ...
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeayka

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 183-407 5.7e-06 20.2 In-house 40-266 (281) alignment
Range on Protein: 183-407
Range on HMM: 40-266/281.0
MNQADNYPILDSTIVK----NPAQ-PDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNES---VVIMYVLMGTEDEK-NDFFPTTMGAYVYYGA
 |.  | | || . |.     | .    |.    .  |  .   ...| ||.    .|||  ..|    .|..  .. |. ||  ..||    . . .  
knrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdk

MFVNIRKVEkMDEERTRYTIEVLPNGfsNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSSgTEKmLVVSKNGCGRAGFFLSLGAAFCCLND-
. |.      ...      ...  .|  .. ..  ..   |    ||    ...  .. ..  ... | |   ..    | ||.| ....  |.  .   
lsvsyedst.vnkslvttrlnlsyeg..etrlithwlwkewpdwqvp....essevmlkilrkirars.tpp.vihcsagvgrsgtlmaveialqsihsh

NSEPRIGEIVKAIRS-QRPNAVDSIKQYASIYLCFV
 . | | .||  .|   |  .|....||  |.  ..
ftlpdikqivshlrvtgraasvqtlqqymliwkvll

0049772 (Phosphotyrosine protein) phosphatases II 186-418 3.1e-09 32.5 In-house 58-288 (314) alignment
Range on Protein: 186-418
Range on HMM: 58-288/314.0
ADNYPILDstivKNPAQPDSYVNMSSVIVPhcrYPILMAQMPKRGFEEEF----------WRAAF----NESVVIMYVLMGTEDEKNDF--------FPT
|||. ||.    . | .  .| | | |  .      . .| |.    . |          ||  .    |  .. |     ..|| . .        ...
adnrvilp....glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtplli

TMGAYvyygamfvniRKVEKMDEERTRytiEVL--PNGFSNSVmmNVYVHTGWEASGVPvryanTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFL
 .| .               .| |  .   |.|  |. |.. .    |... ..  ..|     ... . ....|... .  .. ||  | |.||.| |.
ldgng..........neptaadlellk...eelydpelferlg..ikylripvpDgsap.....lledfdeflefieeadkggpvlvHCkaGkgRtgtfv

SlgAAFCCLNDNSepRIGEIVKAIRSQRP-----NAVDSIKQYASIYLCFVYYIKKKITIPE
   ||....  .    . |... .|..||     ... . .||  |. .  .|.|.... .|
v..aaylmkllgv..sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkfye

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 186-411 2.5e-08 28.0 In-house 45-278 (287) alignment
Range on Protein: 186-411
Range on HMM: 45-278/287.0
ADNYPILDS--TIVKNPAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMY-VLMGTEDEKND---FFPTTmGAYVYYGAMFVNIR
||  || |.   ..... .  .|.|   |   .     . || |      .|||| ... .  .  .    |. ..    ..|      .  |   | . 
advlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvll

KVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDV---MNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEP
. .... | .  .. ..     .. ... .    | . ...       | |.||   ..  . .|..  ..|  . | ||.| .|.. .    |.|  . 
dydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrv

RIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
 .  .|  .| .|   | .. |.  .|  .| | |
dvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 192-410 1.7e-18 61.7 In-house 21-242 (250) alignment
Range on Protein: 192-410
Range on HMM: 21-242/250.0
LDST-IVKNPAQ---PDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNE---SVVIMYVLMGTEDEKNDFFPTTMGAyvYYGAMFVNIRKVEKM
|||. .| .. .      |.| | . . . |   ...| |     |.|||  ..|   ..|..  |  .| . ....|.       || . |.. . |..
ldssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae..kyGdvtvsllskeef

DEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVPVRYanttRSVVDVMNFVKTSS---GTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEI
 .  .| .. .  .  ......  . .. |   |||  .    ..|..... |..|    |.  ..|   .| ||.| |. . | .  |. .    . ..
adytkr.klklskakkaderivrqlhfvvWPdkgvPeva....tavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkv

VKAIRSQRPNAVDSIKQYASIYLCFVYYI
.|..| .||.||.| .|| ..|     ..
ikvlrkdrphavesleqyvfvyeiilkal

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 193-411 2.1e-18 60.7 In-house 56-277 (515) alignment
Range on Protein: 193-411
Range on HMM: 56-277/515.0
DSTIVKN---PAQPD-SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMY-VLMGTEDEKN---DFFPTTMGAYVYYGAMFVNIRKVEKm
||. ||      .|.  |.| | .   ..    . .|.|..   ..|||  ..| |  .  |    |..|     ..|   |  | .| . |..  .|  
dsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea.

DEERTRYTIEVLPNGFSNSVmmNVYVHTGWEASGVPVRyantTRSVVDVMNFVKTSSG--TEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIV
. . .. ...|| .  |. |    .  |.|   ||| .    |.|.. ..  ||.. |  |  ...    | ||.| ..|.       ..     . ..|
ctggikrkltvlkgddsrtv..tqfhfteWPdkGvpkh....tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfv

KAIRSQRPNAVDSIKQYASIYLCFVYYIK
. || .||  |    ||| ||     ...
tnirqkrpylvqtqeqyafiygavledll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 194-410 3.2e-08 27.9 In-house 49-270 (285) alignment
Range on Protein: 194-410
Range on HMM: 49-270/285.0
STIVKNPAQPDSYVNMSSVIVPHCR-YPILMAQMPKRGFEEEFWRAAFNESVVIMY---VLM-GTEDEKNDFFPTTMGAYVYYGAMFVNIRKVEKMDEER
 | |    .   |.  | . .|       . .| |      .||.  ..| .  .     |. |  ..   ..|  .|  | .|   . . ....     
etrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiag

TRY---TIEVLPNGFSNSVMMNvYVHTGWEASGVPVryaNTTRSVVDVMNFVKTSSGTEKMLVV-SKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKA
| .   |.    .  |. . || .|.  |    .     . .| .... ..||     || ..|    | ||.  |. .  |   . .| .  . .||. 
tilnaltvintedasseplymn.hvqvpwwpdqlap...edarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivre

IRSQRPNAVDSIKQYASIYLCFVYYI
.|. | .||.|  |.  .|. .. |.
mramrfqavqshmqflflyvvlmeyf

subfamily_PTPRB_pd Subfamily PTPRB 196-413 1e-15 52.6 In-house 67-288 (293) alignment
Range on Protein: 196-413
Range on HMM: 67-288/293.0
IVKN----PAQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLM-GTEDEK---NDFFPTTMGAyVYYGAMFVNIRKVEKMDEE
 ||       . . |.| . .   ...   . .| |  .  ..|||  ... . |. .|    |  |   ....|..  . |.|| . |.. . |.... 
rvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep.vlyGdikvtlvaeeeledw

RTRyTIEVLPngFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRS
 .| ....     ...  .. | .| |   ||| . ..  . |  | . ..... .. ..|    | ||.| |..|   .  ....    |  || ..|.
vir.elkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelRe

QRPNAVDSIKQYASIYLCFVYYIKKK
.| . | . |||  |. | . ...||
eRnllvqtekqYifihqcvldllrkk

subfamily_PTPN12_pd Subfamily PTPN12 201-416 2.3e-16 54.5 In-house 65-283 (290) alignment
Range on Protein: 201-416
Range on HMM: 65-283/290.0
AQPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYV-LMGTEDEK---NDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVL
 . ..|.| ...  .. .   . || |     ..|||  .. .| |. .  .  | .|   . ..| ...  . .|.. |.  . ...|.. .  |..| 
eegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkve

PNgfSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKtsSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEP---RIGEIVKAIRSQRPNAV
 .  ..| ... . .| |   ||| .  .  . . .| .. .  |  . ..|    |.||.|  ...  .   |...  |    . ..|  .| ||. .|
aq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalv

DSIKQYASIYLCFVYYIKKKITI
 . .||  .| . . ...|...|
qtkeqyelvykavaelvqkelei

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 202-410 2.7e-18 61.0 In-house 73-279 (288) alignment
Range on Protein: 202-410
Range on HMM: 73-279/288.0
QPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNES---VVIMYVLMGTEDEK-NDFFPTtMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVlp
.   |.| | . . . .   . .| |     ..||.  ...    .| .  |.  ...| ....|.  .  . || . | .........  .|  . .  
agaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlrkllle..

nGFSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTSSGTE--KMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDS
    . . .. | ...|   |||    . .. ...... ||...  .  ...|.  .| ||.| |..| |.   .. .    . ..|. .| ||.. |. 
.kkkteleitqyqylaWpdhgvP....eskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt

IKQYASIYLCFVYYI
 |||  || . .  |
lkqYefiyevllsli

subfamily_CG7180_pd Subfamily CG7180 202-407 3.1e-15 50.6 In-house 68-287 (296) alignment
Range on Protein: 202-407
Range on HMM: 68-287/296.0
QPDSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKN---DFFPTTMgaYVYYGAMFVNIRKVEKMDEERTRyTIEVLPN
. . |.| . |         .. ..||.   .||||  ..| .  . ||  | | ..   ...| ..     || .||.| ..... . ..| |. .  .
eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkir.tfkltkk

----G------FSNSVMMNVYVHTGWEA-SGVPVR---YANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKA
    .        .  .. ..  | ||    ||.    . .  | |  ... |.    .. ..|||..| .|.| .|.. |.   .. . |  . | || 
ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavkt

IRSQRPNAVDSIKQYASIYLCFV
.| .||. |.....|  ||  . 
lrrsRpqLvenveeYkyiYdvll

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 204-408 1.5e-15 52.4 In-house 53-253 (284) alignment
Range on Protein: 204-408
Range on HMM: 53-253/284.0
DSYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVViMYVlMGTEDEKNDFFPTTMgaYVYYGAMFVNIRKVEKMDEeRTRYTIEVLPNGFSN-
  |.| | .     .   . .| |.    ..|||  ..  .   .| . |.|   ...|  .   . .. . |..  ||. .|  .   ||.  .|  . 
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncs.tiv.lltkdkcsqywplki..vikeerfkvkvdsveesee.yvvrdielsedgkekd

SVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASI
   .. .   ||   |||   ..  | |  |  . .   . ....|    |.||.| .. | . .  .....   . ..|. .| ||.. |... ||  |
irkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

YLCFVY
|  .. 
ysalle

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 204-411 5.4e-08 27.3 In-house 46-260 (290) alignment
Range on Protein: 204-411
Range on HMM: 46-260/290.0
DSYVNMSSVIVPHCRYPILMaQMPKRG-------FEEEFWRAAFNE---SVVIMYVLMGTEDEKND-----FFPTTMGAYVYYGAMFVNIRKVEKMDEER
| |.  . |..|.    ||. | |.           |.|| .| .|   .|| .   .  . ....     ..|...|  . .. . |.  . || |.  
ddyiHAnrvtcpnglrlilt.qsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

TRyTIEVLPNGfSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKtSSGTeKMLVVSKNGCGRAGFFLSLGAAFCCLN-DNSEPRIGEIVKAIRS
|| ...|  ..  .   .. .   ||. . |.    ..|.........||  |.|  ..|  ..|  |   . ..  ..  .   ...  . ...||.|.
tR.elvvkfdd.eeeftvtHsllkgWnklnvq....edtktllsliqkvk.askt.pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRPNAVDSIKQYASIYLCFVYYIK
|| .|. | ...| .    | ...
qralaitsalelafvdagivllai

subfamily_PTPRA_pd Subfamily PTPRA 205-409 5.4e-15 50.1 In-house 87-294 (330) alignment
Range on Protein: 205-409
Range on HMM: 87-294/330.0
SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNE---SVVIMYVLMGTEDEKNDFFPTTMGAyVYYGAMFVNIRKVEKMDEERTR-YTIEVLPNGF
 |.| | .   . .   . || ||.   |.|||  ..    ..|..  |   ..||   .  . |. | || . |...... . .   | . .. ||.. 
dyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdat

--SNSVMMNVYVHTGWEASGVPVryanTTRSVVDVMNFVKTSS---GTeKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDS
   .| ... .  |.|   |||.    ... ...... ||.     .   . |    | ||.| |. | | .  .. .    . |.|| .| |||. | .
rekksrlvrqfhftswPdvGvPf....epiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqt

IKQYASIYLCFVYY
 .||  ||     |
deqyefiykvlley

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 205-406 2.2e-14 48.1 In-house 78-275 (315) alignment
Range on Protein: 205-406
Range on HMM: 78-275/315.0
SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGT---EDEKND-FFPTTmgaYVYYGAMFVNIrkveKMDEERTRYTIEVLPNGF
 ||| . .     .   . || |.    ..|||  |.| .  . .| ..   | .| . ..|      | || . |      | .|  |.||.  |   |
dyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtr....kseevnteytvrtlsvvf

SNSVMMNVYV-HTGWEASGVPVRYANTTRSVVDVMNFVKTSSgtEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQY
 . .   | . .| |  .|||    .    .  |. . ..|     ..|  ..| ||.| |..| | .  .. .    . .... .|..| ..|....||
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy

ASIYLCF
  ||  .
qfiydal

subfamily_PTPRK_pd Subfamily PTPRK 205-403 3.1e-14 47.5 In-house 72-270 (314) alignment
Range on Protein: 205-403
Range on HMM: 72-270/314.0
SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNES--VVIMYVLMgTEDE---KNDFFPTTMGAyvyYGAMFVNIRKVEKMDEERTR-YTIEVLPN
 |.| . .   .     ...| |..   ..|||  ..|    ..|   . .|        ..|        || . |.. ..|   |  .| ...| |  
dyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklar

GFSNSVMMNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTssGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQ
| ..  ... . ..|| . .|||      . |  | .  .   .  ...|   .|.||.| |. .      .. ..   . ..||..||...| |.  .|
gqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeq

YASIY
|  ||
ykfiy

0043147 (Phosphotyrosine protein) phosphatases II 205-403 8.4e-09 30.9 In-house 6-154 (172) alignment
Range on Protein: 205-403
Range on HMM: 6-154/172.0
SYVNMSSVIVPHCRYPILMAQMPKRGFEEEFWRAAFNESVVImyVLMGTEDekndffpttmgayvyygamfvnirkvekmdeertrytievLPNGFSNSV
 |.| | . ....   ... | | |   ..|||   .. . .  ... ||                                         | ..   . 
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgith..ivnltel........................................lydpeller

MMNVYVHTGWEASGVPvrYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLndnsepRIGEIVKAIRSQRPNAVDSIKQYASIY
.   | ...|.  |||   ..  ..... .. .   |  ...||  . |.||.|..  .    ..|       . |.|. .|..||.|| .  ||  .|
lgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrfly

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 205-405 5.2e-06 20.5 In-house 60-290 (297) alignment
Range on Protein: 205-405
Range on HMM: 60-290/297.0
SYVNMSSVIVPHCRYPI--LMAQMPKRGFEEEFWRAAFNESV-VIMYVLMGTEDEK---NDFFPTTMGAYVYYGAMFVNIRKveKMDEERTRYTIEVLPN
 |.|   |. |.   ..  ..|| | .   ..||.  ... | ||. |    || .     ..| . .     | . |.     .. .|  |  .  |  
dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvefls..stsdefdrviltelql

GF-SNSVMMNVYVHTGWEASGVP------VRY-A---------NTTRSVVD---VMNFVKT------SSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLND
 . |.| ...   . .|   |||      ||. |             ..|.   .| |..             .||    | ||.|  .   .    |  
iyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrk

NSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLC
.  | .  |.. .|.||.  | ...|.  .|  
kripdvaailsilreqrarlvqtleqfellyda

0049260 (Phosphotyrosine protein) phosphatases II 219-403 7.7e-07 24.4 In-house 9-143 (152) alignment
Range on Protein: 219-403
Range on HMM: 9-143/152.0
YPILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKNDFFPTTMgayvyygamfvnirkvekmdeertrytievlpngfsnsvmmnVYVHTGWEASG
.... .| | .   ..|||   .  . .  .|.  .. . ....  .                                           | |. |. .|
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhg

VPVRYANTTRSVVDVMNFvkTSSGTEKMLVVSKNGCGRAGFFLSLGAAFcclndnSEPRIGEIVKAIRSQRPNAVDSIKQYASIY
||         .  .  .    .  .. ||  . |.||.|..  .              . |.|. .|..||.|| .  |.  .|
vpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 221-403 7.1e-12 40.0 In-house 47-232 (237) alignment
Range on Protein: 221-403
Range on HMM: 47-232/237.0
ILMAQMPKRGFEEEFWRAAFNES--VVIMYV-LM-GTEDEKNDFFPTTMGAyVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEA
 . || |     ..||.  ..|   |..|   |. | |    ...| |      || . | ..| |.. .   |  . .      .  ..  |  | |  
yiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp.aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpd

SGVPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIY
 ||| . |   |   ...|  .  | .   ..    | ||.| || . | .   ...    | . |..|  .||  ...  ||  |.
rgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih

subfamily_PTPRG_pd Subfamily PTPRG 221-415 3.3e-11 37.1 In-house 93-292 (563) alignment
Range on Protein: 221-415
Range on HMM: 93-292/563.0
ILMAQMPKRGFEEEFWRAAFNESVVIMYVLMG---TEDEKND-FFPTtmGAYVYYGAMFVNIRKVEKMDEERTR-YTIEV--LPNGFS--NSVMMNVYVH
 ...| | .   . |||  ... | |. ..      . .| | ..|.     . |||. |.. . |..    .|  .|.   | .. .  .  ..  |  
fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhy

TGWEASGVPVRYANTTRSVVDVMNFVKTSSGteKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
| |   |||   .     |.      |.  |   ..|  ..| ||.| .. | .    .....   . ...| ||.||.. | .. ||  ..  ..  |.
tkWPdhgvPehslpvLifvkkssaankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

KKIT
 | |
sket

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 221-408 5.8e-10 33.2 In-house 93-277 (439) alignment
Range on Protein: 221-408
Range on HMM: 93-277/439.0
ILMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDeKNDFFPTTmgAYVYYGAMFVNIRKVEKMDEERTRyTIEVLPNG--FSNSVMMNVYVHTGWEASG
 . .|.||.   ..|||  ... .| . .|    .    ..|.   | |.|| . | . .  .. .   |  . |. .     .   .  . .. |    
yiatqgpkkettddfwrlviekktvtivmltnlve.sykywpsd..aevcygdiavrvdrnielpnyvir.gfkvfnerdttekertvlqfhyiawpdkn

VPVRyANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVY
|| . |      .  .|  . .  .  ..|    | ||.|  ..|  |.  |. . .  |  ||| .| || . |... ||  || . . 
vpaq.ashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

0051429 (Phosphotyrosine protein) phosphatases II 221-424 1.1e-09 33.9 In-house 24-239 (272) alignment
Range on Protein: 221-424
Range on HMM: 24-239/272.0
ILMAQMPKRGFEEEFWRAaFNESVVIMYVLMGTE---DEKNDFFPT-----------TMGAYVYYGAMFVNIRKVEKMDEERTRYTIEVLPNGFSNSVMM
.. ...| .  ...|||   .. .     |...|    .| |...            ..   . |||..| . ..| ..    |. . .|  . ... ..
lyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

NVYVHTGWEASGVPVRYanttrsVVDVMNFVKTssgTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPR--------IGEIVKAIRSQRPNAVDSIKQ
 ....|.|   |||  .      ........ .    ...||  . |..| |..  |      ....            . |.|. .|.|||.|| .  |
mhlhytdwpdhgvpqea......llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeq

YASIYLCFVYYIKKKITIPEGMQQKF
|. .| . . .... ..... . . .
ylflyeallellrsllsvraeyllaa

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 222-413 3.8e-34 111.8 In-house 121-312 (346) alignment
Range on Protein: 222-413
Range on HMM: 121-312/346.0
LMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTEDEKN---DFFPTTMGAYVYYGAMFVNIRKVEKMdEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASG
 . || .  | |.||   ..| . ..|...  .  ||    .|    | | | | ||.| |. .    .   |||||||.| |.||. .|. |. |    
qlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvs.gdpkeytievlpegnsdsvicqvhhhapwkhlq

VPVRYANTTRSVVDVMNfvKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
 | .     . . . .   .    .  . |||  |||||  |.    |   ||.  || | ||.|.|. ||| .|.|. ||||||   . || .|
qppktlpiikmihqfls..ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiark

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 222-413 1e-17 59.0 In-house 67-267 (270) alignment
Range on Protein: 222-413
Range on HMM: 67-267/270.0
LMAQMPKRGFEEEFWRAAFNESVV--IMYVLM-GTEDEK-NDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTR-YTIEVLPNGFSNSVMmnVYVHTGWEA
. |. |.    ..|||  ..| |   .|   .     .| . ..|.  .  | . ...........  ||  .   ...  .| .. ..   . .. |  
iaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpd

SGVPVRYA--NTTRSVVDVMNFVKTS-SGTEK---MLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYI
 ||| .     .|.... ... |. | . ..|   .||   .| ||.| .. |  |...|. ...  . .|....| .|.. |.  .||. .|   | |.
hgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

KKK
...
err

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 222-414 6.8e-14 46.6 In-house 92-284 (318) alignment
Range on Protein: 222-414
Range on HMM: 92-284/318.0
LMAQMPKRGFEEEFWRAAFNE-SVVIMYVLMGTEDEK---NDFFPTTmGAyVYYGAMFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEAS
. || |     |.|||  ..  | ||. .   .|  |   . ..|   |.   ||.. |....  ....   | ...|  .. ..| ..  | .| |  .
iaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.gs.rsygklvvelkeevelsdyvlr.efkvtrteeeesrqvrqyhytsWpde

GVPVRYANTTRSVVDVmNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKI
|||   |.    | .| . ....||.. ..|    | ||.| |. . .    .....   . ..|| .|.||.  |   .||  ||   . ...   
gvpesgaslldlvrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 222-416 5e-10 33.6 In-house 93-287 (301) alignment
Range on Protein: 222-416
Range on HMM: 93-287/301.0
LMAQMPKRGFEEEFWRAAFNES---VVIMYVLMG-TEDEKNDFFPTTMGAYVYYGAMFVNIRKVEKM-DEERTRYTIEVLPN--GFSNSVMMnVYVHTGW
. .| | .   |.||          .|..   .  .|.  ....|....  .  |   ..|.. |.. ... .. |.||      |.   ..  | .. |
iatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvt.hyqysew

EASGVPVRYANTtrsvVDVMNFVKTSsgTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKKI
 . |||  .|..     |.|..|| |   . ..|   .| ||.  |..       .. . .  . | .| .| .| |.|   .|   . |  || . |. 
tdrgvPkshael....fdlmelvkks..ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikey

TI
 .
gf

subfamily_PTPN6_pd Subfamily PTPN6 222-415 7.5e-10 33.3 In-house 101-302 (306) alignment
Range on Protein: 222-415
Range on HMM: 101-302/306.0
LMAQMPKRGFEEEFWRAAFNES-VVIMYVLMGTEDEKN---DFFPTTMGAYVyYGAMFVNIRKVEKMDEERTRyTIEVLP-NGFSNSVMMNVYVHTGWEA
. .|   .   ..||| ...|.  ||. . . .|  |.    ..|..      || . |.  . .....   | .. |   .  ...  .  | .. |  
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilR.elsvskkkkkkeerevfqyhfksWPd

SGVPVRYANTTRSVVDVMNFVKTSS--GTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDN---SEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIK
 |||         . || .  ....   .  ..|   .| || | |. . .    .. .    .  | ..|| .|.||   |   .||  .|    .||.
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

KKIT
.| .
tkkk

subfamily_egg_pd Subfamily egg 222-417 2.7e-07 24.5 In-house 86-277 (307) alignment
Range on Protein: 222-417
Range on HMM: 86-277/307.0
LMAQMPKRGFEEEFWRAAFNESVVIMYVLMGTED-EK-NDFFPTTMGAYVYY--GAMFVNIRKVEKMDEERTRYTIEVL--PNgfsnsvMMNVYVHtGWE
..|| | .   ..|||  |.| |  . .|  . . |. . ..| .    . .  |.. ..  ||..  .   | |   |  ..        . ..   |.
ilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerfle.hwq

ASgvpVRYANTTRSVVDVMNFVKTSSgtEKMLVVSKNGCGRAGFFLSLGAAFCCLNDN--SEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
     |....   | . |.  ..  |  . ..| ...|. .|. ....  |.. |         . . |. .| .|. .|.|. .|  .|   .....  
gd...vnnssdvysplrvlrklrnls..kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv

ITIP
|   
igsa

subfamily_PTPRD_pd Subfamily PTPRD 224-413 2.5e-15 51.1 In-house 96-284 (564) alignment
Range on Protein: 224-413
Range on HMM: 96-284/564.0
AQMPKRGFEEEFWRAAFNESVVIM---YVLMGTEDEK-NDFFPTTmGaYVYYGAMFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGV
.| |.    |.|||  ... . .      |   . .| ....|.. |    || . |.. . |.. .   | |...  .  |.| . . . .| |  .||
tqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeir.tfklkkkkssesreVrqFhFtsWPdhgv

PVRYanttRSVVDVMNFVKTSS--GTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
|       .|..|... |....  ... ..|   .| || | |. . |    ....    | ..|||.|.||.  |.. .||. |.   . .... 
pesa....tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 225-413 2.1e-11 38.5 In-house 79-271 (274) alignment
Range on Protein: 225-413
Range on HMM: 79-271/274.0
QMPKRGFEEEFWRAAFNESVVIMYVLMGT-EDEK---NDFFPTTMGAYVY--YGAMFVNIRKVEKMDEertrYTIEVLP--NGFSnSVMMNVYVHTGWEA
| |     ..|||  ..|.| .. .|    | ..   . .||.. .. .   || . ....|. . ..    |... |   .  . .  .  | .| |  
qGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekivernd....ysvrklvlkyler.ersvkhywytdWPd

SGVPVRYANTTRSVVDVMNFVKTSSGT-EKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYIKKK
  .| .  .  . | .| .  ....     ..|    | ||.| |..   |   |....   . .||  .| .|   |.. .||  |.  .. | |. 
hksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 225-415 1.5e-06 21.9 In-house 97-293 (302) alignment
Range on Protein: 225-415
Range on HMM: 97-293/302.0
QMPKRGFEEEFWRAAFNESVVIMYVLMG---TEDEK-NDFFPTTMGAYVYYGAMFVNIRKVEKMDE------ERTRYTIEVLPNGFSNSVM--MNVYVHT
 .||.   | .|    . .| |.  | .    |..|  ... . .|  . .|   |.  .|..  |      . . ||.|.  .   . |   ... ...
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWEASGVPvryaNTTRSVVDVMNFVKTSsgTEKMLVVSKNGCGRAGFFLSL--GAAFCCLNDNSEprIGEIVKAIRSQRPNAVDSIKQYASIYLCFVYYI
.|   | |    . . . .|...| ..    ...||   .| ||.| ....  |  .|  .. ..  . .||. .|. |  || . .|   . ||    .
awpdhGap....keaytaldilkfcesy..kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtd..llsivlpvrqcryGavqdeqqliylllcvtkgl

KKKIT
 .|..
mekag

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 233-405 1.8e-10 35.4 In-house 66-236 (239) alignment
Range on Protein: 233-405
Range on HMM: 66-236/239.0
EEFWRAAFNESVVIMYVLMGT-EDEKNDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVPvRYANTTRSVV
 .|||  ..|  ... .| |  |  |.  .     .   |  . | .|| | . .   | |. .   | ..   .  |  | |   ||| .|| .   . 
gdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir.tfvmsqvgqteeryvyqyhftvwpdkgvp.qyatavlglr

DvmNFVKTS-SGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLC
   .  | |  |.   ..    | ||.| || . | .   . .    | . ||||| .||  |.. .||  |.|.
r..kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 233-405 1.8e-10 35.4 In-house 65-235 (239) alignment
Range on Protein: 233-405
Range on HMM: 65-235/239.0
EEFWRAAFNESVVIMYVLMGT-EDEKNDFFPTTMGAYVYYGAMFVNIRKVEKMDEERTRyTIEVLPNGFSNSVMMNVYVHTGWEASGVPvRYANTTRSVV
 .|||  ..|  ... .| |  |  |.  .     .   |  . | .|| | . .   | |. .   | ..   .  |  | |   ||| .|| .   . 
gdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir.tfvmsqvgqteeryvyqyhftvwpdkgvp.qyatavlglr

DvmNFVKTS-SGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASIYLC
   .  | |  |.   ..    | ||.| || . | .   . .    | . ||||| .||  |.. .||  |.|.
r..kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

0048179 (Phosphotyrosine protein) phosphatases II 268-404 1.7e-07 26.6 In-house 10-139 (144) alignment
Range on Protein: 268-404
Range on HMM: 10-139/144.0
YVYYGAMFvNIRKVEKMDEERTRYTIEVLPNGFSNSVMMN--VYVHTGWEASGVPvryaNTTRSVVDVMNFVKTS-SGTEKMLVVSKNGCGRAGFFLslg
..|.| .    ...| . .   .. | . ..   ...  .   |.|..|.  |||    . .  . ....|...  .  ...||  . |.||.|..    
glylgslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvp....dllellleflefieealeeggpvlVHCsaGvgRtgtlv...

AAFCCLNDNsePRIGEIVKAIRSQRPNAVDSIKQYASIYL
||. ..  .    . |... .||.||.|| .  |.  ...
aaylmkklg..lsleealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 269-408 4.9e-08 28.3 In-house 11-141 (145) alignment
Range on Protein: 269-408
Range on HMM: 11-141/145.0
VYYGAMFvNIRKVEKMDEERTRYTIEVLPNGFSNSVMMNVYVHTGWEASGVPvryaNTTRSVVDVMNFVKTS--SGtEKMLVVSKNGCGRAGFFLslgAA
.|.| .  . ...| . .   .. . . ..    . .   |....|.  |||    . .. . ....|...   .| ...||  . |.||.|..    ||
lylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvp....dllellleflefieealkeg.gpvlVHCsaGvgRtgtlv...aa

FCCLNDNsePRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVY
...|  .    . |... .|||||.|| .  |.  .|..  .
ylmlllg..vsleealelvrsqrpgavpnpgqlrflyefele

0036282 (Phosphotyrosine protein) phosphatases II 302-403 2.4e-08 29.3 In-house 65-163 (174) alignment
Range on Protein: 302-403
Range on HMM: 65-163/174.0
NSVMMNVYVHTGWEASGVPVRYAntTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNdNSEPRIGEIVKAIRSQRPNAVDSIKQYAS
 . .   |....|.  |||       ...|. .. .  ...  ..||  . |.||.|..  .    ..|  .|   . ..|...|.|||..| .  ||  
lerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IY
.|
ly

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 303-403 1.3e-06 22.0 In-house 88-187 (440) alignment
Range on Protein: 303-403
Range on HMM: 88-187/440.0
SVMMNVYVHTGWEASGVPvRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVDSIKQYASI
|  .. | . ||   ||| ..|     ... .|  .  .|   .|| .  |.||.|  ... . .   . . .  |  .....|..||. |.. .||| .
srtlkqyhyqgwpdkgvp.kfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

Y
.
h

PTPc_DSPc_SM00012 306-406 4.4e-17 57.6 In-house 2-103 (105) alignment
Range on Protein: 306-406
Range on HMM: 2-103/105.0
MNVYVHTGWEASGVPVRYANTTRSVVDVMNFVKTSSGTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDN-SEPRIGEIVKAIRSQRPNAVDSIKQYASIYL
...| .|||   ||| .  . .. . .|... . |. .. ..|....|.||.| |  |  . . |... .|. | .|||..|.|||..|..  ||  .| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CF
. 
al