Gene C24F3.2 in Caenorhabditis elegans

Synonym: CELE_C24F3.2, C24F3.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP023_AA protein Get Run
CeleP023_AA_0-147 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 1-153 2.5e-53 174.7 In-house 2-150 (155) alignment
Range on Protein: 1-153
Range on HMM: 2-150/155.0
MWKITENLYLAQLPMIVGPTSKQEFsknDIKRVLTLTTEPI-SEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRS
...|...|||..|.... .....|.   .|..||....|.. ..|.|.| |..||...||.|.|.||..  |..|| .|.|..|.|..| ||| |.||||
vsrilpglylggleavqeeellkel...kithvlsvikeelpehklkkgkvstkfiqilDepeediLsh..ldeavdFieealeeegavlvHCqagvSRS

VSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERSGMSFSADQ
|.|..||||.|.....|||||........| ||.|||.|||..|..|..   ..
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsn

subfamily_DSP15_pd Subfamily DSP15 1-146 8.1e-25 81.7 In-house 2-139 (151) alignment
Range on Protein: 1-146
Range on HMM: 2-139/151.0
MWKITENLYLAQlpmIVGPTSKQEFSKNDIKRVLTLTTepiSEKQKIGGVDYKFLHLLDMPDEPIldNAILETAVLYINEGVEKEENVGVHCLAAVSRSV
. |. ..|||..   .     ..  ....|  .|..     ..|. .  ..||.... | |.  .  . ... .| .| .   ||||| ||||| |||||
iskvlpglylgn...frdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsakl..skffkesvefihkcRlkeenvlvhClaGvsRsv

SICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERSG
 ...||||   .   ..||..|.  | .  ||.||  ||| .|.. 
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk

0046846 (Phosphotyrosine protein) phosphatases II 1-144 8.5e-22 73.2 In-house 12-170 (176) alignment
Range on Protein: 1-144
Range on HMM: 12-170/176.0
MWKITENLYLAQLPMIV-------GPTSKQEFSKNDIKRVLTLTTE------------PISEKQKIggvdykFLHLLDMPDEPILDNAILETAVLYINEG
.. |..||.|  .| .         ..  ... ...|. |..||.|            |. || .|        . |..||  . | ..|.... .|.| 
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......qylhlpwpDhgvpdlelllellefirea

VEKEENVGVHCLAAVSRSVSICAAYLMYK-NQWPVEKALKMIESVRK-TIGPNAGFLAQLKIWER
... ..| ||| | ..|.  ..||||... ....||.||... ..|   . .. ... .|. .|.
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel

0044763 (Phosphotyrosine protein) phosphatases II 2-147 5e-28 93.3 In-house 24-171 (178) alignment
Range on Protein: 2-147
Range on HMM: 24-171/178.0
WKITENLYLAQLPMivgPTSKQEFSKNDIKRVLTLTTEPISEKQK-------IGGVDYKFLHLLDMPDEPilDNAILETAVLYINEGV-EKEENVGVHCL
..|...|||..||.   .  .. . ...|. ...||.|    ..|         |. |..... |... .    .... .| .|.| . ||...| ||| 
seilpglylgslpp...addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd..llehflefvefieealdekggpvlVHCs

AAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKtIGPNAGFLAQLKIWERSGM
| |.|| ...|||||.|.....|.|.... ..|  | || |.| ||. .|.  .
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll

0048179 (Phosphotyrosine protein) phosphatases II 2-144 4.2e-26 86.8 In-house 5-142 (144) alignment
Range on Protein: 2-144
Range on HMM: 5-142/144.0
WKITENLYLAQLPMIVGptsKQEFSKNDIKRVLTLTTEPISEKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVS
..|...|||  ||. .     ... |..|. |..||.|   |  .  |. | .| . |..  ..|  ..|.... .|.| .|....| ||| | |.|. .
seilpglylgslptald...lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdll..ellleflefieealeeggpvlVHCsaGvgRtgt

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..|||||.|.....|.||... | |  . || |.| .|. .|.
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

0048076 (Phosphotyrosine protein) phosphatases II 2-144 1.8e-24 81.4 In-house 5-140 (145) alignment
Range on Protein: 2-144
Range on HMM: 5-140/145.0
WKITENLYLAQLPMIVGptsKQEFSKNDIKRVLTLTTEPisEKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVS
..|...|||  ||. .     ... ...|..||.||.|.  |  .  |. | .| . |..  ..|  ..|.... .|.| ......| ||| | |.|. .
seilpglylgslptald...lellkdlgittvlnltsel..ellerlgiqylylpwpDhgvpdll..ellleflefieealkeggpvlVHCsaGvgRtgt

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..|||||.......|.||... | |  . || |.| .|. .|.
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel

subfamily_DSP14_pd Subfamily DSP14 2-145 2.5e-22 73.5 In-house 8-143 (157) alignment
Range on Protein: 2-145
Range on HMM: 8-143/157.0
WKITENLYLAqlpmIVGPTSKQEFSKNDIKRVLTLTTEPISekQKIGGVDYKFLHLLDMPDEPILDnaILETAVLYINEGVEKEENVGVHCLAAVSRSVS
 .||..|.|.     |. .||....|. |  .. .|.|  .  .|. ....  . . |.|.. . .   ..... .|.|  .|. .. ||| | |||| |
sqitpsLfls....gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklak..hfdevadkieevkkkggktlvhCvaGvSRSAs

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
.| ||||  ..   ..| |...|.|  | || ||  ||  .|. 
lclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk

0041856 (Phosphotyrosine protein) phosphatases II 2-145 4e-22 74.1 In-house 20-171 (182) alignment
Range on Protein: 2-145
Range on HMM: 20-171/182.0
WKITENLYLAQLPMIV-----------GPTSKQEFSKNDIKRVLTLTtEPIS--EKQKIGGVDYKFLHLLDMPDEPildnaiLETAVLYINEGVEKEENV
..|..||||  ||               .   . . ...|. ...|| |.    |. .  |. |..|   |..  .      |.... .|.|  |....|
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd......ldelldfieevleeggpv

GVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRK--TIGPNAGFLAQLKIWERS
 ||| | |.|. ...|||||.|.....|.|.|.. | |    | || .|. ||...|. 
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell

0036282 (Phosphotyrosine protein) phosphatases II 2-143 1.5e-19 65.8 In-house 13-166 (174) alignment
Range on Protein: 2-143
Range on HMM: 13-166/174.0
WKITENLYLAQLPMIvgptSKQEFSKNDIKRVLTLTTEPISEKQKI----------GGVDYKFLHLLDMPDEPILDNAILETAVLYINEGVEK--EENVG
. ||..|.. | |.       ... ...|. |..|..|   .. |.                 .. | .||    | .||...| ...| ...  .  | 
syitprliagqgpla....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCLAAVSRSVSICAAYLMYKNQW-PVEKALKMIESVR---KTIGPNAGFLAQLKIWE
||| | |.|.  ..|||||..... ....||... ..|     . .. ... .|  .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe

0037934 (Phosphotyrosine protein) phosphatases II 2-143 1.4e-18 62.8 In-house 40-238 (243) alignment
Range on Protein: 2-143
Range on HMM: 40-238/243.0
WKITENLYLAQLPMIV-----GPTSKQEFSKNDIKRVLTLTTEP------------------------------------------IS-EKQKIGGVDYK
 ..|..|.. |.|.         .  . . ...|. ...||..                                           .. ....  .. | 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

FLHLLD--MPDEPILDNAILETAVLYINE-----GVEKEENVGVHCLAAVSRSVSICAAYLMYKN-QWPVEKALKMIESVRKT-IGPNAGFLAQLKIWE
.|   |  .||.|    ..|. .  .|.|        ... | ||| | |.|.  ..|||||... ....|.|.|.. . |   . .. ... .|  ..
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

0051082 (Phosphotyrosine protein) phosphatases II 2-141 1.9e-17 58.7 In-house 9-148 (151) alignment
Range on Protein: 2-141
Range on HMM: 9-148/151.0
WKITENLYLAQLPmivGPTSKQEFSKNDIKRVLTLTTEP----ISEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEK-EENVGVHCLAAV
. .|..||. . |    .   ... ...|| ...|..|.      |  .  |.... ...||.|| .. ..  ..... ....  .| . .| ||| | .
syvtgglyrsggp...ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglpls..fdavleflellldkkngpvlvHCsaGk

SRSVSICAAYLMYkNQWPVEKALKMIESVRK-TIGPNAGFLAQLKI
.|.  ..|.|||.  ....|.||... . |   . || .|| ||. 
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_DSP19_pd Subfamily DSP19 3-144 1e-25 84.8 In-house 14-148 (152) alignment
Range on Protein: 3-144
Range on HMM: 14-148/152.0
KITENLYLAQLPmivGPTSKQEFSKNDIKRVLTLTTEPISEkqKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSI
.....|||.      . ..|.......|  .| ..|.          . |. ...|| |.. .|.   |..|. .|.|. .|.  | ||| | ||||.|.
eveprlylgsqd...vaadkeilkekkitHilnvatgvpnv..fpkdftylsieilDlpetdllsy..lkealdFieearskdgavlvHCnAGvSRsasv

CAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
  |||| |..  .|.||... ..|..| ||.||. ||| .| 
viaylmkkeelsleealelvrearpcikPneGFikqLkeyea

PTPc_motif_SM00404 3-144 2.4e-24 80.8 In-house 4-139 (140) alignment
Range on Protein: 3-144
Range on HMM: 4-139/140.0
KITENLYLAQLPMIVgptSKQEFSKNDIKRVLTLTTE-PISekQKIGGVDYKFLHLLDMPDEPILDnaILETAVLYINEGVEKEENVGVHCLAAVSRSVS
.|...|||.... ..   ...  .|..|. |. .|.| ...  ..  |. .. . | |   .....   |. .. .|..  .|...| ||| | ||||..
rilphlylgskskaq...npallkklgithvinvteevslt..kensgfqilqiplddnekdklsk..yldkvldfienaekkggkvlVHCqaGvSRSat

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
...||||...|. ...|...... |..| ||..|..||  .|.
liiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_DSP8_pd Subfamily DSP8 3-145 6.2e-17 55.6 In-house 17-153 (159) alignment
Range on Protein: 3-145
Range on HMM: 17-153/159.0
KITENLYLAQLpmiVGPTSKQEFSKNDIKRVLTLTTEPIsEKQKIGGVDYKFLHLLDMPDEPILDnaILETAVLYINEGVEKEENVGVHCLAAVSRSVSI
.|..||||      . . |.. .||..|  || . .. . .....  . .  . . |  || .|.  .....| .|.  .... .| ||.||  ||| ..
rilknlylGsq...kdvlseellsklgisyvlnasnscp.kleelkeskflrvPvkDkydekllp..wfdksvefidkaksengrvlvhvlaGisrsatv

CAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
  ||.| . .  ...| . . . |.|| ||  || ||  .|..
aiayimktlemsldeayrfvkekrptispnlnflgqLleyeke

0042113 (Phosphotyrosine protein) phosphatases II 3-143 1.7e-16 55.8 In-house 49-239 (245) alignment
Range on Protein: 3-143
Range on HMM: 49-239/245.0
KITENLYLAQLPMIVgptSKQ----EFSKNDIKRVLTLTTEPISEK-----------------------------------------QKIGGVDYKFLHL
.||......| |.     . .     . ...|. ...||.|   ..                                         ..        .| 
ritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

LDMPDEPILD-NAILETAVLYINEGVE--KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWE
|..|| .. |  ..|. .. .... ..  ... | ||| | |.|.  ..|||||     .   ...|.|.|.. | |  . .. ... .|  ..
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

subfamily_PTPMT1_pd Subfamily PTPMT1 3-137 7.3e-16 53.1 In-house 22-159 (171) alignment
Range on Protein: 3-137
Range on HMM: 22-159/171.0
KITENLYLAQLPmiVGPTSKQEFSKNDIKRVLTLTTE-------PISEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAA
.| ....| .||  .  . |. ..|...|.|..|. |         .|. |  ||..  |   |. ..| |..  || .| .|..  .| . | ||| | 
riDdtvilGalP..frslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdlek..lekgvefiekvaskgkrvYvHCkaG

VSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLA
 .|| .. |.|||.|...  |.|||.... ||.|  .   . 
rgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwk

subfamily_DSP6_pd Subfamily DSP6 4-145 1.7e-22 73.6 In-house 17-153 (158) alignment
Range on Protein: 4-145
Range on HMM: 17-153/158.0
ITENLYLAQLPMivgPTSKQEFSKNDIKRVLTLTTEPISEKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSIC
|...||| .       .  . ..| .||.|| .|..  .  .. | . |. . . |   . .   . .  |. .|.|. .|...| ||||| .|||| ..
ilpllylGsakd...asnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnla..kffPeaiefidearskkskvlvhClaGisrsvtvt

AAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
 |||| |..  ...| ..... .  | ||  |. ||. .|||
laylmkklalslndaydlvkkrksnisPnfnfmgqlldfers

subfamily_DSP1_pd Subfamily DSP1 4-145 6.5e-22 72.3 In-house 21-155 (163) alignment
Range on Protein: 4-145
Range on HMM: 21-155/163.0
ITENLYLAQLpmiVGPTSKQEFSKNDIKRVLTLTTEpISEKQKIgGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSIC
|.. |||         . ..  ....|  .| ...| ...  .     || |.| | |.. |   ...|... .|.|  .|.  | .|| | .||| ..|
ildfLylGse...tvasnleiLkslgitailnvske.ldnvfed.lfeYkklkleDspkadis..lvfeeviefidevkkknGkvlihCqaGisRsstlc

AAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
 |||| .... .|.| ... ..|. | |||||  ||. .|..
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk

0051429 (Phosphotyrosine protein) phosphatases II 6-144 2.4e-16 55.7 In-house 21-222 (272) alignment
Range on Protein: 6-144
Range on HMM: 21-222/272.0
EN-LYLAQLPMIVGPTSKQEFSKNDIKRVLTLTTEPISEKQK----IGGVDYKFLHLLDMPDEPILDNA-------------------------------
.. ||... |. . . . . . ...|| ...|..|   ...|    . |..| .|..||. ...|| .|                               
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

--------------ILETAVLYIN----EgvekEENVGVHCLAAVSRSVSICAAYLMYkNQWP--------------VEKALKMIESVRKTIGPNAGFLA
              . . |.| .     .    ...| ||| | ..|.  ..|..|..  ...              .|.|.... ..|  .... ....
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLKIWER
.|  ...
flyeall

subfamily_DSP23_pd Subfamily DSP23 10-124 4.5e-08 27.9 In-house 12-123 (148) alignment
Range on Protein: 10-124
Range on HMM: 12-123/148.0
LAQLPMIVGPTSKQEFSKNDIKRVLTLTTEPISEKQKIGGVDYKFLHLLDMpDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMY
|| | .   |   . .  . .. ...||.|   . . . .. .. | . |.   | |..  ..  |  ..|  ||.| |.||||    |. .. | ||. 
laalalprlpdqyrylldlgvrylvslteegrphveatpnltlvrlriddy.hppaleq..vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvk

KNQWPVEKALKMIES
...    .|.  .  
erklaaaeaiaevrr

subfamily_DSP10_pd Subfamily DSP10 21-144 3.2e-21 69.8 In-house 31-151 (159) alignment
Range on Protein: 21-144
Range on HMM: 31-151/159.0
SKQEFSKNDIKRVLTLTTEPISEKQKiGGVDYKFLHLLDMPDEPIldNAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALK
... . . .|. || .||.   | ..  .. || . . |   . .  .   | |. .|.|  .|...| ||| | .|||...  ||||.. .  ...| |
dldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnl..kqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndayk

MIESVRKTIGPNAGFLAQLKIWER
.... | .| || .|. ||. .|.
fvkekrpiisPnLnfmGqLlefek

DSPc Dual specificity phosphatase, catalytic domain 22-144 4.8e-23 76.5 Pfam-A 11-132 (133) alignment
Range on Protein: 22-144
Range on HMM: 11-132/133.0
KQEFSKNDIKRVLTLTTEPIS-EKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALK
..  .|..|. |. .|.|     ..| .  .|  . . |. .. |   . || || .|..  .|...| ||| | .||| ....||||.........|..
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkis..keleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

MIESVRKTIGPNAGFLAQLKIWER
.... |..| ||||||.||  .||
fvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 22-144 4.8e-23 76.5 In-house 11-132 (133) alignment
Range on Protein: 22-144
Range on HMM: 11-132/133.0
KQEFSKNDIKRVLTLTTEPIS-EKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALK
..  .|..|. |. .|.|     ..| .  .|  . . |. .. |   . || || .|..  .|...| ||| | .||| ....||||.........|..
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkis..keleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

MIESVRKTIGPNAGFLAQLKIWER
.... |..| ||||||.||  .||
fvkerrskispnagflrqLleyer

0043147 (Phosphotyrosine protein) phosphatases II 22-145 2.2e-20 68.5 In-house 37-159 (172) alignment
Range on Protein: 22-145
Range on HMM: 37-159/172.0
KQEFSKNDIKRVLTLTTE-PISEKQKIGGVDYKFLHLLDMPDEpilDNAILETAVLYINE--GVEKEENVGVHCLAAVSRSVSICAAYLMYkNQWPVEKA
 . . ...|. ...||..  . |. .  |. | .|   |..     . ..|. .. .|.|   ..... | ||| | |.|.. ..|||||.  ....|.|
wrmlkelgithivnltellydpellerlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleea

LKMIESVRKTIGPNAGFLAQLKIWERS
.... . |  . .| ... .|. .|. 
valvrekRpgavqnpsqyrflyyfekl

0049260 (Phosphotyrosine protein) phosphatases II 22-143 1e-18 63.0 In-house 26-146 (152) alignment
Range on Protein: 22-143
Range on HMM: 26-146/152.0
KQEFSKNDIKRVLTLTTEPIseKQKIGGVDYKFLHLLDMPDEPILDNAILETAVLYINE--GVEKEENVGVHCLAAVSRSVSICAAYLMYkNQWPVEKAL
.. . ...|. ...||..    . |..   |   . | .|| .  |...|   .| . |    .|...| ||| | |.|.  ..|||||. .....|.|.
wrmlkelgittivmltelle..lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeav

KMIESVRKTIGPNAGFLAQLKIWE
... . |. . || |.| .|. .|
alvrekRpgavpnpgqlrflyefe

subfamily_Slingshot_pd Subfamily Slingshot 22-143 3.9e-18 59.4 In-house 37-154 (169) alignment
Range on Protein: 22-143
Range on HMM: 37-154/169.0
KQEFSKNDIKRVLTLTTEpIsEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKM
 .|...|... .| .| | | ..   . ..|. ... | ... .|..   ...  .|..  .|. .| |||   |||| |.  || | . .. .|.||. 
leelkengveyilnvtke.i.dnffpekfeylnirvydeeetdllky..wnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealey

IESVRKTIGPNAGFLAQLKIWE
... |. | ||.||| ||...|
vkerrsvikPnkgflkqleeye

0045098 (Phosphotyrosine protein) phosphatases II 22-145 2e-17 59.0 In-house 81-270 (278) alignment
Range on Protein: 22-145
Range on HMM: 81-270/278.0
KQEFSKNDIKRVLTLTTE---------------------------------------------PISEKQKIGGVDYKFLHLLDMPDEPILDNA---ILET
 . . ...|. ...||..                                               .|.. .     . ||.| .||  . ..     .  
wrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfle

AVLYINEGVE--------------KEENVGVHCLAAVSRSVSICAAYLMYKN---QWPVEKALKMIESVRKT-IGPNAGFLAQLKIWERS
.. .|.| ..              ... | ||| | |.|.  ..|||||...   .. ...|.|.. | |   . .| ... .|  ... 
llefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_MKPLT_pd Subfamily MKPLT 22-144 5.1e-15 49.4 In-house 40-158 (164) alignment
Range on Protein: 22-144
Range on HMM: 40-158/164.0
KQEFSKNDIKRVLTLTTEPISEKQKigGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKM
..   . .|. .. ...|  .   |   |.|  ... | .|| .   . || |  .. . ..    | |||   .||| |.  |.|.  ..| ...| . 
ekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqls..sfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayey

IESVRKTIGPNAGFLAQLKIWER
.   |  . || ||| ||  .|.
lkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 22-144 5.1e-15 49.4 In-house 40-158 (164) alignment
Range on Protein: 22-144
Range on HMM: 40-158/164.0
KQEFSKNDIKRVLTLTTEPISEKQKigGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKM
..   . .|. .. ...|  .   |   |.|  ... | .|| .   . || |  .. . ..    | |||   .||| |.  |.|.  ..| ...| . 
ekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqls..sfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayey

IESVRKTIGPNAGFLAQLKIWER
.   |  . || ||| ||  .|.
lkerrsivapnrGflkqlakfee

0040439 (Phosphotyrosine protein) phosphatases II 23-143 1.6e-16 56.2 In-house 72-242 (249) alignment
Range on Protein: 23-143
Range on HMM: 72-242/249.0
QEFSKNDIKRVLTLTTEPISEK-----------------------------------------QKIGGVDYKFLHLLDMPDEPIL-DNAILETAVLYINE
. . ...|. ...||..   ..                                         ..   . .. .. .|.||  .  . ..|   . ....
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

GVE---KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWE
 .|   |.. | ||| | |.|.  ..|||||     .......| |.|.. | |  . .| ... .|  ..
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

0045450 (Phosphotyrosine protein) phosphatases II 23-143 2.1e-15 52.7 In-house 125-300 (307) alignment
Range on Protein: 23-143
Range on HMM: 125-300/307.0
QEFSKNDIKRVLTLTTEP---------------------------ISEKQkIGGVDYKFLHLLDM-----------------PDEPILDN-AILETAVLY
. . ..... ...||..                            .||..  .|. .  |.. |.                 ||  . .. ..|   . .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

INEGVE---KEENVGVHCLAAVSRSVSICAAYLMYKNQ--------WPVEKALKMIESVRKTIGPNAGFLAQLKIWE
... .|   |.. | ||| | |.|. ...|||||...         .....|.|.. . |  . .| ... .|  ..
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

0039614 (Phosphotyrosine protein) phosphatases II 23-144 1.2e-14 50.0 In-house 119-286 (297) alignment
Range on Protein: 23-144
Range on HMM: 119-286/297.0
QEFSKNDIKRVLTLTTEP------------------------ISEKQkigGVD----------------YKFLHLLDMPDEPIL-DNAILETAVLYINEG
. . ..... ...||..                         .....     .                .. .. ...||  .  . ..|  .. ...| 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrea

VE---KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..   |.. | ||| | |.|. ...|||||     .. .. |..|.|.. . |  . .. ... .|  ...
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

0040438 (Phosphotyrosine protein) phosphatases II 23-145 1.6e-14 49.3 In-house 104-274 (317) alignment
Range on Protein: 23-145
Range on HMM: 104-274/317.0
QEFSKNDIKRVLTLTTEP--------------------------ISEKQkIGGVDYKFLHLLDM----------------PDEPIL-DNAILETAVLYIN
. . ..... ...||..                           .||..  .|. .  |.. |.                ||  .  .  .|   . ...
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EGVEK-EENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
|  |. .. | ||| | |.|. ...|||||     ..... ||.|.|.. . |  . .. ... .|  ... 
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle

PTEN_1 24-140 1.4e-18 62.4 In-house 62-185 (196) alignment
Range on Protein: 24-140
Range on HMM: 62-185/196.0
EFSKNDIKRVLTLTTEPIS-----EKQKIGGVDYKFLHlLDMPDEPILDNAILETAVLYINEGVEK---EENVGVHCLAAVSRSVSICAAYLMYKNQWPV
.. ...|  |..|. |.       ....    ....|| ....| .  . . |  ..  . | . .   ...| ||| | ..||. ..|||||||... .
nlkedgitlvvnlseeeelsgrsydleeffksgveylh.fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgklta

EKALKMIESVRKTIGPNAGFLAQLK
..||... . |  ..|| ... .|.
deAlelvrekRppgapnspsqerll

0046845 (Phosphotyrosine protein) phosphatases II 25-127 5.4e-10 34.6 In-house 144-254 (284) alignment
Range on Protein: 25-127
Range on HMM: 144-254/284.0
FSKNDIKRVLTLTTEPISEKQkiggVDYKFLHLLDMPDEPIL-DNAILETAVLYINEGVEK---EENVGVHCLAAVSRSVSICAAYLMYKN--------Q
  .. ..|.|.|| . ....     .  . .| .. ||  .  . ..| . . ...|  |.   .. . ||| | |.|.  ..|..|...          
vkddytvrtleltnlgytges....rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllg

WPVEKALKMIESVRK
..|..|.|.. . | 
vdvleavkrlreqRp

0043336 (Phosphotyrosine protein) phosphatases II 27-142 1.2e-11 40.1 In-house 110-272 (278) alignment
Range on Protein: 27-142
Range on HMM: 110-272/278.0
KNDIK---------------------------------------------RVLTLTTEPISEKqkiggVDYKFLHLLDMPDEPIL-DNAILETAVLYINE
.....                                             |.|..|    .|.          .| |..||  .  . ..|   . ...|
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges.....rtvthyhylgwpdhgvpeslsllldflkavre

GVE-KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIW
 .| ... | ||| | |.|.  ..|.||.     .   ...|.|.|.. . |  . ..  .. .|  .
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

0038934 (Phosphotyrosine protein) phosphatases II 29-142 2e-15 52.4 In-house 56-172 (194) alignment
Range on Protein: 29-142
Range on HMM: 56-172/194.0
DIKRVLTLT-TEPISEKQKIGGVDYKFLHLLDMPDEPILDNAILETAVLYINEGVEK--EENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESV
..  |..|| ||.  ..... ......|.|  . | .. ...|| . .  ..| ...  .. |.||| | ..|.  ..||||.|......|.|.......
klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrek

RKTIGPNAGFLAQLKIW
|. . || ..| .|  .
Rpgaipnqdyleallkr

0047943 (Phosphotyrosine protein) phosphatases II 29-139 4.2e-11 38.3 In-house 150-264 (273) alignment
Range on Protein: 29-139
Range on HMM: 150-264/273.0
DIKRVLTLTTEPISEKqkiggVDYKFLHLLDMPDEPIL-DNAILETAVLYINEGVE---KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKAL
 ..|.|.||    .|.       .. .| .. ||  .  . ..| . . ....  |   ... | ||| | |.|. ...|..|.     ..... |..|.
ytvrtleltnlgtges.....rtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleav

KMIESVRKTIGPNAGFLAQL
|.. | |  . ..  .. .|
kllrsqRpgmvqtpeqyrfl

0036941 (Phosphotyrosine protein) phosphatases II 30-143 1.9e-11 39.3 In-house 153-273 (297) alignment
Range on Protein: 30-143
Range on HMM: 153-273/297.0
IKRVLTLTTEPISEKQKIGGvdykfLHLLDMPDEPILD-NAILETAVLYINEGVE---KEENVGVHCLAAVSRSVSICAAYLM--------YKNQWPVEK
. |.|..|    .|. ..       .| .. ||  . .  |.|   . ....  .   ... | ||| | |.|| ...||.||        . ..... .
tlrtlevtdtgngesrtvth.....fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

ALKMIESVRKTIGPNAGFLAQLKIWE
|.|.. . |  . .. ... .|  ..
avkklReqRpgavqtleqyrflyeal

0050432 (Phosphotyrosine protein) phosphatases II 30-127 2.4e-09 32.4 In-house 182-279 (308) alignment
Range on Protein: 30-127
Range on HMM: 182-279/308.0
IKRVLTLTTEPISEKqkiggVDYKFLHLLDMPDEPILDN-AILETAVLYINEGVeKEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIE
..|.|.||    .|        .. .| .. ||  . .. .|| . . ....   ..... ||| | |.|.  ..|..|.     ... . |..|.|.. 
tvrtleltnlgdges.....rtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklR

SVRK
. | 
eqRp

0049772 (Phosphotyrosine protein) phosphatases II 34-144 1.9e-22 75.8 In-house 167-271 (314) alignment
Range on Protein: 34-144
Range on HMM: 167-271/314.0
LtlttEPIS--EKQKIGGVDYKFLHLLDmPDEPilDNAILETAVLYINEGvEKEENVGVHCLAAVSRSVS-ICAAYLMYKNQWPVEKALKMIESVRKtIG
     | .   |. .  |. |. ... | ...|  . .... .. .|.|  .|...| ||| | ..|. . ..|||||.......|.||... . |  |.
k....eelydpelferlgikylripvpD.gsap..lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.in

PNAGFLAQLKIWER
|| ||. ||. .| 
pnpgfieqleqyef

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 45-144 1.2e-14 48.1 In-house 51-145 (148) alignment
Range on Protein: 45-144
Range on HMM: 51-145/148.0
QkigGVDYKFLHLLDMPDEPIldNAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
.   |..|  . | | |.| .  .|| |... .... ... . | ||.   ||||  .  ..|.  ..  ...|| ...| |. . || ||| ||  .|.
r...gieYlhvaldDkpkedl..saiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq





subfamily_Laforin_pd Subfamily Laforin 45-127 1e-08 28.3 In-house 72-152 (183) alignment
Range on Protein: 45-127
Range on HMM: 72-152/183.0
QKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRK
 |  |. | .| . |.  |  ..|  |  ||  .   .||   | ||| | | || .|   .|.|  .| . |   .. . | 
ykeeglayiwlptedlstesrven..lpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 50-144 1.2e-16 54.5 In-house 56-150 (154) alignment
Range on Protein: 50-144
Range on HMM: 56-150/154.0
VDYKFLHLLDMPDEPILDNaiLETAVLYINEGV--EKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..|  |.| | ..  |...  |. |  .|.. .   ....| ||. . |||| ..  .||| | . .. .||... . |  | || ||| ||.|.|.
ieylnlelfddvnfdiiek..ldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek

0051299 (Phosphotyrosine protein) phosphatases II 50-129 1.2e-08 30.3 In-house 182-268 (288) alignment
Range on Protein: 50-129
Range on HMM: 182-268/288.0
VDYKFLHLLDMPDEPILD--NAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTI
  .. .| .. ||  . |  ...|.   | ..    ..  | ||| | |.|.  ..|..|.     ... . |..|.|.. . |  .
rtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm

subfamily_STYXL1_pd Subfamily STYXL1 56-145 1.7e-15 50.5 In-house 65-152 (157) alignment
Range on Protein: 56-145
Range on HMM: 65-152/157.0
HLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
.. | ..  .|..  |. || .|.. ....| | |     .|||... .|||||....  .||.| ..  .. . || .|. ||. ||..
avedeneadller..lkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq

subfamily_STYX_pd Subfamily STYX 57-144 4.9e-10 32.7 In-house 67-155 (166) alignment
Range on Protein: 57-144
Range on HMM: 67-155/166.0
LLDMPDEPIlDNAI--LETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
.||. |... .| |  | |   .|.. ..|  .| ||  | .||| ..  ||.|        .| ....  |  | ||.||  ||| .| 
vldvadntv.eniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

subfamily_DSP3_pd Subfamily DSP3 59-141 9.3e-16 51.9 In-house 69-152 (162) alignment
Range on Protein: 59-141
Range on HMM: 69-152/162.0
DMPDEPILD-NAILETAVLYINEGVEK-EENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRkTIGPNAGFLAQLKI
.. | |  | ..  |||. .|.| ... |  | ||| . ||||  .  |||| ...  . .|.. ... | .|.|| |||.||. 
evdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLae

subfamily_LRR-DSP_pd Subfamily LRR-DSP 70-144 2.3e-15 50.4 In-house 183-256 (263) alignment
Range on Protein: 70-144
Range on HMM: 183-256/263.0
ILETAVLYINEGVEKeENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
 .|    .|.|| .|   | ||| | |||| ..  .||| |..   ..|| .. . |  | || ||. ||| .|.
hfeetnafieeGrkk.GGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 76-139 3.2e-10 33.3 In-house 71-134 (145) alignment
Range on Protein: 76-139
Range on HMM: 71-134/145.0
LYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQL
 .|. | |.   | |||.| |||||..  |.||   .  . .| . ..| |    ||  || .|
dfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknl

subfamily_MSG5_pd Subfamily MSG5 78-144 3.2e-10 33.4 In-house 92-158 (165) alignment
Range on Protein: 78-144
Range on HMM: 92-158/165.0
INEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
|     |.. . |||   .||| |.  ||.|   .  ...| ... || . | |. |.. ||  || 
ihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewev

subfamily_PTPDC1_pd Subfamily PTPDC1 82-126 3.5e-07 24.8 In-house 111-155 (182) alignment
Range on Protein: 82-126
Range on HMM: 111-155/182.0
VEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVR
. .|..|.||| |   |   . |.||.|...   |||.|.. | |
alqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskr

subfamily_RNGTT_pd Subfamily RNGTT 83-127 6.9e-06 19.9 In-house 111-155 (189) alignment
Range on Protein: 83-127
Range on HMM: 111-155/189.0
EKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRK
. || .||||     |.  . ..||. |..| ||.|...  . |.
npeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp

0048567 (Phosphotyrosine protein) phosphatases II 84-136 2.4e-07 25.3 In-house 73-130 (157) alignment
Range on Protein: 84-136
Range on HMM: 73-130/157.0
KEENVGVHCLAAV---SRSVSICAAYLMYKNQWPVEKALKMIESVR--KTIGPNAGFL
..  . ||| |     .|.. ....||....... |.|....  ||    ... |..|
agkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyl