Gene C24F3.2 in Caenorhabditis elegans

Synonym: CELE_C24F3.2, C24F3.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP023_AA protein Get Run
CeleP023_AA_0-147 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 1-153 2.5e-53 174.7 In-house 2-150 (155) alignment 
Range on Protein: 1-153
Range on HMM: 2-150/155.0
MWKITENLYLAQLPMIVGPTSKQEFsknDIKRVLTLTTEPI-SEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRS
...|...|||..|.... .....|.   .|..||....|.. ..|.|.| |..||...||.|.|.||..  |..|| .|.|..|.|..| ||| |.||||
vsrilpglylggleavqeeellkel...kithvlsvikeelpehklkkgkvstkfiqilDepeediLsh..ldeavdFieealeeegavlvHCqagvSRS

VSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERSGMSFSADQ
|.|..||||.|.....|||||........| ||.|||.|||..|..|..   ..
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsn
subfamily_DSP15_pd Subfamily DSP15 1-146 8.1e-25 81.7 In-house 2-139 (151) alignment 
Range on Protein: 1-146
Range on HMM: 2-139/151.0
MWKITENLYLAQlpmIVGPTSKQEFSKNDIKRVLTLTTepiSEKQKIGGVDYKFLHLLDMPDEPIldNAILETAVLYINEGVEKEENVGVHCLAAVSRSV
. |. ..|||..   .     ..  ....|  .|..     ..|. .  ..||.... | |.  .  . ... .| .| .   ||||| ||||| |||||
iskvlpglylgn...frdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsakl..skffkesvefihkcRlkeenvlvhClaGvsRsv

SICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERSG
 ...||||   .   ..||..|.  | .  ||.||  ||| .|.. 
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
0046846 (Phosphotyrosine protein) phosphatases II 1-144 8.5e-22 73.2 In-house 12-170 (176) alignment 
Range on Protein: 1-144
Range on HMM: 12-170/176.0
MWKITENLYLAQLPMIV-------GPTSKQEFSKNDIKRVLTLTTE------------PISEKQKIggvdykFLHLLDMPDEPILDNAILETAVLYINEG
.. |..||.|  .| .         ..  ... ...|. |..||.|            |. || .|        . |..||  . | ..|.... .|.| 
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......qylhlpwpDhgvpdlelllellefirea

VEKEENVGVHCLAAVSRSVSICAAYLMYK-NQWPVEKALKMIESVRK-TIGPNAGFLAQLKIWER
... ..| ||| | ..|.  ..||||... ....||.||... ..|   . .. ... .|. .|.
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0044763 (Phosphotyrosine protein) phosphatases II 2-147 5e-28 93.3 In-house 24-171 (178) alignment 
Range on Protein: 2-147
Range on HMM: 24-171/178.0
WKITENLYLAQLPMivgPTSKQEFSKNDIKRVLTLTTEPISEKQK-------IGGVDYKFLHLLDMPDEPilDNAILETAVLYINEGV-EKEENVGVHCL
..|...|||..||.   .  .. . ...|. ...||.|    ..|         |. |..... |... .    .... .| .|.| . ||...| ||| 
seilpglylgslpp...addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd..llehflefvefieealdekggpvlVHCs

AAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKtIGPNAGFLAQLKIWERSGM
| |.|| ...|||||.|.....|.|.... ..|  | || |.| ||. .|.  .
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0048179 (Phosphotyrosine protein) phosphatases II 2-144 4.2e-26 86.8 In-house 5-142 (144) alignment 
Range on Protein: 2-144
Range on HMM: 5-142/144.0
WKITENLYLAQLPMIVGptsKQEFSKNDIKRVLTLTTEPISEKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVS
..|...|||  ||. .     ... |..|. |..||.|   |  .  |. | .| . |..  ..|  ..|.... .|.| .|....| ||| | |.|. .
seilpglylgslptald...lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdll..ellleflefieealeeggpvlVHCsaGvgRtgt

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..|||||.|.....|.||... | |  . || |.| .|. .|.
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 2-144 1.8e-24 81.4 In-house 5-140 (145) alignment 
Range on Protein: 2-144
Range on HMM: 5-140/145.0
WKITENLYLAQLPMIVGptsKQEFSKNDIKRVLTLTTEPisEKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVS
..|...|||  ||. .     ... ...|..||.||.|.  |  .  |. | .| . |..  ..|  ..|.... .|.| ......| ||| | |.|. .
seilpglylgslptald...lellkdlgittvlnltsel..ellerlgiqylylpwpDhgvpdll..ellleflefieealkeggpvlVHCsaGvgRtgt

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..|||||.......|.||... | |  . || |.| .|. .|.
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_DSP14_pd Subfamily DSP14 2-145 2.5e-22 73.5 In-house 8-143 (157) alignment 
Range on Protein: 2-145
Range on HMM: 8-143/157.0
WKITENLYLAqlpmIVGPTSKQEFSKNDIKRVLTLTTEPISekQKIGGVDYKFLHLLDMPDEPILDnaILETAVLYINEGVEKEENVGVHCLAAVSRSVS
 .||..|.|.     |. .||....|. |  .. .|.|  .  .|. ....  . . |.|.. . .   ..... .|.|  .|. .. ||| | |||| |
sqitpsLfls....gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklak..hfdevadkieevkkkggktlvhCvaGvSRSAs

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
.| ||||  ..   ..| |...|.|  | || ||  ||  .|. 
lclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
0041856 (Phosphotyrosine protein) phosphatases II 2-145 4e-22 74.1 In-house 20-171 (182) alignment 
Range on Protein: 2-145
Range on HMM: 20-171/182.0
WKITENLYLAQLPMIV-----------GPTSKQEFSKNDIKRVLTLTtEPIS--EKQKIGGVDYKFLHLLDMPDEPildnaiLETAVLYINEGVEKEENV
..|..||||  ||               .   . . ...|. ...|| |.    |. .  |. |..|   |..  .      |.... .|.|  |....|
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd......ldelldfieevleeggpv

GVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRK--TIGPNAGFLAQLKIWERS
 ||| | |.|. ...|||||.|.....|.|.|.. | |    | || .|. ||...|. 
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0036282 (Phosphotyrosine protein) phosphatases II 2-143 1.5e-19 65.8 In-house 13-166 (174) alignment 
Range on Protein: 2-143
Range on HMM: 13-166/174.0
WKITENLYLAQLPMIvgptSKQEFSKNDIKRVLTLTTEPISEKQKI----------GGVDYKFLHLLDMPDEPILDNAILETAVLYINEGVEK--EENVG
. ||..|.. | |.       ... ...|. |..|..|   .. |.                 .. | .||    | .||...| ...| ...  .  | 
syitprliagqgpla....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCLAAVSRSVSICAAYLMYKNQW-PVEKALKMIESVR---KTIGPNAGFLAQLKIWE
||| | |.|.  ..|||||..... ....||... ..|     . .. ... .|  .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0037934 (Phosphotyrosine protein) phosphatases II 2-143 1.4e-18 62.8 In-house 40-238 (243) alignment 
Range on Protein: 2-143
Range on HMM: 40-238/243.0
WKITENLYLAQLPMIV-----GPTSKQEFSKNDIKRVLTLTTEP------------------------------------------IS-EKQKIGGVDYK
 ..|..|.. |.|.         .  . . ...|. ...||..                                           .. ....  .. | 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

FLHLLD--MPDEPILDNAILETAVLYINE-----GVEKEENVGVHCLAAVSRSVSICAAYLMYKN-QWPVEKALKMIESVRKT-IGPNAGFLAQLKIWE
.|   |  .||.|    ..|. .  .|.|        ... | ||| | |.|.  ..|||||... ....|.|.|.. . |   . .. ... .|  ..
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0051082 (Phosphotyrosine protein) phosphatases II 2-141 1.9e-17 58.7 In-house 9-148 (151) alignment 
Range on Protein: 2-141
Range on HMM: 9-148/151.0
WKITENLYLAQLPmivGPTSKQEFSKNDIKRVLTLTTEP----ISEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEK-EENVGVHCLAAV
. .|..||. . |    .   ... ...|| ...|..|.      |  .  |.... ...||.|| .. ..  ..... ....  .| . .| ||| | .
syvtgglyrsggp...ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglpls..fdavleflellldkkngpvlvHCsaGk

SRSVSICAAYLMYkNQWPVEKALKMIESVRK-TIGPNAGFLAQLKI
.|.  ..|.|||.  ....|.||... . |   . || .|| ||. 
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_DSP19_pd Subfamily DSP19 3-144 1e-25 84.8 In-house 14-148 (152) alignment 
Range on Protein: 3-144
Range on HMM: 14-148/152.0
KITENLYLAQLPmivGPTSKQEFSKNDIKRVLTLTTEPISEkqKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSI
.....|||.      . ..|.......|  .| ..|.          . |. ...|| |.. .|.   |..|. .|.|. .|.  | ||| | ||||.|.
eveprlylgsqd...vaadkeilkekkitHilnvatgvpnv..fpkdftylsieilDlpetdllsy..lkealdFieearskdgavlvHCnAGvSRsasv

CAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
  |||| |..  .|.||... ..|..| ||.||. ||| .| 
viaylmkkeelsleealelvrearpcikPneGFikqLkeyea
PTPc_motif_SM00404 3-144 2.4e-24 80.8 In-house 4-139 (140) alignment 
Range on Protein: 3-144
Range on HMM: 4-139/140.0
KITENLYLAQLPMIVgptSKQEFSKNDIKRVLTLTTE-PISekQKIGGVDYKFLHLLDMPDEPILDnaILETAVLYINEGVEKEENVGVHCLAAVSRSVS
.|...|||.... ..   ...  .|..|. |. .|.| ...  ..  |. .. . | |   .....   |. .. .|..  .|...| ||| | ||||..
rilphlylgskskaq...npallkklgithvinvteevslt..kensgfqilqiplddnekdklsk..yldkvldfienaekkggkvlVHCqaGvSRSat

ICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
...||||...|. ...|...... |..| ||..|..||  .|.
liiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP8_pd Subfamily DSP8 3-145 6.2e-17 55.6 In-house 17-153 (159) alignment 
Range on Protein: 3-145
Range on HMM: 17-153/159.0
KITENLYLAQLpmiVGPTSKQEFSKNDIKRVLTLTTEPIsEKQKIGGVDYKFLHLLDMPDEPILDnaILETAVLYINEGVEKEENVGVHCLAAVSRSVSI
.|..||||      . . |.. .||..|  || . .. . .....  . .  . . |  || .|.  .....| .|.  .... .| ||.||  ||| ..
rilknlylGsq...kdvlseellsklgisyvlnasnscp.kleelkeskflrvPvkDkydekllp..wfdksvefidkaksengrvlvhvlaGisrsatv

CAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
  ||.| . .  ...| . . . |.|| ||  || ||  .|..
aiayimktlemsldeayrfvkekrptispnlnflgqLleyeke
0042113 (Phosphotyrosine protein) phosphatases II 3-143 1.7e-16 55.8 In-house 49-239 (245) alignment 
Range on Protein: 3-143
Range on HMM: 49-239/245.0
KITENLYLAQLPMIVgptSKQ----EFSKNDIKRVLTLTTEPISEK-----------------------------------------QKIGGVDYKFLHL
.||......| |.     . .     . ...|. ...||.|   ..                                         ..        .| 
ritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

LDMPDEPILD-NAILETAVLYINEGVE--KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWE
|..|| .. |  ..|. .. .... ..  ... | ||| | |.|.  ..|||||     .   ...|.|.|.. | |  . .. ... .|  ..
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_PTPMT1_pd Subfamily PTPMT1 3-137 7.3e-16 53.1 In-house 22-159 (171) alignment 
Range on Protein: 3-137
Range on HMM: 22-159/171.0
KITENLYLAQLPmiVGPTSKQEFSKNDIKRVLTLTTE-------PISEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAA
.| ....| .||  .  . |. ..|...|.|..|. |         .|. |  ||..  |   |. ..| |..  || .| .|..  .| . | ||| | 
riDdtvilGalP..frslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdlek..lekgvefiekvaskgkrvYvHCkaG

VSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLA
 .|| .. |.|||.|...  |.|||.... ||.|  .   . 
rgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwk
subfamily_DSP6_pd Subfamily DSP6 4-145 1.7e-22 73.6 In-house 17-153 (158) alignment 
Range on Protein: 4-145
Range on HMM: 17-153/158.0
ITENLYLAQLPMivgPTSKQEFSKNDIKRVLTLTTEPISEKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSIC
|...||| .       .  . ..| .||.|| .|..  .  .. | . |. . . |   . .   . .  |. .|.|. .|...| ||||| .|||| ..
ilpllylGsakd...asnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnla..kffPeaiefidearskkskvlvhClaGisrsvtvt

AAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
 |||| |..  ...| ..... .  | ||  |. ||. .|||
laylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_DSP1_pd Subfamily DSP1 4-145 6.5e-22 72.3 In-house 21-155 (163) alignment 
Range on Protein: 4-145
Range on HMM: 21-155/163.0
ITENLYLAQLpmiVGPTSKQEFSKNDIKRVLTLTTEpISEKQKIgGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSIC
|.. |||         . ..  ....|  .| ...| ...  .     || |.| | |.. |   ...|... .|.|  .|.  | .|| | .||| ..|
ildfLylGse...tvasnleiLkslgitailnvske.ldnvfed.lfeYkklkleDspkadis..lvfeeviefidevkkknGkvlihCqaGisRsstlc

AAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
 |||| .... .|.| ... ..|. | |||||  ||. .|..
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
0051429 (Phosphotyrosine protein) phosphatases II 6-144 2.4e-16 55.7 In-house 21-222 (272) alignment 
Range on Protein: 6-144
Range on HMM: 21-222/272.0
EN-LYLAQLPMIVGPTSKQEFSKNDIKRVLTLTTEPISEKQK----IGGVDYKFLHLLDMPDEPILDNA-------------------------------
.. ||... |. . . . . . ...|| ...|..|   ...|    . |..| .|..||. ...|| .|                               
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

--------------ILETAVLYIN----EgvekEENVGVHCLAAVSRSVSICAAYLMYkNQWP--------------VEKALKMIESVRKTIGPNAGFLA
              . . |.| .     .    ...| ||| | ..|.  ..|..|..  ...              .|.|.... ..|  .... ....
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLKIWER
.|  ...
flyeall
subfamily_DSP23_pd Subfamily DSP23 10-124 4.5e-08 27.9 In-house 12-123 (148) alignment 
Range on Protein: 10-124
Range on HMM: 12-123/148.0
LAQLPMIVGPTSKQEFSKNDIKRVLTLTTEPISEKQKIGGVDYKFLHLLDMpDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMY
|| | .   |   . .  . .. ...||.|   . . . .. .. | . |.   | |..  ..  |  ..|  ||.| |.||||    |. .. | ||. 
laalalprlpdqyrylldlgvrylvslteegrphveatpnltlvrlriddy.hppaleq..vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvk

KNQWPVEKALKMIES
...    .|.  .  
erklaaaeaiaevrr
subfamily_DSP10_pd Subfamily DSP10 21-144 3.2e-21 69.8 In-house 31-151 (159) alignment 
Range on Protein: 21-144
Range on HMM: 31-151/159.0
SKQEFSKNDIKRVLTLTTEPISEKQKiGGVDYKFLHLLDMPDEPIldNAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALK
... . . .|. || .||.   | ..  .. || . . |   . .  .   | |. .|.|  .|...| ||| | .|||...  ||||.. .  ...| |
dldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnl..kqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndayk

MIESVRKTIGPNAGFLAQLKIWER
.... | .| || .|. ||. .|.
fvkekrpiisPnLnfmGqLlefek
DSPc Dual specificity phosphatase, catalytic domain 22-144 4.8e-23 76.5 Pfam-A 11-132 (133) alignment 
Range on Protein: 22-144
Range on HMM: 11-132/133.0
KQEFSKNDIKRVLTLTTEPIS-EKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALK
..  .|..|. |. .|.|     ..| .  .|  . . |. .. |   . || || .|..  .|...| ||| | .||| ....||||.........|..
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkis..keleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

MIESVRKTIGPNAGFLAQLKIWER
.... |..| ||||||.||  .||
fvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 22-144 4.8e-23 76.5 In-house 11-132 (133) alignment 
Range on Protein: 22-144
Range on HMM: 11-132/133.0
KQEFSKNDIKRVLTLTTEPIS-EKQKIGGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALK
..  .|..|. |. .|.|     ..| .  .|  . . |. .. |   . || || .|..  .|...| ||| | .||| ....||||.........|..
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkis..keleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

MIESVRKTIGPNAGFLAQLKIWER
.... |..| ||||||.||  .||
fvkerrskispnagflrqLleyer
0043147 (Phosphotyrosine protein) phosphatases II 22-145 2.2e-20 68.5 In-house 37-159 (172) alignment 
Range on Protein: 22-145
Range on HMM: 37-159/172.0
KQEFSKNDIKRVLTLTTE-PISEKQKIGGVDYKFLHLLDMPDEpilDNAILETAVLYINE--GVEKEENVGVHCLAAVSRSVSICAAYLMYkNQWPVEKA
 . . ...|. ...||..  . |. .  |. | .|   |..     . ..|. .. .|.|   ..... | ||| | |.|.. ..|||||.  ....|.|
wrmlkelgithivnltellydpellerlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleea

LKMIESVRKTIGPNAGFLAQLKIWERS
.... . |  . .| ... .|. .|. 
valvrekRpgavqnpsqyrflyyfekl
0049260 (Phosphotyrosine protein) phosphatases II 22-143 1e-18 63.0 In-house 26-146 (152) alignment 
Range on Protein: 22-143
Range on HMM: 26-146/152.0
KQEFSKNDIKRVLTLTTEPIseKQKIGGVDYKFLHLLDMPDEPILDNAILETAVLYINE--GVEKEENVGVHCLAAVSRSVSICAAYLMYkNQWPVEKAL
.. . ...|. ...||..    . |..   |   . | .|| .  |...|   .| . |    .|...| ||| | |.|.  ..|||||. .....|.|.
wrmlkelgittivmltelle..lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeav

KMIESVRKTIGPNAGFLAQLKIWE
... . |. . || |.| .|. .|
alvrekRpgavpnpgqlrflyefe
subfamily_Slingshot_pd Subfamily Slingshot 22-143 3.9e-18 59.4 In-house 37-154 (169) alignment 
Range on Protein: 22-143
Range on HMM: 37-154/169.0
KQEFSKNDIKRVLTLTTEpIsEKQKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKM
 .|...|... .| .| | | ..   . ..|. ... | ... .|..   ...  .|..  .|. .| |||   |||| |.  || | . .. .|.||. 
leelkengveyilnvtke.i.dnffpekfeylnirvydeeetdllky..wnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealey

IESVRKTIGPNAGFLAQLKIWE
... |. | ||.||| ||...|
vkerrsvikPnkgflkqleeye
0045098 (Phosphotyrosine protein) phosphatases II 22-145 2e-17 59.0 In-house 81-270 (278) alignment 
Range on Protein: 22-145
Range on HMM: 81-270/278.0
KQEFSKNDIKRVLTLTTE---------------------------------------------PISEKQKIGGVDYKFLHLLDMPDEPILDNA---ILET
 . . ...|. ...||..                                               .|.. .     . ||.| .||  . ..     .  
wrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfle

AVLYINEGVE--------------KEENVGVHCLAAVSRSVSICAAYLMYKN---QWPVEKALKMIESVRKT-IGPNAGFLAQLKIWERS
.. .|.| ..              ... | ||| | |.|.  ..|||||...   .. ...|.|.. | |   . .| ... .|  ... 
llefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_MKPLT_pd Subfamily MKPLT 22-144 5.1e-15 49.4 In-house 40-158 (164) alignment 
Range on Protein: 22-144
Range on HMM: 40-158/164.0
KQEFSKNDIKRVLTLTTEPISEKQKigGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKM
..   . .|. .. ...|  .   |   |.|  ... | .|| .   . || |  .. . ..    | |||   .||| |.  |.|.  ..| ...| . 
ekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqls..sfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayey

IESVRKTIGPNAGFLAQLKIWER
.   |  . || ||| ||  .|.
lkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 22-144 5.1e-15 49.4 In-house 40-158 (164) alignment 
Range on Protein: 22-144
Range on HMM: 40-158/164.0
KQEFSKNDIKRVLTLTTEPISEKQKigGVDYKFLHLLDMPDEPILdnAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKM
..   . .|. .. ...|  .   |   |.|  ... | .|| .   . || |  .. . ..    | |||   .||| |.  |.|.  ..| ...| . 
ekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqls..sfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayey

IESVRKTIGPNAGFLAQLKIWER
.   |  . || ||| ||  .|.
lkerrsivapnrGflkqlakfee
0040439 (Phosphotyrosine protein) phosphatases II 23-143 1.6e-16 56.2 In-house 72-242 (249) alignment 
Range on Protein: 23-143
Range on HMM: 72-242/249.0
QEFSKNDIKRVLTLTTEPISEK-----------------------------------------QKIGGVDYKFLHLLDMPDEPIL-DNAILETAVLYINE
. . ...|. ...||..   ..                                         ..   . .. .. .|.||  .  . ..|   . ....
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

GVE---KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWE
 .|   |.. | ||| | |.|.  ..|||||     .......| |.|.. | |  . .| ... .|  ..
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 23-143 2.1e-15 52.7 In-house 125-300 (307) alignment 
Range on Protein: 23-143
Range on HMM: 125-300/307.0
QEFSKNDIKRVLTLTTEP---------------------------ISEKQkIGGVDYKFLHLLDM-----------------PDEPILDN-AILETAVLY
. . ..... ...||..                            .||..  .|. .  |.. |.                 ||  . .. ..|   . .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

INEGVE---KEENVGVHCLAAVSRSVSICAAYLMYKNQ--------WPVEKALKMIESVRKTIGPNAGFLAQLKIWE
... .|   |.. | ||| | |.|. ...|||||...         .....|.|.. . |  . .| ... .|  ..
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 23-144 1.2e-14 50.0 In-house 119-286 (297) alignment 
Range on Protein: 23-144
Range on HMM: 119-286/297.0
QEFSKNDIKRVLTLTTEP------------------------ISEKQkigGVD----------------YKFLHLLDMPDEPIL-DNAILETAVLYINEG
. . ..... ...||..                         .....     .                .. .. ...||  .  . ..|  .. ...| 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrea

VE---KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..   |.. | ||| | |.|. ...|||||     .. .. |..|.|.. . |  . .. ... .|  ...
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0040438 (Phosphotyrosine protein) phosphatases II 23-145 1.6e-14 49.3 In-house 104-274 (317) alignment 
Range on Protein: 23-145
Range on HMM: 104-274/317.0
QEFSKNDIKRVLTLTTEP--------------------------ISEKQkIGGVDYKFLHLLDM----------------PDEPIL-DNAILETAVLYIN
. . ..... ...||..                           .||..  .|. .  |.. |.                ||  .  .  .|   . ...
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EGVEK-EENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
|  |. .. | ||| | |.|. ...|||||     ..... ||.|.|.. . |  . .. ... .|  ... 
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
PTEN_1 24-140 1.4e-18 62.4 In-house 62-185 (196) alignment 
Range on Protein: 24-140
Range on HMM: 62-185/196.0
EFSKNDIKRVLTLTTEPIS-----EKQKIGGVDYKFLHlLDMPDEPILDNAILETAVLYINEGVEK---EENVGVHCLAAVSRSVSICAAYLMYKNQWPV
.. ...|  |..|. |.       ....    ....|| ....| .  . . |  ..  . | . .   ...| ||| | ..||. ..|||||||... .
nlkedgitlvvnlseeeelsgrsydleeffksgveylh.fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgklta

EKALKMIESVRKTIGPNAGFLAQLK
..||... . |  ..|| ... .|.
deAlelvrekRppgapnspsqerll
0046845 (Phosphotyrosine protein) phosphatases II 25-127 5.4e-10 34.6 In-house 144-254 (284) alignment 
Range on Protein: 25-127
Range on HMM: 144-254/284.0
FSKNDIKRVLTLTTEPISEKQkiggVDYKFLHLLDMPDEPIL-DNAILETAVLYINEGVEK---EENVGVHCLAAVSRSVSICAAYLMYKN--------Q
  .. ..|.|.|| . ....     .  . .| .. ||  .  . ..| . . ...|  |.   .. . ||| | |.|.  ..|..|...          
vkddytvrtleltnlgytges....rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllg

WPVEKALKMIESVRK
..|..|.|.. . | 
vdvleavkrlreqRp
0043336 (Phosphotyrosine protein) phosphatases II 27-142 1.2e-11 40.1 In-house 110-272 (278) alignment 
Range on Protein: 27-142
Range on HMM: 110-272/278.0
KNDIK---------------------------------------------RVLTLTTEPISEKqkiggVDYKFLHLLDMPDEPIL-DNAILETAVLYINE
.....                                             |.|..|    .|.          .| |..||  .  . ..|   . ...|
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges.....rtvthyhylgwpdhgvpeslsllldflkavre

GVE-KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIW
 .| ... | ||| | |.|.  ..|.||.     .   ...|.|.|.. . |  . ..  .. .|  .
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0038934 (Phosphotyrosine protein) phosphatases II 29-142 2e-15 52.4 In-house 56-172 (194) alignment 
Range on Protein: 29-142
Range on HMM: 56-172/194.0
DIKRVLTLT-TEPISEKQKIGGVDYKFLHLLDMPDEPILDNAILETAVLYINEGVEK--EENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESV
..  |..|| ||.  ..... ......|.|  . | .. ...|| . .  ..| ...  .. |.||| | ..|.  ..||||.|......|.|.......
klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrek

RKTIGPNAGFLAQLKIW
|. . || ..| .|  .
Rpgaipnqdyleallkr
0047943 (Phosphotyrosine protein) phosphatases II 29-139 4.2e-11 38.3 In-house 150-264 (273) alignment 
Range on Protein: 29-139
Range on HMM: 150-264/273.0
DIKRVLTLTTEPISEKqkiggVDYKFLHLLDMPDEPIL-DNAILETAVLYINEGVE---KEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKAL
 ..|.|.||    .|.       .. .| .. ||  .  . ..| . . ....  |   ... | ||| | |.|. ...|..|.     ..... |..|.
ytvrtleltnlgtges.....rtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleav

KMIESVRKTIGPNAGFLAQL
|.. | |  . ..  .. .|
kllrsqRpgmvqtpeqyrfl
0036941 (Phosphotyrosine protein) phosphatases II 30-143 1.9e-11 39.3 In-house 153-273 (297) alignment 
Range on Protein: 30-143
Range on HMM: 153-273/297.0
IKRVLTLTTEPISEKQKIGGvdykfLHLLDMPDEPILD-NAILETAVLYINEGVE---KEENVGVHCLAAVSRSVSICAAYLM--------YKNQWPVEK
. |.|..|    .|. ..       .| .. ||  . .  |.|   . ....  .   ... | ||| | |.|| ...||.||        . ..... .
tlrtlevtdtgngesrtvth.....fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

ALKMIESVRKTIGPNAGFLAQLKIWE
|.|.. . |  . .. ... .|  ..
avkklReqRpgavqtleqyrflyeal
0050432 (Phosphotyrosine protein) phosphatases II 30-127 2.4e-09 32.4 In-house 182-279 (308) alignment 
Range on Protein: 30-127
Range on HMM: 182-279/308.0
IKRVLTLTTEPISEKqkiggVDYKFLHLLDMPDEPILDN-AILETAVLYINEGVeKEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIE
..|.|.||    .|        .. .| .. ||  . .. .|| . . ....   ..... ||| | |.|.  ..|..|.     ... . |..|.|.. 
tvrtleltnlgdges.....rtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklR

SVRK
. | 
eqRp
0049772 (Phosphotyrosine protein) phosphatases II 34-144 1.9e-22 75.8 In-house 167-271 (314) alignment 
Range on Protein: 34-144
Range on HMM: 167-271/314.0
LtlttEPIS--EKQKIGGVDYKFLHLLDmPDEPilDNAILETAVLYINEGvEKEENVGVHCLAAVSRSVS-ICAAYLMYKNQWPVEKALKMIESVRKtIG
     | .   |. .  |. |. ... | ...|  . .... .. .|.|  .|...| ||| | ..|. . ..|||||.......|.||... . |  |.
k....eelydpelferlgikylripvpD.gsap..lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.in

PNAGFLAQLKIWER
|| ||. ||. .| 
pnpgfieqleqyef
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 45-144 1.2e-14 48.1 In-house 51-145 (148) alignment 
Range on Protein: 45-144
Range on HMM: 51-145/148.0
QkigGVDYKFLHLLDMPDEPIldNAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
.   |..|  . | | |.| .  .|| |... .... ... . | ||.   ||||  .  ..|.  ..  ...|| ...| |. . || ||| ||  .|.
r...gieYlhvaldDkpkedl..saiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Laforin_pd Subfamily Laforin 45-127 1e-08 28.3 In-house 72-152 (183) alignment 
Range on Protein: 45-127
Range on HMM: 72-152/183.0
QKIGGVDYKFLHLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRK
 |  |. | .| . |.  |  ..|  |  ||  .   .||   | ||| | | || .|   .|.|  .| . |   .. . | 
ykeeglayiwlptedlstesrven..lpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 50-144 1.2e-16 54.5 In-house 56-150 (154) alignment 
Range on Protein: 50-144
Range on HMM: 56-150/154.0
VDYKFLHLLDMPDEPILDNaiLETAVLYINEGV--EKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
..|  |.| | ..  |...  |. |  .|.. .   ....| ||. . |||| ..  .||| | . .. .||... . |  | || ||| ||.|.|.
ieylnlelfddvnfdiiek..ldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek
0051299 (Phosphotyrosine protein) phosphatases II 50-129 1.2e-08 30.3 In-house 182-268 (288) alignment 
Range on Protein: 50-129
Range on HMM: 182-268/288.0
VDYKFLHLLDMPDEPILD--NAILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLM-----YKNQWPVEKALKMIESVRKTI
  .. .| .. ||  . |  ...|.   | ..    ..  | ||| | |.|.  ..|..|.     ... . |..|.|.. . |  .
rtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm
subfamily_STYXL1_pd Subfamily STYXL1 56-145 1.7e-15 50.5 In-house 65-152 (157) alignment 
Range on Protein: 56-145
Range on HMM: 65-152/157.0
HLLDMPDEPILDNaiLETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWERS
.. | ..  .|..  |. || .|.. ....| | |     .|||... .|||||....  .||.| ..  .. . || .|. ||. ||..
avedeneadller..lkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_STYX_pd Subfamily STYX 57-144 4.9e-10 32.7 In-house 67-155 (166) alignment 
Range on Protein: 57-144
Range on HMM: 67-155/166.0
LLDMPDEPIlDNAI--LETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
.||. |... .| |  | |   .|.. ..|  .| ||  | .||| ..  ||.|        .| ....  |  | ||.||  ||| .| 
vldvadntv.eniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP3_pd Subfamily DSP3 59-141 9.3e-16 51.9 In-house 69-152 (162) alignment 
Range on Protein: 59-141
Range on HMM: 69-152/162.0
DMPDEPILD-NAILETAVLYINEGVEK-EENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRkTIGPNAGFLAQLKI
.. | |  | ..  |||. .|.| ... |  | ||| . ||||  .  |||| ...  . .|.. ... | .|.|| |||.||. 
evdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLae
subfamily_LRR-DSP_pd Subfamily LRR-DSP 70-144 2.3e-15 50.4 In-house 183-256 (263) alignment 
Range on Protein: 70-144
Range on HMM: 183-256/263.0
ILETAVLYINEGVEKeENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
 .|    .|.|| .|   | ||| | |||| ..  .||| |..   ..|| .. . |  | || ||. ||| .|.
hfeetnafieeGrkk.GGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 76-139 3.2e-10 33.3 In-house 71-134 (145) alignment 
Range on Protein: 76-139
Range on HMM: 71-134/145.0
LYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQL
 .|. | |.   | |||.| |||||..  |.||   .  . .| . ..| |    ||  || .|
dfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknl
subfamily_MSG5_pd Subfamily MSG5 78-144 3.2e-10 33.4 In-house 92-158 (165) alignment 
Range on Protein: 78-144
Range on HMM: 92-158/165.0
INEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRKTIGPNAGFLAQLKIWER
|     |.. . |||   .||| |.  ||.|   .  ...| ... || . | |. |.. ||  || 
ihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewev
subfamily_PTPDC1_pd Subfamily PTPDC1 82-126 3.5e-07 24.8 In-house 111-155 (182) alignment 
Range on Protein: 82-126
Range on HMM: 111-155/182.0
VEKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVR
. .|..|.||| |   |   . |.||.|...   |||.|.. | |
alqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskr
subfamily_RNGTT_pd Subfamily RNGTT 83-127 6.9e-06 19.9 In-house 111-155 (189) alignment 
Range on Protein: 83-127
Range on HMM: 111-155/189.0
EKEENVGVHCLAAVSRSVSICAAYLMYKNQWPVEKALKMIESVRK
. || .||||     |.  . ..||. |..| ||.|...  . |.
npeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
0048567 (Phosphotyrosine protein) phosphatases II 84-136 2.4e-07 25.3 In-house 73-130 (157) alignment 
Range on Protein: 84-136
Range on HMM: 73-130/157.0
KEENVGVHCLAAV---SRSVSICAAYLMYKNQWPVEKALKMIESVR--KTIGPNAGFL
..  . ||| |     .|.. ....||....... |.|....  ||    ... |..|
agkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyl